HENRY NEWBOLT., ROLAND K. WILSON., HENRY HOBHOUSE., MR. LLOYD GEORGE., AUSTIN DOBSON., SIDNEY LOW., DAVID GILL., J. C. RODRIGUES., GONCALVES CRUZ., FOR A. C. KELLY, Assoc.M.INST.C.E., POR W. H. KOEBEL., (POR UM COLLABORADOR., POR LADY SUSAN TOWNLEY.,
... Rios., Insturcção Publica, Litteratura, Bellas Artes, Imprensa. Por Tobias Monteiro., Algumas Outras Cidades Brasileiras. For Tobias Monteiro., Mr. Asquith In East Fife., As Tarifas Da ...
1910 - Gale Group | TDA
Produção Nacional
Revisado por pares
Felipe Monteiro, Tobias Micklitz, Masaki Tezuka, Alexander Altland,
We present a fully analytical description of a many body localization (MBL) transition in a microscopically defined model. Its Hamiltonian is the sum of one- and two-body operators, where both contributions obey a maximum-entropy principle and have no symmetries except hermiticity (not even particle number conservation). These two criteria paraphrase that our system is a variant of the Sachdev-Ye-Kitaev (SYK) model. We will demonstrate how this simple `zero-dimensional' system displays numerous features ...
Tópico(s): Opinion Dynamics and Social Influence
2021 - American Physical Society | Physical Review Research
FRANCIS A. STRINGER., T. A. BRAMSDON, M.P, R11.021., W. C. D. WHETHAM., JOHN C. MEDD., X., RONALD ROSS., BEN TILLETT., E. H. B., J. J., A UNIONIST CANDIDATE. December 27., STEPHEN GWYNN., J. M. F. FULLER., J. DICKERSON DAVIES., W. H. SOUTHON., G. F. FORBES., THORNTON A. WILLIAMS., FREDERICK POLLOCK., THE MAN IN THE STREET., S. HUTCHINSON HARRIS., WM. THOMPSON., B. A. C., L. GARDINER., E. RAY LANKESTER., ADAM SEDGWICK., WILLIAM CARRUTHERS., AUGUST BUSCK., W. AND A. GILBEY., JOHN WRIGHTSON., E. S. ZEBALLOS., BY A. CARNEGIE ROSS, C.B., H.B.M. CONSUL BUENOS AYRES., BY R. A. SANDALL, ACTING BRITISH CONSUL AT THE PORT OF SANTOS., BY A. C. KELLY, ASSOC.M.INST.C.E., BY CAPTAIN G. NUNEZ, OF THE MINISTRY OF MARINE., BY THE HON. JOHN BARRETT, DIRECTOR OF THE INTERNATIONAL BUREAU OF THE AMERICAN REPUBLICS., BY W. H. KOEBEL., BY LIX KLETT, CONSUL-GENERAL OF ARGENTINA IN RIO DE JANEIRO., BY DR. SANTIAGO G. O'FARRELL., BY PROFESSOR AGUSTIN ALVAREZ., BY THE FINANCIAL EDITOR OF THE "BUENOS AYRES STANDARD.", BY LADY SUSAN TOWNLEY., J. C. RODRIGUES., BY DR. ORVILLE A. DERBY, DIRECTOR OF THE BRAZILIAN GEOLOGICAL SURVEY., BY DR. OSWALDO GONCALVES CRUZ., BY SENOR TOBIAS MONTEIRO., BY PROFESSOR ERNESTO NELSON, DIRECTOR OF THE PEDAGOGICAL MUSEUM OF BUENOS AYRES., BY SEÑOR TOBIAS MONTEIRO.,
Births. Marriages. Deaths. Classified Advertising: Household Servants Disengaged., SHIPPING (continued from page 1)., Lectures., Personal.. Law: Judicial ...
