Keiko Miyamoto, Fumiya Kawase, Tomoko Imai, Ayako Sezaki, Hiroshi Shimokata,
Tópico(s): Obesity, Physical Activity, Diet
2018 - Springer Nature | European Journal of Clinical Nutrition
Hidemitsu Pan‐Hou, Masako Kiyono, Tomoka Kawase, Tomoko Omura, Ginro Endo,
To evaluate the utility of polyphosphate kinase gene (ppk)-specified polyphosphate in mercury remediation, a fusion plasmid, pMK27, with ppk from Klebsiella aerogenes and mercury transport genes, merT and merP, from Pseudomonas K-62, was constructed. The transcription and translation of ppk, merT and merP were found to be mercury-inducible. The ppk-specified polyphosphate was identified in cells preinduced by Hg2+, but not in cells without mercury induction, suggesting that the synthesis of polyphosphate ...
Tópico(s): Adsorption and biosorption for pollutant removal
2001 - Pharmaceutical Society of Japan | Biological and Pharmaceutical Bulletin
Fusao Kimizuku, Yuki Taguchi, Yoichi Ohdate, Yasutoshi Kawase, Tomoko Shimojo, Kimikazu Hashino, Ikunoshin Kato, Kiyotoshi Sekiguchi, Koiti Titani,
An efficient expression system was constructed in Escherichia coli that produced a 33-kDa fragment, C-274, of human fibronectin with a strong cell-adhesive activity. The entire sequence of the heparin-binding domain with 271 amino acids, H-271, was also expressed. Deletion analysis of the type III repeats showed that the heparin-binding site was at type III-13. The cell-adhesive activity of a fusion protein, CH-271, containing the cell- and the heparin-binding domains was twice that of C-274 when ...
Tópico(s): Protease and Inhibitor Mechanisms
1991 - Oxford University Press | The Journal of Biochemistry
Fusao Kimizuka, Yoichi Ohdate, Yasutoshi Kawase, Tomoko Shimojo, Yuzuru Taguchi, Kimikazu Hashino, S Goto, Hidetaka Hashi, Itaru Kato, Kiyotoshi Sekiguchi,
Recombinant fibronectin (FN) fragments and their mutant proteins were produced to elucidate the role of type I11 homology repeats in cell adhesive activity within the cell-binding domain of FN. Cell adhesive activity of the 11.5-kDa fragment, the cell attachment site of the cell-binding domain, was <0.1% that of native FN despite the presence of the Arg-Gly-Asp-Ser sequence.The activity increased as type I11 homology repeats were added to the N terminus of the 11.5-kDa fragment, and a 52-kDa fragment ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
1991 - Elsevier BV | Journal of Biological Chemistry
Tomoko Kawase, Manabu Okamoto, Takaaki Fukutomi, Yamato Takahashi,
Consumer electronics equipped with a microphone array, such as car navigation devices and headsets commonly implement speech enhancement techniques based on the gradient method to cope with additive noise. However, while these techniques had been originally developed for voice communication and can maximize the signal-to-distortion ratio (SDR), they cannot always maximize automatic speech recognition (ASR) accuracy. For this reason, the front-end speech enhancement parameters have been adjusted by ...
Tópico(s): Advanced Adaptive Filtering Techniques
2020 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Consumer Electronics
K. M. Nair, Q. X. Jia, Shashank Priya,
... Sr2NaNb5O15 Piezoelectric Ceramics 91 Satoshi Tanaka, Takuma Takahashi, Tomoko Kawase, Ryoichi Furushima, Hiroyuki Shimizu, Yutaka Doshida, and Keizo ...
