W.S. Boardman, P.V. Ellis, W.A. Everden, David Stone, David Preiskel,
... First among equals? South American man Safety valve Vasp The Brasimet Group Cable & Wireless Sifco Call On ...
1976 - Gale Group | The Economist
Carl May, Musleeha Chesor, Sarah Hunter, Bryony Hayes, Rachel Barr, Timothy P. L. Roberts, Fern A. Barrington, Louise K. Farmer, Lan Ni, Maisie Jackson, Heidi Snethen, Nadia Tavakolidakhrabadi, Max Goldstone, Rodney D. Gilbert, Matt Beesley, Rachel Lennon, Rebecca R. Foster, Richard J. Coward, Gavin I. Welsh, Moin A. Saleem,
... migratory phenotype with phosphorylation of the kinase JNK, VASP protein and docking protein Paxillin. This signaling was ... migratory phenotype with phosphorylation of the kinase JNK, VASP protein and docking protein Paxillin. This signaling was ... signal to podocytes resulting in vasodilator-stimulated phosphoprotein (VASP) phosphorylation and increased podocyte motility, with the signaling ... plasma lead to a podocin-dependent phosphorylation of VASP in podocytes via protease activated receptor-1.J ... plasma lead to a podocin-dependent phosphorylation of VASP in podocytes via protease activated receptor-1.J ...
Tópico(s): Complement system in diseases
2023 - Elsevier BV | Kidney International
David Morris, I.M. Daly, O. David, Richard Cottrell, Winston A. Cooper, Jim Lamberti, J.R. Thomson, Harold Hotelling, Jon S. Schwarzbach, Kaukab Siddique, G. Skelly, Robert Laidley, Ross Mcinnes, Michael Totten,
... Institute When Campos sowed and Delfim reaped Comind Vasp Tightrope to democracy Jornal Do Brasil DG Bank ...
1979 - Gale Group | The Economist
Monique M. Waldman, Jeremy Rahkola, Ashton L. Sigler, Jeffrey W. Chung, Benjamin A. S. Willett, Ross M. Kedl, Rachel S. Friedman, Jordan Jacobelli,
... interactions with APCs. Enabled/vasodilator-stimulated phosphoprotein (Ena/VASP) proteins are a family of cytoskeletal effector proteins ... at the leading edge of motile cells. Ena/VASP proteins have been implicated in motility and adhesion ... goal was to determine the contribution of Ena/VASP proteins to T cell–APC interactions, T cell ... results showed that naïve T cells from Ena/VASP-deficient mice have a significant reduction in antigen- ... cell expansion impairment were further confirmed in Ena/VASP-deficient T cells stimulated via dendritic cell immunization. ...
Tópico(s): Immunotherapy and Immune Responses
2022 - Frontiers Media | Frontiers in Immunology
By Peter Evans Home Affairs Correspondent, From Michael Hornsby, By Fred Emery Political Editor, By Patricia Tisdall and Donald Macintyre, From Patricia Clough, By Andrew Goodrick-Clarke Financial Editor, From Peter Hazelhurst, By David Felton Labour Reporter, By Ian Bradley, By George Clark Political Correspondent, By Christopher Warman and Nicholas Timmins, By Our Political Staff, By Diana Geddes Education Correspondent, By Stewart Tendler Crime Reporter, By Donald Macintyre Labour Reporter, From Clifford Webb, From Our Correspondent, By Our Planning Reporter, By Peter Hennessy, By Frances Gibb, By Hugh Clayton, By Dan van der Vat, By Kenneth Owen Technology Editor, From Lucy Hodges, By Pearce Wright Science Editor, From John Witherow, By Sara Bonner and John Winder, From Craig Seton, By Robin Young Consumer Affairs Correspondent, From Jan Murray, By David Wood, From John Earle, From Harry Debelius, From Richard Wigg, By Our Diplomatic Correspondent, From Charles