Ronald L. Klein, Robert D. Dayton, Tracee Terry, Chris Vascoe, John J. Sunderland, Kerrie H. Tainter,
We attempted to monitor the nigrostriatal dopaminergic system in rats with positron emission tomography (PET) during the progression of two experimental disease states. One model was 6-hydroxydopamine (6-OHDA) lesioning and the other was direct gene transfer of the microtubule-associated protein tau to the substantia nigra using an adeno-associated virus vector (AAV9). The PET ligand was 6-[18F]fluoro-L-m-tyrosine (FMT), imaged prior to, and at two intervals after initiating dopaminergic neurodegeneration. ...
Tópico(s): RNA regulation and disease
2009 - Elsevier BV | Brain Research
... deal of time sitting around in her underwear." Vascoe"?her husband?"was so ashamed of me!"I ... to a farm near Tifton, in south Georgia.Vascoe?he usu ally signed his name "V.J.," ...
Tópico(s): Race, History, and American Society
2007 - University of Iowa | The Iowa Review
Oleksandr Ekshyyan, Don A. Sibley, Gloria Caldito, John J. Sunderland, Chris Vascoe, Cherie‐Ann O. Nathan,
Abstract Objectives/Hypothesis: The early detection of persistent/recurrent disease of head and neck squamous cell carcinoma (HNSCC) after treatment can be challenging. The currently used radioisotope 18 F‐fluorodeoxyglucose (FDG) is a nonspecific tracer for cancer cells as it detects all metabolically active cells including inflammation. 18 F‐fluorodeoxythymidine (FLT) is a radioactive tracer for rapidly proliferating cells, and therefore is more specific for detecting cancer. Our aim was to compare ...
Tópico(s): Cancer Research and Treatments
2012 - Wiley | The Laryngoscope