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Artigo Revisado por pares

Finn H. Brække, Leena Finér,

... sheets on two geographically separated sites, one in Trøgstad, SE‐Norway, and the other near Joensuu, SE‐ ... 31 May), ranged from 64–74% on the Trøgstad site and from 64–82 % on the Joensuu ... in 1984 probably covered such effects on the Trøgstad site. The cellulose decomposition rate was high during ... from cellulose decomposition, the aerobic limit on the Trøgstad site was at depth‐interval 15–30 cm, ...

Tópico(s): Coastal wetland ecosystem dynamics

1990 - Taylor & Francis | Scandinavian Journal of Forest Research

Artigo Acesso aberto Revisado por pares

Anthony Ravussin, Anna Hayman Robertson, Asia‐Sophia Wolf, Kristine Blix, Ingrid Fadum Kjønstad, Guri Solum, Berit Feiring, Bjørn Heine Strand, Fridtjof Lund‐Johansen, Ludvig A. Munthe, Per Magnus, Lill Trogstad, Siri Mjaaland,

BackgroundOlder age is associated with poorer outcomes to COVID-19 infection. The Norwegian Institute of Public Health established a longitudinal cohort of adults aged 65–80 years to study the effects of the COVID-19 pandemic. Here we describe the characteristics of the cohort in general, and specifically the immune responses at baseline and after primary and booster vaccination in a subset of longitudinal blood samples, and the epidemiological factors affecting these responses.Methods4551 participants ...

Tópico(s): COVID-19 epidemiological studies

2023 - Elsevier BV | The Lancet Healthy Longevity

Artigo Acesso aberto Revisado por pares

Lill Trogstad, Ida Laake, Anna Hayman Robertson, Siri Mjaaland, Ida Henriette Caspersen, Lene Kristine Juvet, Per Magnus, Kristine Blix, Berit Feiring,

Many signals of menstrual disturbances as possible side effects of vaccination against COVID-19 have been reported. Our objective was to compare the risk of menstrual disturbances before and after vaccination among women aged 18-30 years in Oslo, Norway. We used electronic questionnaires to collect reports of menstrual disturbances from 3972 women aged 18-30 years, participating in the population-based Norwegian Young Adult Cohort. We examined the occurrence of menstrual disturbances (heavier bleeding ...

Tópico(s): Reproductive System and Pregnancy

2023 - Elsevier BV | Vaccine

Artigo

Athanasios Kousathanas, Erola Pairo‐Castineira, Konrad Rawlik, A. Stuckey, Christopher A. Odhams, Susan Walker, Clark D Russell, Tomas Malinauskas, Yang Wu, Jonathan Millar, Xia Shen, Katherine S. Elliott, Fiona Griffiths, Wilna Oosthuyzen, Kirstie Morrice, Seán Keating, Bo Wang, Daniel R. Rhodes, Lucija Klarić, Marie Zechner, Nick Parkinson, Afshan Siddiq, Peter Goddard, Sally Donovan, David M. Maslove, Alistair Nichol, Malcolm G. Semple, Tala Zainy, F. Maleady-Crowe, Linda Todd, Shahla Salehi, Julian C. Knight, Greg Elgar, G. C. Chan, Prabhu Arumugam, Christine Patch, Augusto Rendon, David Bentley, Clare Kingsley, Jack A. Kosmicki, Julie Horowitz, Aris Baras, Gonçalo R. Abecasis, Manuel A. R. Ferreira, Anne E. Justice, Tooraj Mirshahi, Matthew T. Oetjens, Daniel J. Rader, Marylyn D. Ritchie, Anurag Verma, Tom Fowler, Manu Shankar‐Hari, Charlotte Summers, Charles Hinds, Peter Horby, Lowell Ling, Daniel F. McAuley, Hugh Montgomery, Peter Openshaw, Paul Elliott, Timothy Walsh, Albert Tenesa, J. Kenneth Baillie, Colin B. Begg, Sara Clohisey, Charles Hinds, Peter Horby, Julian C. Knight, Lowell Ling, David M. Maslove, Daniel F. McAuley, Johnny Millar, Hugh Montgomery, Alistair Nichol, Peter Openshaw, Alexandre C. Pereira, Chris P. Ponting, Kathy Rowan, Malcolm G. Semple, Manu Shankar‐Hari, Charlotte Summers, Timothy Walsh, Latha Aravindan, Ruth Armstrong, Heather Biggs, Ceilia Boz, Adam Brown, Richard E. Clark, Audrey Coutts, J. Terrence Coyle, Louise Cullum, Sukamal Das, Nicky Day, Lorna Donnelly, Esther Duncan, Angie Fawkes, Paul Finernan, Max Head Fourman, Anita Furlong, James Furniss, Bernadette Gallagher, Tammy Gilchrist, Ailsa Golightly, Fiona Griffiths, Katarzyna Hafezi, Debbie Hamilton, Ross Hendry, Andy Law, Dawn Law, R. M. Law, Sarah Law, Rebecca Lidstone-Scott, Louise MacGillivray, Alan Maclean, Hanning Mal, Sarah McCafferty, Ellie Mcmaster, Jen Meikle, Shona C. Moore, Kirstie Morrice, Lee Murphy, Sheena Murphy, Mybaya Hellen, Wilna Oosthuyzen, Chenqing Zheng, Jiantao Chen, Nick Parkinson, Trevor Paterson, Katherine Schon, Andrew Stenhouse, Mihaela Das, Maaike Swets, Helen Szoor-McElhinney, Filip Taneski, Lance Turtle, Tony Wackett, Mairi Ward, Jane Weaver, Nicola Wrobel, Marie Zechner, Gill Arbane, Aneta Bociek, Sara Campos, Neus Grau, Tim Jones, Rosario Lim, Martina Marotti, Marlies Ostermann, Manu Shankar‐Hari, R. Chris Whitton, Zoe Alldis, Raine Astin-Chamberlain, Fatima Bibi, Jack Biddle, Sarah Blow, Matthew L. Bolton, Catherine Borra, Ruth Bowles, Maudrian Burton, Yasmin Choudhury, David Collier, Amber Cox, Amy Easthope, Patrizia Ebano, Stavros Fotiadis, Jana Gurasashvili, Rosslyn Halls, Pippa Hartridge, Delordson Kallon, Jamila Kassam, Ivone Lancoma-Malcolm, Maninderpal Matharu, P. May, Oliver Mitchelmore, Tabitha Newman, Mital Patel, Jane Pheby, Irene Pinzuti, Zoe Prime, Oleksandra Prysyazhna, Julian Shiel, Melanie Taylor, Carey Tierney, S. M. Wood, Anne Zak, Olivier Zongo, Stephen Bonner, Keith Hugill, Jessica Jones, Steven Liggett, Evie Headlam, Nageswar Bandla, Minnie Gellamucho, Michelle Davies, C. C. Thompson, Marwa Abdelrazik, Dhanalakshmi Bakthavatsalam, Munzir Elhassan, Arunkumar Ganesan, Anne Haldeos, Jerónimo Moreno-Cuesta, Dharam Purohit, Rachel Vincent, Kugan Xavier, Rohit Kumar, Alasdair Frater, Malik Saleem, Emma Carter, Samuel Jenkins, Zoe Lamond, Alanna Wall, Jaime Fernandez-Roman, David Hamilton, Emily Johnson, Brian Johnston, Maria Lopez Martinez, Suleman Mulla, David Shaw, Alicia Waite, Victoria Waugh, Ingeborg Welters, Karen Williams, Anna Cavazza, Maeve Cockrell, Eleanor Corcoran, Maria Depante, Clare Finney, Ellen Jerome, Mark McPhail, Monalisa Nayak, Harriet Noble, Kevin O’Reilly, Evita Pappa, Rohit Saha, Sian Saha, John Smith, Abigail Knighton, David Antcliffe, Dorota Banach, Stephen J. Brett, Phoebe Coghlan, Ziortza Fernandez, Anthony Gordon, Roceld Rojo, Sonia Sousa Arias, Maie Templeton, Megan Meredith, Lucy Morris, Lucy Ryan, Amy Clark, Julia Sampson, Cecilia Peters, Martin Dent, Margaret Langley, Saima Ashraf, Shuying Wei, Angela Andrew, Archana Bashyal, Neil Davidson, Paula Hutton, Stuart McKechnie, Jean Wilson, David Baptista, Rebecca Crowe, Rita Fernandes, Rosaleen Herdman-Grant, Anna Joseph, Denise O’Connor, Meryem Allen, Adam Loveridge, India McKenley, Eriko Morino, Andrés Naranjo, Richard Simms, Kathryn Sollesta, Andrew Swain, Harish Venkatesh, Jacyntha Khera, Jonathan Fox, Gillian Andrew, J. Kenneth Baillie, Lucy Barclay, Marie Callaghan, Rachael Campbell, Sarah J. Clark, Dave Hope, Lucy Marshall, Corrienne McCulloch, Kate Briton, Jo Singleton, Sophie Birch, Lutece Brimfield, Zoe Daly, David Pogson, Steve Rose, Angela Nown,

