Izo Kimijima, Tohru Ohtake, Hideto Sagara, Toru Watanabe, S Takenoshita,
Intracrine mechanisms which accelerate cancer cell growth are becoming well known in breast cancer research. In this study, microscopic invasive patterns of breast cancer cells into surrounding stromal tissues were evaluated.174 patients (110 patients < or = 50, and 64 > or = 60 years) underwent total or partial mastectomy from 1985 to 1993. In these patients the microscopic invasive pattern (especially scattered invasion into fat, SIF), influence on hormone receptor status, survival, and adjuvant therapy ...
Tópico(s): Cancer Cells and Metastasis
2000 - Karger Publishers | Oncology
Yoshimitsu Sagara, Toru Komatsu, Tasuku Ueno, Kenjiro Hanaoka, Takashi Kato, Tetsuo Nagano,
Covalent attachment of mechanoresponsive luminescent organic or organometallic compounds to other materials is a promising approach to develop a wide variety of mechanoresponsive luminescent materials. Here, we report covalently linkable mechanoresponsive micelles that change their photoluminescence from yellow to green in response to mechanical stimulation under aqueous conditions. These micelles are composed of a dumbbell-shaped amphiphilic pyrene derivative having amine groups at the peripheral ...
Tópico(s): Dendrimers and Hyperbranched Polymers
2014 - American Chemical Society | Journal of the American Chemical Society
Yoshimitsu Sagara, Toru Komatsu, Takuya Terai, Tasuku Ueno, Kenjiro Hanaoka, Takashi Kato, Tetsuo Nagano,
Abstract Molecular assemblies that change photoluminescence color in response to thermal or mechanical stimulation without dissociation into the monomeric states in water are described herein. A dumbbell‐shaped amphiphilic compound forms micellar molecular assemblies in water and exhibits yellow photoluminescence derived from excimer formation of the luminescent core, which contains a 2,6‐diethynylanthracene moiety. Annealing of the aqueous solution induces a photoluminescence color change from ...
Tópico(s): Polydiacetylene-based materials and applications
2014 - Wiley | Chemistry - A European Journal
Yoshimitsu Sagara, Toru Komatsu, Tasuku Ueno, Kenjiro Hanaoka, Takashi Kato, Tetsuo Nagano,
Abstract Switching of the luminescence properties of molecular materials in response to mechanical stimulation is of fundamental interest and also has a range of potential applications. Herein, a water‐soluble mechanochromic luminescent pyrene derivative having two hydrophilic dendrons is reported. This pyrene derivative is the first example of a mechanochromic luminescent organic compound that responds to relative humidity. Mechanical stimulation (grinding) of this pyrene derivative in the solid ...
Tópico(s): Dendrimers and Hyperbranched Polymers
2013 - Wiley | Advanced Functional Materials
Takuma Hashimoto, Daiki D. Horikawa, Yuki Saito, Hirokazu Kuwahara, Hiroko Kozuka‐Hata, Tadasu Shin‐I, Yohei Minakuchi, Kazuko Ohishi, Ayuko Motoyama, Tomoyuki Aizu, Atsushi Enomoto, Koyuki Kondo, Sae Tanaka, Yuichiro Hara, Shigeyuki Koshikawa, Hiroshi Sagara, Toru Miura, Shin‐ichi Yokobori, Kiyoshi Miyagawa, Yutaka Suzuki, Takeo Kubo, Masaaki Oyama, Yuji Kohara, Asao Fujiyama, Kazuharu Arakawa, Toshiaki Katayama, Atsushi Toyoda, Takekazu Kunieda,
Tardigrades, also known as water bears, are small aquatic animals. Some tardigrade species tolerate almost complete dehydration and exhibit extraordinary tolerance to various physical extremes in the dehydrated state. Here we determine a high-quality genome sequence of Ramazzottius varieornatus, one of the most stress-tolerant tardigrade species. Precise gene repertoire analyses reveal the presence of a small proportion (1.2% or less) of putative foreign genes, loss of gene pathways that promote ...
Tópico(s): Spaceflight effects on biology
2016 - Nature Portfolio | Nature Communications
Muneomi Sagara, Hiroaki Mukaidani, Toru Yamamoto,
This paper discusses the infinite horizon stochastic Nash games with state-dependent noise. After establishing the asymptotic structure along with the positive semidefiniteness for the solutions of the cross-coupled stochastic algebraic Riccati equations (CSAREs), a new algorithm that combines Newton’s method with two fixed point algorithms for solving the CSAREs is derived. As a result, it is shown that the proposed algorithm attains quadratic convergence and the reduced-order computations for sufficiently ...
