Dale O. Cowley, Jaime A. Rivera‐Pérez, Mark J. Schliekelman, Yizhou Joseph He, Trudy G. Oliver, Lucy Lu, Ryan O'Quinn, Edward D. Salmon, Terry Magnuson, Terry Van Dyke,
Aurora-A is a conserved kinase implicated in mitotic regulation and carcinogenesis. Aurora-A was previously implicated in mitotic entry and spindle assembly, although contradictory results prevented a clear understanding of the roles of Aurora-A in mammals. We developed a conditional null mutation in the mouse Aurora-A gene to investigate Aurora-A functions in primary cells ex vivo and in vivo. We show here that conditional Aurora-A ablation in cultured embryonic fibroblasts causes impaired mitotic ...
Tópico(s): Cancer-related Molecular Pathways
2008 - Taylor & Francis | Molecular and Cellular Biology
Mark J. Schliekelman, Dale O. Cowley, Ryan O'Quinn, Trudy G. Oliver, Lucy Lu, Edward D. Salmon, Terry Van Dyke,
Abstract Bub1 is a serine/threonine kinase originally described as a core component of the spindle assembly checkpoint (SAC) mechanism in yeast. Bub1 binding at kinetochores has been reported to be required for SAC function and localization of other SAC components. A proper SAC is believed to be essential for murine embryonic development, as all previously described null mutations in SAC components in mice cause embryonic lethality. We produced mice harboring a Bub1 mutant allele lacking exons 2 ...
Tópico(s): Cellular transport and secretion
2008 - American Association for Cancer Research | Cancer Research
Hannah M. Knochelmann, Joshua D. Horton, Sixue Liu, Kent Armeson, John M. Kaczmar, Megan M. Wyatt, Mary S. Richardson, Shirley H. Lomeli, Ying Xiong, Evan M. Graboyes, Eric J. Lentsch, Joshua D. Hornig, Judith M. Skoner, Seth Stalcup, Maria Vittoria Spampinato, Elizabeth Garrett‐Mayer, Elizabeth C. O’Quinn, Cynthia Timmers, Martin J. Romeo, John Wrangle, Matthew R. Young, Mark P. Rubinstein, Terry A. Day, Roger S. Lo, Chrystal M. Paulos, David M. Neskey,
Oral cavity squamous cell carcinoma (OCSCC) is a prevalent surgically treated subset of head and neck cancer with frequent recurrence and poor survival. Immunotherapy has demonstrated efficacy in recurrent/metastatic head and neck cancer. However, whether antitumor responses could be fostered by neoadjuvant presurgical immunotherapy remains unclear. Using a Simon's two-stage design, we present results of a single-arm phase-II trial where 12 patients with stage II-IVA OCSCC received 3 to 4 biweekly ...
Tópico(s): Salivary Gland Tumors Diagnosis and Treatment
2021 - Elsevier BV | Cell Reports Medicine
