... File: Bookseller's Full Description in Letter to Vcd.; The Burndy Library Collection at the Huntington Library. ...
1868 - Gale Group | NCCO-STM 1of2
Elmer D. Lipp, Laurence A. Nafié,
Abstract Vibrational CD (VCD) spectra have been obtained in the amide I region of poly(γ‐benzyl‐ L ‐glutamate), using a Fourier transform ir VCD spectrometer operating at 4‐cm −1 resolution. These results reveal a new negative VCD band at 1650 cm −1 in addition to the previously observed negative positive VCD couplet centered at 1660 cm −1 . Fourier self‐deconvolution (FSD) of the VCD spectrum reveals three strong VCD component bands, rather than just two, as originally ... polarized E 1 mode at higher frequency. The VCD spectrum is reassigned on the basis of this ...
Tópico(s): Photoreceptor and optogenetics research
1985 - Wiley | Biopolymers
... Material Removed to Acc. File: Two Sheets of Vcd's Notes on Tension.; The Burndy Library Collection ...
1888 - Gale Group | NCCO SciTechMed 2 of 2
Valnoctamide (2-ethyl-3-methylpentanamide; VCD), an isomer of valpromide possessing both anxiolytic and antiepileptic properties, has been used as a tranquilizer in the treatment of anxiety and tension. As VCD is an isomer of valpromide (VPD), which is ... could be explained by pharmacokinetics. The pharmacokinetics of VCD have been studied in dogs following iv and oral administration (400 mg). Following iv administration, VCD was rapidly distributed and plasma levels declined in ... biphasic fashion. The mean terminal half-life of VCD was 1.9 ± 0.5 h and the ...
Tópico(s): Drug Transport and Resistance Mechanisms
1988 - Elsevier BV | Journal of Pharmaceutical Sciences
Waldemar Januszczak, Vladimir Putin, Hala Jaber, Ivan Pike, John Dugdale, Nicholas Pyke, Matthew Wall, Steven Simpson, Barbara Hall, Nigel Botherway, Colin Kitt, Nigel Ross, Fred Redwood, Jim Munro, Jon Swain, Helen Davies, Sally Brock, Nicholas Rufford, Rob Hughes, George Georgiou, John Peter, Pam Barrett, V S, Mark Hodgkinson, Tony Eldridge, Jonathan Cox, Jonathan Miller, Professor Gideon Garter, Amanda Ursell, Andrew Longmore, Gurdeep Grewal, J D, Susan d'Arcy, Tom Walters, Irene Hofman, Chris Shelley, Tim Nagle, Gareth Walsh, Frank Whitford, Ivo Tennant, J Phillips, Nicolette Jones, Ferdinand Mount, Sam Gilpin, Charles Peat, Kathryn Cooper, William Lewis, Ian Woosnam, David Smith, Virginia McKenna, Humphrey Carpenter, P D, David Cracknell Political Editor, Nick Pitt, Frederic Raphael, Neil Wormald, E P, Colin Bullen, Andrew Sullivan, Clive Davis, James Glover, Sally Brown, Andrew Porter, Tony Allen-Mills, Simon Wilde, Jonathan Ungoed-Thomas, Robert Winnett, Natasha Garnett, Tim Adams, Irwin Stelzer, Mike Pattenden, Peter Wilson, Rosie Millard, Naimat Arghandabi, Lawrence Dallaglio, David Dougill, Rachel Dobson, Nick Scott, Geraldine Hackett, Matthew Robinson, Nick Speed, Rob Maul, David Hewson, Harold Cohen, David Bond, Jonathon Carr-Brown, Margarette Driscoll, Alasdair Reid, Geraldine Hackett Education Correspondent, Hugh Canning, Jeremy Clarkson, David Cairns, Edward Porter, Peter Conradi, Andrew Oswald, Stewart Lee, Dean Nelson, Debbie Taylor, Victoria Segal, Patricia Nicol, Scott Morris, Sarah Dempster, K E