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Artigo Acesso aberto Revisado por pares

Ashwin Abhang, Oly Katari, Rohan Ghadi, Dasharath Chaudhari, Sanyog Jain,

... distribution, and drug resistance. An epigenetic modulator, vorinostat (VOR) is known to enhance PTX efficacy and therefore ... of conventional PTX formulations, we designed PTX- and VOR-bound albumin nanoparticles (PTX-VOR-BSA-NPs) using antisolvent precipitation technique where albumin ... a carrier and a targeting agent. The PTX-VOR-BSA-NPs were of 140 nm size, polydispersity ... and 68% of entrapment efficiency for PTX and VOR, respectively. A bi-pattern release of both PTX and VOR was observed from PTX-VOR-BSA-NPs with ...

Tópico(s): Microtubule and mitosis dynamics

2023 - Springer Science+Business Media | Drug Delivery and Translational Research

Artigo Revisado por pares

Ingo K. Mellinghoff, Martin J. van den Bent, Deborah T. Blumenthal, Mehdi Touat, Katherine B. Peters, Jennifer Clarke, Joe Mendez, Liam Welsh, Warren Mason, Andreas F. Hottinger, Juan Manuel Sepúlveda-Sánchez, Wolfgang Wick, Riccardo Soffietti, Steven Schoenfeld, Dan Zhao, Shuchi S. Pandya, Lori Steelman, Islam Hassan, Patrick Y. Wen, Timothy F. Cloughesy,

... the World Health Organization (WHO) 2021 definition. Vorasidenib (VOR) – an oral, brain-penetrant, dual inhibitor of mutant ( ... patients (pts) were randomized 1:1 to receive VOR 40 mg daily or placebo (PBO) daily in ... pts were randomized across 10 countries: 168 to VOR and 163 to PBO. Of the 331 pts: ... BIRC was statistically significant in favor of the VOR arm (HR, 0.39; 95% CI, (0.27, 0.56); P=0.000000067). Median PFS: VOR: 27.7 mos; PBO: 11.1 mos. TTNI was statistically significant in favor of the VOR arm (HR, 0.26; 95% CI, (0.15, ...

Tópico(s): Ferroptosis and cancer prognosis

2023 - Lippincott Williams & Wilkins | Journal of Clinical Oncology

Editorial Revisado por pares

Martin Holtmann, Gerd Lehmkuhl, Paul L. Plener, Michael Kölch,

... und alle, die mit ihnen leben und arbeiten, vor enorme Herausforderungen gestellt. Nach einer anfänglichen Fokussierung auf ... den Herausforderungen der letzten Jahre gewachsen. Dies gilt vor allem für Schüler_innen, die während des Distanzunterrichts ... sich immer deutlicher abzeichnenden psychischen und somatischen Langzeitfolgen vor viele Herausforderungen. Aufbauend auf den bereits zu Beginn ... Collaborators, 2021). Es ist auffällig, dass dieser Anstieg vor allem bei Jugendlichen und jungen Erwachsenen besonders ausgeprägt ...

Tópico(s): Tryptophan and brain disorders

2023 - Hogrefe Verlag | Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie

Revisão Acesso aberto Revisado por pares

Mohamad Alfarghal, Mohammed Abdullah Algarni, Sujeet Kumar Sinha, Aishwarya Nagarajan,

... assesses the vestibule-ocular reflex by measuring the VOR gain and recording overt and covert saccades, these ... were included in this systematic review. The mean VOR gain for the patients with vestibular neuritis was ... 14 for the ipsilesional ear, whereas the mean VOR gain was > 0.80 in the contralesional ... vestibular neuritis. In patients with PICA lesions, the VOR gain for the ipsilesional ear was 0.90 ( ... 93). In patients with AICA lesions, the mean VOR gain was variable. Based on the above mean VOR gain findings, the authors propose the following adjective ...

