Hans-Ulrich Schlüter, Gerhard Best, Udo Jürgens, Franz Binot,
Tópico(s): Geological and Geophysical Studies
1997 - Deutsche Geologische Gesellschaft – Geologische Vereinigung | Zeitschrift der Deutschen Geologischen Gesellschaft
Andre Pittig, Ingmar Heinig, Stephan Goerigk, Freya Thiel, Katrin Hummel, Lucie Scholl, Jürgen Deckert, Paul Pauli, Katharina Domschke, Ulrike Lueken, Thomas Fydrich, Lydia Fehm, Jens Plag, Andreas Ströhle, Tilo Kircher, Benjamin Straube, Winfried Rief, Katja Koelkebeck, Volker Arolt, Udo Dannlowski, Jürgen Margraf, Christina Totzeck, Silvia Schneider, Peter Neudeck, Michelle G. Craske, Maike Hollandt, Jan Richter, Alfons O. Hamm, Hans‐Ulrich Wïttchen,
Background The need to optimize exposure treatments for anxiety disorders may be addressed by temporally intensified exposure sessions. Effects on symptom reduction and public health benefits should be examined across different anxiety disorders with comorbid conditions. Methods This multicenter randomized controlled trial compared two variants of prediction error-based exposure therapy (PeEx) in various anxiety disorders (both 12 sessions + 2 booster sessions, 100 min/session): temporally intensified ...
Tópico(s): Child and Adolescent Psychosocial and Emotional Development
2021 - Wiley | Depression and Anxiety
Heinrich Koertke, Armin Zittermann, Otto Wagner, Songuel Secer, Alfonso Sciangula, W. Saggau, Falk‐Udo Sack, Jürgen Ennker, Jochen Cremer, Francesco Musumeci, Jan Gummert,
To study in patients performing international normalized ratio (INR) self-control the efficacy and safety of an INR target range of 1.6–2.1 for aortic valve replacement (AVR) and 2.0–2.5 for mitral valve replacement (MVR) or double valve replacement (DVR). In total, 1304 patients undergoing AVR, 189 undergoing MVR and 78 undergoing DVR were randomly assigned to low-dose INR self-control (LOW group) (INR target range, AVR: 1.8–2.8; MVR/DVR: 2.5–3.5) or very low-dose INR self-control once a week (VLO group) ...
Tópico(s): Cardiac pacing and defibrillation studies
2014 - Oxford University Press | European Heart Journal
Lutz Ehlkes, Anne Caroline Krefis, Benno Kreuels, Ralf Krumkamp, Ohene Adjei, Matilda Ayim-Akonor, Robin Kobbe, Andreas Hahn, Christof D. Vinnemeier, Wibke Loag, Udo Schickhoff, Jürgen May,
Malaria is a mosquito-borne parasitic disease that causes severe mortality and morbidity, particularly in Sub-Saharan Africa. As the vectors predominantly bite between dusk and dawn, risk of infection is determined by the abundance of P. falciparum infected mosquitoes in the surroundings of the households. Remote sensing is commonly employed to detect associations between land use/land cover (LULC) and mosquito-borne diseases. Due to challenges in LULC identification and the fact that LULC merely ...
Tópico(s): Insect Pest Control Strategies
2014 - BioMed Central | International Journal of Health Geographics
Michael Müller, Yvonne Oelmann, Udo Schickhoff, Jürgen Böhner, Thomas Scholten,
Only a few studies have addressed the soil and foliar carbon:nitrogen:phosphorus (C:N:P) stoichiometry in alpine treeline ecotones. Moreover, information on the soil nutrient availability (primarily N, P) in such ecosystems is rare. To fill these gaps, we performed a multiple data sampling in a near-natural alpine treeline ecotone in Rolwaling Himal, Nepal. Our results show strongly varying soil C:N:P ratios and nutrient availability with soil depth. Caused by high monsoon precipitation and coarse- ...
Tópico(s): Cryospheric studies and observations
2017 - Elsevier BV | Geoderma
Stanley U. Okoro, Udo Schickhoff, Jürgen Böhner, Uwe A. Schneider, Neil Huth,
Palm oil production has increased in recent decades and is estimated to increase further globally. The optimal role of palm oil production, however, is controversial because of conflicts with other important land uses and ecosystem services. Local conditions and climate change affect resource competition and the desirability of palm oil production in the Niger Delta, Nigeria. The objectives of this study are to (1) establish a better understanding of the existing yield potentials of oil palm areas ...