Mawardy, Eben Black, Dave Pollard, John O'Donnell, John Simons, Graham Clutton, David Eimer, Lydia Slater, Karena Batstone, Clive Anderson, Robert Potts, Dr Martin Stephen, Shelley von Strunckel, Doug Sager, Paula Robinson, Phil Stockton, Rick Wakeman, Roger Eglin, Paul Donovan, Tom Conran, Dominique Coughlin, Pat Cash, Pat Hodgson, Tom Stubbs, Monsieur Mangetout, Chris Woodhead, Steve Boyd, Lucinda Kemeny, Jasper Gerard, Emma Thompson, Paul Driver, John Humphrys, Nicholas Hellen, Ian Hawkey, Alex Clark, Christopher Morgan, Lizzie Vann, Bert Wright, Paul Durman, Mark Ludlow, Lisa Grainger, Alicia Wyllie, Arnie Wilson, Mark Edwards, Robin Davis, Susan Clark, Stephen Amidon, Damian Barton, Harriet Perry, Hugo Barnacle, Bryan Oates, Christina Lamb, Tim Lawrence, Victoria O'Brien, Miranda Eeles, Raymond Keene, David Cracknell, Cosmo Landesman, Katrina Manson, Robbie Hudson, Diana Wright, Benji Wilson, Jay Leno, Dominic O'Connell, Stephen Jones, Barry Flatman, Uzi Mahnaimi, Richard Evans, Louise Armitstead, Michael Wright, D Douglas, Bennett Maxwell, Natalie Graham, Kate Rew, Caroline Donald, Nick Rennison, S D, Rob Ryan, Keith Wheatley, Jessica Brinton, Miranda Seymour, David Walsh, Helen Brown, Tom Maynard, Tiffanie Darke, Wilf Altman, Trevor Lewis, Colin McDowell, Stephen Armstrong, John Elliott, John King, Aleks Sierz, Bethan Cole, Roland White, Katrien Nachtergaele, Shane Watson, Alex Fortune, Richard Rae, Mark Franchetti, Ray Hutton, Lauren Quaintance, Marie Pierre Zielinsky, C Nixon, Linda Aston, Michael Sheridan, Clare Francis, Joan Woolard, Simon Potter, John Harlow, D J Taylor, Godfrey Smith, Helen Mound, Victoria Masterson, Don Black, John Waples, Richard de Melim, Jeremy Hart, A A Gill, Matthew Campbell, Robert MacFarlane, James Hillhouse, Trevor Clawson, Alice Elden, Amber Rust, John Carey, David Horspool, Tania Davenport, Nick Fielding, Stephen Pettitt, Anna Tobin, Claudia Croft, Will Iredale, Jonathan Calvert, John Spurling, T L, Maria McErlane, Sally Kinnes, Naomi Caine, Graeme Nation, David Wickers, Francis Warren, Nigel Powell, Roger Dobson, Minette Marrin, John Cornwell, Andrew Frankel, Graham Norwood, Jonathan Futrell, Rupert Steiner, Alan Yentob, William Lewis Business editor, Hugh Pearman, Andrew Davidson, Paul Stephen Lubicz, Dan Cairns, Justin Wintle, Dorothy Wade, David Smith Economics Editor, Cary Cooper, Sarah Baxter, Bob Dwyer, Stuart Kelly, Matthew Goodman, India Knight, Paul Gogarty, Chris Feetenby, Simon Howard, Ed Hughes, Jason Dawe, Dominic Rushe, Richard Lewis, Karen Robinson,
... Piano Quartest Chandos Chan 0698 Red=Luck Vanguard VCD 797927-2 Pop and Jazz Mary Lee's ...
2003 - Gale Group | Sunday Times HA GDA
... therapy, for the presence of vocal cord dysfunction (VCD) and to compare the diagnostic ability of flow ... participated, 12 (23.53%) had bronchoscopical evidence of VCD and were labeled as VCD-positive group and rest 39 were designated VCD negative. No statistically significant difference in pulmonary function test (prereversibility) results between the VCD-positive and VCD-negative patients was found. Reversible airway obstruction was observed in 75% of the patients of VCD-positive group and 67.65% of the patients ...
