Niklas Benedikt Pepper, Hans Theodor Eich, Michael Müther, Michael Oertel, Stephan Rehn, Dorothee Cäcilia Spille, Walter Stummer,
Abstract Background Despite improvements in surgical as well as adjuvant therapies over the last decades, the prognosis for patients with glioblastoma remains poor. Five-Aminolevulinic acid (5-ALA) induced porphyrins are already used for fluorescence-guided resection and as photosensitizer for photodynamic therapy. New findings reveal their potential use as sensitizing agents in combination with ionizing radiation. Methods We initiated a phase I/II dose escalation study, treating patients with recurrence ...
Tópico(s): Photodynamic Therapy Research Studies
2024 - BioMed Central | Radiation Oncology
Tópico(s): Historical Legal Studies and Society
1870 - De Gruyter | Zeitschrift der Savigny-Stiftung für Rechtsgeschichte Germanistische Abteilung
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Tópico(s): Classical Studies and Legal History
1869 - De Gruyter | Zeitschrift der Savigny-Stiftung für Rechtsgeschichte Germanistische Abteilung
Tópico(s): Law and Political Science
1867 - De Gruyter | Zeitschrift der Savigny-Stiftung für Rechtsgeschichte Germanistische Abteilung
Gewöhnlich wird angenommen, daß die Konstitutionengesetzgebung des Kurfürsten August von Sachsen vom Jahr 1572 in erste Anregung gebracht worden sei durch die Kursächsischen Stände, welche im Jahr 1565 unter anderem auch das "Bedenken" vorbrachten : "Es werden in den Schöppenstühlen in Ew
Tópico(s): Historical Influence and Diplomacy
1864 - De Gruyter | Zeitschrift der Savigny-Stiftung für Rechtsgeschichte Germanistische Abteilung
Tópico(s): Law and Political Science
1864 - De Gruyter | Zeitschrift der Savigny-Stiftung für Rechtsgeschichte Germanistische Abteilung
Niklas Benedikt Pepper, Nicholas Grischa Prange, Fabian M. Troschel, Kai Kroeger, Michael Oertel, Tanja Kuhlmann, Michael Müther, Oliver Grauer, Walter Stummer, Hans Theodor Eich,
Glioblastoma is the most common malignant brain tumor in adults. Even after maximal safe resection and adjuvant chemoradiotherapy, patients normally relapse after a few years or even months. Standard treatment for recurrent glioblastoma is not yet defined, with re-resection, re-irradiation, and systemic therapy playing key roles. Usually, re-irradiation is combined with concurrent chemotherapy, harnessing the radiosensitizing effects of alkylating agents.
Tópico(s): Ocular Oncology and Treatments
2024 - Multidisciplinary Digital Publishing Institute | Cancers
Niklas Benedikt Pepper, David Rene Steike, Heidi Yppärilä-Wolters, Michael Müther, Dorothee Wiewrodt, Hendrik Berssenbrügge, Oliver Grauer, Philipp Lenz, Walter Stummer, Hans Theodor Eich,
Abstract Purpose While glioblastoma is the most common malignant brain tumor in adults, extracerebral manifestations are very rare in this highly aggressive disease with poor prognosis. Methods We conducted a systematic literature review in the PubMed database and complemented the data by inclusion of a case treated in our clinic. In this context, we report on a 60-year-old woman with a right frontal glioblastoma, IDH wildtype, MGMT methylated. Results Six months after initial diagnosis and primary ...
Tópico(s): Meningioma and schwannoma management
2025 - Springer Science+Business Media | Strahlentherapie und Onkologie