Abstract Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care 1 or hospitalization 2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals ...

Nature Portfolio

Carta

Gita A. Pathak, Juha Karjalainen, Christine Stevens, Benjamin M. Neale, Mark J. Daly, Andrea Ganna, Shea J. Andrews, Masahiro Kanai, Mattia Cordioli, Renato Polimanti, Nadia V. Harerimana, Matti Pirinen, Rachel G. Liao, Karolina Chwiałkowska, Amy Trankiem, Mary K. Balaconis, Huy Nguyen, Matthew Solomonson, Kumar Veerapen, Brooke N. Wolford, Genevieve Roberts, Daniel J. Park, Catherine A. Ball, Marie V. Coignet, Shannon McCurdy, Spencer C. Knight, Raghavendran Partha, Brooke Rhead, Miao Zhang, Nathan Berkowitz, Michael Gaddis, Keith Noto, Luong Ruiz, Miloš Pavlović, Eurie L. Hong, Kristin A. Rand, Ahna R. Girshick, Harendra Guturu, Asher Haug Baltzell, Mari Niemi, Souad Rahmouni, Julien Guntz, Y Beguin, Mattia Cordioli, Sara Pigazzini, Lindokuhle Nkambule, Michel Georges, Michel Moutschen, Benoît Misset, Gilles Darcis, Julien Guiot, Samira Azarzar, Stéphanie Gofflot, Sabine Claassen, Olivier Malaise, Pascale Huynen, Christelle Meuris, Marie Thys, Jessica Jacques, Philippe Léonard, Frédéric Frippiat, Jean‐Baptiste Giot, Anne-Sophie Sauvage, Christian Von Frenckell, Yasmine Belhaj, Bernard Lambermont, Tomoko Nakanishi, David Morrison, Vincent Mooser, J. Brent Richards, Guillaume Butler‐Laporte, Vincenzo Forgetta, Rui Li, Biswarup Ghosh, Lætitia Laurent, Alexandre Bélisle, Danielle Henry, Tala Abdullah, Olumide Adeleye, Noor Mamlouk, Nofar Kimchi, Zaman Afrasiabi, Nardin Rezk, Branka Vulesevic, Meriem Bouab, Charlotte Guzman, Louis Petitjean, Chris Tselios, Xiaoqing Xue, Jonathan Afilalo, Marc Afilalo, Maureen Oliveira, Bluma Brenner, Nathalie Brassard, Madéleine Durand, Erwin Schurr, Pierre Lepage, Jiannis Ragoussis, Daniel Auld, Michaël Chassé, Daniel E. Kaufmann, G. Mark Lathrop, Darin Adra, Caroline Hayward, Joseph Glessner, Douglas M. Shaw, Archie Campbell, Marcela Morris, Hákon Hákonarson, David J. Porteous, Jennifer E. Below, Anne Richmond, Xiao Chang, Hannah Polikowski, Petty E. Lauren, Hung‐Hsin Chen, Wanying Zhu, Chloe Fawns‐Ritchie, Kari E. North, Joseph B. McCormick, Xiao Chang, Joseph R. Glessner, Hákon Hákonarson, Christopher R. Gignoux, Stephen J. Wicks, Kristy Crooks, Kathleen C. Barnes, Michelle Daya, Jonathan Shortt, Nicholas Rafaels, Amr Sameer, Paul R. H. J. Timmers, James F. Wilson, Albert Tenesa, Shona M. Kerr, Kenton D’Mellow, Doaa Shahin, Yasser M. El‐Sherbiny, Kathrin Aprile von Hohenstaufen, Ali Sobh, Madonna M. Eltoukhy, Lindokuhle Nkambul, Tamer Elhadidy, Mohamed S. Abd Elghafar, Jehan J. El‐Jawhari, Attia A. S. Mohamed, Marwa H. Elnagdy, Amr Samir, Mahmoud Abdel-Aziz, Walid T. Khafaga, Walaa M. El-Lawaty, Mohamed Torky, Mohamed El‐Shanshory, Amr M. Yassen, Mohamed Hegazy, Kamal Okasha, Mohammed Eid, Hanteera S. Moahmed, Carolina Medina‐Gómez, M. Arfan Ikram, André G. Uitterlinden, Reedik Mägi, Lili Milani, Andres Metspalu, Triin Laisk, Kristi Läll, Maarja Lepamets, Tõnu Esko, Ene Reimann, Paul Naaber, Edward Laane, Jaana Pesukova, Pärt Peterson, Kai Kisand, Jekaterina Tabri, Raili Allos, Kati Hensen, Joel Starkopf, Inge Ringmets, Anu Tamm, Anne Kallaste, Helene Alavere, Kristjan Metsalu, Mairo Puusepp, Chiara Batini, Martin D. Tobin, Laura D. Venn, Paul H. Lee, Nick Shrine, Alexander T. Williams, Anna L. Guyatt, Catherine John, Richard Packer, Altaf Ali, Robert C. Free, Xueyang Wang, Louise V. Wain, Edward