William S. Helton, Todd D. Hollander, Joel S. Warm, Lloyd D. Tripp, Kelley Parsons, Gerald Matthews, William N. Dember, Raja Parasuraman, Peter A. Hancock,
Abstract Transcranial Doppler sonography (TCD) and transcranial cerebral oximetry (TCCO) measures of cerebral blood flow velocity and oxygenation levels were collected during an abbreviated 12-min vigilance task. Both the TCD and TCCO measures showed higher levels of cerebral vascular activity in the right than in the left cerebral hemisphere; the cerebral laterality of vigilance occurs in an abbreviated task. Although there was a significant decline in performance over time, there was no significant ...
Tópico(s): Heart Rate Variability and Autonomic Control
2007 - Taylor & Francis | Journal of Clinical and Experimental Neuropsychology
William S. Helton, Todd D. Hollander, Joel S. Warm, Gerald Matthews, William N. Dember, Matthew Wallaart, Gerald Beauchamp, Raja Parasuraman, Peter A. Hancock,
Robertson, Manly, Andrade, Baddeley, and Yiend (1997) have proposed that detection failures in vigilance tasks result from a ‘mindless’ withdrawal of attentional effort from the monitoring assignment. To explore that view, they modified the traditional vigilance task, in which observers make button‐press responses to signify the detection of rarely occurring critical signals, to one in which button‐press responses acknowledge frequently occurring non‐signal events and response withholding signifies ...
Tópico(s): Mind wandering and attention
2005 - Wiley | British Journal of Psychology
Ludwig Schaaf, Jörg Trojan, Todd E. Helton, K. H. Usadel, James A. Magner,
Abstract The aims of the present study were to determine the influence of brief subclinical hypothyroidism on the isoforms of serum thyrotropin (TSH) and to examine the net charge of TSH in different metabolic states. Sera were obtained from euthyroid subjects ( n =7) and from patients with subclinical hypothyroidism ( n =8) before and 30 min after the intravenous administration of 200 μg thyrotropin-releasing hormone (TRH). The TSH from human pituitary extracts (IRP 68/38), basal and TRH-stimulated serum ...
Tópico(s): Adrenal Hormones and Disorders
1995 - Bioscientifica | Journal of Endocrinology
Todd E. Helton, James A. Magner,
Hypothyroid animals secrete not only more TSH, but also qualitatively different TSH, with altered oligosaccharides. To explore the cellular mechanism of oligosaccharide modulation by thyroid status, 40 mice were treated without or with propylthiouracil (PTU), and pituitaries were removed after 1, 2, 3, 4, and 6 weeks. Serum T4 levels confirmed that mice receiving PTU were hypothyroid even after only 1 week. Thyrotrophs and corticotrophs were identified in 5-microns thick pituitary slices using immunocytochemistry; ...
Tópico(s): Growth Hormone and Insulin-like Growth Factors
1994 - Oxford University Press | Endocrinology
Todd E. Helton, James A. Magner,
Hypothyroid patients and mice have been shown to have circulating TSH that is more highly sialylated than their euthyroid counterparts. To learn about the underlying cellular mechanisms responsible for this increased sialylation of TSH, we used in situ hybridization to examine the beta-galactoside alpha-2,6-sialyltransferase (STase) mRNA content in thyrotrophs and corticotrophs of euthyroid and hypothyroid mice. Mice were treated with or without 0.05% propylthiouracil for 1, 2, 3, 4, or 6 weeks, ...
Tópico(s): Hypothalamic control of reproductive hormones
1994 - Oxford University Press | Endocrinology
In this study, the glutamate receptor agonist, NMDA, was used to induce epileptic seizures in order to compare the expression of the immediate early gene (IEG) products, Fos and Fos-related antigens (Fras), with the opioid peptides, dynorphin (DYN) and leu5-enkephalin (LE), in the rat hippocampus. Fos-ir and Fra-ir were observed in the dentate granule cells and nonpyramidal cells within the hippocampal formation at 1 h, and in all hippocampal cells and fields, 3 h following injection of NMDA into the ...
