Nariaki Asada, Masayuki Takase, Jin Nakamura, Akiko Oguchi, Misako Asada, Norio Suzuki, Ken–ichi Yamamura, Narihito Nagoshi, Shinsuke Shibata, Tata Nageswara Rao, Hans Jörg Fehling, Atsushi Fukatsu, Naoko Minegishi, Toru Kita, Takeshi Kimura, Hideyuki Okano, Masayuki Yamamoto, Motoko Yanagita,
In chronic kidney disease, fibroblast dysfunction causes renal fibrosis and renal anemia. Renal fibrosis is mediated by the accumulation of myofibroblasts, whereas renal anemia is mediated by the reduced production of fibroblast-derived erythropoietin, a hormone that stimulates erythropoiesis. Despite their importance in chronic kidney disease, the origin and regulatory mechanism of fibroblasts remain unclear. Here, we have demonstrated that the majority of erythropoietin-producing fibroblasts in ...
Tópico(s): Tissue Engineering and Regenerative Medicine
2011 - American Society for Clinical Investigation | Journal of Clinical Investigation
Yasuhiro Shimane, Yuji Hatada, Hiroaki Minegishi, Toru Mizuki, Akinobu Echigo, Masayuki Miyazaki, Yukari Ohta, Ron Usami, William D. Grant, Koki Horikoshi,
Strain YSM-123 T was isolated from commercial salt made from Japanese seawater in Niigata prefecture. Optimal NaCl and Mg 2+ concentrations for growth were 4.0–4.5 M and 5 mM, respectively. The isolate was a mesophilic and slightly alkaliphilic haloarchaeon, whose optimal growth temperature and pH were 37 °C and pH 8.0–9.0. Phylogenetic analysis based on 16S rRNA gene sequence analysis suggested that strain YSM-123 T is a member of the phylogenetic group defined by the family Halobacteriaceae , but ...
Tópico(s): Diatoms and Algae Research
2009 - Microbiology Society | INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
Akinobu Echigo, Hiroaki Minegishi, Toru Mizuki, Masahiro Kamekura, Ron Usami,
Two moderately halophilic and alkaliphilic bacteria, designated strains BH1(T) and HN5, were isolated from forest soil and garden soil, respectively, in Japan. Cells of strains BH1(T) and HN5 were non-motile, aerobic, bean-shaped, formed irregular clusters with 2-20 cells, Gram-positive and contained A1gamma, meso-diaminopimelic acid-type murein. Spore formation was not detected. Growth occurred in 5-25 % (w/v) NaCl (optimum, 10-15 %, w/v), at pH 6.0-10.0 (optimum, pH 8.5-9.0) and at 20-40 degrees C (optimum, ...
Tópico(s): Microbial Metabolic Engineering and Bioproduction
2009 - Microbiology Society | INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
Hiroaki Minegishi, Toru Mizuki, Akinobu Echigo, Tadamasa Fukushima, Masahiro Kamekura, Ron Usami,
Haloarchaeal strains require high concentrations of NaCl for their growth, with optimum concentrations of 10–30%. They display a wide variety of morphology and physiology including pH range for growth. Many strains grow at neutral to slightly alkaline pH, and some only at alkaline pH. However, no strain has been reported to grow only in acidic pH conditions within the family Halobacteriaceae. In this study, we isolated many halophiles capable of growth in a 20% NaCl medium adjusted to pH 4.5 from ...
Tópico(s): Methane Hydrates and Related Phenomena
2008 - BioMed Central | Saline Systems
Nobuhisa Iwata, Kazuhiro Suzuki, KENICHIRO MINEGISHI, Toru Kawanishi, Shuichi Hara, Takahiko Endo, Atsushi Takahashi,
We characterized the inducing effects of two musk analogues, musk xylene and musk ambrette, on phase I and phase II drug-metabolizing enzymes in rat liver and compared their effects with 3-methylcholanthrene, isosafrole and 2(3)-tertbutylhydroxyanisole (BHA) at 0.1 mmol/kg dose level. Musk xylene and isosafrole increased more efficiently the metabolic activation of 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1) to mutagen than that of benzo(a)pyrene. Musk ambrette increased both the activation ...
