Lea Paterson and Susan Emmett, Jon Ashworth, Malcolm Oliver, Cath Urquhart, David Adams, Stella Shamoon, Gillian Rowe, Nick Nuttall Environment Correspondent, Robert Cole, Portia Colwell, nigella lawson, Andrew Pierce, Sally Brock, James Moore, Grace Bradberry, Rob Hughes, Sarah Potter, Duncannon, Jane MacQuitty, Gary Neville, John Morgan, Clive King, Brian Stewart, Paul Hoggart, Mark Souster, Emma Haughton, Richard Hobson, rebecca gibbon, Karen Woolfson, Geoffrey MacNab, Robert Lea, D. W. C. Green, Gavin Lumsden, Douglas Friedli, Philip Howard, Caroline Merrell, Banking Correspondent, Michael Binyon, Michael Evans and Christopher Walker, James Bone, Paul Farrow, Clive Davis, Katie Lovell, matt herring, Paul Solotaroff, Ian Cundell, Christopher Hunt, Carl Mortished, Anne Robinson, James Allcock's, Angus Clarke and Kirsty, Richard Miles and Paula Hawkins, John Bungey, Stewart Tendler, Crime Correspondent, Roland Watson, Chief Political Correspondent, James Eve, john diamond, Raymond Snoddy, Clare Stewart, Antonia Senior, Carl Evans, David McVay, Stephen McClarence, Christine Buckley, Nick Nuttall and Robert Whymant, Thorsons, D. R., Steve Keenan, Melanie Tringham, Annabel Karmel, Dominic Walsh, Ruth Gledhill, Jerome Boyd Maunsell, Gary Jacob, Mike Pattenden, Marina Warner, Alix Ramsay Tennis Correspondent, E. C., Dalya Alberge Arts Correspondent, Philip Webster and Lea Paterson, Peter Hughes, Jo Morris, EJ, Robin Young, Oliver Wright, Hugh Shuttleworth, Gerry Adams, Stephanie Churchill's, Frances Bissell, Geoff Yeates, David Hands, P. B., Jill Sherman, Whitehall Editor, Adrian Yalland (Chairman), Sarah Millar, Peter Barnard, Frederick Clough, Lawrie Holmes, Nicholas Wapshott, Anthea Lawson, Paul McCann, Media Correspondent, Derwent May, Tim Teeman, Stuart Bailie, Friedrich Reck-Malleczewen, VW, Paula Hawkins, Russell Kempson, mike goldwater, Emma Mahony, Louise Christian, Mary Gold, Daniel McGrory, Paul Armstrong, Ed Potton, Richard Colwill, Amber Cowan, Julian Marr, Michael Theodoulou, Frederick Clogh, Edmund Burke, John Hopkins, Michael Dynes, Africa Correspondent, Alasdair Mitchell, Michele Hanson, Rob Wright, MH, Michael Ross, Raymond Keene, Adam Sage, David Robinson, John Russell Taylor, Matt Dickinson, Tom Baldwin, Deputy Political Editor, Lucy Pinney, Alison Kervin Rugby Editor, Martin Jackson, Francis Gilbert, Phil Shirley, Min Cooper, Nigel Hawkes, Clive Petty, Arabella Warner, Dave Roberts, Chris Ayres Media Business Correspondent, Cathy Harris, Jo Carlowe, Hettle Judah, Richard Owen, Oliver Holt, David Powell, Athletics Correspondent, Roger Maynard and Michael Harvey, Michael Harvey and Stewart Tendler, Damian Whitworth, Helen Nugent, Marcel Berlins, Roger Boyes, Valerie James, Emily Davies, John Cherry, Nick Hasell, Ian Murray Medical Correspondent, Tom Baldwin and Philip Webster, James Hawes, Robert Cole, City Correspondent, rob stuart, Glen Owen, Ben Hammersley, Devsiri P. Hewavidana, James Doran, Giles Whittell, Jeff Clarke, James Pringle, Valerie Elliott, Countryside Editor, CK, Mel Webb, Srikumar Sen Boxing Correspondent, William Oddie, Deborah King, Susan Elkin, Matthew Parris, PW, Elizabeth Rowlands, George Caulkin, Millett, Chris McGrath, Gordon Ford, Russell Jenkins, Tim Wapshott, Johnny Acton, AS, Simon Brooke, Jane Owen, Ben MacIntyre, Hunter Davies, Helen Pridham, Quintin Wright, Jeremy Wayne, Graham Searjeant, Richard Miles, Fraser Nelson, Mark Colegate, Donald Brown, Martin Waller, Elizabeth Cowley, Michael Horsnell, Tim Evans, Chris Ayres, Danny Baker, Lucas Mellinger, Fran Littlewood, Jeffrey Joy, Laura Peek, Kathleen Wyatt, Benedict Nightingale, Oliver Wright and Adam Sherwin, J. Lund, Jeremy Fox, Jill Crawshaw, SR, Alyson Rudd, David Powell, Tom Chesshyre, Paul Connolly, Elizabeth Buchan, Valerie Grove, Adam Sherwin, SJ, Claire Burston, Susie Steiner, Anne C. ELLIS(Assistant Secretary), Sally Patten, Andrew Michael, Penny Perrick, Alec L. Parrott, Jan Raath, Edward Gorman Sailing Correspondent, Walter Ellis, David Hands, Rugby Correspondent, Lea Paterson, Economics Correspondent, Christine Buckley, Industrial Correspondent, Richard WHITFIELD(Chairman), Susan Emmett,
... No Title Thanksgiving Services Doris Coley Member of the Shirelles all-girl pop group that put the sex into romance Multiple Classified Advertising Items Gifts ...
