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Artigo Brasil Produção Nacional Revisado por pares

David Valter Pereira, Amanda V. Steckert, Franciele Mina, Fabrícia Petronilho, Rafael Roesler, Gilberto Schwartsmann, Cristiane Ritter, Felipe Dal‐Pizzol,

Some studies have shown the role of gastrin-releasing peptide (GRP) on the production and release of cytokines both in animal models and in humans with inflammatory diseases, but there are no reports on the effects of GRP in ocular inflammatory disease, mainly uveitis. The authors report on the effects of the GRP receptor (GRPR) antagonist RC-3095 in a well-established model for uveitis induced by the administration of lipopolysaccharide (LPS), comparing its effects with those of glucocorticoids.Adult ...

Tópico(s): Mast cells and histamine

2009 - Cadmus Press | Investigative Ophthalmology & Visual Science

Artigo Brasil Produção Nacional Revisado por pares

David Valter Pereira, Fabrícia Petronilho, Hilda Regina Silveira Benevides Pereira, Francieli Vuolo, Francieli Mina, Jonathan Correa Possato, Marcelo F. Vitto, Daniela Roxo de Souza, Luciano da Silva, Marcos Marques da Silva Paula, Cláudio Teodoro de Souza, Felipe Dal‐Pizzol,

This study evaluates the effects of the gold nanoparticle in endotoxin-induced uveitis in rats.Adult male Wistar rats were divided into five groups: saline + saline, lipopolysaccharide (LPS) + saline, LPS + prednisolone, LPS + gold salt (GS) and LPS + gold nanoparticle (GNP). Two hours after LPS administration, prednisolone acetate 1%, GS, and GNP were topically applied to both eyes of rats and repeated every 6 hours for 24 hours. After 24 hours, rats were anesthetized and aqueous humor was sampled and the irides ...

Tópico(s): Corneal Surgery and Treatments

2012 - Cadmus Press | Investigative Ophthalmology & Visual Science

Artigo Acesso aberto Revisado por pares

Eduardo Luiz Pereira da Silva, Rafael Pereira, Luciano Neves Reis, Valter Luis Pereira, Luciana Aparecida Campos, Niels Wessel, Ovidiu Constantin Baltatu,

In the present study, we aimed at investigating a heart rate variability (HRV) biomarker that could be associated with the severity of the apnea–hypopnea index (AHI), which could be used for an early diagnosis of obstructive sleep apnea (OSA). This was a cross-sectional observational study on 47 patients (age 36 ± 9.2 standard deviation) diagnosed with mild (23.4%), moderate (34%), or severe (42.6%) OSA. HRV was studied by linear measures of fast Fourier transform, nonlinear Poincaré analysis, and detrended ...

Tópico(s): Asthma and respiratory diseases

2015 - Wolters Kluwer | Medicine

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Valter Abrantes Pereira da Silva, Martim Bottaro, Marco Aurélio Mendes Justino, Maurício Maltez Ribeiro, Ricardo Moreno Lima, Ricardo Jacó de Oliveira,

This study sought to compare maximum heart rate (HRmax) values measured during a graded exercise test (GXT) with those calculated from prediction equations in Brazilian elderly women.A treadmill maximal graded exercise test in accordance with the modified Bruce protocol was used to obtain reference values for maximum heart rate (HRmax) in 93 elderly women (mean age 67.1 +/- 5.16). Measured values were compared with those estimated from the "220-age" and Tanaka et al formulas using repeated-measures ANOVA. ...

Tópico(s): Blood Pressure and Hypertension Studies

2007 - Sociedade Brasileira de Cardiologia (SBC) | Arquivos Brasileiros de Cardiologia

Revisão Acesso aberto Brasil Produção Nacional Revisado por pares

Luciana Aparecida Campos, Valter Luis Pereira, Amita Muralikrishna, Sulayma Albarwani, Susana Brás, Sónia Gouveia,

Heart rate and blood pressure are the most important vital signs in diagnosing disease. Both heart rate and blood pressure are characterized by a high degree of short term variability from moment to moment, medium term over the normal day and night as well as in the very long term over months to years. The study of new mathematical algorithms to evaluate the variability of these cardiovascular parameters has a high potential in the development of new methods for early detection of cardiovascular ...

