Attributed to Nils Lilliecreutz--Cf. NUC pre-1956. Book.
0000 - Gale Group | The Making of Modern World
Marte C. Liefaard, Anna van der Voort, Maartje van Seijen, Bram Thijssen, Joyce Sanders, Shiva Vonk, Lorenza Mittempergher, Rajith Bhaskaran, Linda de Munck, A. Elise van Leeuwen‐Stok, Roberto Salgado, Hugo M. Horlings, Esther H. Lips, Gabe S. Sonke,
Abstract Tumor-infiltrating lymphocytes (TILs) have been associated with outcomes in HER2-positive breast cancer patients treated with neoadjuvant chemotherapy and trastuzumab. However, it remains unclear if TILs could be a prognostic and/or predictive biomarker ... In this study, we evaluated the association between TILs and pathological response (pCR) and invasive-disease free ... trial. Although no significant association was seen between TILs and pCR, patients with TIL scores ≥60% demonstrated an excellent 3-year IDFS ...
Tópico(s): Cancer Cells and Metastasis
2024 - Nature Portfolio | npj Breast Cancer
National Bureau of Economic Research (NBER)
Bech, F. J. (Frederik Julius),
Book.
0000 - Gale Group | The Making of Modern World
Maolei Xu, Weilan Zhong, Chen Yang, Ming Liu, Xiaoqing Yuan, Tao Lu, Desheng Li, Guanqing Zhang, Huan Liu, Yuying Zeng, Xiaoping Yang, Yufu Zhou, Ling Zhou,
Tiliroside (TIL) is a flavonoid compound that exists in a variety of edible plants. These dietary plants are widely ... to treat various diseases. However, the effect of TIL on pancreatic cancer (PC) and its underlying mechanisms ... aims to reveal the anti-PC effect of TIL and clarify its mechanism. The inhibitory effects of TIL on PC growth were studied both in vitro ... and molecular simulation analysis were combined to identify TIL molecular targets. The clinicopathological significance of Calpain-2 ( ... a PC tissue microarray. Herein, we showed that TIL was an effective anti-PC drug. CAPN2 was ...
Tópico(s): Cancer-related molecular mechanisms research
2024 - Elsevier BV | Phytomedicine
Includes index. Book.
0000 - Gale Group | The Making of Modern World
Roberto A. Leon‐Ferre, Sarah Flora Jonas, Roberto Salgado, Sherene Loi, Vincent de Jong, Jodi M. Carter, Torsten O. Nielsen, Samuel Leung, Nazia Riaz, Stephen Chia, Gérôme Jules-Clément, Giuseppe Curigliano, Carmen Criscitiello, Vincent Cockenpot, Matteo Lambertini, Vera J. Suman, Barbro Linderholm, John W.M. Martens, Carolien H. M. van Deurzen, Anne Timmermans, Tatsunori Shimoi, Shu Yazaki, Masayuki Yoshida, Sung‐Bae Kim, Hee Jin Lee, Maria Vittoria Dieci, Guillaume Bataillon, Anne Vincent‐Salomon, Fabrice André, Marleen Kok, Sabine C. Linn, Matthew P. Goetz, Stefan Michiels,
Importance The association of tumor-infiltrating lymphocyte (TIL) abundance in breast cancer tissue with cancer recurrence and death in patients with early-stage triple-negative breast cancer (TNBC) who are not ... is unclear. Objective To study the association of TIL abundance in breast cancer tissue with survival among ... radiotherapy but no adjuvant or neoadjuvant chemotherapy. Exposure TIL abundance in breast tissue from resected primary tumors. ... 71]; 55% had stage I TNBC). The median TIL level was 15% (IQR, 5%-40%). Four-hundred ...
Tópico(s): Cancer Cells and Metastasis
2024 - American Medical Association | JAMA
Book.
0000 - Gale Group | The Making of Modern World
Minna Jääskeläinen, Satu Tiainen, Hanna Siiskonen, Maarit Ahtiainen, Teijo Kuopio, Aino Rönkä, Tiia Kettunen, Kirsi Hämäläinen, Kirsi Rilla, Ilkka T. Harvima, Arto Mannermaa, Päivi Auvinen,
... HER2-positive (HER2 +) breast cancer, tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs) may influence the ... was to study the numbers of FoxP3 + regulatory TILs and CD8 + cytotoxic TILs, their correlations with CD68 + and CD163 + TAMs, and ... patients operated between 2001 and 2008. The FoxP3+TIL count (FoxP3+TILs) was assessed using the hotspot method, and the CD8 + TIL count (CD8+mTILs) utilizing a digital image analysis ... areas. The ratios between CD8+mTILs and FoxP3+TILs as well as CD8+mTILs and TAMs were ...
