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Miscellaneous Free eBooks

Artigo

O Albrechtsen,

... omdanne det i fibrinet tilstedeværende fibrinolytiske proenzym, plasminogen, til det aktive fibrinolytiske enzym plasmin. En række væv ... er for størstedelen ukendt. Man har imidlertid kendskab til tilstedeværelsen af en lavmolekylær plasmininhibitor (pulmin) i okselungevæv ... væv. Dette skyldes ikke mindst vævsaktivatorens stærke binding til vævsproteinerne. En gennemgang af tidligere analytiske metoder har ... for det foreliggende arbejde at udarbejde en analysemetode til kvantitativ bestemmelse af vævenes indhold af plasminogen aktivatorer. ...

Tópico(s): Bone and Dental Protein Studies

1959 - Wiley | Acta Physiologica Scandinavica

Artigo Revisado por pares

Jeannine Alexander, Patricia Rayman, Mark Edinger, Robert W. Connelly, Raymond Tubbs, Ronald M. Bukowski, Edson Pontes, James H. Finke,

Abstract TIL were cultured from human renal‐cell carcinoma (RCC) in 1,000 U/ml rIL2 and restimulated with ... Greater cell yields resulted from multiple restimulations of TIL with autologous tumor. In most instances, these TIL lysed autologous tumor better than TIL grown in rIL2 alone. Enhanced proliferation was seen also after restimulation of TIL with allogeneic RCC as well as with tumor ... 50 U/ml rIL2 were successful in expanding TIL with enhanced lytic activity; however, this activity was ... for autologous tumor. The phenotype of the tumorrestimulated TIL generally did not change. In most of the ...

Tópico(s): Immune cells in cancer

1990 - Wiley | International Journal of Cancer

Livro

Project Gutenberg

Artigo Acesso aberto Revisado por pares

R B Cameron, Paul J. Spiess, S A Rosenberg,

The adoptive transfer of tumor-infiltrating lymphocytes (TIL) with the concomitant administration of IL-2 has been shown to mediate the regression of established 6- and 14-d murine hepatic and pulmonary metastases. For successful immunotherapy with TIL, however, pretreatment with either cyclophosphamide (CP) or whole ... exact mechanism of CP and WBX augmentation of TIL antitumor activity remains unknown, but the elimination of ... if local tumor irradiation (LTX) could synergize with TIL as well as WBX, we investigated the effect ...

Tópico(s): Cancer Immunotherapy and Biomarkers

1990 - Rockefeller University Press | The Journal of Experimental Medicine

Artigo Acesso aberto Revisado por pares

Suzanne L. Topalian, A Kasid, S A Rosenberg,

... tumor-specific agents such as tumor infiltrating lymphocytes (TIL) are employed for cancer therapy. To examine this ... highly specific oligoclonal MHC class I-restricted cytolytic TIL grown in bulk culture from patient 397 were used to immunoselect a TIL-resistant variant tumor from the autologous cultured melanoma ... 397-R4, a variant completely resistant to 397 TIL but not to allogeneic LAK cell lysis in ... Failure of 397-R4 to cold target inhibit TIL lysis of 397-mel suggested that cell-surface modification was at least one mechanism causing TIL resistance. The inherent lysability of 397-R4 was ...

Tópico(s): Cancer Immunotherapy and Biomarkers

1990 - American Association of Immunologists | The Journal of Immunology

Artigo Revisado por pares

Maurizio Viale, Silvano Ferrini, Salvatore Serrano, Davide Serrano, Andrea Ardizzoni, A Nicolin,

Tumor infiltrating (TIL) and peripheral blood lymphocytes (PBL) were isolated from 18 patients with non-small cell lung cancer undergoing radical surgery. Surface marker analysis revealed that TILs and PBLs mainly consisted of CD3+ T cells and that TILs generally displayed a lower CD4/CD8 ratio. Differences ... MHC class II) antigens, which were increased in TILs, and in the percentage of CD16+ natural killer (NK) cells, which was reduced in TILs as compared to PBLs. Accordingly, the NK activity of TILs was lower than that of PBLs, whereas neither ...

Tópico(s): Cancer Immunotherapy and Biomarkers

1990 - SAGE Publishing | Tumori Journal

Primary Document Acesso aberto

Mogensen, Carl, Muhle, Carl Adolf,

"Efter et noget gammelt manuscript befordret til trykken ved Carl Adolph Muhle." Errata at end of text. Book.