Tópico(s): Smart Materials for Construction
2011 - Wiley | Ceramic transactions /Ceramic transactions
Satoshi Tanaka, Atsushi Makiya, Takeshi Okada, Tomoko Kawase, Zenji Kato, Keizo Uematsu,
We fabricated c ‐axis‐oriented KSr 2 Nb 5 O 15 (KSN) ceramics using a rotating strong magnetic field with subsequent sintering. The degree of orientation of the green compact was about 0.1 for (00 l ), as evaluated from the Lotgering factor in X‐ray diffraction. The orientation of the structure was enhanced by sintering at 1673 K; the Lotgering factor of the sintered body increased to 0.8. Microstructural examination indicated a well‐oriented structure in which the longitudinal axes of the rectangular‐ ...
Tópico(s): Acoustic Wave Resonator Technologies
2007 - Wiley | Journal of the American Ceramic Society
Shinkiti Koto, Naohiko Morishima, Kazuhiro Takenaka, Kumi Kanemitsu, Noriko Shimoura, Miyuki Kase, Shizuko Kojiro, Teiko Nakamura, Tomoko Kawase, Shonosuke Zen,
Abstract A variety of benzylated 1-OH derivatives, having an acetyl or an allyl group, of d-glucose, d-galactose, d-mannose, d-xylose, l-arabinose, l-fucose, and l-rhamnose, were synthesized from the corresponding protected 2-methoxyethyl glycosides through a brief treatment with TiCl4 in dichloromethane and a subsequent hydrolysis of the intermediary 1-Cl derivatives on a silica-gel column.
Tópico(s): Polyamine Metabolism and Applications
1989 - Oxford University Press | Bulletin of the Chemical Society of Japan
Takahiko Fujikawa, Kenji Tamura, Tomoko Kawase, Yoshiko Mori, Randall R. Sakai, Kunihiro Sakuma, Akihiko Yamaguch, Masato Ogata, Hideaki Soya, Kunio Nakashima,
Under acute stress conditions in the rat, there is rapid and transient increase in circulating prolactin (PRL). This leads to an elevated expression of the long form of PRLR (PRLR-L) first in the hypothalamus and the choroid plexus. This increase in PRL is involved in the inhibition of stress-induced hypocalcemia and gastric erosion. In this study we used rat PRL and a PRLR morpholino-antisense oligonucleotide to elucidate the mechanism by which hypothalamic PRLR mediates the inhibition of restraint ...
Tópico(s): Growth Hormone and Insulin-like Growth Factors
2005 - Oxford University Press | Endocrinology
Yukihiro Isogai, Tomoko Kawase, Hideharu Ishida, Makoto Kiso, Akira Hasegawa,
ABSTRACT 3-O-Sulfo glucuronyl paragloboside derivatives (pentasaccharides) have been synthesized. The important intermediate designed for a facile sulfation in the last step and effective, stereocontrolled glycosidation, methyl (4-O-acetyl-2-O-benzoyl-3-O-levulinoyl-α-D-glucopyranosyl trichloroacetimidate)uronate (8) was prepared from methyl [2-(trimethylsilyl)ethyl β-D-glucopyranosid]uronate (3) via selective 4-O-acetylation, 2-O-benzoylation, 3-O-levulinoylation, removal of the 2-(trimethylsilyl)ethyl ...
Tópico(s): Proteoglycans and glycosaminoglycans research
1996 - Taylor & Francis | Journal of Carbohydrate Chemistry
Yasutoshi Kawase, Yoichi Ohdate, Tomoko Shimojo, Yuki Taguchi, Fusao Kimizuka, Ikunoshin Kato,
An efficient expression system was constructed for C‐EGF, a fusion protein made of a fragment of the cell‐binding domain of human fibronectin (FN) bound with epidermal growth factor (EGF), C‐EGF was produced in Escherichia coli HB101 cells carrying the recombinant plasmid pCE102 as inclusion bodies, which were solubilized and refolded after purification. C‐EGF had both cell‐adhesive and EGF activities, so it might be more effective than EGF in therapeutic applications. This fusion system would be ...
