Masahiro Kanai, Shea J. Andrews, Mattia Cordioli, Christine Stevens, Benjamin M. Neale, Mark J. Daly, Andrea Ganna, Gita A. Pathak, Akiko Iwasaki, Juha Karjalainen, Juha Mehtonen, Matti Pirinen, Karolina Chwiałkowska, Amy Trankiem, Mary K. Balaconis, Kumar Veerapen, Brooke N. Wolford, Hajar Fauzan Ahmad, Shea J. Andrews, Kathrin Aprile von Hohenstaufen Puoti, Cindy G. Boer, Palwendé Romuald Boua, Guillaume Butler‐Laporte, Carmen L. Cadilla, Karolina Chwiałkowska, Francesca Colombo, Venceslas Douillard, Nicole Dueker, Atanu Kumar Dutta, Yasser M. El‐Sherbiny, Madonna M. Eltoukhy, Sahar Esmaeeli, Annika Faucon, Marie-Julie Favé, Israel Fernández Cadenas, Margherita Francescatto, Laurent C. Francioli, Lude Franke, Macarena Fuentes‐Guajardo, Rocío Gallego Durán, David Gómez-Cabrero, Emi N. Harry, Philip R. Jansen, József Szentpéteri, Elżbieta Kaja, Masahiro Kanai, Chloe Kirk, Athanasios Kousathanas, José Eduardo Krieger, Sanjay Patel, Audrey Lemaçon, Sophie Limou, Píetro Lió, Eirini Marouli, M. Marttila, Carolina Medina‐Gómez, Yael Michaeli, Isabelle Migeotte, Soumyajit Mondal, Andrés Moreno‐Estrada, Leire Moya, Tomoko Nakanishi, Jamal Nasir, Dorote Pasko, Nathaniel M. Pearson, Alexandre C. Pereira, James R. Priest, Vid Prijatelj, Ivana Nedeljković, Alexander Teumer, Réka Várnai, Manuel Romero‐Gómez, Christina Roos, Jeffrey Rosenfeld, Ruolin Li, Eva C. Schulte, Claudia Schurmann, Bahareh Sedaghati-khayat, Doaa Shaheen, Ilangumaran Shivanathan, Csilla Sipeky, Zhou Sirui, Pasquale Striano, Yosuke Tanigawa, Alicia Utrilla Remesal, Nirmal Vadgama, Costanza L. Vallerga, Sander W. van der Laan, Ricardo A. Verdugo, Qingbo Wang, Wei Zhou, Ummu Afeera Zainulabid, Ruth N. Zárate, Adam Auton, Janie F. Shelton, Anjali J. Shastri, Catherine H. Weldon, Teresa Filshtein-Sonmez, Daniella Coker, Antony Symons, Stella Aslibekyan, Jared O’Connell, Chelsea Ye, Alexander S. Hatoum, Amit Agrawal, Ryan Bogdan, Sarah M. C. Colbert, Wesley K. Thompson, Chun Fan, Emma C. Johnson, Lyudmila Niazyan, Mher Davidyants, Arsen Arakelyan, Diana Avetyan, Makhabbat Bekbossynova, Ainur Tauekelova, Mukhtar Tuleutayev, Aliya Sailybayeva, Yerlan Ramankulov, Elena Zholdybayeva, Jarkyn Dzharmukhanov, Kuat Kassymbek, Tatyana Tsechoeva, Gulsimzhan Turebayeva, Zauresh Smagulova, Timur Muratov, Sadyk Khamitov, Alex S. F. Kwong, Nicholas J. Timpson, Mari Niemi, Souad Rahmouni, Julien Guntz, Y Beguin, Mattia Cordioli, Sara Pigazzini, Lindokuhle Nkambule, Michel Georges, Michel Moutschen, Benoît Misset, Gilles Darcis, Stéphanie Gofflot, Youssef Bouysran, Adeline Busson, Xavier Peyrassol, Françoise Wilkin, Bruno Pichon, Guillaume Smits, Isabelle Vandernoot, Jean‐Christophe Goffard, Nicky Tiembe, David Morrison, Jonathan Afilalo, Vincent Mooser, J. Brent Richards, Simon Rousseau, Madéleine Durand, Guillaume Butler‐Laporte, Vincenzo Forgetta, Lætitia Laurent, Zaman Afrasiabi, Meriem Bouab, Chris Tselios, Xiaoqing Xue, Marc Afilalo, Maureen Oliveira, Janick St-Cyr, Ariane Boisclair, Jiannis Ragoussis, Daniel Auld, Daniel E. Kaufmann, G. Mark Lathrop, Guillaume Bourque, Simon Décary, Emilia Liana Falcone, Alexandre Montpetit, Alain Piché, Christel Renoux, Natàlia Blay, Sze Man Tse, Ma’n H. Zawati, Lea K. Davis, Nancy J. Cox, Jennifer E. Below, Julia Sealock, Annika Faucon, Megan M. Shuey, Hannah G. Polikowsky, Lauren E. Petty, Douglas M. Shaw, Hung‐Hsin Chen, Wanying Zhu, Axel Schmidt, Kerstin U. Ludwig, Carlo Maj, Selina Rolker, Daniella Balla, Pari Behzad, Markus M. Nöthen, Julia Fazaal, Verena Keitel, Verena Keitel, Björn‐Erik Ole Jensen, Torsten Feldt, Nikolaus Marx, Michael Dreher, Isabell Pink, Markus Cornberg, Thomas Illig, Clara Lehmann, Philipp Schommers, Jan Rybniker, Max Augustin, Lisa Knopp, Ingo Kurth, Thomas Eggermann, Sonja Volland, Marc Moritz Berger, Thorsten Brenner, Anke Hinney, Oliver Witzke, Margarethe Konik, Robert Bals, Christian Herr, Nicole Ludwig, Jörn Walter, Eicke Latz, Susanne V. Schmidt, Jennifer D. Brooks, Shelley B. Bull, Lloyd T. Elliott, France Gagnon, Celia M.T. Greenwood, Rayjean J. Hung, Jerry Lawless, Andrew D. Paterson, Lei Sun, Michael J. Rauh, Laurent Briollais, Anne‐Claude Gingras, Yvonne Bombard, Trevor J. Pugh, Jared T. Simpson, Lee Goneau, Anat R. Halevy, David M. Maslove, Bjug Borgundvaag, Luke Devine, Erin Bearss, David Richardson, Saranya Arnoldo, Steven Friedman, Ahmed Taher, Seth Stern, Marc Dagher, Jovanka Vasilevska‐Ristovska, Catherine M. Biggs, Beata Mickiewicz, Lisa J. Strug, Stephen W. Scherer, Naveed Aziz, Steven J.M. Jones, Bartha Maria Knoppers, Mark Lathrop, Stuart E. Turvey, Rae S. M. Yeung, Upton Allen, Angela M. Cheung, Margaret S. Herridge, Miranda Hunt, Jordan Lerner‐Ellis, Jennifer Taher, Rulan S. Parekh, Linda T. Hiraki, Juthaporn Cowan, Francine M. Ducharme, Mario Ostrowski, François P. Bernier, Jim Kellner, Elika Garg, Samantha Yoo, Caitlyn Vlasschaert, Erika Frangione, Monica Chung, Abdul Noor, Elena Greenfeld, Karen Colwill, Marc Clausen, Gary Chao, FengYun Yue, Marvin J. Fritzler, Joseph Whitney, Bhooma Thiruvahindrapuram, Jean‐Michel Garant, Rohan Abraham, Adrienne D. Davis, Aaron Campigotto,
Investigating the role of host genetic factors in COVID-19 severity and susceptibility can inform our understanding of the underlying biological mechanisms that influence adverse outcomes and drug development 1,2 .Here we present a second updated genome-wide association study (GWAS) on COVID-19 severity and infection susceptibility to SARS-CoV-2 from the COVID-19 Host Genetic Initiative (data release 7).We performed a meta-analysis of up to 219,692 cases and over 3 million controls, identifying 51 ...