Hargrove, From Our Own Correspondent, From Michael Binyon, From Tony Allaway, By David Spanier Diplomatic Correspondent, From David Cross, From Charles Harrison, From Eric Marsden, From Marie-Thérèse Delboulbes of Agence France-Presse, From David Bonavia, From Karan Thapar, From Stephen Taylor, by Arrigo Levi, From Ivor Davis, House of Commons, Shona Crawford Poole, Nicholas Timmins, Pat Healy Social Services Correspondent, Michael Ratcliffe, Stuart Evans, Philip Ziegler, Donald Earl, John Young, David Wood, Richard Owen, Tom Hutchinson, By John Grindley Meteorological Office, Nicholas Wapshott, Martin Huckerby, Mary Cosh, Anthony Masters, Ned Chaillet, Miles Kington, Stanley Sadie, Paul Griffiths, Hilary Finch, From John Woodcock Cricket Correspondent, By Sydney Friskin, By Norman Fox Football Correspondent, From John Hennessy, By Richard Streeton, By Srikumar Sen Boxing Correspondent, By John Blunsden, By Conrad Voss Bark, By Michael Phillips Racing Correspondent, By Pamela Macgregor-Morris, By Rex Bellamy Tennis Correspondent, David felton, Alan Hamilton, Bernard Levin, ADRIAN R. LONGLEY, , J. R. W. THIRLWELL, , ADAM FERGUSSON, , PETER TUKE, , MAXWELL ADAMS, , CHRISTOPHER MAYHEW, , HAROLD WILSON, , G. REULEAUX WUIDART, , RAY WILD, , TIM SAINSBURY, , C. A. PRENDERGAST, , A. D. D. McCALLUM, , ARTHUR GREIG, , AMBROSE APPELBE, , MICHAEL ANTHONY, , DAVID ROBERTS, , LEWIS MASSEY, , From Ronald Kershaw, By Cyril Bainbridge, By Our Music Reporter, By David Nicholson-Lord, By Geraldine Norman Sale Room Correspondent, T.C.R. writes:, Shirley Williams writes:, D. B. D. writes:, By Peter Hill and Philip Robinson, By John Hugley, By Roman Eisenstein Banking Correspondent, By John Whitmore, John Huxley, By Richard Allen, By Michael Prest, By Nicholas Hirst, By Derek Harris, Commercial Editor, By Philip Robinson, By Bill Johnstone, By John Huxley, Melvyn Westlake, By Peter Hill, By Edward Townsend, By Clifford Webb Midland Industrial Correspondent, HARRY STINSON, , C. G. NEWMAN, , CHARLES METCALFE, , C. P. MORTON, , R. O. LEAVOR, , J. S. THOM, , BY THE FINANCIAL EDITOR, Ross Davies, John Whitmore, Colin Perry, By Brian Appleyard, Michael Prest Mining Correspondent, By Catherine Gunn, By Rosemary Unsworth, By Peter Wainwright, Peter Davalle, Patrick Knight, Sue Branford, Nick Terdre, Jan Rocha, J.R., Peter Strafford,
... Linguarama, Bovis, The Sunday Times, Nationwide Building Society, Vasp, Banco Nacional, Gallaher, Halcyon Days Enamels, M. J. ...
1981 - Gale Group | TDA
Joana Zink, Maike Frye, Timo Frömel, Claudia Carlantoni, David John, Danny Schreier, Andreas Weigert, Hebatullah Laban, Gabriela Salinas, Heike Stingl, Lea Günther, Rüdiger Popp, Jiong Hu, Benoît Vanhollebeke, Hannes Schmidt, Amparo Acker‐Palmer, Thomas Renné, Ingrid Fleming, Peter M. Benz,
... angiogenesis, but underlying mechanisms are elusive. The Ena/VASP protein family, consisting of EVL, VASP, and Mena, plays a pivotal role in axon ... molecular level, we investigated the role of Ena/VASP proteins in angiogenesis. EVL and VASP, but not Mena, are expressed in endothelial cells ... mouse retina. Global deletion of EVL (but not VASP) compromises the radial sprouting of the vascular plexus ... signaling. SYNOPSIS This study reveals that the Ena/VASP protein family member EVL is a regulator of ... Genetic deletion of EVL (but not its homolog VASP) impairs the radial sprouting of the retinal vascular ...