Tópico(s): Peptidase Inhibition and Analysis
1992 - Wiley | FEBS Letters
Takashi Makabe, I Saiki, J Murata, Yoichi Ohdate, Yasutoshi Kawase, Yuzuru Taguchi, Tomoko Shimojo, Fusao Kimizuka, Itaru Kato, Ichiro Azuma,
We utilized recombinant fibronectin polypeptides with cell-binding domain and heparin-binding domains (referred to as C-274 and H-271, respectively) and their fusion polypeptide (CH-271) to examine the role of sulfated polysaccharide heparin and/or the functional domains of fibronectin in modulating tumor cell behavior. Both C-274 and CH-271 polypeptides with cell-binding domains promoted the adhesion and migration of B16-BL6 melanoma cells, whereas H-271 did not. Heparin bound to the immobilized ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
1990 - Elsevier BV | Journal of Biological Chemistry
Ikuo Saiki, Jun Murata, Takashi Makabe, Yoshihiro Matsumoto, Yoichi Ohdate, Yasutoshi Kawase, Yuki Taguchi, Tomoko Shimojo, Fusao Kimizuka, Ikunoshin Kato, Ichiro Azuma,
We have investigated the antimetastatic effect of synthetic or recombinant peptides containing the functional domains of fibronectin on experimental and spontaneous lung metastases of murine tumor cells. CS1 peptide which is present within type III homology connecting segment (IIICS) as well as C‐274 (cell‐binding domain) were able to inhibit experimental lung metastasis when co‐injected intravenously (iv) with B16‐BL6 melanoma cells, while H‐271 (heparin‐binding domain) could not. In the spontaneous ...
Tópico(s): RNA Interference and Gene Delivery
1990 - Oxford University Press | Japanese Journal of Cancer Research
Kenji Hotta, Tomoko Kawase, Hideharu Ishida, Makoto Kiso, Akira Hasegawa,
Abstract A first total synthesis of a β-series ganglioside GQ1β (IV3Neu5Acα2, III6Neu5Acα2-Gg4Cer) is described. Regio- and stereoselective dimeric sialylation of the hydroxyl group at C-6 of the GalNAc residue in 2-(trimethylsilyl)ethyl O-(2-acetamido-2-deoxy-3-O-levulinyl-β-d-galactopyranosyl)-(1→4)-O-(2,3,6-tri-O-benzyl-β-d-galactopyranosyl)-(1→4)-O-2,3,6-tri-O-benzyl-β-d-glucopyranoside (3) with methyl [phenyl 5-acetamido-8-O-(5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-d-glycero-α-d-galacto- ...
Tópico(s): Proteoglycans and glycosaminoglycans research
1995 - Taylor & Francis | Journal of Carbohydrate Chemistry
Y. Kawase, Akira Hirata, Tomoko Kojima, Sadao Ohmori, Hironobu AKUTAGAWA, Koji Uehara, Katsuki Iwata, Tsunenori Nakajima, K. Yamamoto,
As a microbial-environmental-control-type deodorizing system, we have developed a compact biotrickling filter system for small-scale livestock farms. The performance of the compact co-current biotrickling filter operated at high recycle liquid flow rates was systematically examined. In particular, we studied improvements in the nitrification ability of the system due to the resultant enhancement of absorption and dissolution of NH3 and absorption of O2 with the high flow rates of recycle liquid ...
Tópico(s): Surface Modification and Superhydrophobicity
2014 - Elsevier BV | Process Biochemistry
Chikage Suzuki, Yoshiki Murakumo, Yukari Kawase, Tomoko Sato, Takatoshi Morinaga, Naoyuki Fukuda, Atsushi Enomoto, Masatoshi Ichihara, Masahide Takahashi,
The Krüppel-associated box (KRAB)-containing zinc finger proteins (ZFPs) comprise the largest family of zinc finger transcription factors that function as transcriptional repressors. In the study of glial cell line-derived neurotrophic factor (GDNF)-RET signaling, we have identified bone marrow zinc finger 3 (BMZF3), encoding a KRAB-ZFP, as a GDNF-inducible gene by differential display analysis. The expression of BMZF3 transcripts in the human neuroblastoma cell line TGW increased 1h after GDNF stimulation, ...
