Ramón Bover, Francisco Pérez-Gómez, María P. Maluenda, Susana Asenjo, Rosario Pérez-Saldaña, Ángel Igea, Marta Suárez, Dulcenombre Coleto, Cristina Fernández,
... la anticoagulación (INR 1,9-2,5) más triflusal 600 mg/día, triflusal 300 mg/día o ácido acetilsalicílico 100 mg/ ... el beneficio significativo del tratamiento combinado anticoagulante más triflusal 600 mg/día frente a la anticoagulación sola ( ... tasa de accidentes isquémicos durante el uso de triflusal 300 mg/día (p = 0,031) y de ... no gástricas severas durante el tratamiento combinado con triflusal fue muy baja (0,3% pacientes/año). El ... confirmado el beneficio del tratamiento antitrombótico combinado con triflusal 600 mg/día frente a la monoterapia anticoagulante. ...
Tópico(s): Venous Thromboembolism Diagnosis and Management
2009 - Elsevier BV | Revista Española de Cardiología
Ramón Bover, Francisco Pérez-Gómez, María P. Maluenda, Susana Asenjo, Rosario Pérez-Saldaña, Ángel Igea, Marta Magdalena Suárez, Dulcenombre Coleto, Cristina Fernández,
... anticoagulation (INR, 1.9-2.5) plus either triflusal at 600 mg/d, triflusal at 300 mg/d, or aspirin at 100 ... confirmed that combination therapy with an anticoagulant plus triflusal at 600 mg/day gave significantly better results ... a significantly higher incidence of ischemic events with triflusal at 300 mg/day (P=.031) and of ... of severe nongastric bleeding during combination therapy with triflusal was very low (0.3% of patients/year). ... follow-up confirmed that combination antithrombotic therapy with triflusal at 600 mg/d gave significantly better results ...
Tópico(s): Acute Ischemic Stroke Management
2009 - Elsevier BV | Revista Española de Cardiología (English Edition)
Jordi A. Matías‐Guiu, José M. Ferro, José Álvarez‐Sabín, Ferrán Torres, MD Jimenez, Aída Lago, Teresa Pinho e Melo,
... and Purpose— The efficacy of the antiplatelet agent triflusal for prevention of vascular events after stroke has ... blind, multicenter study to test the efficacy of triflusal (600 mg/d) versus aspirin (325 mg/d) ... in patients with stroke or transient ischemic attack (Triflusal versus Aspirin in Cerebral Infarction Prevention [TACIP]). We ... major hemorrhage. Results— Of 2113 patients, 1058 received triflusal and 1055 aspirin. The mean follow-up period ... incidence of combined end point (13.1% for triflusal, 12.4% for aspirin) as well the survival ...
Tópico(s): Venous Thromboembolism Diagnosis and Management
2003 - Lippincott Williams & Wilkins | Stroke
Graeme J. Hankey, João Costa, José M. Ferro, Jordi A. Matías‐Guiu, José Álvarez‐Sabín, Ferrán Torres,
... other vascular events. Because several studies suggested that triflusal (an antiplatelet agent structurally related to aspirin) may ... performed a Cochrane systematic review to determine whether triflusal is an effective and safe treatment for primary ... for analysis randomized and quasi-randomized studies comparing triflusal with placebo or aspirin in people at high ... the primary outcome there was no difference between triflusal and aspirin. Triflusal was associated with a lower frequency of hemorrhages ( ...
Tópico(s): Stroke Rehabilitation and Recovery
2006 - Lippincott Williams & Wilkins | Stroke
José I. Aramendi, Carlos-Alfonso Mestres, Juan Martínez-León, Vicente Campos, Genı́s Muñoz, Carlos A. Navas,
... was to compare the efficacy and safety of triflusal (an antiplatelet agent) versus acenocoumarol for primary prevention ... pilot trial, patients were assigned to treatment with triflusal (600mg/d) or acenocoumarol (target INR 2.0– ... total of 193 patients were included (97 received triflusal and 96 acenocoumarol), with a mean age of ... Primary outcome was recorded in 9 patients with triflusal (9.4%) and in 10 patients with acenocoumarol ( ... episodes (4.7%) of thromboembolism, six in the triflusal group and three in the acenocoumarol group, and ...
