Christian T. Happi, Grace O. Gbotosho, Onikepe Folarin, A. Sowunmi, Thomas Hudson, Michael T. O’Neil, Wilbur K. Milhous, Dyann F. Wirth, A.M.J. Oduola,
We assessed Plasmodium falciparum mdr1 (Pfmdr1) gene polymorphisms and copy numbers as well as P. falciparum Ca(2+) ATPase (PfATPase6) gene polymorphisms in 90 Nigerian children presenting with uncomplicated falciparum malaria and enrolled in a study of the efficacy of artemether-lumefantrine (AL). The nested PCR-restriction fragment length polymorphism and the quantitative real-time PCR methodologies were used to determine the alleles of the Pfmdr1 and PfATPase6 genes and the Pfmdr1 copy number variation, ...
Tópico(s): Parasites and Host Interactions
2008 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
O Walker, L.A. Salako, A. Sowunmi, J Thomas, O. Sodeine, F.S. Bondi,
... Oxford Academic PubMed Google Scholar A. Sowunmi, A. Sowunmi 1Departments of Pharmacology and Therapeutics, University of Ibadan, Ibadan, Nigeria Search for other works by this author on: Oxford Academic PubMed Google Scholar J.O. Thomas, J.O. Thomas 3Department of Pathology, University of ...
Tópico(s): Acute Ischemic Stroke Management
1992 - Oxford University Press | Transactions of the Royal Society of Tropical Medicine and Hygiene
A.M.J. Oduola, A. Sowunmi, Wilbur K. Milhous, Thomas G. Brewer, Dennis E. Kyle, L. Gerena, Richard N. Rossan, L.A. Salako, Brian G. Schuster,
The effect of combining promethazine with chloroquine was examined against Plasmodium falciparum in vitro in the Aotus-P. falciparum model and in bioassays from volunteers given promethazine. The combination of chloroquine plus promethazine (1 x 10(-6) M) reversed chloroquine resistance in standard P. falciparum clones and patient parasite isolates from Nigeria. The combination reduced the 50% inhibitory concentrations (IC50s) for chloroquine against resistant parasites by 32-92%. Coadministration ...
Tópico(s): Infectious Encephalopathies and Encephalitis
1998 - American Society of Tropical Medicine and Hygiene | American Journal of Tropical Medicine and Hygiene
Christian T. Happi, S.M. Thomas, Grace O. Gbotosho, Catherine O. Falade, Dora Akinboye, L. Gerena, Thomas Hudson, A. Sowunmi, Dennis E. Kyle, Wilbur K. Milhous, Dyann F. Wirth, A.M.J. Oduola,
Chloroquine (CQ) resistance in Plasmodium falciparum has been associated with specific point mutations in the pfcrt and pfmdr-1 genes. In the present study, 30 children aged 1-12 years, who were all suffering from acute, uncomplicated, P. falciparum malaria in Ibadan, Nigeria, were evaluated to assess the association between these mutations and clinical outcome following treatment with CQ. The parasites, in blood samples collected pre-treatment and, in those who failed treatment, on the day symptoms ...
Tópico(s): Mosquito-borne diseases and control
2003 - Maney Publishing | Annals of Tropical Medicine and Parasitology
Atara Ntekim, Adenike Adeniji-Sofoluwe, Abiola Ibraheem, Anthonia Sowunmi, Ayorinde Folasire, Thomas Olajide, Olalekan Olasehinde, Akinwunmi O. Komolafe, AbdulRazzak Lawal, Foluso Omodele, Ayodele Sanni, Mustapha Ajani, Olayinka Kotila, Sharifat Folorunsho, Tonyin Aniagwu, Adewumi Alabi, Abiodun Popoola, Chioma Asuzu, Adetola Daramola, Chinedum P. Babalola, Theodore Karrison, FB Abdulkareem, Olufunmilayo I. Olopade,
... Atara Ntekim, Adenike Adeniji-Sofoluwe, Abiola Ibraheem, Anthonia Sowunmi, Ayorinde Folasire, Thomas Olajide, Olalekan Olasehinde, Akinwunmi Komolafe, AbdulRazzak Lawal, Foluso ...