Nature Portfolio
Erola Pairo‐Castineira, Konrad Rawlik, Andrew D. Bretherick, Ting Qi, Yang Wu, Isar Nassiri, Glenn A. McConkey, Marie Zechner, Lucija Klarić, Fiona Griffiths, Wilna Oosthuyzen, Athanasios Kousathanas, Anne Richmond, Jonathan Millar, Clark D Russell, Tomas Malinauskas, Ryan S. Thwaites, Kirstie Morrice, Seán Keating, David M. Maslove, Alistair Nichol, Malcolm G. Semple, Julian C. Knight, Manu Shankar‐Hari, Charlotte Summers, Charles Hinds, Peter Horby, Lowell Ling, Daniel F. McAuley, Hugh Montgomery, Peter Openshaw, Colin B. Begg, Timothy Walsh, Albert Tenesa, Carlos Flores, José A. Riancho, Augusto Rojas‐Martínez, Pablo Lapunzina, Sara Clohisey, Johnny Millar, Manu Shankar‐Hari, Emma Aitkin, Latha Aravindan, Ruth Armstrong, J. Kenneth Baillie, Heather Biggs, Ceilia Boz, Adam Brown, Primmy Chikowore, Richard Clark, Audrey Coutts, J. Terrence Coyle, Louise Cullum, Sukamal Das, Nicky Day, Lorna Donnelly, Esther Duncan, Paul Finernan, Max Head Fourman, Anita Furlong, James Furniss, Bernadette Gallagher, Tammy Gilchrist, Ailsa Golightly, Fiona Griffiths, Katarzyna Hafezi, Debbie Hamilton, Ross Hendry, Naomi Kearns, Dawn Law, R. M. Law, Sarah Law, Rebecca Lidstone-Scott, Christen Lauder, Louise MacGillivray, Alan Maclean, Hanning Mal, Sarah McCafferty, Ellie Mcmaster, Jen Meikle, Shona C. Moore, Sheena Murphy, Hellen Mybaya, Miranda Odam, Wilna Oosthuyzen, Chenqing Zheng, Jiantao Chen, Nick Parkinson, Trevor Paterson, Petra Tucker, Katherine Schon, Andrew Stenhouse, Mihaela Das, Maaike Swets, Helen Szoor-McElhinney, Filip Taneski, Lance Turtle, Tony Wackett, Mairi Ward, Jane Weaver, Nicola Wrobel, Marie Zechner, Jacqueline Pan, Neus Grau, Tim Jones, Rosario Lim, Martina Marotti, R. Chris Whitton, Aneta Bociek, Sara Campos, Gill Arbane, Manu Shankar‐Hari, Marlies Ostermann, Mina Cha, Fabiola DAmato, Eirini Kosifidou, Shelley Lorah, Kyma Morera, Sarah Bircham, Laura Brady, Keith Hugill, Jeremy Henning, Stephen Bonner, Evie Headlam, Jessica Jones, A. List, J Morley, Amy Welford, Bobette Kamangu, Anitha Ratnakumar, Abiola Shoremekun, Zoe Alldis, Raine Astin-Chamberlain, Fatima Bibi, Jack Biddle, Sarah Blow, Matthew L. Bolton, Catherine Borra, Ruth Bowles, Maudrian Burton, Yasmin Choudhury, Amber Cox, Amy Easthope, Patrizia Ebano, Stavros Fotiadis, Jana Gurasashvili, Rosslyn Halls, Pippa Hartridge, Delordson Kallon, Jamila Kassam, Ivone Lancoma-Malcolm, Maninderpal Matharu, P. May, Oliver Mitchelmore, Tabitha Newman, Mital Patel, Jane Pheby, Irene Pinzuti, Zoe Prime, Oleksandra Prysyazhna, Julian Shiel, Melanie Taylor, Carey Tierney, Olivier Zongo, S. M. Wood, Anne Zak, David Collier, Manuela Mundy, C. C. Thompson, Lisa Pritchard, Minnie Gellamucho, David Cartlidge, Nageswar Bandla, Lucy Bailey, Michelle Davies, Jane Delaney, Leanne Scott, Marwa Abdelrazik, Frater Alasdair, David Carter, Munzir Elhassan, Arunkumar Ganesan, Samuel Jenkins, Zoe Lamond, Dharam Purohit, Kumar Rohit, Malik Saleem, Alanna Wall, Kugan Xavier, Dhanalaksmi Bakthavatsalam, Kirolos Gehad, Pakeerathan Gnanapragasam, Kapil Jain, Swati Jain, Abdul Malik, Naveen Pappachan, Jerónimo Moreno-Cuesta, Anne Haldeos, Rachel Vincent, Maryjane Oziegb, Anna Cavazza, Maeve Cockrell, Eleanor Corcoran, Maria Depante, Clare Finney, Ellen Jerome, Abigail Knighton, Monalisa Nayak, Evita Pappa, Rohit Saha, Sian Saha, Andrew Dodd, Kevin O’Reilly, Mark McPhail, Emma Clarey, Harriet Noble, John Smith, Phoebe Coghlan, Stephen J. Brett, Anthony Gordon, Maie Templeton, David Antcliffe, Dorota Banach, Sarah Darnell, Ziortza Fernandez, Eleanor Jepson, Amal Mohammed, Roceld Rojo, Sonia Sousa Arias, Anita Gurung, Jenny Wong, Jaime Fernandez-Roman, David Hamilton, Emily Johnson, Brian Johnston, Maria Lopez Martinez, Suleman Mulla, Alicia Waite, Karen Williams, Victoria Waugh, Ingeborg Welters, Jessica Emblem, Maria Norris, David Shaw, Archana Bashyal, Sally Beer, Paula Hutton, Stuart McKechnie, Neil Davidson, Soya Mathew, Grace Readion, Jung Hee Ryu, Jean Wilson, Shruti Agrawal, Kay Elston, Megan Jones, Eoghan Meaney, Petra Polgarova, Muhammad Elbehery, Charlotte Summers, Esther Daubney, Anthony Ng, Jocelyn R. Marshall, Nazima Pathan, Katerina Stroud, Deborah White, Angela Andrew, Saima Ashraf, Amy Clark, Martin Dent, Margaret Langley, Cecilia Peters, Lucy Ryan, Julia Sampson, Shuying Wei, Alice Baddeley, Megan Meredith, Lucy Morris, Alexandra Gibbons, Lisa McLoughlin, Carlos Castro Delgado, Victoria Clark, Deborah Dawson, Lijun Ding, Georgia Durrant, Obiageri Ezeobu, Abiola Harrison, William James Hurt, Rebecca Kanu, Ashley Kinch, Susannah Leaver, Ana Lisboa, Jisha Mathew, Kamal Patel, Romina Pepermans Saluzzio, John Rawlins,
Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown
Nature Portfolio
Mari Niemi, Juha Karjalainen, Rachel G. Liao, Benjamin M. Neale, Mark J. Daly, Andrea Ganna, Gita A. Pathak, Shea J. Andrews, Masahiro Kanai, Kumar Veerapen, Israel Fernández‐Cadenas, Eva C. Schulte, Pasquale Striano, M. Marttila, Camelia C. Minică, Eirini Marouli, Mohd Anisul Karim, Frank R. Wendt, Jeanne E. Savage, Laura Sloofman, Guillaume Butler‐Laporte, Han‐Na Kim, Stavroula Kanoni, Yukinori Okada, Jinyoung Byun, Younghun Han, Mohammed Jashim Uddin, George Davey Smith, Cristen J. Willer, Joseph D. Buxbaum, Juha Mehtonen, Hilary K. Finucane, Mattia Cordioli, Alicia R. Martin, Wei Zhou, Bogdan Paşaniuc, Hanna Julienne, Hugues Aschard, Huwenbo Shi, Loïc Yengo, Renato Polimanti, Maya Ghoussaini, Jeremy Schwartzentruber, Ian Dunham, Karolina Chwiałkowska, Margherita Francescatto, Amy Trankiem, Mary K. Balaconis, Lea K. Davis, Sulggi A. Lee, James R. Priest, Alessandra Renieri, Vijay G. Sankaran, David A. van Heel, Patrick Deelen, J. Brent Richards, Tomoko Nakanishi, Les Biesecker, V. Eric Kerchberger, J. Kenneth Baillie, Francesca Mari, Anna Bernasconi, J. Kenneth Baillie, Arif Canakoglu, Brooke N. Wolford, Annika Faucon, Atanu Kumar Dutta, Claudia Schurmann, Emi N. Harry, Ewan Birney, Huy Nguyen, Jamal Nasir, Mari Kaunisto, Matthew Solomonson, Nicole Dueker, Nirmal Vadgama, Sophie Limou, Souad Rahmouni, Hamdi Mbarek, Dima Darwish, Md Mesbah Uddin, Raquel Albertos, Jordi Pèrez‐Tur, Ruolin Li, Lasse Folkersen, Ida Moltke, Nils Koelling, Alexander Teumer, Athanasios Kousathanas, Alicia Utrilla, Ricardo A. Verdugo, Ruth Zárate, Carolina Medina‐Gómez, David Gómez-Cabrero, Elena Carnero‐Montoro, Carmen L. Cadilla, Andrés Moreno‐Estrada, Adriana Garmendia, Leire Moya, Bahareh Sedaghati-khayat, Palwendé Romuald Boua, Marie-Julie Favé, Laurent C. Francioli, Audrey Lemaçon, Isabelle Migeotte, Sanjay Patel, Réka Várnai, József Szentpéteri, Csilla Sipeky, Francesca Colombo, Kathrin von Hohenstaufen, Píetro Lió, Costanza L. Vallerga, Qingbo Wang, Yosuke Tanigawa, Hogune Im, Chulho Han, Han Song, Jiwoo Lim, Y.