Eberhard Weihe, Sabine Müller, Thorsten Fink, H.J. Zentel,
By the use of light microscopic (LM) immunohistochemistry the distribution of tachykinin (TK)-, calcitonin gene-related peptide (CGRP)- and neuropeptide Y (NPY)-like immunoreactivity in nerves supplying the mammalian (rat, mouse, guinea-pig, cat) thymus gland has been determined. There were no interspecies variations. Fibres staining for TK and CGRP completely overlapped indicating coexistence. They were present in the capsule, in interlobular septa and in the corticomedullary boundary and occurred in ...
Tópico(s): Pain Mechanisms and Treatments
1989 - Elsevier BV | Neuroscience Letters
Thorsten Fink, Eberhard Weihe,
By the use of light microscopic (LM) immunohistochemistry, the presence of peptides and of dopamine β-hydroxylase (DBH) in nerves supplying mammalian (guinea pig, rat, cat, pig, mouse, human) lymph nodes were examined. In all species, lymph nodes of various somatic and visceral regions were found to contain nerve fibers which stained for neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP), peptide histidine isoleucine (PHI), substance P (SP), calcitonin gene-related peptide (CGRP) or DBH, SP-and ...
Tópico(s): Cancer, Stress, Anesthesia, and Immune Response
1988 - Elsevier BV | Neuroscience Letters
Eberhard Weihe, Donatus Nöhr, Sabine Michel, Sabine Müller, H.J. Zentel, Thorsten Fink, J. Krekel,
Light microscopic immunohistochemistry was employed to elucidate and compare the presence, distribution, and coexistence of various peptides, neuroendocrine markers and enzymes of the catecholamine pathway in nerves supplying lymphoid tissues in a variety of mammalian species. All lymphoid organs and tissues receive innervation by fibers containing dopamine-beta-hydroxylase and/or tyrosine hydroxylase, neural markers like protein gene product 9.5, synaptophysin and neurofilament and a varied spectrum ...
Tópico(s): Receptor Mechanisms and Signaling
1991 - Taylor & Francis | International Journal of Neuroscience
Horacio E. Romeo, Thorsten Fink, Noboru Yanaihara, Eberhard Weihe,
Tópico(s): Cardiovascular, Neuropeptides, and Oxidative Stress Research
1994 - Elsevier BV | Peptides
Dieter Hörsch, Thorsten Fink, Burkhard Göke, Rudolf Arnold, Markus W. Büchler, Eberhard Weihe,
The presence, morphology and distribution of anal neuroendocrine cells were investigated with a panel of antisera and antibodies for neural markers, biogenic amines, and neuropeptides by the sensitive streptavidin-biotin-peroxidase immunocytochemistry, and coexistence patterns of neurochemically characterized neuroendocrine cells were examined by double immunofluorescence cytochemistry. In the colorectal zone, endocrine-like cells were immunoreactive for chromogranin A (CGA), serotonin (5-HT), pancreastatin ( ...
Tópico(s): Peptidase Inhibition and Analysis
1994 - Elsevier BV | Regulatory Peptides
Thorsten Fink, Pierluigi Di Sebastiano, Mathias B chler, H. G. Beger, Eberhard Weihe,
Growth-associated protein-43, an established marker of neuronal plasticity during development and in injury, was used to characterize innervation in the normal human pancreas and changes in chronic alcohol-induced pancreatitis by using light microscopic immunocytochemistry and computer-assisted image analysis. Immunostaining for the pan-neuronal marker protein gene-product 9.5 served as a reference for the characterization of total innervation in both groups. In normal human pancreas, strong protein ...
Tópico(s): Nerve injury and regeneration
1994 - Elsevier BV | Neuroscience
Pierluigi Di Sebastiano, Thorsten Fink, Eberhard Weihe, Helmut Friess, Hans G. Beger, Markus W. Büchler,
Tópico(s): Pediatric Pain Management Techniques
1995 - Springer Science+Business Media | Digestive Diseases and Sciences
Bernhard Dietzschold, Wilhelm Schwaeble, Martin K.H. Schäfer, D. Craig Hooper, Young Mu Zehng, Franz Petry, Hai Sheng, Thorsten Fink, Michael Loos, Hilary Koprowski, Eberhard Weihe,
In situ hybridization, RT-PCR and Northern blot analysis as well immunohistochemistry were used to examine the expression of C1q, a subcomponent of the rat complement system, in brains of rats infected with Borna disease virus (BDV) and rats afflicted with experimental allergic encephalomyelitis (EAE) induced by the adoptive transfer of myelin basic protein specific T cells. C1q mRNA, which was not detected in normal brain, became clearly detectable using RT-PCR analysis by d14 post infection (p.i.) ...
