Produção Nacional
Revisado por pares
J. Boone Kauffman, Virni Budi Arifanti, Ângelo F. Bernardino, Tiago Osório Ferreira, Daniel Murdiyarso, Miguel Cifuentes, Jennifer Norfolk,
... for more papers by this authorTiago O Ferreira, Tiago O Ferreira Soil Science Department, Luiz de Queiroz College of ... for more papers by this authorTiago O Ferreira, Tiago O Ferreira Soil Science Department, Luiz de Queiroz College of ...
Tópico(s): Peatlands and Wetlands Ecology
2018 - Wiley | Frontiers in Ecology and the Environment
Pedro Brites, Ana S. Ferreira, Tiago Ferreira da Silva, Vera Sousa, Ana Rita Malheiro, Marinus Durán, Hans R. Waterham, Myriam Baes, Ronald J. A. Wanders,
A deficiency of plasmalogens, caused by impaired peroxisomal metabolism affects normal development and multiple organs in adulthood. Treatment options aimed at restoring plasmalogen levels may be relevant for the therapy of peroxisomal and non-peroxisomal disorders. In this study we determined the in vivo efficacy of an alkyl glycerol (AG), namely, 1-O-octadecyl-rac-glycerol, as a therapeutic agent for defects in plasmalogen synthesis. To achieve this, Pex7 knockout mice, a mouse model for Rhizomelic ...
Tópico(s): Metabolism and Genetic Disorders
2011 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Janaína Karin Lima Campos, Chrisjacele Santos Ferreira de Araujo, Tiago Ferreira da Silva Araújo, Andréa F. S. Santos, J. A. Teixeira, Vera Lúcia de Menezes Lima, Luana Cassandra Breitenbach Barroso Coelho,
A galactose-specific lectin from Bauhinia monandra leaves (BmoLL) has been purified through ammonium sulfate fractionation followed by guar gel affinity chromatography column. This study aimed to evaluate the potential anti-inflammatory and antinociceptive activity of pure BmoLL in mice. Anti-inflammatory activity was evaluated by 1% carrageenan-induced inflammation in mice treated with BmoLL. Acetic acid-induced abdominal writhing and hot plate methods evaluated antinociceptive activity. BmoLL significantly ...
Tópico(s): Pharmacological Effects of Natural Compounds
2016 - Elsevier BV | Biochimie Open
Bruna Carbas, Daniela Simões, Andreia Soares, Andreia Freitas, Bruno Ferreira, Alexandre R. F. Carvalho, A. Sanches‐Silva, Tiago Ferreira Pinto, Eugénio Diogo, Eugénia de Andrade, Carla Brites,
Maize is an important worldwide commodity susceptible to fungal contamination in the field, at harvest, and during storage. This work aimed to determine the occurrence of Fusarium spp. in maize grains produced in the Tagus Valley region of Portugal and the levels of related mycotoxins in the 2018 harvest and during their storage for six months in barrels, mimicking silos conditions. Continuous monitoring of temperature, CO2, and relative humidity levels were done, as well as the concentration of ...
Tópico(s): Indoor Air Quality and Microbial Exposure
2021 - Multidisciplinary Digital Publishing Institute | Foods
Daniel Castro, Filipa Ferreira, Inês Castro, Ana Rita Rodrigues, Marta Correia, Josefina Ribeiro, Tiago Ferreira,
The network model of psychopathology suggests that central and bridge symptoms are promising treatment targets because they may accelerate the dissolution of the network of interactions between the symptoms of mental disorders. However, there is no sound theoretical foundation for centrality measures in psychopathological networks and some of them are unstable. The construct of bridge symptoms also lacks a clear definition and diverse conceptualizations coexist in the literature associated with ...