Tópico(s): Agriculture Sustainability and Environmental Impact
2017 - Elsevier BV | European Journal of Agronomy
Michael Müller, Niels Schwab, Udo Schickhoff, Jürgen Böhner, Thomas Scholten,
Soil properties in alpine treeline ecotones are insufficiently explored. In particular, an extensive monitoring of soil moisture conditions over a longer period of time is rare, and the effects of soil moisture variability on alpine treelines have not received adequate attention yet. Soil temperature patterns are generally well documented, and soil temperature is considered a key factor in limiting tree growth at both global and local scales. We performed a 2½-year monitoring in a near-natural treeline ...
Tópico(s): Ecology and Vegetation Dynamics Studies
2016 - Institute of Arctic and Alpine Research | Arctic Antarctic and Alpine Research
G. Glassmeier, Kathrin Hempel, Iris Wulfsen, Christiane K. Bauer, Udo Schumacher, Jürgen R. Schwarz,
HERG (human ether-à-go-go-related gene) K(+) currents fulfill important ionic functions in cardiac and other excitable cells. In addition, HERG channels influence cell growth and migration in various types of tumor cells. The mechanisms underlying these functions are still not resolved. Here, we investigated the role of HERG channels for cell growth in a cell line (SW2) derived from small cell lung cancer (SCLC), a malignant variant of lung cancer. The two HERG1 isoforms (HERG1a, HERG1b) as well as ...
Tópico(s): Neuroscience and Neural Engineering
2011 - Springer Science+Business Media | Pflügers Archiv - European Journal of Physiology
Martin Giersberg, Doreen M. Floß, Sergey M. Kipriyanov, Udo Conrad, Jürgen Scheller,
The tumor necrosis factor-alpha (TNFalpha) plays an important role in a number of chronic inflammatory disorders. Monoclonal camelidae variable heavy chain domain-only antibodies (V(H)H) have been developed to antagonize the action of human TNFalpha (anti-TNF-V(H)H). Here we describe a strategy to obtain functional dimeric anti-TNF-V(H)H molecules, based on the C-terminal fusion of a kappa light chain domain to the anti-TNF-V(H)H. The resulting fusion protein was transiently expressed by use of viral ...
Tópico(s): Toxin Mechanisms and Immunotoxins
2010 - Wiley | Biotechnology and Bioengineering
Doreen M. Floß, Kai Schallau, Stefan Rose‐John, Udo Conrad, Jürgen Scheller,
Elastin-like polypeptides (ELPs) are highly biocompatible and exhibit a potentially highly useful property: that of a thermally responsive reversible phase transition. These characteristics make ELPs attractive for drug delivery, appealing as materials for tissue repair or engineering, and improve the efficiency with which recombinant proteins can be purified. ELP fusion proteins (referred to as ELPylation) inherit the reversible phase transition property. ELPylation technology recently has been extended ...
Tópico(s): Silk-based biomaterials and applications
2009 - Elsevier BV | Trends in biotechnology
Marcus Panning, Markus Eickmann, Olfert Landt, Masyar Monazahian, Stephan Ölschläger, Sigrid Baumgarte, Udo Reischl, Jürgen J. Wenzel, Hans Helmut Niller, Stephan Günther, B. Hollmann, Daniela Huzly, Jan Felix Drexler, Angelika Helmer, Stephan Becker, B. Matz, Anna Maria Eis‐Hübinger, Christian Drosten,
Influenza A(H1N1)v virus was first identified in April 2009. A novel real-time RT-PCR for influenza A(H1N1)v virus was set up ad hoc and validated following industry-standard criteria. The lower limit of detection of the assay was 384 copies of viral RNA per ml of viral transport medium (95% confidence interval: 273-876 RNA copies/ml). Specificity was 100% as assessed on a panel of reference samples including seasonal human influenza A virus H1N1 and H3N2, highly pathogenic avian influenza A virus ...