Tópico(s): Non-Invasive Vital Sign Monitoring

2013 - Frontiers Media | Frontiers in Physiology

Artigo Brasil Produção Nacional Revisado por pares

Andréia de Oliveira Pinheiro, Valter Luis Pereira, Ovidiu Constantin Baltatu, Luciana Aparecida Campos,

Aims:Elderly women with myocardial infarction (MI) show poorer outcomes than men. In patients with MI, reduced heart rate variability (HRV) is associated with an increased risk of mortality. Thus, we aimed to investigate HRV in elderly women with MI.Methods:HRV indexes in women 50 years of age or older were compared to those in age-adjusted men with MI: geometric (triangular index), linear (low frequency [LF, ms2], high frequency [HF, ms2], standard deviation (SD) of normal R-R wave intervals [SDNN], square ...

Tópico(s): Heart rate and cardiovascular health

2015 - Taylor & Francis | Current Medical Research and Opinion

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Osmar Pinto Neto, Andréia Oliveira Pinheiro, Valter Luis Pereira, Rafael Pereira, Ovidiu Constantin Baltatu, Luciana Aparecida Campos,

The aim of this study was to characterize the cardiac autonomic nervous system (ANS) through Morlet wavelet transforms of heart rate variability (HRV) and compare to Fast Fourier Transform (FFT) analysis. Cardiac sympathetic and parasympathetic blockades were studied in conscious rats. Morlet and FFT were performed in (1) high-frequency band (HF: 0.6 to 3 Hz), (2) mid-frequency band (MF: 0.3 to 0.6 Hz), and (3) low-frequency band (LF: 0.07 to 0.3 Hz). While cardiac sympathetic inhibition with metoprolol ...

Tópico(s): Cardiovascular and exercise physiology

2015 - Elsevier BV | Applied and Computational Harmonic Analysis

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Valter Luis Pereira, Mirela Dobre, Sandra Gomes dos Santos, Juliana Stefanin Fuzatti, Carlos Rocha Oliveira, Luciana Aparecida Campos, Andrei Brateanu, Ovidiu Constantin Baltatu,

Background: Atherosclerotic carotid intima-media thickness (IMT) may be associated with alterations in the sensitivity of carotid baroreceptors. The aim of this study was to investigate the association between carotid IMT and the autonomic modulation of heart rate variability (HRV). Methods: A total of 101 subjects were enrolled in this prospective observational study. The carotid IMT was determined by duplex ultrasonography. The cardiac autonomic function was determined through HRV measures during ...

Tópico(s): Blood Pressure and Hypertension Studies

2017 - Frontiers Media | Frontiers in Physiology

Artigo Brasil Produção Nacional Revisado por pares

Watilla Pereira Covre, Wendel Valter da Silveira Pereira, Deyvison Andrey Medrado Gonçalves, Orivan Maria Marques Teixeira, Cristine Bastos do Amarante, Antônio Rodrigues Fernandes,

Mineral exploration of copper (Cu) in the Amazon has significantly impacted the environment, leading to contamination of large areas that require remediation. Tropical tree species that can immobilize metals and restore plant cover should be selected for phytoremediation programs. The phytoremediation behavior of Khaya ivorensis and Cedrela fissilis was studied in Cu contaminated soil (60, 200, 400, and 600 mg kg−1). K. ivorensis absorbed extremely high amounts of Cu in the roots (329 mg kg−1) and ...

Tópico(s): Soil Management and Crop Yield

2020 - Elsevier BV | Journal of Environmental Management

Artigo Acesso aberto

Valter Pereira Romano, Rodrigo Duarte Seabra, Nathan Oliveira,

No cenário nacional, os estudos geolinguísticos têm alcançado inúmeros avanços desde 1963, ano em que Nelson Rossi publicou o primeiro atlas linguístico brasileiro, o Atlas Prévio dos Falares Baianos(ROSSI et al., 1963). O profícuo desenvolvimento da Geolinguística brasileira tem exigido investimentos em avanços tecnológicos no sentido de agilizar e otimizar o trabalho dos estudiosos na tarefa de elaboração dos atlas, seja em ferramentas audiovisuais para a coleta de dados, seja na criação de bancos ...