Constantine A. Gatsonis, Denise R. Aberle, Christine D. Berg, William C. Black, Timothy R. Church, Richard M. Fagerstrom, Barbara Galen, Ilana F. Gareen, Jonathan Goldin, John K. Gohagan, Bruce J. Hillman, C. Carl Jaffe, Barnett S. Kramer, David A. Lynch, Pamela M. Marcus, Mitchell D. Schnall, Daniel C. Sullivan, Dorothy Sullivan, Carl J. Zylak, Christopher H. Cagnon, Dianna D. Cody, Glenn Fletcher, Michael Flynn, Philip F. Judy, Randell Kruger, Frederick J. Larke, Michael F. McNitt‐Gray, Thomas Payne, J. Anthony Seibert, Xizeng Wu, Gerald F. Abbott, Judith K. Amorosa, R. Graham Barr, Phillip M. Boiselle, Caroline Chiles, Robert A. Clark, Lynn Coppage, Robert Falk, Elliot K. Fishman, David Gemmel, Jonathan Goldin, Eric T. Goodman, Eric Hart, Todd R. Hazelton, Elizabeth Johnson, Ella A. Kazerooni, Barbara L. McComb, Geoffrey McLennan, Reginald F. Munden, James Ravenel, Michael A. Sullivan, Stephen J. Swensen, Drew A. Torigian, Kay H. Vydareny, John A. Worrell, Peter W. Balkin, Mona N. Fouad, Matthew T. Freedman, Kavita Garg, Edward P. Gelmann, David S. Gierada, William G. Hocking, Subbarao Inampudi, Claudine Isaacs, Paul A. Kvale, Howard Mann, William Manor, Hrudaya Nath, Douglas J. Reding, David L. Spizarny, Diane C. Strollo, John Waltz, Mei‐Hsiu Chen, Fenghai Duan, Grant Izmirilian, Paul F. Pinsky, Philip C. Prorok, Anthony B. Miller, Martin J. Edelman, William K. Evans, Robert S. Fontana, Mitchell Machtay, Kenneth W. Clark, Kathy L. Clingan, Melissa Ford, Guillermo Márquez, Steven M. Moore, Peter Ohan, Thomas Payne, Steven Peace, Jennifer L. Rosenbaum, R. Graham Barr, William C. Black, Drew A. Torigian, Kay H. Vydareny, John A. Worrell, Robert C. Young, David S. Alberts, David L. DeMets, Peter Greenwald, Paula Jacobs, Theresa C. McLoud, David P. Naidich, James M. Tatum, Edward A. Sausville, Wylie Burke, Gene Colice, Brenda K. Edwards, Scott Emerson, John Fletcher, Sylvan Green, Russell Harris, Jeffrey S. Klein, Edward L. Korn, Robert Mayer, Joe V. Selby, David W. Sturges, Bruce W. Turnbull, Thomas J. Watson, Stephen Baylin, Neil E. Caporaso, Philip A. Dennis, Steve Dubinett, Wilbur A. Franklin, William E. Grizzle, Fred R. Hirsch, Pierre P. Massion, Kathy McKeeta-Frobeck, John D. Minna, Edward F. Patz, Margaret R. Spitz, Christine B. Berg, Donald K. Corle, Ping Hu, Grant Izmirlian, Jennifer Gaegler, Susan Hoffman, Charles Jackson, Erin O. Lange, Evanthia Papadopoulos, Constantine Gatsonis, Ilana F. Gareen, Charles Apgar, Anna Boyle, Tom Caldwell, Nancy Fredericks, Deborah Harbison, Donna Hartfeil, Sharon Jones, Steve King, Irene Mahon, Rosa Medina, Cindy Masiejczyk, Peter Zamora, Hank Brastater, Vish Iyer, Jincy George, Dinakar Gopalakrishnan, Patricia Blair, Michael Bradley, C. Crozier, M. Oh, Nicole Spiese, Chris Steward, Mary Kelly-Truran, Tess Thompson, Erin Cunningham, Anthony Levering, Kathleen McMurtrie, Michael Nahill, Sharlene Snowden, Kesha Smith, Fraser Wilton, Timothy T. Welsh, Rex Welsh, Wendell Christie, Stephanie Clabo, Roberta Clune, Natalie Cunningham, J. C. Upshaw Downs, Lindsey Dymond, Julianne Falcone, Shani Harris, Pam Harvey, Jane E. Hill, Laura Hill, Donna Letizia, Kendrick Looney, Hugh McGinley, Angelee Mean, Marcella Moore, Ryan J. Norton, Valentina Ortico, Sophia Sabina, R. Cabrera Sole, Jo Ann Stetz, Arnold Ssali, John Stubblefield, Tina Taylor, Shovonna White, Jiahong Lu, Amanda Adams, Sarah E. Baum, Meridith Blevins, Patricia