Tópico(s): Neuropeptides and Animal Physiology
1993 - Elsevier BV | Molecular and Cellular Neuroscience
Roger P. Dilts, Todd E. Helton, Jaqueline F. McGinty,
The influence of the mesencephalic dopaminergic projections on the neurons within the basal forebrain and prefrontal cortex is not well understood although it has been intensely investigated. The purpose of this study was to evaluate the expression of Fos-like and FRA-like (Fos Related Antigens) immunoreactivity (IR) as a qualitative and quantitative marker of neuronal activity within the mesolimbic and mesostriatal dopamine terminal fields. Following the administration of apomorphine (5.0 mg/kg S. ...
Tópico(s): Receptor Mechanisms and Signaling
1993 - Wiley | Synapse
Todd E. Helton, James B. Daunais, J.F. McGinty,
Rats were treated with escalating doses of cocaine until they experienced a convulsion and were euthanized 1 or 3 h after the last injection. Quantitative in situ hybridization histochemistry revealed that c-fos and zif/268 mRNAs were induced at 1 h in many limbic structures and declined 3 h after cocaine-induced convulsions. Preprodynorphin and preproenkephalin signals increased in many of the same structures 3 h, but not 1 h, after cocaine-induced convulsions.
Tópico(s): Receptor Mechanisms and Signaling
1993 - Elsevier BV | Molecular Brain Research
Todd E. Helton, James A. Magner,
Our goal was to learn about the cellular mechanism(s) responsible for the increased sialylation of thyroid-stimulating hormone (TSH) during hypothyroidism. We used in situ hybridization to examine the β-galactoside α-2,3-sialyltransferase mRNA content in thyrotrophs and corticotrophs of euthyroid and hypothyroid [propylthiouracil (PTU)-treated] mice. The α-2,3-sialyltransferase mRNA level was 66, 70,296, and 223% higher in hypothyroid thyrotrophs than in euthyroid thyrotrophs after mice received PTU ...
Tópico(s): Growth Hormone and Insulin-like Growth Factors
1995 - Mary Ann Liebert, Inc. | Thyroid
Journal Article Sialyltransferase messenger ribonucleic acid increases in thyrotrophs of hypothyroid mice: an in situ hybridization study Get access T E Helton, T E Helton 1Department of Medicine, East Carolina University School of Medicine, Greenville, North Carolina 27858-4354. Search for other works by this author on: Oxford Academic Google Scholar J A Magner J A Magner 1Department of Medicine, East Carolina University School of Medicine, Greenville, North Carolina 27858-4354. Search for other ...
Tópico(s): Diabetes and associated disorders
1994 - Oxford University Press | Endocrinology
L.C. Bernard, F.J. Helton, R.W. Moore, T. N. Todd,
Simple scaling laws for the ideal-MHD β-limit (βc) as a function of plasma shape parameters (inverse aspect ratio ε, elongation κ, and triangularity δ) in the range covered by recent high-β (≤ 4.5%) experiments in Doublet III are derived. β-limits are obtained by optimizing the current profile. A large class of profiles is considered. β-limits are presented for a single Gaussian profile as they do not significantly improve with more elaborate profiles. Excluding the region dominated by sawtooth activity, ...
Tópico(s): Ionosphere and magnetosphere dynamics
1983 - IOP Publishing | Nuclear Fusion
J.T. Bell, D.M. Helton, Tommie G. Rogers,
... sulfate from 25.deg. to 374.deg.Jimmy Todd Bell, Dennis M. Helton, and Tommie G. RogersCite this: J. Chem. Eng. ...
Tópico(s): Water Quality and Resources Studies
1970 - American Chemical Society | Journal of Chemical & Engineering Data
Hypothyroid animals secrete not only more TSH, but also qualitatively different TSH, with altered oligosaccharides. To explore the cellular mechanism of oligosaccharide modulation by thyroid status, 40 mice were treated without or with propylthiouracil (PTU), and pituitaries were removed after 1, 2, 3, 4, and 6 weeks. Serum T4 levels confirmed that mice receiving PTU were hypothyroid even after only 1 week. Thyrotrophs and corticotrophs were identified in 5-microns thick pituitary slices using immunocytochemistry; ...