‐A. Lee, Sugyeong Kim, Sangyoon Im, Biljana Atanasovska, Hajar Fauzan Ahmad, Cindy G. Boer, Philip R. Jansen, Lude Franke, Elżbieta Kaja, Dorota Pasko, Ingrid Kennis-Szilagyi, Sergey A. Kornilov, Vid Prijatelj, Ivana Nedeljković, Ilangkumaran Sivanadhan, Sarala Perumal, Sahar Esmaeeli, Nathaniel M. Pearson, Adam Auton, Janie F. Shelton, Anjali J. Shastri, Teresa Filshtein-Sonmez, Daniella Coker, Antony Symons, Jorge Esparza-Gordillo, Stella Aslibekyan, Jared O’Connell, Chelsea Ye, Catherine H. Weldon, Minoli A. Perera, Kevin J. O’Leary, Matthew Tuck, Travis J. O’Brien, David Meltzer, Peter H. O’Donnell, Edith A. Nutescu, Guang Yang, Cristina Alarcón, Stefanie Herrmann, Sophia Mazurek, Jeff Banagan, Zacharia Hamidi, April Barbour, Noora Raffat, Diana Moreno, Paula N. Friedman, Bart Ferwerda, Diederik van de Beek, Matthijs C. Brouwer, Alexander P. J. Vlaar, W. Joost Wiersinga, Daniëlle Posthuma, Elleke Tissink, A. H. Koos Zwinderman, Emil Uffelmann, Michiel A. van Agtmael, Anne Geke Algera, Frank van Baarle, Diane Bax, Martijn Beudel, Harm Jan Bogaard, Marije K. Bomers, Peter I. Bonta, Lieuwe D. J. Bos, Michela Botta, Justin de Brabander, Godelieve de Bree, Sanne de Bruin, Marianna Bugiani, Esther Bulle, Osoul Chouchane, Alex Cloherty, Dave A. Dongelmans, Paul Elbers, Lucas M. Fleuren, Suzanne E. Geerlings, Bart F. Geerts, Teunis B. H. Geijtenbeek, Armand R. J. Girbes, Abraham Goorhuis, Martin P. Grobusch, Florianne Hafkamp, Laura A. Hagens, Jörg Hamann, Vanessa Harris, Robert Hemke, Sabine Hermans, Leo Heunks, Markus W. Hollmann, Janneke Horn, Joppe W. Hovius, Menno D. de Jong, Rutger Koning, Niels van Mourik, Jeannine F. Nellen, Esther J. Nossent, Frederique Paulus, Edgar Peters, Tom van der Poll, Bennedikt Preckel, Jan M. Prins, Jorinde Raasveld, Tom D. Y. Reijnders, Michiel Schinkel, Marcus J. Schultz, Alex R. Schuurman, Kim Sigaloff, Marry R. Smit, Cornelis Stijnis, Willemke Stilma, Charlotte E. Teunissen, Patrick Thoral, Anissa M. Tsonas, Marc van der Valk, Denise P. Veelo, Heder de Vries, Michèle van Vugt, Dorien Wouters, René Minnaar, Adrie Kromhout, Kees W. J. van Uffelen, Ruud A. Wolterman, Genevieve Roberts, Daniel J. Park, Catherine A. Ball, Marie V. Coignet, Shannon McCurdy, Spencer C. Knight, Raghavendran Partha, Brooke Rhead, Miao Zhang, Nathan Berkowitz, Michael Gaddis, Keith Noto, Luong Ruiz, Miloš Pavlović, Eurie L. Hong, Kristin A. Rand, Ahna R. Girshick, Harendra Guturu, Asher Haug Baltzell, Souad Rahmouni, Julien Guntz, Y Beguin, Sara Pigazzini, Lindokuhle Nkambule, Youssef Bouysran, Adeline Busson, Xavier Peyrassol, Françoise Wilkin, Bruno Pichon, Guillaume Smits, Isabelle Vandernoot, Jean‐Christophe Goffard, Michel Georges, Michel Moutschen, Benoît Misset, Gilles Darcis, Julien Guiot, Laurent Jadot, Samira Azarzar, Patricia Dellot, Stéphanie Gofflot, Sabine Claassen, Axelle Bertrand, Gilles Parzibut, Mathilde Clarinval, Catherine Moermans, Olivier Malaise, Kamilia El Kandoussi, Raphaël Thonon, Pascale Huynen, Alyssia Mesdagh, Sofia Ferreira Melo, Nicolas Jacques, Emmanuel Di Valentin, François Giroule,
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-19
Nature Portfolio
Chiara Fallerini, Nicola Picchiotti, Margherita Baldassarri, Kristina Zguro, Sergio Daga, Francesca Fava, Elisa Benetti, Sara Amitrano, Mirella Bruttini, Maria Palmieri, Susanna Croci, Mirjam Lista, Giada Beligni, Floriana Valentino, Ilaria Meloni, Marco Tanfoni, Francesca Minnai, Francesca Colombo, Enrico Cabri, Maddalena Fratelli, Chiara Gabbi, Stefania Mantovani, Elisa Frullanti, Marco Gori, Francis P. Crawley, Guillaume Butler‐Laporte, Brent Richards, Hugo Zeberg, Miklós Lipcsey, Michael Hultström, Kerstin U. Ludwig, Eva C. Schulte, Erola Pairo‐Castineira, J. Kenneth Baillie, Axel Schmidt, Robert Frithiof, Simone Furini, Francesca Montagnani, Mario Tumbarello, Ilaria Rancan, Massimiliano Fabbiani, Barbara Rossetti, Laura Bergantini, Miriana d’Alessandro, Paolo Cameli, David Bennett, Federico Anedda, Simona Marcantonio, Sabino Scolletta, Federico Franchi, Maria Antonietta Mazzei, Susanna Guerrini, Edoardo Conticini, Luca Cantarini, Bruno Frediani, Danilo Tacconi, Chiara Spertilli Raffaelli, Marco Feri, Alice Donati, Raffaele Scala, Luca Guidelli, Genni Spargi, Marta Corridi, Cesira Nencioni, Leonardo Croci, Gian Piero Caldarelli, Maurizio Spagnesi, Davide Romani, Paolo Piacentini, Maria Bandini, Elena Desanctis, Silvia Cappelli, Anna Canaccini, Agnese Verzuri, Valentina Anemoli, Manola Pisani, Agostino Ognibene, Alessandro Pancrazzi, Maria Lorubbio, Massimo Vaghi, Antonella d’Arminio Monforte, Federica Gaia Miraglia, Mario U. Mondelli, Massimo Girardis, Sophie Venturelli, Stefano Busani, Andrea Cossarizza, Andrea Antinori, Alessandra Vergori, Arianna Emiliozzi, Stefano Rusconi, Matteo Siano, Arianna Gabrieli, Agostino Riva, Daniela Francisci, Elisabetta Schiaroli, Francesco Paciosi, Andrea Tommasi, Pier Giorgio Scotton, Francesca Andretta, Sandro Panese, Stefano Baratti, Renzo Scaggiante, Francesca Gatti, Saverio Giuseppe Parisi, Francesco Castelli, Eugenia Quirós-Roldán, Melania Degli Antoni, Isabella Zanella, Matteo Della Monica, Carmelo Piscopo, Mario Capasso, Roberta Russo, Immacolata Andolfo, Achille Iolascon, Giuseppe Fiorentino, Massimo Carella, Marco Castori, Filippo Aucella, Pamela Raggi, Rita Perna, Matteo Bassetti, Antonio Di Biagio, Maurizio Sanguinetti, Luca Masucci, Alessandra Guarnaccia, Serafina Valente, Oreste De Vivo, Gabriella Doddato, Rossella Tita, Annarita Giliberti, Maria Antonietta Mencarelli, Caterina Lo Rizzo, Anna Maria Pinto, Valentina Perticaroli, Francesca Ariani, Miriam Lucia Carriero, Laura Di Sarno, Diana Alaverdian, Elena Bargagli, Marco Mandalà, Alessia Giorli, Lorenzo Salerni, Patrizia Zucchi, Pierpaolo Parravicini, E. Menatti, Tullio Trotta, Ferdinando Giannattasio, Gabriella Coiro, Fabio Lena, Leonardo Gianluca Lacerenza, Domenico Coviello, Cristina Mussini, Enrico Martinelli, Sandro Mancarella, Luisa Tavecchia, Mary Ann Belli, Lia Crotti, Gianfranco Parati, Maurizio Sanarico, Francesco Raimondi, Filippo Biscarini, Alessandra Stella, Marco Rizzi, Franco Maggiolo, Diego Ripamonti, Claudia Suardi, Tiziana Bachetti, Maria Teresa La Rovere, Simona Sarzi Braga, Maurizio Bussotti, Katia Capitani, Simona Dei, Sabrina Ravaglia, Rosangela Artuso, Elena Andreucci, Giulia Gori, Angelica Pagliazzi, Erika Fiorentini, Antonio Perrella, Francesco Paolo Bianchi, Paola Bergomi, E Catena, Riccardo Colombo, Sauro Luchi, Giovanna Morelli, Paola Petrocelli, Sarah Iacopini, Sara Modica, Silvia Baroni, Francesco Vladimiro Segala, Francesco Menichetti, Marco Falcone, Giusy Tiseo, Chiara Barbieri, Tommaso Matucci, Davide Grassi, Claudio Ferri, Franco Marinangeli, Francesco Brancati, M. A. Vincenti, Valentina Borgo, Stefania Lombardi, Mirco Lenzi, Massimo Antonio Di Pietro, Francesca Vichi, Benedetta Romanin, Letizia Attala, Cecilia Costa, Andrea Gabbuti, Roberto Menè, Umberto Zuccon, Lucia Vietri, Stefano Ceri, Pietro Pinoli, Patrizia Casprini, Giuseppe Merla, Gabriella Maria Squeo, Marcello Maffezzoni, Raffaele Bruno, Marco Vecchia, Marta Colaneri, Serena Ludovisi, Yanara Marincevic-Zuniga, Jessica Nordlund, Tomas Luther, Anders Larsson, Katja Hanslin Anna Gradin, Sarah Galien, Sara Bulow Anderberg, Jacob Rosén, Sten Rubertsson, Hugo Zeberg, Robert Frithiof, Miklós Lipcsey, Michael Hultström, Sara Clohisey Peter Horby, Johnny Millar, Julian C. Knight, Hugh Montgomery, David M. Maslove, Lowell Ling, Alistair Nichol, Charlotte Summers, Timothy Walsh, Charles Hinds, Malcolm G. Semple, Peter Openshaw, Manu Shankar‐Hari, Antonia Ho, Daniel F. McAuley, Chris P. Ponting, Kathy Rowan, J. Kenneth Baillie, Fiona Griffiths, Wilna Oosthuyzen, Jen Meikle, Paul Finernan, James Furniss, Ellie Mcmaster, Andy Law, Sara Clohisey, J. Kenneth Baillie, Trevor Paterson, Tony Wackett, Ruth Armstrong, Lee Murphy, Angie Fawkes, Richard Clark, Audrey Coutts, Lorna Donnelly, Tammy Gilchrist, Katarzyna Hafezi, Louise MacGillivray, Alan Maclean, Sarah McCafferty, Kirstie Morrice, Jane Weaver, Ceilia Boz, Ailsa Golightly, M. M. Ward, Hanning Mal, Helen Szoor-McElhinney, Adam Brown, Ross Hendry, Andrew Stenhouse, Louise Cullum, Dawn Law, Sarah Law, R. M. Law, Max Head Fourman, Maaike Swets, Nicky Day, Filip Taneski, Esther Duncan, Marie Zechner,
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the presence of variants in each gene. An ensemble of LASSO logistic regression ...
