National Library of Medicine (NCBI)
R. M. Langford, Esther Pogatzki‐Zahn, Adelaida Morte, Mariano Sust, Jesús Cebrecos, Anna Vaqué, Esther Ortiz, James Fettiplace, Shola Adeyemi, J.L. López-Cedrún, S. Bescós, Neus Gascón, Carlos R. Plata‐Saláman,
Co-crystal of tramadol-celecoxib (CTC) is the first analgesic co-crystal for acute pain. This completed phase 3 multicenter, double-blind trial ... tolerability of CTC in comparison with that of tramadol in the setting of moderate-to-severe pain ... twice-daily CTC 100 mg (44 mg rac-tramadol hydrochloride/56 mg celecoxib; n = 164), 150 mg ( ... or 200 mg (88/112 mg; n = 160); tramadol 100 mg four times daily (n = 159); or ... and key secondary endpoints. All were superior to tramadol for SPID0–4 (analysis of covariance least squares ...
Tópico(s): Pain Mechanisms and Treatments
2024 - Adis, Springer Healthcare | Advances in Therapy
National Library of Medicine (NCBI)
Giovanna Lucrezia Costa, Simona Di Pietro, Claudia Interlandi, Fabio Leonardi, Daniele Macrì, Vincenzo Ferrantelli, Francesco Macrı̀,
Tramadol produces a significant reduction in both sevoflurane and isoflurane minimum alveolar concentrations in dogs under experimental ... This study aims to compare the effects of tramadol administered as a constant rate infusion (CRI) with those of tramadol administered as a single intravenous bolus on physiological ... 100% oxygen. The group A (n = 20) received tramadol 4 mg/kg in a single intravenous bolus, whereas the group B (n = 20) received tramadol 1.5 mg/kg in an intravenous bolus followed by tramadol 2.6 mg/kg/h as a CRI. ...
Tópico(s): Anesthesia and Pain Management
2023 - Public Library of Science | PLoS ONE
Lingyi Li, Shelby Marozoff, Na Lu, Hui Xie, Jacek A. Kopec, Jolanda Cibere, John M. Esdaile, J. Antonio Aviña‐Zubieta,
Abstract Background The use of tramadol among osteoarthritis (OA) patients has been increasing rapidly around the world, but population-based studies on its safety profile among OA patients are scarce. We sought to determine if tramadol use in OA patients is associated with increased ... all OA patients between 2005 and 2013. The tramadol cohort (i.e., tramadol initiation) was matched with four comparator cohorts (i. ... 63% females). All-cause mortality was higher for tramadol compared to NSAIDs with rate differences (RDs/1000 ...
Tópico(s): Musculoskeletal pain and rehabilitation
2022 - BioMed Central | Arthritis Research & Therapy
Saereh Hosseindoost, Ardeshir Akbarabadi, Mitra‐Sadat Sadat‐Shirazi, Seyed Mojtaba Mousavi, Solmaz Khalifeh, Azarakhsh Mokri, Mahmoudreza Hadjighassem, Mohammad‐Reza Zarrindast,
Abstract Tramadol is a synthetic opioid with centrally acting analgesic activity that alleviates moderate to severe pain and treats ... of the other opioids. Like other opioid drugs, tramadol abuse has adverse effects on central nervous system components. Chronic administration of tramadol induces maladaptive plasticity in brain structures responsible for ... as the hippocampus. However, the mechanisms by which tramadol induces these alternations are not entirely understood. Here, we examine the effect of tramadol on apoptosis and synaptogenesis of hippocampal neuronal in ...
Tópico(s): Veterinary Pharmacology and Anesthesia
2022 - Wiley | Drug Development Research
Ahmed H. Abdelazim, Sherif Ramzy, Ahmed H. Abdel‐Monem, Ahmed A. Almrasy, Ashraf A. A. Abdel‐Fattah, Mohammed Shahin,
... of the pain. The combination of celecoxib and tramadol was recently approved by the Food and Drug ... first published quantitative analytical methods for celecoxib and tramadol.The UV absorption spectra of celecoxib and tramadol showed strong overlap. Mathematical simultaneous equation and ratio ... and 272 nm enabled the quantitative analysis of tramadol.The proposed methods were successfully applied to the selective quantitative analysis of celecoxib and tramadol in the synthetic mixtures and in the pharmaceutical ...