Tópico(s): Erythrocyte Function and Pathophysiology
1994 - Oxford University Press | Endocrinology
Todd Pesek, Lonnie R. Helton, Murali Nair,
Tópico(s): Empathy and Medical Education
2006 - Springer Science+Business Media | EcoHealth
Kiera L. O’Donnell, Emily S. Bernhardt, Xi Yang, R. E. Emanuel, Marcelo Ardón, Manuel Lerdau, Alex K. Manda, Anna Braswell, Todd K. BenDor, Eric C. Edwards, Elizabeth Frankenberg, Ashley M. Helton, John S. Kominoski, Amy E. Lesen, Lindsay Naylor, Gregory B. Noe, Kate Tully, Elliott White, Justin P. Wright,
The United States (U.S.) coastal plain is subject to rising sea levels, land subsidence, more severe coastal storms, and more intense droughts. These changes lead to inputs of marine salts into freshwater-dependent coastal systems, creating saltwater intrusion. The penetration of salinity into the coastal interior is exacerbated by groundwater extraction and the high density of agricultural canals and ditches throughout much of the rural U.S. landscape. Together saltwater intrusion and sea level ...
Tópico(s): Geology and Paleoclimatology Research
2024 - Elsevier BV | Anthropocene
William S. Helton, Todd D. Hollander, Joel S. Warm, Gerald Matthews, William N. Dember, Matthew Wallaart, Gerald Beauchamp, Raja Parasuraman,
Robertson et al. (1997) have proposed that detection failures in vigilance tasks result from a “mindless” withdrawal of attentional effort from the monitoring assignment. To explore that view, they modified the traditional vigilance task in which observers make button-press responses to signify the detection of rarely occurring critical signals to one in which button-press responses acknowledge frequently occurring non-signal events and response-withholding signifies signal detection. This modification ...
Tópico(s): EEG and Brain-Computer Interfaces
2003 - SAGE Publishing | Proceedings of the Human Factors and Ergonomics Society Annual Meeting
Joseph B. Lesnak, Alexis Fahrion, Amber Helton, Lynn Rasmussen, Megan Andrew, Stefanie Cunard, Michaela Huey, Austin Kreber, Joseph W. Landon, Travis Siwiec, Kenan Todd, Laura Frey Law, Kathleen A. Sluka,
Resistance training-based exercise is commonly prescribed in the clinic for the treatment of chronic pain. Mechanisms of aerobic exercise for analgesia are frequently studied, while little is known regarding resistance training mechanisms. We developed a resistance training model in mice and hypothesized resistance training would protect against development of muscle pain, mediated through the activation of androgen receptors. Activity-induced muscle hyperalgesia was produced by 2 injections of ...
Tópico(s): Muscle metabolism and nutrition
2022 - Lippincott Williams & Wilkins | Pain
Heather L. Helton, Rhonda E. Ries, Todd A. Alonzo, Robert B. Gerbing, Lisa R. Treviño, Jason E. Farrar, Jaime M. Guidry Auvil, Tanja M. Davidsen, Patee Gesuwan, Donna M. Muzny, Alan S. Gamis, Janet Franklin, David A. Wheeler, Malcolm A. Smith, Daniela S. Gerhard, R.J. Arceci, Soheil Meshinchi,
Abstract Abstract 125 Despite identification of genomic alterations in AML, clinically actionable variants are limited. Further, mutations identified in adult AML are less frequent or not found in childhood AML. TARGET AML initiative, a collaboration between National Cancer Institute Office of Cancer Genomics (NCI/OCG) and Children's Oncology Group (COG) provided resources to perform multi-platform analysis of a large number of pediatric AML cases in order to identify therapeutic targets in childhood ...
Tópico(s): HIV/AIDS drug development and treatment
2012 - Elsevier BV | Blood
Tricia A. Babcock, Todd E. Novak, Evan Ong, David H. Jho, W. Scott Helton, N. Joseph Espat,
Background. The role of ω-3 fatty acids (FA) as anti-inflammatory agents involves the inhibition of macrophage (Mφ) cytokine production, but the mechanisms involved are not well defined. The effects of ω-3 FA on the transcription and translation of cyclooxygenase-2 (COX-2), the production of prostaglandin E2 (PGE2), and the production of interleukin-10 (IL-10) were investigated as potential mechanisms for the down-regulation of lipopolysaccharide (LPS)-induced tumor necrosis factor-α production. Methods. ...