Tópico(s): Antiplatelet Therapy and Cardiovascular Diseases
2005 - Oxford University Press | European Journal of Cardio-Thoracic Surgery
João Costa, José M. Ferro, Jordi A. Matías‐Guiu, José Álvarez‐Sabín, Ferrán Torres,
... and other vascular events. Several studies suggest that triflusal may have a better safety profile. Objectives To ... people at high risk of vascular events whether triflusal is an effective and safe treatment for primary ... Selection criteria Randomised and quasi‐randomised studies comparing triflusal with placebo or aspirin in people at high ... and major hemorrhages. Main results (1) Aspirin versus triflusal: five studies enrolled patients with stroke or transient ... vascular event there was no significant difference between triflusal and aspirin; the odds ratio (OR) was 1. ...
Tópico(s): Venous Thromboembolism Diagnosis and Management
2005 - Elsevier BV | Cochrane library
Antonio Culebras, R Rotta-Escalante, José F. Vila, Raúl Domínguez, G. Abiusi, A. Famulari, R. Rey, L. Bauso–Tosselli, H Gori, Julia Ferrari, E. Reich,
Triflusal is an antiplatelet agent that has shown clinical advantages when compared with aspirin in the secondary prevention of vascular events. TAPIRSS (Triflusal versus Aspirin for Prevention of Infarction: a Randomized Stroke Study) explored the efficacy and safety of triflusal in the secondary prevention of stroke in a ... randomized to receive aspirin 325 mg daily or triflusal 600 mg daily for a mean of 586 ... myocardial infarction, or major hemorrhage (aspirin 13.9%, triflusal 12.7%; odds ratio [OR] 1.11, 95% ...
Tópico(s): Venous Thromboembolism Diagnosis and Management
2004 - Lippincott Williams & Wilkins | Neurology
José Álvarez‐Sabín, Manuel Quintana, Estevo Santamarina, Olga Maisterra,
... We have assessed the safety and effectiveness of triflusal and aspirin for a very long-term period ... TIA, who participated in randomized clinical trials of triflusal versus aspirin were included in the study. The ... hospital. All patients were treated with aspirin or triflusal during a mean period of 17.2 years. ... study; 288 patients (65.3%) were treated with triflusal and 153 with aspirin. There were no statistically significant differences between aspirin and triflusal concerning new vascular events (72.5 vs. 60. ...
Tópico(s): Cerebrovascular and Carotid Artery Diseases
2014 - Karger Publishers | Cerebrovascular Diseases
Antonio Culebras, R Rotta-Escalante, Joan Vila, Raúl Domínguez, G. Abiusi, A. Famulari, R. Hernández del Rey, L Bauso-Toselli, H Gori, Julia Ferrari, H. Fraiman,
... pilot trial designed to study the efficacy of triflusal for the prevention of secondary ischemic stroke conducted in Buenos Aires, Argentina. Triflusal is an antiplatelet agent structurally related to aspirin. ... aspirin therapy, 325 mg/daily) or group #2 (triflusal, 600 mg/daily). All patients had experienced either ... endpoints showed no significant differences between aspirin and triflusal. Aggregate analysis of secondary enpoints showed a significant difference in favor of triflusal [p=0.038]. Analysis of the combination severe ...
Tópico(s): Neurological Disorders and Treatments
2001 - Lippincott Williams & Wilkins | Stroke
Srinivasulu Aitipamula, Lucy K. Mapp, Annie B. H. Wong, Pui Shan Chow, Reginald B. H. Tan,
A platelet aggregation inhibitor, triflusal, is practically insoluble in water and rapidly converts to 2-hydroxy-4-trifluoromethylbenzoic acid (HTB) in physiological systems. Six cocrystals of triflusal were discovered from a cocrystal screening with pharmaceutically ... an attempt to find stable solid forms of triflusal. The choice of coformers was based on a ... relying on the carboxylic acid group of the triflusal and the most prevalent supramolecular interactions that it ... cocrystals feature heterosynthons involving carboxylic acid group of triflusal and pyridine/amide group of the coformers. Except ...