2000 - Gale Group | TDA
... 1960s girl groups such as the Marvelettes, the Shirelles and the Shangri-Las through an examination of approximately two ...
Tópico(s): Media, Gender, and Advertising
2003 - Cambridge University Press | Popular Music
... requests for men to voice these words, by the Shirelles and other groups. This is the first sense in which the girl‐groups can ...
Tópico(s): Music History and Culture
2005 - Taylor & Francis | Popular Music & Society
... key hitmakers like the Ronettes, the Supremes, and the Shirelles - studies of girl-group music that address race, gender, class, and sexuality have only just begun to appear. Warwick is the first writer to address '60s girl group music ...
Tópico(s): Diverse Music Education Insights
2007 - Association of College and Research Libraries | Choice Reviews Online
... And Future.” Red Bird 10–068, 1966, Vinyl. Shirelles, The. “ Doomsday.” Scepter 1278, 1964, Vinyl. Shirelles, The. “ Mama Said.” Scepter 1217, 1961, Vinyl. Shirelles, The. “ Soldier Boy.” Scepter 1228, 1962, Vinyl. Shirelles, The. “ Tonight's the Night.” Scepter 1207, 1960, Vinyl. Shirelles, The. “ What Does a Girl Do?” Scepter 1255, 1963, Vinyl. Shirelles, The. “ Will You Love Me Tomorrow?” Scepter 1211, 1960, Vinyl. Shirelles, The. Will You Love Me Tomorrow?—The Anthology. Castle ...
Tópico(s): Theater, Performance, and Music History
2012 - Wiley | Journal of Popular Music Studies
... participants—the Platters, the Drifters, the Coasters, the Shirelles. In the UK, this option was largely overlooked until the ...
Tópico(s): Historical and Scientific Studies
2006 - Wiley | Journal of Popular Music Studies
... of groups such as the Shangri-Las, the Shirelles, the Ronettes, the Crystals, and the Marvelettes ‘that emerged ...
Tópico(s): Music History and Culture
2009 - University of Toronto Press | University of Toronto Quarterly
... Queen of Rock and Roll") and 3 ("Remembering the Shirelles") engage extensively with race by articulating the expectations ... soloist LaVern Baker and the teenage girl group the Shirelles. Mahon surveys Baker's treatment (or lack thereof) in college textbooks, rock-and-roll readers, and women-inmusic texts, noting even her own neglect of Baker in an earlier edited collection on the history of African American music (pp. 53–54). ...
Tópico(s): Music History and Culture
2021 - Music Library Association | Notes
... about the early 1960s all-female group the Shirelles, Mahon shifts the focus away from a version of rock authenticity ...
Tópico(s): Theater, Performance, and Music History
2021 - Wiley | Journal of Popular Music Studies
Demetrius Oliver, Robert Pruitt, Joseph Havel, Dario Robleto, Trenton Doyle Hancock, David McGee, John Thomas Biggers, Jean Lacy, Mequitta Ahuja, Dawolu Jabari Anderson,
... Civil War soldier constructed for himself, made from The Shirelles’ “Soldier Boy” melted vinyl record and femur bone dust, fitted inside a pair of WWI military cavalry boots made from Skeeter Davis’ “The End Of The World” melted vinyl record, oil ...