1909 - Gale Group | TDA
Frederik Schaltz-Buchholzer, Peter Aaby, Isaquel Silva, Ivan Monteiro, Tobias R. Kollmann, Nelly Amenyogbe, Morten Bjerregaard-Andersen, Christine Stabell Benn,
Abstract Background Maternal priming with the Bacille Calmette-Guérin (BCG) vaccine has been associated with reduced offspring mortality rates. We investigated this association in a cohort of frail neonates. Methods We performed an observational study within a randomized BCG trial conducted at the neonatal intensive care unit (NICU) in Guinea-Bissau from 2015 to 2017. At NICU admission and after informed consent, the maternal scar status was evaluated by visual inspection before neonates were randomized ...
Tópico(s): Child Nutrition and Water Access
2022 - Oxford University Press | The Journal of Infectious Diseases
Randolf Pohl, Aldo Antognini, F. Nez, F. D. Amaro, F. Biraben, J. M. R. Cardoso, D. S. Covita, A. Dax, S. Dhawan, L. M. P. Fernandes, Adolf Giesen, Thomas Graf, T. W. Hänsch, P. Indelicato, L. Julién, Cheng-Yang Kao, Paul Knowles, Éric-Olivier Le Bigot, Yiwei Liu, J. A. M. Lopes, L. Ludhová, C.M.B. Monteiro, F. Mulhauser, Tobias Nebel, Paul Rabinowitz, J.M.F. dos Santos, L. A. Schaller, Karsten Schuhmann, Catherine Schwob, D. Taqqu, J.F.C.A. Veloso, F. Kottmann,
Tópico(s): Scientific Measurement and Uncertainty Evaluation
2010 - Nature Portfolio | Nature
Randolf Pohl, F. D. Amaro, Aldo Antognini, F. Biraben, J. M. R. Cardoso, D. S. Covita, A. Dax, S. Dhawan, L. M. P. Fernandes, Adolf Giesen, Thomas Graf, T. W. Hänsch, P. Indelicato, L. Julién, Cheng-Yang Kao, Paul Knowles, Éric-Olivier Le Bigot, Yiwei Liu, J. A. M. Lopes, L. Ludhová, C.M.B. Monteiro, F. Mulhauser, Tobias Nebel, F. Nez, Paul Rabinowitz, J.M.F. dos Santos, L. A. Schaller, Karsten Schuhmann, Catherine Schwob, D. Taqqu, J.F.C.A. Veloso, F. Kottmann,
We have recently measured the 2S1/2F=1 − 2P3/2F = 2 energy splitting in the muonic hydrogen atom μp to be 49881.88 (76) GHz. Using recent QED calculations of the fine-, hyperfine, QED and finite size contributions we obtain a root-mean-square proton charge radius of rp = 0.84184 (67) fm. This value is ten times more precise, but 5 standard deviations smaller, than the 2006 CODATA value of rp = 0.8768 (69) fm. The source of this discrepancy is unknown. Using the precise measurements of the 1S-2S transition ...
Tópico(s): Scientific Research and Discoveries
2011 - IOP Publishing | Journal of Physics Conference Series
Aldo Antognini, F. Biraben, J. M. R. Cardoso, D. S. Covita, A. Dax, L. M. P. Fernandes, Andrea L. Gouvea, Thomas Graf, T. W. Hänsch, M. Hildebrandt, P. Indelicato, L. Julién, K. Kirch, F. Kottmann, Yiwei Liu, C.M.B. Monteiro, F. Mulhauser, Tobias Nebel, F. Nez, J.M.F. dos Santos, Karsten Schuhmann, D. Taqqu, J.F.C.A. Veloso, Andreas Voß, Randolf Pohl,
We plan to measure several 2S–2P transition frequencies in μ 4 He + and μ 3 He + by means of laser spectroscopy with an accuracy of 50 ppm. This will lead to a determination of the corresponding nuclear rms charge radii with a relative accuracy of 3 × 10 −4 , limited by the uncertainty of the nuclear polarization contribution. First, these measurements will help to solve the proton radius puzzle. Second, these very precise nuclear radii are benchmarks for ab initio few-nucleon theories and potentials. Finally ...