Tópico(s): Energetic Materials and Combustion
2015 - Royal Society of Chemistry | CrystEngComm
Alberto Fernández de Arriba, Fernando Cavalcanti, Ana Miralles-Marco, Yolanda Bayón, Andrés Alonso, Manuel Merlos, Julián Garcı́a-Rafanell, J Forn,
... salicylate derivatives [2-acetoxy-4-trifluoromethyl-benzoic acid (triflusal) and its deacetylated metabolite 2-hydroxy-4-trifluoromethylbenzoic ... observed that in bacterial lipopolysaccharide-activated human blood, triflusal, aspirin, and HTB, but not sodium salicylate, inhibited ... 0.39, and >10 mM, respectively). However, only triflusal and aspirin inhibited purified COX-2 enzyme. To ... this apparent discrepancy, we realized that HTB and triflusal (but neither aspirin nor salicylate) produced a concentration- ...
Tópico(s): Cytokine Signaling Pathways and Interactions
1999 - American Society for Pharmacology and Experimental Therapeutics | Molecular Pharmacology
Zareen Amtul, Wasimul Haque, David F. Cechetto,
... dependent effect of combination therapy with dipyridamole and triflusal over that of triflusal alone on infarct size after middle cerebral artery ... permanent MCAO in the right hemisphere. Rats received triflusal alone and with dipyridamole via oral route. Three ... volumes were measured.The lower dose regime of triflusal (10 mg/kg) and dipyridamole (200 mg/kg) ... infarct size compared with higher dose regime of triflusal (30 mg/kg) and dipyridamole (200 mg/kg) (P <.01), triflusal (30 mg/kg) alone (P <.07), and vehicle- ...
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2018 - Elsevier BV | Journal of Stroke and Cerebrovascular Diseases
Shawn N. Whitehead, Nestor A. Bayona, Guanliang Cheng, Gary V. Allen, Vladimir Hachinski, David F. Cechetto,
... critical role in the pathogenesis of cerebral ischemia. Triflusal, a selective cyclooxygenase-2, and its active metabolite ... ischemia was used to investigate the effects of triflusal and aspirin treatment on infarct volume, and inflammation ... artery occlusion. Rats received oral administration of either triflusal or aspirin. After 3 days after surgery, immunostaining ... molecules, and infarct volumes were measured. Results— Both triflusal and aspirin at a dose of 30 mg/ ... protein-27 (Hsp27) immunostaining in the ipsilateral cortex. Triflusal (30 mg/kg) or aspirin treatment (30 mg/ ...
Tópico(s): Biochemical effects in animals
2006 - Lippincott Williams & Wilkins | Stroke
Enrico Ferrari, Gianpaolo Reboldi, Patrice Marenco, Luca D’Angelo, Francesca Crema, L. Ambrosoli, Anicleto Poli, R. Girardello, David Löwenthal,
... single-dose and steady-state pharmacokinetics of unchanged triflusal and its metabolite 2-hydroxy-4-trifluoromethylbenzoic acid ( ... with a single oral administration of 300 mg triflusal and repeated oral administrations of 300 mg triflusal b.i.d. for 13 days. After a single administration, unchanged triflusal is promptly absorbed (t(max) 0.75 h, ... h. HTB proves to be quickly generated from triflusal (t(max) 2.00 h, C(max) 39. ... 6 h). With the dose regimen proposed, unchanged triflusal does not accumulate in the body. Conversely, HTB ...
Tópico(s): Temporomandibular Joint Disorders
1996 - Lippincott Williams & Wilkins | American Journal of Therapeutics
... the efficacy and tolerability of the antiplatelet agent triflusal with aspirin in the prevention of cardiovascular events ... of acute myocardial infarction symptom onset to receive triflusal 600 mg or aspirin 300 mg once daily ... fatal cerebrovascular events were significantly less frequent with triflusal (OR [95% CI]: 0.364 [0.146-0. ... was a trend towards fewer bleeding episodes with triflusal; significantly fewer central nervous system bleeding episodes were observed in triflusal-treated patients (0.27% vs. 0.97%; P = ...