Tópico(s): American Sports and Literature
2009 - Johns Hopkins University Press | Callaloo
Shirelle X. Liu, Mari S. Gades, Yayi Swain, Aarthi Ramakrishnan, Andrew C. Harris, Phu V. Tran, Jonathan C. Gewirtz,
Opioid abuse is a chronic disorder likely involving stable neuroplastic modifications. While a number of molecules contributing to these changes have been identified, the broader spectrum of genes and gene networks that are affected by repeated opioid administration remain understudied. We employed Next-Generation RNA-sequencing (RNA-seq) followed by quantitative chromatin immunoprecipitation to investigate changes in gene expression and their regulation in adult male and female rats’ dorsomedial ...
Tópico(s): Memory and Neural Mechanisms
2021 - Elsevier BV | Drug and Alcohol Dependence
Amanda Barks, Shirelle X. Liu, Michael Georgieff, Timothy C. Hallstrom, Phu V. Tran,
Iron deficiency (ID) anemia is the foremost micronutrient deficiency worldwide, affecting around 40% of pregnant women and young children. ID during the prenatal and early postnatal periods has a pronounced effect on neurodevelopment, resulting in long-term effects such as cognitive impairment and increased risk for neuropsychiatric disorders. Treatment of ID has been complicated as it does not always resolve the long-lasting neurodevelopmental deficits. In animal models, developmental ID results ...
Tópico(s): Genetics and Neurodevelopmental Disorders
2021 - Multidisciplinary Digital Publishing Institute | Nutrients
Shirelle X. Liu, Amanda Barks, Scott Lunos, Jonathan C. Gewirtz, Michael Georgieff, Phu V. Tran,
Early-life iron deficiency (ID) causes long-term neurocognitive impairments and gene dysregulation that can be partially mitigated by prenatal choline supplementation. The long-term gene dysregulation is hypothesized to underlie cognitive dysfunction. However, mechanisms by which iron and choline mediate long-term gene dysregulation remain unknown. In the present study, using a well-established rat model of fetal-neonatal ID, we demonstrated that ID downregulated hippocampal expression of the gene ...
Tópico(s): Genetics and Neurodevelopmental Disorders
2021 - Multidisciplinary Digital Publishing Institute | Nutrients
Shirelle Assaram, Nombulelo Magula, Suman Mewa Kinoo, Tivani P. Mashamba-Thompson,
It is estimated that 650,000 patients may develop human immunodeficiency virus (HIV)-related renal disease in South Africa. South Africa has recently adopted WHO policy, stipulating that all HIV-infected patients have access to antiretroviral treatment (ART) irrespective of CD4 cell count. We searched Google Scholar, PubMed, Medline, Cochrane Library, Worldcat.org and EBSCO host databases from July 2015 to December 2015. Eligibility criteria included articles pertaining to renal manifestations of ...
Tópico(s): HIV/AIDS Research and Interventions
2017 - BioMed Central | Systematic Reviews
Tanisha Shirelle Pruitt, Sharon Olanike Nicholas-Omoregbe, Jacqueline Bergdahl, Nicholas Nomoregbe, Victor Mbarika,
This study examined the effects of economic inequality on the academic achievement of the African-American males. African-American males are disproportionately poor, many living below the poverty line. The neighborhoods African-American males live in have few resources for learning which fosters low academic achievement. Predictions were made that African- American males in poor families will have lower academic achievement than white males and that African-American males who live in impoverished ...
Tópico(s): Youth Substance Use and School Attendance
2019 - Modestum Limited | Eurasia Journal of Mathematics Science and Technology Education
Walter H. Günzburg, Myo Myint Aung, Pauline Toa, Shirelle Ng, Eliot Read, Wee Jin Tan, Eva Maria Brandtner, John A. Dangerfield, Brian Salmons,
Abstract Background Gut microbiota in humans and animals play an important role in health, aiding in digestion, regulation of the immune system and protection against pathogens. Changes or imbalances in the gut microbiota (dysbiosis) have been linked to a variety of local and systemic diseases, and there is growing evidence that restoring the balance of the microbiota by delivery of probiotic microorganisms can improve health. However, orally delivered probiotic microorganisms must survive transit ...
