Produção Nacional
Revisado por pares
Stefan Lötters, Amadeus Plewnia, Alessandro Catenazzi, Kelsey Neam, Andrés R. Acosta‐Galvis, Yesenia Alarcon Vela, Joshua P. Allen, Juan O. Alfaro Segundo, Ana de Lourdes Almendáriz Cabezas, Gilbert Alvarado Barboza, Kleiton Rodolfo Alves-Silva, Marvin Anganoy‐Criollo, Ernesto Arbeláez Ortiz, Jackeline D. Arpi Lojano, Alejandro Arteaga, Onil Ballestas, Diego Barrera Moscoso, José D. Barros-Castañeda, Abel Batista, Manuel Hernando Bernal, Esteban Betancourt, Youszef Oliveira da Cunha Bitar, Philipp Böning, Laura Bravo‐Valencia, José F. Andrade, Diego A Cadenas, Juan Carlos Chaparro Auza, Giovanni A. Chaves-Portilla, Germán Chávez, Luis A. Coloma, Claudia F. Cortez-Fernandez, Élodie A. Courtois, Jaime Culebras, Ignacio De la Riva, Vladimir Rojas Díaz, Luis C. Elizondo Lara, Raffael Ernst, Sandra V. Flechas, Thibaut Foch, Antoine Fouquet, Carmen Z. García Méndez, Juan E. García-Pérez, Diego A. Gómez-Hoyos, Samuel Campos Gomides, Jorge Guerrel, Brian Gratwicke, Juan M. Guayasamin, Edgardo Griffith, Valia Herrera-Alva, Roberto Ibáñez, Carlos Iván Idrovo, A. Monge, Rafael F. Jorge, Alisha Jung, Blake Klocke, Margarita Lampo, Edgar Lehr, Carrie Lewis, Erik D. Lindquist, Yeny Rocío López-Perilla, Glib Mazepa, Guido Fabián Medina-Rangel, Andrés Merino‐Viteri, Kevin P. Mulder, Mauricio Pacheco-Suarez, Andry Pereira-Muñoz, José Luis Pérez-González, Maria Alejandra Pinto Erazo, Adolfo Gustavo Pisso Florez, Marcos Ponce, Vicky Poole, Amanda Quezada, Aarón J. Quiroz, Michelle Quiroz-Espinoza, Alejandro Ramírez Guerra, Juan P. Ramírez, Steffen Reichle, Hugo Reizine, Mauricio Rivera‐Correa, B. Ross, Andrés Rocha-Usuga, Miguel Tréfaut Rodrigues, Sintana Rojas Montaño, Daniela C. Rößler, Luis Alberto Rueda Solano, J. Celsa Señaris, Alexander Shepack, Fausto Rodrigo Siavichay Pesántez, Anton Sorokin, Andrea Terán-Valdéz, Grecia Torres-Ccasani, Pablo C. Tovar-Siso, Lina M. Valencia, David A. Trujillo, Michael Veith, Pablo J. Venegas, Jeferson Villalba-Fuentes, Rudolf von May, Juan Fernando Webster Bernal, Enrique La Marca,
Abstract Biodiversity loss is extreme in amphibians. Despite ongoing conservation action, it is difficult to determine where we stand in overcoming their extinction crisis. Among the most threatened amphibians are the 131 Neotropical harlequin toads. Many of them declined since the 1980s with several considered possibly extinct. Recently, more than 30 species have been rediscovered, raising hope for a reversing trend in the amphibian extinction crisis. We use past and present data available for ...
