Dmitrij Hristodorov, Manal Amoury, Radoslav Mladenov, Judith Niesen, Katharina Arens, Nina Berges, Lea Hein, Stefano Fiore, Anh‐Tuan Pham, Michael Hühn, Wijnand Helfrich, Rainer Fischer, Theo Thepen, Stefan Barth,
In normal epithelia, the epithelial cell adhesion molecule (EpCAM) expression is relatively low and only present at the basolateral cell surface. In contrast, EpCAM is aberrantly overexpressed in various human carcinomas. Therefore, EpCAM is considered to be a highly promising target for antibody-based cancer immunotherapy. Here, we present a new and fully human cytolytic fusion protein (CFP), designated "anti-EpCAM(scFv)-MAP," that is comprised of an EpCAM-specific antibody fragment (scFv) genetically ...
Tópico(s): CAR-T cell therapy research
2014 - American Association for Cancer Research | Molecular Cancer Therapeutics
Bram ten Cate, Douwe F. Samplonius, Theo Bijma, L.F.M.H. de Leij, Wijnand Helfrich, Edwin Bremer,
Tópico(s): Multiple Myeloma Research and Treatments
2006 - Springer Nature | Leukemia
Edwin Bremer, Marco de Bruyn, Douwe F. Samplonius, Theo Bijma, Bram ten Cate, Lou F. M. H. de Leij, Wijnand Helfrich,
Previously, we have shown that epidermal growth factor receptor (EGFR)-selective delivery of soluble tumor necrosis factor-related apoptosis-inducing ligand (sTRAIL), by genetic fusion to antibody fragment scFv425, enhances the tumor-selective pro-apoptotic activity of sTRAIL. Insight into the respective contribution of the agonistic receptors TRAIL-R1 and TRAIL-R2 to TRAIL-induced apoptosis may provide a rational approach to further optimize TRAIL-based therapy. Recently, this issue has been investigated ...
Tópico(s): NF-κB Signaling Pathways
2008 - Springer Science+Business Media | Journal of Molecular Medicine
Bram ten Cate, Edwin Bremer, Marco de Bruyn, Theo Bijma, Douwe F. Samplonius, Michael Schwemmlein, Gerwin Huls, G H Fey, Wijnand Helfrich,
Gemtuzumab ozogamicin (GO, Mylotarg) is a targeted therapeutic agent in which an anti-CD33 antibody is chemically coupled to a highly cytotoxic calicheamicin derivative through a hydrolysable linker. GO has improved the treatment outcome for a subgroup of acute myeloid leukemia (AML) patients, but its use is associated with severe myelosuppression and hepatotoxicity. Here, we report on a novel anti-leukemia agent, designated scFvCD33:sTRAIL, in which an anti-CD33 single chain fragment of variable ...