Tópico(s): Axon Guidance and Neuronal Signaling
2021 - Springer Nature | EMBO Reports
Virtual asset service providers (VASPs) currently face a number of challenges, both from the technological and the regulatory perspectives. In the context of virtual asset transfers one key issue is the need for VASPs to securely exchange customer information to comply to the Travel Rule. We discuss a VASP information sharing network as one form of a trust infrastructure for VASP-to-VASP interactions. Related to this is the need for a trusted identity infrastructure for VASPs that would permit other entities to quickly ascertain ...
Tópico(s): Blockchain Technology Applications and Security
2020 - Springer Science+Business Media | Lecture notes in computer science
Norbert Donhauser, Eileen Socher, Sebastian Millen, Stefanie Heym, Heinrich Sticht, Andrea K. Thoma‐Kress,
... unknown. Here, we report that vasodilator-stimulated phosphoprotein (VASP), which promotes actin filament elongation, is a novel ... and HTLV-1 Gag cell-to-cell transfer. VASP contains an Ena/VASP homology 1 (EVH1) domain that targets the protein ... may mediate interactions with the EVH1 domain of VASP. Co-immunoprecipitations confirmed interactions of VASP:p8 in 293T, Jurkat and HTLV-1-infected MT-2 cells. Co-precipitation of VASP:p8 could be significantly blocked by peptides mimicking ... Mutational studies revealed that the EVH1-domain of VASP is necessary, but not sufficient for the interaction ...
Tópico(s): Vector-Borne Animal Diseases
2020 - Public Library of Science | PLoS Pathogens
Álvaro Torres-Gómez, Jose L. Sanchez‐Trincado, Víctor Toribio, Raúl Torres, Sandra Rodríguez, Marı́a Yáñez-Mó, Pedro A. Reche, Carlos Cabañas, Esther M. Lafuente,
... the implication of RIAM and its binding partner VASP in the signaling events occurring downstream of β2 ... 60 promyelocytic cell lines deficient in RIAM or VASP or overexpressing EGFP-tagged VASP to determine VASP dynamics at phagocytic cups. Our results indicate that ... integrin downstream signaling during complement-dependent phagocytosis. Similarly, VASP deficiency completely blocked phagocytosis, while VASP overexpression increased the random movement of phagocytic particles ... surface, with reduced internalization. Moreover, the recruitment of VASP to particle contact sites, amount of pSer157-VASP ...
Tópico(s): Complement system in diseases
2020 - Multidisciplinary Digital Publishing Institute | Cells
Pengchao Hu, Kai Li, Yihao Tian, Wenting Pan, Ying Wang, Xiaolong Xu, Yanqi He, Yang Gao, Lei Wei, Jingwei Zhang,
... Our previous series of studies have shown that VASP, as a key oncogene, plays an important role ... find that miR-638 can target to inhibit VASP expression, and Lin28 acts as an RNA-binding ... inhibits its maturation and promotes the expression of VASP.In addition, we also find that CREB1 acts ... Lin28 gene and activates the Lin28/miR-638/VASP pathway.Furthermore, CREB1 can also directly bind to the promoter of VASP, and activate VASP expression, forming a CREB/Lin28/miR-638/VASP interactive network, which plays an important role in ...
Tópico(s): MicroRNA in disease regulation
2019 - Ivyspring International Publisher | International Journal of Biological Sciences
Yihao Tian, Xu Liu, Yanqi He, Xiaolong Xu, Kai Li, Yanbin Ma, Yang Gao, De-Fei Wei, Lei Wei,
... botulinum toxin substrate (RAC1) and vasodilator‑stimulated phosphoprotein (VASP) in breast cancer cell migration. According to data ... Genome Atlas, increased expression levels of RAC1 and VASP in breast cancer are associated with decreased cancer ... stage and more aggressive tumor subtypes, while increased VASP mRNA expression levels are positively correlated with a ... to knock down the expression of RAC1 or VASP. Stable interference with the expression of RAC1 or VASP using RAC1‑shRNA or VASP‑shRNA, respectively, was ...
