Jeremy Rundall, Brian Harrison, Richard Buckle, Will Ellsworth-Jones, John Fryer, Cameron Duodu, Jon Swain, Harold Hobson, Chris Ryder, Rob Hughes, Michael Manning, John Howkins, Berry Ritchie, James Poole, Ronald Blythe, Julian Symons, Colin Middleton Murry, lan Nairn, Richard Streeton, Philip Oakes, Bruce Page, Henry Brandon, Richard Milner, Mark Ottaway, Brian James, Keith Botsford, Cliff Temple, Derek Prouse, Derek Jewell, Patrick Campbell, Vivian Jenkins, Jean Sargeant, John Ballantine, Norman Harris, Geoff Whitten, Paul Eddy, D A Orton, Theo Saunders, Robin Marlar, Hugh Somerville, Robert Samuelson, Peter Tinniswood, Patrick Forman, Peter Lennon, Lorana Sullivan, John Stonehouse, Tony Geraghty, Brian Jackman, John Fryer Labour Correspondent, Tom Mitchell, John Hopkins, Celia Haddon, K, Derrik Mercer, Denis Herbstein, James Fox, Peter Wilsher, Port Elizabeth, Stanley Levenson, Eric Jacobs, James Wilson, Elaine Potter, Michael Pye, Eamonn McCann, Gwen Nuttall, Michael Bateman, John Bell, Stephen Aris, Jean Robertson, Brigid Keenan, R T Sweeney, Russell Miller, Tony Rocca, Dudley Doust, Felix Aprahamian, T. T. Davis, Philip Kleinman, Michael Hornsby Pattan, Susan Raven, Peter Clarke, James Margach Political Correspondent, Brain Jackman, Eric Ambler, Michael Moynihan, Brian Glanville, Graham Searjeant, Anthony Holden, Peter Dunn, Philip Johns, Martin Meredith, Andrew Blake, Marina Vaizey, Margery Fisher, Robert Whymant, Allan Hall, Lailan Young, Jason Temas, Christopher Matthew, Chris Mullins, M. F. Lloyd, Roland Adburgham, Muriel Bowen,
... Fourteenth Chronicle. Letters and Diaries of John dos Passos, edited by Townsend Ludington/Andre Deutsch £5.95 ...
1975 - Gale Group | Sunday Times HA GDA
Produção Nacional
Lílian Fernandes Arial Ayres, Raquel Elisabeth Cnossen, Camila Mendes dos Passos, Vanessa Doriguêtto Lima, Mara Rúbia Maciel Cardoso do Prado, Brenda Alves Beirigo,
RESUMO Objetivo Estimar a ocorrência do contato pele a pele imediato e sua associação aos fatores sociodemográficos, obstétricos, assistenciais e de nascimento em uma maternidade da Zona da Mata Mineira. Método Estudo transversal realizado com 222 primíparas por meio de entrevista e dados do prontuário. Os dados foram codificados, categorizados, digitados e analisados pelo programa Epi info 7.0. Utilizou-se a regressão logística múltipla. Resultados A ocorrência do contato pele a pele imediato foi ...
Tópico(s): COVID-19 Impact on Reproduction
2020 - UNIVERSIDADE FEDERAL DO RIO DE JANEIRO | Escola Anna Nery
Produção Nacional
Revisado por pares
Tatiane Melo Preisser, Vanessa Pecini da Cunha, Mariana Passos Santana, Vanessa Bastos Pereira, Denise Carmona Cara, Bianca Mendes Souza, Anderson Miyoshi,
Type 1 diabetes (T1D) is an autoimmune disease that culminates in beta cell destruction in the pancreas and, subsequently, deficiency in insulin production. Cytokines play a crucial role in the development of diabetes, orchestrating the recruitment and action of immune cells, to not only destroy insulin-producing cells but also preserve them. Therefore, the aim of this study was to investigate the effect of orally administered Lactococcus lactis MG1363 FnBPA+ strains carrying plasmids encoding IL- ...