Tópico(s): Species Distribution and Climate Change
2023 - Nature Portfolio | Communications Earth & Environment
Petra ter Brugge, Sarah C. Moser, Ivan Bièche, Petra Kristel, Sabrina Ibadioune, Alexandre Eeckhoutte, Roebi de Bruijn, Eline van der Burg, Catrin Lutz, Stefano Annunziato, Julian de Ruiter, Julien Masliah‐Planchon, Sophie Vacher, Laura Courtois, Rania El Botty, Ahmed Dahmani, Élodie Montaudon, Ludivine Morisset, Laura Sourd, Léa Huguet, Héloïse Derrien, Fariba Némati, Sophie Château‐Joubert, Thibaut Larcher, Anne Vincent‐Salomon, Didier Decaudin, Fabien Reyal, Florence Coussy, Tatiana Popova, Jelle Wesseling, Marc‐Henri Stern, Jos Jonkers, Elisabetta Marangoni,
Abstract The high frequency of homologous recombination deficiency (HRD) is the main rationale of testing platinum-based chemotherapy in triple-negative breast cancer (TNBC), however, the existing methods to identify HRD are controversial and there is a medical need for predictive biomarkers. We assess the in vivo response to platinum agents in 55 patient-derived xenografts (PDX) of TNBC to identify determinants of response. The HRD status, determined from whole genome sequencing, is highly predictive ...
Tópico(s): BRCA gene mutations in cancer
2023 - Nature Portfolio | Nature Communications
Kévin Bigaut, Laurent Kremer, Thibaut Fabacher, Guido Ahle, Mathilde Goudot, Marie Fleury, C. Gaultier, Sylvie Courtois, Nicolas Collongues, de Sèze,
Exit strategy after natalizumab cessation in multiple sclerosis (MS) is a crucial point because the risk of disease reactivation is high during this period. The objective of this observational study was to compare ocrelizumab to fingolimod after natalizumab cessation in patients with relapsing–remitting multiple sclerosis (RRMS). All RRMS patients starting fingolimod or ocrelizumab within 6 weeks after natalizumab cessation were included. The primary endpoint was the annualized relapse rate (ARR) at ...
Tópico(s): Peripheral Neuropathies and Disorders
2022 - Springer Science+Business Media | Journal of Neurology
Thibaut Eguether, Maria Ermolaeva, Yongge Zhao, Marion Bonnet, Ashish Jain, Manolis Pasparakis, Gilles Courtois, Anne‐Marie Tassin,
CYLD is a tumour suppressor gene mutated in familial cylindromatosis, a genetic disorder leading to the development of skin appendage tumours. It encodes a deubiquitinating enzyme that removes Lys63- or linear-linked ubiquitin chains. CYLD was shown to regulate cell proliferation, cell survival and inflammatory responses, through various signalling pathways. Here we show that CYLD localizes at centrosomes and basal bodies via interaction with the centrosomal protein CAP350 and demonstrate that CYLD ...
Tópico(s): Histiocytic Disorders and Treatments
2014 - Nature Portfolio | Nature Communications
Thomas Pierre, Édouard Geslain, Mickaël Courtois, Anthony Magueresse, Thibaut Colinart,
This work presents a methodology to estimate the in-plane thermal diffusivity through infrared thermography. Experimentally, a vertical thin-thickness sample is briefly heated on its center by Joule effect and one face is filmed by an infrared camera. The experimental temperature field is compared with an analytical axisymmetric semi-infinite thermal model. The in-plane thermal diffusivity and a modified Biot number are estimated through a least square method based on the minimization of the quadratic ...
Tópico(s): Geothermal Energy Systems and Applications
2021 - Elsevier BV | Infrared Physics & Technology
Kévin Bigaut, Thibaut Fabacher, Laurent Kremer, Jean-Claude Ongagna, Arnaud Kwiatkowski, François Sellal, D. Ferriby, Sylvie Courtois, Patrick Vermersch, Nicolas Collongues, Hélène Zéphir, de Sèze, Olivier Outteryck,
Data are needed on long-term effect of natalizumab (NTZ) in relapsing-remitting multiple sclerosis (RRMS).To evaluate the time of onset of secondary progressive phase in patients with an RRMS treated with NTZ and to investigate predictive factors.TYSTEN is an observational study. Patients starting NTZ between 2007 and 2012 were included and followed up until October 2018. Relapses, Expanded Disability Status Scale (EDSS) scores, and results of brain magnetic resonance imaging (MRI) were collected each ...