Tópico(s): Veterinary Pharmacology and Anesthesia
2022 - Oxford University Press | Journal of AOAC International
... reports in West African countries have suggested a tramadol abuse ‘crisis’ characterised by a precipitous rise in ... global opioid crisis. While the reported increase in tramadol abuse in West Africa is likely true, few studies have critically interrogated structural explanations for tramadol use by youth. Nascent academic literature has sought ... data sources to explore the pain that precedes tramadol abuse. Through a discourse analysis of 295 media ... 15 interviews (11 with youth who currently use tramadol and 4 with health system stakeholders), this study ...
Tópico(s): Psychology of Moral and Emotional Judgment
2022 - Public Library of Science | PLOS Global Public Health
Produção Nacional
Revisado por pares
Amir Raoofi, Ali Delbari, Davood Nasiry, Hamid Eslampour, Rahim Golmohammadi, Sara Sadat Javadinia, Reza Sadrzadeh, Mohammad‐Shafi Mojadadi, Auob Rustamzadeh, Maedeh Akhlaghi, Amin Mousavi Khaneghah, Vahid Ebrahimi, Mohammad Jafar Rezaie,
Tramadol, an opioid used as analgesic, can induce neurotoxic effects associated to cognitive dysfunction. Moreover, caffeine has ... we hypothesized that administration of caffeine can modulate tramadol-induced damages in cerebellum. For this study, forty ... divided into four groups: the control group, the tramadol group (50 mg/kg), the caffeine group (37.5 mg/kg), and the tramadol+caffeine group (50 mg/kg tramadol+37.5 mg/kg caffeine). At the end ... and behavioral function were significantly higher in the tramadol+caffeine group compared to the tramadol group. Autophagy- ...
Tópico(s): Biochemical effects in animals
2022 - Elsevier BV | Journal of Chemical Neuroanatomy
Yi‐Hsuan Huang, Sung-How Sue, Zih-Syuan Wu, Shih‐Ming Huang, Shih‐Yu Lee, Zhi‐Fu Wu,
... cancer patients. This study investigated the effect of tramadol on breast cancer progression and metastasis.The effects of tramadol on two different subtypes of human breast adenocarcinoma ... and cyclin-related proteins. The co-administration of tramadol and doxorubicin was studied to determine whether the ... doxorubicin dose might be reduced in combination with tramadol.The results showed that tramadol inhibited cell growth at concentrations more than 0. ... were inhibited in a dose-dependent manner by tramadol in both cell lines. The combination of tramadol ...
Tópico(s): Nanoplatforms for cancer theranostics
2022 - Frontiers Media | Frontiers in Oncology
Okhee Yoo, Edith K. Y. Tang, Sam Salman, Minh Ngoc Nguyen, David Sommerfield, Aine Sommerfield, R. Nazim Khan, Britta S. von Ungern‐Sternberg, Lee Yong Lim,
Summary Tramadol is a bitter atypical opioid analgesic drug and is prescribed to treat postoperative pain in children. However, in many countries there is no licensed paediatric tramadol formulation available. We have formulated a novel chewable ... based drug delivery system for the administration of tramadol to children. This pilot, single‐centre, open‐label, ... tolerability and comparative population pharmacokinetics of the novel tramadol chewable tablet against a compounded tramadol hydrochloride oral ...