Tópico(s): Treatment of Major Depression
2019 - Frontiers Media | Frontiers in Psychology
Amit Kulkarni, Tiago Ferreira, Clemens Bretscher, Annabel Grewenig, Nazim El‐Andaloussi, Serena Bonifati, Tiina Marttila, Valérie Palissot, Jubayer A. Hossain, Francisco Azuaje, Hrvoje Miletić, Lars Ystaas, Anna Golebiewska, Simone P. Niclou, Ralf Roeth, Beate Niesler, Amélie Weiss, Laurent Brino, Antonio Marchini,
Abstract H-1 parvovirus (H-1PV) is a promising anticancer therapy. However, in-depth understanding of its life cycle, including the host cell factors needed for infectivity and oncolysis, is lacking. This understanding may guide the rational design of combination strategies, aid development of more effective viruses, and help identify biomarkers of susceptibility to H-1PV treatment. To identify the host cell factors involved, we carry out siRNA library screening using a druggable genome library. ...
Tópico(s): Animal Virus Infections Studies
2021 - Nature Portfolio | Nature Communications
Assia L. Angelova, Tiago Ferreira, Clemens Bretscher, Jean Rommelaere, Antonio Marchini,
Resistance to anticancer treatments poses continuing challenges to oncology researchers and clinicians. The underlying mechanisms are complex and multifactorial. However, the immunologically “cold” tumor microenvironment (TME) has recently emerged as one of the critical players in cancer progression and therapeutic resistance. Therefore, TME modulation through induction of an immunological switch towards inflammation (“warming up”) is among the leading approaches in modern oncology. Oncolytic viruses ( ...
Tópico(s): Virus-based gene therapy research
2021 - Multidisciplinary Digital Publishing Institute | Cancers
Xiang Ji, Tiago Ferreira, Beth Friedman, Rui Liu, Hannah Liechty, Erhan Bas, Jayaram Chandrashekar, David Kleinfeld,
The microvasculature underlies the supply networks that support neuronal activity within heterogeneous brain regions. What are common versus heterogeneous aspects of the connectivity, density, and orientation of capillary networks? To address this, we imaged, reconstructed, and analyzed the microvasculature connectome in whole adult mice brains with sub-micrometer resolution. Graph analysis revealed common network topology across the brain that leads to a shared structural robustness against the ...
Tópico(s): Advanced Neuroimaging Techniques and Applications
2021 - Cell Press | Neuron
Rita Silva‐Reis, Ana I. Faustino‐Rocha, Mariana Gonçalves, Catarina Castro-Ribeiro, Tiago Ferreira, Carla M. Ribeiro-Silva, Lio Gonçalves, L. Antunes, Carlos Venâncio, Rita Ferreira, Adelina Gama, Paula A. Oliveira,
This study aimed to define appropriate humane endpoints (HEs) for an animal model of colorectal carcinogenesis (CRC). Twenty-nine male Wistar rats were divided into two control groups (CTRL1 and CTRL2) injected with ethylenediamine tetraacetic acid (EDTA)–saline solutions and two induced groups (CRC1 and CRC2) injected with 1,2-dimethylhydrazine (DMH) for seven weeks. A score sheet with 14 biological parameters was used to assess animal welfare. Groups CRC1 and CTRL1 and groups CRC2 and CTRL2 were euthanized ...
Tópico(s): Dietary Effects on Health
2021 - Multidisciplinary Digital Publishing Institute | Animals
Rita Pinto‐Costa, Sara Sousa, Sérgio Carvalho Leite, Joana Nogueira‐Rodrigues, Tiago Ferreira da Silva, Diana Machado, Joana M. Marques, Ana Catarina Costa, Márcia A. Liz, Francesca Bartolini, Pedro Brites, Mercedes Costell, Reinhard Fässler, Mónica Mendes Sousa,
After trauma, regeneration of adult CNS axons is abortive, causing devastating neurologic deficits. Despite progress in rehabilitative care, there is no effective treatment that stimulates axonal growth following injury. Using models with different regenerative capacities, followed by gain- and loss-of-function analysis, we identified profilin 1 (Pfn1) as a coordinator of actin and microtubules (MTs), powering axonal growth and regeneration. In growth cones, Pfn1 increased actin retrograde flow, MT ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2020 - American Society for Clinical Investigation | Journal of Clinical Investigation
Tiago Ferreira, Christian Geiser, Joana Cadima, Marisa Matias, Teresa Leal, Paula Mena Matos,
This study examined the factorial, convergent, and discriminant validity of scores on the Strengths and Difficulties Questionnaire (SDQ), a tool for screening children's psychological adjustment.Data were collected from a community sample of 346 children (46% girls, M age ϭ 54.07 months), using teacher, mother, and father reports.Results from confirmatory factor analyses indicated that the SDQ's hypothesized 5-factor structure fit the data well and partial strict measurement invariance was established ...
