Sadiq Umar, A.A. Abdelmalik, Sadiq Umar,
Vegetable oil with high percentage unsaturated fatty acid content are unstable to oxidation at elevated temperatures. However, epoxidation is an effective chemical reaction for chemical structural modification of such oil to eliminate unsaturated carbon–carbon double bond which is responsible for the instability of the oil. In this research, laboratory purified neem oil was epoxidized in situ in the presence of an acidic catalyst and the product was further transesterified. The purified (PNO), epoxidized ( ...
Tópico(s): Plant Surface Properties and Treatments
2018 - Elsevier BV | Industrial Crops and Products
Niyaz Ahmad, Md. Aftab Alam, Rizwan Ahmad, Sadiq Umar, Farhan Jalees Ahmad,
... article:Niyaz Ahmad, Md Aftab Alam, Rizwan Ahmad, Sadiq Umar & Farhan Jalees Ahmad (2018) Improvement of oral efficacy ...
Tópico(s): Drug Transport and Resistance Mechanisms
2018 - Taylor & Francis | Journal of Microencapsulation
Mir Sajad, Jamil Zargan, Raman Chawla, Sadiq Umar, Haider Ali Khan,
Tópico(s): Mitochondrial Function and Pathology
2010 - Springer Science+Business Media | Journal of Molecular Neuroscience
Faisal Hayat, Salahuddin Attar, Sadiq Umar, Amir Azam,
The cyclization of chalcones (1a–1j) with 2-(quinolin-8-yloxy) acetohydrazide (2) under basic condition led to the formation of new compounds, pyrazoline derivatives (3a–3j). In vitro antiamoebic activity was performed against HM1: IMSS strain of Entamoeba histolytica. The results showed that the compounds 3d, 3g, 3h, and 3j exhibited promising antiamoebic activity (IC50 = 0.05 μM, 0.31 μM, 0.06 μM, 0.29 μM) respectively than the standard drug metronidazole (IC50 = 1.84 μM). The toxicological studies of ...
Tópico(s): Cancer therapeutics and mechanisms
2010 - Elsevier BV | European Journal of Medicinal Chemistry
Jamil Zargan, Mir Sajad, Sadiq Umar, Mohammad Naime, Shakir Ali, Haider Ali Khan,
Tópico(s): Neuroscience and Neuropharmacology Research
2010 - Springer Science+Business Media | Molecular and Cellular Biochemistry
Jamil Zargan, Sadiq Umar, Mir Sajad, Mohammad Naime, Shakir Ali, Haider Ali Khan,
Venom of some species of scorpions induces apoptosis and arrests proliferation in cancer cells. This is an important property that can be harnessed and can lead to isolation of compounds of therapeutic importance in cancer research. Cytotoxicity was investigated using MTT reduction and confirmed with lactate dehydrogenase release following venom exposure. Apoptosis was evaluated with determination of mitochondrial membrane potential, reactive nitrogen species assay, measurement of Caspase-3 activity ...
Tópico(s): Nicotinic Acetylcholine Receptors Study
2011 - Elsevier BV | Toxicology in Vitro
Jamil Zargan, Mir Sajad, Sadiq Umar, Mohammad Naime, Shakir Ali, Haider Ali Khan,
The purpose of study was to examine the cytotoxic and anti-cancer properties along with addressing the plausible pathway followed by scorpion venom to reduce cell viability in SH-SY5Y and MCF-7 cells. Following exposure of cells with scorpion venom, cytotoxicity was estimated using MTT and lactate dehydrogenase assays. Apoptotic effects were measured by assessment of mitochondrial membrane potential, reactive nitrogen species, DNA fragmentation, and caspase-3 activity whereas antiproliferative effect ...
Tópico(s): Cell death mechanisms and regulation
2011 - Elsevier BV | Experimental and Molecular Pathology
Sadiq Umar, Anubhav Kumar, Mir Sajad, Jamil Zargan, Md. Meraj Ansari, Sayeed Ahmad, Chandra Kant Katiyar, Haider Ali Khan,
Tópico(s): Phytochemistry and Biological Activities
2012 - Springer Science+Business Media | Rheumatology International
Sadiq Umar, Mohammad Asif, Mir Sajad, Md. Meraj Ansari, Umar Hussain, Wasim Ahmad, Shadab A Siddiqui, Sayeed Ahmad, Haider Ali Khan,
The generation of reactive oxygen species (ROS) and other reactive nitrogen species (RNS) might be implicated to have a role in the pathogenesis of rheumatoid arthritis. Modulatory agents derived from plants that have properties like scavenging of free radicals clearly have therapeutic potential against these diseases. The present study was aimed to investigate the possible antioxidant potential of Trachyspermum ammi on collagen induced arthritis (CIA) in Wistar rat. Trachyspermum ammi extract (TAE) ...