Tópico(s): Acute Myeloid Leukemia Research
2009 - Springer Nature | Leukemia
Obbina Abani, Amr E. Abbas, Fatima Abbas, Jonathan R. Abbas, Kaja Abbas, Mustafa Abbas, Sadia Abbasi, H Abbass, Anne L. Abbott, Nadine Abdallah, Ashraf Omar Abdelaziz, M Abdelfattah, Bushra Abdelqader, A Abdul, Basir Abdul, Sami Aftab Abdul, Abdul Rasheed, Abdulakeem Ajibode, Rezan A. Kadir, Abdullah Mohammed, Abdulfatahi Abdulmumeen, Rasheed Abdul-Raheem, Niyaz Abdulshukkoor, Kula Abdusamad, Yazeed Abed El Khaleq, Mai Abedalla, Abeer Abeer Ul Amna, Laurent Abel, Kathy Abernethy, Movin Abeywickrema, Chandra Abhinaya, Ahmad Farid Abidin, Adebanke Aboaba, Abigail Aboagye-Odei, Christopher Aboah, Heba Aboelela, H Abo-Leyah, Karim Abouelela, Ahmed Abou-Haggar, Mahmoud Abouibrahim, Ahmed Abousamra, M. Abouzaid, Mathew Abraham, Tizzy Abraham, A. Abraheem, J. Abrams, Richard Abrams, H.J. Abu, Ahmad Abu-Arafeh, S.M. Abubacker, Akata Abung, Yousef Abusamra, Yaa Aceampong, Amaka Achara, Devikumar Acharya, Faustina Acheampong, Paul Acheampong, Sarah Acheampong, James Acheson, Shiella Achieng, Andrés Acosta, Rebecca Acquah, Cindy Acton, Jacqueline Adabie-Ankrah, Pauline Adair, AS Adam, Fiona Adam, Matthew Adam, Huzaifa Adamali, M Adamczyk, Christopher Adams, David H. Adams, Katie Adams, Lisa C. Adams, Nicholas M. Adams, Richard Adams, Tempestt Adams, Laura Adamu-Ikeme, Krishma Adatia, Kim G. Adcock, Lawrence Addai-Boampong, A. Addo, Oluwafemi Adeagbo, Adewole Adebiyi, O. S. Adedeji, Yewande Adegeye, K Adegoke, Vicki Adell, Sherna Adenwalla, F.W. Adeoye, O.A. Adesemoye, E.O. Adewunmi, A Adeyanju, Joyce Adeyemi, Titilope A. Adeyemo, Bidur Adhikari, SA Adhikari, R Adhikary, A. Aditya, Patience Adjepong, Gabrielle Adkins, Ahmad Adnan, M Adriaanse, J. Aeron-Thomas, Debbie Affleck, Carmel Afnan, Muhammad Abdur Rahman Afridi, Patricia Afrim, FA Afriyie, Z.A. Aftab, Agnes Awuah, Mudit Agarwal, P.N. Agasiya, Rachel Agbeko, C Agbo, Sunil Aggarwal, A. Aghababaie, L A Aguilar Jimenez, J.A. Agyekum, Kwame Agyen, E.K. Ahadome, S Ahamed Sadiq, MH Ahammed Nazeer, Ahmad Mukhtar, Saad Ahmad, A. Ahmed, BAR Ahmed, Bilal Ahmed, Farhan Ahmed, Helal Uddin Ahmed, Irshad Ahmed, Kawsar Ahmed, L Ahmed, Muhammad S. Ahmed, MC Ahmed, MS Ahmed, Nausheen Ahmed, Nausheen Ahmed, Osama Ahmed, Ahmed Ra, Rizwan Ahmed, Rizwan Ahmed, Sanam Ahmed, SG Ahmed, SH Ahmed, Rabeka A. Ali, Bilal A Mohamud, Sanam Ahmed, Sana Ahmer, Augustine Ahonia, Clement Aidoo, C Aiken, Dhiraj Ail, Mark Ainsworth, Myriam Aissa, L. Aitken, B. Ajay, Abdulakeem Ajibode, Ahdi Noomen Ajmi, Nahid Akhtar, Suha Akili, Bolutito Akinbiyi, O