Tópico(s): Complex Systems and Time Series Analysis
2007 - Elsevier BV | Applied Mathematics and Computation
Shigeyoshi Sakaki, Takahito Sagara, Toru Arai, Tatsuya Kojima, T. OGATA, Katsutoshi Ohkubo,
The hydrogenation of polycyclic aromatic hydrocarbons (PAHs) (naphthalene, anthracene, and phenanthrene) catalyzed by metalloporphyrins based on cobalt, nickel or iron was studied in aqueous solutions at room temperature and ambient pressure. Nickel porphyrin (P1) activated by nanosized zero-valent iron (nano-ZVI) and cobalt porphyrins (P2) and (P4) activated by titanium(III) citrate as the electron donor were demonstrated to be promising catalysts for the reductive hydrogenation of PAHs. In particular, ...
Tópico(s): Electrocatalysts for Energy Conversion
1992 - Science Press | Journal of Molecular Catalysis
Yufu Sagara, Toshifumi Kimura, Toru Fujikawa, Kazuhito Noguchi, Norikazu Ohtake,
Tópico(s): Sphingolipid Metabolism and Signaling
2003 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
Katsurô Iwasaki, Tôru Hirano, Kozo Sagara, Yukimasa Nishimura,
To study the cause of osteonecrosis of the femoral head in spontaneously hypertensive rats, the site and mechanism of the occlusion of the blood vessels feeding the femoral head were investigated histologically and microangiographically. Tracing the blood vessels using serial sections revealed that the lateral epiphyseal vessels disappeared immediately before entry into the ossific nucleus. As the reparative process advanced, the blood vessels from the lateral side of the head entered the ossific ...
Tópico(s): Dermatological and COVID-19 studies
1992 - Lippincott Williams & Wilkins | Clinical Orthopaedics and Related Research
Y Fukuda, Akihiko Tanaka, Tetsuya Homma, Keisuke Kaneko, Tomoki Uno, Akiko Fujiwara, Yoshitaka Uchida, Shintaro Suzuki, Toru Kotani, Hironori Sagara,
Acute hypoxemic respiratory failure (AHRF) with bilateral opacities causes fatalities in the intensive care unit (ICU). It is often difficult to identify the causes of AHRF at the time of admission. The SpO 2 to FiO 2 (S/F) ratio has been recently used as a non-invasive and alternative marker of the PaO 2 /FiO 2 (P/F) ratio in acute respiratory failure. This retrospective cohort study was conducted from October 2010 to March 2019 at the Showa University Hospital, Tokyo, Japan. We enrolled 94 AHRF patients ...
Tópico(s): Emergency and Acute Care Studies
2021 - Public Library of Science | PLoS ONE
K. Sagara, Masahiro Hara, Noriyuki Takahashi, Tōru Motobayashi, Fujio Takéutchi, F. Soga, Y. Nogami,
Absolute cross sections of the 4 He( d , p α) n reaction have been measured at E d =8.9 MeV in order to study the reaction mechanism at low energy. A gas target in a cell with very thin wall (0.25 mg/cm 2 ) is used to detect low energy α-particles. In the coincidence spectra, prominent peaks are observed corresponding to the strong n -α final state interaction. Shapes of the spectra are well reproduced by the simple impulse approximation and the single-level R-matrix theory, but the absolute values as ...
Tópico(s): Advanced Chemical Physics Studies
1977 - Physical Society of Japan | Journal of the Physical Society of Japan
Yufu Sagara, Takeshi Sagara, Toshiaki Mase, Toshifumi Kimura, Tomoshige Numazawa, Toru Fujikawa, Kazuhito Noguchi, Norikazu Ohtake,
To discover a highly selective M(3) antagonist, a combinatorial library was prepared. The library was designed to identify a novel structural class of M(3) antagonists by exploring the spatial arrangement of the pharmacophores in known M(3) antagonists. After the evaluation of 1000 library members, a potent M(3) antagonist, 14a (K(i) = 0.31 nM), with novel structural features was identified. Compound 14a showed high selectivity for M(3) receptors over the other muscarinic receptor subtypes (M(1)/M(3) = ...