0000 - Gale Group | The Making of Modern World

Artigo Acesso aberto Revisado por pares

A Kasid, Shoshana Morecki, Paul Aebersold, Kenneth Cornetta, Kenneth W. Culver, Sally Freeman, E P Director, Michael T. Lotze, R. Michael Blaese, W. French Anderson,

Tumor-infiltrating lymphocytes (TILs) are cells generated from tumor suspensions cultured in interleukin 2 that can mediate cancer regression when adoptively transferred into mice or humans. Since TILs proliferate rapidly in vitro, recirculate, and preferentially localize ... man. To determine whether efficient gene transfer into TILs is feasible, we transduced human TILs with the bacterial gene for neomycin-resistance (NeoR) using the retroviral vector N2. The transduced TIL populations were stable and polyclonal with respect to ...

Tópico(s): Cancer Research and Treatments

1990 - National Academy of Sciences | Proceedings of the National Academy of Sciences

Livro

OAPEN Free

Revisão Revisado por pares

Inger Storli,

... monuments. Sammendrag Artikkelen er ei omarbeida prøveforeles‐ning til magistergradseksamen i arkeologi ved Universitetet i Tromsø høsten ... et resultat av en prosess som først tok til i områdene rundt Finskebukta i tida rundt Kr. ... har i nokså liten grad reist spørsmål knytta til den kulturelle dualismen i Nord‐Norge. Ottars beretning ... islandske sagalitteraturen har leda både arkeologer og historikere til å hevde at norrøn høvdingmakt i jernalderen i ... befolk‐ningsgruppene bar preg av samarbeid og likeverd til langt ut i middelalderen. Ifølge Odner indikerer nemlig ...

Tópico(s): Folklore, Mythology, and Literature Studies

1986 - Routledge | Acta Borealia

Artigo Revisado por pares

Ragnhild Høgsæt,

... En har lenge ment at en av grunnene til at den norske staten ble svekket i seinmiddelalderen, ... som for en begrenset økonomisk godtgjørelse var villige til å opptre som kongens representanter. Men i seinmiddelalderen ... bøndenes, og de var ikke lenger i stand til å låne kongemakta lokal autoritet. Dette betydde en ... statens. Kirka hadde større organisatoriske muligheter enn kongen til å tilpasse seg nedgangen i folketallet. Kirkas inntekter ... ei rekke kirkelige avgifter som indirekte var knyttet til folketallet. Men kirka økte andelen sin av jordegodset. ...

Tópico(s): Historical and Archaeological Studies

1986 - Routledge | Acta Borealia

Primary Document Acesso aberto

Risell, Jöns, Lewenhaupt, Charles Emil, greve, Chydenius, Anders,

At head of title: Imprimatur. N. v. Oelreich. Caption title. Signed: Jöns Risell, advocat fiscal wid Kongl. Bergs-collegium. A pamphlet of this title ...

0000 - Gale Group | The Making of Modern World

Artigo Revisado por pares

Roger Jørgensen,

... artikkel presenteres en oversikt over noen funnkategorier datert til perioden. Artikkelen pretenderer ikke å gi en uttømmede ... og førromersk jernalder. Denne ekspansjon ser imidlertid ut til i hovedsak å være begrenset til Nordland og Troms hvor det i perioden sannsynligvis ... åkerbruk og fehold ser i liten grad ut til å ha berørt Finnmark hvor jakt/fangst‐økonomi i all overveiende grad ser ut til å ha vært dominerende. Det kronologiske avsnitt som ... samt endringer i det arkeologiske materialet ved overgangen til romertid, avgrenser den til bronsealder og førromersk jernalder, ...

Tópico(s): Metallurgy and Cultural Artifacts

1986 - Routledge | Acta Borealia

Primary Document Acesso aberto

Pflueg, Christian Carl,

Attributed to Carl Christian Pflueg by Kress Library. Signed: X. Kress Library identifies Z as Friedrich Buchwald. Book.

0000 - Gale Group | The Making of Modern World

Artigo Acesso aberto Revisado por pares

Sylvia Miescher, Theresa L. Whiteside, S Carrel, V von Fliedner,

Tumor-infiltrating lymphocytes (TIL) were obtained from 22 humans with solid tumors. In three cases only, one colon and two lung carcinomas, TIL which contained from 3 to 10% of T ... the presence of exogenous IL 2. In most TIL preparations, however, the T lymphocytes did not express ... proliferate in response to IL 2. In contrast, TIL were able to proliferate in response to irradiated ... PBL were not inhibited by the addition of TIL. In most tumors, the TIL showed no response or had significantly lower (p ...

Tópico(s): Immune cells in cancer

1986 - American Association of Immunologists | The Journal of Immunology