Tópico(s): Diabetes Management and Research
2021 - Hindawi Publishing Corporation | Journal of Diabetes Research
Produção Nacional
Revisado por pares
Julia Sapienza Passos, Vanessa Franco Carvalho Dartora, Giovanna Cassone Salata, Isabella D. Malagó, Luciana B. Lopes,
Breast cancer is a major public health problem, affecting millions of people. It is a very heterogeneous disease, with localized and invasive forms, and treatment generally consists of a combination of surgery and radiotherapy followed by administration of estrogen receptor modulators or aromatase inhibitors. Given its heterogeneity, management strategies that take into consideration the type of disease and biological markers and can provide more personalized and local treatment are required. More ...
Tópico(s): Nanoparticle-Based Drug Delivery
2023 - Elsevier BV | International Journal of Pharmaceutics
Produção Nacional
Revisado por pares
Régis Goulart Rosa, Alexandre Biasi Cavalcanti, Luciano César Pontes Azevedo, Viviane Cordeiro Veiga, Denise de Souza, Rosa da Rosa Minho dos Santos, Raíne Fogliati de Carli Schardosim, Gabriela Soares Rech, Geraldine Trott, Daniel Schneider, Caroline Cabral Robinson, Tainá Aparecida Haubert, Victoria Emanuele Lobo Pallaoro, Liége Gregoletto Brognoli, Ana Paula de Souza, Lauren Sezerá Costa, Bruna Machado Barroso, Melissa Pezzetti Pelliccioli, Janine Gonzaga, Nicole dos Santos Studier, Ana Paula Aquistapase Dagnino, Juliana de Mesquita Neto, Sabrina Souza da Silva, Bruna dos Passos Gimenes, Vanessa Brzoskowski dos Santos, Gabriel Pozza Estivalete, Carolina de Moraes Pellegrino, Carísi Anne Polanczyk, Letícia Kawano-Dourado, Bruno Martins Tomazini, Thiago Lisboa, Cassiano Teixeira, Fernando G. Zampieri, Alexandre Prehn Zavascki, Bernard J. Gersh, Álvaro Avezum, Flávia Ribeiro Machado, Otávio Berwanger, Renato D. Lópes, Maicon Falavigna,
To assess the association between acute disease severity and 1-year quality of life in patients discharged after hospitalisation due to coronavirus disease 2019 (COVID-19). We conducted a prospective cohort study nested in 5 randomised clinical trials between March 2020 and March 2022 at 84 sites in Brazil. Adult post-hospitalisation COVID-19 patients were followed for 1 year. The primary outcome was the utility score of EuroQol five-dimension three-level (EQ-5D-3L). Secondary outcomes included all- ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2023 - Springer Science+Business Media | Intensive Care Medicine
Produção Nacional
Revisado por pares
Marielton dos Passos Cunha, Vanessa Neiva Guimarães, Menira Souza, Divina das Dôres de Paula Cardoso, Tâmera Nunes Vieira Almeida, Thaís Santana de Oliveira, Fabíola Souza Fiaccadori,
Dengue virus type 1 (DENV-1) was the first serotype introduced in Brazil, during in the 1980s. Since then, this virus has spread in the Brazilian territory, causing several outbreaks. In 2013 the highest number of dengue cases was notified, when compared to the previous years in Brazil, and the state of Goiás reported over 160 thousand cases. In this study, we aimed to present the Phylodynamics of DENV-1 isolates from the state of Goiás, Brazil, during 2013 outbreak, based on the envelope gene (E) ...
Tópico(s): Plant and animal studies
2016 - Elsevier BV | Infection Genetics and Evolution
Produção Nacional
Revisado por pares
Vanessa Passos Brustein, F. V. Souza-Araújo, Antônio Fernando de Melo Vaz, Ricardo Vieira Araujo, Patrícia Maria Guedes Paiva, Luana Cassandra Breitenbach Barroso Coelho, Ana Maria dos Anjos Carneiro-Leão, J. A. Teixeira, Maria G. Carneiro‐da‐Cunha, Maria Tereza dos Santos Correia,
The present work reports the purification and partial characterization of an antibacterial lectin (EmaL) obtained from Eugenia malaccensis seeds as well as the evaluation of its effect in the daily topical treatment of repairing process of cutaneous wounds in mice. The cutaneous wound was produced by the incision of the skin and use of lectin in the treatment of mice cutaneous wounds was evaluated. Surgical wounds were treated daily with a topical administration of EmaL and parameters such as edema, ...
