Produção Nacional
Revisado por pares
Tiago Cardoso da Costa-Lima, Leandro Delalibera Geremias, José Roberto Postali Parra,
A pesquisa teve como objetivo estudar a influência da temperatura e da umidade relativa do ar (UR) no desenvolvimento de Liriomyza sativae Blanchard, durante o período ovo-adulto, em feijão caupi, para fornecer subsídios a futuros projetos de controle biológico da praga. Verificou-se uma relação inversa entre o aumento da temperatura na faixa de 15°C a 32°C e a duração do desenvolvimento. A sobrevivência larval não foi afetada na faixa térmica estudada, enquanto a 32°C houve alta mortalidade de pupas ( ...
Tópico(s): Agronomic Practices and Intercropping Systems
2009 - Springer Nature | Neotropical Entomology
Luís M. Camarinha-Matos, Hamideh Afsarmanesh, Ersin C. Kaletas, Tiago Cardoso,
The practical implantation of the concept of dynamic virtual enterprise is still far from expectations due to a number of factors such as the lack of appropriate interoperable infrastructures and tools, lack of common ontology, and the socio-organizational difficulties. However, the creation of industry clusters supported by advanced information and communication tools can meanwhile provide a basis for the rapid creation of dynamic virtual enterprises in response to the market opportunities. A federated ...
Tópico(s): Service-Oriented Architecture and Web Services
2002 - Springer Science+Business Media | IFIP advances in information and communication technology
Produção Nacional
Revisado por pares
Nívia da Silva Dias, José Roberto Postali Parra, Tiago Cardoso da Costa-Lima,
O objetivo deste trabalho foi avaliar as características biológicas dos parasitóides Trichogrammatoidea annulata, Trichogramma atopovirilia e Trichogramma bruni, criados em hospedeiros alternativos durante diferentes gerações, para selecionar o melhor hospedeiro para a criação massal desses parasitóides. O experimento foi conduzido em delineamento inteiramente ao acaso, em esquema fatorial 3x3 (três hospedeiros - Anagasta kuehniella, Corcyra cephalonica e Sitotroga cerealella - e três gerações - 1ª, 10ª ...
Tópico(s): Insect behavior and control techniques
2008 - Embrapa Informação Tecnológica | Pesquisa Agropecuária Brasileira
Produção Nacional
Revisado por pares
Tiago Cardoso da Costa-Lima, Leandro Delalibera Geremias, José Roberto Postali Parra,
We studied a population of Liriomyza sativae Blanchard (Diptera: Agromyzidae) identified by morphological and molecular techniques from the semiarid region of the Brazilian northeast. The influence of temperature and relative humidity on the survival and reproductive parameters of L. sativae in cowpeas (Vigna unguiculata L. Walp.) (Fabales: Fabaceae) was evaluated. We used temperatures of 18, 20, 22, 25, 28, 30, and 32 ± 1°C (50 ± 10% RH) and relative humidity values of 30, 50, 70, and 90 ± 10% (25 ± 1°C) under ...
Tópico(s): Agronomic Practices and Intercropping Systems
2010 - Oxford University Press | Environmental Entomology
Tiago Cardoso da Fonseca, Paula Relógio, J. M. G. Martinho, José Paulo S. Farinha,
We prepared water dispersions of poly(n-butyl methacrylate-st-butyl acrylate) crosslinked core-shell nanoparticles functionalized with different amounts of trimethoxisilane (TMS) groups in the outer shell. The purpose of the TMS groups is to chemically bind the rubbery particles to a nanostructured silica network, using sol-gel copolymerization. Here, we present nanoparticles containing 13 mol % and 30 mol % of TMS groups in the outer shell and compare their surface morphology with particles that do ...
Tópico(s): Nanofabrication and Lithography Techniques
2007 - American Chemical Society | Langmuir
João Gameiro, Tiago Cardoso, Yves Rybarczyk,
The sign language is widely used by deaf people around the globe. As the spoken languages, several sign languages do exist. The way sign language is learned by deaf people may have some details to be improved, but one can state that the existing learning mechanisms are effective when we talk about a deaf child, for example. The problem arises for the non-deaf persons that communicate with the deaf persons – the so-called listeners. If, for example, one couple has a new child that turns to be deaf, ...