Tópico(s): Pharmacological Receptor Mechanisms and Effects
2002 - American Chemical Society | Journal of Medicinal Chemistry
Shoji Natsugoe, M Sagara, M. Shimada, Toru Kumanohoso, Koki Tokuda, Daisuke Wakamatsu, Yoshihisa Tezuka, Chikara Kusano, Heiji Yoshinaka, Masaya Baba, T Fukumoto, Takashi Aikou,
The expression of desmoglein I (DGI) in both primary turners and metastatic lymph node of esophageal carcinoma was studied immunohistochemically in 102 patients using an anti-DGI monoclonal antibody. Normal squamous epithelial cells strongly expressed DGI at their cell-cell boundaries. DGI expression in the tumors was divided into DGI (++), DGI (+), DGI (-) according to the staining intensity. DGI (+) or DG (-) tumors had lymph node metastases more frequently than DGI (++) tumors (p<0.01). DGI expression was the same or of less ...
Tópico(s): Advanced Glycation End Products research
1995 - Spandidos Publishing | International Journal of Oncology
Tôru Hirano, Katsurô Iwasaki, Kozo Sagara, Yukimasa Nishimura, Toshiyuki Kumashiro,
AbstractThe cause of the vascular occlusion in necrosis of the femoral head of growing, spontaneously hypertensive rats was investigated histologically using serial sections. The lateral epiphyseal vessels, which supply the proximal femoral epiphysis, disappeared immediately before entry into the femoral heads. In fresh osteonecrosis the pathway of the vessels between the margin of the articular cartilage and the growth plate was replaced with granulation or scar tissue.We conclude that the vascular ...
Tópico(s): Hip disorders and treatments
1989 - Taylor & Francis | Acta Orthopaedica Scandinavica
Camilla Malinowsky, Anders Kottorp, Rumi Tanemura, Eric Asaba, Toru Nagao, Kazue Noda, Jiro Sagara, Peter Bontje, Lena Rosenberg, Louise Nygård,
Background/Objective The Everyday Technology Use Questionnaire (ETUQ), which evaluates the perceived relevance of and the perceived ability in everyday technology (ET) use, has demonstrated acceptable psychometric properties in Swedish studies of older adults. The aim of this study was to examine the reliability and validity of the ETUQ in a Japanese context in older Japanese adults. Methods A sample of older Japanese adults (n = 164) including persons with (n = 32) and without (n = 132) cognitive impairment ...
Tópico(s): Dementia and Cognitive Impairment Research
2015 - SAGE Publishing | Hong Kong Journal of Occupational Therapy
Masamichi Baba, Shoji Natsugoe, Chikara Kusano, Kazusada Shirao, Soji Sane, Toru Kumanohoso, Yoshihisa Tezuka, M Sagara, Heiji Yoshinaka, Toshitaka Fukumoto, Takashi Aikou,
Tópico(s): Head and Neck Cancer Studies
1995 - Springer Science+Business Media | Surgery Today
Muneomi Sagara, Hiroaki Mukaidani, Toru Yamamoto,
In this paper, a high-order soft constrained Nash strategy for weakly coupled large-scale systems is investigated. In order to solve the cross-coupled sign-indefinite algebraic Riccati equations (CSAREs) corresponding to strategy, the iterative algorithm on the basis of the Newton’s method is first applied. Second, the recursive algorithm for solving the CSAREs is also established to reduce the amount of algebraic computation as compared with the Newton’s method. Using these iterative solutions, ...
Tópico(s): Numerical methods for differential equations
2008 - Academy Publisher | Journal of Computers
Yufu Sagara, Takeshi Sagara, Minaho Uchiyama, Sachie Otsuki, Toshifumi Kimura, Toru Fujikawa, Kazuhito Noguchi, Norikazu Ohtake,
Identification of a novel class of potent and highly selective M3 muscarinic antagonists is described. First, the structure−activity relationship in the cationic amine core of our previously reported triphenylpropionamide class of M3 selective antagonists was explored by a small diamine library constructed in solid phase. This led to the identification of M3 antagonists with a novel piperidine pharmacophore and significantly improved subtype selectivity from a previously reported class. Successive ...