Tópico(s): Essential Oils and Antimicrobial Activity
2012 - Springer Nature | Inflammopharmacology
Produção Nacional
Revisado por pares
Anne Moreira Costa, Cyntia S. Anjos-Duarte, Alzira Kelly Passos Roriz, Vanessa Simões Dias, Iara Sordi Joachim‐Bravo,
Abstract This study evaluated the influence of age and adult nutritional status of Ceratitis capitata males on their ability to inhibit female remating. Their roles and that of copula duration on the amount of sperm transferred to female spermathecae were also analysed. After emergence, adults were kept in separate groups according to their diets (either high protein – 6.5 g of brewer’s yeast, or low protein – 3.5 g of brewer’s yeast) and their age at the time of use in experiments (4, 8, 12, 16 and 20 ...
Tópico(s): Plant and animal studies
2011 - Wiley | Journal of Applied Entomology
Produção Nacional
Revisado por pares
Camila Marques-da-Silva, Mariana M. Chaves, Suzana Passos Chaves, Vanessa Ribeiro Figliuolo, José Roberto Meyer‐Fernandes, Suzana Côrte‐Real, Claudiana Lameu, Henning Ulrich, David M. Ojcius, Bartira Rossi‐Bergmann, Robson Coutinho‐Silva,
Nucleotides are released into the extracellular milieu from infected cells and cells at inflammatory sites. The extracellular nucleotides bind to specific purinergic (P2) receptors and thereby induce a variety of cellular responses including anti-parasitic effects. Here we investigated whether extracellular nucleotides affect leishmanial infection in macrophages, and found that UTP reduces strongly the parasite load in peritoneal macrophages. Ultrastructural analysis of infected cells revealed that ...
Tópico(s): Adolescent and Pediatric Healthcare
2011 - Wiley | Cellular Microbiology
Produção Nacional
Revisado por pares
Vanessa Passos Brustein, C. L. B. Cavalcanti, Mário Ribeiro de Melo-Júnior, Maria Tereza Santos Correia, Eduardo Isidoro Carneiro Beltrão, Luiz Bezerra de Carvalho,
Tópico(s): Cancer Cells and Metastasis
2011 - Springer Science+Business Media | Applied Biochemistry and Biotechnology
Produção Nacional
Revisado por pares
Ricardo A. W. Neves Filho, Cec iacute lia Aguiar da Silva, Cl eacute cia Sipriano Borges da Silva, Vanessa Passos Brustein, Daniela Maria do Amaral Ferraz Navarro, F aacute bio Andr eacute Brayner dos Santos, Luiz Carlos Alves, Mar iacute lia Gabriela dos Santos Cavalcanti, Rajendra Mohan Srivastava, Maria das Gra ccedil as Carneiro-Da-Cunha,
The synthesis of 3-(3-aryl-1,2,4-oxadiazol-5-yl)propionic acids from arylamidoximes and succinic anhydride under focused microwave irradiation conditions is described. The new synthetic method furnished the desired products in 2—3 min and good yields. Furthermore, the previously complicated purification procedure has been simplified in a manner which is quick, eco-friendly and cost-effective. Larvicidal bioassay and fungal growth inhibitory tests were performed using several 3-(3-aryl-1,2,4-oxadiazol- ...
Tópico(s): Fungal Plant Pathogen Control
2009 - Pharmaceutical Society of Japan | Chemical and Pharmaceutical Bulletin
Produção Nacional
Revisado por pares
Daniel Shao-Weng Tan, Enriqueta Felip, Gilberto de Castro, Benjamin Solomon, Alastair Greystoke, Byoungchul Cho, Manuel Cobo, Tae Min Kim, Sandip Ganguly, Enric Carcereny, Luis Paz‐Ares, Jaafar Bennouna, Marina Chiara Garassino, Michael Schenker, Sang‐We Kim, Bijoyesh Mookerje, Vanessa Q. Passos, Stéphanie Deudon, Bharani Dharan, Yuanbo Song, Rafael Caparica, Bruce E. Johnson,
... Garassino, Michael Schenker, Sang-We Kim, Bijoyesh Mookerje, Vanessa Q. Passos, Stephanie Deudon, Bharani Dharan, Yuanbo Song, Rafael Caparica, ...
