Phil Yates, Jon Ashworth, Edward Gorman, Sailing Correspondent, Helen Johnstone, Joanna Hunter, Andrew Stevenson, Nick Nuttall, Robert Cole, Andrew Pierce, Zahid Hussain, Rob Hughes, Sarah Potter, Richard Ford, Home Correspondent, Alice Lagnado, James Bone and David Lister, Paul Hoggart, John O'Leary, Education Editor, Gavin Lumsden, Raymond Snoddy, Media Editor, Michael Evans Defence Editor, Philip Howard, Caroline Merrell, Banking Correspondent, Jeremy Kingston, Joanna Bale, James Bone, Alan Hawkes, Alexandra Frean Social Affairs Correspondent, Jenni Hall, Barbara Ellen, Nick Nuttall, Environment Correspondent, David Robinson and Perry Cleveland-Peck, Roland Watson, Chief Political Correspondent, Kevin Eason, Tim Rodber, Michael Cudlipp, Raymond Snoddy, Robert Sheehan, Bridge Correspondent, Gerald Davies, Stefan B. Tietz, Giles Coren, Michael Gaisford, Richard Duce and Russell Jenkins, Valerie Hanaway, Cornelius Lysaght, Donald Laming, David Litchfield, Dominic Walsh, Jim McCue, Raymond Keene Chess Correspondent, John Street, David Conway, Michael Harvey, Martin Barrow, Dalya Alberge Arts Correspondent, Richard Ford Home Correspondent, Alan Hamilton, Robin Young, Mark Inglefield, Ian Hughes, William Critchley, Valerie Elliott Consumer Editor, Charles Bremner, Michael Leapman, Fiona Fleck, Peter Barnard, Salman Rushdie, Paula Hawkins, John Humphrys, Robert Cole City Correspondent, Martin Fletcher and James Landale, Nigel Williamson, Richard Cork, Michael Dynes Africa Correspondent, Paul Durman, Sydney Friskin, John Hopkins, Jill Sherman and Roland Watson, Tom Baldwin and Melissa Kite, Chris Patten, Stephen Wood, Adam Jones, Raymond Keene, Zahid Hussain and David Orr, Clive Mathieson, Matthew Pryor, David Coates, Philip Webster and Roland Watson, Paul Wilkinson, Stefano Hatfield, Ray Connolly, David Orr, Mary Ann, Francis Gilbert, Caroline Merrell, Carl Mortished, International Business Editor, Christopher Walker Chief Ireland Correspondent, Cathy Harris, Hettle Judah, Richard Owen, Damian Whitworth, Christopher Martin-Jenkins Chief Cricket Correspondent, Tony Patrick and Louise Godfrey, Oliver August, Nick Hasell, Jennifer O'neill, Lea Paterson and Christine Buckley, Dalya Alberge, David Hands Rugby Correspondent, Alison Kervin, Rugby Editor, John Allison, John Goodbody, Giles Whittell, Nick Nuttall, Technology Correspondent, Christopher Walker, Simon De Bruxelles, Saeed Shah, Jane Shilling, Alex O'Connell, Brian MacArthur, Mel Webb, George Caulkin, Melissa Kite Political Reporter, John Eddison, Caitlin Moran, Peter Riddell, Ben MacIntyre, Ian Brodie, John Mair, Bill Cash, David Sinclair, Simon Jenkins, Fraser Nelson, Tim Jones, Michael Binyon, Diplomatic Editor, Martin Waller, Nigel Hawkes Science Editor, Carl Mortished International Business Editor, Mark Baldwin, Benedict Nightingale, Alexandra Frean, Social Affairs Correspondent, Margaret Owles, Frances Gibb, Legal Editor, Stephen Dalton, Helen Rumbelow, Medical Reporter, John Stevens, Sam Kiley, Richard Morrison, Tom Baldwin Deputy Political Editor, Jo Wagerman, Allan Hall, Robert Whymant, Alan Lee Racing Correspondent, Lea Paterson Economics Correspondent, Sally Patten, Robin Baird-Smith's, Peter Roebuck, Lisa Verrico, Richard Pankhurst,
... City Diary UK-iNvest. com Employers are always the winners with pension funds DTI retail price study unaffected Stealthy Brown Microsoft and BT in mobile alliance Time continues to drag for luxury watchmaker Cornhill Insurance Battle for Kirk over replicator claim Intel adds DSP to its stable for $ ...