Tópico(s): Nuclear Structure and Function
2007 - Elsevier BV | Biochemical and Biophysical Research Communications
Masashi Ikeda, Atsushi Takahashi, Yoichiro Kamatani, Yukihide Momozawa, Takeo Saito, Kenji Kondo, Ayu Shimasaki, Kohei Kawase, Takaya Sakusabe, Yoshimi Iwayama, Tomoko Toyota, Tomoyasu Wakuda, Mitsuru Kikuchi, Nobuhisa Kanahara, Hidenaga Yamamori, Yuka Yasuda, Yuichiro Watanabe, Satoshi Hoya, Branko Aleksić, Itaru Kushima, Heii Arai, Manabu Takaki, Kotaro Hattori, Hiroshi Kunugi, Yuko Okahisa, Tohru Ohnuma, Norio Ozaki, Toshiyuki Someya, Ryota Hashimoto, Takeo Yoshikawa, Michiaki Kubo, Nakao Iwata,
Genome-wide association studies (GWASs) have identified >100 susceptibility loci for schizophrenia (SCZ) and demonstrated that SCZ is a polygenic disorder determined by numerous genetic variants but with small effect size. We conducted a GWAS in the Japanese (JPN) population (a) to detect novel SCZ-susceptibility genes and (b) to examine the shared genetic risk of SCZ across (East Asian [EAS] and European [EUR]) populations and/or that of trans-diseases (SCZ, bipolar disorder [BD], and major depressive disorder [ ...
Tópico(s): Genomics and Rare Diseases
2018 - Oxford University Press | Schizophrenia Bulletin
Yoshiyuki Kawase, Tomoko Okada, Toshio Miwa,
Abstract The acetylation of methyl 2,3-dimethyl-4- and -7-benzofurancarboxylates was carried out by the action of acetyl chloride and aluminum chloride in carbon disulfide at room temperature to afford the 6-acetyl compounds; these compounds were converted to keto-acids by hydrolysis, and then to the known dicarboxylic acid or to the known 6-acetylbenzofuran. The alkylation of acetyl and methoxycarbonyl derivatives of 2,3-dimethylbenzofuran was carried out by the action of n- or iso-propyl bromide ...
Tópico(s): Multicomponent Synthesis of Heterocycles
1970 - Oxford University Press | Bulletin of the Chemical Society of Japan
Zixuan Zhang, Yuta Hasegawa, Daigo Hashimoto, Hajime Senjo, Ryo Kikuchi, Xuanzhong Chen, Kazuki Yoneda, Tomoko Sekiguchi, Tatsuya Kawase, Hirofumi Tsuzuki, Takashi Ishio, Takahide Ara, Hiroyuki Ohigashi, Masao Nakagawa, Takanori Teshima,
Allogeneic hematopoietic stem cell transplantation (allo-SCT) is a potentially curative therapy for FLT3 internal tandem duplication mutant (FLT3-ITD+) acute myeloid leukemia, but relapse rate is high. A recent study showed that sorafenib, a first generation FLT3 and multikinase inhibitor, enhanced graft-versus-leukemia (GVL) effects against FLT3-ITD+ leukemia via interleukin-15 (IL-15) production. However, it remains to be clarified whether this effect could be mediated by selective FLT3 inhibition. ...
