Iina Aaltonen, Timo Salmi, Ilari Marstio,
The manufacturing industry has high expectations for the benefits of collaborative robots. The term collaborative robots, however, encompasses multiple levels of collaboration ranging from coexistence to joint object manipulation. We attempt to refine the levels of collaboration between human workers and collaborative robots by reviewing literature and using case study examples. Distinguishing between the different levels is important because of the requisite safety issues and for the purpose of ...
Tópico(s): Digital Transformation in Industry
2018 - Elsevier BV | Procedia CIRP
Jani Paulin, Jouni Kurola, Sanna Salanterä, Hans Moen, Nischal Guragain, Mari Koivisto, Niina Käyhkö, Venla Aaltonen, Timo Iirola,
Abstract Background Emergency Medical Services (EMS) and Emergency Departments (ED) have seen increasing attendance rates in the last decades. Currently, EMS are increasingly assessing and treating patients without the need to convey patients to health care facility. The aim of this study was to describe and compare the patient case-mix between conveyed and non-conveyed patients and to analyze factors related to non-conveyance decision making. Methods This was a prospective study design of EMS patients ...
Tópico(s): Healthcare Policy and Management
2020 - BioMed Central | Scandinavian Journal of Trauma Resuscitation and Emergency Medicine
Cobots have been expected to provide the missing link towards flexible production by simple programming and the cobots' ability to work next to human workers without the need to install cumbersome and space-intensive fences. Before these expectations can be met, however, we need to identify what the current barriers and development needs for cobots are from the point of view of both industry and academia. An online questionnaire considering the deployment of collaborative robots was answered by ...
Tópico(s): Occupational Health and Safety Research
2019 - Elsevier BV | Procedia Manufacturing
Kirsi Ollonqvist, Hanna Palkeinen, T Aaltonen, Timo Pohjolainen, Pauli Puukka, Katariina Hinkka, Seppo Pöntinen,
Loneliness among frail older people predicts increased use of health services, early institutionalisation and increased mortality. The objective of this study was to determine the effects of a new rehabilitation model on loneliness among frail older people. This randomized controlled multi-centre trial with a 12-month follow-up was implemented in Finland. A total of 708 community-dwelling people aged 65+ years with progressively decreasing functional capacity participated. Participants were randomly ...
Tópico(s): Health, psychology, and well-being
2008 - Tech Science Press | International Journal of Mental Health Promotion
Katri Turunen, Laura Aaltonen-Määttä, Timo Törmäkangas, Timo Rantalainen, Erja Portegijs, Sirkka Keikkala, Marja-Liisa Kinnunen, Taija Finni, Sarianna Sipilä, Riku Nikander,
The aim of this study is to evaluate the effects of multicomponent rehabilitation on physical activity, sedentary behavior, and mobility in older people recently discharged from hospital.Randomized controlled trial.Home and community.Community-dwelling people aged ⩾60 years recovering from a lower limb or back musculoskeletal injury, surgery, or disorder were recruited from local health center hospitals and randomly assigned into an intervention (n = 59) or a control (standard care, n = 58) group.The six- ...
Tópico(s): Balance, Gait, and Falls Prevention
2020 - SAGE Publishing | Clinical Rehabilitation
Jarkko Ihanus, Timo S. Hänninen, Timo Hatanpää, Titta Aaltonen, I. Mutikainen, Timo Sajavaara, J. Keinonen, Mikko Ritala, Markku Leskelä,
SrS and BaS thin films were grown on glass substrates using an atomic layer deposition (ALD) technique and (C5iPr3H2)2Sr(THF) (1), (C5Me5)2Sr(THF)x (2), (C5Me5)2Ba(THF)x (3), and H2S as precursors. Deposition temperatures were 120−460, 155−400, and 180−400 °C with 1, 2, and 3, respectively. Growth rate of the films varied between 0.6 and 3.0 Å/cycle and all the films were polycrystalline as deposited. The amount of C, H, and O residues was found to be 0.1−0.6 at. % in the films grown at 300 °C as determined ...
Tópico(s): Catalytic Processes in Materials Science
2002 - American Chemical Society | Chemistry of Materials
Pertti Aaltonen, Timo Saario, Päivi Karjalainen‐Roikonen, Juha Piippo, S. Tähtinen, M. Itäaho, H. Hänninen,
A new mechanistic model for environmentally assisted cracking (EAC) of metallic materials is presented. In this model the mechanism of cracking involves selective dissolution or oxidation of metallic cations in the oxide film and transport of the generated vacancies to the base metal ahead of the crack tip. The mechanism of cracking is based on interactions of vacancies with dislocations enhancing concentration of slip to the highly stressed region ahead of the crack tip. The validity of the model ...