Tópico(s): Cancer Cells and Metastasis
2023 - Springer Science+Business Media | Breast Cancer Research and Treatment
Project Gutenberg
Signed: Gust. Boneauschiöld. "Til Trollhette slusswärks enterprenade hafwa sig anteknat", p. [6]-[8]. Book.
0000 - Gale Group | The Making of Modern World
Siqi Ren, Tianjun Lan, Fan Wu, Suling Chen, Xue Jiang, Chuying Huo, Zitian Li, Shule Xie, Donghui Wu, Ruixin Wang, Yanyan Li, Lin Qiu, Guoxin Huang, Shurui Li, Xiaojuan Wang, Meifeng Cen, Tingting Cai, Zhaoyu Lin, Jinsong Li, Bowen Li,
... patients to identify a new tumor-infiltrating cell (TIL) subtype, CD103+ CD8+ TILs, associated with clinical response, while both in vitro ... efficiency. The regulatory mechanism of the CD103+ CD8+ TILs population was examined by performing cell-cell interaction ... the mIHC images.We established intratumoral CD103+ CD8+ TILs density as a determinant of NACI efficacy in ... results indicated that the population of CD103+ CD8+ TILs was dramatically increased in the responders of NACI- ... analysis confirmed the correlation between intratumoral CD103+ CD8+ TILs density and NACI efficacy in HNSCC patients. Further ...
Tópico(s): Immune Cell Function and Interaction
2023 - Wiley | Cancer Communications
Mogensen, Carl, Muhle, Carl Adolf,
"Efter et noget gammelt manuscript befordret til trykken ved Carl Adolph Muhle." Errata at end of text. Book.
0000 - Gale Group | The Making of Modern World
Robert K. Hills, Rosie Bradley, Jeremy Braybrooke, Richard Gray, Hannah Taylor, Carsten Denkert, Sunil Badve, Rim S. Kim, Magali Lacroix‐Triki, Meredith M. Regan, Daniel F. Hayes, Mitch Dowsett, Andrew Tutt, Richard D. Gelber, David Cameron, Jonas Bergh, Sandra M. Swain, Stefan Michiels, Sherene Loi, Roberto Salgado,
508 Background: High TIL counts are associated with a lower risk of breast cancer recurrence, especially in women with ER negative, HER2 negative ... reported a differential effect of trastuzumab based upon TIL status. We performed a meta-analysis of randomized ... cancer to attempt to validate this finding. Methods: TILs were quantified in 4097 women in 5 randomized ... which found a significant benefit for trastuzumab therapy. TILs were assessed using established International Guidelines, with HERA using digital TIL-scores. The primary outcome was time to first ...
Tópico(s): Advanced Breast Cancer Therapies
2023 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Attributed to Carl Dubb according to Kress Library. No. 4 in bd. 3 of Stridskrifter om lagar. Book.
0000 - Gale Group | The Making of Modern World
Federica Miglietta, Moira Ragazzi, Bethania Fernandes, Gaia Griguolo, Davide Massa, Fabio Girardi, Michele Bottosso, Alessandra Bisagni, Giovanni Zarrilli, Francesca Porra, Daniela Iannaccone, Leocadia Dore, Mariangela Gaudio, Giacomo Santandrea, Matteo Fassan, Marcello Lo Mele, Rita De Sanctis, Alberto Zambelli, Giancarlo Bisagni, Valentina Guarneri, Maria Vittoria Dieci,
... of tumor-infiltrating lymphocyte on residual disease (RD-TIL) in HER2+ patients with breast cancer who failed ... provided by residual cancer burden (RCB) and RD-TILs into a composite score (RCB+TIL). Experimental Design: HER2+ patients with breast cancer treated ... at three institutions were retrospectively included. RCB and TIL levels were evaluated on hematoxylin and eosin–stained ... RCB was significantly associated with OS. Higher RD-TILs were significantly associated with poorer OS as compared with lower RD-TILs (15% cutoff). In multivariate analysis, both RCB and ...
Tópico(s): HER2/EGFR in Cancer Research
2023 - American Association for Cancer Research | Clinical Cancer Research
"Imprimatur And. Wilde. Loc. Cens. Reg."--T.p verso. Attributed to Anders Wilde by Kress Library. Book.