Tópico(s): Dysphagia Assessment and Management
2009 - Medknow | Lung India
Alexander Street
Stephen A. Tilles, Andrew F. Inglis,
To the Editor: Vocal cord dysfunction (VCD) is well known to asthma specialists as a masquerader of asthma that should be considered in patients who fail to respond to ... 120 (S94-138)Google Scholar Because asthma and VCD have overlapping symptoms (dyspnea, wheezing, chest tightness) and ... irritant exposures), using the clinical history to distinguish VCD from asthma may be difficult. However, VCD is more likely when a patient previously thought ... 1386Crossref PubMed Scopus (445) Google Scholar Exercise-induced VCD is a particularly common cause of dyspnea and ...
Tópico(s): Voice and Speech Disorders
2009 - Elsevier BV | Journal of Allergy and Clinical Immunology
Melissa J. Romero‐Aleshire, Maggie K. Diamond-Stanic, Alyssa H. Hasty, Patricia B. Hoyer, Heddwen L. Brooks,
... 1) mice were treated with 4-vinylcyclohexene diepoxide (VCD) and fed a high-fat (HF) diet for 16 wk. VCD destroys preantral follicles, causing early ovarian failure and ... menopause. After 12 wk on a HF diet, VCD-treated mice had developed an impaired glucose tolerance, ... AUC HF mice 13,455 +/- 643 vs. HF/VCD 17,378 +/- 1140 mg/dl/min, P < 0.05]. After 16 wk on a HF diet, VCD-treated mice had significantly higher fasting insulin levels (HF 5.4 +/- 1.3 vs. HF/VCD 10.1 +/- 1.4 ng/ml, P < 0. ... diet (HF 56.2 +/- 16.7 vs. HF/VCD 113.1 +/- 19.6 mg/dl x microU/ ...
Tópico(s): Ovarian function and disorders
2009 - American Physiological Society | AJP Regulatory Integrative and Comparative Physiology
Peter W. Holmes, Kenneth K. Lau, Marcus Crossett, Cathy LOW, Douglas N. Buchanan, Garun S. Hamilton, Philip G. Bardin,
Vocal cord dysfunction (VCD) often masquerades as asthma and reports have suggested that up to 30% of patients with asthma may have coexistent VCD. Diagnosis of VCD is difficult, in part because it involves laryngoscopy ... and expiration and may be useful in suspected VCD.Endoscopy and high resolution 320-slice dynamic volume ... subglottic stenosis and in a patient with confirmed VCD. Nine asthmatics with ongoing symptoms and suspected VCD also underwent 320-slice dynamic volume CT. Tracheal ... inspiration/expiration, were judged to be consistent with VCD.Studies of subglottic tracheal stenosis validated anatomical similarities ...
Tópico(s): Asthma and respiratory diseases
2009 - Wiley | Respirology
Rubén Niesvizky, James A. Reeves, Ian W. Flinn, Robert M. Rifkin, Billy Clowney, Nashat Gabrail, V. R. Phooshkooru, Veena Charu, Christopher H. Chay, Deyanira Corzo, Rachel Neuwirth, Robert Manges, Thomas A. Warr,
... myeloma (MM), Vc–thalidomide–dexamethasone (VcTD), Vc–dexamethasone (VcD), and Vc–melphalan–prednisone (VcMP), in previously untreated ... weeks (eight 21-day cycles) of induction with VcD (Vc 1.3 mg/m2, days 1, 4, ... arms should continue enrolling pts. Pts in the VcD, VcTD, and VcMP arms had median ages of ... and 32%, respectively, were non-Caucasian. In the VcD, VcTD, and VcMP arms, mean number of treatment ... 13 and 13.8 Vc doses, respectively. The VcD arm had the lowest rate of adverse events ( ... AEs (50% vs 39% and 36% in the VcD and VcMP arms, respectively), as well as peripheral ...