Tópico(s): Virus-based gene therapy research
2009 - European Centre for Disease Prevention and Control | Eurosurveillance
Steffen Wolf, Marcus Böckmann, Udo Höweler, Jürgen Schlitter, Klaus Gerwert,
A computational approach to predict structures of rhodopsin‐like G protein‐coupled receptors (GPCRs) is presented and evaluated by comparison to the X‐ray structural models. By combining sequence alignment, the rhodopsin crystal structure, and point mutation data on the β 2 adrenoreceptor (b2ar), we predict a (−)‐epinephrine‐bound computational model of the β 2 adrenoreceptor. The model is evaluated by molecular dynamics simulations and by comparison with the recent X‐ray structures of b2ar. The overall ...
Tópico(s): Protein Structure and Dynamics
2008 - Wiley | FEBS Letters
Inga Peters, Bernhard Vaske, Knut Albrecht, Markus A. Kuczyk, Udo Jonas, Jürgen Serth,
Age, adiposity, and smoking are risk factors for the development of renal cell carcinoma. Hypermethylation of the RAS association domain family 1A gene (RASSF1A) promoter belongs to the most frequently detected epigenetic alterations in human cancers including renal cell carcinoma. RASSF1A is functionally involved in cell cycle control in normal cells and depletion promotes a number of cellular changes increasing the risk for neoplastic growth. We investigated the hypothesis that age, modulated by ...
Tópico(s): Birth, Development, and Health
2007 - American Association for Cancer Research | Cancer Epidemiology Biomarkers & Prevention
Inga Peters, Kristina Rehmet, Nadine Wilke, Markus A. Kuczyk, Jörg Hennenlotter, Tyark Eilers, S. Machtens, Udo Jonas, Jürgen Serth,
Epigenetic silencing of the RAS association domain family 1A (RASSF1A) tumor suppressor gene promoter has been demonstrated in renal cell carcinoma (RCC) as a result of promoter hypermethylation. Contradictory results have been reported for RASSF1A methylation in normal kidney, thus it is not clear whether a significant difference between RASSF1A methylation in normal and tumor cells of the kidney exists. Moreover, RASSF1A expression has not been characterized in tumors or normal tissue as yet.Using ...
Tópico(s): Cancer-related gene regulation
2007 - BioMed Central | Molecular Cancer
Andreas Krieger, Kayalvizhi Radhakrishnan, Alexey Pereverzev, Siarhei A. Siapich, Mohammed Banat, Marcel A. Kamp, Jérôme Leroy, Udo Klöckner, Jürgen Hescheler, Marco Weiergräber, Toni Schneider,
Multiple types of voltage-activated Ca2+ channels (T, L, N, P, Q, R type) coexist in excitable cells and participate in synaptic differentiation, secretion, transmitter release, and neuronal plasticity. Ca2+ ions entering cells trigger these events through their interaction with the ion channel itself or through Ca2+ binding to target proteins initiating signalling cascades at cytosolic loops of the ion conducting subunit (Cava1). These loops interact with target proteins in a Ca2+-dependent or independent ...
Tópico(s): Ion channel regulation and function
2006 - Karger Publishers | Cellular Physiology and Biochemistry
Meng Lin, Stefan Rose‐John, Joachim Grötzinger, Udo Conrad, Jürgen Scheller,
In murine models of Crohn's disease, rheumatoid arthritis and colon cancer, IL-6 (interleukin-6) signalling via the sIL-6R (soluble IL-6 receptor; termed IL-6 trans-signalling) has been shown to promote the pathology associated with these conditions. These detrimental activities can, however, be selectively blocked by soluble forms of the gp130 (glycoprotein 130) receptor. Although sgp130 (soluble gp130) therefore represents a viable therapeutic modality for the treatment of these conditions, the mass ...
Tópico(s): Toxin Mechanisms and Immunotoxins
2006 - Portland Press | Biochemical Journal
Udo Pagga, Jürgen Bachner, Uwe J. Strotmann,
Tópico(s): Environmental Science and Water Management
2006 - Elsevier BV | Chemosphere
For almost 15 years phage display is being used for the selection of specific antigen-binders from artificial libraries of single chain antibodies. Filamentous phages have been developed in a way to express foreign proteins on the surface and at the same time carrying the genetic information of the surface expressed molecule within the phage capsid. This property guarantees the coupling of phenotype and genotype during phage amplification and affinity selection. The possibility to generate large ...
