We present an exact and efficient branch-and-bound algorithm for finding a maximum clique in an arbitrary graph. The algorithm is not specialized for any particular kind of graph. It employs approximate coloring and appropriate sorting of vertices to get an upper bound on the size of a maximum clique. We demonstrate by computational experiments on random graphs with up to 15,000 vertices and on DIMACS benchmark graphs that our algorithm remarkably outperforms other existing algorithms in general. ...
Tópico(s): Algorithms and Data Compression
2003 - Springer Science+Business Media | Lecture notes in computer science
Tomokazu Seki, Kei Hamazaki, Takashi Natori, Hidekuni Inadera,
Internet addiction (IA) has various adverse effects. We sought to elucidate the relationship between IA and depression among university students and to identify factors associated with IA.Anonymous, self-administered questionnaires were distributed to 5,261 students and comprised basic characteristics, lifestyle habits, anxieties, the Internet Addiction Test (IAT), and the Center for Epidemiological Self-Depression Scale.Responses were obtained from 4,490 students (response rate: 85.3%). After excluding ...
Tópico(s): Digital Marketing and Social Media
2019 - Elsevier BV | Journal of Affective Disorders
Hideo Hidaka, H. Yoshino, Hideki Enokida, Takeshi Yamasaki, Toshihiko Itesako, Tomokazu Yonezawa, Naohiko Seki, Masayuki Nakagawa,
... Hirohumi Yoshino, Hideki Enokida, Takeshi Yamasaki, Toshihiko Itesako, Tomokazu Yonezawa, Naohiko Seki, and Masayuki Nakagawa Hideo HidakaHideo Hidaka Kagoshima, Japan ... Itesako Kagoshima, Japan More articles by this author Tomokazu Yonezawa Kagoshima, Japan More articles by this author Naohiko Seki Chiba, Japan More articles by this author Masayuki ...
Tópico(s): Renal and related cancers
2013 - Lippincott Williams & Wilkins | The Journal of Urology
Noriyasu Tezuka, Tomokazu Umeyama, Shu Seki, Yoshihiro Matano, Masayuki Nishi, Kazuyuki Hirao, Hiroshi Imahori,
The cluster formation, electrophoretically deposited film structures, microwave conductivity, and photoelectrochemical properties of the composites consisting of single-walled carbon nanotube (SWNT) with C60, C70, or C84 have been systematically compared for the first time. In an ortho-dichlorobenzene (ODCB)−acetonitrile mixture, the higher fullerenes (i.e., C70 and C84) were found to form single composite clusters exclusively with highly soluble SWNT bearing bulky swallow-tailed substituents (f-SWNT). ...
Tópico(s): Porphyrin and Phthalocyanine Chemistry
2010 - American Chemical Society | The Journal of Physical Chemistry C
Masanori Kobayashi, Tomokazu Yoshinaga, Takahiro Seki, Chiaki Wakasa-Morimoto, Kevin Brown, Robert G. Ferris, Scott A. Foster, Richard Hazen, Shigeru Miki, Akemi Suyama-Kagitani, Shinobu Kawauchi-Miki, Teruhiko Taishi, Takashi Kawasuji, Brian A. Johns, Mark Underwood, Edward P. Garvey, Akihiko Sato, Tamio Fujiwara,
S/GSK1349572 is a next-generation HIV integrase (IN) inhibitor designed to deliver potent antiviral activity with a low-milligram once-daily dose requiring no pharmacokinetic (PK) booster. In addition, S/GSK1349572 demonstrates activity against clinically relevant IN mutant viruses and has potential for a high genetic barrier to resistance. S/GSK1349572 is a two-metal-binding HIV integrase strand transfer inhibitor whose mechanism of action was established through in vitro integrase enzyme assays, ...