Tópico(s): Probiotics and Fermented Foods
2020 - BioMed Central | Microbial Cell Factories
Benjamin P. C. Soo, Julian Tay, Shirelle Ng, Steven C. L. Ho, Yuansheng Yang, Sheng‐Hao Chao,
Tópico(s): RNA Interference and Gene Delivery
2017 - Springer Science+Business Media | Molecular Biotechnology
Marilyn E. Wende, Dana M. Alhasan, Shirelle H. Hallum, Ellen W. Stowe, Jan M. Eberth, Angela D. Liese, Charity B. Breneman, Alexander C. McLain, Andrew T. Kaczynski,
Local environments are increasingly the focus of health behavior research and practice to reduce gaps between fruit/vegetable intake, physical activity (PA), and related guidelines. This study examined the congruency between youth food and PA environments and differences by region, rurality, and income across the United States. Food and PA environment data were obtained for all U.S. counties (N = 3142) using publicly available, secondary sources. Relationships between the food and PA environment tertiles ...
Tópico(s): Physical Activity and Health
2021 - Elsevier BV | Preventive Medicine
Conference Abstract| February 01 2001 Understanding oestrogenicity: the way forward S. Barnes S. Barnes 1Department of Pharmacology and Toxicology, Birmingham, Alabama, USA Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (2001) 29 (1): A15. https://doi.org/10.1042/bst029a015b Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation S. Barnes; Understanding ...
Tópico(s): Steroid Chemistry and Biochemistry
2001 - Portland Press | Biochemical Society Transactions
Shirelle X. Liu, Daniela G Villacis Calderon, Zia L. Maxim, Montana M. Beeson, Raghavendra Rao, Phu V. Tran,
Abstract Neonatal encephalopathy (NE) impairs white matter development and results in long-term neurodevelopmental deficits. Leveraging prior findings of altered neuronal proteins carried by brain-derived extracellular vesicles (EVs) that are marked by a neural-specific cell surface glycoprotein Contactin-2 (CNTN2) in NE infants, the present study aimed to determine the correlation between brain and circulating CNTN2 + -EVs and whether NE alters circulating CNTN2 + -EV levels in mice. Brain tissue and plasma were ...
Tópico(s): Extracellular vesicles in disease
2024 - Elsevier BV | Neuroscience
Shirelle X. Liu, Andrew C. Harris, Jonathan C. Gewirtz,
Substance use disorder (SUD) represents a large and growing global health problem. Despite the strong addictive potency of drugs of abuse, only a minority of those exposed develop SUDs. While certain life experiences (e.g., childhood trauma) may increase subsequent vulnerability to SUDs, mechanisms underlying these effects are not yet well understood. Given the chronic and relapsing nature of SUDs, and the length of time that can elapse between prior life events and subsequent drug exposure, changes ...
Tópico(s): Genetics and Neurodevelopmental Disorders
2024 - Frontiers Media | Frontiers in Molecular Neuroscience
Shirelle X. Liu, Natalia Calixto Mancipe, Tate Gisslen, Michael Georgieff, Phu V. Tran,
Developmental iron deficiency (ID) is associated with long-term cognitive and affective behavioral impairments in humans. Preclinical studies have shown that developmental ID has short- and long-term effects on gene regulation. Prenatal choline supplementation partially rescues early-life ID-induced cognitive deficits in adult male rats.
Tópico(s): Trace Elements in Health
2024 - Elsevier BV | Journal of Nutrition
Shirelle H. Hallum, Marilyn E. Wende, Farnaz Shariati, Kelsey M. Thomas, Anna L. Chupak, Eleanor Witherspoon, Andrew T. Kaczynski,
Parks are critical components of healthy communities. This study explored neighborhood socioeconomic and racial/ethnic inequalities in park access and quality in a large U.S. southeastern metropolitan region. A total of 241 block groups were examined, including 77 parks. For each block group, we obtained multiple sociodemographic indicators, including unemployment rate, education level, renter-occupied housing, poverty rate, and racial/ethnic minority composition. All parks were mapped using geographical ...
Tópico(s): Noise Effects and Management
2024 - Multidisciplinary Digital Publishing Institute | International Journal of Environmental Research and Public Health
Shirelle Janine Naidoo, Thajasvarie Naicker,
Cytokines coordinate the intricate choreography of the immune system, directing cellular activities that mediate inflammation, pathogen defense, pathology and tissue repair. Within this spectrum, the anti-inflammatory prowess of interleukin-10 (IL-10) predominates in immune homeostasis. In normal pregnancy, the dynamic shift of IL-10 across trimesters maintains maternal immune tolerance ensuring fetal development and pregnancy success. Unravelling the dysregulation of IL-10 in pregnancy complications ...
