Andrew Robson, Phil Yates, William Morrey, John Hester, Barney Spender, Helen Studd, DJM, Patricia Davies, Adam Sherwin Media Reporter, Sarah Potter, Simon Barnes, Neil Inkley, R. H. L. Randall, Graham Searjeant and John Ashworth, Paul Hoggart, Martin Richards, Richard Hobson, Ivo Tennant, Michael Evans Defence Editor, Philip Howard, Michael Mander, David Chater, Penny Wark, Nic Hopkins, Lynne Truss, Thomas Brentwood, Valerie Elliott Countryside Editor and Patrick Barkham, Patrick Barkham, Jeremy Whittle, Kevin Eason, Heather Neill, Shyam Bhatia, John Thicknesse, Ben Webster Transport Correspondent, Pat Gibson, Valerie Elliott Countryside Editor, Philip Whitaker, Jennai Cox Fitness Editor, Anthony Browne, Roger Gibbeson, Director, Debra Craine, Shirley English, Rory Watson, Norman Harris, Tim Reid, Sanjida O'Connell, Richard Ford Home Correspondent, Michael Tillotson, John Chelmsford, Miranda Ingram, Charles Bremner, Helen Rumbelow, Stephen Collins, Matt Dickinson Chief Football Correspondent, Stuart Sime, Angela Jameson, Simon Tait, Emma Thompson, Dr Thomas Stuttaford, Margaret Cook and Phill Robinson, Vanora Bennett, David Lister, Lisa Armstrong, Neil Harman, Mark Henderson Science Correspondent, John Hopkins, Christopher Martin-Jenkins, Gabriella Gamini, Geoffrey Dean, Roge Howard, Raymond Keene, Adam Sage, Sean MacAulay, Matt Dickinson, Sara Curtis, Neville Scott, Colin Coventry, Richard Owen, John Carr, Roger Boyes, R. G. D. Small, Mark Saxon, Jack Gillon, Emily Davies, Stewart Tendler, A. D. Harris, Philip August, Phil Robinson, David Hands Rugby Correspondent, Carolyn Asome, Graham Keeley and Stewart Tendler Crime Correspondent, John Allison, William Rees-Mogg, Joanna Pitman, David Lawrenson and Peter Wilson, Philip Webster Political Editor, Melissa Kite Political Correspondent, Terence Morris, Jane Shilling, Mel Webb, Mike Rosewell, Margaret Cook, Jennifer Hall, George Caulkin, Michael Austin, Ian Headley, Alan Lee, Peter Riddell, Lea Paterson Economics Editor, David Charter Chief Political Correspondent, Lea Paterson, Crispian Portsouth, Ashling O'Connor, Benedict Nightingale, Dr Thomas Stuttaford, Richard Morrison, H. A. Thomas, Valerie Grove, Abigail Rayner, Anne Spackman Property Editor and Valerie Eillott Countryside Editor, David Lovibond and Robin Young, Owen Slot, Robbie Millen, Roma Felstein, Jenny Davey, David Robertson, Giles Whiting, John Watson, David Lister Ireland Correspondent,
... is over. That is the gospel according to Tomas Maier, designer for Bottega Veneta. Lisa Armstrong finds herself ...
2002 - Gale Group | TDA
Maria Grandoch, Ulrich Flögel, Sam Virtue, Julia K. Maier, Tomáš Jeleník, Christina Kohlmorgen, Kathrin Feldmann, Yanina Ostendorf, Tamara R. Castañeda, Zhou Zhou, Yu Yamaguchi, Emmani B. M. Nascimento, Vivekananda Gupta Sunkari, Christine Goy, Martina Kinzig, Fritz Sörgel, Paul L. Bollyky, Patrick Schrauwen, Hadi Al‐Hasani, Michael Roden, Susanne Keipert, António Vidal-Puig, Martin Jastroch, Judith Haendeler, Jens W. Fischer,
Therapeutic increase in brown adipose tissue (BAT) thermogenesis is of great interest, as BAT activation counteracts obesity and insulin resistance. Hyaluronan (HA) is a glycosaminoglycan, found in the extracellular matrix, that is synthesized by HA synthases (HAS1, HAS2, and HAS3) from sugar precursors and accumulates in diabetic conditions. Its synthesis can be inhibited by the small molecule 4-methylumbelliferone (4-MU). Here we show that inhibition of HA synthesis by 4-MU or genetic deletion of ...
Tópico(s): Cardiovascular Disease and Adiposity
2019 - Nature Portfolio | Nature Metabolism
Giles Smith, Andrew Robson, Janice Turner, Phil Yates, Christina Hardyment, Dr John Murray, Jon Ashworth, Pippa Holt, Charles Darwin, Joanna Hunter, Robert Dawson Scott, Donald MacGillivray, Robert Cole, Bel Mooney, Lawrence T. Roach, Greg Hurst Political Correspondent, Gary Duncan, Jane MacQuitty, Janet Ames, Magnus Linklater, Simon Hills, Jenny Agutter, Nicholas Wapshott Philip Webster and David Charter, Robert Thicknesse, Paul Hoggart, Mark Souster, Richard Owen and Carl Mortished, Emma Haughton, David Rhys Jones, John Mulvey, Philip Howard, Hannah Betts, James Bone, Nic Hopkins, Alexandra Frean Social Affairs Correspondent, Elizabeth Judge, Andrew Nicol, Lucia Van Der Post, Patience Wheatcroft, Business Editor, GS, Ginny Dougary, Martyn Palmer Portrait Michael Lewis, Patrick Barkham, John Bungey, Kevin