Tópico(s): Systemic Lupus Erythematosus Research
2020 - SAGE Publishing | Multiple Sclerosis Journal
Caroline Charlier, Élodie Perrodeau, Alexandre Leclercq, B. Cazenave, Benoît Pilmis, Benoît Henry, Amanda Lopes, Mylène M. Maury, Alexandra Moura, François Goffinet, Hélène Dieye, Pierre Thouvénot, Marie‐Noëlle Ungeheuer, Mathieu Tourdjman, V. Goulet, Henriette de Valk, Olivier Lortholary, Philippe Ravaud, Marc Lecuit, Pierre Hausfater, Jean-Louis Pourriat, Enrique Casalino, Bruno Riou, Dominique Pateron, Patrick Yéni, François Bricaire, Y. Ville, Élie Azria, Marc Dommergues, Jean‐François Bergmann, Michel Wolff, Jean‐Paul Mira, Loı̈c Guillevin, Mathieu Zuber, Soumeth Abasse, Saïd Aberrane, P. Abgueguen, Ayman Abokasem, Bruno Abraham, Chantal Ache-Papillon, Pascal Adam, M. N. Adam, Xavier Adhoute, D. Adoué, Moncef Afi, N. Afroukh, Ilhem Agha-Mir, Nejla Aissa, Liamine Aissaoui, G. Akerman, Ali Akkari, Majed Al Chaar, Faraj Al Freijat, Bachar Al-Jalaby, Didier Albert, Marie-Thérèse Albertini, Hélène Albinet, Gwenaël Alfonsi, Youssef Ali, Zahr-Eddine Ali Chaouche, Anne Allart, Laurent Alric, A. Améri, Zahir Amoura, Alexandre Ampère, Hakim Amroun, Amévi Ananivi, Pascal Ancelin, Thierry André, Antoine Andremont, Dominique Andreotti, Hélinoro Andriamaneo, Clara Andriau, Hélène Anglaret, Nadia Anguel, Véronique Annaix, Wassila Anteur, D. Anuset, Ourida Aoudia, Miloud Arabi, Muriel Archambaud, M. Archambaud, E. Ardiet, Laurent Argaud, S. Arista, Guillaume Arlet, Jean Armengaud, Jean-Michel Arnal, Isabelle Arnault, Olivier Arsène, Z. Assaf, Assi Assi, David Assouline, Dominique Astruc, Y. Aubard, Claude Aubert, Jean-Paul Aubry, Marc Auburtin, Philippe Aucher, Philippe Audeguy, J P Audie, Hugues Aumaître, Michel Aumersier, Jean Auroux, Fanny Autret, Etienne Auvray, Badih Ayach, Paul Aye, Khélifa Ayouz, Élie Azria, Marie-Nadège Bachelier, Thomas Bachelot Philippe Badia, Patrice Badila, Julien Bador, Viorica Badurescu, Olivier Baldési, Françoise Bandaly, Olivia Bandin, Firouzé Bani‐Sadr, Stéphanie Bannier, Thierry Baranger, I. Barazer, Marie-Christine Barbier, François Barbier, Carole Barbier, Marianne Barbieux, Marie, Annick Barboteau, Patricia Barbut, Mylène Baret, François Barière, J.-G. Baril, I. Barillot, Geneviève Barjon, Guilène Barnaud, Régine Barraduc, Francis Barraud, Olivier Barraud, Éric Barré, Audrey Barrelet, Jocelyn Barrier, Frédéric Bart, Gérard Barthélémy, Gaëlle Baty, Olivier Baud, Jean-Luc Baudel, Jacques-Olivier Bay, Jérôme Bay, Dominique Bazin, Sébastien Beague, Dominique Beal Ardisson, Bertrand Beaune, Anne Beauplet-Lepage, Cécile Bébéar, Dominique Bechade, Céline Becherrawy, Michelle Becker-Schneider, Nathalie Bednarek, B. Bedock, Edouard Begon, Zaineb Bekguesmia, Joëlle Belaisch-Amart, Karim