Tópico(s): Pregnancy and Medication Impact
2024 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Marilyn E. Wende, Ellen W. Stowe, Shirelle H. Hallum, Jan M. Eberth, Angela D. Liese, Andrew T. Kaczynski,
This study investigated relationships between youth physical activity (PA) environments and income and non-Hispanic White population across the United States, stratified by US Census region and urban-rural designation. For all counties (n = 3142), publicly accessible data were used for sociodemographic indicators (ie, median household income and percent non-Hispanic White population) and a composite PA environment index (including exercise opportunities, violent crime incidence, walkability, and access ...
Tópico(s): Obesity, Physical Activity, Diet
2021 - Lippincott Williams & Wilkins | Journal of Public Health Management and Practice
Ellen W. Stowe, S. Morgan Hughey, Shirelle H. Hallum, Andrew T. Kaczynski,
Background: Attributes of the built environment, such as neighborhood walkability, have been linked to increased physical activity and reduced obesity risk. This relationship, however, has primarily been documented in adults; less is known about neighborhood walkability and youth obesity, as limited prior research has produced mixed findings. The purpose of this study was to examine the association between neighborhood walkability and youth obesity, including differences by urbanicity. Methods: ...
Tópico(s): Noise Effects and Management
2019 - Mary Ann Liebert, Inc. | Childhood Obesity
Shirelle H. Hallum, S. Morgan Hughey, Marilyn E. Wende, Ellen W. Stowe, Andrew T. Kaczynski,
Abstract Objective: This study examined the separate relationships between socio-economic disadvantage and the density of multiple types of food outlets, and relationships between socio-economic disadvantage and composite food environment indices. Design: Cross-sectional data were analysed using geospatial kernel density techniques. Food outlet data included convenience stores, discount stores, fast-food and fast casual restaurants, and grocery stores. Controlling for urbanicity and race/ethnicity, ...
Tópico(s): Health disparities and outcomes
2020 - Cambridge University Press | Public Health Nutrition
Erik Volz, Verity Hill, John T. McCrone, Anna Price, David Jorgensen, Áine O’Toole, Joel Southgate, Robert A. Johnson, Ben Jackson, Fabrícia F. Nascimento, Sara Rey, Samuel M. Nicholls, Rachel Colquhoun, Ana da Silva Filipe, James G. Shepherd, David J. Pascall, Rajiv Shah, Natasha Jesudason, Kathy Li, Ruth F. Jarrett, Nicole Pacchiarini, Matthew Bull, Lily Geidelberg, Igor Siveroni, Ian Goodfellow, Nicholas J. Loman, Oliver G. Pybus, David L. Robertson, Emma C. Thomson, Andrew Rambaut, Thomas R. Connor, Cherian Koshy, Emma L. Wise, Nick Cortes, Jessica Lynch, Stephen P. Kidd, Matilde Mori, Derek Fairley, Tanya Curran, James McKenna, Helen Adams, Christophe Fraser, Tanya Golubchik, David Bonsall, Catrin E. Moore, Sarah Caddy, Fahad Khokhar, Michelle Wantoch, Nicola Reynolds, Ben Warne, Joshua Maksimovic, Karla Spellman, Kathryn McCluggage, John P.T. Mo, Robert Beer, Safiah Afifi, Siân Morgan, Angela Marchbank, Anna Price, Christine Kitchen, Huw Gulliver, Ian Merrick, Joel Southgate, Martyn F. Guest, Robert J. Munn, Trudy Workman, Thomas R. Connor, William Fuller, Catherine Bresner, Luke B. Snell, Themoula Charalampous, Gaia Nebbia, Rahul Batra, Jonathan Edgeworth, Samuel C. Robson, Angela H. Beckett, Katie F. Loveson, David M. Aanensen, Anthony P. Underwood, Corin Yeats, Khalil Abudahab, Ben Taylor, Mirko