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
2022 - Wiley | Anaesthesia
Eugene R. Viscusi, Oscar A. de León-Casasola, Jesús Cebrecos, Adam Jacobs, Adelaida Morte, Esther Ortiz, Mariano Sust, Anna Vaqué, Ira J. Gottlieb, Stephen Daniels, Joseph Gimbel, Derek Muse, Peter Winkle, Michael E. Kuss, Sebastián Videla, Neus Gascón, Carlos R. Plata‐Saláman,
Abstract Background Celecoxib‐tramadol co‐crystal (CTC) is a first‐in‐class analgesic co‐crystal of celecoxib and racemic tramadol with an improved pharmacologic profile, conferred by the ... 200 mg [112 mg celecoxib/88 mg rac‐tramadol hydrochloride] every 12 h), tramadol (50 mg every 6 h), celecoxib (100 mg ... screened and 637 randomized to CTC (n = 184), tramadol (n = 183), celecoxib (n = 181), or placebo (n = ... 95% confidence interval: −151.8, −126.5]) than tramadol (−109.1 [−121.7, −96.4]; p < 0. ... TEAEs) were 358 for CTC and 394 for tramadol. Drug‐related TEAEs occurred in 37.7% patients ...
Tópico(s): Opioid Use Disorder Treatment
2022 - Wiley | Pain Practice
Salah A. Sheweita, Yassmin A. El‐dafrawi, Osama A. El‐ghalid, Alaa A. Ghoneim, Ahmed Wahid,
Abstract Tramadol has been used by millions of patients as an analgesic drug to relief the severe pain caused ... garlic and selenium) against the toxic effects of tramadol on semen characteristics, steroid hormones, the protein expressions ... and histological methods were used in this study. Tramadol (1.5 mg/kg body weight) was administered ... decreased after 4, 8, and 12 weeks of tramadol treatment. In addition, the protein expressions of CYP ... were down-regulated in the testes of the tramadol-treated rabbits. On the other hand, pretreatment of ...
Tópico(s): Veterinary Medicine and Surgery
2022 - Nature Portfolio | Scientific Reports
R. M. Langford, Adelaida Morte, Mariano Sust, Jesús Cebrecos, Anna Vaqué, Esther Ortiz, James Fettiplace, Shola Adeyemi, Grzegorz Raba, Liudmila But‐Husaim, Neus Gascón, Carlos R. Plata‐Saláman,
... the efficacy and safety of co-crystal of tramadol-celecoxib (CTC)-a first-in-class analgesic co-crystal comprising racemic tramadol hydrochloride and celecoxib in a supramolecular network that ... 2:1 to oral CTC 100 mg (rac-tramadol hydrochloride 44 mg/celecoxib 56 mg) twice daily ( ... 200 mg (88/112 mg) BID; immediate-release tramadol 100 mg four times daily (QID); celecoxib 100 ... 4 , CTC 200 mg was not superior to tramadol but showed non-inferior efficacy (p < 0.001) ... 120-h period, despite a 5-day cumulative tramadol administration of 880 mg with CTC 200 mg ...
Tópico(s): Veterinary Pharmacology and Anesthesia
2022 - Wiley | European Journal of Pain
Anne Roussin, Thomas Soeiro, Charlotte Fouque, Émilie Jouanjus, Élisabeth Frauger, Nathalie Fouilhé, Michel Mallaret, Joëlle Micallef, Maryse Lapeyre‐Mestre,
... is to assess recent developments in non‐medical tramadol use, tramadol use disorder, illegal procurement and deaths. Methods This ... Network of: (1) validated reports of high‐risk tramadol use, (2) record systems collecting information from toxicology ... institutions (OPPIDUM). Results Despite a plateauing level of tramadol exposure in the French population, the proportion of tramadol reports increased 1.7‐fold (187 cases in ... in 2013 (95% CI: 0.65–3.84). Tramadol was the primary opioid in analgesic‐related deaths ...
Tópico(s): Intramuscular injections and effects
2022 - Wiley | British Journal of Clinical Pharmacology
Li‐Chun Liu, Zih-Syuan Wu, Jialin Chen, Zhi‐Fu Wu, Hou‐Chuan Lai, Yi‐Hsuan Huang,
Tramadol is a common anesthetic used to treat cancer pain, including endometrial cancer, but its function in ... study was to elucidate the antitumor effects of tramadol on human endometrial cancer cells. Colony formation, BrdU, ... study the response of endometrial cancer cells to tramadol. JC-1 and seahorse metabolic flux assays were used to detect the effect of tramadol on mitochondria in endometrial cancer cells. Combination index was used to detect the interaction of tramadol with chemotherapy drugs in endometrial cancer cells. In ...
