Giles Smith, Andrew Robson, Anthony Boullemier, Lucy Alexander, Tony Harwood, Lydia Sparrow, Robert Cole, Andrew Pierce, DJM, Alexandra Frean, Tom Griffiths, Alexandra Blair, Tim Loughton, Alexandra Blair, Education Correspondent, Sheelah Kolhatkar, Simon Cambers, Philip Howard, Camilla Cavendish, Jonny Wilkinson, David Chater, Barry Turner, James Bone, Matt Hughes and Gary Jacob, Patrick Kidd, Matthew Hoggard, Cllr Steven Bate, Wendy Ide, Iain Haxton, Geoff Brown, Lucy Bannerman, Joe Joseph, Andrew Norfolk, Pat Gibson, Tim Cartwright, Lewis Smith Science Reporter, Donald Hutera, Sue Rabbitt Roff, Feargus O'sullivan, Tom Bawden, Dominic Walsh, Joanna Weinberg, Debra Craine, Gary Rotolo, Jim Coleman, Dean Godson, Angela Jameson Industrial Correspondent, Dalya Alberge Arts Correspondent, Richard Ford Home Correspondent, Alan Hamilton, Stephen Farrell, Ben Webster and Richard Ford, Richard Lloyd Parry, Ian MacKinnon, Adam Sherwin Media Correspondent, Matt Dickinson Chief Football Correspondent, Sholto Byrnes, John Carr and Steve Bird, Hugo Rifkind, Angela Jameson, Bob Woolmer, Gary Duncan Economics Editor, Oliver Kay, Joe Versus, Elizabeth Judge, Caroline Merrell and Liz Chong, Scott Liddle, Alexandra Frean, Alexandra Blair and Tony Halpin, John Westerby, Patrick Hosking Investment Editor, David Miller, Rob Wright, Martin Lewis, David Powell Athletics Correspondent, Raymond Keene, Sean MacAulay, Richard Ford and Sean O'Neill, Matt Hughes, Rebecca O'Connor, Gary Duncan, Economics Editor, Richard Ford and James Bone, Rosemary Bennett Deputy Political Editor, Bronwen Maddox, Patrick Hosking, Helen Nugent, Christopher Martin-Jenkins Chief Cricket Correspondent, Roger Boyes, Anna Del Conte, Peter Dixon, Gabriel Rozenberg Economics Reporter, Nick Hasell, Sean O'Neill and Roger Boyes, Julian Muscat, Paul Simons, Jack Malvern and Mark Thomlinson, M. Ayrton, Mary Ann Sieghart, James Doran, Jonathan Clayton, Ian Johns, Dominic Maxwell, Matthew Parris, Julia Shipway, George Caulkin, Stephen Hoare, Andrew Ellson, Brenda Despontin, Tony Dawe, Richard Beeston, Peter Jenson, David Sanderson, Jack Malvern Arts Reporter, Catherine Philp, Martin Waller, Chris Ayres, Hajar Javaheri, Carl Mortished International Business Editor, Mark Baldwin, Nigel Hawkes Health Editor, Sarah Butler, Patrick Foster, Benedict Nightingale, Gary Jacob and Oliver Kay, Angus Batey, Dr Thomas Stuttaford, Stephen Dalton, Tim Luckhurst, Richard Morrison, James Christopher, Michael Evans, Fiona Beckett, Alexandra Blair Education Correspondent, Owen Slot, Olav Bjortomt, Clare Gibson, Kara Gammell, Joe Bolger, Damian Barr,
... University Setting up a home on a budget Kara Gammell lists the items that you cannot live ...
2006 - Gale Group | TDA
Mehmet Kara, Tina O’Grady, Emily R. Feldman, April Feswick, Yiping Wang, Erik K. Flemington, Scott A. Tibbetts,
Gammaherpesviruses, including the human pathogens Epstein⁻Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) are oncogenic viruses that establish lifelong infections in hosts and are associated with the development of lymphoproliferative diseases and lymphomas. Recent studies have shown that the majority of the mammalian genome is transcribed and gives rise to numerous long non-coding RNAs (lncRNAs). Likewise, the large double-stranded DNA virus genomes of herpesviruses undergo pervasive ...