0000 - Gale Group | The Making of Modern World
Zijun Y. Xu‐Monette, Yong Li, Thomas M. Snyder, Tiantian Yu, Tingxun Lu, Alexandar Tzankov, Carlo Visco, Govind Bhagat, Wenbin Qian, Karen Dybkær, April Chiu, Wayne Tam, Youli Zu, Eric D. Hsi, Fredrick B. Hagemeister, Yingjun Wang, Heounjeong Go, Maurilio Ponzoni, Andrés J.M. Ferreri, Michael Møller, Benjamin M. Parsons, Xiangshan Fan, J. Han van Krieken, Miguel Á. Piris, Jane N. Winter, Qingyan Au, Ilan R. Kirsch, Mingzhi Zhang, John D. Shaughnessy, Bing Xu, Ken H. Young,
Abstract Purpose: Tumor-infiltrating B lymphocytes (TIL-B) have demonstrated prognostic and predictive significance in solid cancers. In this study, we aimed to distinguish TIL-Bs from malignant B-cells in diffuse large ... B-cell clonotypes. The frequencies and numbers of TIL-B clonotypes in individual repertoires were correlated with ... fluorescent multiplex IHC at single-cell resolution. Results: TIL-B abundance, evaluated by frequencies of normal B- ... our sequenced cohorts. DLBCLs with high versus low TIL-B abundance displayed distinct GEP signatures, increased pre- ...
Tópico(s): CAR-T cell therapy research
2023 - American Association for Cancer Research | Clinical Cancer Research
Risell, Jöns, Lewenhaupt, Charles Emil, greve, Chydenius, Anders,
At head of title: Imprimatur. N. v. Oelreich. Caption title. Signed: Jöns Risell, advocat fiscal wid Kongl. Bergs-collegium. A pamphlet of this title ...
0000 - Gale Group | The Making of Modern World
Yu-Jing Liang, Qiuyan Chen, Jing-xiao Xu, Xiufeng Liu, Jian‐Chuan Xia, Li‐Ting Liu, Shanshan Guo, Bin Song, Pan Wang, Jibin Li, Qing Liu, Hao‐Yuan Mo, Ling Guo, Rui Sun, Dong–Hua Luo, Jia He, Yina Liu, Cai-Ping Nie, Lin‐Quan Tang, Jiang Li, Hai‐Qiang Mai,
... I study using adjuvant autologous tumour-infiltrating lymphocytes (TILs) following concurrent chemoradiotherapy (CCRT) in nasopharyngeal carcinoma (NPC) ... were randomly assigned to receive CCRT combined with TIL infusion (n = 78) or CCRT alone (n = 78). ... patients received CCRT and patients assigned to the TIL group received TIL infusion within 1 week after CCRT. The primary ... 3-year PFS rate between the CCRT plus TIL infusion group and CCRT alone group (75.6% ... 08; 95% confidence intervals, 0.62–1.89). TIL infusion was safe without grade 3 or 4 ...
Tópico(s): Cancer Immunotherapy and Biomarkers
2023 - Elsevier BV | European Journal of Cancer
OAPEN Free
Attributed to Carl Christian Pflueg by Kress Library. Signed: X. Kress Library identifies Z as Friedrich Buchwald. Book.
0000 - Gale Group | The Making of Modern World
MacLean Hall, Jamie K. Teer, Xiaoqing Yu, Holly Branthoover, Sebastian Snedal, Madeline Rodríguez-Valentín, Luz Nagle, Ellen Scott, Benjamin Schachner, Patrick Innamarato, Amy M Hall, Jamie Blauvelt, Carolyn J. Rich, Allison Richards, Jake Ceccarelli, TJ Langer, Sean Yoder, Matthew Beatty, Cheryl A. Cox, Jane L. Messina, Daniel Abate‐Daga, James J. Mulé, John E. Mullinax, Amod A. Sarnaik, Shari Pilon‐Thomas,
... Adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TILs) is a promising immunotherapeutic approach for patients with ... contribution of neoantigen-specific CD4 + T cells within TIL infusion products remains underexplored and therefore offers a significant opportunity for progress. Methods We analyzed infused TIL products from metastatic melanoma patients previously treated with ... for the presence of neoantigen-specific T cells. TILs were enriched on reactivity to neoantigen peptides derived ...
Tópico(s): Immune Cell Function and Interaction
2023 - BMJ | Journal for ImmunoTherapy of Cancer