1999 - Gale Group | TDA
... ORC is required for the fundamental function of replicators: the ability to direct origin unwinding. The distinct features ... that bind near the ACS of a particular replicator. The HMR-E silencer in yeast is a member ... ACS was referred to as the non-silencer replicator. Since the ACS in HMR-E is dispensable for silencing ... that the synthetic silencer is the only functional replicator in the vicinity of an HMR locus lacking the HMR- ...
Tópico(s): Genomics and Chromatin Dynamics
1999 - Springer Nature | The EMBO Journal
Bernard Piette, Jonathan G. Heddle,
... even simpler self replicators; that is, molecular self-replicators. The first such replicator is referred to as the ... again increasing survival likelihood. For an RNA-only replicator, the story is less convincing. A self-replicating RNA ... a functional peptide. We then come close to the nucleopeptide replicator outlined in Figure 1; the difference being that the system in Figure 1 ...
Tópico(s): DNA and Biological Computing
2020 - Elsevier BV | Trends in Ecology & Evolution
... are relatively abundant, appear to bind specifically to replicators. The levels of MCM proteins are estimated to be ... another component of the replisome that assembles at replicators during G1. The identification of components of the pre-RC is ...
Tópico(s): Fungal and yeast genetics research
1997 - Cell Press | Cell
Shuo Yang, Yannick Geiger, Marc Geerts, Marcel Eleveld, Armin Kiani, Sijbren Otto,
... a relatively small number of chiral units in the replicators (down to eight) and in the precursors (down ... enantioselectivity depends on structural features (ring size of the replicator) that appear to impose constraints on its supramolecular organization. This work reveals new aspects of the little researched interplay between chirality and self-replication ...
Tópico(s): Protein Structure and Dynamics
2023 - American Chemical Society | Journal of the American Chemical Society
Marcell Dodard Julien, Zhanna Polonskaya, Janet Hearing,
... association of the ORC subunit Orc2 with the replicator. The minimal replicator of oriP consists of two EBNA- ... We show that nucleotide differences between the oriP replicator of the B95-8 and Raji EBV genomes are not ...
Tópico(s): Polyomavirus and related diseases
2004 - Elsevier BV | Virology
... spatially constrained catalytic cooperation among RNA-like modular replicators. The necessary spatial constraints might have been supplied by ... the mineral substrate surface of both the macromolecular replicators and the small molecules of metabolites they produce catalytically are ... determining the stable persistence of an evolvable metabolic replicator community.The effects of replicator mobility and metabolite diffusion on ... are determined, including the maximum attainable size of the metabolic replicator system and its resistance to the invasion of ...
Tópico(s): Photoreceptor and optogenetics research
2013 - Springer Science+Business Media | BMC Evolutionary Biology
... B2 elements are also present in the ARS307 replicator. The B3 element binds a replication and transcription enhancer ... DNA binding assay to study the interaction between replicators and the putative initiator protein ORC. In addition to the ...
Tópico(s): CRISPR and Genetic Engineering
1995 - National Academy of Sciences | Proceedings of the National Academy of Sciences
John Wilkins, Clem Stanyon, Ian F. Musgrave,
... life. However, at that stage there were no replicators, and the distinction between interactors and replicators did not yet apply. Nevertheless, the process of evolution that proceeded from initial autocatalytic ... the more generic category of Darwinian evolution on the other. We argue that Hull's and Dawkins' replicator/interactor distinction of entities is a sufficient, but not necessary, condition for Darwinian evolution to take place. We conceive the origin of genes as a separation between different ...
Tópico(s): Evolution and Genetic Dynamics
2011 - Springer Science+Business Media | Biology & Philosophy
... contains the TRP1 gene and a yeast chromosomal replicator. The TRP1 gene has been located on the fragment ... homologies with analogous areas surrounding other yeast genes. The yeast replicator has been localized in a region near the 3′ end of the TRP1 gene. The DNA ...
