IEEE Xplore
Jyoti Kumar, Balapal S. Basavarajappa, Bannikuppe S. Vishwanath, T. Veerabasappa Gowda,
Three isoenzymes of phospholipase A2 (PLA2), VRV-PL-IIIc, VRV-PL-VII, and VRV-PL-IX were isolated from Daboia russelii snake venom. The venom, upon gel filtration on ... resolved into six peaks (DRG75 I-VI). The VRV-PL-IIIc was purified by subjecting DRG75II to ... Sephadex G-75 column. The other two isoenzymes VRV-PL-VII and VRV-PL-IX were purified by subjecting DRG75III to ... 25 column. Mol wt. for the three PLA2s, VRV-PL-IIIc, VRV-PL-VII, and VRV-PL-IX are 13.003kDa, 13.100kDa and 12.531kDa respectively. The VRV-PL-IIIc is not lethal to mice up ...
Tópico(s): Ion channel regulation and function
2014 - Elsevier BV | Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology
Farbod N. Rahaghi, Raúl San Jośe Estépar, Samuel Z. Goldhaber, Jasleen Minhas, Pietro Nardelli, Gonzalo Vegas‐Sánchez‐Ferrero, Isaac de La Bruere, Syed Moin Hassan, Stefanie Mason, Samuel Y. Ash, Carolyn E. Come, George R. Washko, Gregory Piazza,
... for this analysis. RV volume to LV volume (VRV/VLV) ratio was measured using a CT-based ... nor the proximal volumes were related to baseline VRV/VLV (VPROXIMAL_ART/VLUNG: R=0.32, P= ... Modified Miller Index was not related to baseline VRV/VLV (R=0.01, P=0.97). In response to therapy, there was a decrease in VRV/VLV (1.30±0.34 to 0.95± ... is used to compute the right ventricular volume (VRV) and left ventricular volume (VLV) and the corresponding ratio (VRV/VLV), pre (A) and post (B) treatment with ... volume density at baseline is associated with increased VRV/VLV ratio at baseline (G) without similar finding ...
Tópico(s): Radiation Dose and Imaging
2019 - Lippincott Williams & Wilkins | Circulation Cardiovascular Imaging
Lue Ping Zhao, Terry P. Lybrand, Peter B. Gilbert, Thomas R. Hawn, Joshua T. Schiffer, Leonidas Stamatatos, Thomas H. Payne, Lindsay N. Carpp, Daniel E. Geraghty, Keith R. Jerome,
... led to the identification of viral residue variants (VRVs), i.e., residues harboring a substitution compared to ... Next, generalized additive models were applied to model VRV temporal dynamics and to identify VRVs with significant and substantial dynamics (false discovery rate q-value < 0.01; maximum VRV proportion >10% on at least one day). Unsupervised learning was then applied to hierarchically organize VRVs by spatiotemporal patterns and identify VRV-haplotypes. Finally, homology modeling was performed to gain ...
Tópico(s): Animal Virus Infections Studies
2021 - Multidisciplinary Digital Publishing Institute | Viruses
Riyaz Mohamed, H.V. Shivaprasad, Noor Mohamed Jameel, Mysore A. Shekar, Bannikuppe S. Vishwanath,
... activities of purified basic multi-toxic PLA2 enzyme, VRV-PL-VIIIa from Vipera russelli snake venom along with in vitro activities is described. AP inhibited VRV-PL-VIIIa enzyme activity in a concentration dependent ... activities, it has been found that AP inhibited VRV-PL-VIIIa induced mouse paw edematogenic activity in ... dependant manner. Intramuscular co-injection of AP with VRV-PL-VIIIa (1:10 w:w) neutralized the VRV-PL-VIIIa induced myotoxocity. Sections of mouse thigh ... lactate dehydrogenase. Histopathological studies showed that administration of VRV-PL-VIIIa (i.p) along with AP mixture ...
Tópico(s): Insect and Pesticide Research
2011 - Bentham Science Publishers | Current Topics in Medicinal Chemistry
Shivalingaiah Sudharshan, Bhadrapura Lakkappa Dhananjaya,
... protein, Vipera russellii venom phospholipase A2 fraction VIIIa (VRV-PL-VIIIa), from Daboia russelii pulchella venom against ... and gram-negative bacteria.The antibacterial potential of VRV-PL-VIIIa in the presence and absence of ... minimum inhibitory concentration was determined by microdilution tests.VRV-PL-VIIIa demonstrated potent antibacterial activities against all ... 2 μg/mL. The anti-bacterial potential of VRV-PL-VIIIa was comparable to the standards gentamycin, ... or partial overlapping of the bactericidal/antimicrobial domains.VRV-PL-VIIIa demonstrated potent antibacterial activities against all ...