Tópico(s): Chemical Reactions and Isotopes
1993 - Elsevier BV | European Journal of Pharmacology Environmental Toxicology and Pharmacology
Jie Zheng, Kenji Kitajima, Eiko Sakai, Tohru Kimura, Naoko Minegishi, Masayuki Yamamoto, Toru Nakano,
Abstract The zinc finger transcription factor GATA-1 is essential for both primitive (embryonic) and definitive (adult) erythropoiesis. To define the roles of GATA-1 in the production and differentiation of primitive and definitive erythrocytes, we established GATA-1-null embryonic stem cell lines in which GATA-1 was able to be conditionally expressed by using the tetracycline conditional gene expression system. The cells were subjected to hematopoietic differentiation by coculturing on OP9 stroma ...
Tópico(s): Hemoglobinopathies and Related Disorders
2005 - Elsevier BV | Blood
M. Sheikh Mohamed, Srivani Veeranarayanan, Aby Cheruvathoor Poulose, Yutaka Nagaoka, Hiroaki Minegishi, Yasuhiko Yoshida, Toru Maekawa, D. Sakthi Kumar,
Gliomas have been termed recurrent cancers due to their highly aggressive nature. Their tendency to infiltrate and metastasize has posed significant roadblocks to in attaining fool proof treatment solutions. An initiative to curb such a scenario was successfully demonstrated in vitro, utilizing a multi-conceptual gold nanoparticle based photo-thermal and drug combination therapy. Gold nanoparticles (Au NPs) were synthesized with a highly environmentally benign process. The Au NPs were PEGylated and ...
Tópico(s): Nanoplatforms for cancer theranostics
2013 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - General Subjects
M. Arif Ashraf, Kana Umetsu, Olena Ponomarenko, Michiko Saito, Mohammad Aslam, Olga Antipova, Natalia V. Dolgova, Cheyenne D. Kiani, Susan Nehzati, Keitaro Tanoi, Katsuyuki Minegishi, Kotaro Nagatsu, Takehiro Kamiya, Toru Fujiwara, Christian Luschnig, Karen Tanino, Ingrid J. Pickering, Graham N. George, Abidur Rahman,
Arsenic contamination is a major environmental issue, as it may lead to serious health hazard. The reduced trivalent form of inorganic arsenic, arsenite, is in general more toxic to plants compared with the fully oxidized pentavalent arsenate. The uptake of arsenite in plants has been shown to be mediated through a large subfamily of plant aquaglyceroporins, nodulin 26-like intrinsic proteins (NIPs). However, the efflux mechanisms, as well as the mechanism of arsenite-induced root growth inhibition, ...
Tópico(s): Plant nutrient uptake and metabolism
2019 - Elsevier BV | Plant Communications
Nobuhisa Iwata, KENICHIRO MINEGISHI, Kazuhiro Suzuki, Yasuo Ohno, Toru Kawanishi, Atsushi Takahashi,
The effect of musk xylene on contents of both cytochrome P-450IA1 and cytochrome P-450IA2 in rat liver was investigated using Western blotting analysis. Rats were treated i.p. for five consecutive days with either 50, 100 or 200 mg musk xylene/kg body weight. Musk xylene increased both total cytochrome P-450 and cytochrome b5 contents in rat liver microsomes. Musk xylene induced cytochrome P-450IA2 (384 pmol/mg protein) strongly and preferentially and the ratio of cytochrome P450IA2/P-450IA1 was ...
Tópico(s): Metabolomics and Mass Spectrometry Studies
1992 - Elsevier BV | Biochemical and Biophysical Research Communications
M. Sheikh Mohamed, Ankur Baliyan, Srivani Veeranarayanan, Aby Cheruvathoor Poulose, Yutaka Nagaoka, Hiroaki Minegishi, Yasuhiko Yoshida, Toru Maekawa, D. Sakthi Kumar,
Tópico(s): Quantum Dots Synthesis And Properties
2012 - | Nanomaterials and the Environment
Yuka Igarashi, Toru Uchiyama, Tomoko Minegishi, Sirirat Takahashi, Nobuyuki Watanabe, Toshinao Kawai, Masafumi Yamada, Tadashi Ariga, Masafumi Onodera,
Clinical improvement in stem cell gene therapy (SCGT) for primary immunodeficiencies depends on the engraftment levels of genetically corrected cells, and tracing the transgene in each hematopoietic lineage is therefore extremely important in evaluating the efficacy of SCGT. We established a single cell-based droplet digital PCR (sc-ddPCR) method consisting of the encapsulation of a single cell into each droplet, followed by emulsion PCR with primers and probes specific for the transgene. A fluorescent ...