Tópico(s): Biochemical and Molecular Research
2010 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Yuichi Morikawa, Shusaku Nagano, Kentaro Watanabe, Kaori Kamata, Tomokazu Iyoda, Takahiro Seki,
Optical 3D alignment of nanocylinders has been successfully attained for thin films of a block copolymer (see figure) comprising azobenzene-containing liquid-crystalline polymers and poly(ethylene oxide) via photoinduced massive migration. The out-of-plane and in-plane alignments are achieved by controlling the film thickness and selection of linear polarization direction upon illumination, respectively.
Tópico(s): Advanced Materials and Mechanics
2006 - | Advanced Materials
Takashi Kawasuji, Brian A. Johns, Hiroshi Yoshida, Teruhiko Taishi, Yoshiyuki Taoda, Hitoshi Murai, Ryuichi Kiyama, Masahiro Fuji, Tomokazu Yoshinaga, Takahiro Seki, Masanori Kobayashi, Akihiko Sato, Tamio Fujiwara,
Our group has focused on expanding the scope of a two-metal binding pharmacophore concept to explore HIV-1 integrase inhibitors through medicinal chemistry efforts to design novel scaffolds which allow for improvement of pharmacokinetic (PK) and resistance profiles. A novel chelating scaffold was rationally designed to effectively coordinate two magnesium cofactors and to extend an aromatic group into an optimal hydrophobic pharmacophore space. The new chemotype, consisting of a carbamoyl pyridone ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2012 - American Chemical Society | Journal of Medicinal Chemistry
Mina Han, Sung June Cho, Yasuo Norikane, Masaki Shimizu, Akinori Kimura, Tomokazu Tamagawa, Takahiro Seki,
A new azobenzene-based chromophore was synthesized to create one-dimensional (1D) nanofibers with aggregation-induced emission enhancement characteristics. The enhanced red fluorescence of the fibrous structures can be switched off via mechanical pressure, friction, or heat by pressing, rubbing, or annealing.
Tópico(s): Synthesis and Properties of Aromatic Compounds
2014 - Royal Society of Chemistry | Chemical Communications
Takashi Kawasuji, Brian A. Johns, Hiroshi Yoshida, Jason G. Weatherhead, Toshiyuki Akiyama, Teruhiko Taishi, Yoshiyuki Taoda, Minako Mikamiyama-Iwata, Hitoshi Murai, Ryuichi Kiyama, Masahiro Fuji, Norihiko Tánimoto, Tomokazu Yoshinaga, Takahiro Seki, Masanori Kobayashi, Akihiko Sato, Edward P. Garvey, Tamio Fujiwara,
This work is a continuation of our initial discovery of a potent monocyclic carbamoyl pyridone human immunodeficiency virus type-1 (HIV-1) integrase inhibitor that displayed favorable antiviral and pharmacokinetic properties. We report herein a series of bicyclic carbamoyl pyridone analogues to address conformational issues from our initial SAR studies. This modification of the core unit succeeded to deliver low nanomolar potency in standard antiviral assays. An additional hydroxyl substituent on ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2013 - American Chemical Society | Journal of Medicinal Chemistry
Brian A. Johns, Takashi Kawasuji, Jason G. Weatherhead, Teruhiko Taishi, David P. Temelkoff, Hiroshi Yoshida, Toshiyuki Akiyama, Yoshiyuki Taoda, Hitoshi Murai, Ryuichi Kiyama, Masahiro Fuji, Norihiko Tánimoto, Jerry Jeffrey, Scott A. Foster, Tomokazu Yoshinaga, Takahiro Seki, Masanori Kobayashi, Akihiko Sato, Matthew N. Johnson, Edward P. Garvey, Tamio Fujiwara,
We report herein the discovery of the human immunodeficiency virus type-1 (HIV-1) integrase inhibitors dolutegravir (S/GSK1349572) (3) and S/GSK1265744 (4). These drugs stem from a series of carbamoyl pyridone analogues designed using a two-metal chelation model of the integrase catalytic active site. Structure-activity studies evolved a tricyclic series of carbamoyl pyridines that demonstrated properties indicative of once-daily dosing and superior potency against resistant viral strains. An inherent ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2013 - American Chemical Society | Journal of Medicinal Chemistry
Tomokazu Yoshinaga, Takahiro Seki, Shigeru Miki, Tadashi Miyamoto, Akemi Suyama-Kagitani, Shinobu Kawauchi-Miki, Masanori Kobayashi, Akihiko Sato, Eugene L. Stewart, Mark Underwood, Tamio Fujiwara,
Cabotegravir (CAB, S/GSK1265744) is an investigational second-generation integrase strand transfer inhibitor (INSTI) with a chemical structure similar to dolutegravir. CAB is under development as a long-acting injectable formulation for treatment of HIV-1 infection and for pre-exposure prophylaxis. We conducted an in vitro passage study of raltegravir- or elvitegravir-resistant signature mutants in the presence of CAB to characterize the resistance profile of this drug. During passage with Q148H virus, ...