Tópico(s): Lung Cancer Diagnosis and Treatment
2022 - American Association for Cancer Research | Cancer Research
Produção Nacional
Revisado por pares
Moan Jéfter Fernandes Costa, Caio Alano de Almeida Lins, Louise Passos Vigolvino Macêdo, Vanessa Patrícia Soares de Sousa, Jussaro Alves Duque, Marcelo Cardoso de Souza,
Clinical and self-perceived oral health assessment of elderly
Tópico(s): Dental Research and COVID-19
2019 - Elsevier BV | Clinics
Vivek Subbiah, Robert J. Kreitman, Zev A. Wainberg, Anas Gazzah, Ulrik Lassen, Alexander Stein, Patrick Y. Wen, Sascha Dietrich, Maja J.A. de Jonge, Jean‐Yves Blay, Antoîne Italiano, Kan Yonemori, Daniel C. Cho, Filip De Vos, Philippe Moreau, Elena Élez, Jan H.M. Schellens, Christoph Zielinski, Suman Redhu, Aislyn Boran, Vanessa Q. Passos, Palanichamy Ilankumaran, Yung‐Jue Bang,
Abstract BRAFV600E alterations are prevalent across multiple tumors. Here we present final efficacy and safety results of a phase 2 basket trial of dabrafenib (BRAF kinase inhibitor) plus trametinib (MEK inhibitor) in eight cohorts of patients with BRAFV600E -mutated advanced rare cancers: anaplastic thyroid carcinoma ( n = 36), biliary tract cancer ( n = 43), gastrointestinal stromal tumor ( n = 1), adenocarcinoma of the small intestine ( n = 3), low-grade glioma ( n = 13), high-grade glioma ( n = 45), hairy cell leukemia ( ...
Tópico(s): Cancer-related Molecular Pathways
2023 - Nature Portfolio | Nature Medicine
Produção Nacional
Revisado por pares
Daniel S.W. Tan, Enriqueta Felip, Gilberto de Castro, Benjamin Solomon, Alastair Greystoke, Byoung Chul Cho, Manuel Cobo, Tae Min Kim, Sandip Ganguly, Enric Carcereny, Luis Paz‐Ares, Jaafar Bennouna, Marina Chiara Garassino, Michael Schenker, Sang‐We Kim, Jan C. Brase, Denise Bury-Maynard, Vanessa Q. Passos, Stéphanie Deudon, Bharani Dharan, Yuanbo Song, Rafael Caparica, Bruce E. Johnson,
The addition of checkpoint inhibitors to first-line treatment has prolonged survival of patients with non-small-cell lung cancer (NSCLC), but prognosis remains poor, with new treatment options needed. Canakinumab, a human, monoclonal anti-interleukin (IL)-1β antibody, has potential to enhance the activity of PD-L1 inhibitors and chemotherapy (CT) by inhibiting protumor inflammation.
Tópico(s): Lung Cancer Diagnosis and Treatment
2023 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Youcef Chakib Hacene, Alexis Loiseau, Vanessa Dos Passos Maio, P. Grenier, Élodie Boisselier, Nicolas Bertrand,
Polyethylene glycol (PEG) is considered the gold standard to prepare long circulating nanoparticles. The hydrophilic layer that sterically protects PEGylated nanomedicines also impedes their separation from biological media. In this study, we describe an immunoprecipitation method using AntiPEG antibodies cross-linked to magnetic beads to extract three types of radiolabeled PEGylated systems: polymeric nanoparticles, liposomes, and therapeutic proteins. The potential of the method is emphasized by ...