Tópico(s): Eicosanoids and Hypertension Pharmacology
2002 - Elsevier BV | Journal of Surgical Research
Todd E. Novak, Tricia A. Babcock, David H. Jho, W. Scott Helton, N. Joseph Espat,
ω-3 Fatty acid (FA) emulsions reduce LPS-stimulated murine macrophage TNF-α production, but the exact mechanism has yet to be defined. The purpose of this study was to determine the mechanism for ω-3 FA inhibition of macrophage TNF-α production following LPS stimulation. RAW 264.7 cells were pretreated with isocaloric emulsions of ω-3 FA (Omegaven), ω-6 FA (Lipovenos), or DMEM and subsequently exposed to LPS. IκB-α and phospho-IκB-α were determined by Western blotting. NF-κB binding was assessed using ...
Tópico(s): Fatty Acid Research and Health
2003 - American Physical Society | AJP Lung Cellular and Molecular Physiology
Todd A. Carter, Jennifer A. Greenhall, Shigeo Yoshida, Sebastian Fuchs, Robert Helton, Anand Swaroop, David J. Lockhart, Carrolee Barlow,
Progressive neurological dysfunction is a key aspect of human aging. Because of underlying differences in the aging of mice and humans, useful mouse models have been difficult to obtain and study. We have used gene-expression analysis and polymorphism screening to study molecular senescence of the retina and hippocampus in two rare inbred mouse models of accelerated neurological senescence (SAMP8 and SAMP10) that closely mimic human neurological aging, and in a related normal strain (SAMR1) and an ...
Tópico(s): interferon and immune responses
2005 - BioMed Central | Genome biology
Suneel K. Kandagatla, Todd Steven Mack, S.J. Simpson, Jill Sollenberger, Eric Helton, Gregory M. Raner,
The purpose of this study was to probe active site structure and dynamics of human cytochrome P4502E1 and P4502A6 using a series of related short chain fatty aldehydes. Binding efficiency of the aldehydes was monitored via their ability to inhibit the binding and activation of the probe substrates p-nitrophenol (2E1) and coumarin (2A6). Oxidation of the aldehydes was observed in reactions with individually expressed 2E1, but not 2A6, suggesting alternate binding modes. For saturated aldehydes the ...
Tópico(s): Analytical Chemistry and Chromatography
2014 - Elsevier BV | Chemico-Biological Interactions
Soheil Meshinchi, Rhonda E. Ries, Lisa R. Treviño, Oliver Hampton, Todd A. Alonzo, Jason E. Farrar, Jaime M. Guidry Auvil, Tanja M. Davidsen, Patee Gesuwan, Donna M. Muzny, Alan S. Gamis, Heather L. Helton, David A. Wheeler, Malcolm A. Smith, Daniela S. Gerhard, R.J. Arceci,
Abstract Abstract 123 Comprehensive cataloguing of somatic changes in acute myeloid leukemia (AML) has revealed novel molecular pathways that contribute to the development and progression of the disease, however many lack prognostic significance. The challenge that lies ahead is to understand how these molecular changes relate to transcription and protein deregulation to influence treatment responses and outcomes. Also, some mutations found in adult AML are detected at lower frequency or not at all ...
Tópico(s): Cancer Genomics and Diagnostics
2012 - Elsevier BV | Blood
... Michael B. Flinn, Erica A. Garcia, Ashley M. Helton, Tamara K. Harms, Shufang Jia, Jeremy B. Jones, ... BEAULIEU, AMY J. BURGIN, CHELSEA CRENSHAW, ASHLEY M. HELTON, LAURA JOHNSON, JEFF MERRIAM, B. R. NIEDERLEHNER, JONATHAN ... doi.org/10.1899/08-170.1M. Jason Todd, George Vellidis, R. Richard Lowrance, Catherine M. Pringle ...
Tópico(s): Aquatic Invertebrate Ecology and Behavior
1997 - University of Chicago Press | Journal of the North American Benthological Society
Amar Yeware, Angelica M. Helton, Yicheng Dong, Cheng Dong, Justin R. Pritchard, Shin Mineishi, Kentaro Minagawa, Todd D. Schell, Daniel J. Hayes,
Fourth-generation chimeric antigen receptor (CAR) T-cells, using costimulatory domains to drive the co-expression of transgenic key cytokines, have been shown to significantly enhance the efficacy of CAR T cell therapy in the treatment of solid tumors. Recent studies identified several miRNAs, such as miR-34a-5p, miR-181a-5p, miR-218–5p and miR-433–3p, that are involved in regulating cancer cell proliferation, apoptosis, and metastasis. However, controlled delivery of miRNA to non-hepatic tissue ...