Tópico(s): Environmental and Ecological Studies

2014 - UNIVERSIDADE FEDERAL DE MINAS GERAIS | Revista de Estudos da Linguagem

Artigo Brasil Produção Nacional Revisado por pares

Watilla Pereira Covre, Sílvio Júnio Ramos, Wendel Valter da Silveira Pereira, Edna Santos de Souza, Gabriel Caixeta Martins, Orivan Maria Marques Teixeira, Cristine Bastos do Amarante, Yan Nunes Dias, Antônio Rodrigues Fernandes,

Improper disposal of copper mining wastes can threaten the ecosystem and human health due to the high levels of potentially toxic elements released into the environment. The objective of this study was to determine the properties of Cu mining wastes generated in the eastern Amazon and their potential risks to environment and human health. Samples of forest soil and artisanal/industrial Cu mining wastes were collected and subjected to characterization of properties and pseudo-total concentrations ...

Tópico(s): Heavy Metal Exposure and Toxicity

2021 - Elsevier BV | Journal of Hazardous Materials

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Valter Pereira Romano,

Esta obra fornece informacoes gerais sobre a Dialetologia, contextualizando as pesquisas geolinguisticas desenvolvidas no mundo, e mais especificamente, no Brasil. Constam do livro, tambem, questoes atinentes a metodologia do trabalho geolinguistico, contribuindo para a atualizacao daqueles que desenvolvem ou pretendem desenvolver atlas linguisticos. Ao final, a autora traz algumas reflexoes sobre as relacoes da Geolinguistica e o ensino de lingua materna.

Tópico(s): Spanish Linguistics and Language Studies

2011 - UNIVERSIDADE ESTADUAL DE LONDRINA | Signum Estudos da Linguagem

Artigo Brasil Produção Nacional Revisado por pares

Hamilton Ferreira de Souza Neto, Wendel Valter da Silveira Pereira, Yan Nunes Dias, Edna Santos de Souza, Renato Alves Teixeira, Maurício Willians de Lima, Sílvio Júnio Ramos, Cristine Bastos do Amarante, Antônio Rodrigues Fernandes,

Knowledge of arsenic (As) levels in gold (Au) mining areas in the Amazon is critical for determining environmental risks and the health of the local population, mainly because this region has the largest mineral potential in Brazil and one of the largest in the world. The objective of this study was to assess the environmental and human health risks of As in tailings from Au exploration in the eastern Amazon. Samples were collected from soils and tailings from different exploration forms from 25 points, ...

Tópico(s): Arsenic contamination and mitigation

2020 - Elsevier BV | Environmental Pollution

Artigo Brasil Produção Nacional Revisado por pares

Wendel Valter da Silveira Pereira, Renato Alves Teixeira, Edna Santos de Souza, Adriele Laena Ferreira de Moraes, Willison Eduardo Oliveira Campos, Cristine Bastos do Amarante, Gabriel Caixeta Martins, Antônio Rodrigues Fernandes,

Artisanal mining may have modified the mobility, bioavailability and bioaccessibility of potentially toxic elements (PTEs) in the Serra Pelada gold mine, eastern Amazon, Brazil, which has not yet been studied. The objectives were to perform chemical fractionation of barium (Ba), chromium (Cr), copper (Cu), nickel (Ni), lead (Pb), and zinc (Zn), and to determine the bioaccessibility of these elements in soils and mining wastes collected in agriculture, forest, mining, and urban areas from the influence ...

Tópico(s): Geochemistry and Geologic Mapping

2020 - Elsevier BV | Journal of Environmental Management

Artigo Brasil Produção Nacional Revisado por pares

Maurício Willians de Lima, Wendel Valter da Silveira Pereira, Edna Santos de Souza, Renato Alves Teixeira, Dulcidéia da Conceição Palheta, Kelson do Carmo Freitas Faial, Hain Figueiredo Costa, Antônio Rodrigues Fernandes,

Anthropogenic activities may have increased the concentrations of potentially toxic elements (PTEs) in fish from the southeastern Carajás Mineral Province in Brazil, which has not yet been studied. The objectives were to determine the quality parameters of surface water and bottom sediments, and to assess the bioaccumulation and risks of Al, Fe, Ba, Cd, Co, Cr, Cu, Mn, Mo, Ni, Pb, Ti, V and Zn in fish species from the southeastern Carajás Mineral Province. Water, sediments and fish species (Colossoma ...

