Fenella Steyfkens, Zhiqiang Zhang, Griet Van Zeebroeck, Johan M. Thevelein,
... induced during starvation function as transporter-receptors or transceptors for rapid activation of PKA upon re-addition of the missing substrate. In this way, transceptors have been identified for amino acids, ammonium, phosphate, ... hypothesis for regulation of PKA activity by nutrient transceptors to serve as a conceptual framework for future experimentation. Many properties of transceptors appear to be similar to those of classical receptors and nutrient transceptors may constitute intermediate forms in the development of ...
Tópico(s): Plant nutrient uptake and metabolism
2018 - Frontiers Media | Frontiers in Pharmacology
Dieter R. Samyn, Jeroen Van der Veken, Griet Van Zeebroeck, Bengt Persson, Björn C. G. Karlsson,
... MFS) protein, is the main high-affinity Pi transceptor in Saccharomyces cerevisiae. Although transport mechanisms have been ... release of Pi is a critical step for transceptor signaling. Our results add to previous studies on ... the proton-coupled Pi transport cycle of a transceptor. Pho84, a major facilitator superfamily (MFS) protein, is the main high-affinity Pi transceptor in Saccharomyces cerevisiae. Although transport mechanisms have been ... release of Pi is a critical step for transceptor signaling. Our results add to previous studies on ...
Tópico(s): Enzyme Structure and Function
2016 - Elsevier BV | Journal of Biological Chemistry
Harish Nag Kankipati, Marta Rubio‐Texeira, Dries Castermans, George Diallinas, Johan M. Thevelein,
... in favor of Sul1 and Sul2 acting as transceptors for signaling to PKA. First, the sulfate analogue, ... uncoupled from signaling. Overall, our data suggest that transceptors can undergo independent conformational changes, each responsible for triggering different downstream processes. The Sul1 and Sul2 transceptors are the first identified plasma membrane sensors for ... starvation for their substrate may generally act as transceptors during exit from starvation. Sulfate is an essential ... in favor of Sul1 and Sul2 acting as transceptors for signaling to PKA. First, the sulfate analogue, ...
Tópico(s): Nitrogen and Sulfur Effects on Brassica
2015 - Elsevier BV | Journal of Biological Chemistry
Joep Schothorst, Griet Van Zeebroeck, Johan Thevelein,
Multiple types of nutrient transceptors, membrane proteins that combine a transporter and receptor function, have now been established in a variety of organisms. However, so far all established transceptors utilize one of the macronutrients, glucose, amino acids, ... This is also true for the Saccharomyces cerevisiae transceptors mediating activation of the PKA pathway upon re- ... and high-affinity zinc transporter Zrt1 function as transceptors for the micronutrients iron and zinc. We show ... intracellular iron and zinc levels. Similar to the transceptors for macronutrients, Ftr1 and Zrt1 are strongly induced ...
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2017 - Shared Science Publishers OG | Microbial Cell
Grace Armijo, Rodrigo A. Gutiérrez,
... Multiple mechanisms of nitrate sensing by Arabidopsis nitrate transceptor NRT1.1.Nat. Plants. 2015; 1: 15015Crossref PubMed ... was proposed that NRT1.1 functions as a “transceptor,” with dual transport and sensing functions, which is ... Multiple mechanisms of nitrate sensing by Arabidopsis nitrate transceptor NRT1.1.Nat. Plants. 2015; 1: 15015Crossref PubMed ... Multiple mechanisms of nitrate sensing by Arabidopsis nitrate transceptor NRT1.1.Nat. Plants. 2015; 1: 15015Crossref PubMed ... Multiple mechanisms of nitrate sensing by Arabidopsis nitrate transceptor NRT1.1.Nat. Plants. 2015; 1: 15015Crossref PubMed ...
Tópico(s): Pancreatic function and diabetes
2017 - Elsevier BV | Molecular Plant
Y. H. Li, F. N. Li, Li Wu, Y. Y. Liu, Hongkui Wei, T. J. Li, Bie Tan, Xiangfeng Kong, Fei Wu, Yehui Duan, Opeyemi Oladele, Yulong Yin,
... and gene expression profile of selected amino acid transceptors in different fibre type of skeletal muscle tissues ( ... expression levels of sodium‐coupled neutral amino acid transceptor 2, L‐type amino acid transceptor 1 and proton‐assisted amino acid transceptors 2 were higher in skeletal muscle tissue in ... would upregulate the mRNA expression of amino acid transceptors to enhance the absorption of FAA in skeletal ... to be a relationship between response of AA transceptors to the dietary protein level in skeletal muscle ...