Tópico(s): HER2/EGFR in Cancer Research
2023 - American Association for Cancer Research | Cancer Research
Sarah Fidler, Wolfgang Stöhr, Matthew Pace, Lucy Dorrell, Andrew Lever, Sarah Pett, Sabine Kinloch-de Loës, Julie Fox, Amanda Clarke, Mark Nelson, John Thornhill, Maryam Khan, Axel Fun, Mikaila Bandara, Damian J. Kelly, Jakub Kopycinski, Tomáš Hanke, Hongbing Yang, Rachel Bennett, Margaret Johnson, Bonnie J. Howell, Richard Barnard, Guoxin Wu, Steve Kaye, Mark R. Wills, Abdel Babiker, John Frater, Eric Sandström, Janet Darbyshire, Frank A. Post, Christopher P. Conlon, Jane Anderson, Mala K. Maini, Timothy Peto, Peter Sasieni, Veronica Miller, Ian Weller, Sarah Fidler, John Frater, Abdel Babiker, Wolfgang Stöhr, Sarah Pett, Lucy Dorrell, Matthew Pace, Natalia Olejniczak, Helen Brown, Nicola Robinson, Jakub Kopycinski, Hongbing Yang, Tomáš Hanke, Alison Crook, Steven Kaye, Myra O. McClure, Otto Erlwein, Andrew Lovell, Maryam Khan, Michelle Gabrielle, Rachel Bennett, Aminata Sy, Adam Gregory, Fleur Hudson, Charlotte Russell, Gemma Wood, Hanna Box, Cherry Kingsley, Katie Topping, Andrew Lever, Mark R. Wills, Axel Fun, Mikaila Bandara, Damian J. Kelly, Simon Collins, Alex Markham, Mary Rauchenberger, Yinka Sowunmi, Shaadi Shidfar, Dominic Hague, Mark Nelson, Maddalena Cerrone, Nadia Castrillo Martinez, Tristan Barber, Alexandra Schoolmeesters, Christine Weaver, Orla Thunder, Jane Rowlands, Chris Higgs, Serge Fedele, Margherita Bracchi, Lervina Thomas, Peter Bourke, Nneka Nwokolo, Gaynor Lawrenson, Marzia Fiorino, Hinal Lukha, Sabine Kinloch-de Loës, Margaret Johnson, Alice Nightingale, Nnenna Ngwu, P. S. Byrne, Zoe Cuthbertson, Martin Jones, Tina Fernandez, Amanda Clarke, Martin Fisher, Rebecca Gleig, Vittorio Trevitt, Colin Fitzpatrick, Tanya Adams, Fiounnuala Finnerty, John Thornhill, Heather Lewis, Kristin Kuldanek, Julie Fox, Julianne Lwanga, Hiromi Uzu, Ming Lee, S Merle, P.E.F. O'Rourke, Isabel Jendrulek, Taras ZarkoFlynn, Mark J. Taylor, Juan Tiraboschi, Tammy Murray,
Antiretroviral therapy (ART) cannot cure HIV infection because of a persistent reservoir of latently infected cells. Approaches that force HIV transcription from these cells, making them susceptible to killing-termed kick and kill regimens-have been explored as a strategy towards an HIV cure. RIVER is the first randomised trial to determine the effect of ART-only versus ART plus kick and kill on markers of the HIV reservoir.This phase 2, open-label, multicentre, randomised, controlled trial was undertaken ...
Tópico(s): HIV/AIDS drug development and treatment
2020 - Elsevier BV | The Lancet
Ali Alloueche, W. S. Bailey, Sarah Barton, Juma Bwika, Phillips Chimpeni, CO Falade, F.A. Fehintola, John Horton, Shabbar Jaffar, Thomas P. Kanyok, PG Kremsner, James G. Kublin, Trudie Lang, MA Missinou, Christopher Mkandala, Z Premji, Lindsay Robertson, A. Sowunmi, Stephen A. Ward, PA Winstanley, A.M.J. Oduola,
Background Increasing resistance to sulfadoxine-pyrimethamine is leading to a decline in its effectiveness. We aimed to assess the safety profile of chlorproguanil-dapsone (CD), and to compare the safety and efficacy of this drug with that of sulfadoxine-pyrimethamine (SP) as treatment for uncomplicated falciparum malaria. Methods We undertook a double-blind, randomised trial in 1850 consecutively recruited children with uncomplicated falciparum malaria, pooling data from five African countries. Analyses ...
Tópico(s): Mosquito-borne diseases and control
2004 - Elsevier BV | The Lancet
... 10.1016/j.reprotox.2015.11.006Fatai Abiola Sowunmi Spatial Analysis of Hotspots and Coldspots of Poverty ... 0305-750X(96)00071-XAdelheid Onyango, Katherine Tucker, Thomas Eisemon Household headship and child nutrition: A case ...