Tópico(s): Microstructure and Mechanical Properties of Steels
1996 - | CORROSION
Tero Ylisaukko‐oja, Jaakko Aaltonen, Heikki Nuutinen, Timo Blomster, Airi Jussila, Markku Pajala, Kimmo Salminen, Veikko Moilanen, Kalle Hakala, Mikko Kellokumpu, Kari Toljamo, Henna Rautiainen, Juha Kuisma, Markku Peräaho, Pauliina Molander, Jouni Silvennoinen, Ville Liukkonen, Hans Henricson, Jyrki Tillonen, Mirva Esterinen, Christian Nielsen, Eija Hirsi, Margus Lääne, Ulla-Maija Suhonen, Ilkka Vihriälä, Petri Mäkelä, Mika Puhto, Jari Punkkinen, Hannu Sulonen, Sauli Herrala, Jari Jokelainen, Klaus Tamminen, Taina Sipponen,
The efficacy and tolerability of vedolizumab in the treatment of inflammatory bowel diseases (IBD) has been demonstrated in an extensive GEMINI clinical trial programme. Clinical trials represent highly selected patient populations and, therefore, it is important to demonstrate effectiveness in real-life clinical practice. We set out to assess real-world treatment outcomes of vedolizumab in a nationwide cohort of treatment refractory Finnish Crohn's disease (CD) and ulcerative colitis (UC) patients. ...
Tópico(s): Helicobacter pylori-related gastroenterology studies
2017 - Taylor & Francis | Scandinavian Journal of Gastroenterology
Titta Aaltonen, Mikko Ritala, Timo Sajavaara, J. Keinonen, Markku Leskelä,
Platinum thin films were grown at 300 °C by atomic layer deposition (ALD) using (methylcyclopentadienyl)trimethylplatinum (MeCpPtMe3) and oxygen as precursors. The films had excellent uniformity, low resistivity, and low-impurity contents. Structural studies by X-ray diffraction showed that the films were strongly (111) oriented. Growth rates of 0.45 Å cycle-1 were obtained with 4 s total cycle times. The film thickness was found to linearly depend on the number of the reaction cycles. Also, the possible ...
Tópico(s): Catalytic Processes in Materials Science
2003 - American Chemical Society | Chemistry of Materials
K. Antonius, Marja Aaltonen, Marjatta Uosukainen, Timo Hurme,
Tópico(s): Forest Insect Ecology and Management
2011 - Springer Science+Business Media | Genetic Resources and Crop Evolution
Jonathan Williams, John N. Crowley, Hubertus Fischer, Hartwig Harder, Mònica Martínez, Tuukka Petäjä, Janne Rinne, Jaana Bäck, Michael Boy, Miikka Dal Maso, J. Hakala, M. K. Kajos, P. Keronen, Pekka Rantala, Juho Aalto, Hermanni Aaltonen, Jussi Paatero, Timo Vesala, Hannele Hakola, Janne Levula, Toivo Pohja, Frank Herrmann, J. Auld, E. Mesarchaki, Weihua Song, Noureddine Yassaa, A. C. Nölscher, Anita Johnson, Thomas Custer, Vinayak Sinha, J. Thieser, N. Pouvesle, Domenico Taraborrelli, Mingjin Tang, Heiko Bozem, Z. Hosaynali-Beygi, R. Axinte, R. Oswald, Anna Novelli, Dagmar Kubistin, Korbinian Hens, U. Javed, K. Trawny, C. Breitenberger, Pablo J. Hidalgo, C. J. Ebben, Franz M. Geiger, A. L. Corrigan, Lynn M. Russell, H. G. Ouwersloot, Jordi Vilà-Guerau De Arellano, L. Ganzeveld, Alexander L. Vogel, M. H. Beck, A. Bayerle, Christopher J. Kampf, M. Bertelmann, Franziska Köllner, Thorsten Hoffmann, J. Valverde, Díaz González, Marja‐Liisa Riekkola, Markku Kulmala, Jos Lelieveld,
Abstract. This paper describes the background, instrumentation, goals, and the regional influences on the HUMPPA-COPEC intensive field measurement campaign, conducted at the Boreal forest research station SMEAR II (Station for Measuring Ecosystem-Atmosphere Relation) in Hyytiälä, Finland from 12 July–12 August 2010. The prevailing meteorological conditions during the campaign are examined and contrasted with those of the past six years. Back trajectory analyses show that meteorological conditions ...