Tópico(s): Healthcare and Venom Research
2015 - BioMed Central | The Journal of venomous animals and toxins including tropical diseases
Bhaskarjyoti Prasad, Kempaiah Kemparaju, Kandarp Bhatt, T. Veerabasappa Gowda,
... multiple forms of phospholipase A2 (PLA2). Three PLA2s (VRV-PL-V, VRV-PL-VI and VRV-PL-VIIIa) have been purified and characterized in this laboratory. A PLA2(VRV-PL-IIIb) inhibiting platelet aggregation was purified from ... followed by gel filtration on Sephadex G-50. VRV-PL-IIIb is a basic (pI 7.3- ... LD50 of 5.2 mg/kg body weight. VRV-PL-IIIb inhibits ADP-induced platelet aggregation in ... anticoagulant, myotoxic and direct haemolytic activities. Antibodies to VRV-PL-IIIb showed a single precipitin line against ...
Tópico(s): Ion channel regulation and function
1996 - Elsevier BV | Toxicon
John Sharko, Georges Grinstein, Kenneth A. Marx,
... dataset. In this paper we describe Vectorized Radviz (VRV) which extends the number of dimensions through data flattening. We show how VRV increases the power of Radviz through these extra ... in the layout of the DAs. We apply VRV to the problem of analyzing the results of ... or cluster ensembles. We show how features of VRV help discern patterns across the multiple cluster sets. We use the Iris data set to explain VRV and a newt gene microarray data set used ... its utility. We then discuss further applications of VRV.
Tópico(s): Data Visualization and Analytics
2008 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Visualization and Computer Graphics
G.P. Jayanthi, S.R. Kasturi, T. Veerabasappa Gowda,
... Toxicon27, 875–885, 1989.—A neurotoxic phospholipase A2, VRV PL-V was purified from Vipera russelli venom ... step by CM-Sephadex C-25 column chromatography. VRV PL-V is a basic PLA2 with a ... of approximately 10,000. The lethal potency of VRV PL-V was greater than that of the crude V. russelli venom. VRV PL-V showed anticoagulant activity and induced edema in the foot pad of the mouse. VRV PL-V undergoes aggregation at pH 4.8. ...
Tópico(s): Healthcare and Venom Research
1989 - Elsevier BV | Toxicon
Veerabasappa T. Gowda, James J. Schmidt, John L. Middlebrook,
The most basic phospholipase A2 (PLA2), VRV-PL-VIIIa, was purified from (Sri Lankan) Vipera russelli venom. It is a major component of the venom, contributing over 40% to the whole venom PLA2 activity. The purity of VRV-PL-VIIIa was ascertained by electrophoresis and by reverse phase high-pressure liquid-chromatography (RP-HPLC). VRV-PL-VIIIa had an apparent mol. wt of ... was established up to the 39th residue. Pyridylethylated VRV-PL-VIIIa was digested with endoprotease Glu-C, ... agreement with the sequence data, polyclonal antiserum against VRV-PL-VIIIa cross-reacted in ELISA with ammodytoxin ...
Tópico(s): Ion channel regulation and function
1994 - Elsevier BV | Toxicon
Tolga N. Aynur, Yunho Hwang, Reinhard Radermacher,
... the efficiency of the multisplit variable refrigerant volume (VRV) system is investigated numerically. Similar to experimental results ... affect the indoor temperature control of the multisplit VRV system. However, it increases the energy consumption of the multisplit VRV system. A control strategy for the multisplit VRV system integrated with the heat recovery ventilation (HRV) ...
Tópico(s): Heat Transfer and Optimization
2008 - Taylor & Francis | HVAC&R Research
Tolga N. Aynur, Yunho Hwang, Reinhard Radermacher,
The variable refrigerant volume (VRV) air conditioning system needs to be operated in conjunction with a ventilation system, because the VRV system cannot provide any fresh air. The common ventilation unit used with the VRV system is the heat recovery ventilation (HRV) unit. ... of the HPD and HRV units to the VRV system was compared. It was found that the ... was found that the outdoor unit of the VRV system consumed 26.3% less energy for the ...
Tópico(s): Building Energy and Comfort Optimization
2008 - Elsevier BV | Energy and Buildings
Babu Uma, T. Veerabasappa Gowda,
The basic phospholipase A2 (VRV-PL-VIIIa) from Vipera russelli venom induces multiple toxic effects including neurotoxicity, myotoxicity, edema and hemorrhage. This phospholipase A2 has ... understand the mechanism of lung hemorrhage induction by VRV-PL-VIIIa was followed by chemical modification studies ... and anticoagulant activities were not neutralized. Carbamylation of VRV-PL-VIIIa resulted in the loss of lung ... and edema inducing activities. In contrast, carbamylation of VRV-PL-VIIIa in the presence of anisic acid ...