Tópico(s): Cytomegalovirus and herpesvirus research
2019 - Multidisciplinary Digital Publishing Institute | Non-Coding RNA
Jonathan Northcroft, Shane Wallin, Gareth Rubin, Hala Jaber, Philip Marsden, Jim Munro Football Editor, Mike Theodoulou, William Kay, John Dugdale, Mike Vandy, Matthew Wall, Barbara Hall, Tony Barrell, Gary Flower, Daniel Barenboim, David Brown, Jon Swain, Jim Munro, J Wilson, Helen Davies, Peter Whittle, Rob Hughes, John Peter, Sally Brock, Colin Brennan, Professor Gideon Garter, Aviram Zino, Amanda Ursell, Robin Eggar, Adam Zamoyski, Andrew Longmore, Andy Thornton, Richael Bridge, Jamie Redknapp, Will Kemp, Walter Zwick, Gareth Walsh, Nicola Thorold Director of Theatre, Bryan Wharton, Frank Whitford, Ivo Tennant, Nicolette Jones, Caroline Brannigan, Kathryn Cooper, Damon Heath, P D, David Smith, Kenneth Wood, David Cracknell Political Editor, Dr. Abdulkarim Khalil, Andrew Sullivan, Martin Brundle, John Bent, Clive Davis, Ben Bryant, Martin James, Simon Wilde, Jonathan Ungoed-Thomas, Gemma Scott-Martin, Tom Walker, Lori Gottlieb, Robert Winnett, Irwin Stelzer, Peter Wilson, Rosie Millard, Coquelle Pot, David Dougill, Emma John, Christopher Hart, Marsha Coupe, Stuart Barnes, Peter Jones, Damon Hill, Rob Maul, Nick Davies, Simon Webbe, Mark Edward, Elizabeth Scott-Baumann, Bob MacDonald, Hugh Canning, Geraldine Hackett Education Correspondent, Victoria Segal, David Cairns, Edward Porter, Peter Conradi, Stewart Lee, Sir John Eliot Gardiner, Michael Portillo, Fergus Garrett, Anthony Peregrine, Patricia Nicol, Sarah Dempster, Adrian Turpin, Katharine Houreld, Dave Pollard, Robin Nayler, Richard Horne, Richard Fletcher, Alan Taylor, Lydia Slater, Jeff Potter, Holly Watt, Pat Malone, Chris Johnston, Antony Jay, Paul Ham, Stuart Wavell, Karen Burke, Raymond Loewy, Paul Donovan, Giles Coran, Turki Al-Faisal Ambassador, Steve Waugh, Chris Woodhead, Steve Boyd, Gareth Crockett, Jasper Gerard, Derek Clements, Paul Driver, John Follain, David Oldham, Ian Hawkey, Dori Schmetterling, Stuart Andrews, Shelley Von Strunckel, David Leppard, Mark Edwards, M Standerlane, Rachel Bridge, Heston Blumenthal, Susan Clark, Tom Howard, Gary Chaplin, Dick Kirby, Sarah Kate Templeton Medical Correspondent, Jeff Tate, Robert Lacey, Mrs V Connelly, James Morris, Alison Elvey de Rios, Raymond Keene, Rod Liddle, Penelope Lively, Cosmo Landesman, Marie Colvin, Rick Bakker, Emma Smith, Dominic O'Connell, Blower Spindle, Peter Koenig, Barry Flatman, Brian Deer, Uzi Mahnaimi, Stephen Bleach, Clifford Coonan, Tina Ogle, Peter Boyle, Caroline Donald, Lois Rogers Social Affairs Editor, Jeremy Lewis, Nick Rennison, C J, Mary Monk, Trevor Lewis, Clarissa Dickson Wright, Bryan Appleyard, Andrew White, Stephen Armstrong, John Elliott, Russell Miller, Stephen Blech, P Seymour, Bethan Cole, Victoria O'brien, Roland White, Shane Watson, Abul Taher, Maurice Chittenden, Richard Brooks Arts Editor, Colin Cohen, Virginia Rounding, Peter Wilby, Richard Rae, Clyde Mafcy, Clive Davies, Sophie Kirkham, Michael Margrett, D J Taylor, Clare Francis, John Harlow, Nicole Cooke, Chris Haslam, Dipesh Gadher, Mark Kleinman, Richard Sanderson, John Waples, Hunter Davies, Caroline, Peter Willson, Jeremy Hart, A A Gill, Kara O'Reilly, Matthew Campbell, John Carey, Sarahy Dempster, Claire Newelt, Mary