Tópico(s): Cancer Cells and Metastasis
2018 - Spandidos Publishing | Oncology Letters
Zhikui Liu, Yufeng Wang, Changwei Dou, Meng Xu, Liankang Sun, Liang Wang, Bowen Yao, Qing Li, Wei Yang, Kangsheng Tu, Qingguang Liu,
... as well as distal metastasis. Vasodilator-stimulated phosphoprotein (VASP), a regulator of actin cytoskeleton and cell migration, ... blot and IHC were used to detect the VASP expression in tissues and cells. Transwell and wound ... IP was used to show the interaction between VASP and CRKL. ChIP was used to analyze the binding of HIF-1α to VASP promoter region. Results: Our data involving both gain- and loss-of-function studies revealed that VASP activated AKT and ERK signaling and promoted HCC ... of MMPs. We investigated the positive correlation between VASP and an adapter protein, CRKL. VASP dynamically co- ...
Tópico(s): Cancer-related Molecular Pathways
2018 - Ivyspring International Publisher | Theranostics
Hebatullah Laban, Andreas Weigert, Joana Zink, Amro Elgheznawy, Christoph Schürmann, Lea Günther, Randa Abdel Malik, Sabrina Bothur, Susanne Wingert, Rolf Bremer, Michael A. Rieger, Bernhard Brüne, Ralf P. Brandes, Ingrid Fleming, P. Benz,
... We investigated the role of vasodilator-stimulated phosphoprotein (VASP) in vascular repair. After hindlimb ischemia induction, blood ... arteriogenesis, and leukocyte infiltration into ischemic muscles in VASP−/− mice were accelerated. VASP deficiency also elevated the polarization of the macrophages ... to promote leukocyte recruitment and vascular repair. Importantly, VASP deletion in bone marrow–derived cells was sufficient ... mimic the increased blood flow recovery of global VASP−/− mice. In chemotaxis experiments, VASP−/− neutrophils/monocytes were ...
Tópico(s): Receptor Mechanisms and Signaling
2018 - Rockefeller University Press | The Journal of Cell Biology
Stefan Brühmann, Dmitry S. Ushakov, Moritz Winterhoff, Richard B. Dickinson, Ute Curth, Jan Faix,
Ena/VASP proteins act as actin polymerases that drive the processive elongation of filament barbed ends in membrane protrusions ... on previous analyses of fast and slow elongating VASP proteins by in vitro total internal reflection fluorescence ... measurements, we established a kinetic model of Ena/VASP-mediated actin filament elongation. At steady state, it entails that tetrameric VASP uses one of its arms to processively track ... deliver monomers to the filament tip, suggesting that VASP operates as a single tetramer in solution or ...
Tópico(s): Cardiomyopathy and Myosin Studies
2017 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Lucila A. Acevedo, Alexander I. Greenwood, Linda K. Nicholson,
Vasodilator-stimulated phosphoprotein (VASP) is a processive actin polymerase with roles in the control of cell shape and cell migration. Through interaction with the cytoskeletal adaptor protein Zyxin, VASP can localize to damaged stress fibers where it serves to repair and reinforce these structures. VASP localization is mediated by its N-terminal Ena/VASP homology (EVH1) domain, which binds to the (W/ ... with four such motifs. This suggests that tetrameric VASP might bind very tightly to Zyxin through avidity, ...
Tópico(s): Cardiomyopathy and Myosin Studies
2017 - American Chemical Society | Biochemistry
Vasiliki Gkretsi, Andreas Stylianou, Triantafyllos Stylianopoulos,
... to respond to mechanical cues. Vasodilator-stimulated phosphoprotein (VASP) is an actin-polymerization regulator which interacts with ... protein Migfilin, and regulates cell migration. We compared VASP expression in MCF-7 and MDA-MB-231 ... that more invasive MDA-MB-231 cells overexpress VASP. We then utilized a 3-dimensional (3D) approach ... tumor spheroids, in the presence or absence of VASP. We show, for the first time, that VASP silencing downregulated Migfilin, β-catenin and urokinase plasminogen ... suggesting a matrix-independent mechanism. Tumor spheroids lacking VASP demonstrated impaired invasion, indicating VASP’s involvement in ...