J. Hollox, Catherine Bee, Emma L. Adams, Aarno Palotie, Samuli Ripatti, Sanni Ruotsalainen, Kati Kristiansson, Sami Koskelainen, Markus Perola, Kati Donner, Katja Kivinen, Aarno Palotie, Mari Kaunisto, Carlo Rivolta, Pierre-Yves Bochud, Stéphanie Bibert, Noémie Boillat‐Blanco, Semira Gonseth, Werner C. Albrich, Mathieu Quinodoz, Dhryata Kamdar, Noémie Suh, Dionysios Neofytos, Véronique Erard, Cathy Voide, Pierre-Yves Bochud, Carlo Rivolta, Stéphanie Bibert, Mathieu Quinodoz, Dhryata Kamdar, Dionysios Neofytos, Véronique Erard, Cathy Voide, R. Friolet, Péter Vollenweider, Jl Pagani, Mauro Oddo, Friederike Meyer zu Bentrup, A. Conen, Olivier Clerc, Oscar Marchetti, A. Guillet, C. Guyat-Jacques, S. Foucras, M. Rime, J. Chassot, M. Jaquet, R. Merlet Viollet, Y. Lannepoudenx, L. Portopena, Pierre-Yves Bochud, Péter Vollenweider, Jl Pagani, F. Desgranges, Paraskevas Filippidis, Benoît Guéry, David Haefliger, Eleftheria Kampouri, Oriol Manuel, Aline Munting, Matthaios Papadimitriou‐Olivgeris, Jean Regina, L. Rochat-Stettler, V. Suttels, Eliana Tadini, J Tschopp, Mathias Van Singer, Benjamin Viala, Noémie Boillat‐Blanco, T. Brahier, Olivier Hügli, J. Y. Meuwly, O. Pantet, Semira Gonseth, Pierre‐Yves Bochud, Valérie D’Acremont, S. Estoppey Younes, Werner C. Albrich, Noémie Suh, A. Cerny, L. O’Mahony, C. von Mering, Pierre-Yves Bochud, Mirjam Frischknecht, G-R. Kleger, M. Filipovic, C. R. Kahlert, Hannah Wozniak, Tommaso Rochat Negro, J. Pugin, Konstantinos Bouras, C. Knapp, Thomas Egger, A. Perret, P. Montillier, C. di Bartolomeo, Beatrice Barda, Rafael de Cid, Anna Carreras,

Nature Portfolio

Artigo Acesso aberto Revisado por pares

Ingibjörg Magnúsdóttir, Anikó Lovik, Anna Bára Unnarsdóttir, Daniel L. McCartney, Helga Ask, Kadri Kõiv, Lea Arregui Nordahl Christoffersen, Sverre Urnes Johnson, Arna Hauksdóttir, Chloe Fawns‐Ritchie, Dorte Helenius, Juan González‐Hijón, Li Lu, Omid V. Ebrahimi, Asle Hoffart, David J. Porteous, Fang Fang, Jóhanna Jakobsdóttir, Kelli Lehto, Ole A. Andreassen, Ole Birger Pedersen, Thor Aspelund, Unnur Valdimarsdóttir, Ingibjörg Magnúsdóttir, Anikó Lovik, Anna Bára Unnarsdóttir, Daniel L. McCartney, Helga Ask, Kadri Kõiv, Lea Arregui Nordahl Christoffersen, Sverre Urnes Johnson, Andrew M. McIntosh, Anna K. Kähler, Archie Campbell, Arna Hauksdóttir, Chloe Fawns‐Ritchie, Christian Erikstrup, Dorte Helenius, Drew Altschul, Edda Björk Þórðardóttir, Elías Eyþórsson, Emma M. Frans, Gunnar Tómasson, Harpa Lind Jónsdóttir, Harpa Rúnarsdóttir, Henrik Hjalgrim, Hrönn Harõardóttir, Juan González‐Hijón, Karina Banasik, Khoa Manh Dinh, Li Lu, Lili Milani, Lill Trogstad, Maria Didriksen, Omid V. Ebrahimi, Patrick F. Sullivan, Per Magnus, Qing Shen, Ragnar Nesvåg, Reedik Mägi, Runólfur Pálsson, Sisse Rye Ostrowski, Thomas Werge, Asle Hoffart, David J. Porteous, Fang Fang, Jóhanna Jakobsdóttir, Kelli Lehto, Ole A. Andreassen, Ole Birger Pedersen, Thor Aspelund, Unnur Valdimarsdóttir,

Summary Background Long-term mental and physical health consequences of COVID-19 (long COVID) are a persistent public health concern. Little is still known about the long-term mental health of non-hospitalised patients with COVID-19 with varying illness severities. Our aim was to assess the prevalence of adverse mental health symptoms among individuals diagnosed with COVID-19 in the general population by acute infection severity up to 16 months after diagnosis. Methods This observational follow-up study ...

