Cédric Pastoret, Roch Houot, Francisco Llamas‐Gutierrez, Marie‐Laure Boulland, Tony Marchand, Patrick Tas, Béatrice Ly-Sunnaram, Virginie Gandemer, Thierry Lamy, Mikaël Roussel, Thierry Fest,
Myeloid sarcoma (MS) are extramedullary tumor masses consisting of a proliferation of myeloid immature cells that efface the underlying tissue architecture.[1] It may develop de novo or concurrentl...
Tópico(s): Vascular Tumors and Angiosarcomas
2016 - Taylor & Francis | Leukemia & lymphoma/Leukemia and lymphoma
F. Velge-Roussel, Thierry Chardès, P. Mévélec, M. Brillard, Johan Hoebeke, Daniel Bout,
T and B cell epitopes of the major Toxoplasma gondii surface antigen SAG1 were studied following CNBr fragmentation. Three fragments, F1, F2 and F3, were obtained, of 19, 16.5 and 14 kDa, respectively. The positions of F1 F2 and F3 within the SAG1 protein were identified by N-terminal sequence determination. The F1 fragment located on residues 125-269 contains the C-terminus, and the fragment F2 (residues 1-124) is located at the N-terminal region. F3 is a C-terminal peptide about 40 amino acids ...
Tópico(s): Chemical Synthesis and Analysis
1994 - Elsevier BV | Molecular and Biochemical Parasitology
Benoît Bareau, Jérôme Rey, M. Hamidou, Jean Donadieu, Jeff Morçet, Oumédaly Reman, N. Schleinitz, Olivier Tournilhac, Mikaël Roussel, Thierry Fest, T. Lamy,
Large granular lymphocyte leukemia is a rare lymphoproliferative disorder associated with autoimmune diseases and impaired hematopoiesis. This study describes the clinical and biological characteristics of 229 patients with T-cell or NK-cell large granular lymphocyte leukemia.The diagnosis was based on a large granular lymphocyte expansion (> 0.5x10(9)/L) lasting more than 6 months. Monoclonal T-cell receptor gamma gene rearrangement was detected in all the cases of T-cell large granular lymphocyte ...
Tópico(s): Chronic Myeloid Leukemia Treatments
2010 - Ferrata Storti Foundation | Haematologica
Hervé Avet‐Loiseau, Denis Caillot, Gérald Marit, Valérie Lauwers‐Cancès, Murielle Roussel, Thierry Façon, Cyrille Hulin, Thierry Lamy, Brigitte Pegourié, Hervé Maisonneuve, Laurent Garderet, Philippe Moreau, Anne‐Marie Stoppa, Mamoun Dib, J. Jaubert, Philippe Casassus, Claire Mathiot, Jean‐Luc Harousseau, Philippe Moreau, Michel Attal,
Abstract Abstract 1944 Cytogenetic abnormalities have been associated with specific outcome in myeloma, as in many other hematologic malignancies. Among the large spectrum of chromosomal changes observed in myeloma, at least two of them are clearly associated with a specific poor outcome, both in terms of PFS and OS, i.e., t(4;14) and del(17p). Recent data suggested that bortezomib can at least partially overcome the prognostic value of t(4;14). However, t(4;14) remains a prognostic factor in the ...
Tópico(s): Cancer Treatment and Pharmacology
2010 - Elsevier BV | Blood
Bach‐Nga Pham, Michèle Roussel, Thierry Peyrard, Marylise Beolet, Véronique Jan‐Lasserre, Dominique Gien, Maryline Ripaux, Sébastien Bourgouin, Sandrine Kappler‐Gratias, Philippe Rouger, Pierre‐Yves Le Pennec,
Whether anti-D produced by individuals with a weak D phenotype are allo- or autoantibodies remains a matter of debate even though blood transfusion practice is impacted. The aim of our study was to determine the serologic features of anti-D in individuals expressing the most frequent weak D type in Caucasians that are weak D Type 1 or weak D Type 2, to assess whether anti-D were allo- or autoantibodies.Serologic D typing and molecular analysis enabled the including of 121 weak D Type 1 individuals ...
Tópico(s): Platelet Disorders and Treatments
2011 - Wiley | Transfusion
Jérôme Lhoste, Natacha Henry, Pascal Roussel, Thierry Loiseau, F. Abraham,
A novel uranyl-organic compound incorporating citrate linker exhibits a 3D open-framework. It is built up from the connection of infinite chains of uranyl-centered polyhedra with citrate ligands, generating layers, which are further linked perpendicularly by isolated uranium tetranuclear motifs, involving uranyl cation-cation interactions.