Akindolie, Yinka Akinfenwa, Olugbenga Akinkugbe, Ibrahim Akinpelu, Muhammad Akram, Olugbenro Aktinade, Uzayr Akudi, ASAR Al Aaraj, Ali Al Balushi, Majd Al Dakhola, Aladdin Al Swaifi, Eslam Al‐Abadi, A Alabi, Narendra Aladangady, Mahmoud Alafifi, AHM Khurshid Alam, Md. Samrat Alam, A Al-Asadi, Kyriaki S. Alatzoglou, Paul Albert, A. Albertus, Lorraine Albon, Antonio Luna, Gemma Alcorn, Stephen Alcorn, Andrés Gómez-Aldana, David Alderdice, Abdullah Aldesouki, Rayan Aldouri, Jonathan Aldridge, N. Aldridge, R. H. Good Ale, Ana Alegria, Amit Alexander, Craig J. Alexander, John H. Alexander, PDG Alexander, Julyan Al-Fori, Laith Alghazawi, Osama Alhabsha, Bahij Al-Hakim, R Alhameed, M Al-Hayali, Shams Al‐Hity, Ala Ali, FR Ali, Johar Ali, Mohammad Ali, MS Ali, Nayab Ali, Omar Hasan Ali, R Ali, Syed Ahsan Ali, Emilio Aliberti, J Alin, Abid Alina, Analyn Alipustain, Bachti Alisjahbana, Fine Aliyuda, Kaveh Alizadeh, Maithem Al-Jibury, Saja Al-Juboori, Mohammad Ali, A. Alkhudhayri, Moutaz Alkhusheh, Frank N. Allan, Nicholas P. Allan, Alison Allanson, Robert Allcock, Emma Allen, Jason W. Allen, Keeley Allen, Louise Allen, Pamela B. Allen, R J Allen, Stephen Allen, Tammy D. Allen, Abiola Alli, Kelly C. Allison, Brent E. Allman, H.K. Allsop, Lynne Allsop, David Allsup, A.F.T. Almahroos, Hassan Al-Moasseb, M. Al-Obaidi, Lina Alomari, Akram Al-Rabahi, Bahar Al-Ramadhani, Z. Al-Saadi, Riyam Al-Sammarraie, Inji Alshaer, Rustam Al‐Shahi Salman, Warkaq Al-Shamkhani, F Alsheikh, Bashar Al‐Sheklly, Sana Altaf, A Alty, Míriam J. Álvarez, Maria Alvarez Corral, Edward Alveyn, Maysaa Alzetani, Susan Amamou, N Amar, S Ambalavanan, Robert Ambrogetti, Christopher S. Ambrose, A Ameen, Amel Amelia Ganefianty, Katharine Ames, M. R. Amezaga, A. Amin, A. Amin, Kawa Amin, S Amin, Tarek Tawfik Amin, B Amit, Awais Amjad, Nasser Mohammad Amjad, James Amoah-Dankwa, Amos Amoako-Adusei, Victoria Amosun, Mochammad Fariz Amsal, Khaled Amsha, John Amuasi, Noelia Martín, Pugh Amy, Ann Anada, Atul Anand, Samantha Anandappa, S.D. Anantapatnaikuni, N.K.N. Andari, Élizabeth Anderson, Jennifer Anderson,
BackgroundEmpagliflozin has been proposed as a treatment for COVID-19 on the basis of its anti-inflammatory, metabolic, and haemodynamic effects. The RECOVERY trial aimed to assess its safety and efficacy in patients admitted to hospital with COVID-19.MethodsIn the randomised, controlled, open-label RECOVERY trial, several possible treatments are compared with usual care in patients hospitalised with COVID-19. In this analysis, we assess eligible and consenting adults who were randomly allocated ...