Menegazzo, Gemma Clark, Darren Smith, Manjinder Khakh, Vicki M. Fleming, Michelle M. Lister, Hannah C. Howson‐Wells, Louise Berry, Tim Boswell, Amelia Joseph, Iona Willingham, Paul Bird, Thomas Helmer, Karlie Fallon, Christopher W. Holmes, Julian W. Tang, Veena Raviprakash, Stephen Campbell, Nicola Sheriff, Matthew Loose, Nadine Holmes, Christopher Moore, Matthew Carlile, Victoria Wright, Fei Sang, Johnny Debebe, Francesc Coll, Adrian W. Signell, Gilberto Betancor, Harry Wilson, Theresa Feltwell, Charlotte J. Houldcroft, Sahar Eldirdiri, Anita Kenyon, Thomas Davis, Oliver G. Pybus, Louis du Plessis, Alex E. Zarebski, Jayna Raghwani, Moritz U. G. Kraemer, Sarah François, Stephen W. Attwood, Tetyana I. Vasylyeva, M. Estée Török, William L. Hamilton, Ian Goodfellow, Grant Hall, Aminu S. Jahun, Yasmin Chaudhry, Myra Hosmillo, Malte L. Pinckert, Iliana Georgana, Anna Yakovleva, Luke W. Meredith, Samuel Moses, Hannah Lowe, Felicity Ryan, Chloe L. Fisher, Ali Raza Awan, John Boyes, Judith Breuer, Kathryn Harris, Julianne R. Brown, Divya Shah, Laura Atkinson, Jack C. D. Lee, Adela Alcolea-Medina, Nathan Moore, Nicholas Cortes, Rebecca Williams, Michael Chapman, Lisa J. Levett, Judith Heaney, Darren Smith, Matthew Bashton, Gregory R. Young, John N. Allan, Joshua P. Loh, Paul Randell, Alison Cox, Pinglawathee Madona, Alison Holmes, Frances Bolt, James Price, Siddharth Mookerjee, Aileen Rowan, Graham P. Taylor, Manon Ragonnet‐Cronin, Fabrícia F. Nascimento, David Jorgensen, Igor Siveroni, Rob Johnson, Olivia Boyd, Lily Geidelberg, Erik Volz, Kirstyn Brunker, Katherine Smollett, Nicholas J. Loman, Joshua Quick, Claire McMurray, Joanne Stockton, Sam Nicholls, Will Rowe, Radoslaw Poplawski, Rocío T. Martínez-Nuñez, Jenifer Mason, Trevor I. Robinson, Elaine O’Toole, Joanne Watts, Cassie Breen, Angela Cowell, Catherine Ludden, Graciela Sluga, Nicholas W. Machin, Shazaad S.Y. Ahmad, Ryan P. George, Fenella Halstead, Venkat Sivaprakasam, Emma C. Thomson, James G. Shepherd, Patawee Asamaphan, Marc Niebel, Kathy Li, Rajiv Shah, Natasha Jesudason, Yasmin A. Parr, L. Tong, Alice Broos, Daniel Mair, Jenna Nichols, Stephen Carmichael, Kyriaki Nomikou, Elihú Aranday-Cortés, Natasha Johnson, Igor Starinskij, Ana da Silva Filipe, David L. Robertson, Richard Orton, Joseph Hughes, Vattipally B. Sreenu, Joshua B. Singer, Antony Hale, Louissa Macfarlane-Smith, Katherine L. Harper, Yusri Taha, Brendan Payne, Shirelle Burton-Fanning, Sheila Waugh, Jennifer Collins, Gary Eltringham, Kate Templeton, M. McHugh, Rebecca Dewar, Elizabeth Wastenge, Samir Dervisevic, Rachael Stanley, Reenesh Prakash, Claire Stuart, Ngozi Elumogo, Dheeraj Sethi, Emma Meader, Lindsay Coupland, Will Potter, Clive Graham, Edward Barton, Debra Padgett, Garren Scott, Emma Swindells, Jane Greenaway, Andrew Nelson, Wen C. Yew, Paola C. Resende Silva, Monique Andersson, R. H. Shaw, Tim Peto, Anita Justice, David W. Eyre, Derrick Crooke, Sarah Hoosdally, Tim J. Sloan, Nichola Duckworth, Sarah Walsh, Anoop Chauhan, Sharon Glaysher, Kelly Bicknell, Sarah Wyllie, Ethan Butcher, Scott Elliott, Allyson Lloyd, Robert Impey, Nick Levene, Lynn Monaghan, Declan Bradley, Elias Allara, Clare Pearson, Peter Muir, Ian B. Vipond, Richard Hopes, Hannah M. Pymont, Stephanie Hutchings, Martin D. Curran, Surendra Parmar, Angie Lackenby, Tamyo Mbisa, Steven G. Platt, Shahjahan Miah, David Bibby, Carmen de Guerrero Manso, Jonathan Hubb, Meera Chand, Gavin Dabrera, Mary Ramsay, Daniel Bradshaw, Alicia Thornton,
Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic ...