Eason, Nigel Hawkes and Mark Henderson, Ask Aggie, Amon Cohen, Duncan Farmer, Sam Lister, Giles Coren, Ruth Kennedy, Edward Bugler, Mark Griffiths, Edna S. Weiss, Barry Lewis, Vinny Lee, MG, Mark Abley, Katherine Swift, Dave Robinson, Anthony Browne, Jack Malvern, Dominic Walsh, Tom Bawden, James Doran Wall Street Correspondent, Abigail Hofman, Mike Pattenden, Victoria Segal, Leon Marks, Dave Rouse, Joe Morgan, Grainne Gilmore, Dr Jane Collins, Francis Churchill, Rankin, Nigel Williamson, Dan Sabbagh, Andrew Drummond and Nigel Hawkes, Dalya Alberge Arts Correspondent, Hilly Janes, Editor, Body&soul, James Sharpe, MM, Tom Gatti, Gabriel Rozenberg and Greg Hurst, Jo Morris, Stephen Farrell, Steve Harries, Ken Thornber, M. H. Love, Helen Dunmore, Nick Wyke, Anselm Kuhn, Doctor Copperfield, Juliette Kellow, Valerie Elliott Consumer Editor, Roland Watson, Sam Shuster, Tina Gaudoin, David Hands, Richard Johnson, Dr Nick Baylis, Dean Learner, Ian MacKinnon, Mark Gold, Amber Cowan, Genevieve Fox, David Charter, Tim Teeman, Patience Wheatcroft Business Editor, Caroline Merrell Banking Correspondent, Alistair Horne, Derwent May, Angela Jameson, Rose Barry, Kate Muir, JB, Ivan Hewett, Lewis Smith, Gabriel Rozenberg and Tosin Sulaiman, Robert Burrow, Tom Petherick, Russell Kempson, Peter Paphides, David Rowan, Armchair Warrior, Mary Gold, Tony Halpin Education Editor, Richard Cork, Oliver Kay, Norman Giller, Luke Coppen, Felipe Fernandez-Armesto, Stephen Anderton, Jerome Burne, Brian Jackman, Ed Potton, Sarah Vine, Antony Bye, Mark Atherton, Neil Harman, Lisa Armstrong, TW, Tom Baldwin, Chris Power, Julia Magnet, Fiona Neill, G. J. C. Ingram, Rob Yorke, Simon de Bruxelles, Philip Webster and Lewis Smith, Rob Wright, John Hopkins Golf Correspondent, Elaine Monaghan, Amanda Platell, Stuart Miles, AF, Gabriel Rozenberg, Ian Fells, Neil Harman Tennis Correspondent, David Powell Athletics Correspondent, Arlene Judith Klotzko, Raymond Keene, Ray Main, Adam Sage, Matthew Pryor, Richard Miles Investment Editor, Vermilion, Gordon Ramsay, Banish Blemish, Colin Clague, Xan Rice, Rick Jones, Edward Harris, Mike Barnard, Pat Scott Don Young, Russell Hotten, Chris Campling, Le Bar De Magis, Helen Nugent, Christopher Martin-Jenkins Chief Cricket Correspondent, Sudi Pigott, Alex Hawkes, Nick Hasell, S. E. Harris, Christina Aguilera, David Hands Rugby Correspondent, Victoria O'brien, Peter Krijgsman, Stelia Shamoon, Steve Jelbert, Nigel Kendall, Anne Ashworth, John Goodbody, Joanna Pitman, Tosin Sulaiman, Robert Crampton, Jane Shilling, Tony Canham, Julie Burchill, Ian Johns, Deborah King, Roderick Strange, Matthew Parris, VS, Virginia Blackburn, Jennai Cox, Peter De Lane, Amanda Craig, Frank Greaney, Chris Hedge, George Caulkin, Jonathan Rendall, Russell Jenkins, Peter Farrer, Chris McGrath, Ingrid Mansell, John Lister-Kaye, Iain Finlayson, John Angerson, Trans Fats, Caitlin Moran, Ben MacIntyre, Garth Marenghi, DC, Kitchen Greats, Andrew G Marshall, Carola Long, Alison Gibson, Jack Malvern Arts Reporter, Richard Miles, John Naish, Lea Paterson, Lewis Stuart, Martin Waller, Mark Henderson, Michael Horsnell, Chris Ayres, Laura Peek, Sarah Butler, Emma Hartley, Benedict Nightingale, Darian Leader, Angus Batey, Tim Wapshott, Jonathan Meades, Lucretia Stewart, Jill Crawshaw, Stephen Dalton, Felix Baumgartner, Fred Dellar, John Parker, Tom Chesshyre, James Christopher, Arwa Haider, Adam Sherwin, Abigail Rayner, Simon Crompton, Lucy Broadbent, Clive Hirschhorn, Alan Lee Racing Correspondent, Xan Rice and Joe Morgan, Mark Harrison, Cath Urquhart Travel Editor, Jenny Davey, Paul Henderson, Porini Camp, Nick Meo, Michael Streeter, Irma Kurtz, Gary Rathbone,
... Be Seen Ask Aggie Leather Man When designer Tomas Maier got weaving at Bottega Veneta, he turned around ...
2004 - Gale Group | TDA
Marta Choińska, Ivana Šestáková, Vojtěch Hrdlička, Jana Skopalová, Jan Langmaier, Vítězslav Maier, Tomáš Navrátil,
The review describes fentanyl and its analogs as new synthetic opioids and the possibilities of their identification and determination using electrochemical methods (e.g., voltammetry, potentiometry, electrochemiluminescence) and electrochemical methods combined with various separation methods. The review also covers the analysis of new synthetic opioids, their parent compounds, and corresponding metabolites in body fluids, such as urine, blood, serum, and plasma, necessary for a fast and accurate ...
Tópico(s): Advanced Chemical Sensor Technologies
2022 - Multidisciplinary Digital Publishing Institute | Biosensors
Jonathan James-Moore, Michael Prescott, Steve Pittard, Margaret James, Matthew Wall, Mo Shapiro, Don Taylor, C Thibaut, John Follain, Barbara Hall, Frank Parker, Daniela Paudice, J B, Christine McGourty, Francois Pienaar, Fred Redwood, Carole Dawson, Aady Knott, Jon Swain, John Perter, James Clark, Nicholas Rufford, John Peter, Pam Barrett, Jan Ladbrooke, Amanda Ursell, Emma Moore, Lorraine Harvey, Miranda Innes, Lance Jenkins, John Jay, J D, Sally Thomson, Frank Whitford, Ivo Tennant, Martin Butler, M Bibal, Sam Gilpin, Sally O'Reilly, Tanya, David Smith, Graham Henry, Richard Bond, caroline Donald, Melanie Phillips, Nick Pitt, Neil Wormald, E P, Andrew Sullivan, Dave Ferris, Clive Davis, Preston King, Mary Wilson, Sarah Keighley, Hywel Williams, Ella, Clive Woodward, William Brittain, Tony Allen-Mills, Martin James, Isabella Blow, John Gardner, Tom Walker, Anthony Sattin, Robert Winnett, Nick Gardber, Irwin Stelzer, Charles Nicholl, Tom English, Robert Hewison, Peter Wilson, Roger Anderson, Simon Fanshawe, Lawrence Dallaglio, David Dougill, York Membery, John Mortimer, John Evans, Philip Kingsley, Cathy Cooper, Sue Clayton, David Hewson, J Alexander, Tania Alexander, Cath Sylvester, Cary L Cooper, Margaret Coles, Hugh Canning, Alasdair Reid, Hugh Mcllvanney, Margarette Driscoll, Martin Davies, Jeremy Clarkson, Peter Watson, Nigel Williams, Dorothy Andrew, Christine Stopp, Louise Taylor, John Waples Deputy City Editor, Edward Porter, Max Anderson, Stewart Lee, Peter Kemp, K E Mawardy, Eben Black, Nick Newman's, Brian Rowe, Lynne Wallis, Graham, Tony Misiolek, Phil Craigie, Adam Nathan, James Bailey, Phil Greening, Nick Gardner, Robert Howlett, Phillip Oppenheim, Stuart Wavell, Stella Bingham, Josephine Smit, Alastair Hendy, Neil Back, Sir Richard Sykes, Clive Jacobs, Lisa Jardine, Simon Mills, Cosmo Landerson, James Clark Home Affairs Correspondent, Smita Talati, Paul Driver, Paul Bray, Malcolm Farrow, Gillian Taylforth, John Humphrys, Andrew Hagley, Maeve Sheehan, Nicholas Hellen, Peter Windsor, Richard Brooks, Ian Hawkey, David Thomas, Steve, Christopher Morgan, Rob Lane editor, Shelley Von Strunckel, Tim Rayment, Brian Jackman, Geoffrey Holmes, Antonella Lazzeri, Sue Beenstock, Mark Edwards, Duncan Lawson, Sarah Gracie, Susan Clark, Ken Livingstone, Mark Austin, David Lawrenson, Eben Black Chief Political Correspondent, Liz Reld, Matt Dawson, Rose, Danny O'Brien, T W, Jennifer Asiama, Alan Combes, Sue Reid, Raymond Keene, Senay Boztas, Zoe Brennan, Cosmo Landesman, Diana Wright, Kipper Williams, S N, David Orr, Chris Partridge, Stephen Jones, Richard Evans, Peta Bee, Melanie Philips, Arnaud Bani, Bill Turque, M J, Gary Buchanan, Rob Ryan, Dr John Greensmith, Claire Oldfield, David Walsh, Trevor Lewis, Jack Grimston, S P, Bryan Appleyard, Lois Rogers Medical Correspondent, Colin McDowell, Stephen Armstrong, F C, Ron Clarke, Christopher Goodwin, Josh Salzmann, Bethan Cole, Mark Prigg, Victoria O'brien, Roland White, Garth Alexander, Robert Henderson, Kim Fletcher, David Young, Maurice Chittenden, Alex Fortune, Kevin Pratt, Richard Brooks Arts Editor, Richard Rae, Mark Franchetti, Jonathan Powell, Ray Hutton, Jon Ungoed-Thomas, Andrew Oakes, Andrew Rogers, Michele Kirsch, Deborah Williams, Jonathan Leake, S J, John Crossland, Michael Sheridan, Christine Webb, Alison Steed, Godfrey Smith, Wendy Worviell, Jacqueline Champ, Camp Beaumont, Hilary Lowe, Trevor Rees-Jones, John Waples, Jeremy Hart, Hunter Davies, A A Gill, Anna Selby, Matthew Campbell, Brian Glanville, Anthony Croft, Tom Robbins, Stephen Pettitt, Jonathan Leake Science Editor, Karen MacGregor, Jeremy Langmead, R H, Eric McGraw, Andrew Lorenz, Sally Kinnes, Naomi Caine, Hazel Courteney, Nicholas Hellen Media Editor, David Wickers, Silvia Rodgers, Roger Dobson, Tom Rhodes, John Chambers, Len Tyler, John Aizlewood, Mrs J Hughes, Emma Penn, Mark Hodson, Graham Norwood, Joe Lovejoy, Jonathan Futrell, Mark Porter, Rupert Steiner, David Parstey, Dan Cairns, David Grylls, David Parsley, Allan Hall, Thomas Gilchrist, Brian Alexis, Claire Burston, David Smith Economics Editor, Ken Ellis, Mrs D Brooker, Simon Crerar, Anthony Howard, Helen Vandevelde, Martin Booth, Bob Dwyer, Walter Ellis, Joanna Simon, India Knight, Stephen Peters, Steve Grant, Simon Howard, Danny Danziger, Dan Pearson, Lisa Verrico, Dominic Rushe, Boris Schapiro, Karen Robinson,
... Asiama This page: black tube top, £120, by Tomas Maier,… Jones Boot Maker Celline Daring All Opposite page: ...
2000 - Gale Group | Sunday Times HA GDA
Vlastimil Křápek, Ai Leen Koh, Lukáš Břínek, Martin Hrtoň, Ondřej Tomanec, Radek Kalousek, Stefan A. Maier, Tomáš Šikola,
We present a study of the optical properties of gold crescent-shaped antennas by means of electron energy loss spectroscopy. These structures exhibit particularly large field enhancement near their sharp features, support two non-degenerate dipolar (i.e., optically active) localised surface plasmon resonances, and are widely tunable by a choice of their shape and dimensions. Depending on the volume and shape, we resolved up to four plasmon resonances in metallic structures under study in the energy ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2015 - Optica Publishing Group | Optics Express
Conor Cruise O'Brein, Jill Furmanovsky, Harry Kay, John Coleman, Barbara Hall, Will Ellsworth-Jones, Richard Ellis, John Jay City Editor, John Davison, Jon Swain, Anthony Clare, Tommy Long, Rob Hughes, John Peter, Duncan Fallowell, Mark Reason, Jeremy Laurance, Bemard Cafferty, Jonathan Miller, Eric Dymock, Peter Coe, Josephine Barber, Anna Chopra, Sarah Miller, Martin Parris, John Jay, Neville Hodgkinson Medical Correspondent, Graham Rose, Anthony Bambridge, Roy Porter, Norman Howell, Nicolette Jones, Maggie Hambling, Alistair Scott, Carolyn Hart, Robin Morgan, Sally Payne, Stanley Reynolds, Jean Viall, George Robertson, Anna Home, Marten Julian, Frederic Raphael, Brian Lavery, John Davision, Jo Revill, Professor Euan Uglow, Jason Tomas, Edward Welsh, Manfred Ruter, Miriam Margolyes, Gerald Priestland, Richard Eaton, Caroline St John-Brooks, Jon Craig, Geordie Greig, Patrick Stoddart, Judi Bevan Deputy City Editor, Mario Modiano, R Harris, Alex Sutherland, Robert Sandall, Iain Johnstone, Susan Marling, Adrian Morant, David Brierley, Anthony Sattin, Irwin Stelzer, Will Ellsworth-Jones Travel Editor, Patricia Stoughton, Peter Godwin, Ivan Fallon, Bernard Levin, Deryk Brown, Mick Brown, Paul de Monchaux, David Dougill, John Mortimer, Geordie Greig Arts Correspondent, Brian Redhead, Cliff Temple, David Shannon, Sebastian, Gianni Giansanti, Egon Ronay, Jane Bird Technology Editor, Simon Gray, Julian Critchley, Professor Robert Medley, Susan Crosland, David Goldsmith, Norman Harris, David Connett, Jeanette Winterson, Robin Knox-Johnson, Richard Cobb, Mr and Mrs J C Beck, Patrick George, Geoff Whitten, Anne Moffat, Michael Jones, Paul Hoffman, Anthony Quinton, Richard Palmer Environment Correspondent, George Perry, John Cassidy, Sue Mott, Marion Devine, Kenneth Baker's, Philip Glazebrook, Paul Bailey, Christine Toomey, A J Ayer, Brian Moynahan, Neil Maclean, Hughie Green, Roger Eglin, Paul Donovan, Janette Marshall, Enoch Powell, Ann Hay, Jim Brandenburg, Nigella Lawson, Jeff Randall, Paul Ableman, Malcolm Smith, Paul Driver, James Adams, John Ardagh, Leonardo da Vinci, John Annand, Austin MacCurtain, Elizabeth Grice, David Lawrenson, Wilfred Peters, Frank Smith, John Hopkins, Askold Krushelnycky, Geoffrey Warren, Martin Jacques, Judi Bevan, Jill Neville, Brian Walden, Peter May, Peter Wilsher, Stephen Wood, Gareth David, Mrs M. G. Pattison, Brian Reading, Simon Freeman, Stephen Pile, John Grigg, Malcolm Winton, Catherine Hall, James Wilson, Marie Colvin, Greg Hadfield, Diana Wright, Richard Cook, Craig Brown, Peter Fuller, Diana Wright Personal Financeeditor, Michael Pollard, Stephen Jones, Councillor Simon Fawthrop, Kenneth Clarke, Robin Day, Melvyn Bragg, Andrew Grice, Michael Harris Chairman, Kate Cruise O'Brien, Lynne McTaggart, R Wheelhouse, Miranda Seymour, Ian Birrell, Helen Thorpe, Patrick Rowley, Arthur Taylor, Gabriel Ronay, Stephen Davis, Dilys Powell, Bryan Appleyard, Wendy Sly, Russell Miller, Graham Brough, Brough Scott, Alison Beckett, Michael Podro, Richard Woods, Clive Everton, Caroline McGhie, Norman Stone, Peter Johnson, Louise Branson, David Profumo, Marion Hume, Deborah Hutton, Maurice Chittenden, Max Prangnell, Barrie Penrose, Ian Dunning, Iola Smith, Joy Melville, Maxim Levenson, David Hughes Political Correspondent, Brian MacArthur, Professor Howard Hodgkin, Michael Jones Political Editor, Philip Roth, Susan Raven, Steve Tongue, Daniel Klinger, Simon Callow, Conrad Russell, Godfrey Smith, Sue Thomas, Mark Whitaker, Charles Oulton, Greg Hadfield Education Correspondent, Brian Glanville, Angus Roxburgh, John Carey, John Julius Norwich, Edward Pearce, Malachy McGrady, Colin Dunne, Simon Jenkins, Jon Craig Home Affairs Correspondent, Deirdre Fernand, George Steiner, J Rees, Peter Wirz, David Wickers, Rev C Channer, Earl Grey, Anne Wilson, David Yelland, Ian Williams, Professor Paul Huxley, Victor Bryant, Valerie Grove, Hugh Pearman, Marina Vaizey, Ralph Shandilya, Rosemary Collins, Angela Long, Tony Hetherington, Jim Muir, Joanna Simon, P S Falla, James Adams Defence Correspondent, Peter Casely-Hayford, Boris Schapiro, (Mrs) M W Philpott,
... Rob Hughes about the risk game Merle topples Maier Robin Marlar on Peter May Essex beat the ...
1988 - Gale Group | Sunday Times HA GDA
This article aims to use three quantitatively stated hypotheses to determine the reasons for the rise of microbreweries in the Czech Republic, whose numbers have been growing constantly since 1991. The explanations defined by the hypotheses are concentration growth, and thus the fall in the number of units of production in the industrial brewery segment, the quantitative impact of beer consumption, and finally again a quantitatively-defined demographic aspect. The results are summarised and elaborated ...
Tópico(s): Organic Food and Agriculture
2013 - Czech University of Life Sciences Prague | Agris on-line Papers in Economics and Informatics
Maier Becker, Tomas Karpati, Liora Valinsky, Anthony Heymann,
This retrospective review of an Israeli computerized medical data base assessed visits to emergency departments in the 48 h following the commencement of the Jewish Yom Kippur fast in the years 1999–2009, and showed that fasting does not seem to be associated with an increased rate of visits.
Tópico(s): Diabetes Management and Education
2012 - Elsevier BV | Diabetes Research and Clinical Practice
Ondřej Hylse, Lukáš Maier, Roman Kučera, Tomáš Perečko, Aneta Svobodová, Lukáš Kubala, Kamil Paruch, Jakub Švenda,
Abstract A 24‐step synthesis of (±)‐forskolin is presented, which delivered hundred milligram quantities of this complex diterpene in one pass. Transformations key to our approach include: a) a strategic allylic transposition, b) stepwise assembly of a sterically encumbered isoxazole ring, and c) citric acid‐modified Upjohn dihydroxylation of a resilient tetrasubstituted olefin. The developed route has exciting potential for the preparation of new forskolin analogues inaccessible by semisynthesis.
Tópico(s): Carbohydrate Chemistry and Synthesis
2017 - Wiley | Angewandte Chemie International Edition
This article aims to determine the reasons for the number of microbreweries increasing in the Czech Republic.The analysis compares various (micro)brewing industry indicators in selected traditional beerdrinking countries.The research questions are focused on relations among number of microbreweries and demographic aspects, market concentration aspects and some other beer market indicators.Furthermore, there were made simulation -for which conditions will be in the Czech Republic 400, 500 and 1 000 ...
Tópico(s): Organic Food and Agriculture
2016 - Czech University of Life Sciences Prague | Agris on-line Papers in Economics and Informatics
Morten A. Høydal, Tomas Stølen, Sarah Kettlewell, Lars S. Maier, Joan Heller Brown, Tomas Sowa, Daniele Catalucci, Gianluigi Condorelli, Ole Johan Kemi, Godfrey L. Smith, Ulrik Wisløff,
Several conditions of heart disease, including heart failure and diabetic cardiomyopathy, are associated with upregulation of cytosolic Ca(2+)/calmodulin-dependent protein kinase II (CaMKIIδC) activity. In the heart, CaMKIIδC isoform targets several proteins involved in intracellular Ca(2+) homeostasis. We hypothesized that high-intensity endurance training activates mechanisms that enable a rescue of dysfunctional cardiomyocyte Ca(2+) handling and thereby ameliorate cardiac dysfunction despite continuous ...
Tópico(s): Cardiovascular Function and Risk Factors
2016 - American Physiological Society | Journal of Applied Physiology
Jean‐Luc Guermond, Matthias Maier, Bojan Popov, Ignacio Tomaš,
We present a fully discrete approximation technique for the compressible Navier-Stokes equations that is second-order accurate in time and space, semi-implicit, and guaranteed to be invariant domain preserving. The restriction on the time step is the standard hyperbolic CFL condition, ie $\tau \lesssim \mathcal{O}(h)/V$ where $V$ is some reference velocity scale and $h$ the typical meshsize.
Tópico(s): Numerical methods for differential equations
2020 - Elsevier BV | Computer Methods in Applied Mechanics and Engineering
Lukáš Maier, Tomáš Šolomek, Matej Pipíška, Zdeněk Křı́ž, Marek Nečas, Radek Marek,
Abstract New derivatives of protoberberine alkaloids were prepared by nucleophilic addition of some azoles (differing in bulkiness) to the iminium functionality of the quaternary protoberberine alkaloids. Compounds were structurally characterized mainly by 1H and 13C NMR spectroscopy, and the structure of 8-carbazol-1-yl-7,8-dihydroberberine was determined using single-crystal X-ray diffraction. Additionally, conformational behaviors of five derivatives varying in bulkiness of the azole moiety have ...
Tópico(s): Synthesis and Biological Activity
2010 - Elsevier BV | Tetrahedron
David Friedecký, Jana Tomková, Vítězslav Maier, Anna Janošťáková, Martin Procházka, Tomáš Adam,
Purine and pyrimidine nucleotides influence many metabolic pathways and their analogs have been widely used in medicine. A capillary electrophoretic method was developed for measuring intracellular nucleotides. The final BGE consisted of 40 mM citric acid with addition of 0.8 mM CTAB titrated by gamma-aminobutyric acid to pH 4.4. The electrophoretic separations were carried out in an uncoated silica capillary (id/od - 75/375 microm; effective/total length - 90/97 cm). The method allows a complete separation ...
Tópico(s): Cytomegalovirus and herpesvirus research
2007 - Wiley | Electrophoresis
Michal Malý, Zdeňka Žáková Kroupová, Dana Žídková, Jarmila Peterová, L. Šobrová, Lukáš Čechura, Ludmila Pánková, Jiří Mach, Zuzana Smeets Kristkova, Tomáš Maier, Jan HUČKO,
The main aim of the paper was a partial analysis of the production potential for pig fattening in the Czech Republic. This aim was achieved by econometric modelling of the production function, which was specified as a Cobb-Douglas function, with the level of average daily increase as the dependent variable, and feed compounds, mortality and weight of new stock as independent variables. The model was specified as a fixed effect model, and the parameters of the function were estimated by the method ...
Tópico(s): Genetic and phenotypic traits in livestock
2011 - Czech Academy of Agricultural Sciences | Agricultural Economics (Zemědělská ekonomika)
Jean‐Luc Guermond, Martin Kronbichler, Matthias Maier, Bojan Popov, Ignacio Tomaš,
This paper describes in detail the implementation of a finite element technique for solving the compressible Navier–Stokes equations that is provably robust and demonstrates excellent performance on modern computer hardware. The method is second-order accurate in time and space. Robustness here means that the method is proved to be invariant domain preserving under the hyperbolic CFL time step restriction, and the method delivers results that are reproducible. The proposed technique is shown to ...
Tópico(s): Numerical methods for differential equations
2021 - Elsevier BV | Computer Methods in Applied Mechanics and Engineering
G. Agakichiev, C. Agodi, H. Álvarez-Pol, E. Atkin, E. Badura, A. Balanda, Angelo Bassi, R. Bassini, G. Bellia, D. Belver, A. Belyaev, M. Benovič, D. Bertini, J. Bielcik, M. Böhmer, C. Boiano, H. Bokemeyer, A. Bartolotti, J. L. Boyard, S. Brambilla, P. Braun-Munzinger, P. Cabanelas, E. Castro, V. F. Chepurnov, S. Chernenko, T. Christ, R. Coniglione, L. Coséntino, M. Dahlinger, H. Daues, M. Destefanis, J. Dı́az, F. Dohrmann, R. Dressler, I. Durán, A. Dybczak, T. Eberl, W. Enghardt, L. Fabbietti, O. Fateev, C. Fernández, P. Finocchiaro, J. Friese, I. Fröhlich, B. Fuentes, T. Galatyuk, C. Garabatos, J. A. Garzón, B. Génolini, R. Gernhäuser, C. Gilardi, H. Albert Gilg, M. Golubeva, D. González-Díaz, E. Grosse, F. Guber, J. Hehner, K. Heidel, T. Heinz, T. Hennino, S. Hlaváč, J. Hoffmann, R. Holzmann, J. Homolka, J. Hutsch, A. P. Ierusalimov, I. Iori, A. Ivashkin, Marian Jaskuła, J.C. Jourdain, M. Jurkovic, B. Kämpfer, M. Kajetanowicz, K. Kanaki, T. Karavicheva, A. Kastenmüller, L. Kidoń, P. Kienle, D. Kirschner, I. Köenig, Wolfgang Köenig, H.J. Körner, B. W. Kolb, U. Köpf, K. Korcyl, R. Kotte, A. Kozuch, F. Krizek, R. Krücken, W. Kühn, A. Kugler, R. Kulessa, A. Kurepin, T. Kurtukian‐Nieto, Stephan Lang, J. S. Lange, K. Lapidus, J. Lehnert, U. Leinberger, C. Lichtblau, E. Lins, C. Lippmann, M. Lorenz, D. Magestro, L. Maier, P. Maier‐Komor, C. Maiolino, A. Malarz, Tomáš Marek, J. Markert, V. Metag, B. Michalska, J. Michel, E. Migneco, D. Mishra, E. Morinière, J. Mousa, M. Münch, C. Müntz, L. Naumann, A. Nekhaev, W. Niebur, Jiří Novotný, R. Novotny, W. Ott, J. Otwinowski, Y. Pachmayer, M. Pałka, Y. Parpottas, V. Pechenov, O. Pechenova, T. Pérez Cavalcanti, M. Petri, P. Piattelli, J. Pietraszko, R. Pleskač, M. Płoskoń, V. Pospíšil, J. Pouthas, W. Prokopowicz, W. W. Przygoda, B. Ramstein, A. Reshetin, J. Ritman, G. Roche, Gonzalo Rodríguez Prieto, Karin Rosenkranz, P. Rosier, M. Roy-Stéphan, A. Rustamov, Juan Sabín, A. Sadovsky, B. Sailer, P. Salabura, C. Salz, M.L. Sánchez, P. Sapienza, D. Schäfer, R. Schicker, A. M. Schmah, H. Schön, Wolfgang Schön, C. Schroeder, S. Schroeder, E. Schwab, P. Senger, K. Shileev, R.S. Simon, Maximilian W. A. Skoda, V. Smolyankin, L. Smykov, M. Sobiella, Yu. G. Sobolev, S. Spataro, B. Spruck, H. Stelzer, H. Ströbele, J. Stroth, C. Sturm, M. Sudoł, M. Suk, M. Szczybura, A. Taranenko, A. Tarantola, K. Teilab, V. Tiflov, A. Tikhonov, P. Tlustý, A. Toia, M. Traxler, R. Trȩbacz, A. Yu. Troyan, H. Tsertos, I. Turzo, A. Ulrich, Dmitri Vassiliev, A. Vázquez, Yu. N. Volkov, V. Wagner, C. Wallner, W. Waluś, Y. Wang, M. Weber, J. Wieser, S. Winkler, M. Wiśniowski, Tomasz Wójcik, J. Wüstenfeld, S. Yurevich, Y. Zanevsky, K. Zeitelhack, A. Zentek, Pei Zhou, D. Žovinec, P. Zumbruch,
HADES is a versatile magnetic spectrometer aimed at studying dielectron production in pion, proton and heavy-ion induced collisions. Its main features include a ring imaging gas Cherenkov detector for electron-hadron discrimination, a tracking system consisting of a set of 6 superconducting coils producing a toroidal field and drift chambers and a multiplicity and electron trigger array for additional electron-hadron discrimination and event characterization. A two-stage trigger system enhances ...
Tópico(s): Quantum Chromodynamics and Particle Interactions
2009 - Springer Science+Business Media | The European Physical Journal A
Nicolas M. Van Mieghem, G. Michael Deeb, Lars Søndergaard, Eberhard Grube, Stephan Windecker, Hemal Gada, Mubashir Mumtaz, Peter Skov Olsen, John Heiser, William Merhi, Neal S. Kleiman, Stanley Chetcuti, Thomas G. Gleason, Joon Sup Lee, Wen Cheng, Raj Makkar, Juan A. Crestanello, Barry George, Isaac George, Susheel Kodali, Steven J. Yakubov, Patrick W. Serruys, Rüdiger Lange, Nicolò Piazza, Mathew Williams, Jae K. Oh, David Adams, Shuzhen Li, Michael J. Reardon, Christopher B. Gitter, Karen Meyer, Dana Roberts, Richard Bae, Paul Sorajja, Benjamin Sun, Judah Askew, Frazier Eales, Thomas Flavin, Mario Goessl, Vibhu R. Kshettry, M. Mooney, Wesley R. Pedersen, Anil Poulose, Pezhman Roohani, Robert Saeid Farivar, Richard Shronts, R Tarrel, Mark Young, Eddy Butkus, Kristin Pendleton, Robert D. Fry, Carl Heine, Kristin La Roe, Tin Trung Tran, Laura Weig, Himanshu Agarwal, Thomas Langdon, Ruby Satpathy, John Batter, Karen Bremer, Unajyothi Indukuri, Marijke Baas, Corry Oomes-Sistermans, Manola Smits, Carien Coenen, Inge Driesen, Lia Lauryssen, Margreet Poorter, Jeroen Schaap, Mohamed Bentala, Peter den Heijer, Jan Pieter, Michel Remmers, Marie Story, Paul M.M. van Erven, H Verbiest, Jeroen Vos, Michelle Bennett, Wendy Dunaj, Deborah Seaton, Deborah A. Waller, Bijoy K. Khandheria, Tanvir Bajwa, Daniel O’Hair, Arshad Ahmed, Suhail Allaqaband, Ayman Gheith, Elizabeth Marriott, Ajaz Qhavi, Varun Kumar Saxena, Akram Shhadeh, Paul Werner, Christine Yeomans, Lynn Bessette, Jessica Byrne, Heather Kieckhefer, Marleny Munoz, Elizabeth Russo, Jason Klein, Michael M. Morgan, Timothy Byrne, Michael Caskey, Orazio Amabile, Kevin P. Brady, Steven Chung, Kelly Dacanay, Hao Fang, Douglas Franz, Claire Kelly, Akil Loli, Jeremy Payne, Ashish Pershad, Norman C. Wang, Jessi Lott, C. Angele Pool-Owens, Charlotte M. Porter, Jeffrey A. Hennan, H. Edward Garrett, Basil Paulus, J. Cymerman Craig, Lucas Elijovich, Joseph Samaha, Bradley A. Wolf, Lance Wright, Gilbert J. Zoghbi, Leslie Willcott, Brad Roberts, Robert F. Hebeler, Robert Stoler, Dion Graybeal, Paul Grayburn, Carl Ferdinand Howard Henry, Osman Mir, Ravi C. Vallabhan, Matthew Fanous, Jenifer Kaufman, James D. Chang, Warren J. Manning, Marilyn F. Riley, Kamal R. Khabbaz, Roger J. Laham, Jeffrey J. Popma, David F. Burke, Louis R. Caplan, Shing Fung Chui, Kim Guibone, S. Sendil Kumar, Vasileios‐Arsenios Lioutas, David Liu, Senthil Nathan, Duane S. Pinto, D. Eric Searls, Susan G. Fisher, Lindsay Guirgues, Sue Henderson, Laura Ashley Loving, Nicole McWalters, Kelly Patterson, Jesse Burkart, Bryan Carcedo, Russell Stacey, Mark Bladergroen, D. Scott Lim, Supakunya Edmonson, Stacey Epps, Marc Katz, Ken Ng, Amandeep Sangha, Jennifer Aucoin, Monique Roberts, Jaime Aubin, Callie Hotard, Michelle Tassin, Peter Fail, Edgar Feinberg, Donald Netherland, Richard Abben, Mohamad Allam, Michael Bates, Richard Dearman, Donald Gervais, Edward Haight, Michael Metes, Jeanette Naquin, Victor Tedesco, Lisa Thibodeaux, Karen Thompson, Sally Aberle, Dana Amaro, William Grey, Geoffrey Rose, M. Schérer, Michael Rinaldi, Eric Skipper, Charles R. Bridges, William Downey, Phaniraj Iyengar, Jerry L. Martin, Liam Ryan, Robert Stiegel, John S. Story, Khaled Alsabaawi, Mitch Gheorghiu, Chetana Singh, Jason Yashar, Robert J. Siegel, Wen Cheng, Raj Makkar, Karen Altman, Hasan Jilaihawi, Saibal Kar, Stephanie Khouw, Cyrus C. M. Mody, Danny Ramzy, Tracey Salseth, Jasminka Stegic, Alfredo Trento, Rosa Lazarte, Jeanie Sohn, Rebecca T. Hahn, Omar Khalique, Isaac George, Susheel Kodali, Mathew Williams, Marco Gonzalez Castellon, José Contreras, Tomoko Kitago, Benjamin Kummer, Tim Lekic, Eliza C. Miller, Yoshifumi Naka, Tamim Nazif, Abid Qureshi, Sara Rostanski, Craig R. Smith, Joshua Z. Willey, Shadi Yaghi, Leana Abreu, Emerson Clement, Sajjad Sabir, Janah Aji, Frank W. Bowen, Georges Kaddissi, Thomas Mirsen, Muhammad Muntazar, Jeffrey Ogbara, Michael Rosenbloom, W Schell, Ryna Then, Heidi Carl, Hong Huang, Ghassan Kreydi, Heather Wolak, Gregory Sandidge, Omar E. Ali, Zewditu E. Asfaw, Scott P. Henry, Ali Kafi, Theodore Schreiber, Lourdes Andaya, Frank A. Baciewicz, Joseph Bassett, Nishit Choksi, Safwan Kassas, Ahmad Munir, Franziska Kothmeier, Annemarie Stroh, Gertrud Goppel, I Hettich, Sabine Bleiziffer, Christian Hengstenberg, A Opitz, Hendrik Ruge, Catalin Constantin Badiu, Susanne C. Brenner, Yacine Ehlmidi, Ulf Herold, Albert Markus Kasel, Robert Josef Kreuzpointner, Rüdiger Lange, Domenico Mazzitelli, Holger Poppert, Christian Seifert, Dóra Vincze, Bernhard Voß, Krista Camuglia, Dahlia Cowhig, Stephanie P. Newbold, Cynthia Pierce, Samantha Wootton, Sreekanth Vemulapalli, Eric J. Velazquez, James Harrison, G. Chad Hughes, Yasmin Ali, Ali Babi,
In patients with severe aortic valve stenosis at intermediate surgical risk, transcatheter aortic valve replacement (TAVR) with a self-expanding supra-annular valve was noninferior to surgery for all-cause mortality or disabling stroke at 2 years. Comparisons of longer-term clinical and hemodynamic outcomes in these patients are limited.To report prespecified secondary 5-year outcomes from the Symptomatic Aortic Stenosis in Intermediate Risk Subjects Who Need Aortic Valve Replacement (SURTAVI) randomized ...
American Medical Association
Daniel Arndt, Wolfgang Bangerth, Bruno Blais, Thomas C. Clevenger, Marc Fehling, Alexander Grayver, Timo Heister, Luca Heltai, Martin Kronbichler, Matthias Maier, Peter Münch, Jean‐Paul Pelteret, Reza Rastak, Ignacio Tomaš, Bruno Turcksin, Zhuoran Wang, David Wells,
Abstract This paper provides an overview of the new features of the finite element library deal.II, version 9.2.
Tópico(s): Electromagnetic Scattering and Analysis
2020 - De Gruyter | Journal of Numerical Mathematics
Produção Nacional
Peter Kepič, Filip Ligmajer, Martin Hrtoň, Haoran Ren, Leonardo de S. Menezes, Stefan A. Maier, Tomáš Šikola,
Metasurfaces are ultrathin nanostructured surfaces that can allow arbitrary manipulation of light. Implementing dynamic tunability into their design could allow the optical functions of metasurfaces to be rapidly modified at will. The most pronounced and robust tunability of optical properties is provided by phase-change materials such as vanadium dioxide (VO2) and germanium antimony telluride (GST), but their implementations have been limited only to near-infrared wavelengths. Here, we demonstrate ...
Tópico(s): Polydiacetylene-based materials and applications
2021 - American Chemical Society | ACS Photonics
Juan Jorge Michel Fariña, Alejandra Tomas Maier,
¿Puede el cine verdaderamente ayudarnos a conocernos más y a convivir mejor con nuestro deseo? Esta pregunta se presenta tanto ante aquellos filmes en los que el director se propone de manera explícita presentar el debate moral contemporáneo, como en aquellos otros en los que son los espectadores y analistas quienes recortan en la obra de arte la ocasión para la reflexión ética. En ambos casos el resultado es una extraordinaria experiencia de pensamiento y acción. Pero persiste la pregunta: ¿Cuáles ...