Tópico(s): Tactile and Sensory Interactions
2014 - Elsevier BV | Procedia Technology
João Gameiro, Tiago Cardoso, Yves Rybarczyk,
Sign language is the hearing impaired form of communicating with other people, including listeners. Most cases, impaired people have learned sign language form childhood. The problem arises when a listener comes in contact with an impaired person. For instances, if a couple has a child which is impaired, the parents find a challenge to learn the sign language. In this article, a new playful approach to assist the listeners to learn sign language is proposed. This proposal is a serious game composed ...
Tópico(s): Tactile and Sensory Interactions
2014 - Springer Science+Business Media | IFIP advances in information and communication technology
Produção Nacional
Revisado por pares
Lane Coelho Viana, Camila Mendes de Lima, Marcus Augusto‐Oliveira, Rubilene Pinheiro Borges, Tiago Cardoso, Izabela Almeida, Daniel Guerreiro Diniz, João Bento‐Torres, Antônio Pereira, Manuella Batista‐de‐Oliveira, Allan Lopes, Rosângela Figueiredo Mendes-da-Silva, Ricardo Abadie‐Guedes, Ângela Amâncio dos Santos, Denise Sandrelly Cavalcanti de Lima, Pedro Fernando da Costa Vasconcelos, Colm Cunningham, Rubem Carlos Araújo Guedes, Cristovam Wanderley Picanço Diniz,
It has been demonstrated that rat litter size affects the immune cell response, but it is not known whether the long-term effects aggravate age-related memory impairments or microglial-associated changes. To that end, we raised sedentary Wistar rats that were first suckled in small or large litters (6 or 12 pups/dam, respectively), then separated into groups of 2–3 rats from the 21st post-natal day to study end. At 4 months (young adult) or 23 months (aged), all individual rats were submitted to spatial ...
Tópico(s): Stress Responses and Cortisol
2013 - Elsevier BV | Neuroscience
Pedro Martins, Joaquim Tiago Cardoso Leles de Jesus, Sofia Nascimento dos Santos, Luís R. Raposo, Catarina Roma‐Rodrigues, Pedro V. Baptista, Alexandra R. Fernandes,
The majority of heterocycle compounds and typically common heterocycle fragments present in most pharmaceuticals currently marketed, alongside with their intrinsic versatility and unique physicochemical properties, have poised them as true cornerstones of medicinal chemistry. Apart from the already marketed drugs, there are many other being investigated for their promising activity against several malignancies. In particular, anticancer research has been capitalizing on the intrinsic versatility ...
Tópico(s): Synthesis of Tetrazole Derivatives
2015 - Multidisciplinary Digital Publishing Institute | Molecules
Shane Grealish, Andreas Heuer, Tiago Cardoso, Agnete Kirkeby, Marie E. Jönsson, Jenny K. Johansson, Anders Björklund, Johan Jakobsson, Malin Parmar,
Human embryonic stem cell (hESC)-derived dopamine neurons are currently moving toward clinical use for Parkinson's disease (PD). However, the timing and extent at which stem cell-derived neurons functionally integrate into existing host neural circuitry after transplantation remain largely unknown. In this study, we use modified rabies virus to trace afferent and efferent connectivity of transplanted hESC-derived neurons in a rat model of PD and report that grafted human neurons integrate into the ...
Tópico(s): Nerve injury and regeneration
2015 - Elsevier BV | Stem Cell Reports
Olof Torper, Daniella Rylander Ottosson, Maria Pereira, Shong Lau, Tiago Cardoso, Shane Grealish, Malin Parmar,
The possibility of directly converting non-neuronal cells into neurons in situ in the brain would open therapeutic avenues aimed at repairing the brain after injury or degenerative disease. We have developed an adeno-associated virus (AAV)-based reporter system that allows selective GFP labeling of reprogrammed neurons. In this system, GFP is turned on only in reprogrammed neurons where it is stable and maintained for long time periods, allowing for histological and functional characterization of ...