Springer Science+Business Media
Rustam Al‐Shahi Salman, Catriona Keerie, Jacqueline Stephen, Steff Lewis, John Norrie, Martin Dennis, David E. Newby, Joanna M. Wardlaw, Gregory Y.H. Lip, Adrian Parry‐Jones, Phil White, Colin Baigent, Daniel Lasserson, Colin Oliver, Fiach C. O’Mahony, Shannon Amoils, John Bamford, Jane Armitage, Jonathan Emberson, Gabriel Rinkel, Gordon Lowe, Karen Innes, Kasia Adamczuk, Lynn Dinsmore, Jonathan Drever, Garry Milne, Allan Walker, Aidan Hutchison, Carol Williams, Ruth Fraser, Rosemary Anderson, Kate Covil, Kelly Stewart, Jessica Rees, Peter Hall, Alistair Bullen, Andrew Stoddart, Tom J. Moullaali, Jeb Palmer, Eleni Sakka, Joanne Perthen, Nicola Lyttle, Neshika Samarasekera, Allan MacRaild, Seona Burgess, Jessica Teasdale, Michelle Coakley, Pat Taylor, Gordon W. Blair, William Whiteley, Susan D. Shenkin, Úna Clancy, Malcolm Macleod, Rachel Sutherland, Tom J. Moullaali, Amanda Barugh, Christine Lerpiniere, Fiona Moreton, Nicholas Fethers, Tal Anjum, Manju Krishnan, Peter Slade, Sharon Storton, Marie Williams, Caroline Davies, Lynda Connor, Glyn Gainard, Carl Murphy, Mark Barber, Derek Esson, James Choulerton, Louise Shaw, Suzanne Lucas, Sarah Hierons, Joanne Avis, Andrew Stone, Lukuman Gbadamoshi, Telma Costa, Lauren Pearce, Kirsty Harkness, Emma Richards, Jo Howe, Christine Kamara, Ralf Lindert, Ali Ali, Jahanzeb Rehan, Sarah Chapman, Maria Edwards, Raj Bathula, David Cohen, Joseph E. Devine, Mushiya Mpelembue, Priya Yesupatham, Swati Chhabra, Gbadebo Adewetan, ROBERT I. W. BALLANTINE, Daniel C. Brooks, Gemma Smith, Gill Rogers, Stuart Marsden, Sarah L. Clark, Ami Wilkinson, Ellen Brown, L Stephenson, Khin Nyo, Annie Abraham, Yogish Pai, Gek Shim, Vidya Baliga, Anand R. Nair, Matthew K. Robinson, C Hawksworth, Jill Greig, Irfan Alam, Tonicha Nortcliffe, Ridha Ramiz, Ryan J. Shaw, Adrian Parry‐Jones, Stephanie J. Lee, Tracy Marsden, Jane Perez, Emily Birleson, Rajendra Yadava, Mirriam Sangombe, Sam G Stafford, Thomas A. Hughes, Lucy Knibbs, Bethan Morse, Stefan Schwarz, Benjamin Jelley, Susan White, Bella Richard, Heidi Lawson, Sally Moseley, Michelle Tayler, Mandy Edwards, Claire Triscott, Rebecca Wallace, Angela Hall, Amanda Dell, Khalid Rashed, Sarah Board, C Buckley, Alfonso Tanate, T Pitt-Kerby, Kate Beesley, Jess Perry, C Hellyer, Paul Guyler, Nisha Menon, Sharon Tysoe, Raji Prabakaran, Martin Cooper, Anoja Rajapakse, Inez Wynter, Susan Smith, Nic Weir, Cherish Boxall, Hannah Yates, Simon Smith, Pamela Crawford, Richard Marigold, Fiona E. Smith, Jake Harvey, Sue Evans, Laura Baldwin, Sarah P. Hammond, Paul N. Mudd, A. Bowring, Samantha Keenan, Kevin E. Thorpe, Mohammad Haque, Joanne Taaffe, Natalie Temple, Tracey Peachey, Kim E. Wells, Fiona Haines, Nicola Butterworth‐Cowin, Zoey Horne, Radim Líčeník, Hayley Boughton, Timothy J. England, Amanda Hedstrom, Brian Menezes, Ruth Davies, Venetia Vettimootal Johnson, Simon Whittingham-Jones, David J. Werring, Sabaa Obarey, C Watchurst, A. Ashton, Shez Feerick, Nina Francia, Azra Banaras, Daniel Epstein, Marilena Marinescu, Annick Williams, Anna M.C. Robinson, Fiona Humphries, Ijaz Anwar, Arunkumar Annamalai, Susan E. Crawford, Vicky Collins, Lorna Shepherd, Elaine Siddle, Justin Penge, Daniel Epstein, Sam Qureshi, Srinivas Murthy, Vasileios Papavasileiou, Dean Waugh, Emelda Veraque, Nathan Douglas, Numan Khan, Sankaranarayanan Ramachandran, Peter Sommerville, Anthony Rudd, Sagal Kullane, Ajay Bhalla, Jonathan Birns, Rowshanara Ahmed, Meegan Gibbons, Ewa Klamerus, Benjie Cendreda, Keith W. Muir, Nicola C. Day, Angela Welch, W. G. J. Smith, Jennifer Elliot, Salwa El Tawil, Ammad Mahmood, Kim Hatherley, Shirley Mitchell, Harjit Bains, Lauren M. Quinn, Rachel Teal, Ivie Gbinigie, George Harston, P Mathieson, Gary A. Ford, Ursula G. Schulz, James Kennedy, Kiruba Nagaratnam, Kiran Bangalore, Neelima Bhupathiraju, Chris Wharton, K. Fotherby, Nasar Ahmad, Angie Stevens, Angela Willberry, Rachel Evans, Baljinder Rai, Chloe Blake, Kamy Thavanesan, Gail Hann, Tanith Changuion, Sara Nix, Amanda Whiting, Michelle Dharmasiri, Louise Mallon, Marketa Keltos, Nigel Smyth, Charlotte Eglinton, John P. Duffy, Ela Tone, Lucy Sykes, Emily Porter, Carolyn Fitton, Nikolaos Kirkineziadis, Gillian Cluckie, Kate Kennedy, Sarah Trippier, Rebecca Williams, Elizabeth Hayter, James Rackie, Bhavini Patel, Rita Ghatala, Adrian Blight, Andrew Jones, Liqun Zhang, Lillian Choy, Anthony Pereira, Brian Clarke, Samer Al‐Hussayni, Lynn Dixon, Andrew Young, Adrian Bergin, David Broughton, Senthil Raghunathan, Benjamin Jackson, Jason P. Appleton, Gwendoline Wilkes, Amanda Buck, Carla Richardson, Judith Clarke, Lucy Fleming,
Background Oral anticoagulation reduces the rate of systemic embolism for patients with atrial fibrillation by two-thirds, but its benefits for patients with previous intracranial haemorrhage are uncertain. In the Start or STop Anticoagulants Randomised Trial (SoSTART), we aimed to establish whether starting is non-inferior to avoiding oral anticoagulation for survivors of intracranial haemorrhage who have atrial fibrillation. Methods SoSTART was a prospective, randomised, open-label, assessor-masked, ...