Tópico(s): HIV/AIDS drug development and treatment
2009 - Elsevier BV | Blood
Jonathan P. Parsons, Cathy Benninger, Miles Hawley, Gary Philips, L. Arick Forrest, John G. Mastronarde,
Vocal cord dysfunction (VCD) is the abnormal adduction of the vocal cords during inspiration causing extrathoracic airway obstruction. VCD has been described as a confounder of severe asthma. The influence of VCD among less severe asthmatics has not been previously ... total of 44 patients had both asthma and VCD. 15 patients had asthma without concomitant VCD. Females were predominant in both groups. Overall, the ... asthma (78%) and 72% of these patients had VCD. Few patients from either group had "classic" VCD ...
Tópico(s): Asthma and respiratory diseases
2009 - Elsevier BV | Respiratory Medicine
Yasushi Takai, John Canning, Gloria I. Perez, James K. Pru, Jennifer J. Schlezinger, David H. Sherr, Richard Kolesnick, Junying Yuan, Richard A. Flavell, Stanley J. Korsmeyer, Jonathan L. Tilly,
The industrial chemical, 4-vinylcyclohexene diepoxide (VCD), kills oocytes within immature follicles in the ovaries of mice and rats and is considered a potential occupational health hazard. It has been reported that VCD-induced follicle loss occurs via a cell death ... as the related executioner enzyme caspase-3 to VCD-induced ovotoxicity in mice using gene knockout technology. ... ip injections of either vehicle (sesame oil) or VCD (80 mg/kg body weight) for 15 d ( ... of primordial or primary follicle destruction resulting from VCD exposure were observed in wild-type vs. ASMase- ...
Tópico(s): Chemotherapy-induced organ toxicity mitigation
2002 - Oxford University Press | Endocrinology
Valery Andrushchenko, Zoya Leonenko, David T. Cramb, Hans van de Sande, Hal Wieser,
... at room temperature by means of vibrational CD (VCD) and infrared absorption (ir) spectroscopy, and atomic force ... and to phosphate groups was demonstrated. ψ‐Type VCD spectra resembling electronic CD (ECD) spectra, which appear ... characterized mainly by an anomalous, severalfold increase of VCD intensity. Such anomalous VCD spectra were assigned to DNA condensation with formation ... tight DNA particles responsible for the ψ‐type VCD spectra. Upon increasing the Cr 3+ ion concentration ... a B‐form before and after the condensation. VCD and ir as well as AFM proved to ...
Tópico(s): Mass Spectrometry Techniques and Applications
2002 - Wiley | Biopolymers
... bioactivated by hepatic CYP450 to the diepoxide metabolite, VCD, which destroys mouse small preantral follicles (F1). Since ovarian mEH may play a role in VCD detoxification, these studies investigated the expression and activity ... of VCH (7.4 mmol/kg/day) or VCD (0.57 mmol/kg/day); 4 h following ... increased in F1 (410 +/- 5% VCH; 292 +/- 5% VCD) and F2 (1379 +/- 4% VCH; 381 +/- 11% VCD) follicles following repeated dosing with VCH or VCD. Catalytic activity of mEH increased in F1 follicles following repeated dosing with VCH/VCD (381 +/- 11% VCH; 384 +/- 27% VCD). Visualized by ...
Tópico(s): Glutathione Transferases and Polymorphisms
2002 - Oxford University Press | Toxicological Sciences
Kary E. Thompson, I.G. Sipes, Ben Greenstein, Patricia B. Hoyer,
Repeated dosing with 4-vinylcyclohexene diepoxide (VCD) accelerates atresia via apoptosis in primordial and primary follicles in ovaries of rats. The mechanisms that control atresia and VCD-induced toxicity are unknown; however, they could involve ... with E2 could protect follicles normally destroyed by VCD-induced apoptosis. Female F344 rats were treated daily with E2, ER analogs, and/or VCD for 15 d. VCD alone caused a 50% reduction in primordial and ... Coinjection of E2 (0.1 mg/kg) and VCD (80 mg/kg) selectively protected primary follicles from ...