Tópico(s): CRISPR and Genetic Engineering
2017 - Cell Press | Molecular Therapy — Methods & Clinical Development
M. Sheikh Mohamed, Srivani Veeranarayanan, Ankur Baliyan, Aby Cheruvathoor Poulose, Yutaka Nagaoka, Hiroaki Minegishi, Seiki Iwai, Yasuhiro Shimane, Yasuhiko Yoshida, Toru Maekawa, D. Sakthi Kumar,
Macromolecular BioscienceVolume 14, Issue 12 p. 1696-1711 Full Paper Structurally Distinct Hybrid Polymer/Lipid Nanoconstructs Harboring a Type-I Ribotoxin as Cellular Imaging and Glioblastoma-Directed Therapeutic Vectors M. Sheikh Mohamed, M. Sheikh Mohamed Bio Nano Electronics Research Center, Graduate School of Interdisciplinary New Science Toyo University, Kawagoe, Saitama, 350-8585 JapanSearch for more papers by this authorSrivani Veeranarayanan, Srivani Veeranarayanan Bio Nano Electronics ...
Tópico(s): Toxin Mechanisms and Immunotoxins
2014 - Wiley | Macromolecular Bioscience
Toshiaki Higashi, Yutaka Nagaoka, Hiroaki Minegishi, Akinobu Echigo, Ron Usami, Toru Maekawa, Tatsuro Hanajiri,
The polymerase chain reaction (PCR) method is widely used for the reproduction and amplification of specific DNA segments in vitro, and a novel PCR method using nanomaterials such as gold nanoparticles has recently been reported. This paper reports on the regulation of PCR efficiency with superparamagnetic nanoparticles in a rotating magnetic field. The level of efficiency was successfully regulated in a rotating magnetic field by the authors, and decreased with increasing frequency of the field. ...
Tópico(s): Microfluidic and Bio-sensing Technologies
2011 - Elsevier BV | Chemical Physics Letters
Toshiaki Higashi, Hiroaki Minegishi, Yutaka Nagaoka, Takahiro Fukuda, Akinobu Echigo, Ron Usami, Toru Maekawa, Tatsuro Hanajiri,
The polymerase chain reaction (PCR) method is widely used for the reproduction and amplification of specific DNA segments, and a novel PCR method using nanomaterials such as gold nanoparticles has recently been reported. This paper reports on the effects of superparamagnetic nanoparticles on PCR amplification without an external magnetic field, and clarifies the mechanism behind the effects of superparamagnetic particle clusters on PCR efficiency by estimating the structures of such clusters in PCR. ...
Tópico(s): Anodic Oxide Films and Nanostructures
2012 - Multidisciplinary Digital Publishing Institute | Applied Sciences
Eishi Shiobara, Isamu Takagi, Yukiko Kikuchi, Takeshi Sasami, Shinya Minegishi, Toru Fujimori, Takeo Watanabe, Tetsuo Harada, Hiroo Kinoshita, Soichi Inoue,
The suppression of extreme ultraviolet (EUV) resist outgassing is one of the challenges in high-volume manufacturing with EUV lithography (EUVL), because it contributes to the contamination of the EUV scanner mirror optics, resulting in reflectivity loss. The outgas qualification using a witness sample (WS) has been developed into the general method for clarifying commercially available, chemically amplified resists. In our recent study, a resist outgas model is proposed and tested to investigate the ...
Tópico(s): X-ray Spectroscopy and Fluorescence Analysis
2015 - The Society of Photopolymer Science and Technology (SPST) | Journal of Photopolymer Science and Technology
Toru Fujimori, Toru Tsuchihashi, Shinya Minegishi, Takashi Kamizono, Toshiro Itani,
This study describes the use of a novel ultra-high sensitive 'metal resist' for use in extreme ultraviolet (EUV) lithography. Herein, the development of a metal resist has been studied for improving the sensitivity when using metal-containing non-chemically amplified resist materials; such materials are metal-containing organic–inorganic hybrid compounds and are referred to as EUVL Infrastructure Development Center, Inc. (EIDEC) standard metal EUV resist (ESMR). The novel metal resist's ultra-high sensitivity ...