Tópico(s): Healthcare and Venom Research
2000 - Elsevier BV | Toxicon
Mika Tanei, Hirohide Yokokawa, Kenji Murai, Rino Sakamoto, Yu Amari, Soushin Boku, Akihiro Inui, Kazutoshi Fujibayashi, Yuki Uehara, Hiroshi Isonuma, Ken Kikuchi, Toshio Naito,
... virus nucleic acid test (Verigene Respiratory Virus Plus; VRV), the latter being the gold standard, were performed. ... into four groups: false negative (FN), RIADT− and VRV+; true positive (TP), RIADT+ and VRV+; true negative (TN), RIADT− and VRV−; and false positive, RIADT+ and VRV−. Groups were compared regarding age, sex, temperature, time ...
Tópico(s): Viral Infections and Outbreaks Research
2014 - BMJ | BMJ Open
V. Sivaramakrishnan, M. Ilamathi, Kalyan Sundar Ghosh, S. Sathish, T. Veerabasappa Gowda, Bannikuppe S. Vishwanath, Kanchugarakoppal S. Rangappa, Bhadrapura Lakkappa Dhananjaya,
... modeling, molecular dynamics and molecular docking studies on VRV-PL-V (Vipera russellii venom phospholipase A2 fraction- ... of His 47 and Asp 48 within the VRV-PL-V binding pocket as key residue for ... and identify the best potential specific inhibitor against VRV-PL-V. Additionally, the e-pharmacophore was generated for the best potential specific inhibitor against VRV-PL-V and reported here. The present study ... a guiding role in the experimental design of VRV-PL-V inhibitors that may provide better therapeutic ...
Tópico(s): Research on Leishmaniasis Studies
2015 - Wiley | Journal of Molecular Recognition
Manoj Kumar Bhat, S.R. Kasturi, T. Veerabasappa Gowda,
... anti PL-V Ig) to a neurotoxic PLA2 VRV PL-V neutralized the neurotoxic symptoms and lethality of VRV PL-V without affecting its in vitro phospholipase ... substrate. However, they inhibited the catalytic activity of VRV PL-V when synaptosomes were used as the ...
Tópico(s): Healthcare and Venom Research
1991 - Elsevier BV | Toxicon
Tolga N. Aynur, Yunho Hwang, Reinhard Radermacher,
... efficiency of the multi-split variable refrigerant volume (VRV) system is investigated in a field test under ... the indoor temperature control of the multi-split VRV system; instead it increases the indoor humidity ratio, ... effect on the efficiency of the multi-split VRV system.
Tópico(s): Adsorption and Cooling Systems
2008 - Taylor & Francis | HVAC&R Research
Yanping Zhou, Jingyi Wu, R.Z. Wang, Sumio Shiochi, Y.M. Li,
... order to evaluate the energy performance of the VRV air-conditioning system, a new simulation module is ... basis. The COP and PLR simulation of the VRV system are also examined, with average error of ... the test that the energy performance of the VRV system at part-load condition is better than ...
Tópico(s): Heat Transfer and Optimization
2007 - Elsevier BV | Energy and Buildings
T. Veerabasappa Gowda, John L. Middlebrook,
... from Naja nigricollis venom and two basic PLA2 (VRV-PL-V and VRV-PL-VIIIa) from Vipera russelli venom. The effects ... most potent at eliciting this effect, followed by VRV-PL-V and VRV-PL-VIIIa. The two most sensitive cell lines, ...
Tópico(s): Healthcare and Venom Research
1993 - Elsevier BV | Toxicon
Deyin Zhao, Xu Zhang, Ming Zhong,
... and reliable operation of air conditioning system. Although VRV research is booming in recent years, the general control strategy of VRV system is still to regulate refrigerant flow rate ... the novel control strategy would help to improve VRV system energy efficiency and reduce cooling energy consumption ...
Tópico(s): Infection Control and Ventilation
2015 - Elsevier BV | Energy and Buildings
H. F. Clark, Peter Refsing Andersen, Philip D. Lunger,
... to that of structural polypeptides of viper retrovirus (VRV) but two polypeptides, one of mol. wt. approx. ... 72000, were unique. Antigenic comparison of CSRV and VRV by agar gel immunodiffusion revealed that CSRV possesses ... antigenic determinant which is different to that of VRV. CSRV propagated in rattlesnake fibroma cells was demonstrated ...