Tópico(s): Immune Cell Function and Interaction
2022 - Springer Nature | Bone Marrow Transplantation
Shinichiro Fujimori, Manabu Abe, Tsuguki Kinoshita, Tomoko Hasegawa, Hiroaki Kawase, Kazuhide Kushida, Toshihiko Masui, Kazutaka Oka, Hideo Shiogama, Kiyoshi Takahashi, Hiroaki Tatebe, Minoru Yoshikawa,
In climate change research, future scenarios of greenhouse gas and air pollutant emissions generated by integrated assessment models (IAMs) are used in climate models (CMs) and earth system models to analyze future interactions and feedback between human activities and climate. However, the spatial resolutions of IAMs and CMs differ. IAMs usually disaggregate the world into 10-30 aggregated regions, whereas CMs require a grid-based spatial resolution. Therefore, downscaling emissions data from IAMs ...
Tópico(s): Atmospheric and Environmental Gas Dynamics
2017 - Public Library of Science | PLoS ONE
Noboru Motohashi, Hidetsugu Wakabayashi, Teruo Kurihara, Hidetaka Fukushima, Tomoko Yamada, Masami Kawase, Yoshitaka Sohara, Satoru Tani, Yoshiaki Shirataki, Hiroshi Sakagami, Kazue Satoh, Hideki Nakashima, Annamária Molnár, Gabriella Spengler, Nóra Gyémánt, Katalin Ugocsai, Joséph Molnár,
Abstract Fractionation of barbados cherry (acerola fruit, a fruit of Malpighia emarginata DC.) extracts were performed by organic solvent extractions and column chromatographies, using two extraction methods. Higher cytotoxic activity was concentrated in fractions A4 and A6 (acetone extract), and H3 and HE3 (hexane extract). These four fractions showed higher cytotoxic activity against tumor cell lines such as human oral squamous cell carcinoma (HSC‐2) and human submandibular gland carcinoma (HSG), when ...
Tópico(s): Natural product bioactivities and synthesis
2004 - Wiley | Phytotherapy Research
Bharati Joglekar, Tomoko Miyake, Ritsu Kawase, Katsuyoshi Shibata, Hiroshige Muramatsu, Masaki Matsui,
4-Substituted (perfluoroalkylsulfonyl)benzenes have been synthesized by the oxidation of 4-substituted (perfluoroalkylthio)benzenes with hydrogen peroxide, anhydrous chromic oxide and potassium permanganate in good yields. 4-(Perfluoroalkylsulfonyl) anilines have been also prepared by the reduction of the corresponding nitrobenzenes.
Tópico(s): Synthesis and properties of polymers
1995 - Elsevier BV | Journal of Fluorine Chemistry
Kazumi Kawase, Kyoko Nomura, Ryuji Tominaga, Hirotaka Iwase, Tomoko Ogawa, Ikuko Shibasaki, Mitsuo Shimada, Tomoaki Taguchi, Emiko Takeshita, Yasuko Tomizawa, Sachiyo Nomura, Kazuhiro Hanazaki, Tomoko Hanashi, Hiroko Yamashita, Norihiro Kokudo, Kotaro Maeda,
Tópico(s): Dental Education, Practice, Research
2017 - Springer Science+Business Media | Surgery Today
Kazumi Kawase, Kyoko Nomura, Ryuji Tominaga, Hirotaka Iwase, Tomoko Ogawa, Ikuko Shibasaki, Mitsuo Shimada, Tomoaki Taguchi, Emiko Takeshita, Yasuko Tomizawa, Sachiyo Nomura, Kazuhiro Hanazaki, Tomoko Hanashi, Hiroko Yamashita, Norihiro Kokudo, Kotaro Maeda,
Tópico(s): Global Health Workforce Issues
2017 - Springer Science+Business Media | Surgery Today
Toshio Demitsu, Masaaki Kawase, Kazutaka Nagashima, Maya Takazawa, Tomoko Yamada, Maki Kakurai, Naoka Umemoto, Yoshionori Jinbu,
The Journal of DermatologyVolume 46, Issue 1 p. e38-e39 Letter to the Editor Mycoplasma pneumoniae-associated mucositis with severe blistering stomatitis and pneumonia successfully treated with azithromycin and infusion therapy Toshio Demitsu, Corresponding Author Toshio Demitsu demitsu@omiya.jichi.ac.jp orcid.org/0000-0002-4771-6255 Department of Dermatology, Jichi Medical University Saitama Medical Center, Saitama, JapanCorrespondence: Toshio Demitsu, M.D., Department of Dermatology, Jichi Medical ...