Tópico(s): Advanced Chemical Physics Studies
2011 - NRC Research Press | Canadian Journal of Physics
Aldo Antognini, F. Nez, Karsten Schuhmann, F. D. Amaro, F. Biraben, J. M. R. Cardoso, D. S. Covita, A. Dax, S. Dhawan, Marc Diepold, L. M. P. Fernandes, Adolf Giesen, Andrea L. Gouvea, Thomas Graf, T. W. Hänsch, P. Indelicato, L. Julién, Cheng-Yang Kao, Paul Knowles, F. Kottmann, Éric-Olivier Le Bigot, Yiwei Liu, J. A. M. Lopes, L. Ludhová, C.M.B. Monteiro, F. Mulhauser, Tobias Nebel, Paul Rabinowitz, J.M.F. dos Santos, L. A. Schaller, Catherine Schwob, D. Taqqu, J.F.C.A. Veloso, Jan Vogelsang, Randolf Pohl,
Accurate knowledge of the charge and Zemach radii of the proton is essential, not only for understanding its structure but also as input for tests of bound-state quantum electrodynamics and its predictions for the energy levels of hydrogen. These radii may be extracted from the laser spectroscopy of muonic hydrogen (μp, that is, a proton orbited by a muon). We measured the 2S(1/2)(F=0)-2P(3/2)(F=1) transition frequency in μp to be 54611.16(1.05) gigahertz (numbers in parentheses indicate one standard ...
Tópico(s): Advanced Chemical Physics Studies
2013 - American Association for the Advancement of Science | Science
Randolf Pohl, F. Nez, L. M. P. Fernandes, F. D. Amaro, F. Biraben, J. M. R. Cardoso, D. S. Covita, A. Dax, S. Dhawan, Marc Diepold, Adolf Giesen, Andrea L. Gouvea, Thomas Graf, T. W. Hänsch, P. Indelicato, L. Julién, Paul Knowles, F. Kottmann, Éric-Olivier Le Bigot, Yiwei Liu, J. A. M. Lopes, L. Ludhová, C.M.B. Monteiro, F. Mulhauser, Tobias Nebel, Paul Rabinowitz, J.M.F. dos Santos, L. A. Schaller, Karsten Schuhmann, Catherine Schwob, D. Taqqu, J.F.C.A. Veloso, Aldo Antognini,
The deuteron is too small, too The radius of the proton has remained a point of debate ever since the spectroscopy of muonic hydrogen indicated a large discrepancy from the previously accepted value. Pohl et al. add an important clue for solving this so-called proton radius puzzle. They determined the charge radius of the deuteron, a nucleus consisting of a proton and a neutron, from the transition frequencies in muonic deuterium. Mirroring the proton radius puzzle, the radius of the deuteron was ...
Tópico(s): Nuclear physics research studies
2016 - American Association for the Advancement of Science | Science
Produção Nacional
Revisado por pares
Nemailla Bonturi, Marina Julio Pinheiro, Paola Monteiro de Oliveira, Eka Rusadze, Tobias Eichinger, Gintare Liudžiūtė, Juliano Sabedotti De Biaggi, Age Brauer, Maido Remm, Everson Alves Miranda, Rodrigo Ledesma‐Amaro, Petri‐Jaan Lahtvee,
Rhodotorula toruloides is a potential chassis for microbial cell factories as this yeast can metabolise different substrates into a diverse range of natural products, but the lack of efficient synthetic biology tools hinders its applicability. In this study, the modular, versatile and efficient Golden Gate DNA assembly system (RtGGA) was adapted to the first basidiomycete, an oleaginous yeast R. toruloides. R. toruloides CCT 0783 was sequenced, and used for the GGA design. The DNA fragments were ...