Tópico(s): Characterization and Applications of Magnetic Nanoparticles
2021 - American Chemical Society | Nano Letters
Pilar Garrido, Jean-Louis Pujol, Edward S. Kim, Jay M. Lee, Masahiro Tsuboi, Ana Gómez‐Rueda, Amparo Benito, Nicolás Moreno‐Mata, Luis Gorospe, Tuochuan Dong, Cecile Blin, Vanessa Rodrik-Outmezguine, Vanessa Q. Passos, Tony Mok,
Canakinumab is a human IgGκ monoclonal antibody, with high affinity and specificity for IL-1β. The Canakinumab Anti-Inflammatory Thrombosis Outcome Study (CANTOS) trial, evaluating canakinumab for cardiovascular disease, provided the first signal of the potential of IL-1β inhibition on lung cancer incidence reduction. Here, we describe the rationale and design for CANOPY-N, a randomized Phase II trial evaluating IL-1β inhibition with or without immune checkpoint inhibition as neoadjuvant treatment ...
Tópico(s): Immunotherapy and Immune Responses
2021 - Future Medicine | Future Oncology
Produção Nacional
Revisado por pares
Byoung Chul Cho, Radka Obermannová, Alessandra Bearz, Mark J. McKeage, Dong-Wang Kim, Ullas Batra, Gloria Borra, Sergey Orlov, Sang-We Kim, Sarayut Lucien Geater, Pieter E. Postmus, Scott A. Laurie, Keunchil Park, Cheng‐Ta Yang, Andrea Ardizzoni, Anna Bettini, Gilberto de Castro, Flavia Kiertsman, Zhe Chen, Yvonne Lau, Kalyanee Viraswami-Appanna, Vanessa Q. Passos, Rafał Dziadziuszko,
In an earlier report of the ASCEND-8 study (open-label, phase I, three-arm study, treatment-naive patients and pre-treated patients with advanced/metastatic NSCLC), it was shown that ceritinib 450 mg with food had comparable exposure and better gastrointestinal tolerability than 750-mg fasted.Here, we report efficacy and updated safety data from primary efficacy analysis of the ASCEND-8 study. Key secondary endpoints were overall response rate and duration of response, assessed by blinded independent ...
Tópico(s): Lung Cancer Research Studies
2019 - Elsevier BV | Journal of Thoracic Oncology
Makoto Nishio, Enriqueta Felip, Sergey Orlov, Keunchil Park, Chong‐Jen Yu, Chun-Ming Tsai, Manuel Cobo, Mark J. McKeage, Wu‐Chou Su, Tony Mok, Giorgio V. Scagliotti, David R. Spigel, Kalyanee Viraswami-Appanna, Zhe Chen, Vanessa Q. Passos, Alice T. Shaw,
The phase II, single-arm ASCEND-3 study assessed the efficacy and safety of ceritinib in anaplastic lymphoma kinase (ALK) inhibitor (ALKi)-naive patients with ALK-rearranged NSCLC who had received at least three previous lines of chemotherapy. Here, we report the final efficacy and safety results.Eligible patients (including those with asymptomatic or neurologically stable brain metastases) received oral ceritinib (750 mg/day, fasted). The primary end point was investigator-assessed overall response ...
Tópico(s): Lung Cancer Diagnosis and Treatment
2019 - Elsevier BV | Journal of Thoracic Oncology
Jan Tack, Jens Aberle, Joris Arts, Martine Laville, Jean‐Michel Oppert, G. Bender, Sunil Bhoyrul, Tracey McLaughlin, T. Yoshikawa, Adrian Vella, Jingwen Zhou, Vanessa Q. Passos, P.R. O'Connell, André P. van Beek,
Summary Background Dumping syndrome is a prevalent complication of oesophageal and gastric surgery characterised by early (postprandial tachycardia) and late (hypoglycaemia) postprandial symptoms. Aim To evaluate efficacy and safety of the somatostatin analogue, pasireotide in patients with dumping syndrome after bariatric or upper gastrointestinal cancer surgery. Methods A single‐arm, open‐label, multicentre, intrapatient dose‐escalation, phase 2 study with 4 phases: screening, 3‐month SC (subcutaneous), ...