Braid, Simon Jenkins, Stephen Pettitt, Claudia Croft, B Spencer, Will Iredale, Jessica Bown, Jeremy Langmead, Justin Sparks, Sally Kinnes, Sean O'brien, Tom Pattinson, Liam Clarke, Naomi Caine, Nigel Powell, Camilla Wright, Brian Doogan, John Aizlewood, Minette Marrin, Clifford Bishop, Graham Norwood, Andrew Frankel, Joe Lovejoy, Andrew Male, David Budworth, Julian Dare, William Lewis Business editor, Andrew Davidson, Dan Cairns, David Smith Economics Editor, Colin McDoWell's, Robert Randell, Sarah Baxter, Lee Atkins, Brian Schofield, John Walpes, Matthew Goodman, India Knight, William Gray, Kate Spicer, Joanna Simon, John-Paul, Jason Dawe, Dominic Rushe, Sian Griffiths, Karen Robinson, Mike Jupp, Helen Stewart,
... to the country. How will they cope, asks Tina Ogle SAAB SAAB I really enjoyed a preview ...
2005 - Gale Group | Sunday Times HA GDA
Yuejun Zhen, Jie Qian, Kara Follmann, Tina Hayward, Thomas Nilsson, Michael S. Dahn, Yasmin Hilmi, Alicia G. Hamer, Jonathan P. Hosler, Shelagh Ferguson‐Miller,
Theaa3-type cytochromecoxidase ofRhodobacter sphaeroideshas been overexpressed up to seven fold over that in wild-type strains by engineering a multicopy plasmid with all the required oxidase genes and by establishing optimum growth conditions. The two operons containing the three structural genes and two assembly genes for cytochromecoxidase were ligated into a pUC19 vector and reintroduced into several oxidase-deletedR. sphaeroidesstrains. Under conditions of relatively high pH and maximal aeration, ...
Tópico(s): Photoreceptor and optogenetics research
1998 - Elsevier BV | Protein Expression and Purification
Gary H. Posner, Christian Helvig, Dominic Cuerrier, Drew Collop, Aza Z. Kharebov, Kara Ryder, Tina Epps, Martin Petkovich,
The cytochrome P450 enzyme 24-hydroxylase (CYP24) plays a critical role in regulating levels of vitamin D hormone. Aberrant expression of CYP24 has been implicated in vitamin D insufficiency and resistance to vitamin D therapy. We have demonstrated amplified CYP24 expression in uremic rats, suggesting that CYP24 has an etiological role in vitamin D insufficiency commonly associated with chronic kidney disease (CKD). We have designed two new analogues of 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3), namely ...
Tópico(s): Electrolyte and hormonal disorders
2010 - Elsevier BV | The Journal of Steroid Biochemistry and Molecular Biology
Elizabeth George, Shipra Arya, Kara A. Rothenberg, Tina Hernandez‐Boussard, Vy T. Ho, Jordan R. Stern, Hugh A. Gelabert, Jason T. Lee,
Tópico(s): Central Venous Catheters and Hemodialysis
2021 - Elsevier BV | Annals of Vascular Surgery
Johnson C. Y. Pang, Eric L. S. Chan, Herman M. C. Lau, Kara K. L. Reeves, Tina H. Y. Chung, Heidi W. L. Hui, Alfred H. L. Leung, Allan Chak Lun Fu,
Background The COVID-19 pandemic has greatly affected the level of physical activity (PA). However, little is known about its effect on health outcomes. Methods Articles without language restrictions published from the database inception through March 16, 2022, were retrieved using the CINAHL Complete, Cochrane Library, EMBASE, Medline, PubMed, and PsycINFO databases. High-quality articles assessing the effect of PA on psychological and behavioral problems. Additionally, PA, QoL, and/or sleep problems ...
