Luigi Formicola, Alice Pannérec, Rosa Maria Correra, Barbara Gayraud-Morel, David Ollitrault, Vanessa Besson, Shahragim Tajbakhsh, Jennifer Lachey, Jasbir Seehra, Giovanna Marazzi, David Sassoon,
Degenerative myopathies typically display a decline in satellite cells coupled with a replacement of muscle fibers by fat and fibrosis. During this pathological remodeling, satellite cells are present at lower numbers and do not display a proper regenerative function. Whether a decline in satellite cells directly contributes to disease progression or is a secondary result is unknown. In order to dissect these processes, we used a genetic model to reduce the satellite cell population by ~70-80% which ...
Tópico(s): Mesenchymal stem cell research
2018 - Frontiers Media | Frontiers in Physiology