Tópico(s): Integrated Circuits and Semiconductor Failure Analysis
2016 - SPIE | Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE
Akira Yoshikawa, Kazuyuki Suzuki, Aki Abe, Toru Tanaka, Kohei Yamaguchi, Toru Tanaka, Yoshihide Ishikawa, Kiyoshi Minegishi, Yuhko Gotanda, Hisao Yugi, Shigeharu Uchida, Masahiro Satake, Hiroyuki Mizoguchi, Kenji Tadokoro,
summary . The government of Japan started a selective vaccination programme to prevent mother‐to‐infant infection by hepatitis B virus (HBV) since January 1986. The effect of the programme on first‐time blood donors has not been examined in detail. Data of first‐time blood donors aged 16–25 years from 1996 to 2007 were extracted from the Japanese Red Cross (JRC) donors' database. Principal component analysis (PCA) was used to visualize the birth‐year‐dependent group of rate of HBV‐positive donors. According ...
Tópico(s): Vaccine Coverage and Hesitancy
2009 - Wiley | Transfusion Medicine
T. Ikuyama, Toru Watanabe, Yukiko Minegishi, H. Osanai,
The effect of voluntary exercise on 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB)-induced hepatomas was investigated in male Jc1:Wistar rats. Beginning at 10 weeks of age, animals were divided into two groups (sedentary and exercise) and housed in individual cages. Food intake and wheel exercise were automatically controlled in the cages of the exercise group. Body weights were monitored throughout the study. Food availability was controlled in order to equate length and weight gain. From 27 weeks ...
Tópico(s): Alcohol Consumption and Health Effects
1993 - SAGE Publishing | Experimental Biology and Medicine
Teppei Sugano, Masahiro Seike, Yoshinobu Saito, Takeru Kashiwada, Yasuhiro Terasaki, Natsuki Takano, Kakeru Hisakane, Satoshi Takahashi, Toru Tanaka, Susumu Takeuchi, Akihiko Miyanaga, Yuji Minegishi, Rintaro Noro, Kaoru Kubota, Akihiko Gemma,
Interstitial lung disease (ILD) induced by immune checkpoint inhibitors (ICIs) is a potentially life-threatening adverse event. The purpose of this study was to evaluate whether the development of immune-related adverse events (irAEs), especially ILD, was associated with treatment efficacy and to research the features and risk factors of ILD in advanced non-small cell lung cancer (NSCLC).Between December 2015 and November 2018, 130 advanced NSCLC patients were treated with nivolumab, pembrolizumab or ...
Tópico(s): Brain Metastases and Treatment
2020 - Wiley | Thoracic Cancer
Kunihiko Moriya, Makiko Suzuki, Y. Watanabe, Takeshi Takahashi, Yoko Aoki, Toru Uchiyama, Satoru Kumaki, Yoji Sasahara, Masayoshi Minegishi, Shigeo Kure, Shigeru Tsuchiya, Kazuo Sugamura, Naoto Ishii,
Mixed-lineage-leukemia (MLL) fusion oncogenes are intimately involved in acute leukemia and secondary therapy-related acute leukemia. To understand MLL-rearranged leukemia, several murine models for this disease have been established. However, the mouse leukemia derived from mouse hematopoietic stem cells (HSCs) may not be fully comparable with human leukemia. Here we developed a humanized mouse model for human leukemia by transplanting human cord blood-derived HSCs transduced with an MLL-AF10 oncogene ...
Tópico(s): CAR-T cell therapy research
2012 - Public Library of Science | PLoS ONE
Ikuo Kumakura, Masakatsu Minegishi, Kazuo Iwasaki, Hirokazu Shoji, Hiromitsu Miyaki, Norio Yoshimoto, Hirofumi Sashikuma, Noriaki Katayama, Akira Isoe, Toru Hayashi, Toshihiro Yamaoka, Tetsuya Akaso,
Structures and Materials Research Center of the National Aerospace Laboratory of Japan (NAL) conducted vertical drop tests of fuselage sections of a NAMC YS-11 A-200 transport airplane. This test program is a part of research activities in NAL on the structural crashworthiness of transport aircraft. In addition a cooperative research related to this test program has been carried out by NAL and Kawasaki Heavy Industries, Ltd.(KHI). The main objectives of this program are to develop optimal numerical ...