Tópico(s): Drug-Induced Hepatotoxicity and Protection
2022 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Anne Mette Skov Sørensen, Mia Noergaard, Ditte Resendal Gotfredsen, Anette Kjærbye‐Thygesen, Espen Jimenez‐Solem, Bjarke Askaa, Henrik E. Poulsen, Henrik Horwitz, Jón Trærup Andersen,
OBJECTIVE: To investigate whether exposure to tramadol during early pregnancy is associated with an increased risk of spontaneous abortion or major congenital malformations. METHODS: The study is a nationwide ... Register was used to identify maternal exposure to tramadol. Pregnancies with maternal exposure to tramadol were matched with pregnancies without maternal exposure to tramadol in a ratio of up to 1:4 ... congenital malformations. RESULTS: A total of 36,467 (tramadol exposure n=7,310) and 18,907 (tramadol ...
Tópico(s): Pregnancy and Medication Impact
2022 - Lippincott Williams & Wilkins | Obstetrics and Gynecology
Shinichi Kawai, Satoshi Sobajima, Masashi Jinnouchi, Hideshi Nakano, Hideaki Ohtani, Mineo Sakata, Takeshi Adachi,
... inflammatory drugs may provide insufficient analgesia. Twice-daily tramadol hydrochloride (65% sustained-release/35% immediate-release) bilayer tablets are a novel formulation of tramadol developed for managing chronic pain. The objectives of ... points during a 1–3-week, open-label, tramadol dose-escalation period (100–300 mg/day) were randomized to continue tramadol or switched to placebo for 4 weeks (double- ... the dose-escalation and double-blind periods, respectively (tramadol 79; placebo 81). Kaplan–Meier analysis revealed superiority ...
Tópico(s): Anesthesia and Pain Management
2022 - Adis, Springer Healthcare | Clinical Drug Investigation
Tao Long, Rodrigo Cristofoletti, Brian Cicali, Véronique Michaud, Pamela Dow, Jacques Turgeon, Stephan Schmidt,
Tramadol is an opioid medication used to treat moderately severe pain. Cytochrome P450 (CYP) 2D6 inhibition could be important for tramadol, as it decreases the formation of its pharmacologically ... impact of allosteric and competitive CYP2D6 inhibition on tramadol and O-desmethyltramadol pharmacokinetics using quinidine and metoprolol ... perpetrator drugs. A physiologically based pharmacokinetic model for tramadol and O-desmethyltramadol was developed and verified in ... impact of allosteric and competitive CYP2D6 inhibition on tramadol and O-desmethyltramadol exposure. Our results show that ...
Tópico(s): Opioid Use Disorder Treatment
2021 - Wiley | The Journal of Clinical Pharmacology
Jesús Cebrecos, James D. Carlson, Gregorio Encina, Mounia Lahjou, Artur Sans, Mariano Sust, Anna Vaqué, Adelaida Morte, Neus Gascón, Carlos R. Plata‐Saláman,
PurposeCelecoxib-tramadol co-crystal (CTC) is a first-in-class co-crystal of celecoxib and racemic tramadol. This Phase 1 bioavailability study compared single-dose ... from the United States, immediate-release celecoxib and tramadol, taken alone and simultaneously to determine their systemic ... equivalent to 112-mg celecoxib and 88-mg tramadol; Treatment-1); 100-mg tramadol (Treatment-2); 100-mg celecoxib (Treatment-3); and 100-mg celecoxib plus 100-mg tramadol (Treatment-4). The PK parameters of interest were ...