Elsevier BV
Athanasios Kousathanas, Erola Pairo‐Castineira, Konrad Rawlik, A. Stuckey, Christopher A. Odhams, Susan Walker, Clark D Russell, Tomas Malinauskas, Yang Wu, Jonathan Millar, Xia Shen, Katherine S. Elliott, Fiona Griffiths, Wilna Oosthuyzen, Kirstie Morrice, Seán Keating, Bo Wang, Daniel R. Rhodes, Lucija Klarić, Marie Zechner, Nick Parkinson, Afshan Siddiq, Peter Goddard, Sally Donovan, David M. Maslove, Alistair Nichol, Malcolm G. Semple, Tala Zainy, F. Maleady-Crowe, Linda Todd, Shahla Salehi, Julian C. Knight, Greg Elgar, G. C. Chan, Prabhu Arumugam, Christine Patch, Augusto Rendon, David Bentley, Clare Kingsley, Jack A. Kosmicki, Julie Horowitz, Aris Baras, Gonçalo R. Abecasis, Manuel A. R. Ferreira, Anne E. Justice, Tooraj Mirshahi, Matthew T. Oetjens, Daniel J. Rader, Marylyn D. Ritchie, Anurag Verma, Tom Fowler, Manu Shankar‐Hari, Charlotte Summers, Charles Hinds, Peter Horby, Lowell Ling, Daniel F. McAuley, Hugh Montgomery, Peter Openshaw, Paul Elliott, Timothy Walsh, Albert Tenesa, J. Kenneth Baillie, Colin B. Begg, Sara Clohisey, Charles Hinds, Peter Horby, Julian C. Knight, Lowell Ling, David M. Maslove, Daniel F. McAuley, Johnny Millar, Hugh Montgomery, Alistair Nichol, Peter Openshaw, Alexandre C. Pereira, Chris P. Ponting, Kathy Rowan, Malcolm G. Semple, Manu Shankar‐Hari, Charlotte Summers, Timothy Walsh, Latha Aravindan, Ruth Armstrong, Heather Biggs, Ceilia Boz, Adam Brown, Richard E. Clark, Audrey Coutts, J. Terrence Coyle, Louise Cullum, Sukamal Das, Nicky Day, Lorna Donnelly, Esther Duncan, Angie Fawkes, Paul Finernan, Max Head Fourman, Anita Furlong, James Furniss, Bernadette Gallagher, Tammy Gilchrist, Ailsa Golightly, Fiona Griffiths, Katarzyna Hafezi, Debbie Hamilton, Ross Hendry, Andy Law, Dawn Law, R. M. Law, Sarah Law, Rebecca Lidstone-Scott, Louise MacGillivray, Alan Maclean, Hanning Mal, Sarah McCafferty, Ellie Mcmaster, Jen Meikle, Shona C. Moore, Kirstie Morrice, Lee Murphy, Sheena Murphy, Mybaya Hellen, Wilna Oosthuyzen, Chenqing Zheng, Jiantao Chen, Nick Parkinson, Trevor Paterson, Katherine Schon, Andrew Stenhouse, Mihaela Das, Maaike Swets, Helen Szoor-McElhinney, Filip Taneski, Lance Turtle, Tony Wackett, Mairi Ward, Jane Weaver, Nicola Wrobel, Marie Zechner, Gill Arbane, Aneta Bociek, Sara Campos, Neus Grau, Tim Jones, Rosario Lim, Martina Marotti, Marlies Ostermann, Manu Shankar‐Hari, R. Chris Whitton, Zoe Alldis, Raine Astin-Chamberlain, Fatima Bibi, Jack Biddle, Sarah Blow, Matthew L. Bolton, Catherine Borra, Ruth Bowles, Maudrian Burton, Yasmin Choudhury, David Collier, Amber Cox, Amy Easthope, Patrizia Ebano, Stavros Fotiadis, Jana Gurasashvili, Rosslyn Halls, Pippa Hartridge, Delordson Kallon, Jamila Kassam, Ivone Lancoma-Malcolm, Maninderpal Matharu, P. May, Oliver Mitchelmore, Tabitha Newman, Mital Patel, Jane Pheby, Irene Pinzuti, Zoe Prime, Oleksandra Prysyazhna, Julian Shiel, Melanie Taylor, Carey Tierney, S. M. Wood, Anne Zak, Olivier Zongo, Stephen Bonner, Keith Hugill, Jessica Jones, Steven Liggett, Evie Headlam, Nageswar Bandla, Minnie Gellamucho, Michelle Davies, C. C. Thompson, Marwa Abdelrazik, Dhanalakshmi Bakthavatsalam, Munzir Elhassan, Arunkumar Ganesan, Anne Haldeos, Jerónimo Moreno-Cuesta, Dharam Purohit, Rachel Vincent, Kugan Xavier, Rohit Kumar, Alasdair Frater, Malik Saleem, Emma Carter, Samuel Jenkins, Zoe Lamond, Alanna Wall, Jaime Fernandez-Roman, David Hamilton, Emily Johnson, Brian Johnston, Maria Lopez Martinez, Suleman Mulla, David Shaw, Alicia Waite, Victoria Waugh, Ingeborg Welters, Karen Williams, Anna Cavazza, Maeve Cockrell, Eleanor Corcoran, Maria Depante, Clare Finney, Ellen Jerome, Mark McPhail, Monalisa Nayak, Harriet Noble, Kevin O’Reilly, Evita Pappa, Rohit Saha, Sian Saha, John Smith, Abigail Knighton, David Antcliffe, Dorota Banach, Stephen J. Brett, Phoebe Coghlan, Ziortza Fernandez, Anthony Gordon, Roceld Rojo, Sonia Sousa Arias, Maie Templeton, Megan Meredith, Lucy Morris, Lucy Ryan, Amy Clark, Julia Sampson, Cecilia Peters, Martin Dent, Margaret Langley, Saima Ashraf, Shuying Wei, Angela Andrew, Archana Bashyal, Neil Davidson, Paula Hutton, Stuart McKechnie, Jean Wilson, David Baptista, Rebecca Crowe, Rita Fernandes, Rosaleen Herdman-Grant, Anna Joseph, Denise O’Connor, Meryem Allen, Adam Loveridge, India McKenley, Eriko Morino, Andrés Naranjo, Richard Simms, Kathryn Sollesta, Andrew Swain, Harish Venkatesh, Jacyntha Khera, Jonathan Fox, Gillian Andrew, J. Kenneth Baillie, Lucy Barclay, Marie Callaghan, Rachael Campbell, Sarah J. Clark, Dave Hope, Lucy Marshall, Corrienne McCulloch, Kate Briton, Jo Singleton, Sophie Birch, Lutece Brimfield, Zoe Daly, David Pogson, Steve Rose, Angela Nown,
Abstract Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care 1 or hospitalization 2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals ...
Nature Portfolio
Guido Rubboli, Christoph P. Beier, Kaja Kristine Selmer, Marte Syvertsen, Amy Shakeshaft, Amber Collingwood, Anna Hall, Danielle M. Andrade, Choong Yi Fong, Joanna Gesche, David A. Greenberg, Khalid Hamandi, Kheng Seang Lim, Ching Ching Ng, Alessandro Orsini, Lisa J. Strug, Naim Panjwani, Fan Lin, Danielle M. Andrade, Jana Zárubová, Zuzana Šobíšková, Cechovaz, Pracoviste, Michaela Kajšová, Guido Rubboli, Rikke S. Møller, Elena Gardella, Christoph P. Beier, Joanna Gesche, M Miranda, Inga Talvik, Pasquale Striano, Alessandro Orsini, Choong Yi Fong, Ching Ching Ng, Kheng Seang Lim, Kaja Kristine Selmer, Marte Syvertsen, Pronab Bala, Amy Kitching, Kate Irwin, Lorna Walding, Lynsey Adams, Uma Jegathasan, Rachel Swingler, Rachel Wane, Julia Aram, Nikil Sudarsan, Dee Mullan, Rebecca Ramsay, Vivien Richmond, M. Sargent, Paul Frattaroli, Matthew D. Taylor, Marie Home, Sal Uka, Susan Kilroy, Tonicha Nortcliffe, Kheng Seang Lim, Kelly Holroyd, Khalid Hamandi, Alison McQueen, Dympna Mcaleer, Dina Jayachandran, Dawn Egginton, Bridget MacDonald, Michael Chang, David Deekollu, Alok Gaurav, Caroline Hamilton, Jaya Natarajan Inyan Takon, Janet Cotta, Nick Moran, Jeremy D.P. Bland, Rosemary Belderbos, Heather Collier, Joanne Henry, Matthew J. Milner, Sam White, Michalis Koutroumanidis, William Stern, Mark P. Richardson, Jennifer M. Quirk, Javier Peña‐Ceballos, Anastasia, Papathanasiou, Ioannis Stavropoulos, Dora A. Lozsádi, Andrew Swain, Charlotte Quamina, Jennifer Crooks, Tahir Majeed, Sonia Raj, Shakeelah Patel, Michael C. Young, Melissa Maguire, Munni Ray, Caroline Peacey, Linetty Makawa, Asyah Chhibda, Eve Sacre, Shanaz Begum, Martin O’Malley, Lap Yeung, Claire Holliday, Louise Woodhead, Karen Helton Rhodes, Rhys H. Thomas, Shan Ellawela, Joanne Glenton, Verity Calder, John M. Davis, Paul McAlinden, Sarah Francis, Lisa Robson, Karen Lanyon, Graham A. Mackay, Elma Stephen, Coleen Thow, Margaret Connon, Martin Kirkpatrick, Susan MacFarlane, Anne Scott MacLeod, Debbie Rice, Siva Kumar, Carolyn Campbell, Vicky Collins, William Whitehouse, Christina Giavasi, Boyanka Petrova, Thomas D. Brown, Catie Picton, Michael O’Donoghue, Charlotte West, Helen Navarra, Sean Slaght, Catherine Edwards, Andrew Gribbin, Liz Nelson, Stephen Warriner, Heather Angus‐Leppan, Loveth Ehiorobo, Bintou Camara, T Samakomva, Rajiv Mohanraj, Victoria A. Parker, Rajesh K. Pandey, Lisa Charles, Catherine Cotter, Archana Desurkar, Alison Hyde, Rachel Harrison, Markus Reuber, R. T. Clegg, J Sidebottom, Mayeth Recto, Patrick Easton, Charlotte Waite, Alice Howell, Jacqueline Smith, R. T. Clegg, Shyam Mariguddi, Zena Haslam, Elizabeth Caruana Galizia, Hannah R. Cock, Mark Mencias, Samantha Truscott, Déirdre Daly, Hilda Mhandu, Nooria Said, Mark I. Rees, Seo‐Kyung Chung, William Owen Pickrell, Beata Fonferko‐Shadrach, Mark D. Baker, Amy B. Heagle, Louise Swain, Kirsty O’Brien, Fraser Scott, Naveed Ghaus, Gail Castle, Jacqui Bartholomew, Ann Needle, Julie Ball, Andrea Clough, Shashikiran Sastry, Charlotte Busby Amit Agrawal, Debbie Dickerson, Almu Duran, Muhammad Shamim Khan, Laura Thrasyvoulou, Eve Irvine, Sarah Tittensor, Jacqueline Daglish, Sumant Kumar, Claire Backhouse, Claire Mewies, Julia Aram, Nikil Sudarsan, Dee Mullan, Rebecca Ramsay, Vivien Richmond, Denise Skinner, M. Sargent, Rahul Bharat, Sarah-Jane Sharman, Arun Saraswatula, Helen Cockerill, David A. Greenberg, Pasquale Striano, Rhys H. Thomas, Jana Zarubova, Mark P. Richardson, Lisa J. Strug, Deb K. Pal,
Abstract Reliable definitions, classifications and prognostic models are the cornerstones of stratified medicine, but none of the current classifications systems in epilepsy address prognostic or outcome issues. Although heterogeneity is widely acknowledged within epilepsy syndromes, the significance of variation in electroclinical features, comorbidities and treatment response, as they relate to diagnostic and prognostic purposes, has not been explored. In this paper, we aim to provide an evidence- ...