Tópico(s): Effects and risks of endocrine disrupting chemicals
2002 - Oxford University Press | Endocrinology
Xiaoming Hu, Jodi A. Flaws, I.G. Sipes, Patricia B. Hoyer,
... and primary) ovarian follicles by 4-vinylcyclohexene diepoxide (VCD) in rats is likely via acceleration of the ... study was designed to investigate possible effects of VCD dosing on the mitogen-activated protein kinases (MAPK)/ ... F344 rats were given a single dose of VCD (80 mg/kg i.p., 1 day—a ... extracts. Compared with control, a single dose of VCD caused a decrease in JNK activity and an ... small ovarian follicles. After repeated daily dosing with VCD for 10 or 15 days, JNK and p38 ... days, 1.48 ± 0.11 for 15 days, VCD/control, P < 0.01; JNK: 1.44 ± 0. ...
Tópico(s): Protein Kinase Regulation and GTPase Signaling
2002 - Oxford University Press | Biology of Reproduction
... methacholine challenge testing (MCT) provokes vocal cord dysfunction (VCD), as evidenced by inspiratory vocal cord closure on ... FVLs) demonstrate any changes that are suggestive of VCD. Design Prospective, controlled study. Setting Army medical center. ... baseline spirometry. Ten subjects had documented evidence of VCD, 12 subjects had exercise-induced asthma (EIA) and ... inspiratory vocal cord adduction was found in four VCD patients. Two patients had adducted vocal cords at ... the EIA or control groups had evidence of VCD at baseline or after undergoing MCT. Truncation of ...
Tópico(s): Voice and Speech Disorders
2002 - Elsevier BV | CHEST Journal
Patrick J. Devine, I.G. Sipes, Michael K. Skinner, Patricia B. Hoyer,
... rats with the occupational chemical 4-vinylcyclohexene diepoxide (VCD) causes selective depletion of the smallest preantral ovarian ... primary follicles was developed and its susceptibility to VCD was assessed. The in vivo sensitivity of neonatal rats to VCD dosing was first confirmed by daily injection of VCD (80 mg/kg/day ip) on postnatal days ( ... were sensitive to follicle depletion by incubation with VCD (≥30 μM), and follicle loss occurred in a ... manner (8–15 days). Evidence for apoptosis in VCD-exposed ovaries, as demonstrated in vivo, was obtained ...
Tópico(s): Sperm and Testicular Function
2002 - Elsevier BV | Toxicology and Applied Pharmacology
Jodi A. Flaws, Kevin L. Salyers, I.G. Sipes, Patricia B. Hoyer,
4-Vinylcyclohexene diepoxide (1-epoxyethyl-3,4-epoxycyclohexane, VCD), an industrial chemical, is a potential health hazard ... small preantral follicles in rats. We proposed that VCD destroys oocytes in these follicles because of their reduced capacity to detoxify VCD (convert VCD to tetrol, 4-(1,2-dihydroxy)ethyl-1, ... distinct follicular fractions. Tissues were incubated with [14C]VCD and media were assayed for [14C]tetrol by HPLC. In immature rats, conversion of VCD to tetrol in large preantral follicles and hepatocytes ...
Tópico(s): Effects and risks of endocrine disrupting chemicals
1994 - Elsevier BV | Toxicology and Applied Pharmacology
Laura E. Wright, Patricia J. Christian, Zelieann Rivera, William G. Van Alstine, Janet L. Funk, Mary Bouxsein, Patricia B. Hoyer,
... been developed using the chemical 4-vinylcyclohexene diepoxide (VCD). This study was designed to compare skeletal effects of VCD-induced ovarian failure to those associated with ovariectomy ( ... female mice were dosed daily with vehicle or VCD (160 mg/kg/d, IP) for 15 days ( ... for ovarian failure. At the mean age of VCD-induced ovarian failure (∼6 wk after onset of ... than controls 1 mo after OVX, whereas in VCD-treated mice, SpBMD was not lower than controls ... after ovarian failure (p < 0.05). Both VCD-induced ovarian failure and OVX led to pronounced ...
Tópico(s): Estrogen and related hormone effects
2008 - Oxford University Press | Journal of Bone and Mineral Research
Patrick A. Stone, John E. Campbell, Karinna H. Andrews, Mark C. Bates,
... potential mechanisms of device failure. Vascular closure devices (VCDs) are frequently used after diagnostic and interventional percutaneous procedures. Studies have shown that the use of VCDs, in contrast to manual compression, decreases the time ... Text PDF PubMed Scopus (152) Google Scholar Unfortunately, VCD adverse events can occur with significant short- and ... arterial-related events comparing standard compression therapy and VCDs. The StarClose Vascular Closure System (Abbott Vascular, Redwood City, Calif) is a clip-mediated VCD that is designed to provide extraluminal mechanical closure ...