Tópico(s): Gender, Labor, and Family Dynamics
1986 - University of Chicago Press | Economic Development and Cultural Change
Hongbing Yang, Anuska Llano, Samandhy Cedeño, Annette von Delft, Angelica Corcuera, Geraldine M. Gillespie, Andrew Knox, Darren B. Leneghan, John Frater, Wolfgang Stöhr, Sarah Fidler, Beatriz Mothe, Johnson Mak, Christian Brander, Nicola Ternette, Lucy Dorrell, Eric Sandström, Janet Darbyshire, Frank A. Post, Christopher P. Conlon, Jane Anderson, Mala K. Maini, Timothy Peto, Peter Sasieni, Veronica Miller, Ian Weller, Sarah Fidler, John Frater, Abdel Babiker, Wolfgang Stöhr, Sarah Pett, Lucy Dorrell, Matthew Pace, Natalia Olejniczak, Helen Brown, Nicola Robinson, Jakub Kopycinski, Hongbing Yang, Tomáš Hanke, Alison Crook, Steven Kaye, Myra O. McClure, Otto Erlwein, Andrew Lovell, Maryam Khan, Michelle Gabrielle, Rachel Bennett, Aminata Sy, Adam Gregory, Fleur Hudson, Charlotte Russell, Gemma Wood, Hanna Box, Cherry Kingsley, Katie Topping, Andrew Lever, Mark R. Wills, Axel Fun, Mikaila Bandara, Damian J. Kelly, Simon Collins, Alex Markham, Mary Rauchenberger, Yinka Sowunmi, Shaadi Shidfar, Dominic Hague, Mark Nelson, Maddalena Cerrone, Nadia Castrillo Martinez, Tristan Barber, Alexandra Schoolmeesters, Christine Weaver, Orla Thunder, Jane Rowlands, Chris Higgs, Serge Fedele, Margherita Bracchi, Lervina Thomas, Peter Bourke, Nneka Nwokolo, Gaynor Lawrenson, Marzia Fiorino, Hinal Lukha, Sabine Kinloch-de Loës, Margaret M. Johnson, Alice Nightingale, Nnenna Ngwu, P. S. Byrne, Zoe Cuthbertson, Martin Jones, Tina Fernandez, Amanda Clarke, Martin Fisher, Rebecca Gleig, Vittorio Trevitt, Colin Fitzpatrick, Tanya Adams, Fiounnuala Finnerty, John Thornhill, Heather Lewis, Kristin Kuldanek, Julie Fox, Julianne Lwanga, Hiromi Uzu, Ming Lee, S Merle, Patrick O’Rourke, Isabel Jendrulek, T Flynn, Mark A. Taylor, Juan Tiraboschi, Tammy Murray,
Persistence of HIV through integration into host DNA in CD4+ T cells presents a major barrier to virus eradication. Viral integration may be curtailed when CD8+ T cells are triggered to kill infected CD4+ T cells through recognition of histocompatibility leukocyte antigen (HLA) class I-bound peptides derived from incoming virions. However, this has been reported only in individuals with "beneficial" HLA alleles that are associated with superior HIV control. Through interrogation of the pre-integration ...
Tópico(s): vaccines and immunoinformatics approaches
2021 - Cell Press | Cell Reports
Atara Ntekim, Omoba Temitayo Adeniji-Sofoluwe, Anthonia Sowunmi, Ayorinde Folasire, Olalekan Olasehinde, AbdulRazzak Lawaal, Thomas Olajide, Foluso Omodele, Omolara Fatiregun, Ayodele Sanni, Mustapha Ajani, Olayinka Kotila, Akinwunmi O. Komolafe, Alabi AO, P. Olaniyi, Chioma Asuzu, Adetola Daramola, Chinedum P. Babalola, Theodore Karrison, Olufunmilayo I. Olopade,
TPS622 Background: Breast cancer rates are increasing in Nigeria and across sub-Sahara Africa without the necessary infrastructure to manage the disease. Adequate clinical trial resources are needed to address the growing need for high quality, patient centered cancer care on the Continent. The ARETTA clinical trial was initiated by the Nigerian Breast Cancer Study Team in partnership with the University of Chicago Comprehensive Cancer Center. To build local capacity for biomarker informed clinical ...