Tópico(s): Heavy Metal Exposure and Toxicity

2021 - Elsevier BV | Environmental Research

Artigo Brasil Produção Nacional Revisado por pares

Renato Alves Teixeira, Wendel Valter da Silveira Pereira, Edna Santos de Souza, Sílvio Júnio Ramos, Yan Nunes Dias, Maurício Willians de Lima, Hamilton Ferreira de Souza Neto, Éder Silva de Oliveira, Antônio Rodrigues Fernandes,

Artisanal gold (Au) mining is the activity with the highest consumption of mercury (Hg) and the main source of environmental contamination by this element, which is a recurring problem in the Amazon . In this study, contamination and risks caused by Hg to the environment and human health were evaluated in different forms of artisanal Au mining in the Brazilian Amazon. For this purpose, 25 samples of soils and tailings were collected in three types of artisanal mine and one native forest. The mineralogical ...

Tópico(s): Heavy metals in environment

2021 - Elsevier BV | Chemosphere

Artigo Brasil Produção Nacional Revisado por pares

Wendel Valter da Silveira Pereira, Sílvio Júnio Ramos, Leônidas Carrijo Azevedo Melo, Anderson Martins de Souza Braz, Yan Nunes Dias, Gabriela Vilhena de Almeida, Antônio Rodrigues Fernandes,

Artisanal gold (Au) mining may have increased the concentrations of rare earth elements (REEs) in the Serra Pelada mine (southeastern Amazon, Brazil), which has not been evaluated so far. The objectives of this study were to determine the concentrations of cerium (Ce), lanthanum (La), scandium (Sc), and yttrium (Y) in the surroundings of the Serra Pelada mine, as well as the environmental risks associated with these elements. Therefore, 27 samples were collected in agricultural, forest, mining, and urban ...

Tópico(s): Heavy Metal Exposure and Toxicity

2022 - Elsevier BV | Environmental Research

Artigo Brasil Produção Nacional Revisado por pares

Yan Nunes Dias, Wendel Valter da Silveira Pereira, Marcela Vieira da Costa, Edna Santos de Souza, Sílvio Júnio Ramos, Cristine Bastos do Amarante, Willison Eduardo Oliveira Campos, Antônio Rodrigues Fernandes,

Artisanal gold mining has generated tailings highly contaminated by arsenic (As) in Cachoeira do Piriá, eastern Amazon, leading to severe risks to the environment. Such risks should be mitigated considering the bioavailable concentration of the element, since it implies immediate damage to the ecosystem. The objective of this study was to evaluate the potential of biochars in mitigating the environmental risks of bioavailable As concentrations in gold mining tailings from underground and cyanidation ...

Tópico(s): Coal and Its By-products

2022 - Elsevier BV | Journal of Environmental Management

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Anna Cássia de Holanda Sarmento, Cássia Regina Reis Muniz, Natália Rodrigues da Silva, Valter Alves Pereira, Maria Aparecida dos Santos Santana, Thiago Serravalle de Sá, Charbel Niño El-Hani,

Este artigo contempla uma investigação sobre princípios de design de uma sequência didática que visa favorecer a aprendizagem sobre metabolismo energético na primeira série do Ensino Médio. O estudo foi realizado por pesquisadores e professores-investigadores reunidos numa equipe colaborativa. Consideramos, na sequência, critérios de justificação a priori, relativos a aspectos epistemológicos, psicocognitivos e didáticos. Na validação a posteriori, utilizamos pré- e pós-testes, triangulando métodos ...