Tópico(s): Acute Myocardial Infarction Research
2000 - Oxford University Press | European Heart Journal
José Antonio González Correa, M.M. Arrebola, Issamar Urena, A. Guerrero, Javier Muñoz-Marín, D. Ruiz‐Villafranca, Felipe Sánchez de la Cuesta, J.P. De La Cruz,
... study was to evaluate the neuroprotective effect of triflusal, a fluorinated derivative of ASA, in a model ... or 50 mg/kg/day p.o. of triflusal or ASA or solvent (control group), then brain ... activity) and cell death (lactate dehydrogenase (LDH) efflux). Triflusal decreased cell death in rat brain slices subjected ... 0%, 25% and 24%). The antioxidant effects of triflusal on the biochemical mechanisms of cell damage studied ... was reduced by 29%, 35% and 36% with triflusal, and 0%, 19% and 29% with ASA. Inducible ...
Tópico(s): Cardiac Ischemia and Reperfusion
2004 - Elsevier BV | Brain Research
Laia Acarín, Berta González, Bernardo Castellano,
... In this study we evaluate the ability of triflusal (2-acetoxy-4-trifluoromethylbenzoic acid), an antiplatelet agent ... methyl- d -aspartate (NMDA) and oral administration of triflusal (30 mg/kg) either as 3 doses before ... NMDA-lesioned animals that were not treated with triflusal showed activation of NF-κB in neuronal cells ... glial cells subsequently. Animals that received pretreatment with triflusal showed a strong downregulation of neuronal and glial ... compared with nontreated animals. In contrast, animals receiving triflusal posttreatment showed increased early neuronal NF-κB but ...
Tópico(s): Neonatal and fetal brain pathology
2001 - Lippincott Williams & Wilkins | Stroke
Lourdes Sánchez de Miguel, Santos Casado, Jerónimo Farré, Margarita Garcı́a-Durán, Luís Rico, Mercedes Montón, José R. Romero, Teresa Bellver, María P. Sierra, José I. Guerra, Pedro Mata, Martin Dres, Antonio López‐Farré,
... platelet antiaggregating drug, 2-acetoxy-4-trifluoromethylbenzoic acid (triflusal) and of acetylsalicylic acid on the interaction between ... capability of neutrophils to generate nitric oxide (NO). Triflusal, in the presence of neutrophils, showed a greater ... mechanisms in the presence of acetylsalicylic acid or triflusal was demonstrated by the following findings: (1) increased ... l-NAME), which was reversed by l-Arg. Triflusal increased the stimulation of NO synthesis by neutrophils ... did of acetylsalicylic acid. The main metabolite of triflusal, 2-hydroxy-4-trifluoromethylbenzoic acid (HTB), alone or ...
Tópico(s): Receptor Mechanisms and Signaling
1998 - Elsevier BV | European Journal of Pharmacology
Maria Montero Domínguez, Berta González, Jens Zimmer,
... 3) OGD cultures; (4) OGD cultures treated with triflusal during OGD; (5) microglia-depleted control cultures; (6) ... and (8) microglia-depleted OGD cultures treated with triflusal during OGD. The resulting neurodegeneration was quantified by ... to control cultures. The presence of 100 microM triflusal during OGD protected against OGD-induced neurodegeneration, and ... compared to non-depleted cultures. The presence of triflusal during OGD of these cultures reduced neurodegeneration of ... microglia. In accordance with that, the presence of triflusal during OGD significantly inhibited the increase in the ...