Tópico(s): Genetics and Neurodevelopmental Disorders
2023 - Oxford University Press | Brain Communications
Erola Pairo‐Castineira, Konrad Rawlik, Andrew D. Bretherick, Ting Qi, Yang Wu, Isar Nassiri, Glenn A. McConkey, Marie Zechner, Lucija Klarić, Fiona Griffiths, Wilna Oosthuyzen, Athanasios Kousathanas, Anne Richmond, Jonathan Millar, Clark D Russell, Tomas Malinauskas, Ryan S. Thwaites, Kirstie Morrice, Seán Keating, David M. Maslove, Alistair Nichol, Malcolm G. Semple, Julian C. Knight, Manu Shankar‐Hari, Charlotte Summers, Charles Hinds, Peter Horby, Lowell Ling, Daniel F. McAuley, Hugh Montgomery, Peter Openshaw, Colin B. Begg, Timothy Walsh, Albert Tenesa, Carlos Flores, José A. Riancho, Augusto Rojas‐Martínez, Pablo Lapunzina, Sara Clohisey, Johnny Millar, Manu Shankar‐Hari, Emma Aitkin, Latha Aravindan, Ruth Armstrong, J. Kenneth Baillie, Heather Biggs, Ceilia Boz, Adam Brown, Primmy Chikowore, Richard Clark, Audrey Coutts, J. Terrence Coyle, Louise Cullum, Sukamal Das, Nicky Day, Lorna Donnelly, Esther Duncan, Paul Finernan, Max Head Fourman, Anita Furlong, James Furniss, Bernadette Gallagher, Tammy Gilchrist, Ailsa Golightly, Fiona Griffiths, Katarzyna Hafezi, Debbie Hamilton, Ross Hendry, Naomi Kearns, Dawn Law, R. M. Law, Sarah Law, Rebecca Lidstone-Scott, Christen Lauder, Louise MacGillivray, Alan Maclean, Hanning Mal, Sarah McCafferty, Ellie Mcmaster, Jen Meikle, Shona C. Moore, Sheena Murphy, Hellen Mybaya, Miranda Odam, Wilna Oosthuyzen, Chenqing Zheng, Jiantao Chen, Nick Parkinson, Trevor Paterson, Petra Tucker, Katherine Schon, Andrew Stenhouse, Mihaela Das, Maaike Swets, Helen Szoor-McElhinney, Filip Taneski, Lance Turtle, Tony Wackett, Mairi Ward, Jane Weaver, Nicola Wrobel, Marie Zechner, Jacqueline Pan, Neus Grau, Tim Jones, Rosario Lim, Martina Marotti, R. Chris Whitton, Aneta Bociek, Sara Campos, Gill Arbane, Manu Shankar‐Hari, Marlies Ostermann, Mina Cha, Fabiola DAmato, Eirini Kosifidou, Shelley Lorah, Kyma Morera, Sarah Bircham, Laura Brady, Keith Hugill, Jeremy Henning, Stephen Bonner, Evie Headlam, Jessica Jones, A. List, J Morley, Amy Welford, Bobette Kamangu, Anitha Ratnakumar, Abiola Shoremekun, Zoe Alldis, Raine Astin-Chamberlain, Fatima Bibi, Jack Biddle, Sarah Blow, Matthew L. Bolton, Catherine Borra, Ruth Bowles, Maudrian Burton, Yasmin Choudhury, Amber Cox, Amy Easthope, Patrizia Ebano, Stavros Fotiadis, Jana Gurasashvili, Rosslyn Halls, Pippa Hartridge, Delordson Kallon, Jamila Kassam, Ivone Lancoma-Malcolm, Maninderpal Matharu, P. May, Oliver Mitchelmore, Tabitha Newman, Mital Patel, Jane Pheby, Irene Pinzuti, Zoe Prime, Oleksandra Prysyazhna, Julian Shiel, Melanie Taylor, Carey Tierney, Olivier Zongo, S. M. Wood, Anne Zak, David Collier, Manuela Mundy, C. C. Thompson, Lisa Pritchard, Minnie Gellamucho, David Cartlidge, Nageswar Bandla, Lucy Bailey, Michelle Davies, Jane Delaney, Leanne Scott, Marwa Abdelrazik, Frater Alasdair, David Carter, Munzir Elhassan, Arunkumar Ganesan, Samuel Jenkins, Zoe Lamond, Dharam Purohit, Kumar Rohit, Malik Saleem, Alanna Wall, Kugan Xavier, Dhanalaksmi Bakthavatsalam, Kirolos Gehad, Pakeerathan Gnanapragasam, Kapil Jain, Swati Jain, Abdul Malik, Naveen Pappachan, Jerónimo Moreno-Cuesta, Anne Haldeos, Rachel Vincent, Maryjane Oziegb, Anna Cavazza, Maeve Cockrell, Eleanor Corcoran, Maria Depante, Clare Finney, Ellen Jerome, Abigail Knighton, Monalisa Nayak, Evita Pappa, Rohit Saha, Sian Saha, Andrew Dodd, Kevin O’Reilly, Mark McPhail, Emma Clarey, Harriet Noble, John Smith, Phoebe Coghlan, Stephen J. Brett, Anthony Gordon, Maie Templeton, David Antcliffe, Dorota Banach, Sarah Darnell, Ziortza Fernandez, Eleanor Jepson, Amal Mohammed, Roceld Rojo, Sonia Sousa Arias, Anita Gurung, Jenny Wong, Jaime Fernandez-Roman, David Hamilton, Emily Johnson, Brian Johnston, Maria Lopez Martinez, Suleman Mulla, Alicia Waite, Karen Williams, Victoria Waugh, Ingeborg Welters, Jessica Emblem, Maria Norris, David Shaw, Archana Bashyal, Sally Beer, Paula Hutton, Stuart McKechnie, Neil Davidson, Soya Mathew, Grace Readion, Jung Hee Ryu, Jean Amos Wilson, Shruti Agrawal, Kay Elston, Megan Jones, Eoghan Meaney, Petra Polgarova, Muhammad Elbehery, Charlotte Summers, Esther Daubney, Anthony Ng, Jocelyn R. Marshall, Nazima Pathan, Katerina Stroud, Deborah L. White, Angela Andrew, Saima Ashraf, Amy Clark, Martin Dent, Margaret Langley, Cecilia Peters, Lucy Ryan, Julia Sampson, Shuying Wei, Alice Baddeley, Megan Meredith, Lucy Morris, Alexandra Gibbons, Lisa McLoughlin, Carlos Castro Delgado, Victoria Clark, Deborah Dawson, Lijun Ding, Georgia Durrant, Obiageri Ezeobu, Abiola Harrison, William James Hurt, Rebecca Kanu, Ashley Kinch, Susannah Leaver, Ana Lisboa, Jisha Mathew, Kamal Patel, Romina Pepermans Saluzzio, John Rawlins,
Nature Portfolio
Delnaz Roshandel, Eric J. Sanders, Amy Shakeshaft, Naim Panjwani, Lin Fan, Amber Collingwood, Anna Hall, Katherine Keenan, Celine Deneubourg, Filippo Mirabella, Simon Topp, Jana Zarubova, Rhys H. Thomas, Inga Talvik, Marte Syvertsen, Pasquale Striano, Anna Smith, Kaja Kristine Selmer, Guido Rubboli, Alessandro Orsini, Ching Ching Ng, Rikke S. Møller, Kheng Seang Lim, Khalid Hamandi, David A. Greenberg, Joanna Gesche, Elena Gardella, Choong Yi Fong, Christoph P. Beier, Danielle M. Andrade, Heinz Jungbluth, Mark P. Richardson, Annalisa Pastore, Manolis Fanto, Deb K. Pal, Lisa J. Strug, Zuzana Šobíšková, Cechovaz Pracoviste, Michaela Kajšová, Rikke S. Møller, Elena Gardella, M Miranda, Pasquale Striano, Alessandro Orsini, Pronab Bala, Amy Kitching, Kate Irwin, Lorna Walding, Lynsey Adams, Uma Jegathasan, Rachel Swingler, Rachel Wane, Julia Aram, Nikil Sudarsan, Dee Mullan, Rebecca Ramsay, Vivien Richmond, M. Sargent, Paul Frattaroli, Matthew D. Taylor, Marie Home, Sal Uka, Susan Kilroy, Tonicha Nortcliffe, Kheng Seang Lim, Kelly Holroyd, Alison McQueen, Dympna Mcaleer, Dina Jayachandran, Dawn Egginton, Bridget MacDonald, Michael Chang, David Deekollu, Alok Gaurav, Caroline Hamilton, Jaya Natarajan, Inyan Takon, Janet Cotta, Nick Moran, Jeremy D.P. Bland, Rosemary Belderbos, Heather Collier, Joanne Henry, Matthew J. Milner, Sam White, Michalis Koutroumanidis, William Stern, Jennifer M. Quirk, Javier Peña‐Ceballos, Anastasia Papathanasiou, Ioannis Stavropoulos, Dora A. Lozsádi, Andrew