Tópico(s): Phytochemistry and Biological Activities
2012 - | International Journal of Drug Development and Research
Sadiq Umar, Jamil Zargan, Khalid Umar, Sayeed Ahmad, Chandra Kant Katiyar, Haider Ali Khan,
Thymoquinone (TQ) is the major active compound derived from Nigella sativa. Our aim of this work was to evaluate the antioxidant and antiarthritic activity of TQ in Wistar rat by collagen induced arthritis (CIA). TQ was administered at a dose of 5 mg kg−1 body weight once daily for 21 days. The effects of treatment in the rats were assessed by biochemical (articular elastase, MPO, LPO, GSH, catalase, SOD and NO), inflammatory mediators (IL-1β, IL-6, TNF-α, IL-10, IFN-γ and PGE2) and histological studies ...
Tópico(s): Natural Compounds in Disease Treatment
2012 - Elsevier BV | Chemico-Biological Interactions
Sadiq Umar, Navin Kumar Mishra, Kaushal Pal, Mir Sajad, Neha, Md. Meraj Ansari, Sayeed Ahmad, Chandra Kant Katiyar, Haider Ali Khan,
Abstract Background/aim In the present study, the protective effect of rutin in ameliorating the disease process via markedly reducing the reactive oxygen species in joint destruction was demonstrated in collagen induced arthritis (CIA) model. Methods Arthritis was induced in male Wistar rats by CIA method. Rutin was administered at a dose of 25 mg kg −1 body weight once daily for 21 days. The effects of treatment in the rats were assessed by biochemical and histological evaluation in joints. Results ...
Tópico(s): Traditional Chinese Medicine Analysis
2012 - Medknow | Indian Journal of Rheumatology
Mir Sajad, Jamil Zargan, Raman Chawla, Sadiq Umar, Mir Sadaqat, Haider Ali Khan,
Tópico(s): Genomics, phytochemicals, and oxidative stress
2009 - Springer Science+Business Media | Molecular and Cellular Biochemistry
Sadiq Umar, Khalid Umar, Abu Hasnath Md. Golam Sarwar, Altaf Khan, Niyaz Ahmad, Sayeed Ahmad, Chandra Kant Katiyar, Syed Akhtar Husain, Haider Ali Khan,
Rheumatoid arthritis (RA) is a chronic inflammatory disease which leads to destruction of joints. Current treatment modalities for RA either produce symptomatic relief (NSAIDs) or modify the disease process (DMARDs). Though effective, their use is also limited by their side effects. As a result, the interest in alternative, well tolerated anti-inflammatory remedies has re-emerged. Our aim was to evaluate the antioxidant and antiarthritic activity of Boswellia serrata gum resin extract (BSE) in collagen ...
Tópico(s): Bone Metabolism and Diseases
2014 - Elsevier BV | Phytomedicine
Sai H. S. Boddu, Hashem O. Alsaab, Sadiq Umar, Sindhu Prabha Bonam, Himanshu Gupta, Salahuddin Ahmed,
Tópico(s): Neuropeptides and Animal Physiology
2014 - Elsevier BV | International Journal of Pharmaceutics
Saqlain Haider, Mohammad Sarwar Alam, Hinna Hamid, Syed Shafi, Abhijeet Dhulap, Firasat Hussain, Perwez Alam, Sadiq Umar, M. A. Qadar Pasha, Sameena Bano, Syed Nazreen, Yakub Ali, Chetna Kharbanda,
Tópico(s): Synthesis and Biological Evaluation
2014 - Elsevier BV | European Journal of Medicinal Chemistry
Niyaz Ahmad, Iqbal Ahmad, Sadiq Umar, Zeenat Iqbal, Mohd Samim, Farhan Jalees Ahmad,
Stroke is a one of the leading causes of disease and deaths worldwide, which causes irreversible deterioration of the central nervous system. Curcuminoids are reported to have a potential role in the amelioration of cerebral ischemia but they exhibit low serum and tissue levels due to low solubility and poor absorption. Curcumin (CUR), demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC)-loaded PNIPAM nanoparticles (NPs) were prepared by free radical polymerization and characterized for particles ...
Tópico(s): Nanoparticle-Based Drug Delivery
2014 - Taylor & Francis | Drug Delivery
Mir Sajad, Jamil Zargan, Mohammad Afzal Zargar, Jyoti Sharma, Sadiq Umar, Rajesh Arora, Haider Ali Khan,
Survival along with optimal proliferation of neuronal precursors determines the outcomes of the endogenous cellular repair in CNS. Cellular-oxidation based cell death has been described in several neurodegenerative disorders. Therefore, this study was aimed at the identification of the potent targets of oxidative damage to the neuronal precursors and its effective prevention by a natural flavonoid, Quercetin. Neuronal precursor cells (NPCs), Nestin+ and GFAP (Glial fibrillary acidic protein)+ were ...