Cell Press
Su Han Lum, Sabeena Selvarajah, Àngela Deyà‐Martínez, Peter McNaughton, Ali Sobh, Sheila Waugh, Shirelle Burton-Fanning, Lisa Newton, Julie Gandy, Zohreh Nademi, Stephen Owens, Eleri Williams, Marieke Emonts, Terry Flood, Andrew J. Cant, Mario Abinun, Sophie Hambleton, Andrew R. Gennery, Mary Slatter,
BackgroundPost hematopoietic cell transplantation (HCT) autoimmune cytopenia (AIC) is a potentially life-threatening complication, but studies focusing on large cohorts of patients transplanted for primary immunodeficiency are lacking.ObjectivesThis study sought to determine the incidence, risk factors, and outcomes of post-HCT AIC and B-lymphocyte function following rituximab.MethodsWe retrospectively studied 502 children with primary immunodeficiency who were transplanted at our center between 1987 ...
Tópico(s): Blood disorders and treatments
2020 - Elsevier BV | Journal of Allergy and Clinical Immunology
Bo Meng, Steven A. Kemp, Guido Papa, Rawlings Datir, Isabella A. T. M. Ferreira, Sara Marelli, William T. Harvey, Spyros Lytras, Ahmed Mohamed, Giulia Gallo, Nazia Thakur, Dami A. Collier, Petra Mlčochová, Samuel C. Robson, Nicholas J. Loman, Thomas R. Connor, Tanya Golubchik, Rocio T. Martinez Nunez, Catherine Ludden, Sally Corden, Ian Johnston, David Bonsall, Colin P. Smith, Ali Raza Awan, Giselda Bucca, M. Estée Török, Kordo Saeed, Jacqui Prieto, David K. Jackson, William L. Hamilton, Luke B. Snell, Catherine Moore, Ewan M. Harrison, Sónia Gonçalves, Derek Fairley, Matthew Loose, Joanne Watkins, Rich Livett, Samuel Moses, Roberto Amato, Samuel M. Nicholls, Matthew Bull, Darren Smith, Jeff Barrett, David M. Aanensen, Martin D. Curran, Surendra Parmar, Dinesh Aggarwal, James G. Shepherd, Matthew D. Parker, Sharon Glaysher, Matthew Bashton, Anthony P. Underwood, Nicole Pacchiarini, Katie F. Loveson, Kate Templeton, Cordelia F. Langford, John Sillitoe, Thushan I. de Silva, Dennis Wang, Dominic Kwiatkowski, Andrew Rambaut, Justin O’Grady, Simon Cottrell, Matthew T. G. Holden, Emma C. Thomson, Husam Osman, Monique Andersson, Anoop Chauhan, Mohammed O. Hassan-Ibrahim, Mara Lawniczak, Alex Alderton, Meera Chand, Chrystala Constantinidou, Meera Unnikrishnan, Alistair C. Darby, Julian A. Hiscox, Steve Paterson, Inigo Martincorena, Erik Volz, Andrew J. Page, Oliver G. Pybus, Andrew R. Bassett, Cristina V. Ariani, Michael H. Spencer Chapman, Kathy K. Li, Rajiv Shah, Natasha Jesudason, Yusri Taha, M. McHugh, Rebecca Dewar, Aminu S. Jahun, Claire McMurray, Sarojini Pandey, James McKenna, Andrew Nelson, Gregory R. Young, Clare M. McCann, Scott Elliott, Hannah Lowe, Ben Temperton, Sunando Roy, Anna Price, Sara Rey, Matthew Wyles, Stefan Rooke, Sharif Shaaban, Mariateresa de Cesare, Laura Letchford, Siona Silveira, Emanuela Pelosi, Eleri Wilson-Davies, Myra Hosmillo, Áine O’Toole, Andrew R. Hesketh, Richard Stark, Louis du Plessis, Chris Ruis, Helen Adams, Yann Bourgeois, Stephen L. Michell, Dimitris K. Grammatopoulos, Jonathan D. Edgeworth, Judith Breuer, John A. Todd, Christophe Fraser, David Buck, John P.T. Mo, Gemma L. Kay, Steve Palmer, Sharon J. Peacock, David Heyburn, Danni Weldon, Esther Robinson, Alan McNally, Peter Muir, Ian