Tópico(s): Ferrocene Chemistry and Applications
1980 - Elsevier BV | Gene
Fu‐Jung Chang, James F. Theis, J. Miller, Conrad A. Nieduszynski, Carol S. Newlon, Michael Weinreich,
... replicating sequence (ARS) elements that function as chromosomal replicators. The essential 11-bp ARS consensus sequence (ACS) that ... an Abf1p binding site. Although a largely inactive replicator on the chromosome, ARS318 becomes active if the nearby HMR- ... also performed a multiple sequence alignment of confirmed replicators on chromosomes III, VI, and VII. This analysis revealed a highly conserved WTW motif 17 to 19 bp from the ACS that is functionally important and is apparent ...
Tópico(s): CRISPR and Genetic Engineering
2008 - Taylor & Francis | Molecular and Cellular Biology
Tamara Kosikova, Douglas Philp,
... between the kinetic and thermodynamic parameters of the replicators, the initial reagent concentrations, and the presence or absence ... establish the rules that govern the behavior of the competing replicators under conditions where their formation is coupled tightly to the processing of a DCL.
Tópico(s): Origins and Evolution of Life
2019 - American Chemical Society | Journal of the American Chemical Society
Luoer Chen, Churou Deng, Manh Hong Duong, The Anh Han,
In this paper, we consider the replicator-mutator dynamics for pairwise social dilemmas where the payoff entries are random variables. The randomness is incorporated to take into account ... We analytically and numerically compute the probability that the replicator-mutator dynamics has a given number of equilibria for four classes of pairwise social dilemmas (Prisoner’s Dilemma, Snow-Drift Game, Stag-Hunt Game and Harmony Game). As a result, we characterise the qualitative behaviour of such probabilities as a function ...
Tópico(s): Opinion Dynamics and Social Influence
2024 - Elsevier BV | Chaos Solitons & Fractals
Cyril M. Sanders, Arne Stenlund,
... A)Structure of the BPV-1 minimal origin (replicator). The minimal ori spans 59 bp (BPV-1 genome ...
Tópico(s): RNA Interference and Gene Delivery
1998 - Springer Nature | The EMBO Journal
Douwe Molenaar, Rogier van Berlo, Dick de Ridder, Bas Teusink,
... section. The basic properties of an optimized self-replicator The fact that current growth models consider only part ... itself. The ensemble of reactions constitutes a self-replicator. We assume a steady state in the system, called 'balanced growth' (Ingraham et al, 1983). ... Figure 3.Optimal regulation of a basic self-replicator, consisting of four enzymes and a membrane. The cell (A) consists of a pool of ribosomes ...
Tópico(s): Algal biology and biofuel production
2009 - Springer Nature | Molecular Systems Biology
... applications disseminate state and control information through a replicator. The replicator mainly limits distribution of messages based on expressed interest of other applications, thus implementing an application-level, receiver-driven local multicast. It also automatically starts applications as needed. The same functionality was also implemented IP multicast restricted ...
Tópico(s): Service-Oriented Architecture and Web Services
1995 - Springer Science+Business Media | Lecture notes in computer science
Nobuto Takeuchi, Paulien Hogeweg,
... evolution of complexity in a simulated RNA-like replicator system. The simplicity of the system allows us to explicitly ... of genotypes (information) or the ecological organization of replicators in the model. In particular, the model assumes that interactions ... crucially depends on the spatial pattern formation of replicators. Finally, the evolutionary dynamics is shown to significantly depend on ...
Tópico(s): Evolutionary Game Theory and Cooperation
2008 - BioMed Central | Biology Direct
David G. Quintana, Zhi-hui Hou, Kelly C. Thome, Marvin Hendricks, Partha Saha, Anindya Dutta,
... sequences and whether such sequences constitute true human replicators. The work reported in this paper was undertaken during ...
Tópico(s): Bacterial Genetics and Biotechnology
1997 - Elsevier BV | Journal of Biological Chemistry
Benjamin D. Lee, Eugene V. Koonin,
... unlikely to be direct descendants of primordial RNA replicators, the study of the diversity and evolution of these ...
Tópico(s): Chromosomal and Genetic Variations
2022 - Multidisciplinary Digital Publishing Institute | Life
Josep Sardanyés, Ricard V. Solé,
... associated to the increase of the length of the replicators. Such diversity, jointly with the inclusion of spatial degrees of freedom and mutation, ...