Tópico(s): Alzheimer's disease research and treatments
2013 - Elsevier BV | NeuroToxicology
Sadiq Umar, Abu Hasnath Md. Golam Sarwar, Khalid Umar, Niyaz Ahmad, Mir Sajad, Sayeed Ahmad, Chandra Kant Katiyar, Haider Ali Khan,
Piperine, a main component of Piper species, is a plant alkaloid with a long history of medical use in a variety of inflammatory disorders like rheumatoid arthritis. Due to side effects in current treatment modalities of rheumatoid arthritis, the interest in alternative, well tolerated anti-inflammatory remedies has re-emerged. The aim of this work was to evaluate the anti-inflammatory and antiarthritic effects of piperine. Arthritis was induced in male Wistar rats by collagen induced arthritis ( ...
Tópico(s): Ginger and Zingiberaceae research
2013 - Elsevier BV | Cellular Immunology
Niyaz Ahmad, Sadiq Umar, Mohammad Ashafaq, Mohd Akhtar, Zeenat Iqbal, Mohd Samim, Farhan Jalees Ahmad,
Tópico(s): Medicinal Plants and Neuroprotection
2013 - Springer Science+Business Media | PROTOPLASMA
Sadiq Umar, Omar Hedaya, Anil Singh, Salahuddin Ahmed,
Tumor necrosis factor-α (TNF-α) is a pro-inflammatory cytokine produced by monocytes/macrophage that plays a pathological role in rheumatoid arthritis (RA). In this study, we investigate the effect of thymoquinone (TQ), a phytochemical found in Nigella sativa, in regulating TNF-α-induced RA synovial fibroblast (RA-FLS) activation. Treatment with TQ (1–5 μM) had no marked effect on the viability of human RA-FLS. Pre-treatment of TQ inhibited TNF-α-induced interleukin-6 (IL-6) and IL-8 production and ICAM- ...
Tópico(s): Natural Compounds in Disease Treatment
2015 - Elsevier BV | Toxicology and Applied Pharmacology
Anil Singh, Sadiq Umar, Sharayah Riegsecker, Mukesh Chourasia, Salahuddin Ahmed,
Transforming growth factor β-activated kinase 1 (TAK1) is a key MAPKKK family protein in interleukin-1β (IL-1β), tumor necrosis factor (TNF), and Toll-like receptor signaling. This study was undertaken to examine the posttranslational modification of TAK1 and its therapeutic regulation in rheumatoid arthritis (RA).The effect of TAK1, IL-1 receptor-associated kinase 1 (IRAK-1), and TNF receptor-associated factor 6 (TRAF6) inhibition was evaluated in IL-1β-stimulated human RA synovial fibroblasts (RASFs). ...
Tópico(s): Ubiquitin and proteasome pathways
2015 - Wiley | Arthritis & Rheumatology
Ankita Rathore, Raja Sudhakar, Mohamed Jawed Ahsan, Abuzer Ali, Naidu Subbarao, Surender Singh Jadav, Sadiq Umar, Mohammad Shahar Yar,
In search of potential therapeutics for inflammatory disease, we report herein the synthesis, characterization and anti-inflammatory activities of a new series of 1-{(5-substituted-1,3,4-oxadiazol-2-yl)methyl}-2-(morpholinomethyl)-1H-benzimidazoles (5a-r). The anti-inflammatory activity of the compounds was evaluated using carrageenan induced rat paw edema test. Some compounds showed excellent anti-inflammatory activity in carrageenan induced rat paw edema test. 1-{(5-(2-Chlorophenyl)-1,3,4-oxadiazol- ...
Tópico(s): Synthesis and Characterization of Heterocyclic Compounds
2016 - Elsevier BV | Bioorganic Chemistry
Mushtaq A. Tantray, Imran Khan, Hinna Hamid, Mohammad Sarwar Alam, Sadiq Umar, Yakub Ali, Kalicharan Sharma, Firasat Hussain,
A novel series of oxazolo[4,5-b]pyridine-2-one based 1,2,3-triazoles has been synthesized by click chemistry approach and evaluated for in vitro GSK-3β inhibitory activity. Compound 4g showed maximum inhibition with IC50 value of 0.19 μm. Keeping in view the effect of GSK-3β inhibition on inflammation, compounds 4g, 4d, 4f, 4i, 4n and 4q exhibiting significant GSK-3β inhibition were examined for in vivo anti-inflammatory activity in rat paw edema model. The compounds 4g, 4d, 4f and 4i showed pronounced ...