Belhadj, Evelyne Belle, Olivier Belmonte, Jean-Pierre Belot, Abdelkader Bemrah, Mouna Ben Soltana, Amélie Benbara, Faiza Benddif-Fin, François Bénézit, Jean-Louis Benifla, Amine Benjelloul, Yacine Benkaci, Abdelaziz Benkhelil, Thierry Benoit-Cattin, Sophie Benoit-Coustou, René-Jean Bensadoun, Thierry Bensaid, Raoul Jacques Bensaude, H. Bérard, Béatrice Berçot, Bruno Berdin, Marc Berger, Pierre Berger, S Bergheul, Jean‐François Bergmann, Benoît Bergues, Yvon Berland, Claude C.A. Bernard, Louis Bernard, Bérangère Bernardaud, Franck Bernardi, Gilles Bernardin, François Bernasconi, Patrick Bert-Marcaz, Béatrice Berteaux, Anne Berth-Farges, Gilles Berthelot, J Berthet, Kevin Bertrand, Anne Bertrou, Marianne Besnard, Emilie Bessede, Philippe Bethery, C. Beuscart, Odile Beyne-Rauzy, Jean Beytout, Marie-Christine Bezian, Brigitte Bicais, Sabine Bidart, Christian Bidault, Hélène Biessy, Pierre Bigot, Adrianna Bildea, Emmanuelle Bille, Christophe Billy, Nathalie Biron, J. Bizet, Didier Blaise, Agathe Blaise, Gilles Blaison, Mariam Blaka, Pierre Blanc, Stéphane Blanc, V. Blanc-Amrane, Pierre Blanchard, Geneviève Blanchard-Marche, Michèle Blancs, Caroline Blazejewski, Yves Bléher, Koffi Blewoussi, Romain Blondet, François Blot, G. Blum, Lucien Bodson, Emilie Boidin, J. Boileau, Pascal Boileau, Véronique Boin-Gay, Martial Boisseau, Christine Boisselier, Pierre‐Édouard Bollaert, Pascal Bolot, Stéphane Bonacorsi, Marie Bonfils, Pascal Bonitchi, Mickaël Bonnan, Philippe A. Bonnefoy, Delphine Bonnet, Richard Bonnet, Emmanuelle Bonnin, Jacques Bor, Marie-Françoise Borie, Bernard Borstein, Philippe Bossi, Y Botreau, Julie Bottero, Abderrezak Bouasria, Radia Bouaziz, Olivier Bouchaud, Flore Bouche, Gérard Bouchet, Vincent Bouden, Amar Boudhane, Carole-Anne Boudy, François Boue, Cédric Bouet, Jean Claude Boufetteau, B Bouffandeau, Damien Bouhour, M. Bouiller, Laurence Bouillet, Antoine Bouissou, Luc Boulain, S. Bourgeois, Evelyne Bourgerette, Anne Bourlet, Marc Bourlière, Thomas Bourrée, Aude Bourrouillou, Nicolas Boussekey, Remi Boussier, David Boutoille, Jean-Luc Bouyer, Denise Bouyssou-Destriau, N. Bouziges, Michelle Boyer, L. Braem, B. Branger, Catherine Branger, Lucien Brasme, Philippe Bray, Patricia Brazille, V. Bresson, Laurent Bret,
Listeriosis is a severe foodborne infection and a notifiable disease in France. We did a nationwide prospective study to characterise its clinical features and prognostic factors.MONALISA was a national prospective observational cohort study. We enrolled eligible cases declared to the National Reference Center for Listeria (all microbiologically proven) between Nov 3, 2009, and July 31, 2013, in the context of mandatory reporting. The outcomes were analysis of clinical features, characterisation ...