Tópico(s): Physical Activity and Health
2023 - Frontiers Media | Frontiers in Pediatrics
Kara Pryke, Jinu Abraham, Tina M. Sali, Bryan Gall, Iris Archer, Andrew Liu, Shelly Bambina, Jason R. Baird, Michael J. Gough, Marita Chakhtoura, Elias K. Haddad, Ilsa T. Kirby, Aaron Nilsen, Daniel N. Streblow, Alec J. Hirsch, Jessica L. Smith, Victor R. DeFilippis,
The ongoing concurrent outbreaks of Zika, Chikungunya, and dengue viruses in Latin America and the Caribbean highlight the need for development of broad-spectrum antiviral treatments. The type I interferon (IFN) system has evolved in vertebrates to generate tissue responses that actively block replication of multiple known and potentially zoonotic viruses. As such, its control and activation through pharmacological agents may represent a novel therapeutic strategy for simultaneously impairing growth ...
Tópico(s): Viral Infections and Vectors
2017 - American Society for Microbiology | mBio
John G. Hanly, Chris Skedgel, Ingrid Sketris, Charmaine Cooke, TINA LINEHAN, Kara Thompson, Sander Veldhuyzen van Zanten,
To determine the incidence, healthcare utilization, and costs in older adults with gout.A 5-year retrospective case-control study of patients with incident gout and matched controls was performed. Study variables were derived from health administrative data and included patient demographics, International Classification of Diseases diagnostic codes, and healthcare cost information.There were 4,071 cases and 16,281 controls, providing a 5-year incidence of gout of 4.4%. The mean (+/-SD) age (77+/-7.3 ...
Tópico(s): Case Reports on Hematomas
2009 - The Journal of Rheumatology Publishing Company Limited | The Journal of Rheumatology
Herbert Chen, Tracy Wang, Tina Yen, Kara Doffek, Elizabeth A. Krzywda, Sarah Schaefer, Rebecca S. Sippel, Stuart D. Wilson,
To determine whether surgical volume influences the cause of operative failures after parathyroidectomy for hyperparathyroidism.The surgical success rate for hyperparathyroidism from high-volume centers exceeds 95%, but some patients have unsuccessful parathyroidectomies. Although operative failure can be due to hyperfunctioning parathyroid glands in ectopic locations, less experienced surgeons may be more likely to miss an abnormal parathyroid in normal anatomic locations, which we describe as " ...
Tópico(s): Pancreatic and Hepatic Oncology Research
2010 - Lippincott Williams & Wilkins | Annals of Surgery
Ioanna G. Mazotas, Tina Yen, Kara Doffek, Joseph Shaker, Azadeh A. Carr, Douglas B. Evans, Tracy Wang,
Persistent/recurrent hyperparathyroidism occurs in 2%-5% of patients with sporadic primary hyperparathyroidism (PHPT). In this study, the incidence and time to recurrence in patients with single-gland disease (SGD), double adenomas (DAs), or four-gland hyperplasia (FGH) at initial parathyroidectomy were compared.This retrospective review included adult patients with sporadic PHPT who underwent initial parathyroidectomy with intraoperative parathyroid hormone monitoring (IOPTH) from 1/2000 to 12/2016 ...