Tópico(s): Photosynthetic Processes and Mechanisms
2022 - Elsevier BV | Metabolic Engineering Communications
Marc Diepold, F. D. Amaro, Aldo Antognini, F. Biraben, J. M. R. Cardoso, D. S. Covita, A. Dax, S. Dhawan, L. M. P. Fernandes, Adolf Giesen, Andrea L. Gouvea, Thomas Graf, T. W. Hänsch, P. Indelicato, L. Julién, Cheng-Yang Kao, Paul Knowles, F. Kottmann, Éric-Olivier Le Bigot, Yiwei Liu, J. A. M. Lopes, L. Ludhová, C.M.B. Monteiro, F. Mulhauser, Tobias Nebel, F. Nez, Paul Rabinowitz, J.M.F. dos Santos, L. A. Schaller, Karsten Schuhmann, Catherine Schwob, D. Taqqu, J.F.C.A. Veloso, Jan Vogelsang, Randolf Pohl,
Radiative deexcitation (RD) of the metastable 2S state of muonic protium and deuterium atoms has been observed. In muonic protium, we improve the precision on lifetime and population (formation probability) values for the short-lived {\mu}p(2S) component, and give an upper limit for RD of long-lived {\mu}p(2S) atoms. In muonic deuterium at 1 hPa, 3.1 +-0.3 % of all stopped muons form {\mu}d(2S) atoms. The short-lived 2S component has a population of 1.35 +0.57 -0.33 % and a lifetime of {\tau}_short({\mu}d) = 138 +32 - ...
Tópico(s): X-ray Spectroscopy and Fluorescence Analysis
2013 - American Physical Society | Physical Review A
Julian J. Krauth, Karsten Schuhmann, Marwan Abdou Ahmed, F. D. Amaro, Pedro Amaro, F. Biraben, Tzu-Ling Chen, D. S. Covita, A. Dax, Marc Diepold, L. M. P. Fernandes, B. Franke, Sandrine Galtier, Andrea L. Gouvea, J. Götzfried, Thomas Graf, Theodor W. Hänsch, Jens Hartmann, M. Hildebrandt, P. Indelicato, L. Julién, K. Kirch, A. Knecht, Yiwei Liu, Jorge Machado, C.M.B. Monteiro, F. Mulhauser, Boris Naar, Tobias Nebel, F. Nez, J.M.F. dos Santos, J. P. Santos, Csilla I. Szabo, D. Taqqu, J.F.C.A. Veloso, Jan Vogelsang, Andreas Voß, Birgit Weichelt, Randolf Pohl, Aldo Antognini, F. Kottmann,
Abstract The energy levels of hydrogen-like atomic systems can be calculated with great precision. Starting from their quantum mechanical solution, they have been refined over the years to include the electron spin, the relativistic and quantum field effects, and tiny energy shifts related to the complex structure of the nucleus. These energy shifts caused by the nuclear structure are vastly magnified in hydrogen-like systems formed by a negative muon and a nucleus, so spectroscopy of these muonic ...
Tópico(s): Nuclear physics research studies
2021 - Nature Portfolio | Nature
Karen Lebek, Cornelius Senf, David Frantz, José A. F. Monteiro, Tobias Krueger,
Tópico(s): Hydrology and Sediment Transport Processes
2019 - Springer Science+Business Media | Regional Environmental Change
Yang Zhou, Tobias Kaiser, Patrícia Monteiro, Xiangyu Zhang, Marie. S. Van der Goes, Dongqing Wang, Boaz Barak, Menglong Zeng, Chenchen Li, Congyi Lu, Michael F. Wells, Aldo Amaya, Shannon Nguyen, Michael C. Lewis, Neville E. Sanjana, Yongdi Zhou, Mingjie Zhang, Feng Zhang, Zhanyan Fu, Guoping Feng,
Genetic studies have revealed significant overlaps of risk genes among psychiatric disorders. However, it is not clear how different mutations of the same gene contribute to different disorders. We characterized two lines of mutant mice with Shank3 mutations linked to ASD and schizophrenia. We found both shared and distinct synaptic and behavioral phenotypes. Mice with the ASD-linked InsG3680 mutation manifest striatal synaptic transmission defects before weaning age and impaired juvenile social ...