Swain, Charlotte Quamina, Jennifer Crooks, Tahir Majeed, Sonia Raj, Shakeelah Patel, Michael C. Young, Melissa Maguire, Munni Ray, Caroline Peacey, Linetty Makawa, Asyah Chhibda, Eve Sacre, Shanaz Begum, Martin O’ Malley, Lap Yeung, Claire Holliday, Louise Woodhead, Karen Helton Rhodes, Shan Ellawela, Joanne Glenton, Verity Calder, John M. Davis, Paul McAlinden, Sarah Francis, Lisa Robson, Karen Lanyon, Graham A. Mackay, Elma Stephen, Coleen Thow, Margaret Connon, Martin Kirkpatrick, Susan MacFarlane, Anne Scott MacLeod, Debbie Rice, Siva Kumar, Carolyn Campbell, Vicky Collins, William Whitehouse, Christina Giavasi, Boyanka Petrova, Thomas D. Brown, Catie Picton, Michael O’Donoghue, Charlotte West, Helen Navarra, Sean Slaght, Catherine Edwards, Andrew Gribbin, Liz Nelson, Stephen Warriner, Heather Angus‐Leppan, Loveth Ehiorobo, Bintou Camara, T Samakomva, Rajiv Mohanraj, Victoria A. Parker, Rajesh K. Pandey, Lisa Charles, Catherine Cotter, Archana Desurkar, Alison Hyde, Rachel Harrison, Markus Reuber, R. T. Clegg, J Sidebottom, Mayeth Recto, Patrick Easton, Charlotte Waite, Alice Howell, Jacqueline Smith, Shyam Mariguddi, Zena Haslam, Elizabeth Caruana Galizia, Hannah R. Cock, Mark Mencias, Samantha Truscott, Déirdre Daly, Hilda Mhandu, Nooria Said, Mark I. Rees, Seo‐Kyung Chung, William Owen Pickrell, Beata Fonferko‐Shadrach, Mark D. Baker, Fraser Scott, Naveed Ghaus, Gail Castle, Jacqui Bartholomew, Ann Needle, Julie Ball, Andrea Clough, Shashikiran Sastry, Charlotte Busby, Amit Agrawal, Debbie Dickerson, Almu Duran, Muhammad Shamim Khan, Laura Thrasyvoulou, Eve Irvine, Sarah Tittensor, Jacqueline Daglish, Sumant Kumar, Claire Backhouse, Claire Mewies, Julia Aram, Nikil Sudarsan, Dee Mullan, Rebecca Ramsay, Vivien Richmond, Denise Skinner, M. Sargent, Rahul Bharat, Sarah-Jane Sharman, Arun Saraswatula, Helen Cockerill,
Abstract Elevated impulsivity is a key component of attention-deficit hyperactivity disorder (ADHD), bipolar disorder and juvenile myoclonic epilepsy (JME). We performed a genome-wide association, colocalization, polygenic risk score, and pathway analysis of impulsivity in JME ( n = 381). Results were followed up with functional characterisation using a drosophila model. We identified genome-wide associated SNPs at 8q13.3 ( P = 7.5 × 10 −9 ) and 10p11.21 ( P = 3.6 × 10 −8 ). The 8q13.3 locus colocalizes with SLCO5A1 expression ...
Tópico(s): Ion Transport and Channel Regulation
2023 - Nature Portfolio | npj Genomic Medicine
Amy Shakeshaft, Petroula Laiou, Eugenio Abela, Ioannis Stavropoulos, Mark P. Richardson, Deb K. Pal, Alessandro Orsini, Alice Howell, Alison Hyde, Alison McQueen, Almu Duran, Alok Gaurav, Amber Collingwood, Amy Kitching, Amy Shakeshaft, Anastasia Papathanasiou, Andrea Clough, Andrew Gribbin, Andrew Swain, Ann Needle, Anna Hall, Anna Smith, Anne Scott MacLeod, Asyah Chhibda, Beata Fonferko‐Shadrach, Bintou Camara, Boyanka Petrova, Carmel Stuart, Caroline Hamilton, Caroline Peacey, Carolyn Campbell, Catherine Cotter, Catherine Edwards, Catie Picton, Charlotte Busby, Charlotte Quamina, Charlotte Waite, Charlotte West, Ching Ching Ng, Christina Giavasi, Claire Backhouse, Claire Holliday, Claire Mewies, Coleen Thow, Dawn Egginton, Debbie Dickerson, Debbie Rice, Dee Mullan, Déirdre Daly, Dympna Mcaleer, Elena Gardella, Elma Stephen, Eve Irvine, Eve Sacre, Fan Lin, Gail Castle, Graham A. Mackay, Kheng Seang Lim, Hannah R. Cock, Heather Collier, Helen Cockerill, Helen Navarra, Hilda Mhandu, Holly Crudgington, Imogen Hayes, Ioannis Stavropoulos, Jacqueline Daglish, Jacqueline Smith, Jacqui Bartholomew, Janet Cotta, Javier Peña‐Ceballos, Jaya Natarajan, Jennifer Crooks, Jennifer M. Quirk, Jeremy D.P. Bland, J Sidebottom, Joanna Gesche, Joanne Glenton, Joanne Henry, John M. Davis, Julie Ball, Kaja Kristine Selmer, Karen Helton Rhodes, Kelly Holroyd, Kheng Seang Lim, Kirsty O’Brien, Laura Thrasyvoulou, Linetty Makawa, Lisa Charles, Mark P. Richardson, Liz Nelson, Lorna Walding, Louise Woodhead, Loveth Ehiorobo, Lynn D. Hawkins, Lynsey Adams, Margaret Connon, Marie Home, Mark D. Baker, Mark Mencias, Mark P. Richardson, M. Sargent, Marte Syvertsen, Matthew J. Milner, Mayeth Recto, Michael Chang, Michael O’Donoghue, Michael C. Young, Munni Ray, Naim Panjwani, Naveed Ghaus, Nikil Sudarsan, Nooria Said, William Owen Pickrell, Patrick Easton, Paul Frattaroli, Paul McAlinden, Rachel Harrison, Rachel Swingler, Rachel Wane, Rebecca Ramsay, Rikke S. Møller, R. J. S. McDowall, R. T. Clegg, Sal Uka, Sam White, Samantha Truscott, Sarah Francis, Sarah Tittensor, Sarah-Jane Sharman, Seo‐Kyung Chung, Shakeelah Patel, Shan Ellawela, Shanaz Begum, Sharon Kempson, Sonia Raj, Sophie Bayley, Stephen Warriner, Susan Kilroy, Susan MacFarlane, Thomas D. Brown, T Samakomva, Tonicha Nortcliffe, Verity Calder, Vicky Collins, Victoria A. Parker, Vivien Richmond, William Stern, Zena Haslam, Zuzana Šobíšková, Amit Agrawal, Amy B. Heagle, Andrea D. Praticò, Archana Desurkar, Arun Saraswatula, Bridget MacDonald, Choong Yi Fong, Christoph P. Beier, Danielle M. Andrade, Darwin Pauldhas, David A. Greenberg, David Deekollu, Deb K. Pal, Dina Jayachandran, Dora A. Lozsádi, Elizabeth Caruana Galizia, Fraser Scott, Guido Rubboli, Heather Angus‐Leppan, Inga Talvik, Inyan Takon, Jana Zárubová, Jeanette Koht, Julia Aram, Karen Lanyon, Kate Irwin, Khalid Hamandi, Lap Yeung, Lisa J. Strug, Mark I. Rees, Markus Reuber, Martin Kirkpatrick, Matthew D. Taylor, Melissa Maguire, Michalis Koutroumanidis, Muhammad Shamim Khan, Nick Moran, Pasquale Striano, Pronab Bala, Rahul Bharat, Rajesh K. Pandey, Rajiv Mohanraj, Rhys H. Thomas, Rosemary Belderbos, Sean Slaght, Shane Delamont, Shashikiran Sastry, Shyam Mariguddi, Siva Kumar, Sumant Kumar, Tahir Majeed, Uma Jegathasan, William Whitehouse,
Abnormal EEG features are a hallmark of epilepsy, and abnormal frequency and network features are apparent in EEGs from people with idiopathic generalized epilepsy in both ictal and interictal states. Here, we characterize differences in the resting-state EEG of individuals with juvenile myoclonic epilepsy and assess factors influencing the heterogeneity of EEG features. We collected EEG data from 147 participants with juvenile myoclonic epilepsy through the Biology of Juvenile Myoclonic Epilepsy ...