Tópico(s): Nuclear and radioactivity studies
2003 - | SAE technical papers on CD-ROM/SAE technical paper series
Ikuo Kumakura, Masakatsu Minegishi, Kazuo Iwasaki, Hirokazu Shoji, Norio Yoshimoto, Hiroyuki Terada, Hirofumi Sashikuma, Akira Isoe, Toshihiro Yamaoka, Noriaki Katayama, Toru Hayashi, Tetsuya Akaso,
Tópico(s): Tribology and Lubrication Engineering
2002 - | SAE technical papers on CD-ROM/SAE technical paper series
Takehiro Tozuka, Teppei Sugano, Rintaro Noro, Natsuki Takano, Kakeru Hisakane, Satoshi Takahashi, Toru Tanaka, Takeru Kashiwada, Susumu Takeuchi, Shinobu Kunugi, Yuji Minegishi, Yoshinobu Saito, Kaoru Kubota, Masahiro Seike, Akihiko Gemma,
An 82-year-old man with a recurrence of pulmonary pleomorphic carcinoma was treated with pembrolizumab. He achieved partial response after three cycles of pembrolizumab. However, he developed febrile neutropenia. A bone marrow aspiration sample revealed a decrease of mature neutrophils, and anti-neutrophil antibody was detected in blood. Computed tomography scans revealed consolidation in the right lung. Pathological findings in lung biopsy tissue revealed organizing pneumonia. Pembrolizumab-induced ...
Tópico(s): Blood disorders and treatments
2018 - Oxford University Press | Oxford Medical Case Reports
Hiromichi Wakui, Takahiro Yamaji, Kengo Azushima, Kazushi Uneda, Kotaro Haruhara, Akiko Nakamura, Kohji Ohki, Sho Kinguchi, Ryu Kobayashi, Shingo Urate, Toru Suzuki, Daisuke Kamimura, Shintaro Minegishi, Tomoaki Ishigami, Tomohiko Kanaoka, Kohei Matsuo, Tomoyuki Miyazaki, Tetsuya Fujikawa, Akio Yamashita, Kouichi Tamura,
Abstract Chronic kidney disease (CKD) progresses to end-stage renal failure via renal tubulointerstitial fibrosis. Malnutrition, inflammation, and arteriosclerosis interact to exacerbate the poor prognosis of CKD, and their effective management is thus essential. The traditional Japanese medicine Rikkunshito (RKT) exerts appetite-stimulating effects via ghrelin, which attenuates inflammation and fibrosis. We evaluated the therapeutic effect of RKT in unilateral ureter obstruction (UUO)-induced renal ...
Tópico(s): Dietary Effects on Health
2020 - Nature Portfolio | Scientific Reports
Wei Du, Satoru Kumaki, Toru Uchiyama, Akihiro Yachie, Chung Yeng Looi, S. Kawai, Masayoshi Minegishi, Narayanaswamy Ramesh, Raif S. Geha, Yoji Sasahara, Shigeru Tsuchiya,
Wiskott-Aldrich syndrome (WAS) is caused by mutations in the gene encoding WAS protein (WASP ). Recently, somatic mosaicism caused by reversions or second-site mutations has been reported in some inherited disorders including WAS. In this article, we describe somatic mosaicism in a 15-year-old WAS patient due to a second-hit mutation in the initiation codon. The patient originally had a single-base deletion (c.11delG; p.G4fsX40) in the WAS (WASP) gene, which resulted in a frameshift and abrogated protein ...
Tópico(s): Cell Image Analysis Techniques
2006 - Wiley | Human Mutation
Hajime Utsuno, Toru Kageyama, Keiicchi Uchida, Namiko Ishii, Saki Minegishi, Koichi Uemura, Koichi Sakurada,
Forensic facial approximation is a technique used to estimate the antemortem facial features of unknown skeletal remains. In recent years, many researchers have reported nasal tip predictions with positive results. However, the morphological nasal features of the skull can vary widely, and it is hard to obtain accurate values using facial approximation techniques. We assumed that these variations are due to an over-dependence on the values obtained from a single distance metric factor in an anatomical ...