Tópico(s): Cerebral Venous Sinus Thrombosis

2022 - Frontiers Media | Frontiers in Neurology

Artigo Acesso aberto Revisado por pares

Susan King, Kilian Dahlem, Faisal Karmali, Konstantina M. Stanković, D. Bradley Welling, Richard F. Lewis,

... does not correlate with the vestibulo-ocular reflex (VOR) amplitude-based metrics used to assess peripheral vestibular ... and dizziness in patients with VS relate to VOR metrics that are not based on response amplitude. ... and subjective (dizziness) vestibular dysfunction was quantified. The VOR was tested using two yaw-axis motion stimuli, ... head-on-body impulsive rotations. Imbalance correlated with VOR precision (the inverse of the trial-to-trial variability) and with low-frequency VOR dynamics (quantified with the time constant), and these ...

Tópico(s): Cerebral Venous Sinus Thrombosis

2022 - American Physiological Society | Journal of Neurophysiology

Artigo Acesso aberto Revisado por pares

Hung‐Tsung Hsiao, Jeffrey Chi-Fei Wang, Sheng‐Nan Wu,

Vortioxetine (VOR) is recognized to exert antidepressant actions. However, whether this drug modifies ionic currents in excitable cells remains ... study was to explore the electrophysiological effects of VOR and other related compounds in pituitary GH3 cells and in Neuro-2a cells. VOR suppressed the delayed-rectifier K+ current (IK(DR)) ... fluoxetine (10 μM), a compound structurally similar to VOR, mildly suppressed current amplitude. In continued presence of VOR, neither further addition of propranolol nor risperidone reversed ...

Tópico(s): Neuroscience and Neuropharmacology Research

2022 - Multidisciplinary Digital Publishing Institute | Biomedicines

Primary Document Acesso aberto

Hoffmann, Johann Wilibald,

Place of publication from NUC pre-1956. "Vorstellung unterschiedlicher Müntz-Edicten und Recessen von Anno 1676 bis auf gegenwärtiges 1680te Jahr": p. [ ...

0000 - Gale Group | The Making of Modern World

Artigo Acesso aberto Revisado por pares

Alexander Nast, Andreas Altenburg, Matthias Augustin, Wolf‐­Henning Boehncke, Peter Härle, Joachim Klaus, Joachim Koza, Ulrich Mrowietz, H.M. Ockenfels, Sandra Philipp, Kristian Reich, Thomas Rosenbach, Martin Schlaeger, Gerhard Schmid‐Ott, Michael Sebastian, Ralph von Kiedrowski, Tobias Weberschock, Corinna Dressler,

... Leitliniensprache und Symbolik Der Ausschluss einer TB wird vor Einleitung einer Therapie mit MTX oder einem Biologikum ... einer Netzwerk-Metaanalyse ausgewertet werden Wertvolle Informationen liefern vor allem Grafiken der Netzwerk-Geometrie (Abbildung 1): Jeder ... Kontraindikationen" und "Arzneimittelinteraktionen" siehe Langfassung der Leitlinie. Anwendungshinweise Vor der Behandlung: ▸ Meldung des Patienten an ein Psoriasisregister ... Kontraindikationen" und "Arzneimittelinteraktionen" siehe Langfassung der Leitlinie. Anwendungshinweise Vor der Behandlung: ▸ Meldung des Patienten an ein Psoriasisregister ...

Tópico(s): Complementary and Alternative Medicine Studies

2021 - Wiley | JDDG Journal der Deutschen Dermatologischen Gesellschaft

Jornais Acesso aberto

... Aus China, Balaeniceps Ner, Eine Wanderung in Australien, Vor Zehn Jahren in Californien Und Oregon, Das Kapitelhaus ...