Tópico(s): Plant responses to elevated CO2
2011 - Copernicus Publications | Atmospheric chemistry and physics
Matti Putkonen, Titta Aaltonen, Mari Alnes, Timo Sajavaara, Ola Nilsen, Helmer Fjellvåg,
Five different lithium containing compounds, all representing different chemical systems, were studied in order to deposit lithium containing films by atomic layer deposition ALD. The studied compounds were a lithium β-diketonate Li(thd) (thd = 2,2,6,6-tetramethyl-3,5-heptanedionate), a lithium alkoxide LiOtBu (OtBu = tert-butoxide), a lithium cyclopentadienyl LiCp (Cp = cyclopentadienyl), a lithium alkyl n-butyllithium, and a lithium amide lithium dicyclohexylamide. Films containing lithium carbonate (Li2CO3) ...
Tópico(s): Ferroelectric and Piezoelectric Materials
2009 - Royal Society of Chemistry | Journal of Materials Chemistry
Olli Aaltonen, Pekka Niemi, Timo Nyrke, Marja Tuhkanen,
Competing predictions concerning phoneme discrimination were tested by means of event-related potentials. In research on speech perception, one tradition stems from the physiology of the auditory system whereas another emphasizes categorical perception which involves a marked psychological component. The stimuli were the end points of the Finnish (i)-(y) continuum together with the intermediate boundary sound. Two of these stimuli were presented in each block of trials. One (the 'standard') had a high ...
Tópico(s): Multisensory perception and integration
1987 - Elsevier BV | Biological Psychology
Pihla Pakkanen, Leena‐Maija Aaltonen, Timo Sorsa, Taina Tervahartiala, Jaana Hagström, Taru Ilmarinen,
Abstract Background Biomarkers that could predict malignant transformation of recurrent respiratory papillomatosis (RRP) would be useful in patient follow‐up. We investigated whether serum matrix metalloproteinase 8 (MMP‐8) and tissue inhibitor of metalloproteinase 1 (TIMP‐1) could predict malignant transformation of RRP and whether they associate with survival in laryngeal squamous cell carcinoma (LSCC) without preexisting RRP. Methods We analyzed serum MMP‐8 (S‐MMP‐8) and serum TIMP‐1 (s‐TIMP‐1) in ...
Tópico(s): Blood Coagulation and Thrombosis Mechanisms
2018 - Wiley | Head & Neck
Eija Kaasinen, Matti Aaltonen, Juha Kolari, Suvi Melakoski, Timo Laakko,
The next big challenge of the Internet is mobile access. More and more information is available on the Internet and intranets and mobile users will also need access to it. Wireless Application Protocol (WAP) based devices make it possible to access Wireless Markup Language (WML) based services with mobile browsers. The first WAP compliant devices have already been released on the market and more are to come. In the future there will be a need for Web services that are specially targeted for mobile ...
Tópico(s): Mobile and Web Applications
2000 - Elsevier BV | Computer Networks
Hermanni Aaltonen, Jukka Pumpanen, Hannele Hakola, Timo Vesala, Sirpa Rasmus, Jaana Bäck,
Abstract. Soil provides an important source of volatile organic compounds (VOCs) to atmosphere, but in boreal forests these fluxes and their seasonal variations have not been characterized in detail. Especially wintertime fluxes are almost completely unstudied. In this study, we measured the VOC concentrations inside the snowpack in a boreal Scots pine (Pinus sylvestris L.) forest in southern Finland, using adsorbent tubes and air samplers installed permanently in the snow profile. Based on the VOC ...
Tópico(s): Soil Carbon and Nitrogen Dynamics
2012 - Copernicus Publications | Biogeosciences
Timo Kuuluvainen, Inari Ylläsjärvi,
Abstract This paper reviews the doctoral thesis of Viktor Toivo Aaltonen, published in 1919. The study was the first, and to this date the only detailed ecological description of the structure and regeneration of natural Pinus sylvestris-dominated dry heath forests in northern Finland. The average density of Pinus seedlings was 8766 ha–1. In general, Calluna sites had the most seedlings, followed by Cladina sites, postfire areas and Empetrum sites. Seedling abundance and quality declined with decreasing ...
Tópico(s): Forest ecology and management
2010 - Taylor & Francis | Scandinavian Journal of Forest Research
Pekka Leinonen, Vesa Aaltonen, Sanna Koskela, Petri Lehenkari, Timo Korkiamäki, Juha Peltonen,
Purpose: Calcium wave propagation and connexin 26, 32 and 43 expression were studied in normal and malignant urothelial cells.Materials and Methods: Human urothelial cell cultures were established from tissue biopsies obtained from three healthy control persons and compared to human transitional cell carcinoma (TCC) cell line 5637. Fluo-3 was used to study intercellular calcium signaling in urothelial cells. The cells were stimulated mechanically in the presence of inhibitors of gap-junctional or ...