Tópico(s): Nasal Surgery and Airway Studies
2018 - Elsevier BV | Forensic Science International
Masashi Takano, Kaichiro Yamamoto, Tsutomu Tabata, Yuji Minegishi, Takuma Yokoyama, Eiji Hirata, Takeshi Ikeda, Muneaki Shimada, Kouzo Yamada, Satoshi Morita, Yukio Ando, Koji Hirata, Masahiro Sugihara, Toru Sugiyama, Yasuo Ohashi, Yuh Sakata,
Aim Irinotecan-induced severe toxicities are possibly related to UGT1A1*6 and *28 genotypes. However, the correlation between UGT1A1 polymorphisms and the risk of toxicities induced by low-dose irinotecan plus platinum combination therapy still remains controversial. This prospective observational study aimed to examine the correlation between UGT1A1 genotypes and clinical outcomes of low-dose irinotecan (median 60 mg/m2, range 25–115 mg/m2) plus platinum in Japanese patients with solid tumors. Methods ...
Tópico(s): Neuroendocrine Tumor Research Advances
2016 - Wiley | Asia-Pacific Journal of Clinical Oncology
Toshiaki Higashi, Hiroaki Minegishi, Akinobu Echigo, Yutaka Nagaoka, Takahiro Fukuda, Ron Usami, Toru Maekawa, Tatsuro Hanajiri,
Here the authors present a nanomaterial-assisted PCR technique based on the use of thermal generation from magnetic nanoparticles (MNPs) under AC magnetic fields. In this approach, MNPs work as internal nano thermal generators to realize PCR thermal cycling. In order to suppress the non-specific absorption of DNA synthetic enzymes, MNPs are decorated with bovine serum albumin (BSA), forming BSA/MNP complexes. Under high-frequency AC magnetic fields, these complexes work as internal nano thermal generators, ...
Tópico(s): Innovative Microfluidic and Catalytic Techniques Innovation
2015 - Elsevier BV | Chemical Physics Letters
Teppei Sugano, Masahiro Seike, Rintaro Noro, Syota Kaburaki, Takehiro Tozuka, Akihiko Takahashi, Natsuki Takano, Toru Tanaka, Takeru Kashiwada, Susumu Takeuchi, Yuji Minegishi, Yoshinobu Saito, Kaoru Kubota, Yasuhiro Terasaki, Akihiko Gemma,
Abstract: We herein describe the case of a 67-year-old woman with advanced lung adenocarcinoma who developed interstitial lung disease (ILD) with alveolar hemorrhage induced by pembrolizumab. She received four courses of pembrolizumab therapy and achieved a partial response. She had no respiratory symptoms; however, chest radiography and computed tomography (CT) revealed ground-glass opacities (GGOs) and crazy-paving pattern. Based on findings of bloody bronchoalveolar lavage fluid and transbronchial ...
Tópico(s): Lung Cancer Treatments and Mutations
2018 - Dove Medical Press | OncoTargets and Therapy
Yang Pan, Akiko Suga, Itaru Kimura, Chojiro Kimura, Yuriko Minegishi, Mao Nakayama, Kazutoshi Yoshitake, Daisuke Iejima, Naoko Minematsu, Megumi Yamamoto, Fumihiko Mabuchi, Mitsuko Takamoto, Yukihiro Shiga, Makoto Araie, Kenji Kashiwagi, Makoto Aihara, Toru Nakazawa, Takeshi Iwata,
Normal-tension glaucoma (NTG) is a heterogeneous disease characterized by retinal ganglion cell (RGC) death leading to cupping of the optic nerve head and visual field loss at normal intraocular pressure (IOP). The pathogenesis of NTG remains unclear. Here, we describe a single nucleotide mutation in exon 2 of the methyltransferase-like 23 (METTL23) gene identified in 3 generations of a Japanese family with NTG. This mutation caused METTL23 mRNA aberrant splicing, which abolished normal protein production ...
Tópico(s): Epigenetics and DNA Methylation
2022 - American Society for Clinical Investigation | Journal of Clinical Investigation