Tópico(s): Veterinary Pharmacology and Anesthesia
2021 - Elsevier BV | Clinical Therapeutics
Myoung Hwa Kim, Jeong Rim Lee, Ki Jun Kim, Ji Hae Jun, Hye Jeong Hwang, Wootaek Lee, Seung Hyun Nam, Ju Eun Oh, Young Chul Yoo,
Abstract In our previous research showed that tramadol having potential anti-tumor effect was associated with enhancement of oncological prognosis in patients with breast cancer surgery. As these effects have not ... studies, we investigated the anti-tumor effect of tramadol in vivo. Female nude mice orthotopically inoculated with ... cells, were randomly divided into the control (saline), tramadol group 1 (1.5 mg kg −1 day −1 ), tramadol group 2 (3 mg kg −1 day −1 ), ... were then examined. Tumour growth was attenuated in tramadol-treated groups (P < 0.05). NK cell activity ...
Tópico(s): Chemokine receptors and signaling
2021 - Nature Portfolio | Scientific Reports
Samaneh Nakhaee, Christopher Hoyte, Richard C. Dart, Masoumeh Askari, Roland J. Lamarine, Omid Mehrpour,
... that acts upon the central nervous system (CNS), tramadol has gained popularity in treating moderate to severe ... intentional overdoses or intoxications. This review focuses on tramadol intoxication in humans and its effects on different ... the pharmacokinetics, mechanism of action, and incidence of tramadol toxicity with an in-depth look at its ... addition, the main approaches to the management of tramadol poisoning are described. Results Tramadol poisoning can affect multiple organ systems: gastrointestinal, central ...
Tópico(s): Opioid Use Disorder Treatment
2021 - Springer Science+Business Media | Forensic Toxicology
Marwa H. Bakr, Eman Radwan, Asmaa S. Shaltout, Alshaimaa A. Farrag, Amany Refaat Mahmoud, Tarek Hamdy Abd‐Elhamid, Maha Ali,
Tramadol is an opioid extensively used to treat moderate to severe pain; however, prolonged therapy is associated with several tissues damage. Chronic use of tramadol was linked to increased hospitalizations due to cardiovascular complications. Limited literature has described the effects of tramadol on the cardiovascular system, so we sought to ... actions and elucidate the underlying mechanisms. Mice received tramadol hydrochloride (40 mg/kg body weight) orally for ... in heart and aortic tissues after exposure to tramadol. Tramadol upregulated the expression of oxidative stress and ...
Tópico(s): Pain Mechanisms and Treatments
2021 - Nature Portfolio | Scientific Reports
Stuart L. Silverman, J. Bradford Rice, Alan G. White, Craig Beck, R.L. Robinson, Catherine Fernan, Patricia Schepman,
... 2019, the American College of Rheumatology conditionally recommended tramadol and conditionally recommended against nontramadol opioids for patients with hip and knee osteoarthritis. Although tramadol is known to be less prone to opioid ... outcomes, health care resource utilization, and costs of tramadol relative to nontramadol opioids. Administrative claims records for ... patients were analyzed: 4048 (28%) were initiated on tramadol, and 10,443 (72%) were initiated on nontramadol ... per cohort were analyzed. In each empirical analysis, tramadol patients did develop opioid use disorders; however, opioid ...
Tópico(s): Musculoskeletal pain and rehabilitation
2021 - Lippincott Williams & Wilkins | Pain
Ferguson Saapiire, Godfrey Namillah, Vincent Tanye, Abdulai Abubakari,
Tramadol has gained popularity among the drugs of the most active population especially the respondents in Ghana ... public health concern, and stakeholders are worried about tramadol abuse and its implications on health in the ... The study sought to measure the prevalence of tramadol/related substance abuse and the associated factors.A ... data.About 77.6% of the respondents abuse tramadol while 83.9% of the participants take at ... abuse were 5 times more likely to abuse tramadol [AOR = 5.15; 95% CI (1.501-17. ... history of any substance abuse. Respondents who take tramadol to enhance sex were 4 times more likely ...