Tópico(s): Neuroscience and Neuropharmacology Research
2015 - Cell Press | Neuron
Produção Nacional
Revisado por pares
Tobias Micklitz, Felipe Monteiro, Alexander Altland,
We analytically study spectral correlations and many body wave functions of a Sachdev-Ye-Kitaev model deformed by a random Hamiltonian diagonal in Fock space. Our main result is the identification of a wide range of intermediate coupling strengths where the spectral statistics is of Wigner-Dyson type, while wave functions are nonuniformly distributed over Fock space. The structure of the theory suggests that such manifestations of nonergodic extendedness may be a prevalent phenomenon in many body ...
Tópico(s): Opinion Dynamics and Social Influence
2019 - American Physical Society | Physical Review Letters
Produção Nacional
Revisado por pares
Carlos Fabrício Assunção da Silva, M C Maia e Silva, Alex Mota dos Santos, Anderson Paulo Rudke, Cristine Vieira do Bonfim, Gabriela Tobias Portis, Pedro Monteiro de Almeida, Maria Beatriz de Santana Coutinho,
To analyse the spatial distribution of rates of COVID-19 cases and its association with socio-economic conditions in the state of Pernambuco, Brazil.
Tópico(s): COVID-19 Pandemic Impacts
2022 - Wiley | Tropical Medicine & International Health
Kristopher M. Kahlig, Thomas H. Rhodes, Michael Pusch, Tobias Freilinger, José Pereira‐Monteiro, Michel D. Ferrari, Arn M. J. M. van den Maagdenberg, Martin Dichgans, Alfred L. George,
Familial hemiplegic migraine type 3 (FHM3) is a severe autosomal dominant migraine disorder caused by mutations in the voltage-gated sodium channel Na(V)1.1 encoded by SCN1A. We determined the functional consequences of three mutations linked to FHM3 (L263V, Q1489K, and L1649Q) in an effort to identify molecular defects that underlie this inherited migraine disorder. Only L263V and Q1489K generated quantifiable sodium currents when coexpressed in tsA201 cells with the human beta(1) and beta(2) accessory ...
Tópico(s): Epilepsy research and treatment
2008 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Inokentijs Josts, Yunyun Gao, Diana C. F. Monteiro, Stephan Niebling, Julius Nitsche, Katharina Veith, Tobias Gräwert, Clément E. Blanchet, Martin A. Schroer, Nils Huse, Arwen R. Pearson, Dmitri I. Svergun, Henning Tidow,
Recent structures of full-length ATP-binding cassette (ABC) transporter MsbA in different states indicate large conformational changes during the reaction cycle that involve transient dimerization of its nucleotide-binding domains (NBDs). However, a detailed molecular understanding of the structural changes and associated kinetics of MsbA upon ATP binding and hydrolysis is still missing. Here, we employed time-resolved small-angle X-ray scattering, initiated by stopped-flow mixing, to investigate ...
Tópico(s): Protein Structure and Dynamics
2019 - Elsevier BV | Structure
Ana Patrícia Fernandes, Diogo Lopes, Sandra Sorte, Alexandra Monteiro, Carla Gama, Johnny Reis, Isilda Menezes, Tobias Osswald, C. Borrego, Miguel Almeida, Luís Mário Ribeiro, D. X. Viegas, Ana Isabel Miranda,
In the last decades, numerous large forest fires have been recorded in Portugal. On 15 and 16 October 2017, seven extreme wildfires events (EWEs) took place in the central region of Portugal. Aiming to contribute to the assessment of the smoke impact of these EWEs, this study estimates their atmospheric emissions using a bottom-up approach with high spatial and temporal resolution. To this end, fire data were used, such as ignition location and time, propagation, burned area, and fuel load and emission ...