Tópico(s): Psychosomatic Disorders and Their Treatments

2022 - Elsevier BV | The Lancet Public Health

Artigo Acesso aberto Revisado por pares

Trung Tran, Eline Benno Vaage, Adi Mehta, Adity Chopra, Lisa Tietze, Anette Kolderup, Aina Karen Anthi, Marton König, Gro Owren Nygaard, Andreas Lind, Fredrik Müller, Lise Sofie Haug Nissen‐Meyer, Per Magnus, Lill Trogstad, Siri Mjaaland, Arne Søraas, Karsten Midtvedt, Anders Åsberg, Andreas Barratt‐Due, Asle W. Medhus, Marte Lie Høivik, Knut E.A. Lundin, Randi Fuglaas Karlsen, Reidun Dahle, Karin Danielsson, Kristine Thomassen, Grete Birkeland Kro, Rebecca Jane Cox, Fan Zhou, Nina Langeland, Pål Aukrust, Espen Melum, Tone Lise Åvitsland, Kristine Wiencke, Jan Cato Holter, Ludvig A. Munthe, Gunnveig Grødeland, Jan Terje Andersen, John Torgils Vaage, Fridtjof Lund‐Johansen,

Diagnostic assays currently used to monitor the efficacy of COVID-19 vaccines measure levels of antibodies to the receptor-binding domain of ancestral SARS-CoV-2 (RBDwt). However, the predictive value for protection against new variants of concern (VOCs) has not been firmly established. Here, we used bead-based arrays and flow cytometry to measure binding of antibodies to spike proteins and receptor-binding domains (RBDs) from VOCs in 12,000 serum samples. Effects of sera on RBD-ACE2 interactions were ...

Tópico(s): COVID-19 Clinical Research Studies

2022 - Nature Portfolio | npj Vaccines

Revisão Acesso aberto Revisado por pares

Jameela Sheikh, John Allotey, Tania Kew, Borja M. Fernández-Félix, Javier Zamora, Asma Khalil, Shakila Thangaratinam, Mali Abdollahain, Ary I. Savitri, Kjell Å. Salvesen, Sohinee Bhattacharya, Cuno S.P.M. Uiterwaal, Annetine Staff, Louise Bjørkholt Andersen, Elisa Llurba, G. Daskalakis, Maureen Macleod, B. Thilaganathan, J. Arenas Ramírez, Jacques Massé, François Audibert, Per Magnus, Line Sletner, Ahmet Baschat, Akihide Ohkuchi, Fionnuala M. McAuliffe, Jane West, Lisa Askie, Fionnuala Mone, Diane Farrar, Peter A. Zimmerman, Luc Smits, Catherine Riddell, John‏ Kingdom, Joris van de Post, Sebastián E. Illanes, Claudia Holzman, Sander M. J. van Kuijk, Lionel Carbillon, Pia Villa, Anne Eskild, Lucy C. Chappell, Federico Prefumo, Luxmi Velauthar, Paul T. Seed, Miriam F. van Oostwaard, Stefan Verlohren, Lucilla Poston, E. Ferrazzi, Christina Anne Vinter, Chie Nagata, Mark Brown, Karlijn C. Vollebregt, Satoru Takeda, Josje Langenveld, Mariana Widmer, Shigeru Saito, Camilla Haavaldsen, Guillermo Carroli, Jørn Olsen, Hans Wolf, Nelly Zavaleta, Inge Eisensee, Patrizia Vergani, Pisake Lumbiganon, Maria Makrides, Fabio Facchinetti, E Sequeira, Robert A. Gibson, Sergio Ferrazzani, T. Frusca, Ernesto Antônio Figueiró-Filho, Olav Lapaire, Hannele Laivuori, Jacob Alexander Lykke, Agustín Conde‐Agudelo, Alberto Galindo, Alfred K. Mbah, Ana Pilar Betrán, Ignacio Herraı̀z, Lill Trogstad, Gordon G.S. Smith, Eric A.P. Steegers, Read Salim, Tianhua Huang, Annemarijne Adank, Jun Zhang, Wendy S. Meschino, Joyce L. Browne, Rebecca Allen, Fabrício da Silva Costa, Kerstin Klipstein‐Grobusch, Jan Stener Jørgensen, Jean‐Claude Forest, Alice Rumbold, Ben Willem Mol, Yves Giguère, Wessel Ganzevoort, Anthony Odibo, Jenny Myers, SeonAe Yeo, Helena Teede, François Goffinet, Lesley McCowan, Eva Pajkrt, Bassam G. Haddad, Gustaaf Dekker, Emily Kleinrouweler, Édouard Lecarpentier, Claire T. Roberts, Henk Groen, Ragnhild Bergene Skråstad, Seppo Heinonen, Eero Kajantie, Louise C. Kenny, Dewi Anggraini, Athena P. Souka, José Guilherme Cecatti, Ilza Monterio, Arri Coomarasamy, Melanie Smuk, Athanasios Pillalis, F. Crovetto, Renato Souza, Lee Ann Hawkins, Rinat Gabbay- Benziv, Richard D. Riley, Kym I E Snell, Lucinda Archer, Francesc Figuera, Marleen M. H. J. van Gelder,

BackgroundExisting evidence on the effects of race and ethnicity on pregnancy outcomes is restricted to individual studies done within specific countries and health systems. We aimed to assess the impact of race and ethnicity on perinatal outcomes in high-income and upper-middle-income countries, and to ascertain whether the magnitude of disparities, if any, varied across geographical regions.MethodsFor this individual participant data (IPD) meta-analysis we used data from the International Prediction ...

Tópico(s): Pregnancy and preeclampsia studies

2022 - Elsevier BV | The Lancet

Artigo Acesso aberto Revisado por pares

Ida Henriette Caspersen, Per Magnus, Lill Trogstad,

Physical, psychological and cognitive symptoms have been reported as post-acute sequelae for COVID-19 patients but are also common in the general uninfected population. We aimed to calculate the excess risk and identify patterns of 22 symptoms up to 12 months after COVID-19. We followed more than 70,000 adult participants in an ongoing cohort study, the Norwegian Mother, Father and Child Cohort Study (MoBa) during the COVID-19 pandemic. Infected and non-infected participants registered presence of ...

Tópico(s): Psychosomatic Disorders and Their Treatments

2022 - Springer Science+Business Media | European Journal of Epidemiology

Artigo

Lill Trogstad,

Background Many signals of menstrual disturbances as possible side effects of vaccination against COVID-19 have been reported. Our objective was to estimate the association between vaccination and the occurrence of such disturbances among women aged 18-30 in Norway.Methods We used mobile-phone questionnaires to collect reports of menstrual disturbances from 5688 women aged 18-30 years, participating in the population-based Norwegian Young Adult Cohort. We estimated the relative risk of menstrual ...

Tópico(s): Vaccine Coverage and Hesitancy

2022 - RELX Group (Netherlands) | SSRN Electronic Journal

Artigo Acesso aberto Revisado por pares

Hassen Kared, Asia‐Sophia Wolf, Amin Alirezaylavasani, Anthony Ravussin, Guri Solum, Trung Tran, Fridtjof Lund‐Johansen, John Torgils Vaage, Lise Sofie Haug Nissen‐Meyer, Unni C. Nygaard, Olav Hungnes, Anna Hayman Robertson, Lisbeth Meyer Næss, Lill Trogstad, Per Magnus, Ludvig A. Munthe, Siri Mjaaland,

The SARS-CoV-2 Omicron variant has more than 15 mutations in the receptor binding domain of the Spike protein enabling increased transmissibility and viral escape from antibodies in vaccinated individuals. It is unclear how vaccine immunity protects against Omicron infection. Here we show that vaccinated participants at a super-spreader event have robust recall response of humoral and pre-existing cellular immunity induced by the vaccines, and an emergent de novo T cell response to non-Spike antigens. ...

Tópico(s): Vaccine Coverage and Hesitancy

2022 - Nature Portfolio | Nature Communications

Artigo Acesso aberto Revisado por pares

Ida Laake, Siri N. Skodvin, Kristine Blix, Ida Henriette Caspersen, Håkon K. Gjessing, Lene Kristine Juvet, Per Magnus, Siri Mjaaland, Anna Hayman Robertson, Jostein Starrfelt, Lill Trogstad, Berit Feiring,

Understanding how booster vaccination can prevent moderate and severe illness without hospitalization is crucial to evaluate the full advantage of mRNA boosters.

Tópico(s): Animal Virus Infections Studies

2022 - Oxford University Press | The Journal of Infectious Diseases

Artigo Acesso aberto Revisado por pares

Allison Portnoy, Kine Pedersen, Lill Trogstad, Bo T. Hansen, Berit Feiring, Ida Laake, Megan A. Smith, Stephen Sy, Mari Nygård, Jane J. Kim, Emily A. Burger,

Following the global call for action by the World Health Organization to eliminate cervical cancer (CC), we evaluated how each CC policy decision in Norway influenced the timing of CC elimination, and whether introducing nonavalent human papillomavirus (HPV) vaccine would accelerate elimination timing and be cost-effective. We used a multi-modeling approach that captured HPV transmission and cervical carcinogenesis to estimate the CC incidence associated with six past and future CC prevention policy ...

Tópico(s): Endometrial and Cervical Cancer Treatments

2021 - Elsevier BV | Preventive Medicine

Artigo Acesso aberto Revisado por pares

Lill Trogstad, Anna Hayman Robertson, Siri Mjaaland, Per Magnus,

To compare prevalence of skin, nose and gingival bleedings after receipt of adeno-vectored or mRNA-vaccines against COVID-19. The hypothesis is that milder symptoms indicating altered thrombocyte function may affect a larger proportion of vaccinated individuals than the recently reported severe cases with thrombosis and thrombocytopenia.Using an ongoing large, population-based cohort study, more than 80000 cohort participants were asked through electronic questionnaires about COVID-19 vaccination ...

Tópico(s): Intramuscular injections and effects

2021 - Elsevier BV | Vaccine

Artigo

Matteo D’Antonio, Jennifer Nguyen, Timothy D. Arthur, Hiroko Matsui, Agnieszka D’Antonio‐Chronowska, Kelly A. Frazer, Benjamin M. Neale, Mark J. Daly, Andrea Ganna, Christine Stevens, Gita A. Pathak, Shea J. Andrews, Masahiro Kanai, Mattia Cordioli, Andrea Ganna, Juha Karjalainen, Gita A. Pathak, Renato Polimanti, Shea J. Andrews, Mattia Cordioli, Matti Pirinen, Masahiro Kanai, Nadia V. Harerimana, Kumar Veerapen, Brooke N. Wolford, Huy Nguyen, Matthew Solomonson, Christine Stevens, Rachel G. Liao, Karolina Chwiałkowska, Amy Trankiem, Mary K. Balaconis, Caroline Hayward, Anne Richmond, Archie Campbell, Marcela Morris, Chloe Fawns‐Ritchie, Joseph Glessner, Douglas M. Shaw, Xiao Chang, Hannah Polikowski, Petty E. Lauren, Hung‐Hsin Chen, Wanying Zhu, Hákon Hákonarson, David J. Porteous, Jennifer E. Below, K.E. North, Joseph B. McCormick, Paul R. H. J. Timmers, James F. Wilson, Albert Tenesa, Kenton D’Mellow, Shona M. Kerr, Mari Niemi, Mattia Cordioli, Lindokuhle Nkambul, Kathrin Aprile von Hohenstaufen, Ali Sobh, Madonna M. Eltoukhy, Amr M. Yassen, Mohamed Hegazy, Kamal Okasha, Mohammed Eid, Hanteera S. Moahmed, Doaa Shahin, Yasser M. El‐Sherbiny, Tamer Elhadidy, Mohamed S. Abd Elghafar, Jehan J. El‐Jawhari, Attia A. S. Mohamed, Marwa H. Elnagdy, Amr Samir, Mahmoud Abdel-Aziz, Walid T. Khafaga, Walaa M. El-Lawaty, Mohamed Torky, Mohamed El‐Shanshory, Chiara Batini, Paul H. Lee, Nick Shrine, Alexander T. Williams, Martin D. Tobin, Anna L. Guyatt, Catherine John, Richard Packer, Altaf Ali, Robert C. Free, Xueyang Wang, Louise V. Wain, Edward J. Hollox, Laura D. Venn, Catherine Bee, Emma L. Adams, Mari Niemi, Ahmadreza Niavarani, Mattia Cordioli, Lindokuhle Nkambul, Bahareh Sharififard, Rasoul Aliannejad, Ali Amirsavadkouhi, Zeinab Naderpour, Hengameh Ansari Tadi, Afshar Etemadi-Aleagha, Saeideh Ahmadi, Seyed Behrooz Mohseni Moghaddam, Alireza Adamsara, Morteza Saeedi, Hamed Abdollahi, Abdolmajid Hosseini, Pajaree Chariyavilaskul, Monpat Chamnanphon, Thitima B. Suttichet, Vorasuk Shotelersuk, Monnat Pongpanich, Chureerat Phokaew, Wanna Chetruengchai, Watsamon Jantarabenjakul, Opass Putchareon, Pattama Torvorapanit, Thanyawee Puthanakit, Pintip Suchartlikitwong, Nattiya Hirankarn, Voraphoj Nilaratanakul, Pimpayao Sodsai, Ben Brumpton, Kristian Hveem, Cristen J. Willer, Brooke N. Wolford, Wei Zhou, Tormod Rogne, Erik Solligård, Bjørn Olav Åsvold, Malak Abedalthagafi, Manal Alaamery, Saleh A. Alqahtani, Dona Baraka, Fawz Al Harthi, Ebtehal Alsolm, Leen Abu Safieh, Albandary M. Alowayn, Fatimah Alqubaishi, Amal Al Mutairi, Serghei Mangul, Abdulraheem Alshareef, Mona Sawaji, Mansour Almutairi, Nora Aljawini, Nour Albesher, Yaseen M. Arabi, Ebrahim Mahmoud, Amin Khattab, Roaa T. Halawani, Ziab Z. Alahmadey, Jehad K. Albakri, Walaa A. Felemban, Bandar A. Suliman, Rana Hasanato, Laila Alawdah, Jahad Alghamdi, Deema AlZahrani, Sameera Aljohani, Hani Al-Afghani, May Alrashed, Nouf AlDhawi, Hadeel AlBardis, Sarah Alkwai, Moneera Alswailm, Faisal A. Almalki, Maha Albeladi, Iman Almohammed, Eman Barhoush, Anoud Albader, Salam Massadeh, Abdulaziz Almalik, Sara Jeza Alotaibi, Bader Alghamdi, Junghyun Jung, Mohammad Fawzy, Yunsung Lee, Per Magnus, Lill-Iren S. Trogstad, Øyvind Helgeland, Jennifer R. Harris, Massimo Mangino, Tim D. Spector, Duncan Emma, Sandra Smieszek, Bartlomiej Przychodzen, Christos Polymeropoulos, Vasilios M. Polymeropoulos, Mihael H. Polymeropoulos, Israel Fernández‐Cadenas, Jordi Pérez‐Tur, Laia Llucià‐Carol, Natàlia Cullell, Elena Muiño, Jara Cárcel‐Márquez, Marta L. DeDiego, L. Lloret Iglesias, Anna M. Planas, Álex Soriano, Verónica Rico, Daiana Agüero, Josep Lluís Bedini, Francisco Lozano, Carlos Domingo, Verónica Robles, Francisca Ruíz-Jaén, Leonardo Márquez, Juan Manuel López Gómez, Eliécer Coto, Guillermo M. Albaiceta, Marta García‐Clemente, David Dalmau, María J. Arranz, Beatriz Dietl, Alex Serra-Llovich, Pere Soler Masó, Roger Colobrán, Andrea Martín‐Nalda, Alba Parra-Martínez, David Bernardo, Silvia Rojo, Aida Fiz‐López, Elisa Arribas‐Rodríguez, Paloma Cal-Sabater, Tomás Segura, Esther González-Villa, Gemma Serrano‐Heras, Joan Martí‐Fàbregas, Elena Jiménez‐Xarrié, Alicia de Felipe Mimbrera, Jaime Masjuán, Sebastián García‐Madrona, Anna Domínguez-Mayoral, Joan Montaner, Paloma Menéndez-Valladares, Daniel I. Chasman, Julie E. Buring, Paul M. Ridker, Franco Giulianini, Howard D. Sesso, JoAnn E. Manson, Xiao Chang, Joseph R. Glessner, Hákon Hákonarson, Caroline Hayward, Anne Richmond, David J. Porteous, Archie Campbell, Chloe Fawns‐Ritchie, Carolina Medina‐Gómez, André G. Uitterlinden, M. Arfan Ikram, Kati Kristiansson, Sami Koskelainen, Markus Perola, Kati Donner, Katja Kivinen, Aarno Palotie, Samuli Ripatti, Sanni Ruotsalainen, Mari Kaunisto, FinnGen, Tomoko Nakanishi, Guillaume Butler‐Laporte, Vincenzo Forgetta, David Morrison, Biswarup Ghosh, Lætitia Laurent, Alexandre Bélisle, Danielle Henry, Tala Abdullah, Olumide Adeleye, Noor Mamlouk, Nofar Kimchi, Zaman Afrasiabi, Nardin Rezk Branka Vulesevic, Meriem Bouab, Charlotte Guzman, Louis Petitjean, Chris Tselios, Xiaoqing Xue, Erwin Schurr, Jonathan Afilalo, Marc Afilalo, Maureen Oliveira, Bluma Brenner, Pierre Lepage, Jiannis Ragoussis, Daniel Auld, Nathalie Brassard, Madéleine Durand, Michaël Chassé, Daniel E. Kaufmann,

Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types ( ...

Cell Press

Artigo Acesso aberto Revisado por pares

Anna Bára Unnarsdóttir, Anikó Lovik, Chloe Fawns‐Ritchie, Helga Ask, Kadri Kõiv, Kristen Hagen, Maria Didriksen, Lea Arregui Nordahl Christoffersen, Alexander Berg Garðarsson, Andrew M. McIntosh, Anna K. Kähler, Archie Campbell, Arna Hauksdóttir, Christian Erikstrup, Dorte Helenius Mikkelsen, Drew Altschul, Edda Björk Þórðardóttir, Emma M. Frans, Gerd Kvale, Gunnar Tómasson, Hanna Maria Kariis, Harpa Lind Jónsdóttir, Harpa Rúnarsdóttir, Ingibjörg Magnúsdóttir, Jarle Eid, Jóhanna Jakobsdóttir, Kaspar René Nielsen, Kathrine Agergård Kaspersen, Lili Milani, Lill-Iren Schou Trogstad, Yi Lu, Mie Topholm Bruun, Patrick F. Sullivan, Per Magnus, Qing Shen, Ragnar Nesvåg, Ragnhild Eek Brandlistuen, Reedik Mägi, Sisse Rye Ostrowski, Solveig Løkhammer, Stian Solem, Ted Reichborn‐Kjennerud, Thomas Hansen, Thomas Werge, Thor Aspelund, David J. Porteous, Fang Fang, Kelli Lehto, Ole A. Andreassen, Ole Birger Pedersen, Stéphanie Le Hellard, Unnur Valdimarsdóttir,