Tópico(s): Functional Brain Connectivity Studies
2022 - Oxford University Press | Brain Communications
Jannik Boos, Caspar I. van der Made, Gayatri Ramakrishnan, Eamon Coughlan, Rosanna Asselta, Britt-Sabina Löscher, Luca Valenti, Rafael de Cid, Luis Bujanda, Antonio Julià, Erola Pairo-Castineira, J. Kenneth Baillie, Sandra May, Berina Zametica, Julia Heggemann, Agustı́n Albillos, Jesus M. Banales, Jordi Barretina, Natalia Blay, Paolo Bonfanti, Maria Buti, Javier Fernandez, Sara Marsal, Daniele Prati, Luisa Ronzoni, Nicoletta Sacchi, Valeria Rimoldi, Elvezia Maria Paraboschi, Alessandra Bandera, Flora Peyvandi, Giacomo Grasselli, Francesco Blasi, Francesco Malvestiti, Serena Pelusi, Cristiana Bianco, Lorenzo Miano, Angela Lombardi, Pietro Invernizzi, Alessio Gerussi, Giuseppe Citerio, Andrea Biondi, Maria Grazia Valsecchi, Marina Elena Cazzaniga, Giuseppe Foti, Ilaria Beretta, Mariella D’Angiò, Laura Rachele Bettini, Xavier Farré, Susana Iraola‐Guzmán, Manolis Kogevinas, Gemma Castaño‐Vinyals, Koldo García‐Etxebarria, Beatriz Nafría Jiménez, Mauro DʼAmato, Adriana Palom, Colin B. Begg, Sara Clohisey, Charles Hinds, Peter Horby, Julian C. Knight, Lowell Ling, David M. Maslove, Daniel F. McAuley, Johnny Millar, Hugh Montgomery, Alistair Nichol, Peter Openshaw, Alexandre C. Pereira, Chris P. Ponting, Kathy Rowan, Malcolm G. Semple, Manu Shankar‐Hari, Charlotte Summers, Timothy Walsh, J. Kenneth Baillie, Latha Aravindan, Ruth Armstrong, Heather Biggs, Ceilia Boz, Adam Brown, Richard E. Clark, Sara Clohisey, Audrey Coutts, J. Terrence Coyle, Louise Cullum, Sukamal Das, Nicky Day, Lorna Donnelly, Esther Duncan, Angie Fawkes, Paul Fineran, Max Head Fourman, Anita Furlong, James Furniss, Bernadette Gallagher, Tammy Gilchrist, Ailsa Golightly, Fiona Griffiths, Katarzyna Hafezi, Debbie Hamilton, Ross Hendry, Andy Law, Dawn Law, R. M. Law, Sarah Law, Rebecca Lidstone-Scott, Louise MacGillivray, Alan Maclean, Hanning Mal, Sarah McCafferty, Ellie Mcmaster, Jen Meikle, Shona C. Moore, Kirstie Morrice, Lee Murphy, Sheena Murphy, Mybaya Hellen, Wilna Oosthuyzen, Chenqing Zheng, Jiantao Chen, Nick Parkinson, Trevor Paterson, Katherine Schon, Andrew Stenhouse, Mihaela Das, Maaike Swets, Helen Szoor-McElhinney, Filip Taneski, Lance Turtle, Tony Wackett, Mairi Ward, Jane Weaver, Nicola Wrobel, Marie Zechner, Mybaya Hellen, Gill Arbane, Aneta Bociek, Sara Campos, Neus Grau, Tim Jones, Rosario Lim, Martina Marotti, Marlies Ostermann, Manu Shankar‐Hari, R. Chris Whitton, Zoe Alldis, Raine Astin-Chamberlain, Fatima Bibi, Jack Biddle, Sarah Blow, Matthew L. Bolton, Catherine Borra, Ruth Bowles, Maudrian Burton, Yasmin Choudhury, David Collier, Amber Cox, Amy Easthope, Patrizia Ebano, Stavros Fotiadis, Jana Gurasashvili, Rosslyn Halls, Pippa Hartridge, Delordson Kallon, Jamila Kassam, Ivone Lancoma-Malcolm, Maninderpal Matharu, P. May, Oliver Mitchelmore, Tabitha Newman, Mital Patel, Jane Pheby, Irene Pinzuti, Zoe Prime, Oleksandra Prysyazhna, Julian Shiel, Melanie Taylor, Carey Tierney, S. M. Wood, Anne Zak, Olivier Zongo, Stephen Bonner, Keith Hugill, Jessica Jones, Steven Liggett, Evie Headlam, Nageswar Bandla, Minnie Gellamucho, Michelle Davies, C. C. Thompson, Marwa Abdelrazik, Dhanalakshmi Bakthavatsalam, Munzir Elhassan, Arunkumar Ganesan, Anne Haldeos, Jerónimo Moreno-Cuesta, Dharam Purohit, Rachel Vincent, Kugan Xavier, Kumar Rohit, Frater Alasdair, Malik Saleem, Carter David, Jenkins Samuel, Zoe Lamond, Wall Alanna, Jaime Fernandez-Roman, David Hamilton, Emily Johnson, Brian Johnston, Maria Lopez Martinez, Suleman Mulla, David Shaw, Alicia Waite, Victoria Waugh, Ingeborg Welters, Karen Williams, Anna Cavazza, Maeve Cockrell, Eleanor Corcoran, Maria Depante, Clare Finney, Ellen Jerome, Mark McPhail, Monalisa Nayak, Harriet Noble, Kevin O’Reilly, Evita Pappa, Rohit Saha, Sian Saha, John Smith, Abigail Knighton, David Antcliffe, Dorota Banach, Stephen J. Brett, Phoebe Coghlan, Ziortza Fernandez, Anthony Gordon, Roceld Rojo, Sonia Sousa Arias, Maie Templeton, Megan Meredith, Lucy Morris, Lucy Ryan, Amy Clark, Julia Sampson, Cecilia Peters, Martin Dent, Margaret Langley, Saima Ashraf, Shuying Wei, Angela Andrew, Archana Bashyal, Neil Davidson, Paula Hutton, Stuart McKechnie, Jean Wilson, David Baptista, Rebecca Crowe, Rita Fernandes, Rosaleen Herdman-Grant, Anna Joseph, Denise O’Connor, Meryem Allen, Adam Loveridge, India McKenley, Eriko Morino, Andrés Naranjo, Richard Simms, Kathryn Sollesta, Andrew Swain, Harish Venkatesh, Jacyntha Khera, Jonathan Fox, Gillian Andrew, J. Kenneth Baillie, Lucy Barclay, Marie Callaghan, Rachael Campbell, Sarah Clark, Dave Hope, Lucy Marshall, Corrienne McCulloch, Kate Briton, Jo Singleton, Sohphie Birch, Lutece Brimfield, Zoe Daly, David Pogson, Steve Rose, Ceri Battle, Elaine Brinkworth, Rachel Harford, Carl Murphy, Luke Newey, Tabitha Rees,
Despite extensive global research into genetic predisposition for severe COVID-19, knowledge on the role of rare host genetic variants and their relation to other risk factors remains limited. Here, 52 genes with prior etiological evidence were sequenced in 1,772 severe COVID-19 cases and 5,347 population-based controls from Spain/Italy. Rare deleterious TLR7 variants were present in 2.4% of young (<60 years) cases with no reported clinical risk factors (n = 378), compared to 0.24% of controls (odds ratio [ ...
Elsevier BV
Tonicha Crook, Jay Morgan, Arno Pauly, Markus Roggenbach,
In Computer Science there is a strong consensus that it is highly desirable to combine the versatility of Machine Learning (ML) with the assurances formal verification can provide. However, it is unclear what such ‘verified ML’ should look like. This paper is the first to formalise the concepts of classifiers and learners in ML in terms of computable analysis. It provides results about which properties of classifiers and learners are computable. By doing this we establish a bridge between the continuous ...
Tópico(s): Advanced Malware Detection Techniques
2023 - Springer Science+Business Media | Lecture notes in computer science
Abstract Studies of Ibn Faḍlān’s tenth-century Risāla , a travel account detailing his journey from Baghdad to the banks of the Volga River, typically rely on thirteenth-century witnesses to the original travelogue. These are our earliest and fullest versions of the text, but are not the only extant records of Ibn Faḍlān’s journey. Due to both its late dating and its spurious interpolations, the partial preservation of the Risāla in Amīn Rāzī’s sixteenth-century geographical work, Haft Iqlīm , is frequently ...
Tópico(s): Archaeology and Historical Studies
2022 - Brill | Medieval Encounters