1861 - Gale Group | NCCO SciTechMed 2 of 2

Artigo Revisado por pares

Marie‐Luise Schiffmann, Joachim Dissemond, Cornelia Erfurt‐Berge, Jürg Hafner, Babak Alexander Itzlinger‐Monshi, Hans Wilfried Jungkunz, Birgit Kahle, Alexander Kreuter, Karin Scharffetter‐­Kochanek, Stine Lutze, Klemens Rappersberger, Stefan W. Schneider, Anke Strölin, Cord Sunderkötter, Tobias Goerge,

... Es liegen kaum Angaben zur Inzidenz der LV vor. Fritsch et al. geben einen eigenen Erfahrungswert von ... Extremität liegt hier eine geringere Konzentration thrombolytischer Faktoren vor. Dies führt zu erhöhter Thromboseneigung [24]. Eine statistisch ... den Gefäßwänden, oft schwierig zu erkennen, sowie Fibrinthromben vor allem in Gefäßen der oberen und mittleren Dermis. ... ohne Nachweis prokoagulatorischer Parameter liegt eine primäre LV vor. Im Einzelfall kann eine Erweiterung der Diagnostik unter ... β2-Glykoprotein-1-Antikörper) Differenzialdiagnostisch kann die LV vor allem durch die typische Klinik (stechende Schmerzen, ganzjähriges ...

Tópico(s): Dermatological and COVID-19 studies

2021 - Wiley | JDDG Journal der Deutschen Dermatologischen Gesellschaft

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Jornais Acesso aberto

R. Dührkoop, W. Richter,

Essay: Wie Altmeister Dührkoop Vor Sein Hamburger Publikum Tritt, Literatur, Technische Neuerungen, Lehr-Und Versuchsanstalt Für Photographie, Lichtdruck Und Gravüre Zu München, Repertorium Atelierarbeiten, Bekanntmachungen ...

1906 - Gale Group | NCCO Photography

Artigo Acesso aberto Revisado por pares

Jill W. Maxwell, Shane D. Falcinelli, Alexey Nefedov, Corin L. Dorfmeier, Guoxin Wu, Morgan Dewey, Andrea L. Webber, Nancie M. Archin, David M. Margolis, Daria J. Hazuda, Richard J. O. Barnard, Bonnie J. Howell,

... agents (LRAs). The HDACi suberoylanilide hydroxamic acid (vorinostat [VOR]) has been employed in several clinical HIV latency ... we report on global gene expression responses to VOR and examine the longevity of the transcriptional response ... many genes are modulated at 6 h post-VOR treatment in HCT116, Jurkat, and primary resting CD4 ... return to baseline levels after an 18-h VOR-free period. With repeat exposure to VOR in resting CD4 T cells, we found similar ... showed consistent transcriptional changes after each exposure to VOR. We identified five host genes that were strongly ...

Tópico(s): Histone Deacetylase Inhibitors Research

2020 - American Society for Microbiology | Journal of Virology

Primary Document -- Manuscript Acesso aberto

Werner Vom Hofe, Peter Seifert,

... unserer Zeit 1871-1942: Taten unserer Ahnen 4000 vor - 1000 nach der Zeitrechnung. Propaganda Material. Hofe, Werner ...

1944 - Gale Group | ArchivesUnbound Holocaust Rare

Artigo Revisado por pares

Zhuangzhuang Li, Haiyan Wang, Hui Wang, Dongzhen Yu,

... characterize the specific relationship between vestibulo‐ocular reflex (VOR) gain and CS gain in patients with vestibular ... vHIT). The analysis of the horizontal semicircular canal VOR and CS gains was based on individual head ... group had significantly higher CS gain and lower VOR gain than the control group ( P <. 001). While there was no significant correlation between VOR and CS gains in the control group after adjusting for age and sex ( P =. 689), VOR gain negatively correlated with CS gain in the ... 0.853, P <. 001). The specific relationship between VOR and CS gains was characterized as y = −1. ...

Tópico(s): Cerebral Venous Sinus Thrombosis

2020 - Wiley | Otolaryngology