Tópico(s): Neurological Disease Mechanisms and Treatments
2009 - Elsevier BV | Experimental Neurology
Teresa Gómez‐Isla, Rafael Blesa, Merçé Boada, Jordi Clarimón, Teodoro del Ser, Gemma Domènech, José M. Ferro, Beatriz Gómez‐Ansón, J.M. Manubens, J. M. Martínez‐Lage, David G. Muñoz, Jordi Peña‐Casanova, Ferrán Torres,
... Alzheimer disease. In vivo studies have shown that Triflusal and its active metabolite 2-hydroxy-4-trifluoromethyl- ... a randomized, double-blind, placebo-controlled trial of Triflusal in patients with amnestic mild cognitive impairment. Subjects were randomly assigned to receive 900 mg of Triflusal or placebo for 18 months. The primary outcome ... outcome even though a trend in favor of Triflusal was observed. However, there was a significant difference ... s type with a lower risk in the Triflusal compared with the placebo group (hazard ratio, 2. ...
Tópico(s): Neurological Disorders and Treatments
2008 - Lippincott Williams & Wilkins | Alzheimer Disease & Associated Disorders
L. Plaza, L. L oacute pez-Besc oacute s, L.M. Mart iacute n-Jadraque, E. Alegrla, J.M. Cruz-Fern aacute ndez, José Ignácio Velasco, J.A. Ruip eacute rez, F Malpartida, A. Artal, A. Cabad eacute s, A.F. Zurita,
... evaluate the effect of a new antiplatelet agent, triflusal (2-acetoxy-4-trifluoromethyl benzoic acid), in the ... unstable angina. 281 patients were randomly assigned to triflusal (300 mg t.i.d.; n = 143) or ... acute myocardial infarction was significantly lower in the triflusal than in the placebo group: 6 patients (4. ... 013. The low number of deaths (2/143 triflusal versus 0/138 placebo recipients) hampered statistical analysis ... two groups: 24 patients (16.8%) in the triflusal group and 28 (20.3%) in the placebo ...
Tópico(s): Cerebrovascular and Carotid Artery Diseases
1993 - Karger Publishers | Cardiology
de Miguel, Jiménez, Montón, Farré, Del Mar Arriero, Rodríguez‐Feo, García‐Cañete, Rico, Gómez, Núñez, Casadó, Farré,
... studies performed in our laboratory have demonstrated that triflusal, a 4‐trifluoromethyl derivative of salicylate, reduced platelet ... evaluate whether oral treatment of healthy volunteers with triflusal could modify the ability of their neutrophils to ... 12 healthy volunteers who were orally treated with triflusal (600 mg day −1 ) for 5 days. Flow ... of their α‐granules. Results After treatment with triflusal, there was an increase in NO production by ... expression. Conclusion Oral treatment of healthy volunteers with triflusal stimulated NO production and eNOS protein expression in ...
Tópico(s): Antiplatelet Therapy and Cardiovascular Diseases
2000 - Wiley | European Journal of Clinical Investigation
N. Heye, Aline Gomes de Campos, Seiji Kannuki, Jorge Cervós‐Navarro,
... tested the effect of acetylsalicylic acid (ASA) and triflusal (2-acetoxy-4-tri-fluoromethylbenzonic acid) on the ... consisting of six animals received either ASA or triflusal at dosages of 12.5, 25 or 50 ... in the group treated with 12.5 mg triflusal (mean 5.2). No statistic significant difference in ... between the groups treated with 12.5 mg triflusal and 50 mg ASA (mean 8.7) compared ... p>0.05). Treatment with 12.5 mg triflusal was superior to 50 mg ASA in preventing ...
Tópico(s): Electrospun Nanofibers in Biomedical Applications
1991 - Elsevier BV | Experimental Pathology
Laia Acarín, Berta González, Bernardo Castellano,
Background and Purpose— The fluorinated salicylate triflusal has been shown to have a neuroprotective effect after an excitotoxic lesion to the postnatal brain. In this regard, the aim of ... methyl- d -aspartate followed by oral administration of triflusal (30 mg/kg) 8 hours later. Ten or ... Results— Besides a reduction in the neurodegenerative area, triflusal strongly decreased iNOS immunolabeling at both survival times ... 2, IL-1β, and TNF-α was observed. Triflusal decreased neuronal and microglial COX-2 expression at ...