Tópico(s): Mosquito-borne diseases and control
1995 - Elsevier BV | Journal of the Neurological Sciences
E. Schulze, Martin Witt, Thorsten Fink, Andreas Höfer, Richard H. W. Funk,
Tópico(s): Pain Mechanisms and Treatments
1997 - Elsevier BV | Acta Histochemica
Pierluigi Di Sebastiano, Thorsten Fink, Eberhard Weihe, Helmut Frieß, Paolo Innocenti, H. G. Beger, MW Büchler,
mechanisms underlying the generation and perpetuation
Tópico(s): Fibroblast Growth Factor Research
1997 - Elsevier BV | Gastroenterology
A.D. Ansselin, Thorsten Fink, D. F. Davey,
This study tested the usefulness of Schwann cells in the repair of a severed nerve with a biosynthetic bridge or guide. Reinforced collagen nerve guides were used to bridge an 18 mm gap in the sciatic nerve of 21 young adult rats. The animals were divided into three groups and the guides were filled with: (i) more than 0.5 x 10(6) cultured syngeneic adult Schwann cells (group L, n = 12); (ii) less than 0.5 x 10(6) Schwann cells (Group S, n = 6); and (iii) phosphate buffered saline (control, n = 3). Schwann ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
1997 - Wiley | Neuropathology and Applied Neurobiology
Pierluigi Di Sebastiano, Thorsten Fink, Fabio F. di Mola, Eberhard Weihe, Paolo Innocenti, Helmut Frieß, Markus W. Büchler,
Summary Background 15–25% of appendices removed from patients with suspected appendicitis appear normal on histological examination. The cause of pain in such patients is unknown. Since the content of neuropeptides seems to be altered in chronic inflammation, we investigated possible changes in peptidergic innervation for substance P (SP), vasoactive intestinal peptide (VIP), and growth-associated protein-43 (GAP-43). Methods Appendices classified as showing acute appendicitis, non-acute appendicitis (clinical ...
Tópico(s): Intestinal and Peritoneal Adhesions
1999 - Elsevier BV | The Lancet
Thorsten Fink, D. F. Davey, A.D. Ansselin,
We have investigated the responsiveness of adult guinea pig Schwann cells to a range of neuroligands, using ratiometric calcium imaging. The majority of cells responded to ATP (90 ± 4%), adrenaline (57 ± 5%), and noradrenaline (61 ± 5%), as well as glutamate (60 ± 5%). The number of cells responding to glutamate increased significantly (90 ± 4%; p < 0.01) when the cells were grown in excitatory amino acid (EAA) free medium, indicating EAA-induced downregulation. Only a small number of cells (9 ± 2%) responded to acetylcholine. ...
Tópico(s): Receptor Mechanisms and Signaling
1999 - NRC Research Press | Canadian Journal of Physiology and Pharmacology
Dieter Hörsch, Thorsten Fink, Markus W. Büchler, Eberhard Weihe,
Abstract Despite the pivotal clinical significance of the human anal canal, little is known about its total and specific innervation. This study assessed the comparative distribution and histotopology of nerve fibres immunoreactive for neural markers and a variey of regulatory active neuropeptides in the human anal canal by light microscopic immunohistochemistry. Depending on the epithelial zone and region of the anal canal, the neural elements were differentially immunoreactive for the pan‐neural ...
Tópico(s): Ion Channels and Receptors
1993 - Wiley | The Journal of Comparative Neurology
Thorsten Fink, Jens‐Peter Kreiß,
In this paper, we deal with autoregressive processes with random coefficients. We propose a least‐squares estimator for the fourth‐order moments of both the innovation and disturbance noises and state its consistency. The main theme of the paper is the development of bootstrap procedures for the autoregressive parameter. We show how to obtain approximative residuals for the process even though the standard method for autoregressive processes does not work in this context since one then would obtain ...