Tópico(s): Animal testing and alternatives
2021 - Hindawi Publishing Corporation | Psychiatry Journal
... concern regarding the addiction and dependence potential of tramadol.This study sought to determine factors associated with tramadol abuse among commercial drivers and assistants in the ... participants, 114 (24.9%) indicated that they abused tramadol. The mean (± standard deviation) age of those who abused tramadol (25.14 ± 5.87 years) was significantly lower ... 001. The level of risk of dependence on tramadol among the abusers was high, as 49.1% ( ... 3.89; p = 0.009) were associated with tramadol abuse. Reasons given for using tramadol included pain ...
Tópico(s): Blood Pressure and Hypertension Studies
2021 - Adis, Springer Healthcare | Drugs - Real World Outcomes
Peng Du, Zilei Zhou, Zhenglu Wang, Zeqiong Xu, Qiuda Zheng, Xinyue Li, Jia He, Xiqing Li, Hongguang Cheng, Phong K. Thai,
The misuse of fentanyl and more recently tramadol in the population has caused an opioid crisis in several countries and drawn much public attention worldwide. However, there is a gap of information on the potential misuse of fentanyl and tramadol in China. This study aims to fill this gap by analysing fentanyl and tramadol in wastewater of major cities across China to ... of this potent opioid drug in China. Meanwhile, tramadol was found in most samples with concentrations ranging ... ng/L. The per capita daily consumption of tramadol estimated from wastewater across China ranged from 6 ...
Tópico(s): Anesthesia and Sedative Agents
2021 - Elsevier BV | The Science of The Total Environment
Assad Bio-Sya, Henri Joël Gandjo, Elvyre Klikpo, Odile Kouglenou, Arnaud Agbanlinsou, Georgia Damien, Adolphe Codjo Kpatchavi, Aurel Constant Allabi,
Background: Nonmedical use of tramadol among the young Beninese population is an increasing public health concern. However, there is little research on tramadol use in West Africa.Objectives: This study aimed ... the prevalence, factors associated with nonmedical use of tramadol and to determine the level of therapeutic intervention ... performed using NarcoCheck® quick for qualitative detection of tramadol or its metabolites. Logistic regression analysis was performed to identify factors associated with nonmedical use of tramadol.Results: The average age of our respondents was ...
Tópico(s): Pharmacovigilance and Adverse Drug Reactions
2021 - Taylor & Francis | The American Journal of Drug and Alcohol Abuse
Szabolcs Koncz, Noémi Papp, Noémi Menczelesz, Dóra Pothorszki, György Bagdy,
Tramadol is a widely used, centrally acting, opioid analgesic compound, with additional inhibitory effects on the synaptic ... qEEG) are well characterized; however, such studies of tramadol are scarce. Our aim was to characterize the effects of tramadol on sleep architecture and qEEG in different sleep– ... stages. EEG-equipped Wistar rats were treated with tramadol (0, 5, 15 and 45 mg/kg) at ... and EEG, electromyogram and motor activity were recorded. Tramadol dose-dependently reduced the time spent in rapid ...
Tópico(s): Neuroscience and Neuropharmacology Research
2021 - Multidisciplinary Digital Publishing Institute | Pharmaceuticals
Aysan Khatmi, Mahdi Eskandarian Boroujeni, Samira Ezi, Seyed Hamidreza Mirbehbahani, Fakhroddin Aghajanpour, Reza Soltani, Gholam Hossein Meftahi, Mohammad‐Amin Abdollahifar, Meysam Hassani Moghaddam, Hossein Toreyhi, Fariba Khodagholi, Abbas Aliaghaei,
Tramadol is a synthetic analogue of codeine and stimulates neurodegeneration in several parts of the brain that ... as decreased function of them under influence of tramadol, there are few studies analyzing the effect of tramadol administration on gene expression profiling and structural consequences ... Thus, we sought to determine the effect of tramadol on both PC12 cell line and hippocampal tissue, ... stereological analysis of hippocampus and behavioral assessment following tramadol exposure. At the cellular level, PC12 cells were ...
Tópico(s): Cancer, Stress, Anesthesia, and Immune Response
2021 - Elsevier BV | Neuroscience Letters