Tópico(s): CRISPR and Genetic Engineering
2015 - Cell Press | Cell Reports
Cyril Corbet, Adán Pinto, Ruben Martherus, Joaquim Tiago Cardoso Leles de Jesus, Florence Polet, Olivier Féron,
Bioenergetic preferences of cancer cells foster tumor acidosis that in turn leads to dramatic reduction in glycolysis and glucose-derived acetyl-coenzyme A (acetyl-CoA). Here, we show that the main source of this critical two-carbon intermediate becomes fatty acid (FA) oxidation in acidic pH-adapted cancer cells. FA-derived acetyl-CoA not only fuels the tricarboxylic acid (TCA) cycle and supports tumor cell respiration under acidosis, but also contributes to non-enzymatic mitochondrial protein hyperacetylation, ...
Tópico(s): Metabolomics and Mass Spectrometry Studies
2016 - Cell Press | Cell Metabolism
Alexandra R. Fernandes, Joaquim Tiago Cardoso Leles de Jesus, Pedro Martins, Sara Figueiredo, Daniela Rosa, Luísa M. D. R. S. Martins, M. Luísa Corvo, Manuela Carvalheiro, Pedro M. Costa, Pedro V. Baptista,
Due to their small size and unique properties, multifunctional nanoparticles arise as versatile delivery systems easily grafted with a vast array of functional moieties, such as anticancer cytotoxic chemotherapeutics and targeting agents. Here, we formulated a multifunctional gold-nanoparticle (AuNP) system composed of a monoclonal antibody against epidermal growth factor receptor (EGFR) (anti-EGFR D-11) for active targeting and a Co(II) coordination compound [CoCl(H2O)(phendione)2][BF4] (phendione=1, ...
Tópico(s): Gold and Silver Nanoparticles Synthesis and Applications
2016 - Elsevier BV | Journal of Controlled Release
Agnete Kirkeby, Sara Nolbrant, Katarína Tiklová, Andreas Heuer, Nigel Kee, Tiago Cardoso, Daniella Rylander Ottosson, Mariah J. Lelos, Pedro Rifes, Stephen B. Dunnett, Shane Grealish, Thomas Perlmann, Malin Parmar,
Stem cell treatments for neurodegenerative diseases are expected to reach clinical trials soon. Most of the approaches currently under development involve transplantation of immature progenitors that subsequently undergo phenotypic and functional maturation in vivo, and predicting the long-term graft outcome already at the progenitor stage remains a challenge. Here, we took an unbiased approach to identify predictive markers expressed in dopamine neuron progenitors that correlate with graft outcome ...
Tópico(s): Animal Genetics and Reproduction
2016 - Elsevier BV | Cell stem cell
Luís M. Camarinha-Matos, Tiago Cardoso,
Electronic procurement of partners is an important functionality during the life cycle of a virtual enterprise. A prototype implementation, featuring selection based on both internal or Internet-based suppliers' directories, is discussed. The generation of call for tenders and support for management of received bids is introduced and directions for contract negotiation and decision support system are discussed.
Tópico(s): Collaboration in agile enterprises
1999 - Springer Science+Business Media | IFIP advances in information and communication technology
Daniela Lehnen, Serena Barral, Tiago Cardoso, Shane Grealish, Andreas Heuer, Andrej Smiyakin, Agnete Kirkeby, Jutta Kollet, Harold Cremer, Malin Parmar, Andreas Bosio, Sebastian Knöbel,
Human pluripotent stem cell (hPSC)-derived mesencephalic dopaminergic (mesDA) neurons can relieve motor deficits in animal models of Parkinson's disease (PD). Clinical translation of differentiation protocols requires standardization of production procedures, and surface-marker-based cell sorting is considered instrumental for reproducible generation of defined cell products. Here, we demonstrate that integrin-associated protein (IAP) is a cell surface marker suitable for enrichment of hPSC-derived ...