Tópico(s): Early Childhood Education and Development
2020 - American Psychological Association | Psychological Assessment
Riccardo Giacomo Kranzusch, Fabian aus dem Siepen, Stephanie Wiesemann, Leonora Zange, Sarah Jeuthe, Tiago Ferreira da Silva, Titus Küehne, Burkert Pieske, Christoph Tillmanns, Matthias G. Friedrich, Jeanette Schulz‐Menger, Daniel Messroghli,
T1 mapping using modified Look-Locker inversion recovery (MOLLI) provides quantitative information on myocardial tissue composition. T1 results differ between sites due to variations in hardware and software equipment, limiting the comparability of results. The aim was to test if Z-scores can be used to compare the results of MOLLI T1 mapping from different cardiovascular magnetic resonance (CMR) platforms. First, healthy subjects (n = 15) underwent 11 combinations of native short-axis T1 mapping (four ...
Tópico(s): Amyloidosis: Diagnosis, Treatment, Outcomes
2020 - BioMed Central | Journal of Cardiovascular Magnetic Resonance
Tiago Ferreira, Adelina Gama, Fernanda Seixas, Ana I. Faustino‐Rocha, Carlos Lopes, Vítor M. Gaspar, João F. Mano, Rui Medeiros, Paula A. Oliveira,
Breast cancer is one of the most common and well-known types of cancer among women worldwide and is the most frequent neoplasm in intact female dogs. Female dogs are considered attractive models or studying spontaneous breast cancer, whereas female rats are currently the most widely used animal models for breast cancer research in the laboratory context. Both female dogs and female rats have contributed to the advancement of scientific knowledge in this field, and, in a “One Health” approach, they ...
Tópico(s): Hedgehog Signaling Pathway Studies
2023 - Multidisciplinary Digital Publishing Institute | Veterinary Sciences
Tânia Martins, Catarina Castro-Ribeiro, Sílvia Lemos, Tiago Ferreira, Elisabete Nascimento-Gonçalves, Eduardo Rosa, Paula A. Oliveira, L. Antunes,
Obesity, classified as an epidemic by the WHO, is a disease that continues to grow worldwide. Obesity results from abnormal or excessive accumulation of fat and usually leads to the development of other associated diseases, such as type 2 diabetes, hypertension, cancer, cardiovascular diseases, among others. In vitro and in vivo models have been crucial for studying the underlying mechanisms of obesity, discovering new therapeutic targets, and developing and validating new pharmacological therapies ...
Tópico(s): Adipose Tissue and Metabolism
2022 - Multidisciplinary Digital Publishing Institute | Obesities
Cameron Arshadi, Ulrik Günther, Mark Eddison, Kyle Harrington, Tiago Ferreira,
SNT is an end-to-end framework for neuronal morphometry and whole-brain connectomics that supports tracing, proof-editing, visualization, quantification and modeling of neuroanatomy. With an open architecture, a large user base, community-based documentation, support for complex imagery and several model organisms, SNT is a flexible resource for the broad neuroscience community. SNT is both a desktop application and multi-language scripting library, and it is available through the Fiji distribution ...