Tópico(s): Adenosine and Purinergic Signaling
2006 - American Chemical Society | Journal of Medicinal Chemistry
Shoji Natsugoe, Takashi Aikou, Mario Shimada, Toru Kumanohoso, Yoshihisa Tezuka, M Sagara, Heiji Yoshinaka, Masamichi Baba, Toshitaka Fukumoto,
Abstract Desmoglein I (DGI) is major component of the desmosomal membrane core that plays an important role in epithelial cell adhesion. The aim of this study was to explore the correlation between the expression of DGI and the clinicopathological findings of esophageal cancer. DGI expression was immunohistochemically examined using an anti‐DGI monoclonal antibody in 139 patients with squamous cell carcinoma of the esophagus. Normal squamous epithelial cells strongly expressed DGI at their cell‐cell ...
Tópico(s): S100 Proteins and Annexins
1994 - Wiley | Journal of Surgical Oncology
Yoshiko Sagara, Nobuo Fuse, Motohiko Seimiya, Syunji Yokokura, Kei Watanabe, Toru Nakazawa, Masayuki Kurusu, Takashi Seki, Makoto Tamai,
Visual evoked potential (VEP) testing is used frequently and is an important ophthalmologic physiological test to examine visual functions objectively. The VEP is a complicated waveform consisting of negative waveform named N75 and N135, and positive waveform named P100. Delayed P100 latency and greatly attenuated amplitude on VEP are known characteristics for diagnosing optic nerve disease. Acupuncture has been used to treat wide clinical symptoms with minimal side effects. The confirmation of the ...
Tópico(s): Glaucoma and retinal disorders
2006 - Tohoku University | The Tohoku Journal of Experimental Medicine
Takatoshi Kasai, K. Inoue, Toru Kumagai, M. Kato, Fusae Kawana, Mina Sagara, Sugao Ishiwata, Masuo Ohno, Tetsu Yamaguchi, Shin‐ichi Momomura, Koji Narui,
Obstructive sleep apnea (OSA) induces inflammation and vascular damage that might contribute to an increased risk of cardiovascular disease (CVD). However, the mechanisms linking OSA and CVD are not fully understood. Pentraxin3 may play a significant role in vascular inflammation and damage. Currently, there is lack of data on pentraxin3 and its role in vascular damage associated with OSA.We enrolled 50 males with OSA and 25 controls matched for age and body mass index (BMI). Patients with OSA were ...
Tópico(s): Cardiovascular Disease and Adiposity
2010 - Oxford University Press | American Journal of Hypertension
Hidetaka Imai, Masahiro Okaji, Tōru Kishii, H. Sagara, Haruhiko Aikawa, Ryo Kato,
Tópico(s): Surface Roughness and Optical Measurements
1990 - Springer Science+Business Media | International Journal of Thermophysics
Takeshi Etou, Masahiro Iizuka, Atsushi Ohshima, Hitoshi Yagisawa, Hiro‐o Yamano, Toru Ishii, Shiho Sagara,
The coexistence of idiopathic thrombocytopenic purpura (ITP) and active ulcerative colitis (UC) has been reported. We herein report a rare case of UC accompanied by ITP and Helicobacter pylori (H. pylori) infection. A female UC patient was diagnosed with ITP. At that time, the UC was almost in remission and we suspected that the ITP was caused by some factor other than UC. Accordingly, we found H. pylori infection and administered H. pylori eradication therapy. Consequently, the patient's serum platelet ...
Tópico(s): Gastrointestinal Bleeding Diagnosis and Treatment
2013 - The Japanese Society of Internal Medicine | Internal Medicine
Muneomi Sagara, Hiroaki Mukaidani, Toru Yamamoto,
This paper addresses linear quadratic control with state-dependent noise for singularly perturbed stochastic systems (SPSS). First, the asymptotic structure of the stochastic algebraic Riccati equation (SARE) is established for two cases. Second, a new iterative algorithm that combines Newton's method with the fixed point algorithm is established. As a result, the quadratic convergence and the reduced-order computation in the same dimension of the subsystem are attained. As another important feature, ...
Tópico(s): Stability and Control of Uncertain Systems
2009 - Institute of Electronics, Information and Communication Engineers | IEICE Transactions on Fundamentals of Electronics Communications and Computer Sciences
Muneomi Sagara, Hiroaki Mukaidani, Toru Yamamoto,
This paper discusses the infinite horizon static output feedback stochastic Nash games involving state-dependent noise in weakly coupled large-scale systems. In order to construct the strategy, the conditions for the existence of equilibria have been derived from the solutions of the sets of cross-coupled stochastic algebraic Riccati equations (CSAREs). After establishing the asymptotic structure along with the positive semidefiniteness for the solutions of CSAREs, recursive algorithm for solving ...