Tópico(s): Lanthanide and Transition Metal Complexes
2011 - Royal Society of Chemistry | Dalton Transactions
Murielle Roussel, Thierry Façon, Philippe Moreau, Jean‐Luc Harousseau, Michel Attal,
High dose therapy (HDT) with autologous stem cell transplantation (ASCT) is the standard of care for eligible newly diagnosed MM patients. Several randomized studies demonstrated a survival advantage for patients undergoing transplantation, compared with conventional chemotherapy. Introduction of new drugs in this setting have markedly increased survival rates within the last 10 years. Efforts to further improve response rates and survival in those patients are still needed, mainly by increasing the ...
Tópico(s): Peptidase Inhibition and Analysis
2011 - Springer Science+Business Media | Recent results in cancer research/Recent Results in Cancer Research
David Gall, Céline Roussel, Thierry Nieus, Guy Chéron, Laurent Servais, Egidio D’Angelo, Serge N. Schiffmann,
Calcium binding proteins, such as calretinin, are abundantly expressed in distinctive patterns in the central nervous system but their physiological function remains poorly understood. Calretinin is expressed in cerebellar granule cells which provide the major excitatory input to Purkinje cells through parallel fibers. Calretinin deficient mice exhibit dramatic alterations in motor coordination and in Purkinje cell firing recorded in vivo through unknown mechanisms. In the present paper, we review ...
Tópico(s): Ion channel regulation and function
2005 - Elsevier BV | Progress in brain research
Myriam Roussel, Thierry Benvegnu, Vincent Lognoné, Hervé Le Deit, Isabelle Soutrel, Isabelle Laurent, Daniel Plusquellec,
Abstract The present article describes the preparation and the physico‐chemical properties of novel biocompatible surfactants derived from alginate for applications in detergents and cosmetics. Controlled acid hydrolysis of commercially available alginate from Laminaria digitata gives saturated oligo‐mannuronates on a multigram scale. Subsequent one‐pot acid glycosidic bond hydrolysis, esterification and stereocontrolled Fischer glycosylation in butanol with the related oligouronates efficiently ...
Tópico(s): Enzyme Catalysis and Immobilization
2005 - Wiley | European Journal of Organic Chemistry
Solveig Roussel, Thierry Billard, Bernard R. Langlois, Laurent Saint‐James,
Abstract Various trifluoroacetamides and trifluoromethanesulfinamides, derived from chiral silylated amino alcohols, have been synthesized with the goal of achieving enantioselective nucleophilic trifluoromethylation. The best results were obtained with ( R )‐phenylglycinol derivatives, but the ee values did not exceed 30 %.
Tópico(s): Carbohydrate Chemistry and Synthesis
2004 - Wiley | Chemistry - A European Journal
Aline Moignet, Zainul S. Hasanali, Renato Zambello, Laura Pavan, Benoît Bareau, Olivier Tournilhac, Mikaël Roussel, Thierry Fest, Amir Awwad, Kendall Thomas Baab, Gianpietro Semenzato, Roch Houot, Thomas P. Loughran, Thierry Lamy,
HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not.The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, ...
Tópico(s): Immunodeficiency and Autoimmune Disorders
2013 - Springer Nature | Leukemia
Emmanuel Nony, Julien Bouley, Maxime Le Mignon, P. Lemoine, K. Jain, S. Horiot, Laurent Mascarell, Marc Pallardy, Renaud Vincentelli, Patrizia Leone, A. Roussel, Thierry Batard, Kathy Abiteboul, B. Robin, Olivier Beaumont, Monica Arvidsson, S. Rak, Philippe Moingeon,
Sublingual immunotherapy (SLIT) applied to type I respiratory allergies is commonly performed with natural allergen extracts. Herein, we developed a sublingual tablet made of pharmaceutical-grade recombinant Bet v 1.0101 (rBet v 1) and investigated its clinical safety and efficacy in birch pollen (BP)-allergic patients.Following expression in Escherichia coli and purification, rBet v 1 was characterized using chromatography, capillary electrophoresis, circular dichroism, mass spectrometry and crystallography. ...
Tópico(s): Food Allergy and Anaphylaxis Research
2015 - Wiley | Allergy
Sylvain Duval, S. Sobanska, Pascal Roussel, Thierry Loiseau,
Nanosized uranium clusters involving a rare U VI O–U IV bonding linkage are stabilized by the B-α-[AsW 9 O 33 ] polyanionic unit.