Tópico(s): Cancer Cells and Metastasis
2017 - Elsevier BV | Experimental Cell Research
Patricia Zamorano, Natalie Marín, Francisco Córdova, Alejandra Aguilar, Cynthia J. Meininger, Mauricio P. Borić, Nikola Golenhofen, Jorge E. Contreras, José Sarmiento, Walter N. Durán, Fabiola A. Sánchez,
... PAF) induces S-nitrosylation of vasodilator-stimulated phosphoprotein (VASP) as a mechanism to reduce microvascular endothelial barrier ... and stimulate hyperpermeability. PAF elevated S-nitrosylation of VASP above baseline levels in different endothelial cells and ... membrane eNOS (GFPeNOSCAAX). PAF induced S-nitrosylation of VASP in cells with cytosolic eNOS but not in ... is anchored to the cell membrane. Reconstitution of VASP knockout myocardial endothelial cells with cysteine mutants of VASP demonstrated that S-nitrosylation of cysteine 64 is ...
Tópico(s): Protease and Inhibitor Mechanisms
2017 - American Physical Society | AJP Heart and Circulatory Physiology
Andrew W. Holt, Danielle N. Martin, Patti R. Shaver, Shaquria Adderley, Joshua D. Stone, Chintamani N Joshi, Jake T. Francisco, Robert M. Lust, Douglas A. Weidner, Brian M. Shewchuk, David A. Tulis,
... PKG target and actin-binding vasodilator-stimulated phosphoprotein (VASP). First, using the heme oxidant ODQ, cGMP content ... G:F actin, and increased PKG activity and VASP Ser239 phosphorylation (pVASP·S239) compared to VEH controls. ... used to generate overexpressing full-length wild type VASP (FL-VASP/WT), VASP Ser239 phosphorylation-mimetic (FL-VASP/239D) and VASP Ser239 phosphorylation-resistant (FL-VASP/239A) ASM cell mutants. Surprisingly, FL-VASP/239D negated the inhibitory effects of FL-VASP/ ...
Tópico(s): Renin-Angiotensin System Studies
2016 - Elsevier BV | Cellular Signalling
Punsiri M. Colonne, Caylin G. Winchell, Joseph G. Graham, Frances I. Onyilagha, Laura J. MacDonald, Heike Doeppler, Peter Störz, Richard C. Kurten, Paul A. Beare, Robert A. Heinzen, Daniel E. Voth,
... identified the actin regulatory protein vasodilator-stimulated phosphoprotein (VASP) as a PKA substrate that is increasingly phosphorylated ... virulent C. burnetii triggered increased levels of phosphorylated VASP in macrophage-like THP-1 cells and primary ... this event required the Cα subunit of PKA. VASP phosphorylation also required bacterial protein synthesis and secretion ... secretion system, indicating the pathogen actively triggers prolonged VASP phosphorylation. Optimal PV formation and intracellular bacterial replication ...
Tópico(s): Toxoplasma gondii Research Studies
2016 - Public Library of Science | PLoS Pathogens
Peter M. Benz, Hebatullah Laban, Joana Zink, Lea Günther, Ulrich Walter, Stepan Gambaryan, Karim Dib,
Vasodilator-Stimulated Phosphoprotein (VASP) is involved in the inhibition of agonist-induced platelet aggregation by cyclic nucleotides and the adhesion of platelets to ... key role in integrin signalling. We investigated whether VASP is involved in the regulation of Rap1b in platelets since VASP-null platelets exhibit augmented adhesion to endothelial cells in vivo.Washed platelets from wild type and VASP-deficient mice were stimulated with thrombin, the purinergic ... the GST-RalGDS-RBD binding assay. Interaction of VASP and Crkl was investigated by co-immunoprecipitation, confocal ...
Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema
2016 - BioMed Central | Cell Communication and Signaling
Daisy Riquelme, Aaron S. Meyer, Melanie Barzik, Amy E. Keating, Frank B. Gertler,
... members of the actin regulatory family of Ena/VASP proteins form stable tetramers. The vertebrate members of the Ena/VASP family, VASP, Mena and EVL, have many overlapping properties and ... may serve a regulatory role to refine Ena/VASP activity. While it has been assumed that family ... investigated systematically. Using cells expressing controlled combinations of VASP, Mena and EVL, we evaluated the composition of Ena/VASP oligomers and found that VASP forms oligomers without apparent bias with itself, Mena ...