Tópico(s): Neuroendocrine Tumor Research Advances
2019 - Elsevier BV | Journal of Surgical Research
Peter T. Katzmarzyk, Corby K. Martin, Robert L. Newton, John W. Apolzan, Connie L. Arnold, Terry C. Davis, Kara D. Denstel, Emily F. Mire, Tina K. Thethi, Phillip J. Brantley, William D. Johnson, Vivian Fonseca, Jonathan Gugel, Kathleen Kennedy, Carl J. Lavie, Eboni G. Price‐Haywood, Daniel F. Sarpong, Benjamin Springgate,
Underserved and minority populations suffer from a disproportionately high prevalence of obesity and related comorbidities. Effective obesity treatment programs delivered in primary care that produce significant weight loss are currently lacking. The purpose of this trial is to test the effectiveness of a pragmatic, high intensity lifestyle-based obesity treatment program delivered within primary care among an underserved population. We hypothesize that, relative to patients who receive usual care, ...
Tópico(s): Nutrition and Health in Aging
2018 - Elsevier BV | Contemporary Clinical Trials
Peter T. Katzmarzyk, Corby K. Martin, Robert L. Newton, John W. Apolzan, Connie L. Arnold, Terry C. Davis, Eboni G. Price‐Haywood, Kara D. Denstel, Emily F. Mire, Tina K. Thethi, Phillip J. Brantley, William D. Johnson, Vivian Fonseca, Jonathan Gugel, Kathleen Kennedy, Carl J. Lavie, Daniel F. Sarpong, Benjamin Springgate,
Evidence of the effectiveness of treatment for obesity delivered in primary care settings in underserved populations is lacking.
Tópico(s): Obesity and Health Practices
2020 - Massachusetts Medical Society | New England Journal of Medicine
Kayla L O'Sullivan, Tina Yen, Kara Doffek, Sophie Dream, Ioanna G. Mazotas, Douglas B. Evans, Tracy Wang,
Abstract Background Parathyroidectomy is the only curative treatment for primary hyperparathyroidism (pHPT) and is associated with low morbidity. This study examined the severity of disease and outcomes of parathyroidectomy based on patient age at a high-volume institution. Methods This is a retrospective review of sporadic pHPT patients who underwent initial parathyroidectomy. To study disease severity over time, patients were divided into timeframes: 1999–2007, 2007–2012, and 2013–2018. Elderly was defined ...
Tópico(s): Genetic Syndromes and Imprinting
2021 - Elsevier BV | The American Journal of Surgery
Suphunnika Ibbotson, Tina Dettmer, Sami Kara, Christoph Herrmann,
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2013 - Springer Science+Business Media | The International Journal of Life Cycle Assessment
Tina M. Sali, Kara Pryke, Jinu Abraham, Andrew Liu, Iris Archer, Rebecca M. Broeckel, Julia A. Staverosky, Jessica L. Smith, Ahmed Majeed Al-Shammari, Lisi Amsler, Kayla Sheridan, Aaron Nilsen, Daniel N. Streblow, Victor R. DeFilippis,
Pharmacologic stimulation of innate immune processes represents an attractive strategy to achieve multiple therapeutic outcomes including inhibition of virus replication, boosting antitumor immunity, and enhancing vaccine immunogenicity. In light of this we sought to identify small molecules capable of activating the type I interferon (IFN) response by way of the transcription factor IFN regulatory factor 3 (IRF3). A high throughput in vitro screen yielded 4-(2-chloro-6-fluorobenzyl)-N-(furan-2-ylmethyl)- ...
Tópico(s): Mosquito-borne diseases and control
2015 - Public Library of Science | PLoS Pathogens
Trudy L. Hughes, Tina M. Hahn, Kara K. Reynolds, Donna S. Shewach,
Deoxycytidine kinase is the rate-limiting process in the activation for several clinically important antitumor agents. Previous studies have focused on deoxycytidine (dCyd) and adenosine triphosphate (ATP) as substrates for this enzyme. In view of recent data indicating that uridine triphosphate (UTP) is the physiologic phosphate donor for this enzyme, a study of the kinetic properties of dCyd kinase with dCyd and UTP was undertaken. The results presented here demonstrate that UTP and ATP produce kinetically ...