Tópico(s): Radioactive element chemistry and processing
2015 - Royal Society of Chemistry | Dalton Transactions
Emmanuel Bachy, Mirjam Urb, Shilpi Chandra, Rémy Robinot, Gabriel Bricard, Simon de Bernard, Alexandra Traverse‐Glehen, Sophie Gazzo, Olivier Blond, Archana Khurana, Lucile Baseggio, Tayla B. Heavican, Martine Ffrench, Giuliano Crispatzu, Paul Mondière, Alexandra Schrader, Morgan Taillardet, Olivier Thaunat, Nadine Martin, Stéphane Dalle, Magali Le Garff‐Tavernier, Gilles Salles, Joël Lachuer, Olivier Hermine, Vahid Asnafi, Mikaël Roussel, Thierry Lamy, Marco Herling, Javeed Iqbal, Laurent Buffat, Patrice N. Marche, Philippe Gaulard, Mitchell Kronenberg, Thierry Defrance, Laurent Genestier,
Peripheral T cell lymphomas (PTCLs) are a heterogeneous entity of neoplasms with poor prognosis, lack of effective therapies, and a largely unknown pathophysiology. Identifying the mechanism of lymphomagenesis and cell-of-origin from which PTCLs arise is crucial for the development of efficient treatment strategies. In addition to the well-described thymic lymphomas, we found that p53-deficient mice also developed mature PTCLs that did not originate from conventional T cells but from CD1d-restricted ...
Tópico(s): T-cell and B-cell Immunology
2016 - Rockefeller University Press | The Journal of Experimental Medicine
Manon Létiche, Étienne Eustache, Jérémy Freixas, Arnaud Demortière, Vincent De Andrade, Laurence Morgenroth, Pascal Tilmant, F. Vaurette, David Troadec, Pascal Roussel, Thierry Brousse, Christophe Lethien,
Nowadays, millimeter scale power sources are key devices for providing autonomy to smart, connected, and miniaturized sensors. However, until now, planar solid state microbatteries do not yet exhibit a sufficient surface energy density. In that context, architectured 3D microbatteries appear therefore to be a good solution to improve the material mass loading while keeping small the footprint area. Beside the design itself of the 3D microbaterry, one important technological barrier to address is ...
Tópico(s): ZnO doping and properties
2016 - Wiley | Advanced Energy Materials
L. Duteil, Jane Esdaile, Yves Maubert, Anne‐Claire Cathelineau, Anne Bouloc, Catherine Queille‐Roussel, Thierry Passeron,
Summary Background Until now, photoprotection of human skin has involved the development of sunscreens effective in the ultraviolet ( UV ) domain. During the last ten years, several studies have shown that besides the well‐known damaging effects of UV , visible (400‐700 nm) and even infrared light (> 700 nm) can induce damage which contributes to photoaging. Furthermore, many photodermatoses are also known to be triggered by visible light ( VL ). Objective/Method An in vivo method is proposed to assess the protective ...
Tópico(s): Dermatologic Treatments and Research
2017 - Wiley | Photodermatology Photoimmunology & Photomedicine
Vivek S. Raut, Marion Jean, Nicolas Vanthuyne, Christian Roussel, Thierry Constantieux, Cyril Bressy, Xavier Bugaut, Damien Bonne, Jean Rodriguez,
For the first time, enantiomerically enriched atropoisomeric furans have been accessed using a central-to-axial chirality conversion strategy. Hence, oxidation of the enantioenriched dihydrofuran precursors gave rise to axially chiral furans with high enantiopurities accounting from excellent conversion percentages (cp) in most cases.
Tópico(s): Asymmetric Synthesis and Catalysis
2017 - American Chemical Society | Journal of the American Chemical Society
Kévin Robert, Camille Douard, Arnaud Demortière, Florent Blanchard, Pascal Roussel, Thierry Brousse, Christophe Lethien,
Abstract Micro‐supercapacitors (MSC) are considered as promising miniaturized electrochemical energy storage devices for Internet of Things applications. Unfortunately, the technological readiness level of these devices is still at the lab scale with the development of individual prototypes due to the difficulty to produce high performance porous electrode material with microelectronic equipment available in pilot production lines. Here, the collective fabrication of on chip MSC based on sputtered ...