Tópico(s): Cardiomyopathy and Myosin Studies
2015 - Portland Press | Bioscience Reports
Orit Siton, Anne Bernheim‐Groswasser,
Vasodilator-stimulated phosphoprotein (VASP) is active in many filopodium-based and cytoskeleton reorganization processes. It is not fully understood how VASP directly functions in actin-based motility and how ... bundles that grow from the surface of WT-VASP-coated beads induced movement of the beads. VASP promotes actin-based movement alone, in the absence ... nucleators. We propose that at physiological salt conditions VASP nucleation activity is too weak to promote motility and bundle formation. Rather, VASP recruits F-actin seeds from the solution and ...
Tópico(s): Muscle Physiology and Disorders
2014 - Elsevier BV | Journal of Biological Chemistry
Mehboob Ali, Lynette K. Rogers, Giovanni M. Pitari,
... with abnormal tumor cell survival. Vasodilator-stimulated phosphoprotein (VASP) is an actin binding protein regulating cell shape ... Ser239. This study examined the role of differential VASP Ser phosphorylation in regulating cell survival and apoptosis in human colon carcinoma cells.Selective inhibition of VASP Ser157 or Ser239 phosphorylation in colon cancer cells ... fragmentation.In human colon carcinoma cells suppression of VASP Ser157 phosphorylation reduced F-actin content and survival and increased apoptosis, while inhibition of VASP Ser239 phosphorylation increased F-actin content and survival ...
Tópico(s): Cellular Mechanics and Interactions
2014 - Elsevier BV | Life Sciences
Yan-ting Zhang, Lihui Xu, Qun Lu, Kunpeng Liu, Pei-Yan Liu, Fang Ji, Xiao-Ming Liu, Dong‐Yun Ouyang, Xian‐Hui He,
... that CuB treatment rapidly induced vasodilator-stimulated phosphoprotein (VASP) phosphorylation (i.e. activation) at the Ser157 residue and generated VASP clumps which were co-localized with amorphous actin ... cofilin-actin rods in melanoma cells. Knockdown of VASP or inhibition of VASP activation using PKA-specific inhibitor H89 suppressed CuB-induced VASP activation, actin aggregation and cofilin-actin rod formation. The VASP activation was mediated by cAMP-independent PKA activation ... inhibitor of adenylyl cyclase, had weak effect on VASP activation. Knockdown of either Gα13 or RhoA not ...
Tópico(s): Biochemical and Structural Characterization
2014 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Vanessa Aline Bernusso, João Agostinho Machado‐Neto, Fernando Vieira Pericole, Karla Priscila Vieira, Adriana Silva Santos Duarte, Fabı́ola Traina, Marc D.H. Hansen, Sara Teresinha Olalla Saad, Karin Spat Albino Barcellos,
Vasodilator-stimulated phosphoprotein (VASP) and Zyxin are interacting proteins involved in cellular adhesion and motility. PKA phosphorylates VASP at serine 157, regulating VASP cellular functions. VASP interacts with ABL and is a substrate of ... of tyrosine kinase activity. However, the function of VASP and Zyxin in BCR–ABL pathway and the role of VASP in CML cells remain unknown. In vitro experiments using K562 cells showed the involvement of VASP in BCR–ABL signaling. VASP and Zyxin inhibition decreased the expression of anti- ...
Tópico(s): Mast cells and histamine
2014 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Andrew Cheng, Norma Rizzo-DeLeon, Carole L. Wilson, Woo Je Lee, Sanshiro Tateya, Alexander W. Clowes, Michael W. Schwartz, Francis Kim,
... the role of the enzyme vasodilatory-stimulated phosphoprotein (VASP) as a downstream mediator of the anti-inflammatory ... fed a low-fat diet (LFD), levels of VASP Ser(239) phosphorylation, a marker of VASP activation, were dramatically reduced in aortic tissue of ... These effects of the HFD were recapitulated by VASP knockout, implying a physiological role for VASP to constrain inflammatory signaling and thereby maintain vascular insulin sensitivity. Conversely, overexpression of VASP in endothelial cells blocked inflammation and insulin resistance ...