Tópico(s): Health disparities and outcomes

2021 - Oxford University Press | International Journal of Epidemiology

Revisão Acesso aberto Revisado por pares

Lene Kristine Juvet, Anna Hayman Robertson, Ida Laake, Siri Mjaaland, Lill Trogstad,

Background In 2009, a new influenza A H1N1 virus emerged causing a global pandemic. A range of monovalent influenza A H1N1pdm09 vaccines with or without adjuvants were developed. After the mass vaccination campaigns safety concerns related to H1N1pdm09 vaccines were reported. More than a decade later, reported AEFIs are still under scrutiny. We performed a systematic review aiming to synthesize the evidence on the safety of the H1N1pdm09 vaccines on reported outcomes from existing systematic reviews. ...

Tópico(s): Receptor Mechanisms and Signaling

2021 - Frontiers Media | Frontiers in Immunology

Revisão Acesso aberto Revisado por pares

Valgerður Steinthórsdóttir, Ralph McGinnis, Nicholas Williams, Lilja Stefánsdóttir, Guðmar Þorleifsson, Scott Shooter, João Fadista, Jon K. Sigurdsson, Kirsi Auro, Galina Berezina, Maria Carolina Borges, Suzannah Bumpstead, Jonas Bybjerg‐Grauholm, Irina Colgiu, Vivien A. Dolby, Frank Dudbridge, Stephanie M. Engel, Christopher Franklin, Michael L. Frigge, Yr Frisbæk, Reynir Tómas Geirsson, Frank Geller, Sólveig Grétarsdóttir, Daníel F. Guðbjartsson, Quaker E. Harmon, David M. Hougaard, Tatyana Hegay, Anna Helgadóttir, Sigrun Hjartardottir, Tiina Jääskeläinen, Hrefna Johannsdottir, Ingileif Jónsdóttir, Thorhildur Juliusdottir, Noor Kalsheker, A. K. Kasimov, John P. Kemp, Katja Kivinen, Kari Klungsøyr, Wai Lee, Mads Melbye, Zosia Miedzybrodska, Ashley Moffett, Dilbar Najmutdinova, F Nishanova, Thorunn A. Olafsdottir, Markus Perola, Fiona Broughton Pipkin, Lucilla Poston, Gordon Prescott, Saedís Saevarsdóttir, Damilya Salimbayeva, Paula J. Scaife, Line Skotte, Eleonora Staines-Urias, Ólafur Andri Stefánsson, Karina Meden Sørensen, Liv Cecilie Vestrheim Thomsen, Vinicius Tragante, Lill Trogstad, Nigel Simpson, Hannele Laivuori, Seppo Heinonen, Eero Kajantie, Juha Kere, Katja Kivinen, Anneli Pouta, Linda Morgan, Fiona Broughton Pipkin, Noor Kalsheker, James J. Walker, Sheila Macphail, Mark D. Kilby, Marwan Habiba, Catherine Williamson, Kevin M. O’Shaughnessy, Shaughn O’Brien, Alan C. Cameron, Christopher W.G. Redman, Martin Farrall, Mark J. Caulfield, Anna F. Dominiczak, Tamara Aripova, Juan P. Casas, Anna F. Dominiczak, James J. Walker, Unnur Þorsteinsdóttir, Ann‐Charlotte Iversen, Bjarke Feenstra, Debbie A. Lawlor, Heather A. Boyd, Per Magnus, Hannele Laivuori, Nodira Zakhidova, Gulnara Svyatova, Kāri Stefánsson, Linda Morgan,

Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, ...

Tópico(s): Gestational Diabetes Research and Management

2020 - Nature Portfolio | Nature Communications

Artigo Acesso aberto Revisado por pares

Nina Gunnes, Håkon K. Gjessing, Inger Johanne Bakken, Sara Ghaderi, Jon Michael Gran, Olav Hungnes, Per Magnus, Sven Ove Samuelsen, Anders Skrondal, Camilla Stoltenberg, Lill Trogstad, Allen J. Wilcox, Siri E. Håberg,

Previous studies of fetal death with maternal influenza have been inconsistent. We explored the effect of maternal influenza-like illness (ILI) in pregnancy on the risk of fetal death, distinguishing between diagnoses during regular influenza seasons and the 2009/2010 pandemic and between trimesters of ILI. We used birth records from the Medical Birth Registry of Norway to identify fetal deaths after the first trimester in singleton pregnancies (2006-2013). The Norwegian Directorate of Health provided ...

Tópico(s): Viral Infections and Outbreaks Research

2020 - Springer Science+Business Media | European Journal of Epidemiology

Artigo Acesso aberto Revisado por pares

Sara Ghaderi, Pål Berg‐Hansen, Inger Johanne Bakken, Per Magnus, Lill Trogstad, Siri E. Håberg,

Patients with multiple sclerosis (MS) are at increased risk of infections and related worsening of neurological function. Influenza infection has been associated with increased risk of various neurological complications. We conducted a population-based registry study to investigate the risk of acute hospitalization of MS patients in relation to influenza infection or pandemic vaccination in Norway. The entire Norwegian population in the years 2008-2014 was defined as our study population (N = 5,219, ...

Tópico(s): Viral Infections and Immunology Research

2019 - Springer Science+Business Media | European Journal of Epidemiology

Carta Acesso aberto Revisado por pares

Maharaj Kishan Bhan, Bireshwar Sinha,

... 35Crossref PubMed Scopus (554) Google Scholar, 4Haberg SE Trogstad L Gunnes N et al.Risk of fetal ...