B. Vipond, John Boyes, Venkat Sivaprakasam, Tranprit Salluja, Samir Dervisevic, Emma Meader, Naomi R. Park, Karen Oliver, Aaron R. Jeffries, Sascha Ott, Ana da Silva Filipe, David Simpson, Chris Williams, Jane Masoli, Bridget Knight, Christopher R. Jones, Cherian Koshy, Amy Ash, Anna Casey, Andrew Bosworth, Liz Ratcliffe, Li Xu-McCrae, Hannah M. Pymont, Stephanie Hutchings, Lisa Berry, Katie Jones, Fenella Halstead, Thomas P. Davis, Christopher W. Holmes, Miren Iturriza-Gomara, Anita O. Lucaci, Paul Randell, Alison Cox, Pinglawathee Madona, Kathryn Harris, Julianne R. Brown, Tabitha Mahungu, Dianne Irish-Tavares, Tanzina Haque, Jennifer Hart, Eric Witele, Melisa Fenton, Steven Liggett, Clive Graham, Emma Swindells, Jennifer Collins, Gary Eltringham, Stephen Campbell, C. Patrick McClure, Gemma Clark, Tim J. Sloan, C. Wayne Jones, Jessica Lynch, Ben Warne, Steven N. Leonard, Jillian Durham, Thomas Williams, Sam Haldenby, Nathaniel Storey, Nabil-Fareed Alikhan, Nadine Holmes, Christopher Moore, Matthew Carlile, Malorie Perry, Noel Craine, Ronan A Lyons, Angela H. Beckett, Salman Goudarzi, Christopher Fearn, Kate F. Cook, Hannah Dent, Hannah Paul, Robert M. Davies, Beth Blane, Sophia T. Girgis, Mathew A. Beale, Katherine L. Bellis, Matthew J. Dorman, Eleanor Drury, Leanne Kane, Sally Kay, Samantha McGuigan, Andrew Nelson, Liam Prestwood, Shavanthi Rajatileka, Rahul Batra, Rachel Williams, Mark Kristiansen, Angie Green, Anita Justice, Adhyana I. K. Mahanama, Buddhini Samaraweera, Nazreen F. Hadjirin, Joshua Quick, Radoslaw Poplawski, Leanne M. Kermack, Nicola Reynolds, Grant Hall, Yasmin Chaudhry, Malte L. Pinckert, Iliana Georgana, Robin J. Moll, Alicia Thornton, Richard Myers, Joanne Stockton, Charlotte A. Williams, Wen C. Yew, Alexander J. Trotter, Amy Trebes, George MacIntyre-Cockett, Alec Birchley, Alexander Adams, Amy Plimmer, Bree Gatica-Wilcox, Caoimhe McKerr, Ember Hilvers, Hannah Jones, Hibo Asad, Jason Coombes, Johnathan M. Evans, Laia Fina, Lauren Gilbert, Lee Graham, Michelle Cronin, Sara Kumziene-Summerhayes, Sarah Taylor, Sophie Jones, Danielle C. Groves, Peijun Zhang, Marta Gallis, Stavroula F. Louka, Igor Starinskij, Christopher Jackson, Marina Gourtovaia, Gerry Tonkin‐Hill, Kevin Lewis, Jaime M. Tovar-Corona, Keith James, Laura Baxter, Mohammad Tauqeer Alam, Richard Orton, Joseph Hughes, Vattipally B. Sreenu, Manon Ragonnet‐Cronin, Fabrícia F. Nascimento, David Jorgensen, Olivia Boyd, Lily Geidelberg, Alex E. Zarebski, Jayna Raghwani, Moritz U. G. Kraemer, Joel Southgate, Benjamin B. Lindsey, Timothy M. Freeman, Jon-Paul Keatley, Joshua B. Singer, Leonardo de Oliveira Martins, Corin Yeats, Khalil Abudahab, Ben Taylor,
We report severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike ΔH69/V70 in multiple independent lineages, often occurring after acquisition of receptor binding motif replacements such as N439K and Y453F, known to increase binding affinity to the ACE2 receptor and confer antibody escape. In vitro, we show that, although ΔH69/V70 itself is not an antibody evasion mechanism, it increases infectivity associated with enhanced incorporation of cleaved spike into virions. ΔH69/V70 is able ...
Cell Press