Tópico(s): Pituitary Gland Disorders and Treatments
2018 - Wiley | Alimentary Pharmacology & Therapeutics
Byoung Chul Cho, Dong‐Wan Kim, Alessandra Bearz, Scott A. Laurie, Mark J. McKeage, Gloria Borra, Keunchil Park, Sang-We Kim, Marwan Ghosn, Andrea Ardizzoni, Evaristo Maiello, Alastair Greystoke, Richard Yu, Karen A. Osborne, Wen Gu, Jeffrey W. Scott, Vanessa Q. Passos, Yvonne Lau, Anna Wrona,
Tópico(s): Gastric Cancer Management and Outcomes
2017 - Elsevier BV | Journal of Thoracic Oncology
Ying Hong, Vanessa Q. Passos, Pai‐Hsi Huang, Yvonne Lau,
Abstract Ceritinib is a second‐generation selective and potent oral anaplastic lymphoma kinase (ALK) inhibitor approved for ALK‐positive advanced non–small cell lung cancer previously treated with crizotinib. Population pharmacokinetic (PK) analysis was performed to describe the PK of ceritinib and was used to evaluate the covariate effects on systemic exposure at its label dose (750 mg orally once daily). Ceritinib concentration–time data from 4 clinical studies were described by a 1‐compartment model ...
Tópico(s): Cancer therapeutics and mechanisms
2016 - Wiley | The Journal of Clinical Pharmacology
Enriqueta Felip, Sergey Orlov, K. Park, Chong‐Jen Yu, Chun‐Ming Tsai, Makoto Nishio, Manuel Cobo, Mark J. McKeage, Wu‐Chou Su, Tony Mok, Giorgio V. Scagliotti, David R. Spigel, Vanessa Q. Passos, V. Chen, Florence Munarini, Alice T. Shaw,
In the pivotal ASCEND-1 study, ceritinib showed whole body efficacy in ALKi-naïve pts with ALK+ NSCLC (including those with baseline BM), most of whom had received multiple prior therapies; median progression-free survival (mPFS) was 18.4 mo. The ASCEND-3 single-arm, open-label multicentre study evaluated the efficacy and safety of ceritinib in previously treated ALKi-naïve pts with ALK+ NSCLC (NCT01685138). Pts enrolled worldwide received oral ceritinib 750 mg/d (fasted) from 21 Jan 2013. Whole body ...
Tópico(s): Cancer therapeutics and mechanisms
2016 - Elsevier BV | Annals of Oncology
Produção Nacional
Revisado por pares
Paulo M. Hoff, Daniel Fernandes Saragiotto, Carlos H. Barrios, Auro del Giglio, Anelisa K. Coutinho, Aline C Andrade, Carolina Dutra, Nora Manoukian Forones, Mariangela Correa, Maria do Socorro Oliveira Portella, Vanessa Q. Passos, Renata N. Chinen, Brigitte Van Eyll,
Chemotherapy-induced diarrhea (CID) is a relatively common adverse event in the treatment of patients with colorectal cancer. The LAR for Chemotherapy-Induced Diarrhea (LARCID) trial evaluated the efficacy and safety of long-acting release octreotide (octreotide LAR) for the prevention of CID in this population.Patients with colorectal cancer starting adjuvant or first-line treatment with a chemotherapy combination containing fluorouracil, capecitabine, and/or irinotecan were randomly assigned to receive ...
Tópico(s): Gastric Cancer Management and Outcomes
2014 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Produção Nacional
Revisado por pares
Carolina Cristina, Graciela Dı́az-Torga, Rodolfo G. Goya, Sham S. Kakar, María Inés Pérez‐Millán, Vanessa Q. Passos, Daniel Giannella‐Neto, Marcello D. Bronstein, Damasia Becú‐Villalobos,
Abstract Background Pituitary tumor transforming gene (pttg) is a novel oncogene that is expressed at higher level in most of the tumors analyzed to date compared to normal tissues. Nevertheless, its expression in prolactinomas and its relation with the pituitary dopamine receptor 2 (D2R) are not well defined. We sought to determine the pituitary level of pttg in three different experimental models of prolactinomas with altered dopaminergic control of the pituitary: the dopaminergic D2R knockout female ...