Tópico(s): Vaccine Coverage and Hesitancy

2019 - Elsevier BV | The Lancet Global Health

Artigo Acesso aberto Revisado por pares

Grace M. Egeland, Svetlana Skurtveit, Anne Cathrine Staff, Geir Egil Eide, A. K. Daltveit, Kari Klungsøyr, Lill Trogstad, Per Magnus, Anne Lise Brantsæter, Margaretha Haugen,

The association between pregnancy complications and women's later cardiovascular disease has, primarily, been evaluated in studies lacking information on important covariates. This report evaluates the prospective associations between pregnancy-related risk factors (preeclampsia/eclampsia, gestational hypertension, pregestational and gestational diabetes mellitus, preterm delivery, and fetal growth restriction) and pharmacologically treated hypertension within 10 years after pregnancy, while adjusting ...

Tópico(s): Cardiovascular Issues in Pregnancy

2018 - Wiley | Journal of the American Heart Association

Artigo Acesso aberto Revisado por pares

Ida Laake, Gro Tunheim, Anna Hayman Robertson, Olav Hungnes, K. Waalen, Siri E. Håberg, Siri Mjaaland, Lill Trogstad,

The effects of maternal influenza infection on the fetus remain unclear. We studied mild influenza and influenza antibodies in relation to birth weight and risks of pre-eclampsia, preterm birth (PTB), and small for gestational age (SGA) birth among the unvaccinated participants in the Norwegian Influenza Pregnancy Cohort.Pregnant women attending a routine ultrasound were recruited from four hospitals in Norway shortly after the 2009 A(H1N1) pandemic. The present study was restricted to unvaccinated ...

Tópico(s): Respiratory viral infections research

2018 - BioMed Central | BMC Infectious Diseases

Artigo Revisado por pares

Regine Barlinn, Susanne Dudman, Lill Trogstad, Moustafa Gibory, Fredrik Müller, Per Magnus, Halvor Rollag,

CMV is the most common cause of congenital infection. During the past few decades, there has been a change in behaviour that possibly has affected the CMV infection rate of mother and child. We investigated 1350 randomly selected pregnant women from the Norwegian Mother and Child Cohort Study using an algorithm for detection of maternal and congenital CMV (cCMV) infection including both serology and nucleic acid amplification assay. The CMV IgG seroprevalence was 54% and 23 (3.7%) mothers seroconverted. ...

Tópico(s): Herpesvirus Infections and Treatments

2018 - Wiley | Apmis

Artigo Acesso aberto Revisado por pares

Berit Feiring, Ida Laake, Irene Kraus Christiansen, Mona Hansen, Jeanette Stålcrantz, Ole Herman Ambur, Per Magnus, Christine Monceyron Jonassen, Lill Trogstad,

In 2009, quadrivalent human papillomavirus (HPV) vaccine was introduced in a school-based single-cohort program targeting 12-year-old girls in Norway. We estimated the impact of the Norwegian HPV immunization program.Three birth cohorts of 17-year-old girls, 2 nonvaccine-eligible cohorts (born 1994 or 1996) and 1 vaccine-eligible cohort (born 1997) were invited to deliver urine samples. The samples were analyzed for 37 HPV genotypes. HPV prevalence was compared between birth cohorts and between vaccinated ...

Tópico(s): Genital Health and Disease

2018 - Oxford University Press | The Journal of Infectious Diseases

Artigo Acesso aberto Revisado por pares

Lill Trogstad, Inger Johanne Bakken, Nina Gunnes, Sara Ghaderi, Camilla Stoltenberg, Per Magnus, Siri E. Håberg,

Associations between influenza infection and sleep disorders are poorly studied. We investigated if pandemic influenza infection or vaccination with Pandemrix in 2009/2010 was associated with narcolepsy or hypersomnia in children and young adults. We followed the Norwegian population under age 30 from January 2008 through December 2012 by linking national health registry data. Narcolepsy diagnoses were validated using hospital records. Risks of narcolepsy or hypersomnia were estimated as adjusted ...

Tópico(s): Circadian rhythm and melatonin

2017 - Elsevier BV | Vaccine

Artigo Acesso aberto Revisado por pares

Miloje Savic, Jennifer L. Dembinski, Ida Laake, Olav Hungnes, Rebecca Jane Cox, Fredrik Oftung, Lill Trogstad, Siri Mjaaland,

Maternal influenza infection during pregnancy is associated with increased risk of morbidity and mortality. However, the link between the anti-influenza immune responses and health-related risks during infection is not well understood. We have analyzed memory T and NK cell mediated immunity (CMI) responses in pandemic influenza A(H1N1)pdm09 (pdm09) virus infected non-vaccinated pregnant women participating in the Norwegian Influenza Pregnancy Cohort (NorFlu). The cohort includes information on immunization, ...

Tópico(s): Immune Cell Function and Interaction

2017 - Public Library of Science | PLoS ONE

Artigo Acesso aberto Revisado por pares

Berit Feiring, Ida Laake, Inger Johanne Bakken, Margrethe Greve‐Isdahl, Vegard Bruun Wyller, Siri E. Håberg, Per Magnus, Lill Trogstad,

Vaccination has been suggested to be involved in the aetiology of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). HPV vaccine was introduced in the Norwegian Childhood Immunisation Programme and offered 12year old girls from 2009. We studied the association between HPV vaccination and risk of CFS/ME and also assessed medical history in relation to both risk of CFS/ME and HPV vaccine uptake.Individual data from national registries, including the Norwegian Population Registry, the Norwegian ...

Tópico(s): Pediatric health and respiratory diseases

2017 - Elsevier BV | Vaccine

Artigo Acesso aberto Revisado por pares

Qian Nie, Shikshya Shrestha, E.J. Tapper, CS Trogstad‐Isaacson, Kelly J. Bouchonville, AM Lee, Rongqian Wu, Calvin R. Jerde, Zhiquan Wang, P Kubica, SM Offer, RB Diasio,

Dihydropyrimidine dehydrogenase (DPD; DPYD gene) variants have emerged as reliable predictors of adverse toxicity to the chemotherapy agent 5-fluorouracil (5-FU). The intronic DPYD variant rs75017182 has been recently suggested to promote alternative splicing of DPYD. However, both the extent of alternative splicing and the true contribution of rs75017182 to DPD function remain unclear. In the present study we quantified alternative splicing and DPD enzyme activity in rs75017182 carriers utilizing ...

Tópico(s): Pancreatic and Hepatic Oncology Research

2017 - Wiley | Clinical Pharmacology & Therapeutics