Tópico(s): Chemistry Education and Research

2013 - UNIVERSIDADE EST.PAULISTA JÚLIO DE MESQUITA FILHO | Ciência & Educação (Bauru)

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Deyvison Andrey Medrado Gonçalves, Wendel Valter da Silveira Pereira, Karen H. Johannesson, Daniel Vidal Peréz, Luiz Roberto Guimarães Guilherme, Antônio Rodrigues Fernandes,

The objectives of this study were to establish geochemical background values of aluminum (Al), iron (Fe), arsenic (As), barium (Ba), cadmium (Cd), cobalt (Co), chromium (Cr), copper (Cu), manganese (Mn), nickel (Ni), lead (Pb), vanadium (V), and zinc (Zn) for eastern Amazon soils and to assess the relationship between soil chemical and granulometric attributes using univariate and multivariate procedures. Samples from the topsoil (0–0.2 m) were collected in several areas with minimal or no human intervention. ...

Tópico(s): Radioactive element chemistry and processing

2022 - Multidisciplinary Digital Publishing Institute | Minerals

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Ádanna de Souza Andrade, Suezilde da Conceição Amaral Ribeiro, Bruno Wendell de Freitas Pereira, Valter Vinícius Pereira Brandão,

A fragmentação florestal é uma das principais consequências das atividades antrópicas em áreas de vegetação nativa. Quando considerada a abordagem de bacias hidrográficas, a fragmentação pode aumentar processos erosivos e alterar o regime hídrico, notadamente em decorrência das ações de desmatamento. Assim, no presente estudo buscou-se analisar a estrutura da paisagem da bacia hidrográfica do rio Marapanim-PA, com o enfoque na fragmentação da vegetação arbórea. Para isso, foi utilizada uma cena ...

Tópico(s): Agricultural and Food Sciences

2020 - UNIVERSIDADE FEDERAL DE SANTA MARIA | Ciência Florestal

Artigo Brasil Produção Nacional Revisado por pares

Wendel Valter da Silveira Pereira, Sílvio Júnio Ramos, Leônidas Carrijo Azevedo Melo, Yan Nunes Dias, Gabriel Caixeta Martins, Luana Cristina Gonçalves Ferreira, Antônio Rodrigues Fernandes,

Rudimentary methods are used to exploit gold (Au) in several artisanal mines in the Amazon, producing hazardous wastes that may pose risks of contamination by rare earth elements (REEs). The objectives of this study were to quantify the concentrations of REEs and assess their environmental and human health risks in artisanal Au mining areas in the northeastern Amazon. Thus, 25 samples of soils and mining wastes were collected in underground, colluvial, and cyanidation exploration sites, as well as ...

Tópico(s): Heavy Metal Exposure and Toxicity

2023 - Elsevier BV | Chemosphere

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Renato Pereira de Freitas, Valter S. Felix, Marcelo O. Pereira, Ramon Silva dos Santos, Ana Lúcia Crespo Oliveira, Elicardo Alves de Souza Gonçalves, Douglas Ferreira, André Rocha Pimenta, Leandro de Oliveira Pereira, M.J. Anjos,

In this work, microsamples extracted from a Saint John the Evangelist polychrome sculpture, dating from the beginning of the eighteenth century and found in Rio de Janeiro, Brazil, were analyzed with micro-XRF and complimentary X-ray Fluorescence (XRF) techniques, Raman Spectroscopy, and Optic Microscopy (OM). As a result of the study, the pigments azurite [2CuCO3·Cu(OH)2], massicot [PbO], vermilion [HgS], calcite [CaCO3] and gypsum [CaSO4.2H2O] were characterized. Through the images obtained by the microelemental ...

Tópico(s): Building materials and conservation

2019 - Elsevier BV | Microchemical Journal

Artigo Brasil Produção Nacional

Valter Pereira Romano,

Este artigo propoe-se a fazer um balanco critico da Geolinguistica no Brasil, uma vez que a elaboracao de atlas linguisticos tem alcancado inumeros avancos no territorio nacional desde seu inicio em 1963, ano em que Nelson Rossi publicou o primeiro atlas linguistico de um estado brasileiro, o Atlas Previo dos Falares Baianos (ROSSI, et al., 1963). Para tanto, parte de uma revisao da bibliografia com a finalidade de apresentar o estado da arte nesse cenario e propor uma divisao bipartida dos estudos ...