Tópico(s): Biochemical and Molecular Research
2018 - Elsevier BV | Antiviral Research
Masaru Nakagawa, Daisuke Ishii, K. Aoki, Takahiro Seki, Tomokazu Iyoda,
Morphology-controlled nickel– phosphorus hollow microfibers (see Figure) have been fabricated by electroless plating using hydrogen-bonded fibrous molecular aggregates as novel morphology-tunable and recyclable templates. The inner diameter and the tubular morphology are tunable by simply varying the amphoteric azopyridine carboxylic acids forming the fibrous molecular aggregates.
Tópico(s): Electrocatalysts for Energy Conversion
2005 - | Advanced Materials
Shuichi Sugiyama, Toshiyuki Akiyama, Yoshiyuki Taoda, Tsutomu Iwaki, Eriko Matsuoka, Erika Akihisa, Takahiro Seki, Tomokazu Yoshinaga, Takashi Kawasuji,
We have discovered HIV-1 novel integrase-LEDGF/p75 allosteric inhibitors (INLAIs) based on a pyridine scaffold forming an intramolecular hydrogen bond. Scaffolds containing a pyridine moiety have been studied extensively and we have already reported that substituents extending from the C1 position contributed to the antiviral potency. In this study, we designed a new pyridine scaffold 2 with a substituent at the C1 position. Interestingly, during attempts at optimization, we found that the direction ...
Tópico(s): Hepatitis C virus research
2020 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
Kazuhiro Yasuda, Tomokazu Yamamoto, Shu Seki, K. Shiiyama, Shinya Matsumura,
This paper investigates the formation process of radiation-induced defects in magnesium aluminate spinel and their stability using transmission electron microscopy, with emphasis on the effects of electronic excitation. Small interstitial-type dislocation loops disappeared under electron-induced electronic excitation. The elimination rate of the loops was found to be one order higher than for α-alumina. The disappearance of dislocation loops by a dissociation mechanism into isolated interstitials ...
Tópico(s): Geophysical Methods and Applications
2008 - Elsevier BV | Nuclear Instruments and Methods in Physics Research Section B Beam Interactions with Materials and Atoms
Takanori Kobayashi, Kanekazu Seki, Tomokazu Tanaka, Toshiyuki Takayanagi,
Tópico(s): Advanced Chemical Physics Studies
2010 - Elsevier BV | Computational and Theoretical Chemistry
Fuminori Yamada, Yoichi Hiramatsu, Tomokazu Murata, Yoichi Seki, Mizue Yokoo, Remi Noguchi, Takayuki Shibuya, Mari Tanaka, Rieko Takanashi, Eiji Shimizu,
Background Mental imagery has a more powerful impact on our emotions than thinking in words about the same material. Treating intrusive images with imagery rescripting ( IR ) has been reported for various disorders, including post‐traumatic stress disorder, social anxiety disorder, and bipolar disorder. There has been less research about IR as a major depressive disorder ( MDD ). Aims We examined whether IR without focusing on early traumatic memories is effective in MDD . Methods We enrolled 19 participants ...