Tópico(s): Genetics, Bioinformatics, and Biomedical Research
2021 - Nature Portfolio | Nature Methods
Produção Nacional
Revisado por pares
Thaíse Gabriele da Silva Brito, Ana Paula Sant’Anna da Silva, Rebeca Xavier da Cunha, Caíque Silveira Martins da Fonseca, Tiago Ferreira da Silva Araújo, Janaína Karin de Lima Campos, Weber Melo Nascimento, Hallysson Douglas Andrade de Araújo, Joanda Paolla Raimundo e Silva, Josean Fechine Tavares, Bianka Santana dos Santos, Vera Lúcia de Menezes Lima,
Plinia cauliflora (Mart.) Kausel, known in Brazil as jabuticaba or jaboticaba has been used by Brazilian native populations for medicinal purposes, including those related to inflammatory conditions, such as asthma, diarrhea, disorders in female genitourinary tract, and tonsillitis. Inflammation has emerged as a main factor for the oxidative stress, hyperglycemia, and dyslipidemia present in chronic noncommunicable diseases (NCDs). Such disturbances have been a leading cause of death worldwide for ...
Tópico(s): Phytochemistry Medicinal Plant Applications
2020 - Elsevier BV | Journal of Ethnopharmacology
Tânia Brandão, Marisa Matias, Tiago Ferreira, Joana Vieira, Marc S. Schulz, Paula Mena Matos,
Abstract Objective There is a well‐established link in the literature between secure romantic attachment orientation and psychological well‐being. The underlying processes of this link and the couple interplay between attachment and well‐being are notably less explored. Using a dyadic framework, this study examines both couple members' emotion regulation strategies as potential mediators of this link. Method One hundred and nineteen heterosexual couples completed self‐report measures on attachment ...
Tópico(s): Family Dynamics and Relationships
2019 - Wiley | Journal of Personality
Ana Rita Malheiro, Bárbara Regadas Correia, Tiago Ferreira da Silva, Diogo Bessa‐Neto, Paul P. Van Veldhoven, Pedro Brites,
Abstract Plasmalogens are the most abundant form of ether phospholipids in myelin and their deficiency causes Rhizomelic Chondrodysplasia Punctata (RCDP), a severe developmental disorder. Using the Gnpat ‐knockout (KO) mouse as a model of RCDP, we determined the consequences of a plasmalogen deficiency during myelination and myelin homeostasis in the central nervous system (CNS). We unraveled that the lack of plasmalogens causes a generalized hypomyelination in several CNS regions including the optic ...
Tópico(s): Bone and Joint Diseases
2019 - Wiley | Brain Pathology
Michael N. Economo, Johan Winnubst, Erhan Bas, Tiago Ferreira, Jayaram Chandrashekar,
Abstract Reconstruction of the axonal projection patterns of single neurons has been an important tool for understanding both the diversity of cell types in the brain and the logic of information flow between brain regions. Innovative approaches now enable the complete reconstruction of axonal projection patterns of individual neurons with vastly increased throughput. Here, we review how advances in genetic, imaging, and computational techniques have been exploited for axonal reconstruction. We ...
Tópico(s): Single-cell and spatial transcriptomics
2019 - Wiley | The Journal of Comparative Neurology
Produção Nacional
Revisado por pares
Leôncio Lopes Soares, Filipe Rios Drummond, Leonardo Mateus Teixeira de Rezende, Alexandre Costa, Tiago Ferreira Leal, Meilene Ribeiro Fidélis, Mariana Machado‐Neves, Thales Nicolau Prímola‐Gomes, Miguel Araújo Carneiro‐Júnior, Emily Correna Carlo Reis, Antônio José Natali,
Analyze the effects of voluntary running during the development of pulmonary arterial hypertension (PAH) induced by monocrotaline (MCT) on the right ventricle (RV) structure, RV myocyte contractility and intracellular Ca2+ transient in rats with MCT-induced PAH.Male Wistar rats were housed sedentary or with free access to a running wheel after MCT or saline injection for until HF or median end-point day of HF in sedentary animals (24 days). Echocardiographic examination and exercise tolerance test were ...