Tópico(s): Extracellular vesicles in disease
2023 - Elsevier BV | Biochemical Engineering Journal
Jackson R. Webster, Judy L. Meyer,
... Walter K. Dodds, Hannah M. Fazekas, Ashley M. Helton, Penny J. Johnes, Sherri L. Johnson, Jeremy B. ... Pedro J. Torres, William H. McDowell, Alan Covich, Todd Crowl, and Omar Pérez-Reyes When the rainforest ... Thomas G. Whitham, Nashelly Meneses, Posy E. Busby, Todd Wojtowicz, Audrey C. Ford, Kenneth J. Adams, Jane ...
Tópico(s): Freshwater macroinvertebrate diversity and ecology
1997 - University of Chicago Press | Journal of the North American Benthological Society
Daniela S. Gerhard, Lukas Wagner, Elise A. Feingold, Carolyn M. Shenmen, Lynette Grouse, Greg Schuler, Steven L. Klein, Susan Old, Rebekah S. Rasooly, Peter J. Good, Mark S. Guyer, Allison M. Peck, Jeffery G. Derge, David J. Lipman, Francis S. Collins, Wonhee Jang, Stephen T. Sherry, Mike Feolo, Leonie Misquitta, Eduardo Lee, Kirill E. Rotmistrovsky, Susan F. Greenhut, Carl F. Schaefer, Kenneth H. Buetow, Tom I. Bonner, David Haussler, Jim Kent, Mark Diekhans, Terrence S. Furey, Michael R. Brent, Christa Prange, Kirsten Schreiber, Nicole Shapiro, Narayan Bhat, Ralph F. Hopkins, Florence Hsie, Tom Driscoll, Marcelo B. Soares, Maria F. Bonaldo, T.L. Casavant, Todd E. Scheetz, Michael Brownstein, Ted B. Usdin, Toshiyuki Shiraki, Piero Carninci, Yulan Piao, Dawood B. Dudekula, Minoru S.H. Ko, Koichi Kawakami, Yutaka Suzuki, Sumio Sugano, C. E. Gruber, M. Smith, Blake A. Simmons, Troy Moore, Richard Waterman, Stephen L. Johnson, Yijun Ruan, Chia Lin Wei, Sinnakaruppan Mathavan, Preethi H. Gunaratne, Jiaqian Wu, Angela Garcia, Stephen W. Hulyk, Edwin Fuh, Ye Yuan, Anna Sneed, Carla Kowis, Anne V. Hodgson, Donna M. Muzny, John D. McPherson, Richard A. Gibbs, Jessica Fahey, Erin Helton, Mark Ketteman, Anuradha Madan, Stephanie Rodrigues, Amy Sanchez, Michelle Whiting, Anup Madan, Alice Young, Keith Wetherby, Stephen J. Granite, Peggy N. Kwong, Charles P. Brinkley, Russell L. Pearson, Gerard G. Bouffard, Robert W. Blakesly, Eric D. Green, Mark Dickson, Álex Rodríguez, Jonathan Wood, Jeremy Schmutz, R Myers, Yaron S.N. Butterfield, Malachi Griffith, Obi L. Griffith, Martin Krzywinski, Nancy Liao, Ryan Morrin, Diana Palmquist, Anca S. Petrescu, Ursula Skalska, Duane E. Smailus, Jeff Stott, Angelique Schnerch, Jacqueline E. Schein, Steven J.M. Jones, Robert A. Holt, Ágnes Baross, Marco A. Marra, Sandra W. Clifton, Kathryn A. Makowski, Stephanie Bosak, Joel A. Malek,
The National Institutes of Health's Mammalian Gene Collection (MGC) project was designed to generate and sequence a publicly accessible cDNA resource containing a complete open reading frame (ORF) for every human and mouse gene. The project initially used a random strategy to select clones from a large number of cDNA libraries from diverse tissues. Candidate clones were chosen based on 5′-EST sequences, and then fully sequenced to high accuracy and analyzed by algorithms developed for this project. ...