Tópico(s): Electrocatalysts for Energy Conversion
2018 - Wiley | Advanced Materials Technologies
Morgan Le Guen, Céline Roussel, Thierry Chazot, Guy A. Dumont, N. Liu, Marc Fischler,
Summary Sugammadex, a specific reversal agent for steroidal neuromuscular blocking drugs, has on occasion been reported to be associated with clinical signs of awakening. We performed a study to systematically search for an increase in bispectral index values and signs of awakening in patients maintained under general anaesthesia following sugammadex administration. Patients, scheduled to receive general anaesthesia with neuromuscular blockade, were included in this double‐blind randomised crossover ...
Tópico(s): Anesthesia and Pain Management
2019 - Wiley | Anaesthesia
Kévin Robert, Didier Stiévenard, D. Deresmes, Camille Douard, Antonella Iadecola, David Troadec, Pardis Simon, Nicolas Nuns, Maya Marinova, Marielle Huvé, Pascal Roussel, Thierry Brousse, Christophe Lethien,
Unveiling the charge storage mechanism of vanadium nitride to defy the limits of on-chip micro-supercapacitors.
Tópico(s): Advancements in Battery Materials
2020 - Royal Society of Chemistry | Energy & Environmental Science
Cédric Pastoret, Fabienne Desmots, Gaëlle Drillet, Simon Le Gallou, Marie‐Laure Boulland, Alexia Thannberger, Anne‐Violaine Doncker, Véronique Salaün, Gandhi Damaj, Richard Veyrat‐Masson, Olivier Tournilhac, Aline Moignet, Céline Pangault, Mikaël Roussel, Thierry Fest, Thierry Lamy,
Abstract Distinguishing chronic lymphoproliferative disorders of NK cells (CLPD-NK) from reactive NK-cell expansion is challenging. We assessed the value of killer immunoglobulin-like receptor(KIR) phenotyping and targeted high-throughput sequencing in a cohort of 114 consecutive patients with NK cell proliferation, retrospectively assigned to a CLPD-NK group (n = 46) and a reactive NK group (n = 68). We then developed an NK-cell clonality score combining flow cytometry and molecular profiling with a positive ...
Tópico(s): Autoimmune and Inflammatory Disorders Research
2021 - Elsevier BV | Blood
B. Asbani, Kévin Robert, Pascal Roussel, Thierry Brousse, Christophe Lethien,
Research on micro-supercapacitors remains one of the most important activities in the area of electrochemical energy storage for powering smart and miniaturized electronic devices. Here we design an asymmetric micro-supercapacitor (A-MSC) combining sputtered vanadium nitride film (VN) and electrodeposited hydrous ruthenium oxide (hRuO2) film. Taking advantage of their complementary electrochemical potential windows in 1 M KOH electrolyte, the A-MSC achieves a cell voltage up to 1.15 V, associated to ...
Tópico(s): Advanced Sensor and Energy Harvesting Materials
2021 - Elsevier BV | Energy storage materials
B. Asbani, Gaëtan Buvat, Jérémy Freixas, Marielle Huvé, David Troadec, Pascal Roussel, Thierry Brousse, Christophe Lethien,
To power the next generation of miniaturized electronic devices, 3D micro-supercapacitors are a new class of millimeter scale electrochemical capacitors with superior storage performance than their planar counterparts. Nevertheless, it is mandatory to carefully match the dimensions of the 3D scaffold with the thickness of the electrochemically active electrode materials to take benefit from both the high capacitance values and the high rate capability of 3D micro-supercapacitors technology. Here ...
Tópico(s): Advanced battery technologies research
2021 - Elsevier BV | Energy storage materials
Sylvain Duval, Xavier Trivelli, Pascal Roussel, Thierry Loiseau,
The reaction of Na 10 [α‐SiW 9 O 34 ] with 4f tetravalent cerium cations in aqueous solution in the presence of sodium acetate at different pH values leads to the stabilization of three cerium‐based polyanionic molecular clusters [Ce 3 (µ 2 ‐OH) 3 (µ 3 ‐O)(SiW 9 O 34 ) 2 ] 13– ( 1 ), [Ce 3 (µ 2 ‐O) 3 (SiW 9 O 34 ) 2 ] 14– ( 2 ), and {[Ce 6 (µ 3 ‐O) 4 (µ 3 ‐OH) 4 ] 2 (W 8 O 32 )(SiW 9 O 34 ) 4 } 32– ( 3 ). The condensation behavior of cerium in this kind of association with trivacant polyoxometalates (POMs) when a pH variation occurs is relatively ...