Tópico(s): Adenosine and Purinergic Signaling
1997 - American Chemical Society | Biochemistry
Tópico(s): Psychotherapy Techniques and Applications
2009 - American Psychological Association | International Journal of Play Therapy
Christian Helvig, Dominic Cuerrier, Christopher M. Hosfield, Breanna Ireland, Aza Z. Kharebov, Jae‐Weon Kim, Navindra J. Ramjit, Kara Ryder, Samir P. Tabash, Andrew M. Herzenberg, Tina Epps, Martin Petkovich,
The progressive decline in kidney function and concomitant loss of renal 1α-hydroxylase (CYP27B1) in chronic kidney disease (CKD) are associated with a gradual loss of circulating 25-hydroxyvitamin D3 (25(OH)D3) and 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3). However, only the decrease in 1α,25(OH)2D3 can be explained by the decline of CYP27B1, suggesting that insufficiency of both metabolites may reflect their accelerated degradation by the key catabolic enzyme 24-hydroxylase (CYP24). To determine whether ...
Tópico(s): Pharmacological Effects and Toxicity Studies
2010 - Elsevier BV | Kidney International
... The consequences of associated thyroid tumorsStuart D.Wilson, Kara M.Doffek, Tracy S.Wang, Elizabeth A.Krzywda, Douglas B.Evans, Tina W.F.Yen2011 | Surgery, Vol. 150, No. 4Is ...
Tópico(s): BRCA gene mutations in cancer
2008 - Radiological Society of North America | Radiology
Bryan Gall, Kara Pryke, Jinu Abraham, Nobuyo Mizuno, Sara Botto, Tina M. Sali, Rebecca M. Broeckel, Nicole N. Haese, Aaron Nilsen, Andrew T. Placzek, Thomas E. Morrison, Mark T. Heise, Daniel N. Streblow, Victor R. DeFilippis,
ABSTRACT The type I interferon (IFN) system represents an essential innate immune response that renders cells resistant to virus growth via the molecular actions of IFN-induced effector proteins. IFN-mediated cellular states inhibit growth of numerous and diverse virus types, including those of known pathogenicity as well as potentially emerging agents. As such, targeted pharmacologic activation of the IFN response may represent a novel therapeutic strategy to prevent infection or spread of clinically ...
Tópico(s): Mosquito-borne diseases and control
2017 - American Society for Microbiology | Journal of Virology
Tina Yen, Tracy Wang, Kara Doffek, Elizabeth A. Krzywda, Stuart D. Wilson,
Background Advances in preoperative imaging and use of intraoperative parathyroid hormone (IOPTH) levels are changing the approach to reoperative parathyroidectomy (ReopPTX). We sought to develop a protocol for imaging and IOPTH monitoring that allows for a focused, successful operative approach. Methods We reviewed our prospective database of consecutive patients with primary hyperparathyroidism who underwent ReopPTX with IOPTH monitoring between December 1999 and June 2007. Results Thirty-nine patients underwent ...
Tópico(s): Medical Imaging and Pathology Studies
2008 - Elsevier BV | Surgery
Andrew J. Leiker, Tina Yen, Dan Eastwood, Kara Doffek, Anikó Szabó, Douglas B. Evans, Tracy Wang,
Minimally invasive parathyroidectomy using intraoperative parathyroid hormone monitoring remains the standard approach to the majority of patients with primary hyperparathyroidism. This study demonstrates that individual patient characteristics do not affect existing criteria for intraoperative parathyroid hormone monitoring.To identify patient characteristics, such as age, sex, race, body mass index (BMI), and renal function, that may affect existing criteria for intraoperative parathyroid hormone ( ...
Tópico(s): Magnesium in Health and Disease
2013 - American Medical Association | JAMA Surgery
Victoria Lai, Tina Yen, Kara Doffek, Azadeh A. Carr, Ty Carroll, Gilbert G. Fareau, Douglas B. Evans, Tracy Wang,
Tópico(s): Vitamin D Research Studies
2016 - Springer Science+Business Media | Annals of Surgical Oncology
Jinu Abraham, Sara Botto, Nobuyo Mizuno, Kara Pryke, Bryan Gall, Dylan T. Boehm, Tina M. Sali, Haihong Jin, Aaron Nilsen, Michael J. Gough, Jason R. Baird, Marita Chakhtoura, Caroline Subra, Lydie Trautmann, Elias K. Haddad, Victor R. DeFilippis,
The innate immune response to cytosolic DNA involves transcriptional activation of type I interferons (IFN-I) and proinflammatory cytokines. This represents the culmination of intracellular signaling pathways that are initiated by pattern recognition receptors that engage DNA and require the adaptor protein Stimulator of Interferon Genes (STING). These responses lead to the generation of cellular and tissue states that impair microbial replication and facilitate the establishment of long-lived, antigen- ...