Tópico(s): Click Chemistry and Applications
2016 - Wiley | Chemical Biology & Drug Design
Tasiu Zangina, Jumiah Hassan, Raba′ah Syahidah Azis, Khamirul Amin Matori, Alex See, Ibrahim Mustapha Alibe, Sadiq Umar,
Lithium hafnium phosphate LiHf2(PO4)3 (LHP) was synthesized via solid-state synthesis technique. The sintering behavior, structure, and phase composition of the as-prepared sample was analyzed using X-ray diffraction (XRD) characterization technique. The XRD-Rietveld refinement analysis showed that after sintering at low temperatures 500 to 1000 °C, it exhibited various secondary phases. However, a single phase was observed as the sintering temperature increases from 1100 to 1200 °C. LHP sintered at ...
Tópico(s): Advancements in Battery Materials
2017 - Springer Science+Business Media | Journal of the Australian Ceramic Society
Katrien Van Raemdonck, Sadiq Umar, Zoltán Szekanecz, Ryan K. Zomorrodi, Shiva Shahrara,
Obesity can instigate and sustain a systemic low-grade inflammatory environment that can amplify autoimmune disorders and their associated comorbidities. Metabolic changes and inflammatory factors produced by the adipose tissue have been reported to aggravate autoimmunity and predispose the patient to cardiovascular disease (CVD) and metabolic comorbidities. Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) are autoimmune arthritic diseases, often linked with altered body mass index (BMI). Severe ...
Tópico(s): Diabetes and associated disorders
2018 - Elsevier BV | Autoimmunity Reviews
Katrien Van Raemdonck, Sadiq Umar, Karol Palasiewicz, Suncica Volkov, Michael V. Volin, Shiva Arami, Huan J. Chang, Brian Zanotti, Nadera Sweiss, Shiva Shahrara,
Tópico(s): Cytokine Signaling Pathways and Interactions
2019 - Springer Nature | Cellular and Molecular Life Sciences
Niyaz Ahmad, Farhan Jalees Ahmad, Sumit Bedi, Sonali Sharma, Sadiq Umar, Mohammad Azam Ansari,
To prepare a novel nanoemulsion- Carbopol® 934 gel for Eugenol, in order to prevent the periodontitis.Spontaneous emulsification method was used for the preparation of nanoemulsion in which it contain Eugenol (oil phase), Tween-80 (surfactant), and PEG (co-surfactant). To the development of best nanoemulsion, three-factor three-level central composite design was used in which %oil; %Smix and % water were optimized as independent variables. An optimized-nanoemulsion were converted to nanoemulsion-Carbopol® ...
Tópico(s): Drug Solubulity and Delivery Systems
2019 - Elsevier BV | Saudi Pharmaceutical Journal
Mohammad Ali Mosaberpanah, Sadiq Umar,
Yearly, approximately 750 million tons of rice husks is cultivated which generates about 160 million tons of rice husk that are eventually dumped on the environment as a waste to cover a large area of landfill and causes environmental pollution problems as well. The utilization of rice husk in concrete brings a great benefit in addressing both environmental and economic issues. During the combustion process, the lignin and cellulose content of rice husk is removed and a high amount of silica content ...
Tópico(s): Recycling and utilization of industrial and municipal waste in materials production
2019 - Elsevier BV | Materials Today Sustainability
Seung-Jae Kim, Huan J. Chang, Michael V. Volin, Sadiq Umar, Katrien Van Raemdonck, Aimee Chevalier, Karol Palasiewicz, John W. Christman, Suncica Volkov, Shiva Arami, Mehrdad Maz, Anjali Mehta, Ryan K. Zomorrodi, David A. Fox, Nadera Sweiss, Shiva Shahrara,
Synovial macrophages are crucial in the development of joint inflammation and bone damage; however, the pathways that control macrophage remodeling in inflammatory M1 cells or bone-eroding osteoclasts are not fully understood. We determined that elevated IL-7R/CD127 expression is the hallmark of rheumatoid arthritis (RA) M1 macrophages and that these cells are highly responsive to interleukin-7 (IL-7)-driven osteoclastogenesis. We established that lipopolysaccharide (LPS), interferon-γ (IFNγ), and tumor ...
Tópico(s): Bone Metabolism and Diseases
2019 - Springer Nature | Cellular and Molecular Immunology
Mahmood Ahmad Khan, Abu Hasnath Md. Golam Sarwar, Rani Rahat, Rafat Ahmed, Sadiq Umar,
Rheumatoid arthritis (RA) is an autoimmune disorder, in which imbalance in synthesis and production of inflammatory cytokines promotes cartilage and bone destruction. Out of the numerous factors contributing to RA prognosis, the transcription factor NF-kBp65 and p38 mitogen-activated protein kinase (p38MAPK) signaling module has been well implicated as a key regulator of inflammation and downstream signaling events in RA. Stigmasterol (STG) is a natural plant based product exhibiting anti-inflammatory ...
Tópico(s): T-cell and B-cell Immunology
2020 - Elsevier BV | International Immunopharmacology