Tópico(s): Pharmacological Effects and Assays
2016 - Wiley | Journal of Animal Physiology and Animal Nutrition
Russell Hyde, Emma Cwiklinski, Katrina MacAulay, Peter M. Taylor, Harinder S. Hundal,
... during AA sufficiency, thus echoing AA sensing by transceptor (transporter-receptor) orthologues in yeast (Gap1/Ssy1) and ... during AA sufficiency, thus echoing AA sensing by transceptor (transporter-receptor) orthologues in yeast (Gap1/Ssy1) and ... SNAT2 may function as a hybrid transporter-receptor (transceptor) whereby structural changes during the transport cycle may be transduced to signaling pathways; such AA transceptors are well documented in Saccharomyces cerevisiae (12Donaton M. ... to be verified in mammalian systems. However, this transceptor model cannot completely account for the control of ...
Tópico(s): Protein Kinase Regulation and GTPase Signaling
2007 - Elsevier BV | Journal of Biological Chemistry
Zhiqiang Zhang, Ines Cottignie, Griet Van Zeebroeck, Johan M. Thevelein,
... of their substrate. We now show that these transceptors may play more extended roles in nutrient regulation. ... acid, Mep2 ammonium, Pho84 phosphate and Sul1 sulfate transceptors physically interact in vitro and in vivo with ... the drop in L-citrulline uptake capacity or transceptor activation of the PKA target trehalase by the Gap1 mutant forms. Our results reveal a nutrient transceptor–Sch9–TOR axis in which Sch9 accessibility for phosphorylation by TOR may be affected by nutrient transceptor–Sch9 interaction under conditions of nutrient starvation or ...
Tópico(s): Protein Kinase Regulation and GTPase Signaling
2021 - Portland Press | Biochemical Journal
Deborah C. I. Goberdhan, Clive Wilson, Adrian L. Harris,
... R. Taylor P.M. Hundal H.S. SNAT2 transceptor signalling via mTOR: a role in cell growth ... mTORC1 through direct signaling, acting as so-called "transceptors" (Figure 4A; Goberdhan et al., 2005Goberdhan D.C. ... acid transporter SNAT2 (SLC38A2) may also be a transceptor, since it activates mTORC1 in the presence of ... R. Taylor P.M. Hundal H.S. SNAT2 transceptor signalling via mTOR: a role in cell growth ... R. Taylor P.M. Hundal H.S. SNAT2 transceptor signalling via mTOR: a role in cell growth ... 1299PubMed Google Scholar), SLC38A9 may act as a transceptor because of its close association with the mTORC1 ...
Tópico(s): Polyamine Metabolism and Applications
2016 - Cell Press | Cell Metabolism
Joep Schothorst, Harish Nag Kankipati, Michaela Conrad, Dieter R. Samyn, Griet Van Zeebroeck, Yulia Popova, Marta Rubio‐Texeira, Bengt Persson, Johan M. Thevelein,
... pathway, the latter being mediated by the nutrient transceptors. At the same time, the transceptors are ubiquitinated, endocytosed and sorted to the vacuole ... breakdown. Investigation of the signaling function of the transceptors has provided a new read-out and new ... of nontransported agonists of the signaling function in transceptors has shown that transport is not required for ... Inactivation of transport with maintenance of signaling in transceptors supports that a true proton-binding residue was ...
Tópico(s): Plant Reproductive Biology
2013 - Springer Science+Business Media | Current Genetics
... as ‘sensors’ of changes in mineral nutrient concentrations. Transceptors have been described in yeast, but, until recently, ... Krouk G. Perrine-Walker F. Laugier E. Nitrate transceptor(s) in plants.J. Exp. Bot. 2011; 62: 2299-2308Crossref PubMed Scopus (196) Google Scholar). Transceptor is a term that is used to describe ... The NRT1.1 transporter is the first identified transceptor in plants involved in sensing nutrient concentrations. The ... Krouk G. Perrine-Walker F. Laugier E. Nitrate transceptor(s) in plants.J. Exp. Bot. 2011; 62: ...
Tópico(s): Plant Stress Responses and Tolerance
2012 - Elsevier BV | Molecular Plant
Johan M. Thevelein, Karin Voordeckers,
The discovery of nutrient transceptors, transporter-like proteins with a receptor function, suggests that receptors for chemical signals may have been derived in evolution from ... nutrients as ligands. Recent results have revealed that transceptor signaling requires a specific ligand-induced conformational change, which indicates that transceptors function in a similar way as regular receptors. ... in distantly related proteins identifies the nontransporting glucose transceptor Rgt2 as the closest homologue of the glucose- ...