Tópico(s): Venomous Animal Envenomation and Studies
1979 - Microbiology Society | Journal of General Virology
S.R. Kasturi, T. Veerabasappa Gowda,
... Toxicon27, 229–237, 1989.—A major phospholipase A2 (VRV PL-VIIIa) which constitutes 24% of the whole ... followed by gel filtration on Sephadex G-50. VRV PL-VIIIa is a basic protein with a ... russelli venom. The ld50 value (i.p.) of VRV PL-VIIIa is 5.3 mg/kg body ...
Tópico(s): Ion channel regulation and function
1989 - Elsevier BV | Toxicon
John W. Krebs, Jean S. Smith, Charles E. Rupprecht, James E. Childs,
... in foreign countries, variants of the rabies virus (VRVs) associated with dogs (7/12 involved known bite ... the cause of the rabies infections. In contrast, VRVs associated with bats (bat-associated VRVs or BAVs) were implicated as the cause of ...
Tópico(s): Poxvirus research and outbreaks
2000 - Wiley | Annals of the New York Academy of Sciences
Deyin Zhao, Ming Zhong, Xu Zhang, Xing Su,
... In this paper, ECI (Energy consumption intensity) of VRV (Variable refrigerant volume) system in office buildings located ... are recommended to do energy consumption predicting of VRV system in office buildings.
Tópico(s): Air Quality Monitoring and Forecasting
2016 - Elsevier BV | Energy
D. M. Lokeshwari, N. D. Rekha, Bharath Srinivasan, Vivek Hamse Kameshwar, K. Ajay Kumar,
... new compounds were evaluated for their in vitro VRV-PL-8a and H+/K+ ATPase inhibitor properties. ... some molecules amongst the designed series showed promising VRV-PL-8a and H+/K+ ATPase inhibitor properties. ...
Tópico(s): Chemical synthesis and pharmacological studies
2017 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
T. Veerabasappa Gowda, John L. Middlebrook,
VRV-PL-VIIIa, the most basic phospholipase A2 (PLA2) from the venom of Vipera russelli, induces multiple ... hemorrhage. Rabbit polyclonal anti-serum was raised against VRV-PL-VIIIa. The antiserum cross-reacted in enzyme- ... with two other PLA2 from the same venom, VRV-PL-V and VRV-PL-VI, and with ammodytoxin A, caudoxin and ... two hybridoma cell lines secreting monoclonal antibodies against VRV-PL-VIIIa were isolated. The monoclonal antibodies exhibited apparent binding affinities in ELISA with VRV-PL-VIIIa ranging over two orders of magnitude. ...
Tópico(s): Healthcare and Venom Research
1994 - Elsevier BV | Toxicon
Shigeki Kusa, Hiroshi Taniguchi, Hitoshi Hachiya, Shinsuke Miyazaki, Hiroaki Nakamura, Takashi Uchiyama, Yoshito Iesaka,
... initiating point of His amplitude, and VH and VRV indicate the initiating point of ventricular activation on ... had the same electrophysiological circuit. Also note that VRV preceded in VT1 but delayed in VT2 and ... relationship of ventricular activation sequence between VH and VRV (Figures 2 and 3) is also accounted for ...
Tópico(s): Cardiac pacing and defibrillation studies
2013 - Lippincott Williams & Wilkins | Circulation Arrhythmia and Electrophysiology
Bannikuppe S. Vishwanath, R. Manjunatha Kini, T. Veerabasappa Gowda,
... venom. Toxicon26, 713 – 720, 1988. — A phospholipase A2 (VRV PL-VI) from Vipera russelli venom was purified ... single step on CM-Sephadex C-25 column. VRV PL-VI is a basic protein with a ...
Tópico(s): Ion channel regulation and function
1988 - Elsevier BV | Toxicon
Stefano Bevilacqua, Sacha Matteucci, Matteo Ferrarini, Mirsad Kacila, Andrea Ripoli, Alessandra Baroni, Domenico Mercogliano, Mattia Glauber, Paolo Ferrazzi,
... perfusion flow (APF) and the venous reservoir volume (VRV) with and without vacuum application just after starting ... m 2 , p= 0.002), with a larger VRV (VAVD 1091.67± 421 ml versus GD 808. ...
Tópico(s): Diagnosis and Treatment of Venous Diseases
2002 - SAGE Publishing | Perfusion
Chad M. Cristina, John J. Sansalone,
... less than 10 vehicles/L of runoff volume (VRV), the runoff coefficient asymptotically approached a maximum value ... storms, with more than 10 vehicles/L (as VRV), the runoff coefficient asymptotically approached a lower maximum ...
Tópico(s): Hydrology and Watershed Management Studies
2003 - American Society of Civil Engineers | Journal of Environmental Engineering