Tópico(s): Control Systems and Identification
2013 - Wiley | Journal of Time Series Analysis
Dat Nguyen, Steven C. DeFina, William H. Fink, Thorsten Dieckmann,
RNA plays a central role in many biological processes and is therefore an important target for drug development. In recent years an increasing wealth of structural and functional information about RNA−ligand complexes has been obtained using in vitro selected RNAs (aptamers). However, all those studies focused on structure and changes of the nucleic acid and mostly considered the ligand as a rigid target. To develop a detailed picture of ligand structure and dynamics in RNA−small molecule complexes, ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2002 - American Chemical Society | Journal of the American Chemical Society
Lukas M. Müller‐Wirtz, Felix Maurer, Timo Brausch, Daniel Kiefer, Maximilian Alexander Floss, Jonas Doneit, Thomas Volk, Daniel I. Sessler, Tobias Fink, Thorsten Lehr, Sascha Kreuer,
Background: Propofol can be measured in exhaled gas. Exhaled and plasma propofol concentrations correlate well, but the relationship with tissue concentrations remains unknown. We thus evaluated the relationship between exhaled, plasma, and various tissue propofol concentrations. Because the drug acts in the brain, we focused on the relationship between exhaled and brain tissue propofol concentrations. METHODS: Thirty-six male Sprague-Dawley rats were anesthetized with propofol, ketamine, and rocuronium ...
Tópico(s): Receptor Mechanisms and Signaling
2020 - Lippincott Williams & Wilkins | Anesthesia & Analgesia
Donatus Nöhr, Sabine Michel, Thorsten Fink, Eberhard Weihe,
Tópico(s): Pharmacological Receptor Mechanisms and Effects
1995 - Springer Science+Business Media | Cell and Tissue Research
Thorsten R. C. Johnson, Christian Fink, Stefan O. Schönberg, Maximilian F. Reiser,
Dual-energy CT is a novel, rapidly emerging imaging technique which offers important new functional and specific information. In this book, physicists and specialists from different CT manufacturers p
Tópico(s): Radiation Dose and Imaging
2010 - Springer Nature | Medical radiology
Eberhard Weihe, Thorsten Fink, Sabine Müller,
Tópico(s): Pharmacological Receptor Mechanisms and Effects
1988 - Elsevier BV | Regulatory Peptides
Thomas Bosch, O. Heinemann, C. Duhr, Thorsten Wendler, C. Keller, Edwin Fink, TILLMANN KIRSCHNER, S. Klebert, W. Samtleben,
Abstract: Direct adsorption of lipoproteins (DALI) is the first lipid apheresis system compatible with whole blood with the advantage of a very simple procedure. A mixture of heparin plus citrate (ACD‐A) is used for the anticoagulation regimen (AR). A clinical, prospective, controlled crossover study was performed to test the safety and efficacy of low‐dose citrate (LDC) anticoagulation in DALI. Five chronic DALI patients suffering from coronary heart disease and hypercholesterolemia underwent 3 DALI ...
Tópico(s): Venous Thromboembolism Diagnosis and Management
2000 - Wiley | Artificial Organs
Thorsten Zenz, Raymonde Busch, Anna Maria Fink, Dirk Winkler, Kirsten Fischer, Andreas Bühler, Patrick Hoth, Günter Fingerle‐Rowson, Michael Kneba, Sebastian Böettcher, Ulrich Jäger, Myriam Mendila, Michael Wenger, Peter Lichter, Michael Hallek, Hartmut Döhner, Stephan Stilgenbauer,
Abstract Abstract 2427 Introduction: The introduction of chemo-immunotherapy (R-FC) has led to impressive improvement of response, PFS and remarkably overall survival in CLL. Irrespective of these improvements, the genetic markers remain important predictors of outcome. With increasing intensity of 1st line treatment, the proportion of patients with refractory disease is decreasing. At the same time the selective pressure on tumor cells increases. Relatively little is known about the genetic profile ...