Tópico(s): Autoimmune and Inflammatory Disorders
2018 - Wiley | The Journal of Dermatology
Kazumi Kawase, Kyoko Nomura, Sachiyo Nomura, Sadako Akashi‐Tanaka, Tomoko Ogawa, Ikuko Shibasaki, Mitsuo Shimada, Tomoaki Taguchi, Emiko Takeshita, Yasuko Tomizawa, Kazuhiro Hanazaki, Tomoko Hanashi, Hideko Yamauchi, Hiroko Yamashita, Seigo Nakamura,
Tópico(s): Healthcare Systems and Challenges
2020 - Springer Science+Business Media | Surgery Today
Nobuki Maki, Wataru Nishie, Maya Takazawa, Maki Kakurai, Tomoko Yamada, Naoka Umemoto, Masaaki Kawase, Kentaro Izumi, Hiroshi Shimizu, Toshio Demitsu,
Bullous pemphigoid (BP) is a common autoimmune blistering disorder with unknown etiology. Recently, increasing numbers of BP cases which developed under the medication with dipeptidyl peptidase-4 inhibitors (DPP4i), widely used antihyperglycemic drugs, have been reported in published works. Here, we report a case of DPP4i (teneligliptin)-associated BP that developed in a 70-year-old Japanese man. Interestingly, the patient had acquired reactive perforating collagenosis (ARPC), which is also known to ...
Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema
2018 - Wiley | The Journal of Dermatology
Tadao Akizawa, Yoshiharu Tsubakihara, Masaomi Nangaku, Yukihiro Endo, Hiromu Nakajima, Tomoko Kohno, Yukiko Imai, Natsumi Kawase, Katsutoshi Hara, John J. Lepore, Alexander R. Cobitz,
Daprodustat (GSK1278863) is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor being developed for treatment of anemia associated with chronic kidney disease (CKD). The effect of daprodustat in Japanese CKD patients with anemia has not been previously investigated.We evaluated the relationship between daprodustat dose and hemoglobin response in Japanese patients on hemodialysis (HD) with anemia in a 4-week, phase II, double-blind, placebo-controlled study. After interrupting their erythropoiesis- ...
Tópico(s): Chronic Kidney Disease and Diabetes
2016 - Karger Publishers | American Journal of Nephrology
Kosuke Mori, Takao Yoshihara, Y Nishimura, Masaya Uchida, Kaoruko Katsura, Yoshio Kawase, Ikuyoshi Hatano, Hiroyuki Ishida, Tomohiro Chiyonobu, Yasuo Kasubuchi, Akira Morimoto, Tomoko Teramura, Shinsaku Imashuku,
Management of post-transplant complications caused by severe adenoviral infection remains a major therapeutic challenge. A 17-year-old male who had undergone bone marrow transplantation for the treatment of acute lymphoblastic leukemia developed complete anuria following hemorrhagic cystitis 34 days after the transplant procedure. The computed tomogram scan revealed bilateral hydronephrosis, indicating acute renal failure because of obstructive uropathy. The emergency procedure of percutaneous nephrostomy ...
Tópico(s): Herpesvirus Infections and Treatments
2003 - Springer Nature | Bone Marrow Transplantation
Mai Kawase, Tatsuya Toyama, Satoru Takahashi, Shinya Sato, Nobuyasu Yoshimoto, Yumi Wanifuchi‐Endo, Tomoko Asano, Shunzo Kobayashi, Yoshitaka Fujii, Hiroko Yamashita,
Tópico(s): Cancer Cells and Metastasis
2013 - Springer Science+Business Media | Breast Cancer