Tópico(s): Heat shock proteins research
2007 - Taylor & Francis | Cell Communication & Adhesion
Inger Carlsson, Mika Laitinen, Jennifer E. Scott, Henna Louhio, Louiza S. Velentzis, Timo Tuuri, Johanna Aaltonen, Olli Ritvos, Robert Winston, Outi Hovatta,
The receptor tyrosine c-Kit and its cognate ligand, c-Kit ligand (KL, stem cell factor, SCF), are involved in ovarian follicular development in several animal species. We studied the expression of KL and c-Kit using in situ hybridization and immunohistochemistry in donated human ovarian cortical tissue. The KL transcripts were expressed in granulosa cells of primary follicles, whereas the expression of c-Kit was confined to the oocyte and granulosa cells in primary and secondary follicles. We employed ...
Tópico(s): Pluripotent Stem Cells Research
2006 - Bioscientifica | Reproduction
L. Aaltonen, Erkka Syvälahti, E Iisalo, Timo Peltomäki,
The anticholinergic activity in serum of depressive patients receiving amitriptyline (50-300 mg/day) or doxepin (50-225 mg/day) was measured using a radioreceptor assay. In this method the membrane suspension prepared from rat brain was able to bind the potent muscarinic antagonist, quinuclidinyl benzilate. Using atropine as a standard, the antimuscarinic activity of several compounds can be measured in the serum of patients receiving drugs with anticholinergic effects or side-effects. The steady ...
Tópico(s): Ion channel regulation and function
1985 - Wiley | Acta Pharmacologica et Toxicologica
Petra Alén, Titta Aaltonen, Mikko Ritala, Markku Leskelä, Timo Sajavaara, J. Keinonen, Jacob C. Hooker, Jan Willem Maes,
Ta(Si)N thin films were deposited by atomic layer deposition (ALD) from tantalum chloride, ammonia, and tris(dimethylamino)silane (TDMAS). TDMAS was used as a reducing agent and as a silicon precursor. The pulsing order and the length of the TDMAS pulse were optimized. The deposition temperature was varied between 300 and 500°C. The film properties were analyzed by time-of-flight elastic recoil detection analysis, energy dispersive X-ray spectroscopy, X-ray diffraction, and the standard four-point ...
Tópico(s): Metal and Thin Film Mechanics
2004 - Institute of Physics | Journal of The Electrochemical Society
Caj Södergård, Matti Aaltonen, Sari Hagman, Mikko Hiirsalmi, Timo Järvinen, Eija Kaasinen, Timo Kinnunen, Juha Kolari, Jouko Kunnas, Antti Tammela,
Fast networks enable the delivery of TV and newspaper content over an Internet connection. This enables new types of integrated publications that include features from both media. The IMU system, described in this paper, automatically integrates newspaper and TV content into a continuously updated World Wide Web-multimedia publication. An active proxy server pursues the integration and delivers the publication through an ATM fibre link to fast networks, such as the bi-directional cable TV network ...
Tópico(s): ICT Impact and Policies
1999 - Elsevier BV | Computer Networks
Timo Kiljunen, Aki Kangasmäki, Aili Aaltonen, Kalevi Kairemo, Kaarina Partanen, Greetta Joensuu, Tuomo Alanko, Leila Vaalavirta, Timo Joensuu,
Background. Prostate cancer (PCa) patients with metastatic disease often suffer from skeletal pain and urinary retention impairing their quality of life. Prophylactic radiotherapy to bone metastases planned concomitantly with primary PCa radiotherapy could enable more precise control of combined dose in healthy tissues when compared to sequential palliative treatment.Materials and methods. Volumetric modulated arc therapy (VMAT) was planned for 14 PCa patients with primary bone metastases. The bone ...
Tópico(s): Management of metastatic bone disease
2014 - Taylor & Francis | Acta Oncologica
Jonas Bondestam, M.-A. Huotari, Anita Morén, Jarkko Ustinov, Noora Kaivo-Oja, Johanna Kallio, Nina Horelli‐Kuitunen, Jaakko Aaltonen, Mie Fujii, Aristidis Moustakas, Peter ten Dijke, Timo Otonkoski, Olli Ritvos,
Transforming growth factor-β (TGF-β) superfamily related growth factors signal by binding to transmembrane type I and type II receptor serine/threonine kinases (RSTK), which phosphorylate intracellular Smad transcription factors in response to ligand binding. Here we describe the cloning of the human type I RSTK activin receptor-like kinase 7 (ALK7), an orthologue of the previously identified rat ALK7. Nodal, a TGF-β member expressed during embryonic development and implicated in developmental events ...