Tópico(s): Atmospheric and Environmental Gas Dynamics
2022 - CSIRO Publishing | International Journal of Wildland Fire
Marc Diepold, L. M. P. Fernandes, Jorge Machado, Pedro Amaro, Marwan Abdou‐Ahmed, F. D. Amaro, Aldo Antognini, F. Biraben, Tzu-Ling Chen, D. S. Covita, A. Dax, B. Franke, Sandrine Galtier, Andrea L. Gouvea, J. Götzfried, Thomas Graf, T. W. Hänsch, M. Hildebrandt, P. Indelicato, L. Julién, K. Kirch, A. Knecht, F. Kottmann, Julian J. Krauth, Yiwei Liu, C.M.B. Monteiro, F. Mulhauser, Boris Naar, Tobias Nebel, F. Nez, J. P. Santos, J.M.F. dos Santos, Karsten Schuhmann, Csilla I. Szabo, D. Taqqu, J.F.C.A. Veloso, Andreas Voß, Birgit Weichelt, Randolf Pohl,
Avalanche photodiodes are commonly used as detectors for low energy x-rays. In this work, we report on a fitting technique used to account for different detector responses resulting from photoabsorption in the various avalanche photodiode layers. The use of this technique results in an improvement of the energy resolution at 8.2 keV by up to a factor of 2 and corrects the timing information by up to 25 ns to account for space dependent electron drift time. In addition, this waveform analysis is ...
Tópico(s): X-ray Spectroscopy and Fluorescence Analysis
2015 - American Institute of Physics | Review of Scientific Instruments
Produção Nacional
Revisado por pares
Felipe Monteiro, Masaki Tezuka, Alexander Altland, David A. Huse, Tobias Micklitz,
We generalize Page's result on the entanglement entropy of random pure states to the many-body eigenstates of realistic disordered many-body systems subject to long range interactions. This extension leads to two principal conclusions: first, for increasing disorder the "shells" of constant energy supporting a system's eigenstates fill only a fraction of its full Fock space and are subject to intrinsic correlations absent in synthetic high-dimensional random lattice systems. Second, in all regimes ...
Tópico(s): Quantum and electron transport phenomena
2021 - American Physical Society | Physical Review Letters
F. Nez, Aldo Antognini, F. D. Amaro, F. Biraben, J. M. R. Cardoso, D. S. Covita, A. Dax, S. Dhawan, L. M. P. Fernandes, Adolf Giesen, Thomas Graf, T. W. Hänsch, P. Indelicato, L. Julién, Cheng-Yang Kao, P. Knowles, E. Le Bigot, Yiwei Liu, J. A. M. Lopes, L. Ludhová, C.M.B. Monteiro, F. Mulhauser, Tobias Nebel, P. Rabinowitz, J.M.F. dos Santos, L. A. Schaller, Karsten Schuhmann, Catherine Schwob, D. Taqqu, J.F.C.A. Veloso, F. Kottmann, Randolf Pohl,
It is now recognized that the International System of Units (SI units) will be redefined in terms of fundamental constants, even if the date when this will occur is still under debate. Actually, the best estimate of fundamental constant values is given by a least-squares adjustment, carried out under the auspices of the Committee on Data for Science and Technology (CODATA) Task Group on Fundamental Constants. This adjustment provides a significant measure of the correctness and overall consistency ...