Elsevier BV
Saul N. Faust, Richard Haynes, Christine E. Jones, Natalie Staplin, Elizabeth Whittaker, Thomas Jaki, Ed Juszczak, Enti Spata, Mandy Wan, Alasdair Bamford, Paul Dimitri, Adam Finn, John Furness, Athimalaipet V Ramanan, Chris Gale, Katrina Cathie, Simon B. Drysdale, Jolanta Bernatoniene, Clare Murray, Charles Christoph Roehr, Paul Fleming, Andrew Riordan, Srini Bandi, Deepthi Jyothish, Jennifer Evans, Marieke Emonts, Dominic F. Kelly, Nazima Pathan, Patrick Davies, Rosie Hague, Louisa Pollock, Malcolm G. Semple, Leon Peto, J. Kenneth Baillie, Maya H Buch, Katie Jeffery, Marian Knight, Wei Shen Lim, Alan Montgomery, Aparna Mukherjee, Andrew Mumford, Kathy Rowan, Guy Thwaites, Marion Mafham, Jonathan Emberson, Martin Landray, Peter Horby, Lucy C. Chappell, Jeremy Day, DV Dung, Jeremy Day, NN Quang, Prof Binh, Erlina Burhan, Bachti Alisjahbana, Janak Koirala, S Basnet, Evelyne Kestelyn, Buddha Basnyat, Pradip Gyanwali, RL Hamers, Peter Sandercock, Janet Darbyshire, David L. DeMets, Robert Fowler, David G. Lalloo, Mohammed Munavvar, Ian Roberts, Adilia Warris, Janet Wittes, A Craddock-Bamford, Janet Barton, Ahmet Başoğlu, Rosemary Brown, Wojciech Brudlo, Emmanuelle Denis, Lucy Fletcher, Sarah Howard, Sabrina Musini, K. Taylor, Guanglin Cui, Bob Goodenough, Andy J. King, M Lay, David R. Murray, W. Grant Stevens, Karl Wallendszus, Robert C. Welsh, Charles Crichton, Jane C. Davies, Raph Goldacre, Charlie Harper, F Knight, Miles A. Nunn, Hizni Salih, John J. Welch, Mark Campbell, Guilherme Pessoa-Amorim, Mohamed A. Zayed, Jonathan D. Wiles, GRANT P. BAGLEY, Scott J. Cameron, Sarah Chamberlain, Barbara Farrell, Hannah Freeman, Ann R. Kennedy, Anne Whitehouse, Sara Wilkinson, Caroline Wood, Christina Reith, K Davies, Heather Halls, Lisa Holland, Robert Truell, Kevin C. Wilson, Emma Lingwood, L. Howie, Michael P. Lunn, Penelope Rodgers, John Amuasi, Kathleen Baird, Ting Bao, Buddha Basnyat, Mustapha Bittaye, Joseph Bonney, Umberto D’Alessandro, Meghnath Dhimal, Pradip Gyanwali, RL Hamers, T Huyen, Abubacarr Jagne, Abhilasha Karkey, Evelyne Kestelyn, Oumou Maïga, E Matey, Behzad Nadjm, Jeremy Nel, Suman Pant, Khairunnisa Puspatriani, Mutia Rahardjani, S Raijal, Helen Rees, Atika Rimainar, Charles W.M. Roberts, Anna Rocca, Sailendra Kumar Duwal Shrestha, Effua Usuf, C. Vidaillic, Fitria Wulandari, Amit Alexander, M. R. Amezaga, Charlotte Armah, Asma Asghar, Paula Aubrey, Kerry Barker-Williams, Amanda Barnard, John R. Bartholomew, Dawn Beaumont-Jewell, Simon Beddows, J. Beety, Chris Birch, Peter Boyle, Morwenna Brend, Matthew Brookes, Claire Callens, Danielle Campbell, Helen Campbell, Hugo Ten Cate, Emma S. Chambers, K Chapman, Antoinette B. Coe, Joanne Collins, Sarah Crawshaw, Sandeep R. Das, Anthony De Soyza, Erika Denton, Pamela Dicks, Mary Dolman, Kate Donaldson, Lucy Dowden, Shawn Dowling, Charles G. Drake, Hayley Duckles-Leech, Helen Duffy, Lee Gerdes, Kristen Gibbons, Lorena Almeida Gill, Kimberly Gilmour, Joanne Goodwin, James E. Graham, Christopher Green, Claire Hall, Alistair S. Hall, Kate Hampshire, Jane Hanson, T Harman, Helen Harper, Susan T.L. Harrison, James W. Hicks, Helen Hodgson, Michael Hough, Susan Jackson, Graham Johnson, Jodie