Tópico(s): Gene expression and cancer classification
2004 - Cold Spring Harbor Laboratory Press | Genome Research
Robert L. Strausberg, Elise A. Feingold, Lynette Grouse, Jeffery G. Derge, Richard D. Klausner, Francis S. Collins, Lukas Wagner, Carolyn M. Shenmen, Gregory D. Schuler, Stephen F. Altschul, Barry R. Zeebèrg, Kenneth H. Buetow, Carl F. Schaefer, Narayan Bhat, Ralph F. Hopkins, Heather Jordan, Troy Moore, Steve I Max, Jun Wang, Florence Y. Hsieh, Luda Diatchenko, Kate Marusina, Andrew Farmer, Gerald M. Rubin, Ling Hong, Mark Stapleton, Marcelo B. Soares, Maria F. Bonaldo, T.L. Casavant, Todd E. Scheetz, Michael Brownstein, Ted B. Usdin, Toshiyuki Shiraki, Piero Carninci, Christa Prange, Sam S Raha, Naomi A Loquellano, Garrick Peters, Rick D Abramson, Sara J Mullahy, Stephanie Bosak, Paul McEwan, Kevin McKernan, Joel A. Malek, Preethi H. Gunaratne, Stephen Richards, Kim C. Worley, Sarah Hale, Angela Garcia, Stephen W. Hulyk, Debbie K Villalon, Donna M. Muzny, Erica Sodergren, Xiuhua Lu, Richard A. Gibbs, Jessica Fahey, Erin Helton, Mark Ketteman, Anuradha Madan, Stephanie Rodrigues, Amy Sanchez, Michelle Whiting, Anup Madan, Alice Young, Yuriy Shevchenko, Gerard G. Bouffard, Robert W. Blakesley, Jeffrey W. Touchman, Eric D. Green, Mark Dickson, Álex Rodríguez, Jonathan Wood, Jeremy Schmutz, R Myers, Yaron S N Butterfield, Martin Krzywinski, Ursula Skalska, Duane E. Smailus, Angelique Schnerch, Jacqueline E. Schein, Steven J.M. Jones, Marco A Marra,
The National Institutes of Health Mammalian Gene Collection (MGC) Program is a multiinstitutional effort to identify and sequence a cDNA clone containing a complete ORF for each human and mouse gene. ESTs were generated from libraries enriched for full-length cDNAs and analyzed to identify candidate full-ORF clones, which then were sequenced to high accuracy. The MGC has currently sequenced and verified the full ORF for a nonredundant set of >9,000 human and >6,000 mouse genes. Candidate full-ORF clones ...
Tópico(s): RNA and protein synthesis mechanisms
2002 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Todd D. Hollander, William S. Helton, Lloyd D. Tripp, Kelley Parsons, Joel S. Warm, Gerald Matthews, William N. Dember, Raja Parasuraman,
Transcranial Doppler sonography (TCD) and transcranial cerebral oximetry (TCCO) measures of blood flow and oxygenization levels in the brain were collected while observers performed an abbreviated 12 min vigilance task designed by Temple et al. (2000) to serve as an analog to more traditional long-duration vigils. Both measures showed higher levels of cerebral vascular activity in the right as compared to the left cerebral hemisphere indicating that the overall level of performance in the abbreviated ...
Tópico(s): Optical Imaging and Spectroscopy Techniques
2003 - SAGE Publishing | Proceedings of the Human Factors and Ergonomics Society Annual Meeting
Michael F. Ochs, Jason E. Farrar, Michael Considine, Rhonda E. Ries, Lisa R. Treviño, Todd A. Alonzo, Jaime Guidry-Auvil, Tanja M. Davidsen, Patee Gesuwan, Donna M. Muzny, Alan S. Gamis, David A. Wheeler, Heather L. Helton, Malcolm A. Smith, Daniela S. Gerhard, Soheil Meshinchi, R.J. Arceci,
Abstract Abstract 1287 The NCI-directed TARGET AML initiative has provided an opportunity to evaluate the genomic, transcriptomic and epigenomic patterns of large numbers of pediatric patients with newly diagnosed and relapsed AML with the goal of identifying distinctive changes in pathways that are prognostic or can be therapeutically targeted. Genomic sequencing has revealed an important, but limited number of gene mutations, suggesting that epigenetic alterations may be required to explain the ...
Tópico(s): Acute Myeloid Leukemia Research
2012 - Elsevier BV | Blood