Tópico(s): Microbial Metabolic Engineering and Bioproduction
2009 - Oxford University Press | Molecular Biology and Evolution
Bert van den Berg, Siobhan Lister, Julian C. Rutherford,
Transceptors are nutrient transporters that act as receptors to regulate downstream signaling pathways. Ammonium transceptors regulate fungal morphology in response to limiting levels ... Few studies have addressed to what extent ammonium transceptors are conserved in pathogenic fungi. Plant and animal ... widespread studies are needed to determine if ammonium transceptors have a general role in regulating the virulence ...
Tópico(s): Plant-Microbe Interactions and Immunity
2019 - Public Library of Science | PLoS Pathogens
Elizabeth A. Znameroski, Xin Li, Jordan C. Tsai, Jonathan M. Galazka, N. Louise Glass, Jamie H. D. Cate,
... that the N. crassa cellodextrin transporters act as "transceptors" with dual functions - cellodextrin transport and receptor signaling ... activation of cellulolytic gene expression. Similar mechanisms of transceptor activity likely occur in related ascomycetes used for ... that the N. crassa cellodextrin transporters act as "transceptors" with dual functions - cellodextrin transport and receptor signaling ... activation of cellulolytic gene expression. Similar mechanisms of transceptor activity likely occur in related ascomycetes used for ...
Tópico(s): Plant-Microbe Interactions and Immunity
2013 - Elsevier BV | Journal of Biological Chemistry
Griet Van Zeebroeck, Marlies Kimpe, Patrick Vandormael, Johan M. Thevelein,
... a transport and receptor function, and are called transceptors. The Gap1 general amino acid permease and the ... strains, clearly separating the two functions of the transceptors and confirming that signaling does not require transport. ... complex trafficking control of the Gap1 and Mep2 transceptors.
Tópico(s): Plant nutrient uptake and metabolism
2011 - Public Library of Science | PLoS ONE
Harinder S. Hundal, Peter M. Taylor,
... of dual-function amino acid transporter/receptor (or “transceptor”) proteins is well established in primitive eukaryotes such ... lines have revealed perhaps unanticipated “echoes” of these transceptor functions, which are revealed by cellular stresses (notably ... by extrapolation from knowledge of the yeast Ssy1 transceptor) that, at least for SNAT2, the transceptor discriminates between extracellular and intracellular amino acid stimuli ...
Tópico(s): Amino Acid Enzymes and Metabolism
2009 - American Physiological Society | AJP Endocrinology and Metabolism
... newcomer in environment sensing are the so called transceptors, membrane proteins that possess both solute transport and receptor-like signaling activities. Now, the transceptor concept is further enlarged to include micronutrient sensing ... and/or sensing function of receptors, transporters and transceptors is ligand-induced conformational alterations recognized by downstream ...
Tópico(s): Photosynthetic Processes and Mechanisms
2017 - Shared Science Publishers OG | Microbial Cell
Alaín Gojon, Gabriel Krouk, Francine Perrine‐Walker, Edith Laugier,
... described in yeast and animals, and are called 'transceptors'. This review aims to illustrate the nutrient transceptor concept in plants by presenting the current evidence ... considered, and the possible occurrence of other nitrate transceptors is discussed.
Tópico(s): Legume Nitrogen Fixing Symbiosis
2011 - Oxford University Press | Journal of Experimental Botany
Johan Kriel, Steven Haesendonckx, Marta Rubio‐Texeira, Griet Van Zeebroeck, Johan M. Thevelein,
... of these transporters also act as receptors, or transceptors, suggests that at least part of the sophisticated ... are subject to amino acid control. Other nutrient transceptors controlling this signal transduction pathway appear to be ... control have also been suggested to function as transceptors in other organisms. Hence, precise regulation of intracellular ...
Tópico(s): Biotin and Related Studies
2011 - Wiley | BioEssays
Yulia Popova, Thayumanavan Palvannan, Elena Lonati, Margarida Agrochão, Johan M. Thevelein,
... as nutrient sensors. The action mechanism of these "transceptors" is unclear. The Pho84 phosphate transceptor in yeast transports phosphate and mediates rapid phosphate ... insight into the molecular mechanism of a phosphate transceptor.
Tópico(s): Plant nutrient uptake and metabolism
2010 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Xiaohan Wang, Changxin Feng, Lili Tian, Congcong Hou, Wang Tian, Bin Hu, Qian Zhang, Zhijie Ren, Qi Niu, Jiali Song, Dongdong Kong, Liangyu Liu, Yikun He, Ligeng Ma, Chengcai Chu, Sheng Luan, Legong Li,
... gated channel (CNGC) protein, CNGC15, and the nitrate transceptor (NRT1.1) constitute a molecular switch that controls ... new nutrient-sensing mechanism that utilizes a nutrient transceptor–channel complex assembly to couple nutrient status to ...