Kirk, Nicholas R. Lemoine, Chris Levett, S Lock, Teresa Lockett, M Logan, Kaatje Lomme, Jing‐chao Luo, Nigel A.J. McMillan, Helen Membrey, Nhlanhla Mguni, Jane Minton, H Monaghan, Shawn N. Murphy, Natasha Muzengi, Madiha Naz, Ian Nickson, Miranda Odam, Udeme Ohia, Eleanor OKell, Antonio Oliver, Karen Pearson, Kirsty Pine, Richard J. Pleass, David A. Porter, Linda Porter, Alison Potter, Vanessa Poustie, Steven Pratt, Anna Price, Alicia Priest, Anthony Rodgers, C. Rook, Pablo Ryan, S Sam, Phoebe Sharratt, James K. Sheffield, Justine Shenton, Karen Shirley, Timothy Skinner, Herbert B. Slade, Mihaela Sutu, Judy Taylor, E Thomas, Heather Tinkler, Alison Unsworth, R. Usher, William van’t Hoff, S E Walker, James Walters, E. Walton, Jenny Warmington, Emma Wayman, Patricia Williams, John Williamson, Deborah A. Williamson, Fiona Yelnoorkar, Marian Knight, Kenneth Hodson, Sue Pavord, Catherine Williamson, Louise Bowman, Fei Chen, Robert W. Clarke, Michelle Goonasekara, William G. Herrington, P. G. Judge, S Ng, David Preiss, Christina Reith, Emily Sammons, Dandan Zhu, C Arkley, Paul Bowker, Johanna Bruce, Victoria Byrne-Watts, G Chapman, Grahame J. Coleman, Tom Denwood, J.D. Gray, David A Harrison, Nancy Mather, Heather Pinches, A.R. Rees, Stephanie Rees, Gail Turner, Obbina Abani, Amr E. Abbas, Fatima Abbas, Jonathan R. Abbas, Kaja Abbas, Mustafa Abbas, Sadia Abbasi,
BackgroundPaediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS), also known as multisystem inflammatory syndrome in children (MIS-C) emerged in April, 2020. The paediatric comparisons within the RECOVERY trial aimed to assess the effect of intravenous immunoglobulin or corticosteroids compared with usual care on duration of hospital stay for children with PIMS-TS and to compare tocilizumab (anti-IL-6 receptor monoclonal antibody) or anakinra (anti-IL-1 receptor ...
Elsevier BV
Bram ten Cate, Edwin Bremer, Douwe F. Samplonius, Theo Bijma, Michael Schwemmlein, G H Fey, Wijnand Helfrich,
Tópico(s): Virus-based gene therapy research
2008 - Elsevier BV | Annals of Oncology
... Hebert John Heckenlively Stephan Heckers Franz Hefti Charlotte Helfrich-Förster Alfred Heller Hugh C. Hemmings Anita E. ... Swidbert Ott Ole Peter Ottersen Charles C. Ouimet Theo D. Palmer Deepak N. Pandya W. Michael Panneton ...
Tópico(s): Neurology and Historical Studies
2004 - Wiley | The Journal of Comparative Neurology
... B. Hedwig Ralf Heinrich William J Heitler Charlotte Helfrich-Förster Stefan Heller Christopher Henderson Craig K. Henkel ... Osumi Mary Ann Ottinger Miklós Palkovits Alan Palmer Theo Palmer S. Panda Michael Pankratz Pertti Panula David ... Valentino Johannes van der Want Stephen Van Hooser Theo Van veen Veronique VanderHorst *David Vaney Alexander Varshavsky ...
Tópico(s): Neurology and Historical Studies
2010 - Wiley | The Journal of Comparative Neurology
... Hawryshyn Anders Hay-Schmidt R. David Heathcote Charlotte Helfrich-Förster Anita Hendrickson Craig K. Henkel Allan Herbison ... Jose M. Palacios Leo Pallanck Sarah L. Pallas Theo D. Palmer Harish Pant Nancy Papalopulu Luis F. ...
Tópico(s): Genetics, Bioinformatics, and Biomedical Research
2005 - Wiley | The Journal of Comparative Neurology