Elsevier BV
Aurélie Cabannes‐Hamy, Lucien Courtois, Marie Balsat, Mathieu Simonin, Françoise Huguet, Martine Escoffre‐Barbe, Florence Pasquier, Caroline Bonmati, Pascal Turlure, Thomas Cluzeau, Delphine Lebon, Eve Gehlkopf, Éolia Brissot, Justine Decroocq, Patrice Chevallier, Sylvain Chantepie, Victoria Cacheux, Sébastien Maury, Safia Chebrek, Thibaut Leguay, M. Fort, Natacha Mauz, Mathlide Lamarque, Hunault-Berger Mathilde, Stefan Wickenhauser, Jamilé Frayfer, Anne Banos, Emmanuelle Tavernier, Denis Caillot, Anne Marie Ronchetti, Céline Berthon, Étienne Lengliné, Véronique Lhéritier, Hervé Dombret, Ambroise Marçais, Antoine Pinton, Guillaume P. Andrieu, Nicolas Boissel, Ludovic Lhermitte, Vahid Asnafi, Philippe Rousselot,
Introduction T-cell acute lymphoblastic leukemia (T-ALL) is an orphan disease diagnosed mostly in adolescent and young adults. In adult population, 5-10% of T-ALL patients (pts) will be primary refractory and 30-40% will relapse. In relapse/refractory (R/R) patients, standard of care treatments, including nelarabine, yield response rate of about 20-40% and responses are of short duration. On behalf of the GRAALL (Group for Research on Adult Acute Lymphoblastic Leukemia), we launched the ALL-TARGET project ...
Tópico(s): Acute Lymphoblastic Leukemia research
2023 - Elsevier BV | Blood
E. Courtois, Thi Thu Ha Nguyen, Alice Fournier, Sylvie Escolano, Pascale Tubert‐Bitter, Alexis Elbaz, A. Thibaut, Ismaïl Ahmed,
La maladie de Parkinson (MP) est celle dont la prévalence augmente le plus rapidement parmi les maladies neurologiques alors que les traitements disponibles ne sont que partiellement ou transitoirement efficaces. Une stratégie prometteuse consiste à identifier des molécules existantes pouvant présenter un avantage thérapeutique voire préventif pour la MP (repositionnement de médicaments). Notre objectif était de détecter des associations potentiellement protectrices entre médicaments commercialisés ...
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2022 - Elsevier BV | Revue d Épidémiologie et de Santé Publique
Laurent Kremer, de Sèze, Thibaut Fabacher, Marie‐Céline Fleury, Guido Ahle, Sylvie Courtois, Kévin Bigaut,
Une réactivation de la sclérose en plaques rémittente-récurrente (SEP-RR) a été décrite après arrêt du natalizumab (NTZ). Cependant, des données avec des traitements récents comme l’ocrelizumab sont manquantes. L’objectif était de comparer l’efficacité du fingolimod et de l’ocrelizumab en relais du NTZ dans la SEP-RR. Dans cette étude observationnelle, tous les patients SEP-RR traités par fingolimod ou ocrelizumab en relais du NTZ (relais < 60 jours) ont été inclus. Les patients qui ont arrêté le fingolimod ...
Tópico(s): Chronic Lymphocytic Leukemia Research
2021 - Elsevier BV | Revue Neurologique
Thibaut Eguether, BM Bonnet, EM Ermolaeva, PM Pasparakis, CG Courtois, TAM Tassin,
The tumor suppressor CYLD gene encodes a deubiquitinating enzyme that removes lys-63-linked ubiquitin chains. CYLD regulates, by its catalytic domain, NF-kB, c-Jun kinase and Wnt/β-catenin signalling pathways. When mutated in its catalytic domain CYLD cause skin appendages tumors as in familial cylindromatosis. We have found CYLD as a partner of the centrosomal protein CAP350 in immunoprecipitation experiments followed by mass spectrometry. CAP350 was shown to play a role in microtubule stabilization ( ...
Tópico(s): Cancer-related Molecular Pathways
2012 - Springer Science+Business Media | Cilia