Tópico(s): Advanced Breast Cancer Therapies
2022 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Weiwei Sun, Ce Gao, Gregory T. Gladkov, Isabelle Roseto, Leah Carrere, Elizabeth M. Parsons, Carmen Gasca‐Capote, John Frater, Sarah Fidler, Xu G. Yu, Mathias Lichterfeld, Eric Sandström, Janet Darbyshire, Frank A. Post, Christopher P. Conlon, Jane Anderson, Mala K. Maini, Timothy Peto, Peter Sasieni, Veronica Miller, Ian Weller, Sarah Fidler, John Frater, Abdel Babiker, Wolfgang Stöhr, Sarah Pett, Lucy Dorrell, Matthew Pace, Natalia Olejniczak, Helen Brown, Nicola Robinson, Jakub Kopycinski, Hongbing Yang, Tomáš Hanke, Alison Crook, S. Kaye, Myra O. McClure, Otto Erlwein, Andrew Lovell, Maryam Khan, Michelle Gabriel, Rachel Bennett, Aminata Sy, Andrew J. Gregory, Fleur Hudson, Charlotte Russell, Gemma Wood, Hanna Box, Cherry Kingsley, Katie Topping, Andrew Lever, Mark R. Wills, Axel Fun, Mikaila Bandara, Damian J. Kelly, Simon Collins, Alex Markham, Mary Rauchenberger, Yinka Sowunmi, Shaadi Shidfar, Dominic Hague, Sarah Fidler, Sarah Pett, Mark Nelson, Maddalena Cerrone, Nadia Castrillo Martinez, Tristan Barber, Alexandra Schoolmeesters, Christine Weaver, Orla Thunder, Jane Rowlands, Chris Higgs, Serge Fedele, Margherita Bracchi, Lervina Thomas, Peter Bourke, Nneka Nwokolo, Gaynor Lawrenson, Marzia Fiorino, Hinal Lukha, Sabine Kinloch, Margaret Johnson, Alice Nightingale, Nnenna Ngwu, P. S. Byrne, Zoe Cuthbertson, Martin Jones, Tina Fernandez, Aamanda Clarke, Martin Fisher, Rebecca Gleig, Vittorio Trevitt, Colin Fitzpatrick, Tanya Adams, Fionnuala Finnerty, John Thornhill, Heather Lewis, Kristin Kuldanek, Julie Fox, Julianne Lwanga, Hiromi Uzu, Ming Lee, S Merle, Patrick O’Rourke, Isabel Jendrulek, Taras ZarkoFlynn, Mark J. Taylor, Juan Tiraboschi, Tammy Murray,
Antiretroviral treatment (ART) initiation during the early stages of HIV-1 infection is associated with a higher probability of maintaining drug-free viral control during subsequent treatment interruptions, for reasons that remain unclear. Using samples from a randomized-controlled human clinical trial evaluating therapeutic HIV-1 vaccines, we here show that early ART commencement is frequently associated with accelerated and efficient selection of genome-intact HIV-1 proviruses in repressive chromatin ...
Tópico(s): Reproductive System and Pregnancy
2024 - Rockefeller University Press | The Journal of Experimental Medicine
Petra A. Burghaus, Klaus Lingelbach,
... Ref. 20Oduola A.M.J. Omitowoju G.O. Sowunmi A. Makler M.T. Falade C.O. Kyle ...
Tópico(s): Lipid Membrane Structure and Behavior
2001 - Elsevier BV | Journal of Biological Chemistry
Sarah Reagan-Steiner, Regina M. Simeone, Elizabeth L. Simon, Julu Bhatnagar, Titilope Oduyebo, Rebecca J. Free, Amy M. Denison, D. Brett Rabeneck, Sascha Ellington, Emily E. Petersen, Joy Gary, Gillian Hale, M. Kelly Keating, Roosecelis B. Martines, Atis Muehlenbachs, Jana M. Ritter, Ellen Lee, Alexander Davidson, Erin E. Conners, Sarah Scotland, Kayleigh Sandhu, Andrea Bingham, Elizabeth Kassens, Lou C. Smith, Kirsten St. George, Nina Ahmad, Mary R. Tanner, Suzanne F. Beavers, Brooke Miers, Kelley VanMaldeghem, Sumaiya Khan, Ingrid B. Rabe, Carolyn Gould, Dana Meaney‐Delman, Margaret A. Honein, Wun‐Ju Shieh, Denise J. Jamieson, Marc Fischer, Sherif R. Zaki, Melissa Kretschmer, Kara Tarter, Hayley D. Yaglom, Shoruq Alhajmohammad, Dildeep Chhabra, Wendy Jilek, Meghana Madala, Sharon Messenger, Charsey