Tópico(s): Psychosomatic Disorders and Their Treatments
2017 - Wiley | Psychology and Psychotherapy Theory Research and Practice
Tomokazu Umeyama, Noriyasu Tezuka, Shu Seki, Yoshihiro Matano, Masayuki Nishi, Kazuyuki Hirao, Heli Lehtivuori, Nikolai V. Tkachenko, Helge Lemmetyinen, Yoshihide Nakao, Shigeyoshi Sakaki, Hiroshi Imahori,
For the first time nanocarbon composites with C70 molecules aligned on the sidewall of single-walled carbon nanotubes (SWNTs) are demonstrated. The C70–SWNT photoelectrochemical devices exhibit efficient photocurrent generation properties that result from selective formation of a single composite film consisting of a SWNT network covered with C70 molecules and high electron mobility through the C70–SWNT network. Detailed facts of importance to specialist readers are published as "Supporting Information". ...
Tópico(s): Molecular Junctions and Nanostructures
2010 - | Advanced Materials
Hironobu Hayashi, Wataru Nihashi, Tomokazu Umeyama, Yoshihiro Matano, Shu Seki, Yo Shimizu, Hiroshi Imahori,
Liquid crystalline donor (i.e., phthalocyanine) was covalently linked to acceptor (i.e, fullerene) to achieve efficient charge-transport properties in a liquid crystalline phase. The columnar structure exhibited highly efficient ambipolar charge-transport character, demonstrating the potential utility of the strategy in organic electronics.
Tópico(s): Organic Electronics and Photovoltaics
2011 - American Chemical Society | Journal of the American Chemical Society
Tomokazu Yoshinaga, Masanori Kobayashi, Takahiro Seki, Shigeru Miki, Chiaki Wakasa-Morimoto, Akemi Suyama-Kagitani, Shinobu Kawauchi-Miki, Teruhiko Taishi, Takashi Kawasuji, Brian A. Johns, Mark Underwood, Edward P. Garvey, Akihiko Sato, Tamio Fujiwara,
ABSTRACT GSK1265744 is a new HIV integrase strand transfer inhibitor (INSTI) engineered to deliver efficient antiviral activity with a once-daily, low-milligram dose that does not require a pharmacokinetic booster. The in vitro antiviral profile and mechanism of action of GSK1265744 were established through integrase enzyme assays, resistance passage experiments, and cellular assays with site-directed molecular (SDM) HIV clones resistant to other classes of anti-HIV-1 agents and earlier INSTIs. GSK1265744 ...
Tópico(s): Biochemical and Molecular Research
2014 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Junko Aimi, Motonori Komura, Tomokazu Iyoda, Akinori Saeki, Shu Seki, Masayuki Takeuchi, Takashi Nakanishi,
Novel block copolymers bearing a phthalocyanine were synthesized via atom transfer radical polymerization and “click” chemistry. Self-assembled nanoarchitectures are obtained through microphase separation of the block copolymers and phthalocyanine π–π interactions.
Tópico(s): Surface Chemistry and Catalysis
2015 - Royal Society of Chemistry | Journal of Materials Chemistry C
Kazuomi Kario, Yoshiaki Yokoi, Keisuke Okamura, Masahiko Fujihara, Yukako Ogoyama, Eiichiro Yamamoto, Hidenori Urata, Jin Man Cho, Chong Jin Kim, Seung‐Hyuk Choi, Keisuke Shinohara, Yasushi Mukai, Tomokazu Ikemoto, Masato Nakamura, Shuichi Seki, Satoaki Matoba, Yoshisato Shibata, Shigeo Sugawara, Kazuhiko Yumoto, Kouichi Tamura, Fumiki Yoshihara, Satoko Nakamura, Woong Chol Kang, Taro Shibasaki, Keigo Dote, Hiroyoshi Yokoi, Akiko Matsuo, Hiroshi Fujita, Toshiyuki Takahashi, Hyun‐Jae Kang, Yasushi Sakata, Kazunori Horie, Naoto Inoue, Ken-ichiro Sasaki, Takafumi Ueno, Hirofumi Tomita, Yoshihiro Morino, Yuhei Nojima, Chan Joon Kim, Tomoaki Matsumoto, Hisashi Kai, Shinsuke Nanto,
Abstract Renal denervation is a promising new non-pharmacological treatment for resistant hypertension. However, there is a lack of data from Asian patients. The REQUIRE trial investigated the blood pressure-lowering efficacy of renal denervation in treated patients with resistant hypertension from Japan and South Korea. Adults with resistant hypertension (seated office blood pressure ≥150/90 mmHg and 24-hour ambulatory systolic blood pressure ≥140 mmHg) with suitable renal artery anatomy were randomized ...