Tópico(s): Stability and Controllability of Differential Equations
2008 - Institute of Electronics, Information and Communication Engineers | IEICE Transactions on Fundamentals of Electronics Communications and Computer Sciences
Megumi Oshima, Yasunori Iwata, Kengo Furuichi, Norihiko Sakai, Miho Shimizu, Akinori Hara, Shinji Kitajima, Tadashi Toyama, Yasuyuki Shinozaki, Akihiro Sagara, Umeda Eri, Shuichi Kaneko, Satoko Arai, Toru Miyazaki, Takashi Wada,
Tópico(s): Systemic Lupus Erythematosus Research
2016 - Springer Science+Business Media | Clinical and Experimental Nephrology
Masahiro Iizuka, Takeshi Etou, Hitoshi Yagisawa, Toru Ishii, Shiho Sagara,
A 29-year-old woman with ulcerative colitis underwent total colectomy with ileal-pouch-anal canal anastomosis in 1999. After the surgery, she developed refractory pouchitis. We administered metronidazole, mesalamine and ciprofloxacin; however, her clinical symptoms improved only very slightly. We initiated treatment with infliximab in June 2011 and discontinued the antibiotics. Thereafter, the patient's abdominal symptoms quickly improved. We discontinued the infliximab therapy in June 2012, after ...
Tópico(s): Autoimmune and Inflammatory Disorders
2014 - The Japanese Society of Internal Medicine | Internal Medicine
Masatomo Fujiwara, Takuji Sugidachi, Toru Arai, Kensaku Shimizu, Mayumi Hayashi, Yasuhisa Noma, Hideaki Kawagita, Kazuo Sagara, Taro Nakagawa, Satoshi Okumura, Yoichi Inai, Takashi Shibata, S. Iwasaki, Atsushi Shimizu,
Abstract. A meteorological balloon-borne cloud sensor called the cloud particle sensor (CPS) has been developed. The CPS is equipped with a diode laser at ∼ 790 nm and two photodetectors, with a polarization plate in front of one of the detectors, to count the number of particles per second and to obtain the cloud-phase information (i.e. liquid, ice, or mixed). The lower detection limit for particle size was evaluated in laboratory experiments as ∼ 2 µm diameter for water droplets. For the current model ...
Tópico(s): Atmospheric Ozone and Climate
2016 - Copernicus Publications | Atmospheric measurement techniques
Takahiro Niimura, Yoshito Zamami, Toru Imai, Kanako Nagao, Masafumi Kayano, Hidenori Sagara, Mitsuhiro Goda, Naoto Okada, Masayuki Chuma, Kenshi Takechi, Masaki Imanishi, Toshihiro Koyama, Tadashi Koga, Hironori Nakura, Toshiaki Sendo, Keisuke Ishizawa,
Although the 2016 Japanese guidelines for the management of sepsis recommend de-escalation of treatment after identification of the causative pathogen, adherence to this practice remain unknown. The objective of this study was to evaluate the benefits of de-escalating treatment for sepsis patients at an advanced critical care and emergency medical centre.Based on electronic patient information, 85 patients who were transported to the centre by ambulance, and diagnosed with sepsis between January ...
Tópico(s): Pneumonia and Respiratory Infections
2018 - Canadian Society for Pharmaceutical Sciences | Journal of Pharmacy & Pharmaceutical Sciences
Shiori Fukumoto, Masayuki Ohbayashi, Akira Okada, Noriko Kohyama, Tatsuro Tamatsukuri, Hideki Inoue, Akihito Kato, Toru Kotani, Hironori Sagara, Kenji Dohi, Mari Kogo,
Purpose: Creatinine clearance (CCr) and pharmacokinetic parameters are markedly affected by pathophysiological changes in patients with sepsis. However, only a few reports have assessed renal function in patients with sepsis using the measured CCr. Furthermore, the administration regimen has not been sufficiently evaluated using a population PK (PPK) model across renal function broad ranges. Therefore, this study was performed to construct a meropenem PPK model for patients with sepsis using the measured ...
Tópico(s): Antibiotic Resistance in Bacteria
2022 - Lippincott Williams & Wilkins | Therapeutic Drug Monitoring