Cole Porse, María Salas, Diana Singh, Sarah Skallet, Similoluwa Sowunmi, Natalie S. Marzec, K. Justin Davis, Andrea Morrison, M. Zachariah Fraser, Colleen Ann O'Connor, Wendy M. Chung, Folasuyi Richardson, Meredith E. Stocks, Amanda Marie Bundek, Jennifer L. Zambri, A. Mark Allen, Marie Ketty Etienne, Jennifer Jackson, Vanessa Landis, Teresa C. Logue, Nicole Muse, Juliana Prieto, Mercedes Rojas, Amanda Feldpausch, Teri Graham, Sylvia Mann, Sarah Y. Park, Debbie Freeman, Emily Potts, Taryn Stevens, Sean Simonson, Julius Tonzel, Shari Davis, Sara Robinson, Judie Hyun, Erin Jenkins, Catherine Brown, Susan Soliva, Elizabeth Schiffman, Paul Byers, Sheryl Hand, Christine L. Mulgrew, Jeff Hamik, Samir Koirala, Elizabeth Ludwig, Carolyn Fredette, Abigail Mathewson, Kristin Garafalo, K. J. Worthington, Abubakar Ropri, Danielle Bloch, Sandhya Clark, Hannah Cooper, Annie D. Fine, Gili Hrusa, Martha Iwamoto, Hannah Kubinson, Christopher T. Lee, Sally Slavinski, Eliza Wilson, Ann Winters, David Yi Yang, Julius N. Ade, Zahra S. Alaali, Kimberly J. Alvarez, P. Bryon Backenson, Debra Blog, Amy B. Dean, Elizabeth Dufort, Andrea Marias Furuya, Meghan Fuschino, Rene Hull, Matthew Kleabonas, Karen E. Kulas, Philip Kurpiel, Lou Ann Lance, Emaly Leak, Ronald J. Limberger, Stephanie Ostrowski, MaryJo Polfleit, Amy McConkey Robbins, Jemma V. Rowlands, Inderbir Sohi, Jamie N. Sommer, Jennifer White, Dorothy J. Wiley, Li Zeng, Ronna L. Chan, Jennifer MacFarquhar, Laura Cronquist, Leah Lind, Kumar Nalluswami, Dana Perella, Diane Brady, Michael Gosciminski, Patricia McAuley, Bridget Teevan, Daniel Drociuk, Vinita Leedom, Brian Witrick, Jan Bollock, Lon Kightlinger, Marie Bottomley Hartel, Loraine Swanson Lucinski, Morgan McDonald, Angela M. Miller, Tori Armand Ponson, Laura Price, Kelly Broussard, Amy Nance, Dallin Peterson, Brennan Martin, Shea Elizabeth Browne, LaToya A. Griffin-Thomas, Jennifer Macdonald, Jillian Neary, Hanna N. Oltean, Alys Adamski, Madelyn A. Baez-Santiago, Brigid C. Bollweg, Janet D. Cragan, Yokabed Ermias, Lindsey Estetter, Shannon Fleck‐Derderian, Cynthia S. Goldsmith, Matthew R. Groenewold, Heather Hayes, Irogue Igbinosa, Tiffany Gayle Jenkinson, Abbey M. Jones, Amanda Lewis, Cynthia A. Moore, Kimberly Newsome, Vaunita Parihar, Mitesh Patel, Anna Paulino, Sonja A. Rasmussen, Meghan Raycraft, Megan R. Reynolds, Dominique Rollin, Jeanine H. Sanders, Carrie K. Shapiro‐Mendoza, Luciana Silva‐Flannery, Pamela Spivey, Alphonse K. Tshiwala, Tonya Williams, William A. Bower, Elizabeth Davlantes, Terra R. Forward, Rena Fukunaga, Jonas Z. Hines, Shaohua Sean Hu, Jessica Leung, Lillianne Lewis, Stacey W. Martin, Lucy A. McNamara, John D. Omura, Candice L. Robinson, Kristine M Schmit, Julie L. Self, Minesh Shah, Anne Straily, Elizabeth A. Van Dyne, Milan Vu, Charnetta Williams,
Zika virus infection during pregnancy can cause congenital microcephaly and brain abnormalities (1), and detection of Zika virus RNA in clinical and tissue specimens can provide definitive laboratory evidence of recent Zika virus infection. Whereas duration of viremia is typically short, prolonged detection of Zika virus RNA in placental, fetal, and neonatal brain tissue has been reported and can provide key diagnostic information by confirming recent Zika virus infection (2). In accordance with recent ...
Tópico(s): Viral Infections and Vectors
2017 - Centers for Disease Control and Prevention | MMWR Morbidity and Mortality Weekly Report