Tópico(s): Advanced Biosensing Techniques and Applications
2005 - Bentham Science Publishers | Combinatorial Chemistry & High Throughput Screening
Christoph Schramm, Udo Herz, Jürgen Podlech, Martina Protschka, Susetta Finotto, Matthias J. Reddehase, Heinz Köhler, Peter R. Galle, Ansgar W. Lohse, Manfred Blessing,
Abstract Allergic asthma is characterized by airway hyperreactivity, inflammation, and a Th2-type cytokine profile favoring IgE production. Beneficial effects of TGF-β and conflicting results regarding the role of Th1 cytokines have been reported from murine asthma models. In this study, we examined the T cell as a target cell of TGF-β-mediated immune regulation in a mouse model of asthma. We demonstrate that impairment of TGF-β signaling in T cells of transgenic mice expressing a dominant-negative ...
Tópico(s): Neonatal Respiratory Health Research
2003 - American Association of Immunologists | The Journal of Immunology
M. Kuczyk, C. Bokemeyer, Julia Hartmann, Joke Schubach, CB Walter, S. Machtens, Robin Knuchel, C. Kollmannsberger, Udo Jonas, Jürgen Serth,
The p21WAF/Cip and the p27Kip1 genes have been identified as inductors of cell cycle arrest at the G1-checkpoint. Alterations of both genes have been suggested to be involved in the development of a variety of human malignancies due to a loss of critical antiproliferative mechanisms. To evaluate the prognostic importance of these alterations for patients with clinically localized prostate cancer, in 86 specimens (T1-T4) from 86 patients undergoing radical prostatectomy at the Department of Urology ...
Tópico(s): Cancer-related Molecular Pathways
2001 - Elsevier BV | Oncology Reports
Iris Bellinghausen, Udo Brand, Jürgen Knop, Joachim Saloga,
Background: Because of their production of IL-12, mature dendritic cells (DC) are potent inducers of TH1 responses. However, recent reports have demonstrated that DCs can also induce TH2 differentiation. Objective: In the current study we investigated which immune response is induced by DCs in naive CD45RA+ or memory CD45R0+ CD4+ T cells from atopic individuals (patients with grass pollen, birch pollen, or house dust mite allergy) compared with nonatopic control subjects. Methods: Immature DCs, generated ...
Tópico(s): Immune Cell Function and Interaction
2000 - Elsevier BV | Journal of Allergy and Clinical Immunology
Rezension von: Witlof Vollstadt/Klaus-Jurgen Tillmann/Udo Rauin/Katrin Hohmann/Andrea Tebrugge: Lehrplane im Schulalltag. Eine empirische Studie zur Akzeptanz und Wirkung von Lehrplanen in der Sekundarstufe I. ...
Tópico(s): Linguistic Education and Pedagogy
2000 - Verlagsgruppe Beltz | Zeitschrift für Pädagogik
Heike I. Grabsch, Alexei Pereverzev, Marco Weiergräber, Martin Schramm, Margit Henry, Rolf Vajna, Robert Beattie, Steve Volsen, Udo Klöckner, Jürgen Hescheler, Toni Schneider,
Polyclonal antibodies were raised against a common and a specific epitope present only in longer alpha1E isoforms of voltage-gated Ca(2+) channels, yielding an "anti-E-com" and an "anti-E-spec" serum, respectively. The specificity of both sera was established by immunocytochemistry and immunoblotting using stably transfected HEK-293 cells or membrane proteins derived from them. Cells from the insulinoma cell line INS-1, tissue sections from cerebellum, and representative regions of gastrointestinal ...
Tópico(s): Cellular transport and secretion
1999 - SAGE Publishing | Journal of Histochemistry & Cytochemistry
M.A. Kuczyk, S. Machtens, K Hradil, Joke Schubach, Whitney V. Christian, Ruth Knüchel, J.T. Hartmann, Carsten Bokemeyer, Udo Jonas, Jürgen Serth,
The p27Kip1 gene has been identified as inductor of cell cycle arrest at the G1 checkpoint to prevent entry of somatic cells into the S phase of the cell cycle when substantial DNA damage has occurred. It has been suggested that decreased expression of the p27Kip1 protein may contribute to the development of human malignancies due to loss of critical antiproliferative mechanisms. In the present study, 95 specimens (T1–T4) from 95 randomly selected patients undergoing radical prostatectomy at the ...