Tópico(s): Mathematical and Theoretical Epidemiology and Ecology Models
2007 - World Scientific | International Journal of Bifurcation and Chaos
Sophie Juliane Veigl, Javier Suárez, Adrian Stencel,
... of the unit of heredity, such as the replicator, the reproducer, and the Darwinian individual. We argue that ...
Tópico(s): Evolutionary Game Theory and Cooperation
2022 - Springer Science+Business Media | Synthese
... of the conformational degrees of freedom of the replicators, the mechanisms of which remain unclear. In addition, realistic ...
Tópico(s): RNA and protein synthesis mechanisms
2013 - Elsevier BV | Biosystems
Kirsten Skarstad, Erik Boye, Ellen Fanning,
... represents the replicon, the square box represents the replicator, and the arrow indicates where the initiator protein is encoded, ... on specific intergenic DNA sequences to act as replicators, whereas the huge intergenic regions of metazoan genomes offer these ...
Tópico(s): Plant Disease Resistance and Genetics
2003 - Springer Nature | EMBO Reports
John Grummitt, Stephen Satchell,
... years. We find a reasonable match between the replicator and the Dow CSFB index of self-reporting hedge funds. ... returns are closer to the returns of the replicator than the index of reported returns. We seek to explain ...
Tópico(s): Stock Market Forecasting Methods
2011 - Palgrave Macmillan | Journal of Derivatives & Hedge Funds
... the chromosomes of Ch. lineage had late DNA replicators in the proximal regions, while most of the chromosomes of Ch. nipponicum had late DNA replicators in the distal regions. The satellites of the three chromosomes of Ch. lineage were middle replicators, while the satellites in the chromosomes of Ch. nipponicum were found to be late replicators. At all stages in the DNA synthetic phase the chromosomes of Ch. lineage ... the relationship between morphologically different heterochromatic regions and the late replicators, as well as to the relationship of chromosome ...
Tópico(s): Photosynthetic Processes and Mechanisms
1966 - Botanical Society of Japan | Shokubutsugaku Zasshi
Tamás Czárán, Balázs Könnyű, Eörs Szathmáry,
... spite of the different replicabilities of the cooperating replicators; the other is constraining parasitism, i.e., keeping "cheaters" ...
Tópico(s): Protein Structure and Dynamics
2015 - Elsevier BV | Journal of Theoretical Biology
Rikuto Kamiura, Ryo Mizuuchi, Norikazu Ichihashi,
... host replicator that is resistant to the parasitic replicator. However, the feasibility of such complexification with biologically relevant molecules ... most plausible complexification pathway from a single host replicator is the addition of a parasitic replicator, followed by the addition of a new host replicator that is resistant to the parasite, consistent with the previous study by Takeuchi ...
Tópico(s): Evolutionary Game Theory and Cooperation
2022 - Public Library of Science | PLoS Computational Biology
Victoria C. Allen, Craig C. Robertson, Simon Turega, Douglas Philp,
... network is an excess of one of the replicators whenever the input contains either or both of the replicators, mirroring the OR boolean logic operation.
Tópico(s): Distributed systems and fault tolerance
2010 - American Chemical Society | Organic Letters
... are a far cry from Star Trek's replicators, the capabilities of the current technology--in terms of ... flung future. Released in January of 2012, (6) the MakerBot Replicator consumer-level 3D printer sold 5,500 units by the end of August 2012, out of a total ...
Tópico(s): Law, AI, and Intellectual Property
2012 - The MIT Press | Harvard journal of law & technology
Ann Dershowitz, M Snyder, Mohammed Sbia, Joan Skurnick, Loke Y. Ong, Carol S. Newlon,
... chromosome occurred only after all five efficient chromosomal replicators in the left two-thirds of the chromosome (ARS305, ARS306, ... rate. Chromosome fragmentations that removed the normally inactive replicators on the left end of the chromosome or the replicators distal to ARS310 on the right arm showed that both groups of replicators contribute significantly to the maintenance of the originless chromosome. Surprisingly, a 142- ... telomeres or a linear topology were required for the maintenance of chromosome fragments lacking replicators.
Tópico(s): Microtubule and mitosis dynamics
2007 - Taylor & Francis | Molecular and Cellular Biology