Tópico(s): Virus-based gene therapy research
2017 - Elsevier BV | Stem Cell Reports
Tiago Cardoso, Andrew F. Adler, Bengt Mattsson, Deirdre B. Hoban, Sara Nolbrant, Jenny Nelander Wahlestedt, Agnete Kirkeby, Shane Grealish, Anders Björklund, Malin Parmar,
Dopamine (DA) neurons derived from human embryonic stem cells (hESCs) are a promising unlimited source of cells for cell replacement therapy in Parkinson's disease (PD). A number of studies have demonstrated functionality of DA neurons originating from hESCs when grafted to the striatum of rodent and non-human primate models of PD. However, several questions remain in regard to their axonal outgrowth potential and capacity to integrate into host circuitry. Here, ventral midbrain (VM) patterned hESC- ...
Tópico(s): Neurological disorders and treatments
2018 - Wiley | The Journal of Comparative Neurology
Produção Nacional
Revisado por pares
Talita Antonia da Silveira, Patricia Sanches, Luiza Cristiane Fialho Zazycki, Tiago Cardoso da Costa-Lima, Fernando Cabezas Guerrero, Arodí P. Favaris, Henrique Fonseca Goulart, José Maurício S. Bento, Antônio Euzébio Goulart Santana,
Emission of herbivore-induced plant volatiles (HIPVs) can differ according to the type of herbivory and the plant development stage, ultimately affecting recruitment of the natural enemy. Little is known about plant defenses induced at the flowering stage by phloem-feeding insects. We investigated the olfactory preference of Encarsia desantisi parasitoids and the chemical profile of flowering melon plants induced or not by the phloem-feeding of Bemisia tabaci whiteflies. In addition, we tested whether ...
Tópico(s): Plant and animal studies
2018 - Springer Science+Business Media | Arthropod-Plant Interactions
Marcus Davidsson, Gang Wang, Patrick Aldrin-Kirk, Tiago Cardoso, Sara Nolbrant, Morgan Hartnor, Janitha Mudannayake, Malin Parmar, Tomas Björklund,
Adeno-associated virus (AAV) capsid modification enables the generation of recombinant vectors with tailored properties and tropism. Most approaches to date depend on random screening, enrichment, and serendipity. The approach explored here, called BRAVE (barcoded rational AAV vector evolution), enables efficient selection of engineered capsid structures on a large scale using only a single screening round in vivo. The approach stands in contrast to previous methods that require multiple generations ...
Tópico(s): Viral Infections and Immunology Research
2019 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Diogo Oliveira, André M. Machado, Tiago Cardoso, Mónica Lopes‐Marques, L. Filipe C. Castro, Raquel Ruivo,
Nucleobase-Ascorbate Transporter (NAT) family includes ascorbic acid, nucleobases, and uric acid transporters: With broad evolutionary distribution. In vertebrates, four members have been previously recognized, the ascorbate transporters Slc23a1 and Slc3a2, the nucleobase transporter Slc23a4 and an orphan transporter Slc23a3. Using phylogenetic and synteny analysis, we identify a fifth member of the vertebrate slc23 complement (slc23a5), present in neopterygians (gars and teleosts) and amphibians, ...
Tópico(s): Physiological and biochemical adaptations
2019 - Multidisciplinary Digital Publishing Institute | Fishes
Andrew F. Adler, Tiago Cardoso, Sara Nolbrant, Bengt Mattsson, Deirdre B. Hoban, Ulla Jarl, Jenny Nelander Wahlestedt, Shane Grealish, Anders Björklund, Malin Parmar,
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2019 - Cell Press | Cell Reports
Katarína Tiklová, Sara Nolbrant, Alessandro Fiorenzano, Åsa K. Björklund, Yogita Sharma, Andreas Heuer, Linda Gillberg, Deirdre B. Hoban, Tiago Cardoso, Andrew F. Adler, Marcella Birtele, Hilda Lundén-Miguel, Nikolaos Volakakis, Agnete Kirkeby, Thomas Perlmann, Malin Parmar,
Abstract Cell replacement is a long-standing and realistic goal for the treatment of Parkinsonʼs disease (PD). Cells for transplantation can be obtained from fetal brain tissue or from stem cells. However, after transplantation, dopamine (DA) neurons are seen to be a minor component of grafts, and it has remained difficult to determine the identity of other cell types. Here, we report analysis by single-cell RNA sequencing (scRNA-seq) combined with comprehensive histological analyses to characterize ...