Tópico(s): Philosophical and Cultural Analysis
2016 - | Informática na educação teoria & prática
Tomáš Pluháček, Martin Švidrnoch, Vítězslav Maier, Vladimı́r Havlı́ček, Karel Lemr,
Tópico(s): Isotope Analysis in Ecology
2018 - Elsevier BV | Analytica Chimica Acta
Tomáš Pluháček, Michael Ručka, Vítězslav Maier,
Tópico(s): Pesticide Residue Analysis and Safety
2019 - Elsevier BV | Analytica Chimica Acta
Článek si klade za cíl ekonomicky zhodnotit stavbu minipivovaru v již zaběhnuté a fungující restauraci.Pivovar má očekávanou roční produkci
Tópico(s): Wine Industry and Tourism
2011 - Research Institute of Brewing and Malting | Kvasny Prumysl
Tomáš Pika, Ute Hegenbart, Pavla Flodrová, Bettina Maier, Christoph Kimmich, Stefan Schönland,
Tópico(s): Chronic Myeloid Leukemia Treatments
2017 - Elsevier BV | Blood
Dieter B. Wildenauer, Sibylle G. Schwab, Margot Albus, Joachim Hallmayer, Bernard Lerer, Wolfgang Maier, Douglas Blackwood, Walter Muir, David St Clair, Stewart W. Morris, Hans W. Moises, Yang Liu, Helgi Kristbjarnarson, Tómas Helgason, Claudia Wiese, David Collier, Peter Holmans, Jo Daniels, Mark I. Rees, Philip Asherson, Queta Roberts, Alastair G. Cardno, María J. Arranz, Homero Vallada, David Ball, Hiroshi Kunugi, Robin M. Murray, John Powell, S. Nanko, Pak C. Sham, Michael Gill, Peter McGuffin, Michael J. Owen, Ann E. Pulver, Stylianos E. Antonarakis, Robert Babb, J L Blouin, Nicola DeMarchi, Beth A. Dombroski, David E. Housman, Maria Karayiorgou, Jürg Ott, Laura Kasch, Haig H. Kazazian, Virginia K. Lasseter, Erika Loetscher, H. Luebbert, Gerald Nestadt, Carl C.T. Ton, Paula Wolyniec, Claudine Laurent, Michel de Chaldée, Florence Thibaut, Maurice Jay, Danièle Samolyk, Michel Petit, Dominique Campion, Jacques Mallet, Richard E. Straub, Charles J. MacLean, Stephen M. Easter, F. Anthony O’Neill, Dermot Walsh, Kenneth S. Kendler, Pablo V. Gejman, Qiuhe Cao, Elliot S. Gershon, Judith A. Badner, Ethiopia Beshah, Jing Zhang, Brien P. Riley, Swarnageetha Rajagopalan, Mpala Mogudi-Carter, Trefor Jenkins, Robert Williamson, Lynn E. DeLisi, Chad Garner, Mary Margaret Kelly, Carrie LeDuc, Lon R. Cardon, Jay B. Lichter, Tim Harris, J. Loftus, Gail Shields, Margarite Comasi, Antonio Vita, Angela Smith, J.C. Dann, Geoff Joslyn, Hugh Gurling, Gursharan Kalsi, Jon Brynjolfsson, David Curtis, Thordur Sigmundsson, Robert J. Butler, Tim Read, Patrice Murphy, Andrew Chih-Hui Chen, Hannes Pétursson, Bill Byerley, Mark Hoff, John Holik, Hilary Coon, Douglas F. Levinson, Derek J. Nancarrow, Raymond R. Crowe, Nancy C. Andreasen, Jeremy M. Silverman, Richard C. Mohs, Larry J. Siever, Jean Endicott, Lawrence Sharpe, Marilyn K. Walters, David P. Lennon, Nicholas K. Hayward, Lodewijk A. Sandkuijl, Bryan Mowry, H.N. Aschauer, K. Meszaros, E. Lenzinger, Karoline Fuchs, Yang Liu, A. Heiden, Hans W. Moises, Leonid Kruglyak, Mark Daly, Tara C. Matise,
In response to reported schizophrenia linkage findings on chromosomes 3, 6 and 8, fourteen research groups genotyped 14 microsatellite markers in an unbiased, collaborative (New) sample of 403–567 informative pedigrees per marker, and in the Original sample which produced each finding (the Johns Hopkins University sample of 46–52 informative pedigrees for chromosomes 3 and 8, and the Medical College of Virginia sample of 156–191 informative pedigrees for chromosome 6). Primary planned analyses (New ...
Tópico(s): Autism Spectrum Disorder Research
1996 - Wiley | American Journal of Medical Genetics
Adéla Čmoková, Miroslav Kolařík, Radim Dobiáš, Lois L. Hoyer, Helena Janouškovcová, Rui Kano, Ivana Kuklová, Pavlína Lysková, Lenka Machová, Thomas Maier, Naďa Mallátová, Matěj Man, Karel Mencl, Pietro Nenoff, Andrea Peano, Hana Prausová, Dirk Stubbe, Silke Uhrlaß, Tomáš Větrovský, Cornelia Wiegand, Vít Hubka,
Species of the Trichophyton benhamiae complex are predominantly zoophilic pathogens with a worldwide distribution. These pathogens have recently become important due to their epidemic spread in pets and pet owners. Considerable genetic and phenotypic variability has been revealed in these emerging pathogens, but the species limits and host spectra have not been clearly elucidated. In this study, we used an approach combining phylogenetic analysis based on four loci, population-genetic data, phenotypic ...
Tópico(s): Yeasts and Rust Fungi Studies
2020 - Springer Science+Business Media | Fungal Diversity
Václav Nêmec, Prashant Khirsariya, Pavlína Janovská, Paula Moyano, Lukáš Maier, Petra Procházková, Pavlína Kebková, Tomáš Gybeľ, Benedict‐Tilman Berger, A. Chaikuad, Maria Reinecke, Bernhard Küster, Stefan Knapp, Vı́tězslav Bryja, Kamil Paruch,
Casein kinases 1 (CK1) are key signaling molecules that have emerged recently as attractive therapeutic targets in particular for the treatment of hematological malignancies. Herein, we report the identification of a new class of potent and highly selective inhibitors of CK1α, δ and ϵ. Based on their optimal in vitro and in vivo profiles and their exclusive selectivity, MU1250, MU1500 and MU1742 were selected as quality chemical probes for those CK1 isoforms. At proper concentrations, MU1250 and ...
Tópico(s): Wnt/β-catenin signaling in development and cancer
2023 - Wiley | Angewandte Chemie International Edition
Ondřej Hylse, Lukáš Maier, Roman Kučera, Tomáš Perečko, Aneta Svobodová, Lukáš Kubala, Kamil Paruch, Jakub Švenda,
Abstract A 24‐step synthesis of (±)‐forskolin is presented, which delivered hundred milligram quantities of this complex diterpene in one pass. Transformations key to our approach include: a) a strategic allylic transposition, b) stepwise assembly of a sterically encumbered isoxazole ring, and c) citric acid‐modified Upjohn dihydroxylation of a resilient tetrasubstituted olefin. The developed route has exciting potential for the preparation of new forskolin analogues inaccessible by semisynthesis.
Tópico(s): Alkaloids: synthesis and pharmacology
2017 - Wiley | Angewandte Chemie