Tópico(s): Atomic and Molecular Physics
2011 - Royal Society | Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences
Randolf Pohl, Aldo Antognini, F. Nez, F. D. Amaro, F. Biraben, J. M. R. Cardoso, D. S. Covita, A. Dax, S. Dhawan, L. M. P. Fernandes, Adolf Giesen, Thomas Graf, T. W. Hänsch, P. Indelicato, L. Julién, Cheng-Yang Kao, Paul Knowles, Éric-Olivier Le Bigot, Yiwei Liu, J. A. M. Lopes, L. Ludhová, C.M.B. Monteiro, F. Mulhauser, Tobias Nebel, Paul Rabinowitz, J.M.F. dos Santos, L. A. Schaller, Karsten Schuhmann, Catherine Schwob, D. Taqqu, J.F.C.A. Veloso, F. Kottmann,
The long quest for a measurement of the Lamb shift in muonic hydrogen is over. Last year we measured the 2S 1/2 F=1 –2P 3/2 F=2 energy splitting (Pohl et al., Nature, 466, 213 (2010)) in μp with an experimental accuracy of 15 ppm, twice better than our proposed goal. Using current QED calculations of the fine, hyperfine, QED, and finite size contributions, we obtain a root-mean-square proton charge radius of r p = 0.841 84 (67) fm. This value is 10 times more precise, but 5 standard deviations smaller, ...
Tópico(s): Advanced Frequency and Time Standards
2011 - NRC Research Press | Canadian Journal of Physics
Tobias Kaiser, Jonathan T. Ting, Patrícia Monteiro, Guoping Feng,
Parvalbumin (PVALB)-expressing fast-spiking interneurons subserve important roles in many brain regions by modulating circuit function and dysfunction of these neurons is strongly implicated in neuropsychiatric disorders including schizophrenia and autism. To facilitate the study of PVALB neuron function we need to be able to identify PVALB neurons in vivo. We have generated a bacterial artificial chromosome (BAC) transgenic mouse line expressing the red fluorophore tdTomato under the control of endogenous ...
Tópico(s): Genetics and Neurodevelopmental Disorders
2015 - Elsevier BV | Neuroscience
Johannes Schmoellerl, Inês Amorim Monteiro Barbosa, Martina Minnich, Florian Andersch, Leonie Smeenk, Marije Havermans, Thomas Eder, Tobias Neumann, Julian Jude, Michaela Fellner, Anja Ebert, Monika Steininger, Ruud Delwel, Florian Grebien, Johannes Zuber,
Abstract Chromosomal rearrangements involving the MDS1 and EVI1 complex locus (MECOM) on chromosome 3q26 define an aggressive subtype of acute myeloid leukemia (AML) that is associated with chemotherapy resistance and dismal prognosis. Established treatment regimens commonly fail in these patients, therefore, there is an urgent need for new therapeutic concepts that will require a better understanding of the molecular and cellular functions of the ecotropic viral integration site 1 (EVI1) oncogene. ...
Tópico(s): Genomics and Chromatin Dynamics
2022 - Elsevier BV | Blood
Miyu Moriyama, Carolina Lucas, Valter Silva Monteiro, Akiko Iwasaki, Nicholas Chen, Mallery I. Breban, Anne M. Hahn, Kien Pham, Tobias R. Koch, Chrispin Chaguza, Irina Tikhonova, Christopher Castaldi, Shrikant Mane, Bony De Kumar, David Ferguson, Nicholas Kerantzas, David R. Peaper, Marie L. Landry, Wade L. Schulz, Chantal B. F. Vogels, Nathan D. Grubaugh,
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) possess mutations that confer resistance to neutralizing antibodies within the Spike protein and are associated with breakthrough infection and reinfection. By contrast, less is known about the escape from CD8+ T cell-mediated immunity by VOC. Here, we demonstrated that all SARS-CoV-2 VOCs possess the ability to suppress major histocompatibility complex class I (MHC-I) expression. We identified several viral genes ...
