Yu Yao, Jens Vent‐Schmidt, Matthew D. McGeough, May Q. Wong, Hal M. Hoffman, Theodore S. Steiner, Megan K. Levings,
The two best-characterized types of CD4(+) regulatory T cells (Tregs) are Foxp3(+) Tregs and Foxp3(-) type 1 regulatory (Tr1) cells. The ability of Foxp3(+) Tregs and Tr1 cells to suppress adaptive immune responses is well known, but how these cells regulate innate immunity is less defined. We discovered that CD44(hi)Foxp3(-) T cells from unmanipulated mice are enriched in Tr1 cell precursors, enabling differentiation of cells that express IL-10, as well as Tr1-associated cell surface markers, CD49b ...
Tópico(s): IL-33, ST2, and ILC Pathways
2015 - American Association of Immunologists | The Journal of Immunology
Laura Cook, Martin Ståhl, Xiao Han, Aisha Nazli, Katherine N. MacDonald, May Q. Wong, Kevin Tsai, Sara Dizzell, Kevan Jacobson, Brian Bressler, Charu Kaushic, Bruce A. Vallance, Theodore S. Steiner, Megan K. Levings,
... levels of effector cytokines, and type 1 Treg (Tr1) cells, which are FOXP3-negative and secrete interleukin ( ... 10. IL10 is an anti-inflammatory cytokine, so Tr1 cells might be used in the treatment of ... to develop methods to isolate and expand human Tr1 cells and define their functions.MethodsWe obtained blood ... with anti-CD3 and anti-CD28 beads, and Tr1 cells were purified by using an IL10 cytokine- ... sorted as CD4+CD25highCD127low cells from unstimulated cells. Tr1 and FOXP3-positive Treg cells were expanded, and ...
Tópico(s): Immunotherapy and Immune Responses
2019 - Elsevier BV | Gastroenterology
Daniel J. Lisko, S Menzies, Laura M. Sly, Theodore S. Steiner,
Abstract Background Crohn’s disease (CD), a form of inflammatory bowel disease (IBD), is characterized by chronic inflammation that can occur anywhere along the gastrointestinal (GI) tract, but commonly involves the distal portion of the ileum. Src homology 2 (SH2) domain-containing inositol polyphosphate 5-phosphatase 1 (SHIP) is a hematopoietic-specific regulator of secondary signals generated by the PI3K pathway and regulates immune activation. SHIP-/- mice, at 6–8 weeks of age, spontaneously develop ...
Tópico(s): Inflammatory Bowel Disease
2020 - Oxford University Press | Journal of the Canadian Association of Gastroenterology
Chad Poloni, A Sze, S Lim, Mohammad Hossein Esmaeilzadeh, X Wang, Laura Cook, Theodore S. Steiner,
Tópico(s): IL-33, ST2, and ILC Pathways
2025 - Oxford University Press | Journal of the Canadian Association of Gastroenterology
Chad Poloni, A Sze, X Wang, S Lim, Theodore S. Steiner,
... We have previously shown type 1 regulatory cells (Tr1s) are capable of suppressing inflammatory macrophages, promote barrier ... of mucin-producing goblet cells. We hypothesize that Tr1 cells can prevent inflammatory damage and fibrosis in ... of acute gut damage. Purpose We hypothesize that Tr1 cells can prevent inflammatory damage and fibrosis in ... damage. Here we evalute the therapeutic potential of Tr1 cells in an model of acute intestinal epithelial damage. Method Tr1 cells were isolated and expanded from CD4+ CD44high ...
Tópico(s): Gastrointestinal motility and disorders
2023 - Oxford University Press | Journal of the Canadian Association of Gastroenterology