Tópico(s): Single-cell and spatial transcriptomics
2020 - Nature Portfolio | Nature Communications
Cyril Corbet, Estelle Bastien, Joaquim Tiago Cardoso Leles de Jesus, Emeline Dierge, Ruben Martherus, Catherine Vander Linden, Bastien Doix, Charline Degavre, Céline Guilbaud, Laurenne Petit, Carine Michiels, Chantal Dessy, Yvan Larondelle, Olivier Féron,
Acidosis, a common characteristic of the tumor microenvironment, is associated with alterations in metabolic preferences of cancer cells and progression of the disease. Here we identify the TGF-β2 isoform at the interface between these observations. We document that acidic pH promotes autocrine TGF-β2 signaling, which in turn favors the formation of lipid droplets (LD) that represent energy stores readily available to support anoikis resistance and cancer cell invasiveness. We find that, in cancer ...
Tópico(s): Liver physiology and pathology
2020 - Nature Portfolio | Nature Communications
Deirdre B. Hoban, Shelby Shrigley, Bengt Mattsson, Ludivine S. Breger, Ulla Jarl, Tiago Cardoso, Jenny Nelander Wahlestedt, Kelvin C. Luk, Anders Björklund, Malin Parmar,
Preclinical assessment of the therapeutic potential of dopamine (DA) neuron replacement in Parkinson’s disease (PD) has primarily been performed in the 6-hydroxydopamine toxin model. While this is a good model to assess graft function, it does not reflect the pathological features or progressive nature of the disease. In this study, we establish a humanized transplantation model of PD that better recapitulates the main disease features, obtained by coinjection of preformed human α-synuclein (α-syn) ...
Tópico(s): Nerve injury and regeneration
2020 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Produção Nacional
Revisado por pares
Andréa Costa Oliveira, Tiago Cardoso da Costa-Lima, A. V. de Souza, Rita de Cássia Rodrigues Gonçalves Gervásio,
ABSTRACT Liriomyza sativae (Blanchard) is a worldwide polyphagous pest for horticultural and ornamental crops, whose chemical control is the major method adopted. However, botanical insecticides in the form of essential oils (EOs) are presented as promising alternatives. This study aimed to evaluate the effect of EOs from the species Croton sonderianus Muell. Arg., Croton conduplicatus Kunth., Lippia gracilis Schauer and Lippia schaueriana Mart. on the biological aspects of L. sativae adults and immature ...
Tópico(s): Insect behavior and control techniques
2020 - UNIVERSIDADE FEDERAL DE GOIÁS | Pesquisa Agropecuária Tropical
Agnete Kirkeby, Jenny Nelander, Deirdre B. Hoban, Nina Rogelius, Hjálmar Bjartmarz, Petter Storm, Alessandro Fiorenzano, Andrew F. Adler, Shelby Vale, Janitha Mudannayake, Yu Zhang, Tiago Cardoso, Bengt Mattsson, Anne M. Landau, Andreas Nørgaard Glud, Jens Sörensen, Thea P. Lillethorup, Mark W. Lowdell, Carla Carvalho, Owen Bain, Trinette van Vliet, Olle Lindvall, Anders Björklund, Bronwen Harry, Emma Cutting, Håkan Widner, Gesine Paul, Roger A. Barker, Malin Parmar,
Cell replacement therapies for Parkinson's disease (PD) based on transplantation of pluripotent stem cell-derived dopaminergic neurons are now entering clinical trials. Here, we present quality, safety, and efficacy data supporting the first-in-human STEM-PD phase I/IIa clinical trial along with the trial design. The STEM-PD product was manufactured under GMP and quality tested in vitro and in vivo to meet regulatory requirements. Importantly, no adverse effects were observed upon testing of the ...