Tópico(s): Linguistics and Education Research

2013 - | Entretextos

Artigo Brasil Produção Nacional Revisado por pares

Marcelo O. Pereira, Valter S. Felix, Ana Lúcia Crespo Oliveira, Douglas Ferreira, André Rocha Pimenta, Cristiano Carvalho, Fabrício Lopes e Silva, Carlos A. Pérez, Douglas Galante, Renato Pereira de Freitas,

In this work, a painting suspected of counterfeiting was analyzed using the synchrotron-based scanning macro X-ray fluorescence (MA-XRF) technique. The canvas has erasures including a signature erasure; however, some visible numbers indicate that the artwork may be from the 17th century. Through the studies' elemental maps, Cl-K and Ca-K were observed, which allowed us to reconstruct the signature present in the painting. Elemental maps of Ba-K, Ti-K, Fe-K, Zn-K, and Pb-K were also obtained from ...

Tópico(s): X-ray Spectroscopy and Fluorescence Analysis

2020 - Elsevier BV | Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy

Artigo Acesso aberto Revisado por pares

Ângela Tamiko Sato Tahara, Rogéria Aparecida Pereira Valter de Lucena, Ana Paula Pessoa de Oliveira, Gilmara Ribeiro Santos,

Realizou-se uma revisão de literatura sobre Satisfação do Paciente em artigos publicados em periódicos internacionais e nacionais. Foram identificados os conceitos e as dimensões de satisfação, devido à importância da opinião do paciente e os pontos polêmicos/dificuldades para realização da pesquisa de satisfação do paciente, os quais consideramos como pontos em destaque. Realizada análise de vários estudos neste contexto para servir de base para uma pesquisa futura no sentido de medir a satisfação ...

Tópico(s): Medical Malpractice and Liability Issues

1997 - Associação Brasileira de Enfermagem | Revista Brasileira de Enfermagem

Artigo Brasil Produção Nacional Revisado por pares

Renato Pereira de Freitas, Filipe A. Coelho, Valter S. Felix, Marcelo O. Pereira, Marcos André Torres de Souza, M.J. Anjos,

This study used Raman, FT-IR and XRF spectroscopy and SEM to analyze ceramic fragments dating from the 19th century, excavated from an old farm in the municipality of Pirenópolis, Goiás, Brazil. The results show that the samples were produced in an open oven at a firing temperature below 500°C, using raw materials including kaolinite, hematite, magnetite, quartz, microcline, albite, anhydrite, calcite, illite, orthoclase and MnO2. Although the analyses showed similarities in the manufacturing process ...

Tópico(s): Conservation Techniques and Studies

2017 - Elsevier BV | Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy

Artigo Brasil Produção Nacional

Antônio Roberto Pereira, Valter Barbieri, Nílson Augusto Villa Nova,

For the sugarcane variety NA56–79 grown under field conditions in Araras-SP, Brazil, it is possible to forecast flowering based on the occurence of maximum and minimum daily temperatures during the inductive photoperiod. The frequency of nights with T min ⩾ 18°C and T max ⩽ 31°C discriminated those years with, from years without flowering. On average, flowering years had, during the inductive period, higher minimum and smaller maximum daily temperatures, higher rainfall and higher frequency of rainy ...

Tópico(s): Sugarcane Cultivation and Processing

1983 - Elsevier BV | Agricultural Meteorology

Artigo Brasil Produção Nacional Revisado por pares

Daniella J. P. C. Romanholi, Márcio Carlos Machado, Camila Canteiro Pereira, Débora Lucia Seguro Danilovic, Maria Adelaide Albergaria Pereira, Valter Ângelo Sperling Cescato, Malebranche B. C. Cunha Neto, Nina Rosa Castro Musolino, Berenice B. Mendonça, Luiz Roberto Salgado,

In the early postoperative period of Cushing's disease patients, desmopressin may stimulate ACTH secretion in the remnant corticotrophic tumour, but not in nontumour suppressed cells.The aim of this study is to evaluate the serum cortisol responses to desmopressin after pituitary surgery, establishing an optimal cut-off for absolute increment (Delta) of serum cortisol (F) suitable to predict recurrence risk.Retrospective case record study.Fifty-seven Cushing's disease patients submitted to pituitary ...

Tópico(s): Growth Hormone and Insulin-like Growth Factors

2008 - Wiley | Clinical Endocrinology