Tópico(s): Hemodynamic Monitoring and Therapy
2021 - Springer Nature | Hypertension Research
Hironobu Hayashi, Wataru Nihashi, Tomokazu Umeyama, Yoshihiro Matano, Shu Seki, Yo Shimizu, Hiroshi Imahori,
... Efficient Ambipolar Charge Transport"Hironobu Hayashi, Wataru Nihashi, Tomokazu Umeyama, Yoshihiro Matano, Shu Seki*, Yo Shimizu*, and Hiroshi Imahori*Cite this: J. ...
Tópico(s): Plant Reproductive Biology
2017 - American Chemical Society | Journal of the American Chemical Society
Tomokazu Seki, Kousuke Baba, Tomohiro Hayashi, Risako Furuta, Hiroaki Hirosawa, Taichi Mitsui, Hiroki Maesaka, Syuhei Takasawa, Toshiro Miwa, Keiko Tanaka, Yuji Nakatsuji,
A 68-year-old man with small-cell lung cancer developed anti-collapsin response-mediator protein (CRMP)-5 antibody-related paraneoplastic neurological syndrome (PNS) presenting with ataxia and chorea during treatment with durvalumab. As a result of steroid therapy, anti-CRMP-5 antibodies became negative, hyperintense lesions on brain magnetic resonance imaging disappeared, and neurological symptoms improved. After resuming durvalumab, he became unable to walk due to neurological adverse events (nAEs). ...
Tópico(s): Melanoma and MAPK Pathways
2023 - The Japanese Society of Internal Medicine | Internal Medicine
Tomokazu Umeyama, Noriyasu Tezuka, Fumiaki Kawashima, Shu Seki, Yoshihiro Matano, Yoshihide Nakao, Tetsuya Shishido, Masayuki Nishi, Kazuyuki Hirao, Heli Lehtivuori, Nikolai V. Tkachenko, Helge Lemmetyinen, Hiroshi Imahori,
Grain wiring: Functionalized single-wall carbon nanotube wiring between the nanograins of porphyrin (donor)–C60 (acceptor) dyads results in efficient charge transport between them, leading to the highest incident photon-to-current efficiency (22 %) ever reported for analogous photoelectrochemical devices utilizing donor–acceptor linked dyads. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They ...
Tópico(s): Porphyrin and Phthalocyanine Chemistry
2011 - Wiley | Angewandte Chemie International Edition
Tomokazu Umeyama, Kensho Igarashi, Daisuke Sakamaki, Shu Seki, Hiroshi Imahori,
The effects of regioisomer and diastereomer separations of [70]PCBM on structures and photovoltaic properties of PffBT4T-2OD:[70]PCBM blend films have systematically been investigated for the first time. Decreasing the amount of a diastereomer of β-[70]PCBM with high aggregation tendency (β1-[70]PCBM) improved the photovoltaic performances.