Tópico(s): Adrenal and Paraganglionic Tumors
2007 - BioMed Central | Molecular Cancer
Produção Nacional
Cíntia Cercato, Márcio C. Mancini, Ana Maria Carvalho Arguello, Vanessa Q. Passos, S M Villares, Alfredo Halpern,
OBJECTIVE: To determine the prevalence of systemic hypertension, diabetes mellitus, hypercholesterolemia, and hypertriglyceridemia in a Brazilian population in relation to body mass index. METHOD: Retrospective evaluation of 1213 adults (mean age: 45.2 ± 12.8; 80.6% females) divided into groups according to body mass index [normal (18.5 - 24.4 kg/m²); overweight (25 - 29.9 kg/m²); grade 1 obesity (30 - 34.9 kg/m²); grade 2 obesity (35 - 39.9 kg/m²), and grade 3 obesity (> 40 kg/m²)]. The prevalence of hypertension, ...
Tópico(s): Diet and metabolism studies
2004 - Universidade de São Paulo - FM/USP | Revista do Hospital das Clínicas
Produção Nacional
Revisado por pares
Vanessa Q. Passos, Jean Jorge Silva de Souza, Nina Rosa Castro Musolino, Marcello D. Bronstein,
Bromocriptine (BRC) and other dopamine agonist drugs are the first-choice treatment for prolactinomas. However, the major disadvantage is the need for prolonged therapy. We retrospectively studied 131 patients [62 microprolactinoma (MIC), 69 macroprolactinoma (MAC)], who achieved serum prolactin (PRL) normalization during BRC use. Twenty-seven percent of them (31% MIC and 69% MAC) underwent previous surgery. Twenty-seven patients (20.6%: 25.8% MIC and 15.9% MAC) persisted with normoprolactinemia after ...
Tópico(s): Growth Hormone and Insulin-like Growth Factors
2002 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism
Produção Nacional
Revisado por pares
Vanessa Q. Passos, Maria Angela Henriques Zanella Fortes, Daniel Giannella‐Neto, Marcello D. Bronstein,
<i>Background/Aims:</i> Prolactin (PRL) secretion and its gene expression are inhibited by dopamine. Prolactinomas are the most common secreting pituitary adenomas, and dopamine agonists (DA) are the first choice for their treatment. However, a subset of patients is resistant to DA. As the mechanisms involved in DA resistance are not fully understood, the aim of this study was to obtain new insights regarding the molecular differences between the prolactinomas that are responsive to DA ...
Tópico(s): Adrenal and Paraganglionic Tumors
2008 - Karger Publishers | Neuroendocrinology
Produção Nacional
Joice Valentim, Vanessa Q. Passos, Fábio Mataveli, Alessandra Calabró,
This study aims to compare economic and patient impacts of the treatment of acromegaly with two different somatostatin analogues (octreotide LAR and lanreotide SR) in Brazil. A cost-effectiveness analysis was carried out under the Brazilian Public Health Care System (SUS) perspective. A decision analytical model was developed based on the Brazilian Public Health Care System Clinical Guideline for Acromegaly. A hypothetical cohort of 276 patients was followed for two years. Data were extracted from ...
Tópico(s): Ophthalmology and Eye Disorders
2008 - Editora da Universidade de São Paulo | Arquivos Brasileiros de Endocrinologia & Metabologia
Produção Nacional
Revisado por pares
Renato M. Passos, Alexandre B. Sé, Vanessa L. Wolff, Yanna Karla de Medeiros Nóbrega, Marcelo Hermes‐Lima,
In this article, we report on an experiment designed to improve the learning of metabolic biochemistry by nutrition and medical undergraduate students. Twelve students participated in a monitored lunch and had their blood extracted for analysis 1) before lunch, 2) 30 min after lunch, and 3) 3 h after lunch. The subjects were divided in two groups. One group had a hyperglicidic meal [pasta plus orange juice: 80% carbohydrate, 10% protein, and 10% lipid (estimated values)] and the other group had a ...
Tópico(s): Metabolism and Genetic Disorders
2006 - American Physical Society | AJP Advances in Physiology Education