Tópico(s): Plant Stress Responses and Tolerance
2021 - Elsevier BV | Molecular Plant
Amel Maghiaoui, Eléonore Bouguyon, Candela Cuesta, Francine Perrine‐Walker, Carine Alcon, Gabriel Krouk, Eva Benková, Philippe Nacry, Alaín Gojon, Liên Bach,
... stress responses. In Arabidopsis, the NRT1.1 nitrate transceptor represses lateral root (LR) development at low nitrate ... Altogether, our results indicate that the NRT1.1 transceptor coordinately controls several crucial auxin-associated processes required ...
Tópico(s): Plant tissue culture and regeneration
2020 - Oxford University Press | Journal of Experimental Botany
Shih‐Jung Fan, Deborah C. I. Goberdhan,
... as amino acid-stimulated receptors, or so-called "transceptors," connecting amino acids to mTORC1 activation. Since then, ... homology within their transmembrane domains, can act as transceptors. A paradigm shift has also led to the ... PAT and SNAT amino acid sensors, including the transceptor mechanism, have implications for the pharmacological inhibition of ...
Tópico(s): Receptor Mechanisms and Signaling
2018 - Frontiers Media | Frontiers in Pharmacology
Xianan Xie, Hui Lin, Xiao-Wei PENG, Congrui Xu, Zhongfeng Sun, Kexin Jiang, Antian Huang, Xiaohui Wu, Nianwu Tang, Alessandra Salvioli, Paola Bonfante, Bin Zhao,
... symbiosis. Most importantly, GigmPT functions as a phosphate transceptor in G. margarita regarding the activation of the ... insights into the molecular functions of a phosphate transceptor from the AM fungus G. margarita.
Tópico(s): Legume Nitrogen Fixing Symbiosis
2016 - Elsevier BV | Molecular Plant
Peter Poulsen, Per Amstrup Pedersen,
... we examined the production of a human glucose transceptor and 11 nutrient transporters and transceptors from S. cerevisiae that have not previously been ...
Tópico(s): Glycosylation and Glycoproteins Research
2013 - Public Library of Science | PLoS ONE
Dieter R. Samyn, Lorena Ruiz‐Pavón, Michael R. Andersson, Yulia Popova, Johan M. Thevelein, Bengt Persson,
... features led to recognition of Pho84 as a transceptor. Although the physiological role of Pho84 has been ... to separate the transport and signalling functions in transceptors.
Tópico(s): Genomics and Chromatin Dynamics
2012 - Portland Press | Biochemical Journal
Marta Rubio‐Texeira, Griet Van Zeebroeck, Karin Voordeckers, Johan M. Thevelein,
... transduction in association with a G protein; nontransporting transceptors, i.e. nutrient carrier homologues with only a receptor function, previously called nutrient sensors; and transporting transceptors, i.e. active nutrient carriers that combine the ... known examples of the second category, the nontransporting transceptors, which control the expression of the regular transporters ...
Tópico(s): Polyamine Metabolism and Applications
2009 - Oxford University Press | FEMS Yeast Research
Johan M. Thevelein, Beatriz M. Bonini, Dries Castermans, Steven Haesendonckx, Johan Kriel, Wendy Louwet, Thayumanavan Palvannan, Yulia Popova, Marta Rubio‐Texeira, Wim Schepers, Patrick Vandormael, Griet Van Zeebroeck, Peter Verhaert, Matthias Versele, Karin Voordeckers,
... messenger. Amino acids are sensed by the Gap1 transceptor, previously considered only as an amino acid transporter. ... been obtained for Pho84 which acts as a transceptor for phosphate activation of the PKA pathway. Ammonium ... starved cells is mediated mainly by the Mep2 transceptor, which belongs to a different class of transporter ...
Tópico(s): Protein Kinase Regulation and GTPase Signaling
2008 - Akadémiai Kiadó | Acta Microbiologica et Immunologica Hungarica
Yuanyuan Wang, Jia Zhou, Yun Zou, Xiaoqing Chen, Lin Liu, Wanjun Qi, Xinhua Huang, Changbin Chen, Ning-Ning Liu,
... Here, we discover that depletion of the phosphate transceptor Pho84 across multiple fungal species encountered a substantial ...
Tópico(s): Fungal Biology and Applications
2022 - Cell Press | Cell Reports
Shuang Li, Yuanyuan Li, Blake R. Rushing, Sarah E. Harris, Susan McRitchie, Daniel Domínguez, Susan Sumner, Henrik Dohlman,
... first is a heterodimer of transporter-like proteins (transceptors), while the second is a seven-transmembrane receptor ... receptor directs carbohydrate and energy metabolism, while the transceptors regulate ancillary processes such as ribosome, amino acids, ...
Tópico(s): Bioinformatics and Genomic Networks
2022 - Multidisciplinary Digital Publishing Institute | Biomolecules