Tópico(s): Mesenchymal stem cell research
2023 - Elsevier BV | Cell stem cell
Produção Nacional
Revisado por pares
Guilherme Franz, Carlos Alberto Eiras Garcia, Janini Pereira, Luiz Paulo de Freitas Assad, Marcelo Rollnic, Luis Hamilton Pospissil Garbossa, Letícia Cotrim da Cunha, Carlos A. D. Lentini, Paulo Nobre, Alexander Turra, Janice R. Trotte-Duhá, Mauro Cirano, Segen F. Estefen, José Antônio Moreira Lima, Afonso M. Paiva, Maurício Almeida Noernberg, C. A. S. Tanajura, José L. Moutinho, Francisco Campuzano, Ella S. Pereira, André Cunha Lima, Luís Felipe Ferreira de Mendonça, Helder Nocko, Leandro Machado, João Bosco Rodrigues Alvarenga, Renato Parkinson Martins, Carina Stefoni Böck, Raquel Toste, Luiz Landau, Tiago Cardoso de Miranda, Francisco dos Santos, Júlio Augusto de Castro Pellegrini, Manuela Juliano, Ramiro Neves, Andrei Polejack,
Coastal ocean observing and modeling systems (coastal observatories), connected with regional and global ocean systems, improve the quality of information and forecasts for effective management of safe and sustainable maritime activities. The public availability of systematic and long-term information of the ocean is an engine for the Blue Economy, boosting economic growth, employment, and innovation. An overview of some Brazilian initiatives is presented in this paper, involving universities, private ...
Tópico(s): Marine and coastal ecosystems
2021 - Frontiers Media | Frontiers in Marine Science
Produção Nacional
Revisado por pares
Henrique V. da Silva, Celso K. Morooka, Ivan Rizzo Guilherme, Tiago Cardoso da Fonseca, José Ricardo Pelaquim Mendes,
A methodology for pipeline leakage detection using a combination of clustering and classification tools for fault detection is presented here. A fuzzy system is used to classify the running mode and identify the operational and process transients. The relationship between these transients and the mass balance deviation are discussed. This strategy allows for better identification of the leakage because the thresholds are adjusted by the fuzzy system as a function of the running mode and the classified ...
Tópico(s): Advanced Chemical Sensor Technologies
2005 - Elsevier BV | Journal of Petroleum Science and Engineering
Tiago Cardoso, João Ricardo Ferreira Delgado, José Barata,
Human-Computer-Interaction (HCI) is a key topic on the Accessibility area, namely in what concerns a Smart-City environment, where humans have to interact with artefacts spread all around one particular city. In the last decade HCI has experienced a significant evolution towards a desired fully natural user interface, for example in what concerns the ability to recognize a wide range of hand gestures in real-time. Some efforts have lately been made in the hardware sector in order to deploy sensors ...
Tópico(s): Human Pose and Action Recognition
2015 - Elsevier BV | Procedia Computer Science
Produção Nacional
Revisado por pares
Marina Medici Loureiro Subtil, Dominiqui Costa Goes, Tiago Cardoso Gomes, Mariane Lima de Souza,
INTRODUÇÃO: A relação estabelecida entre fisioterapeuta e paciente é um aspecto fundamental do processo de adesão no tratamento fisioterapêutico e neste estudo foi definida como um processo multifatorial. OBJETIVOS: Investigar a relação entre o fenômeno da adesão na fisioterapia e as características do relacionamento estabelecido entre fisioterapeutas e pacientes. METODOLOGIA: Estudo qualitativo e exploratório, com delineamento ex-post facto, amostra por conveniência de 11 pacientes de 25 a 73 anos ...
Tópico(s): Psychotherapy Techniques and Applications
2011 - PONTIFÍCIA UNIVERSIDADE CATÓLICA DO PARANÁ | Fisioterapia em Movimento