Tópico(s): Cardiovascular Function and Risk Factors
2019 - Elsevier BV | Life Sciences
Tiago Ferreira, Marlene Sousa Silva, João Salgado,
Background: The lack of knowledge regarding psychometric characteristics of brief scales for assessing the severity of symptoms of depression for the Portuguese population limits the ability of health professionals to signal clinically relevant situations, as well as the implementation of alternative forms of mental health care. The Patient Health Questionnaire (PHQ-9) is a scale whose usefulness in various professional contexts has been amply demonstrated by research. However, some of its psychometric ...
Tópico(s): Workplace Health and Well-being
2019 - | The Psychologist Practice & Research Journal
Produção Nacional
Revisado por pares
Renata Oliveira Samuel, Edílson Ervolino, Índia Olinta de Azevedo Queiroz, Mariane Maffei Azuma, Gabriela Tiago Ferreira, Luciano Tavares Ângelo Cintra,
Abstract Introduction The aim of this study was to evaluate the inflammatory profile of T helper (Th) cells in normoglycemic (N) and diabetic rats with apical periodontitis (AP). Methods Twenty male Wistar rats were divided in 2 groups: N rats and rats with diabetes mellitus (DM). DM was induced using streptozotocin, and AP was induced by dental pulp exposure of the first mandibular molar to the oral environment. After 30 days, the mandibles were removed and processed for histologic analysis, bacterial analysis, ...
Tópico(s): S100 Proteins and Annexins
2019 - Elsevier BV | Journal of Endodontics
Johan Winnubst, Erhan Bas, Tiago Ferreira, Zhuhao Wu, Michael N. Economo, Patrick Edson, Benjamin Arthur, Christopher M. Bruns, Konrad Rokicki, David Schauder, Donald J. Olbris, Sean D. Murphy, David Ackerman, Cameron Arshadi, Perry Baldwin, Regina Blake, Ahmad Elsayed, Mashtura Hasan, Daniel Ramirez, Bruno Dos Santos, Monet Weldon, Amina Zafar, Joshua T. Dudman, Charles R. Gerfen, Adam W. Hantman, Wyatt Korff, Scott M. Sternson, Nelson Spruston, Karel Svoboda, Jayaram Chandrashekar,
Neuronal cell types are the nodes of neural circuits that determine the flow of information within the brain. Neuronal morphology, especially the shape of the axonal arbor, provides an essential descriptor of cell type and reveals how individual neurons route their output across the brain. Despite the importance of morphology, few projection neurons in the mouse brain have been reconstructed in their entirety. Here we present a robust and efficient platform for imaging and reconstructing complete ...
Tópico(s): Neural dynamics and brain function
2019 - Cell Press | Cell
Laura Hulea, Simon‐Pierre Gravel, Masahiro Morita, Marie Cargnello, Oro Uchenunu, Young Kyuen Im, Camille Lehuédé, H. Eric, Matthew Leibovitch, Shannon McLaughlan, Marie‐José Blouin, Maxime Parisotto, Vasilios Papavasiliou, Cynthia Lavoie, Ola Larsson, Michael Ohh, Tiago Ferreira, Celia M.T. Greenwood, Gaëlle Bridon, Daina Avizonis, Gerardo Ferbeyre, Peter M. Siegel, Russell G. Jones, William J. Muller, Josie Ursini‐Siegel, Julie St‐Pierre, Michaël Pollak, Ivan Topisirović,
There is increasing interest in therapeutically exploiting metabolic differences between normal and cancer cells. We show that kinase inhibitors (KIs) and biguanides synergistically and selectively target a variety of cancer cells. Synthesis of non-essential amino acids (NEAAs) aspartate, asparagine, and serine, as well as glutamine metabolism, are major determinants of the efficacy of KI/biguanide combinations. The mTORC1/4E-BP axis regulates aspartate, asparagine, and serine synthesis by modulating ...