Tópico(s): Advanced Nanomaterials in Catalysis
2016 - Wiley | European Journal of Inorganic Chemistry
Sandrine Marie, Fabienne Roussel, Thierry Cresteil,
A cDNA was isolated from a library prepared with 15-day-old rat liver RNA and was shown to correspond to CYP2C23 with some minor alterations which modified the open reading frame. The expression of CYP2C23 was examined in rat liver, kidney, lung and testis and during ontogenesis. An appreciable amount of CYP2C23 RNA was observed in liver and kidney but the age-dependent expression was quite different between these two tissues. In liver, expression reached its maximal value in early neonates and ...
Tópico(s): Drug Transport and Resistance Mechanisms
1993 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression
Sylvain Duval, Pascal Roussel, Thierry Loiseau,
Addition of an excess of tetravalent cerium over the SiW9O34 polyoxometalates in 1 M sodium acetate buffer at pH = 4.7 leads in second crystallization to the unprecedented dodecameric cerium cluster [{Ce6(μ3-O)4(μ3-OH)3-(μ4-O)2-Ce6(μ3-O)4(μ3-OH)3}(CH3COO)13(SiW9O34)2]11 −. This compound has been characterized by IR spectroscopy, TGA, single crystal and powder X-Ray diffraction, SEM, EDS, ICP-OES.
Tópico(s): Advanced Nanomaterials in Catalysis
2017 - Elsevier BV | Inorganic Chemistry Communications
Natalie Stieltjes, Marie F Torchet, Laure Misrahi, V. Roussel‐Robert, Thierry Lambert, C Guérois, Marie Anne Bertrand, Marie Elisabeth Briquel, Annie Borel‐Derlon, G Dirat,
The physical condition of severe haemophilia and the impact of advances in replacement therapy have been much studied, but little work has been done on patients who developed inhibitors. The 'Statut Orthopédique des Patients Hémophiles avec Inhibiteur' study was conducted in France in order to assess the orthopaedic status and quality of life of such patients, and the cost of their medical management. Fifty haemophiliacs aged 12-63 years with a history of high-responder inhibitors were included. ...
Tópico(s): Hemostasis and retained surgical items
2008 - Lippincott Williams & Wilkins | Blood Coagulation & Fibrinolysis
Saad Nseir, Christophe Di Pompéo, Stéphane Soubrier, Pierre Delour, Hélène Lenci, Micheline Roussel‐Delvallez, Thierry Onimus, F. Saulnier, Daniel Mathieu, Alain Durocher,
Objective: The objective of this study was to determine the relationship between fluoroquinolone (FQ) use and subsequent emergence of multiple drug-resistant bacteria (MRB) in the intensive care unit (ICU). Design: The authors conducted a prospective observational cohort study and a case control study. Setting: The study was conducted in a 30-bed ICU. Methods: All immunocompetent patients hospitalized for >48 hrs who did not receive antibiotics before ICU admission were eligible during a 15-month period. ...
Tópico(s): Pneumonia and Respiratory Infections
2005 - Lippincott Williams & Wilkins | Critical Care Medicine
Jean‐Sébastien Allain, Florian Thonier, M. Pihan, Marie‐Laure Boulland, Sophie de Guibert, Vincent Launay, Anne‐Violaine Doncker, Michel Ganard, Amyra Aliouat, Céline Pangault, Roch Houot, Marie de Tayrac, Thierry Lamy, Mikaël Roussel, Thierry Fest, Olivier Decaux, Cédric Pastoret,
Tópico(s): Immunodeficiency and Autoimmune Disorders
2018 - Ferrata Storti Foundation | Haematologica
J. Maugein, Didier Guillemot, M.J. Dupont, T. Fosse, G. Laurans, M. Roussel‐Delvallez, J Thierry, M. Vergnaud, M. Weber, B. Poirier,
ObjectiveTo describe the incidence of pneumococcal bacteremia not associated with infection of the central nervous system, investigate the susceptibility of bacterial isolates to β-lactams, evaluate risk factors for antibiotic resistance, and determine factors predicting patient outcome.MethodsOver a period of 1 year, 919 Streptococcus pneumoniae isolates were collected from 919 patients with bacteremia in eight French counties. Their clinical and microbiological features were recorded. Univariate ...
Tópico(s): Bacterial Infections and Vaccines
2003 - Elsevier BV | Clinical Microbiology and Infection