Tópico(s): Antioxidant Activity and Oxidative Stress
2014 - American Physiological Society | AJP Endocrinology and Metabolism
Anne Vehlow, Daniel Soong, Gema Vizcay‐Barrena, Cristian Bodo, Ah-Lai Law, Upamali Perera, Matthias Krause,
... protrusion by regulating actin filament elongation via Ena/VASP proteins. However, it is unknown whether this mechanism ... RIAM-Lpd (MRL) protein family, harbour several Ena/VASP-binding sites (Krause et al, 2004; Lafuente et al, 2004). Ena/VASP proteins directly interact with actin to promote the ... filaments (Chesarone and Goode, 2009). Lpd recruits Ena/VASP proteins to the leading edge of cells thereby ... regulated by the Arp2/3 complex and Ena/VASP proteins (Krause et al, 2003; Pula and Krause, 2008). Mena but not other Ena/VASP proteins have been implicated in EGF-dependent breast ...
Tópico(s): Lipid Membrane Structure and Behavior
2013 - Springer Nature | The EMBO Journal
Mathieu Pankert, Jacques Quilici, Anderson Diendonné Loundou, Valentine Verdier, Marc Lambert, Pierre Deharo, Guillaume Bonnet, Bénédicte Gaborit, Pierre‐Emmanuel Morange, René Valéro, Anne Dutour, Jean-Louis Bonnet, Marie‐Christine Alessi, Thomas Cuisset,
... using platelet reactivity index vasodilator stimulated phosphoprotein (PRI VASP). Three hundred thirty-six patients (21.8%) were ... Incidence of high on-treatment platelet reactivity (PRI VASP >50%) was higher in obese than nonobese patients ( ... on-treatment platelet reactivity with prasugrel therapy (PRI VASP <20%) was lower in obese than nonobese patients: ... on-treatment platelet reactivity with prasugrel therapy (PRI VASP <20%) was lower in obese than nonobese patients: ... low on-treatment platelet reactivity (LTPR) as PRI VASP 102 cm for men and >88 cm for ...
Tópico(s): Venous Thromboembolism Diagnosis and Management
2013 - Elsevier BV | The American Journal of Cardiology
Jérémie Abtan, Johanne Silvain, Mathieu Kernéis, Stephen O’Connor, Olivier Barthélémy, J Vignalou, Farzin Beygui, Delphine Brugier, J.-P. Collet, Gilles Montalescot,
... developed to measure the vasodilator-associated stimulated phosphoprotein (VASP) platelet reactivity index (PRI) in clopidogrel-treated patients. ... treated patients. We assessed the accuracy of ELISA-VASP to identify high on-treatment platelet reactivity (HPR) ... 5 or 10 mg) using flow cytometry (FC-VASP) and the ELISA-VASP technique, light transmission aggregometry (LTA) and VerifyNow-P2Y12 assay (VN-P2Y12). When using the ELISA-VASP PRI, the rate of patients with HPR in ... patients. There was a strong correlation between ELISA-VASP PRI and FC-VASP PRI (r = 0.83, ...
Tópico(s): Venous Thromboembolism Diagnosis and Management
2013 - Thieme Medical Publishers (Germany) | Thrombosis and Haemostasis
Jingwei Zhang, Ke Su, Wentao Shi, Ying Wang, Pengchao Hu, Yang Wang, Lei Wei, Jin Xiang, Fang Yang,
Vasodilator-stimulated phosphoprotein (VASP) expression is upregulated in human cancers and correlates with more invasive advanced tumor stages. The aim of this study ... derived from Sophora species plants, acted on the VASP protein in human gastric cancer cells in vitro. VASP was expressed and purified. Intrinsic fluorescence spectroscopy was used to study the binding of matrine to VASP. CD spectroscopy was used to examine the changes in the VASP protein secondary structure. Human gastric carcinoma cell line ...
Tópico(s): Natural product bioactivities and synthesis
2013 - Springer Nature | Acta Pharmacologica Sinica