S. Fox, Vincent Girardi, Jeremy Gorelick, EDWARD LIVINGSTON HUNT, Quentin McMullen, Karthikeyan Meganathan, Regina Rendas‐Baum, Jo Rean D Sicks, Bradley S. Snyder, Melanie Yeh, Maryann Duggan, Cheryl Souza, Jack Cahill, Brenda Brewer, Barbara O’Brien, G. Devereux, Melissa S. Fritz, Miriam Galbraith, Judith Harkins, Kristen Keating, Kirk Midkiff, Usha Singh, Thea Palmer Zimmerman, Nancy Payte, Helen Price, Clifford Caughman, Ramachandra Chanapatna, Mike Florzyk, Annabelle Lee, Alan Morgan, Jennifer Yang, L. Ellen Martinusen, June McSwain, Rhonda Rosario, Jagdish Singh, R. Adam DeBaugh, Sharan Campleman, Mary Mesnard, Lawrence R. Ragard, Terry Lewis, Lois Roberts, Vijayasri Narayanaswami, Vanessa Ralda, William C. Lake, Thomas Riley, Jonathan B. Clapp, Joe Austin, Brian K. Irons, Fang F. Xu, Gordon C. Jones, Michael A. Young, Andrew Goodman, Crissy Kibic, Patricia Sheridan, Nancy Kadish, Denise Moline, Rachel Phillips, Michele Adkinson, David Creed, Tammy DeCoste, Debbie Gembala, Sally Hurst, Elizabeth M. King, Joy Knowles, Pamela McBride, Patricia Pangburn, Judy Preston, Karen T. Stokes, Patricia Tesch, Susan Wenmoth, Linda Galocy, Deanna Mandley, Gail Orvis, Alphonso Dial, Letitia Clark, Lawrence Cohen, Joanne Gerber, Carlos Jamis‐Dow, Erini Makariou, Edward R. Smith, Amy Garrett, Colleen McGuire, Sarah Neff, Tara Riley, Sara Cantrell, Glynis Marsh, Chrispina Wray, Baigalmaa Yondonsambuu, Ulander Giles, Morgan Ford, Venus Brown, Amy Lita Evangelista,
The National Lung Screening Trial (NLST) is a randomized multicenter study comparing low-dose helical computed tomography (CT) with chest radiography in the screening of older current and former heavy smokers for early detection of lung cancer, which is the leading cause of cancer-related death in the United States. Five-year survival rates approach 70% with surgical resection of stage IA disease; however, more than 75% of individuals have incurable locally advanced or metastatic disease, the latter ...
Radiological Society of North America
Vincent W.-S. Tseng, Jordan A. Tharp, Jacob Reiter, Weston Ferrer, David S. Hong, P. Murali Doraiswamy, Stefanie Nickels, Richard L. Schilsky, Jennifer L. Allen, Mary Ann Anderson, Kevin J. Anstrom, Luanne Gomes de Araújo, Kristine Arges, Kaveh Ardalan, Bob Baldwin, Suresh Balu, Mustafa R. Bashir, Manju Bhapkar, Robert Bigelow, T. C. Black, Rosalia Blanco, G. T. Bloomfield, Durga S. Borkar, Leah B. Bouk, L. Ebony Boulware, Nikki Brugnoni, Erin J. Campbell, Paul Campbell, Lawrence Carin, Tammy Jo Cassella, Tina Cates, Renee Montgomery, Victoria Christian, John Choong, Michael Cohen‐Wolkowiez, Elizabeth A. Cook, Scott W. Cousins, Andrew Crawford, Nisha Datta, Melissa A. Daubert, J. R. Davis, Jillian Dirkes, Isabelle Doan, Marie Dockery, Pamela S. Douglas, Shelly Duckworth, Ashley Dunham, Gary E. Dunn, Ryan Ebersohl, Julie Eckstrand, Vivienne Fang, Achille Flora, Emily Ford, L. John R. Foster, Elizabeth Fraulo, John French, Geoffrey S. Ginsburg, Cindy Green, L. Greene, Jeffrey