Tópico(s): Bladder and Urothelial Cancer Treatments
1999 - Springer Nature | British Journal of Cancer
Susannetom Dieck, Lydia Sanmartı́-Vila, Kristina Langnaese, Karin Richter, Stefan Kindler, Antje Soyke, Heike Wex, Karl‐Heinz Smalla, Udo Kämpf, Jürgen-Theodor Fränzer, Markus Stümm, Craig C. Garner, Eckart D. Gundelfinger,
The molecular architecture of the cytomatrix of presynaptic nerve terminals is poorly understood. Here we show that Bassoon, a novel protein of >400,000 Mr, is a new component of the presynaptic cytoskeleton. The murine bassoon gene maps to chromosome 9F. A comparison with the corresponding rat cDNA identified 10 exons within its protein-coding region. The Bassoon protein is predicted to contain two double-zinc fingers, several coiled-coil domains, and a stretch of polyglutamines (24 and 11 residues ...
Tópico(s): Microtubule and mitosis dynamics
1998 - Rockefeller University Press | The Journal of Cell Biology
B. Andes Hess, Udo Eckart, Jürgen Fabian,
A detailed theoretical study of the rearrangement of allene oxide to cyclopropanone and the racemization of substituted cyclopropanones and the isomerization of substituted cyclopropanones is presented. The rearrangement of allene oxide to cyclopropanone was found to proceed in a stepwise fashion in which allene oxide first undergoes conversion to oxyallyl via a newly found transition structure with subsequent ring closure of the oxyallyl to cyclopropanone. It is shown that a previously found transition ...
Tópico(s): Asymmetric Synthesis and Catalysis
1998 - American Chemical Society | Journal of the American Chemical Society
Udo Hees, Jürgen E. Schneider, Oliver Wagner, Manfred Regitz,
Antiaromatic Compounds; 28.1. A Synthesis of Pyrrole Derivatives from Tri-tert-butylazete and Isonitriles or Carbon Monoxide The kinetically stabilized azete 4 reacts with isonitriles 5 in a sequence of [4 + 1] cycloaddition and ring-opening steps to yield 2- and 3-imino substituted 2H- and 3H-pyrrole derivatives 8,9. The α-methylene isonitriles 10 react analogously, but the formation of 2- and 3-iminopyrroles is still followed by an [1,5]-shift which leads to 2- and 3-aminopyrroles 13,14. With carbon ...
Tópico(s): Organic Chemistry Cycloaddition Reactions
1990 - Thieme Medical Publishers (Germany) | Synthesis
Oliver Welzel, Daniel Boening, Armin Stroebel, Udo Reulbach, Jürgen Klingauf, Johannes Kornhuber, Teja W. Groemer,
On their way to the synapse and back, neuronal proteins are carried in cargo vesicles along axons and dendrites. Here, we demonstrate that the key parameters of axonal transport, i.e., particle velocities and pausing times can be read out from CCD-camera images automatically. In the present study, this is achieved via cross- and autocorrelation of kymograph columns. The applicability of the method was measured on simulated kymographs and data from axonal transport timeseries of mRFP-labeled synaptophysin. ...
Tópico(s): Neuroscience and Neuropharmacology Research
2009 - Springer Science+Business Media | European Biophysics Journal
Arthur C. Cope, Udo Axen, Elizabeth P. Burrows, Jürgen Weinlich,
... Skeleton, Ring Size, and Partial Structure1Arthur C. Cope, Udo Axen, Elizabeth P. Burrows, and Jürgen WeinlichCite this: J. Am. Chem. Soc. 1966, 88, ...
Tópico(s): Molecular Junctions and Nanostructures
1966 - American Chemical Society | Journal of the American Chemical Society
Peter Kämpfer, Elena Martín, N. Lodders, S. Langer, Peter Schümann, Udo Jäckel, Hans‐Jürgen Busse,
A Gram-stain-negative, rod-shaped, oxidase-positive, non-spore-forming bacterium (Sa15(T)) was isolated from the air in a duck barn. On the basis of 16S rRNA gene sequence similarity studies, the organism was grouped into the class gammaproteobacteria in the neighbourhood of the genus Fulvimonas. The quinone system consisted exclusively of ubiquinone Q-8. The polar lipid profile was mainly composed of the major lipids diphosphatidylglycerol, phosphatidylmonomethylethanolamine and phosphatidylcholine, ...
Tópico(s): Plant Pathogens and Fungal Diseases
2009 - Microbiology Society | INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY