Shinji Kagawa, Tetsuo Koyama, Masashi Hosomi, Takashi Takebayashi, Keisuke Hanada, Fumiaki Hashimoto, Kazuhisa Domen,
We sought to examine the effects of constraint-induced movement therapy on spasticity in patients with hemiparesis after stroke in 10 patients with chronic hemiparesis in their upper extremities.Patients underwent a modified version of constraint-induced movement therapy (5 hours daily for 10 weekdays over 2 consecutive weeks). Motor function was assessed by the Fugl-Meyer Assessment, Wolf Motor Function Test, and the Motor Activity Log. Spasticity was assessed by the modified Ashworth scale and ...
Tópico(s): Stroke Rehabilitation and Recovery
2011 - Elsevier BV | Journal of Stroke and Cerebrovascular Diseases
Manabu Kinoshita, Shuichi Izumoto, Naoya Hashimoto, Haruhiko Kishima, Naoki Kagawa, Tetsuo Hashiba, Yasuyoshi Chiba, Toshiki Yoshimine,
Tópico(s): Acute Myeloid Leukemia Research
2008 - Springer Science+Business Media | Brain Tumor Pathology
Y. Akihara, Yumiko Shimoyama, Kazufumi Kawasako, M. Komine, Kazuko HIRAYAMA, Yumiko Kagawa, Tetsuo Omachi, Kazuya MATSUDA, Minoru Okamoto, Tsuyoshi KADOSAWA, Hiroyuki TANIYAMA,
Canine ovarian tumors (epithelial tumor, sex-cord stromal tumor, germ cell tumor) classifying into 9 histological types were examined immunohistochemically using placental alkaline phosphatase (PLAP), cytokeratin7 (CK7), desmin, S100, AE1/AE3, inhibin α, vimentin, and alfa feto-protein (AFP). The papillary and tubular types observed in epithelial tumors were immunoreactive for desmin and AE1/AE3. The papillary type was also immunoreactive for PLAP and CK7. The solid type, nest type, cord type, palisade ...
Tópico(s): Metastasis and carcinoma case studies
2007 - Japanese Society of Veterinary Science | Journal of Veterinary Medical Science
Y. Akihara, Yumiko Shimoyama, Kazufumi Kawasako, M. Komine, Kazuko HIRAYAMA, Yumiko Kagawa, Tetsuo Omachi, Kazuya MATSUDA, Minoru Okamoto, Tsuyoshi KADOSAWA, Hiroyuki TANIYAMA,
To clarify the immunohistochemical characteristics of canine ovarian cysts, 109 canine ovarian cysts (57 cysts of subsurface epithelial structures: SES, 26 graafian follicle cysts, 12 cystic rete ovarii and 14 cysts difficult to classify morphologically) were examined regarding their lining cells immunohistochemically using antibodies against placental alkaline phosphatase (PLAP), S100, inhibin alpha, desmin and AE1/AE3. Both cysts of SES and cystic rete ovarii had a positive immunoreaction to desmin ...
Tópico(s): Reproductive Physiology in Livestock
2007 - Japanese Society of Veterinary Science | Journal of Veterinary Medical Science
Jun Ohta, Takashi Tokuda, Keiichiro Kagawa, Tetsuo Furumiya, Akihiro Uehara, Yasuo Terasawa, Motoki Ozawa, Takashi Fujikado, Y. Tano,
In this article, the authors report on a retinal prosthesis smart stimulator that is biocompatible and fully compatible with a standard large-scale-integration (LSI) structure and that provides high-stimulation efficiency. Our stimulator is based on multimicrochip architecture. The stimulator has been specifically developed for retinal prostheses, but it could be applied to other neuroscience and clinical neuroengineering fields
Tópico(s): Photoreceptor and optogenetics research
2006 - IEEE Engineering in Medicine and Biology Society | IEEE Engineering in Medicine and Biology Magazine
Kouichi Wada, Motohiko Maruno, Tsuyoshi Suzuki, Naoki Kagawa, Tetsuo Hashiba, Yasunori Fujimoto, Naoya Hashimoto, Shuichi Izumoto, Toshiki Yoshimine,
Meningioma is the commonest brain tumor and many genetic abnormalities, such as the loss of chromosome 22q and the mutation of NF2, have been reported.These classical abnormalities were detected using Southern blot, PCR, fluorescence in situ hybridization and comparative genomic hybridization, but these methods examine only very limited regions or limited mapping resolution of the tumor genome. In this study, we used DNA microarray assay, which detects numerous genetic abnormalities simultaneously ...
Tópico(s): Meningioma and schwannoma management
2005 - Taylor & Francis | Neurological Research
Kouichi Wada, Motohiko Maruno, Tsuyoshi Suzuki, Naoki Kagawa, Tetsuo Hashiba, Yasunori Fujimoto, Naoya Hashimoto, Shuichi Izumoto, Toshiki Yoshimine,
Tópico(s): Bone Tumor Diagnosis and Treatments
2004 - Springer Science+Business Media | Brain Tumor Pathology
Y. Kagawa, Tetsuo Hatakeyama, Yoshio Tanaka,
Tópico(s): Neural dynamics and brain function
1974 - Elsevier BV | Journal of Sound and Vibration
K. Hirayama, Chihiro ENDOH, Yumiko Kagawa, Tetsuo Ohmachi, Takeshi Yamagami, Koji Nomura, Kenichi Matsuda, M. Okamoto, Hiroyuki TANIYAMA,
Amyloid-producing odontogenic tumors (APOTs) of the facial skin were diagnosed in 3 domestic cats. The neoplasms had the histopathological characteristics of the odontogenic tumor. The neoplastic cells were present in irregular islands, strands, and sheets. The peripheral neoplastic cells of the islands and strands were arranged in a palisading fashion, while the central cells were polyhedral to stellate and randomly arranged. Multiple spherules of homogeneous eosinophilic material were closely apposed ...
Tópico(s): Hedgehog Signaling Pathway Studies
2016 - SAGE Publishing | Veterinary Pathology
A piezoelectric effect has been observed in a cholesteric liquid crystal layer (an electric field effect type, a mixture of cholesteryl oleyl carbonate, cholesteryl chloride and cholesteryl nonanoate) [1]. The layer, subjected to shear vibration, generates an alternating electric potential of the same frequency as the exciting vibration. In the present paper an extension of these investigations is reported to cases with various mixing ratios and also to one of smectic liquid crystals (lecithin with ...
Tópico(s): Molecular spectroscopy and chirality
1977 - Elsevier BV | Journal of Sound and Vibration
Y. Kagawa, Tetsuo Hatakeyama, Yoshio Tanaka,
Tópico(s): Semiconductor Lasers and Optical Devices
1975 - Elsevier BV | Journal of Sound and Vibration
Y. Shimoyama, Y. Akihara, Doaa Kirat, Hidetomo Iwano, K. Hirayama, Yumiko Kagawa, Tetsuo Ohmachi, Kenichi Matsuda, M. Okamoto, Tsuyoshi KADOSAWA, Hiroshi Yokota, Hiroyuki TANIYAMA,
Solid tumors are composed of a heterogeneous population of cells surviving in various concentrations of oxygen. In a hypoxic environment, tumor cells generally up-regulate glycolysis and, therefore, generate more lactate that must be expelled from the cell through proton transporters to prevent intracellular acidosis. Monocarboxylate transporter 1 (MCT1) is a major proton transporter in mammalian cells that transports monocarboxylates, such as lactate and pyruvate, together with a proton across the ...
Tópico(s): Virus-based gene therapy research
2007 - SAGE Publishing | Veterinary Pathology
Yusuke Asano, Hiroaki Kagawa, Yoko Kano, Tetsuo Shiohara,
Background: Overt cytomegalovirus (CMV) disease is a serious viral infection that usually occurs in immunocompromised patients but rarely in immunocompetent patients.Cutaneous lesions, albeit rare, occur as late systemic manifestations of CMV infections and are usually fatal.Observations: We describe 2 patients with druginduced hypersensitivity syndrome (one end of a spectrum of severe drug eruptions) who subsequently developed cutaneous CMV ulcers at unusual sites, such as the trunk; this occurrence ...
Tópico(s): Immunodeficiency and Autoimmune Disorders
2009 - American Medical Association | Archives of Dermatology
Keiichiro Kagawa, Keiichi Isakari, Tetsuo Furumiya, Akihiro Uehara, Takashi Tokuda, Jun Ohta, Masahiro Nunoshita,
A newly designed pulse frequency modulation photosensor for use in retinal prosthesis is proposed and demonstrated. The pixel converts the intensity of incident light into biphasic current pulses at frequencies suitable for the electrical stimulation of retinal neurons. Experimental results showed that the device was sensitive over a dynamic range of input light of about 120 dB, and that photosensitivity could be varied from 0 dB to around −40 dB.
Tópico(s): Advanced Memory and Neural Computing
2003 - Institution of Engineering and Technology | Electronics Letters
Hiroaki Kagawa, Shô Asakura, Tetsuo Iino,
Bacterial hooks were partially purified from flagella isolated from Salmonella SJ25, by treatment with heat to depolymerize flagellar filaments and with n -butanol and calcium chloride to remove membranes. Antihook serum was obtained from a rabbit inoculated with a preparation of hooks. The serum contained antibodies directed against the flagellar filament and cell membrane. These antibodies could be removed from the serum by absorption with purified flagellar filaments and cells of a nonflagellated ...
Tópico(s): Biomedical Research and Pathophysiology
1973 - American Society for Microbiology | Journal of Bacteriology
Naoki Kagawa, Motohiko Maruno, Tsuyoshi Suzuki, Tetsuo Hashiba, Naoya Hashimoto, Shuichi Izumoto, Toshiki Yoshimine,
Tópico(s): Cancer-related molecular mechanisms research
2006 - Springer Science+Business Media | Brain Tumor Pathology
Keiichiro Kagawa, K. Yasuoka, David C. Ng, Tetsuo Furumiya, Takashi Tokuda, Jun Ohta, Masahiro Nunoshita,
A new architecture for pixel-level parallel image processing in the pulse domain for CMOS vision chips has been developed. Image processing such as edge enhancement, edge detection, and blurring are realized based on suppression and promotion of digital pulses; the pixel value is represented by the frequency of digital pulses by use of a pulse-frequency modulation (PFM) photosensor or that with an in-pixel 1-bit analog-to-digital converter. The proposed architecture is suitable for low-voltage operation ...
Tópico(s): Advanced Memory and Neural Computing
2004 - IEEE Photonics Society | IEEE Journal of Selected Topics in Quantum Electronics
K. Yasui, Ryota Kondou, Akira Iizuka, Haruo Miyata, Emiko Tanaka, Tadashi Ashizawa, Takeshi Nagashima, Keiichi Ohshima, Kenichi Urakami, Masatoshi Kusuhara, Koji Muramatsu, Takashi Sugino, Ken Yamguchi, Keita Mori, Hideyuki Harada, Tetsuo Nishimura, Hiroyasu Kagawa, Yushi Yamakawa, Hitoshi Hino, Akio Shiomi, Yasuto Akiyama,
Abstract The aim of the study was to investigate the effect of chemo-radiation on the genetic and immunological status of rectal cancer patients who were treated with preoperative chemoradiotherapy (CRT). The expression of immune response-associated genes was compared between rectal cancer patients treated (n = 9) and not-treated (n = 10) with preoperative CRT using volcano plot analysis. Apoptosis and epithelial-to-mesenchymal transition (EMT) marker genes were analysed by quantitative PCR (qPCR). Other ...
Tópico(s): Colorectal and Anal Carcinomas
2020 - Oxford University Press | Journal of Radiation Research
Shuichi Izumoto, Akihiro Tsuboi, Yoshihiro Oka, Tsuyoshi Suzuki, Tetsuo Hashiba, Naoki Kagawa, Naoya Hashimoto, Motohiko Maruno, Olga A. Elisseeva, Toshiaki Shirakata, Manabu Kawakami, Yusuke Oji, Sumiyuki Nishida, Satoshi Ohno, Ichiro Kawase, Jun Hatazawa, Shin‐ichi Nakatsuka, Katsuyuki Aozasa, Satoshi Morita, Junichi Sakamoto, Haruo Sugiyama, Toshiki Yoshimine,
Object The object of this study was to investigate the safety and clinical responses of immunotherapy targeting the WT1 (Wilms tumor 1) gene product in patients with recurrent glioblastoma multiforme (GBM). Methods Twenty-one patients with WT1/HLA-A*2402–positive recurrent GBM were included in a Phase II clinical study of WT1 vaccine therapy. In all patients, the tumors were resistant to standard therapy. Patients received intra-dermal injections of an HLA-A*2402–restricted, modified 9-mer WT1 peptide ...
Tópico(s): CAR-T cell therapy research
2008 - American Association of Neurological Surgeons | Journal of neurosurgery
Shuichi Izumoto, Tsuyosi Suzuki, Manabu Kinoshita, Tetsuo Hashiba, Naoki Kagawa, Kouichi Wada, Yasunori Fujimoto, Naoya Hashimoto, Youichi Saitoh, Motohiko Maruno, Toshiki Yoshimine,
Although craniopharyngiomas have a histologically benign nature, their treatment can be difficult. The correlation among clinical, proliferative, and immunohistologic features of female sex hormone receptors was determined in craniopharyngiomas to analyze whether they influence the growth of the tumor. The study subjects were 43 patients with previously untreated craniopharyngioma who underwent surgery at our department over the past 15 years. Serial tissue sections were immunostained with the antibodies ...
Tópico(s): Adrenal and Paraganglionic Tumors
2005 - Elsevier BV | Surgical Neurology
Takeshi Shimoda, Yoshitake Kagawa, Kotaro Mori, Norihide Hinomoto, Tadashi Hiraoka, Tetsuo Nakajima,
Tópico(s): Study of Mite Species
2017 - Springer Science+Business Media | BioControl
Keizo Sekiya, Tsutomu Fushimi, Tetsuo Kanamori, Naoyuki Ishikawa, Masamitsu Itoh, Makoto Takita, T. Nakanishi,
... Ministry of Agriculture, Forestry, and Fisheries, Senyu, Zentsuji, Kagawa 765, Japan Search for other works by this author on: Oxford Academic Google Scholar Tetsuo Kanamori, Tetsuo Kanamori Shikoku National Agricultural Experiment Station, Ministry of Agriculture, Forestry, and Fisheries, Senyu, Zentsuji, Kagawa 765, Japan Present address: National Agriculture Research Center, ...
Tópico(s): Postharvest Quality and Shelf Life Management
1993 - Oxford University Press | Bioscience Biotechnology and Biochemistry
Kiriko Inoue, Yoko Kano, Hiroaki Kagawa, Kazuhisa Hirahara, Tetsuo Shiohara,
Auteur(s) : Kiriko Inoue, Yoko Kano, Hiroaki Kagawa, Kazuhisa Hirahara, Tetsuo Shiohara Department of Dermatology, Kyorin University School of Medicine, 6-20-2 Shinkawa Mitaka, Tokyo, 181-8611 Japan Recent studies by Aurelian and ...
Tópico(s): Herpesvirus Infections and Treatments
2009 - John Libbey Eurotext | European Journal of Dermatology
Harumi Kagawa, Tetsuo Hayashi, Jun Tanimoto, Tadahisa KATAYAMA,
Lawn covered earth surface has passive cooling effects and mitigates the hot environment in summer with its evapotranspiration mechanism. Soil covered roofs might decrease the cooling-load of buildings. Quantitative investigation of hygrothermal characteristics of lawn and soil surfaces is indispensable for the utilization of these effects. Eight test pieces, therefore, of lawn and bare soil surfaces have been observed to identify their hygrothermal characteristics since August of 1995 on the roof ...
Tópico(s): Hygrothermal properties of building materials
1998 - Architectural Institute of Japan | Journal of Architecture and Planning (Transactions of AIJ)
Yasunori Fujimoto, Naoya Hashimoto, Manabu Kinoshita, Yuko Miyazaki, Satoshi Tanaka, Takayuki Yakushijin, Tetsuo Takehara, Naoki Kagawa, Toshiki Yoshimine,
Tópico(s): Polyomavirus and related diseases
2011 - Springer Science+Business Media | International Journal of Clinical Oncology
Tetsuo Hashiba, Shuichi Izumoto, Naoki Kagawa, Tsuyoshi Suzuki, Naoya Hashimoto, Motohiko Maruno, Toshiki Yoshimine,
The expression of Wilms' tumor gene WT1 protein was investigated immunohistochemically in 73 glial tumors, including 60 astrocytic tumors, eight oligodendroglial tumors, and five ependymal tumors. WT1 protein was detected in 70 of the 73 glial tumors (95.9%) examined. Almost all glioblastomas, anaplastic astrocytomas, anaplastic ependymomas, and anaplastic oligodendrogliomas expressed high levels of WT1 protein. A significant (p < 0.001) correlation was found between WT1 protein expression and MIB-1 ...
Tópico(s): Renal cell carcinoma treatment
2007 - Japan Neurological Society | Neurologia medico-chirurgica
This paper deals with the optical transmission and the dielectric effects in a nematic liquid crystal film (MBBA) of homeotropic state subjected to ultrasound. As in the case of the application of shear vibration, it is found that not only the transmitted light intensity through the film but also the dielectric constant and the tanδ of the film change with ultrasound intensity. There exists a threshold sound pressure above which the effects are appreciable. The threshold sound pressure is almost ...
Tópico(s): Optical Polarization and Ellipsometry
1976 - Elsevier BV | Journal of Sound and Vibration
Miwako Kagawa, Yasuteru Fujino, Naoki Muguruma, Noriaki Murayama, Koichi Okamoto, Shinji Kitamura, Tetsuo Kimura, Kazuhiro Kishi, Hiroshi Miyamoto, Hisanori Uehara, Tetsuji Takayama,
Tópico(s): Pancreatitis Pathology and Treatment
2016 - Springer Science+Business Media | Clinical Journal of Gastroenterology
Yoshiro Imai, Kazuki Higashikakiuchi, Akira Nakayama, Koji Kagawa, Kazuaki Ando, Tetsuo Hattori,
Computer system has been evolving rapidly. Inside of such a computer system becomes complicated and difficult for beginners to understand easily because it is invisible like a blackbox. We have thought that one of the solutions is to explain graphically and demonstrate its inside for beginners to learn efficiently. In this study, we have developed another Web-based computer simulator with JavaScript, and then evaluated it in our classroom lecture by questionnaires and in assembly programming exercise. ...
Tópico(s): Higher Education and Teaching Methods
2017 - | IEEJ Transactions on Electronics Information and Systems
Tsuneo Tanaka, Yasuhiro Matsugu, Masahiro Matsuda, Tatsuro Ishimoto, Naoki Kagawa, Hideki Nakahara, Tetsuo Ishikawa, Yasuhiko Fukuda,
【目的】高齢者における消化器手術のリスク評価法としてPOSSUM scoreの有用性について検討した.【方法】1996年から2003年までに全麻下に手術を行った80歳以上の高齢者251例を対象とした.術後合併症のあり群(n=88)となし群(n=163)に分けて,術前因子,血液データ,手術因子, POSSUMの検討を行った.【結果】0.1%以下の有意差が認められた項目は白血球数,緊急手術,腹膜炎,およびPOSSUMのphysiological score (PS), operative severity score (OS), predicted mortality rate, predicted morbidity rateの7項目であった. PS 25点以上をhigh riskとすると,術後合併症発生率はhigh risk groupでは45/64 (70%)であり, low risk group (43/187, 23%)にくらべて有意に高率であった.【結論】高齢者における消化器手術のリスク評価の指標としてPOSSUM scoreは有用である.術前のPSにより術後合併症発生率のhigh risk ...
Tópico(s): Abdominal Surgery and Complications
2004 - Japan Surgical Association | Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)