T. Guptill, Donna Hamel, Jennifer B. Hamill, Chris Harrington, Robert W. Harrison, Larry V. Hedges, Brooke L Heidenfelder, Adrian F. Hernandez, Cindy Heydary, Tim Hicks, Lina Hight, D. E. Hopkins, Erich Huang, Gloria Huh, Jillian H. Hurst, Kelly Inman, Gemini Janas, Glenn Jaffee, Jennifer Johnson, Tiffanie Keaton, Michel G. Khouri, Daniel A. King, Jennifer Korzekwinski, Lynne Koweek, Anthony N. Kuo, Lydia Coulter Kwee, David Landis, Rachele K. Lipsky, Desireé López, Carolyn Lowry, Kelly Marcom, Keith Marsolo, Paige McAdams, Shannon J. McCall, Robert W. McGarrah, John McGugan, Dani Mee, Sabrena Mervin-Blake, Prithu Mettu, Mathias Meyer, John E. Meyers, Carol T. Miller, Rebecca J. Moen, Lawrence H. Muhlbaier, Michael Murphy, Ben C. Neely, L. Kristin Newby, Jayne Nicoldson, Hoang Lan Nguyen, Maggie Nguyen, Lori L. O’Brien, Sumru Önal, Jeremey O'Quinn, David C. Page, Neha J. Pagidipati, Kishan S. Parikh, Sharon Palmer, Bray Patrick‐Lake, Brenda Pattison, Michael J. Pencina, Eric D. Peterson, Jonathan Piccini, T Poole, Thomas J. Povsic, Alicia Provencher, Dawn Rabineau, A. Rich, Susan Rimmer, Fides R. Schwartz, A. Serafin, Nishant Shah, Svati Shah, Kelly J. Shields, Steven Shipes, Peter Shrader, Jon Stiber, Lynn Sutton, Geeta K. Swamy, Betsy Thomas, Sandra Torres, Debara L. Tucci, Anthony Twisdale, Brooke Walker, Susan L. Whitney, R C N Williamson, Lauren Wilverding, Charlene A. Wong, Lisa Wruck, Ellen Young, Jane Perlmutter, Sarah Krug, S. Whitney Bowman-Zatzkin, Sarah Krug, Themistocles L. Assimes, Vikram S. Bajaj, Maxwell Cheong, Millie Das, Manisha Desai, Alice C. Fan, Dominik Fleischmann, Sanjiv S. Gambhir, Garry E. Gold, François Haddad, David S. Hong, Curtis P. Langlotz, Yaping Joyce Liao, Rong Lü, Kenneth W. Mahaffey, David J. Maron, Rebecca McCue, Rajan Munshi, Fátima Rodríguez, Sumana Shashidhar, George W. Sledge, Susie Spielman, Ryan Spitler, Sue Swope, Donna Williams, Carl J. Pepine, John D. Lantos, Michael Pignone, Patrick J. Heagerty, Laura M. Beskow, Gordon R. Bernard, Kelley Abad, Giulia Angi, Robert M. Califf, Lawrence Deang, J. Huynh, Manway Liu, Cheng‐Jie Mao, Michael Magdaleno, William J. Marks, Jessica L. Mega, D. Craig Miller, Nicole T. Ong, Dipen Patel, Vanessa K. Ridaura, Scarlet Shore, Sarah Short, Michelle Tran, Vũ Hoàng Vũ, Celeste Wong, Robert C. Green, John Hernandez, Jared F. Benge, Gislia Negrete, Gustavo Sierra, Terry Schaack,
The Patient Health Questionnaire 9 (PHQ-9) is the current standard outpatient screening tool for measuring and tracking the nine symptoms of major depressive disorder (MDD). While the PHQ-9 was originally conceptualized as a unidimensional measure, it has become clear that MDD is not a monolithic construct, as evidenced by high comorbidities with other theoretically distinct diagnoses and common symptom overlap between depression and other diagnoses. Therefore, identifying reliable and temporally ...
Tópico(s): Functional Brain Connectivity Studies
2023 - Elsevier BV | Psychiatry Research