Tópico(s): Venous Thromboembolism Diagnosis and Management
2008 - Elsevier BV | Journal of Vascular Surgery
Aileen F. Keating, Kathila S. Rajapaksa, I.G. Sipes, Patricia B. Hoyer,
... finite number of primordial follicles. 4-Vinylcyclohexene diepoxide (VCD) is a metabolite formed by epoxidation of 4- ... 2- and 7,8-4-vinylcyclohexene monoepoxide (VCM). VCD specifically destroys small preantral (primordial and small primary) ... is involved in ovarian metabolism of VCM to VCD. Further, microsomal epoxide hydrolase (mEH) can detoxify VCD to an inactive tetrol (4-(1,2-dihydroxy) ... 2-dihydroxycyclohexane). This study evaluated the effects of VCD-induced ovotoxicity on mEH in CYP2E1+/+ and −/− mice ( ... expression in the mouse ovary. Relative to control, VCD exposure caused follicle loss (p < 0.05) in ...
Tópico(s): Hormonal Regulation and Hypertension
2008 - Oxford University Press | Toxicological Sciences
Aileen F. Keating, I.G. Sipes, Patricia B. Hoyer,
4-vinylcyclohexene diepoxide (VCD) specifically destroys small pre-antral follicles in the rodent ovary. VCD can be detoxified to an inactive tetrol by ... GSH) by glutathione S-transferase (GST). Formation of VCD-GSH adducts in the mouse ovary 4 h after VCD exposure (0.57 mmol/kg/day) has been ... pi and mu during a time-course of VCD-induced ovotoxicity was evaluated in a neonatal mouse ... 4 (PND4) B6C3F(1) mice were incubated with VCD (15 microM) for 2, 4, 6, 8, 10, ... evaluated, or assessed for mRNA or protein expression. VCD did not cause follicle loss (p>0.05) ...
Tópico(s): Reproductive Biology and Fertility
2008 - Elsevier BV | Toxicology and Applied Pharmacology
Shannon Marie Fernandez, Aileen F. Keating, Patricia J. Christian, Nivedita Sen, James B. Hoying, Heddwen L. Brooks, Patricia B. Hoyer,
... rats with the occupational chemical 4-vinylcyclohexene diepoxide (VCD) depletes the ovary of primordial and primary follicles ... Postnatal Day 4 (PND 4) rat ovaries to VCD causes similar follicular depletion. This study was designed ... survival signaling pathways that may be associated with VCD-induced ovotoxicity in small preantral follicles. Female Fischer ... 28) were dosed daily (80 mg/kg/day VCD i.p.; 12 days in vivo), and PND 4 ovaries were cultured (VCD 20 or 30 microM; 8 days in vitro). ... genes whose expression was increased or decreased by VCD in both experiments (i.e., via both exposure ...
Tópico(s): Endometriosis Research and Treatment
2008 - Oxford University Press | Biology of Reproduction
A. F. Keating, Salvador M. Fernandez, Connie J. Mark-Kappeler, Namita Sen, I.G. Sipes, Patricia B. Hoyer,
4-Vinylcyclohexene diepoxide (VCD), an occupational chemical that specifically destroys primordial and small primary follicles in the ovaries of rats and mice, is ... Kit. This study compared the temporal effect of VCD on protein distribution of KIT and its downstream ... 344 rat ovaries were cultured in control media ± VCD (30 μM) for 2–8 days (d2–d8). ... primary (37% decrease) follicles within 2 days of VCD exposure. After d4, VCD reduced (P < 0.05) oocyte staining for KIT ( ... Total AKT and pFOXO3 were not affected by VCD at any time. Akt1 mRNA, as measured by ...
Tópico(s): Genomics, phytochemicals, and oxidative stress
2010 - Oxford University Press | Biology of Reproduction