Tópico(s): Anesthesia and Neurotoxicity Research
2002 - Lippincott Williams & Wilkins | Stroke
Hea‐Young Cho, Tae-Jin Jeong, Yong‐Bok Lee,
... developed and validated for the simultaneous determination of triflusal and its major active metabolite, 2-hydroxy-4- ... human plasma was 93.5±4.2% for triflusal and 98.5±3.1% for HTB. The lower limits of quantification of triflusal and HTB in human plasma were 20 and ... range 0.02–5.0 μg/ml for triflusal and 0.1–200.0 μg/ml for ... applied to the study of metabolite pharmacokinetics of triflusal and HTB in rat and human.
Tópico(s): Radical Photochemical Reactions
2003 - Elsevier BV | Journal of Chromatography B
J. Fraj, Antonio Valero, R. Vives, Inmaculada Sánchez Pérez, Javier Borja, Iñaki Izquierdo, César Picado,
... but not COX-2 inhibitors precipitate asthma attacks. Triflusal is a preferential COX-2 inhibitor antiplatelet agent ... the study was to assess the tolerability of triflusal in patients with aspirin-exacerbated respiratory disease (AERD). ... placebo-controlled oral challenge with three doses of triflusal separated by 1 week (first cumulative dose = 225 ... 24 h at home.No clinical reactions to triflusal were observed. There were no significant changes in ... function measurements.Our study appears to demonstrate that triflusal is a suitable alternative to aspirin as antiplatelet ...
Tópico(s): Atrial Fibrillation Management and Outcomes
2007 - Wiley | Allergy
Anna Argemí, Ana M. López‐Periago, Concepción Domingo, Javier Saurina,
... of an analytical method for the characterization of triflusal (2-acetoxy-4-(trifluoromethyl) benzoic acid) dispersed in ... assays comprised the determination of the percentage of triflusal and its degradation product impregnated in polymeric supports ... this case, no selective wavelength for discriminating between triflusal and metabolite was found so that measurements at ... of the concentration of the two components independently. Triflusal and metabolite were separated in a C18 column ... methanol (40/60 v/v) mobile phase. Several triflusal-polymer samples were prepared under different experimental conditions ...
Tópico(s): Innovative Microfluidic and Catalytic Techniques Innovation
2007 - Elsevier BV | Journal of Pharmaceutical and Biomedical Analysis
Jordi A. Matías‐Guiu, José M. Ferro, José Álvarez‐Sabín, Ferran Torres,
... parallel trial comparing the efficacy and safety of triflusal (600 mg/od) and ASA (325 mg/od) ... minor hemorrhages were higher in ASA than in triflusal group (24.5% vs 16.4%; p Conclusion: Triflusal and low-dose ASA have a similar efficacy ... Major and minor hemorrhages were significantly reduced by triflusal. Triflusal is a safer alternative to aspirin in the ...
Tópico(s): Atrial Fibrillation Management and Outcomes
2001 - Lippincott Williams & Wilkins | Stroke
Jordi A. Matías‐Guiu, José M. Ferro, José Álvarez‐Sabín, Ferrán Torres,
... parallel trial comparing the efficacy and safety of triflusal (600 mg/od) and ASA (325 mg/od) ... minor hemorrhages were higher in ASA than in triflusal group (24.5% vs 16.4%; p<0.001). Conclusion: Triflusal and low-dose ASA have a similar efficacy ... Major and minor hemorrhages were significantly reduced by triflusal. Triflusal is a safer alternative to aspirin in the ...
Tópico(s): Atrial Fibrillation Management and Outcomes
2001 - Lippincott Williams & Wilkins | Stroke
C.J. Little, A.D. Dale, J. A. Whatley, J.A. Wickings,
... developed and validated for the simultaneous determination of triflusal and its major active metabolite, 2-hydroxy-4- ... human plasma was 93.5±4.2% for triflusal and 98.5±3.1% for HTB. The lower limits of quantification of triflusal and HTB in human plasma were 20 and ... range 0.02–5.0 μg/ml for triflusal and 0.1–200.0 μg/ml for ... applied to the study of metabolite pharmacokinetics of triflusal and HTB in rat and human.
Tópico(s): Analytical Chemistry and Chromatography
1979 - Elsevier BV | Journal of Chromatography A