Tópico(s): Lymphoma Diagnosis and Treatment
2010 - Elsevier BV | Blood
Thorsten Plewan, Ralph Weidner, Gereon R. Fink,
Tópico(s): Multisensory perception and integration
2012 - Springer Science+Business Media | Experimental Brain Research
Dat Nguyen, Thorsten Dieckmann, Michael E. Colvin, William H. Fink,
RNA plays a central role in many biological processes and is therefore an important target for drug development. In recent years an increasing wealth of structural and functional information about RNA−ligand complexes has been obtained using in vitro selected RNAs (aptamers). However, all those studies focused on structure and changes of the nucleic acid and mostly considered the ligand as a rigid target. Experimental characterization of the dynamics of a malachite green (MAG)−RNA aptamer complex ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2003 - American Chemical Society | The Journal of Physical Chemistry B
Thorsten R. C. Johnson, Konstantin Nikolaou, Christian Fink, Alexander Becker, Andreas Knez, C. Rist, M Reiser, Christoph R. Becker,
Tópico(s): Medical Imaging Techniques and Applications
2007 - Springer Science+Business Media | Der Radiologe
Sabine Müller, Thorsten Fink, Eberhard Weihe,
Tópico(s): Neuropeptides and Animal Physiology
1988 - Elsevier BV | Regulatory Peptides
The medico-legal assessment of a subdural haematoma (recent or organized) usually requires some information regarding its cause. Quite often, especially in the absence of a known history of trauma, minor head injuries, which are no longer verifiable, are simply assumed to be the most likely causes. Considering the fact that a subdural haematoma could also be non-traumatic, e.g. in haemorrhagic disorders, cardiac conditions with persistent passive hyperaemia, true inflammatory and degenerative processes ...
Tópico(s): Child Abuse and Related Trauma
2000 - Elsevier BV | Forensic Science International
Nefertiti El-Nikhely, Annika Karger, Poonam Sarode, Indrabahadur Singh, Andreas Weigert, Astrid Wietelmann, Thorsten Stiewe, Reinhard Dammann, Ludger Fink, Friedrich Grimminger, Guillermo Barreto, Werner Seeger, Soni Savai Pullamsetti, Ulf R. Rapp, Rajkumar Savai,
Abstract Although NF-κB is known to play a pivotal role in lung cancer, contributing to tumor growth, microenvironmental changes, and metastasis, the epigenetic regulation of NF-κB in tumor context is largely unknown. Here we report that the IKK2/NF-κB signaling pathway modulates metastasis-associated protein 2 (MTA2), a component of the nucleosome remodeling and deacetylase complex (NuRD). In triple transgenic mice, downregulation of IKK2 (Sftpc-cRaf-IKK2DN) in cRaf-induced tumors in alveolar epithelial ...
Tópico(s): Peptidase Inhibition and Analysis
2020 - American Association for Cancer Research | Cancer Research
G.‐Andre Banat, Aleksandra Tretyn, Soni Savai Pullamsetti, Jochen Wilhelm, Andreas Weigert, Catherine Olesch, Katharina Ebel, Thorsten Stiewe, Friedrich Grimminger, Werner Seeger, Ludger Fink, Rajkumar Savai,
Recent studies indicate that the abnormal microenvironment of tumors may play a critical role in carcinogenesis, including lung cancer. We comprehensively assessed the number of stromal cells, especially immune/inflammatory cells, in lung cancer and evaluated their infiltration in cancers of different stages, types and metastatic characteristics potential. Immunohistochemical analysis of lung cancer tissue arrays containing normal and lung cancer sections was performed. This analysis was combined ...
Tópico(s): Immunotherapy and Immune Responses
2015 - Public Library of Science | PLoS ONE
Sebastian Böttcher, Matthias Ritgen, Kirsten Fischer, Stephan Stilgenbauer, Raymonde M. Busch, Günter Fingerle‐Rowson, Anna Maria Fink, Andreas Bühler, Thorsten Zenz, Michael Wenger, Myriam Mendila, Clemens‐Martin Wendtner, Barbara Eichhorst, Hartmut Döhner, Michael Hallek, Michael Kneba,
Purpose To determine the clinical significance of flow cytometric minimal residual disease (MRD) quantification in chronic lymphocytic leukemia (CLL) in addition to pretherapeutic risk factors and to compare the prognostic impact of MRD between the arms of the German CLL Study Group CLL8 trial. Patients and Methods MRD levels were prospectively quantified in 1,775 blood and bone marrow samples from 493 patients randomly assigned to receive fludarabine and cyclophosphamide (FC) or FC plus rituximab ( ...
Tópico(s): Immunodeficiency and Autoimmune Disorders
2012 - Lippincott Williams & Wilkins | Journal of Clinical Oncology