Tópico(s): Immune Response and Inflammation
2020 - Frontiers Media | Frontiers in Immunology
Stuart D. Wilson, Kara Doffek, Tracy Wang, Elizabeth A. Krzywda, Douglas B. Evans, Tina Yen,
Background Information on thyroid tumors is scant in patients with primary hyperparathyroidism (HPT) and history of head and neck irradiation. The study objective was to investigate thyroid pathology in primary HPT patients with irradiation history presenting for parathyroidectomy. Methods A prospective database of 1,020 parathyroidectomy patients was analyzed. 916 consecutive HPT patients were identified. History of radiation, neck ultrasound results, thyroid operations, and pathology was assessed. ...
Tópico(s): Neuroendocrine Tumor Research Advances
2011 - Elsevier BV | Surgery
Tina B. Lonsdorf, Armita Golkar, Kara M. Lindstöm, Peter Fransson, Martin Schalling, Arne Öhman, Martin Ingvar,
Amygdala reactivity is a heritable trait, potentiated in affective disorders and associated with both the 5-HTTLPR and the COMTval158met polymorphism. Fifty-four healthy volunteers selected a priori based on gender and 5-HTTLPR/rs25531 and COMTval158met genotypes performed a passive viewing task of angry facial expressions using fMRI. Amygdala reactivity and habituation were investigated using the a priori anatomical region of interest (ROI) approach. Furthermore, salivary cortisol and skin conductance ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2011 - Elsevier BV | Biological Psychology
Armita Golkar, Tina B. Lonsdorf, Andreas Olsson, Kara M. Lindström, Jonathan Berrebi, Peter Fransson, Martin Schalling, Martin Ingvar, Arne Öhman,
The lateral prefrontal and orbitofrontal cortices have both been implicated in emotion regulation, but their distinct roles in regulation of negative emotion remain poorly understood. To address this issue we enrolled 58 participants in an fMRI study in which participants were instructed to reappraise both negative and neutral stimuli. This design allowed us to separately study activations reflecting cognitive processes associated with reappraisal in general and activations specifically related ...
Tópico(s): Memory and Neural Mechanisms
2012 - Public Library of Science | PLoS ONE
Tina B. Lonsdorf, Armita Golkar, Kara M. Lindström, Jan Haaker, Arne Öhman, Martin Schalling, Martin Ingvar,
Brain-derived neurotrophic factor (BDNF), the most abundant neutrophin in the mammalian central nervous system, is critically involved in synaptic plasticity. In both rodents and humans, BDNF has been implicated in hippocampus- and amygdala-dependent learning and memory and has more recently been linked to fear extinction processes. Fifty-nine healthy participants, genotyped for the functional BDNFval66met polymorphism, underwent a fear conditioning and 24h-delayed extinction protocol while skin ...
Tópico(s): Neuropeptides and Animal Physiology
2014 - University of Oxford | Social Cognitive and Affective Neuroscience
Patricia Egede, Tina Dettmer, Christoph Herrmann, Sami Kara,
The environmental impacts of electric vehicles (EVs) partially depend on the parameters of their site of operation. Variations of average driving patterns in different geographic locations and the use of heating and cooling due to local climate conditions have an impact on the energy consumption of EVs. In combination with the regional electricity mix these factors influence the environmental impact of EVs. Hence, these influencing factors must be included in an ecological assessment. The Life Cycle ...
Tópico(s): Electric and Hybrid Vehicle Technologies
2015 - Elsevier BV | Procedia CIRP