Tópico(s): Carbon Nanotubes in Composites
2017 - Royal Society of Chemistry | Chemical Communications
Shuichi Sugiyama, Tsutomu Iwaki, Yoshinori Tamura, Kenji Tomita, Eriko Matsuoka, Shuhei Arita, Takahiro Seki, Tomokazu Yoshinaga, Takashi Kawasuji,
We report herein the discovery of novel integrase-LEDGF/p75 allosteric inhibitors (INLAIs) based on a benzene scaffold 3. This scaffold can extend substituents from the C1 position unlike the common pyridine scaffolds 2. Structure-activity relationship studies showed that the sulfonamide linker at the C1 position was important for the antiviral activity. Interaction between sulfonamide and Q95 was observed by X-ray crystallography. Compound 31h showed more potent antiviral activity (EC50 (NL432) = 3. ...
Tópico(s): HIV Research and Treatment
2020 - Elsevier BV | Bioorganic & Medicinal Chemistry
Shoji Akai, Hidehito Seki, Naoki Sugita, Tomokazu Kogure, Naoki Nishizawa, Katsuhiko Suzuki, Yutaka Nakamura, Yasuhiro Kajihara, Juji Yoshimura, Ken‐ichi Sato,
Abstract Total synthesis of (−)-tetrodotoxin (TTX) from d-glucose is described. As a critical transformation step for synthesizing TTX, a key multi-functionalized cyclitol was prepared from d-glucose employing the Ferrier(II) reaction. Stereospecific introduction of three functionalized branched chains were achieved via Peterson olefination and spiro α-chloroepoxidation of the corresponding carbonyl derivatives.
Tópico(s): Synthetic Organic Chemistry Methods
2010 - Oxford University Press | Bulletin of the Chemical Society of Japan
Taishi Umezawa, Masanori Okamoto, Tetsuo Kushiro, Eiji Nambara, Youko Oono, Motoaki Seki, Masatomo Kobayashi, Tomokazu Koshiba, Yuji Kamiya, Kazuo Shinozaki,
Abscisic acid (ABA) catabolism is one of the determinants of endogenous ABA levels affecting numerous aspects of plant growth and abiotic stress responses. The major ABA catabolic pathway is triggered by ABA 8'-hydroxylation catalysed by the cytochrome P450 CYP707A family. Among four members of Arabidopsis CYP707As, the expression of CYP707A3 was most highly induced in response to both dehydration and subsequent rehydration. A T-DNA insertional cyp707a3-1 mutant contained higher ABA levels in turgid ...
Tópico(s): Photosynthetic Processes and Mechanisms
2006 - Wiley | The Plant Journal
Chin Piow Wong, Ari Seki, Kaori Horiguchi, Tomokazu Shoji, Takashi Arai, Alfarius Eko Nugroho, Yusuke Hirasawa, Fumiaki Sato, Toshio Kaneda, Hiroshi Morita,
We have previously reported that bisleuconothine A (Bis-A), a novel bisindole alkaloid isolated from Leuconotis griffithii, showed cytostatic activity in several cell lines. In this report, the mechanism of Bis-A-induced cytostatic activity was investigated in detail using A549 cells. Bis-A did not cause apoptosis, as indicated by analysis of annexin V and propidium iodide staining. Expression of all tested apoptosis-related proteins was also unaffected by Bis-A treatment. Bis-A was found to increase ...
Tópico(s): Calcium signaling and nucleotide metabolism
2015 - American Chemical Society | Journal of Natural Products
Jinseok Baek, Tomokazu Umeyama, Wookjin Choi, Yusuke Tsutsui, Hiroki Yamada, Shu Seki, Hiroshi Imahori,
Abstract Composite films that consisted of C 60 and well‐exfoliated nanosheets of transition metal dichalcogenides (TMDs), such as MoS 2 or WS 2 , with a bulk heterojunction structure were easily fabricated onto a semiconducting SnO 2 electrode via a two‐step methodology: self‐assembly into their composite aggregates by injection of a poor solvent into a good solvent with the dispersion, and subsequent electrophoretic deposition. Upon photoexcitation, the composites on SnO 2 exhibited enhanced transient ...
Tópico(s): Perovskite Materials and Applications
2017 - Wiley | Chemistry - A European Journal