Tópico(s): vaccines and immunoinformatics approaches
2023 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Carlos J. P. Monteiro, Sónia A. C. Carabineiro, Tobias Lauterbach, Christoph Hubbert, A. Stephen K. Hashmi, José L. Figueiredo, Mariette M. Pereira,
Abstract ( S )‐6‐(4‐(Methoxycarbonyl)phenyl)‐1,1′‐bis‐2‐naphthol, a chiral 1,1′‐bis‐2‐naphthol (BINOL) derivative, was prepared via Suzuki C−C coupling and immobilized onto diamine‐functionalized multiwalled carbon nanotubes. The BINOL was first derivatized with a carboxylic acid, capable of forming an amide linkage with the amine–carbon nanotube modified surface. The 4‐methoxyphenylboronic acid was replaced by 3‐fluoro‐4‐(methoxycarbonyl)phenylboronic acid and ( S )‐6‐(3‐fluoro‐4‐(methoxycarbonyl)phenyl)‐ ...
Tópico(s): Covalent Organic Framework Applications
2015 - Wiley | ChemNanoMat
Produção Nacional
Revisado por pares
Vitória Tobias‐Santos, Lupis Ribeiro, Amanda Fraga, Cíntia Monteiro de Barros, Eldo Campos, Jorge Moraes, Marcio Fontenele, Helena Araujo, Natália Martins Feitosa, Carlos Logullo, Rodrigo Nunes da Fonseca,
Summary: Chelicerates, which include spiders, ticks, mites, scorpions, and horseshoe crabs, are members of the phylum Arthropoda. In recent years, several molecular experimental studies of chelicerates have examined the embryology of spiders; however, the embryology of other groups, such as ticks (Acari: Parasitiformes), has been largely neglected. Ticks and mites are believed to constitute a monophyletic group, the Acari. Due to their blood‐sucking activities, ticks are also known to be vectors ...
Tópico(s): Study of Mite Species
2013 - Wiley | genesis
Produção Nacional
Revisado por pares
Emanuel Peinke, Tobias Sattler, Guilherme Monteiro Torelly, P. L. Souza, Sylvain Perret, J. Bleuse, Julien Claudon, Willem L. Vos, Jean‐Michel Gérard,
Abstract We review recent studies of cavity switching induced by the optical injection of free carriers in micropillar cavities containing quantum dots. Using the quantum dots as a broadband internal light source and a streak camera as detector, we track the resonance frequencies for a large set of modes with picosecond time resolution. We report a record-fast switch-on time constant (1.5 ps) and observe major transient modifications of the modal structure of the micropillar on the 10 ps time scale: ...
Tópico(s): Neural Networks and Reservoir Computing
2021 - Springer Nature | Light Science & Applications
Aldo Antognini, Randolf Pohl, F. D. Amaro, F. Biraben, J. M. R. Cardoso, D. S. Covita, A. Dax, S. Dhawan, L. M. P. Fernandes, A. Giesen, Andrea L. Gouvea, Thomas Graf, T. W. Hänsch, M. Hildebrandt, P. Indelicato, L. Julien, Cheng-Yang Kao, K. Kirch, P. Knowles, E.-O. Le Bigot, Yiwei Liu, J. A. M. Lopes, L. Ludhová, C.M.B. Monteiro, F. Mulhauser, Tobias Nebel, F. Nez, P. Rabinowitz, J.M.F. dos Santos, L.A. Schaller, K. Schuhmann, C. Schwob, D. Taqqu, J.F.C.A. Veloso, Andreas Voß, F. Kottmann,
By means of pulsed laser spectroscopy applied to muonic hydrogen (μ− p) we have measured the 2S F = 1 1/2 − 2PF = 2 3/2 transition frequency to be 49881.88(76) GHz. By comparing this measurement with its theoretical prediction based on bound-state QED we have determined a proton radius value of rp = 0.84184 (67) fm. This new value is an order of magnitude preciser than previous results but disagrees by 5 standard deviations from the CODATA and the electronproton scattering values. An overview of the present ...
Tópico(s): Particle accelerators and beam dynamics
2011 - Elsevier BV | Physics Procedia