Tópico(s): Genetic Syndromes and Imprinting
2001 - Karger Publishers | Cytogenetic and Genome Research
Tuula Palmén, Heikki Ahola, Jaan Palgi, Petri Aaltonen, Pauliina Luimula, Shixuan Wang, Ilkka Jaakkola, Mikael Knip, Timo Otonkoski, Harry Holthöfer,
The NPHS1 gene product, nephrin, is a crucial component of the glomerular filtration barrier preventing proteinuria and previously assumed to be kidney-specific. The aim of this study was to describe the expression of nephrin mRNA and protein in human pancreas as well as identify the nephrin-expressing cell types. RNA dot blot, reverse transcriptase-polymerase chain reaction, sequencing, immunoblotting and dual immunofluorescence were used for the characterisation of nephrin in the pancreas. Except ...
Tópico(s): Renal Diseases and Glomerulopathies
2001 - Springer Science+Business Media | Diabetologia
Aaro Haapaniemi, Petri Koivunen, Kauko Saarilahti, Ilpo Kinnunen, Jussi Laranne, Leena‐Maija Aaltonen, Mervi Närkiö, Paula Lindholm, Reidar Grénman, Antti Mäkitie, Timo Atula,
The purpose of this study was to acquire nationwide data on the management and outcome of laryngeal squamous cell carcinoma (SCC) in Finnish university hospitals over a 5-year posttreatment follow-up.All records of patients diagnosed and treated for primary laryngeal SCC during 2001 to 2005 were reviewed.Three hundred sixty-six patients with laryngeal cancer were identified, 360 of whom had laryngeal SCC. Three hundred forty-two patients with laryngeal SCC (95%) were treated with curative intent. ...
Tópico(s): Esophageal Cancer Research and Treatment
2014 - Wiley | Head & Neck
KJ Aaltonen, Tuulikki Sokka, Timo Möttönen, Markku Korpela, Riitta Komulainen, Tea Uusitalo, S Salomaa, Toini Uutela, Heikki Valleala, for the RAMI study group,
We aimed to conduct a cross-sectional overview of patients with rheumatoid arthritis (RA) in outpatient specialized clinics in Finland.Consecutive patients were enrolled in the study. The data collected comprised demographic, disease- and treatment-related variables.Between November 2011 and May 2012, 890 patients with RA (77% female) were enrolled from 14 sites. The median age was 59.8 years and the time from diagnosis 7.2 years. Values for the Disease Activity Score using 28 joint counts (DAS28) ...
Tópico(s): Chronic Lymphocytic Leukemia Research
2014 - Taylor & Francis | Scandinavian Journal of Rheumatology
Aarni Soppi, Pekka Heino, Terhi Kurko, Timo Maljanen, Leena Saastamoinen, Katri Aaltonen,
Tópico(s): Healthcare Policy and Management
2018 - Elsevier BV | Health Policy
Janne F. J. Korhonen, Mari Pihlatie, Jukka Pumpanen, Hermanni Aaltonen, P. Hari, Janne Levula, Antti‐Jussi Kieloaho, Eero Nikinmaa, Timo Vesala, Hannu Ilvesniemi,
Abstract. The productivity of boreal forests is considered to be limited by low nitrogen (N) availability. Increased atmospheric N deposition has altered the functioning and N cycling of these N-sensitive ecosystems by increasing the availability of reactive nitrogen. The most important components of N pools and fluxes were measured in a boreal Scots pine stand in Hyytiälä, Southern Finland. The measurements at the site allowed direct estimations of nutrient pools in the soil and biomass, inputs ...
Tópico(s): Soil Carbon and Nitrogen Dynamics
2013 - Copernicus Publications | Biogeosciences
Pei T. Mah, Timo Laaksonen, Thomas Rades, Jaakko Aaltonen, Leena Peltonen, Clare J. Strachan,
Milling is an attractive method to prepare amorphous formulations as it does not require the use of solvents and is suitable for thermolabile drugs. One of the key critical quality attributes of milled amorphous formulations is their dissolution behavior. However, there are limited studies that have investigated the relationship between degree of disorder induced by milling and dissolution behavior. The main aim of this study was to identify the analytical technique used to characterize degree of ...
Tópico(s): Crystallography and molecular interactions
2013 - American Chemical Society | Molecular Pharmaceutics