Tópico(s): Metabolism, Diabetes, and Cancer
2018 - Cell Press | Cell Metabolism
Produção Nacional
Revisado por pares
Joel Alves Rodrigues, Thales Nicolau Prímola‐Gomes, Leôncio Lopes Soares, Tiago Ferreira Leal, Clara Nóbrega, Danillo Laviola Pedrosa, Leonardo Mateus Teixeira de Rezende, Edilamar Menezes de Oliveira, Antônio José Natali,
Background: Regulation of intracellular calcium (Ca2+) in cardiomyocytes is altered by hypertension; and aerobic exercise brings benefits to hypertensive individuals. Objective: To verify the effects of aerobic exercise training on contractility and intracellular calcium (Ca2+) transients of cardiomyocytes and on the expression of microRNA 214 (miR-214) in the left ventricle of spontaneously hypertensive rats (SHR). Methods: SHR and normotensive Wistar rats of 16 weeks were divided into 4 groups -sedentary ...
Tópico(s): Adipose Tissue and Metabolism
2018 - Sociedade Brasileira de Cardiologia (SBC) | Arquivos Brasileiros de Cardiologia
Joana Cadima, Sílvia Barros, Tiago Ferreira, Marina Serra-Lemos, Teresa Leal, Karine Verschueren,
In the present study, we examine the bidirectional associations between child vocabulary and self-regulation and their interplay with two relational dimensions, teacher–child closeness and autonomy support in preschool. Participants were 208 young children (50% boys; M = 4 years and 11 months, SD = 0.71) from socially disadvantaged areas in Portugal. Self-regulation and vocabulary were assessed at the beginning and end of the year. Teachers reported on levels of teacher–child closeness and autonomy support. ...
Tópico(s): Parental Involvement in Education
2018 - Elsevier BV | Early Childhood Research Quarterly
Marisa Matias, Tiago Ferreira, Joana Vieira, Joana Cadima, Teresa Leal, Paula Mena Matos,
Workplace family support has been regarded as a factor that helps reduce individuals' work to family conflict (WFC). How this support translates into families' functioning is still to be determined. In this study, we used a systems perspective to examine (a) how perceptions of workplace family support affect parental satisfaction and consequently reduce WFC and (b) how the perception of support affects partners' parental satisfaction and WFC in dual‐earner couples. A two‐wave dyadic data set of dual‐ ...
Tópico(s): Family Dynamics and Relationships
2017 - Wiley | Applied Psychology
Marisa Matias, Tiago Ferreira, Joana Vieira, Joana Cadima, Teresa Leal, Paula Mena Matos,
Abstract Work–family balance and child rearing are major social concerns. Few studies, however, have addressed how parents' work–family conflict ( WFC ) associates with children's emotion regulation. This study proposes the link to occur through parents' psychological availability ( PA ). In our model we tested both intraindividual and interindividual effects on a sample of 138 dual‐earner couples with preschool‐aged children. Our results showed that WFC related negatively to PA (actor and partner effects); ...
Tópico(s): Emotional Labor in Professions
2017 - Wiley | Personal Relationships
Tiago Ferreira, Joana Cadima, Marisa Matias, Joana Marina Vieira, Teresa Leal, Karine Verschueren, Paula Mena Matos,
Parental engagement in positive activities with the child may show significant variation across time, assuming a crucial influence on child development.In dual-earner families, work-family conflict can interfere with parental engagement, with negative consequences for children's behavior.The current study examined the change trajectories of mothers' and fathers' engagement in early childhood, analyzing whether these trajectories are influenced by parents' work-family conflict and whether they predict ...
Tópico(s): Child and Adolescent Psychosocial and Emotional Development
2017 - American Psychological Association | Developmental Psychology
Joana Vieira, Marisa Matias, Tiago Ferreira, Frederick G. Lopez, Paula Mena Matos,
Studies on the impact of work-family dynamics on both parenting and children's outcomes are scarce. The present study addressed this gap by exploring how parents' negative (conflicting) and positive (enriching) experiencing of work and family roles related to children's internalizing and externalizing problem behaviors through its association with the quality of parent-child relationships. A sample of 317 dual-earner couples with preschool children was used to conduct a dyadic analysis of both within- ...
Tópico(s): Gender, Labor, and Family Dynamics
2016 - American Psychological Association | Journal of Family Psychology