A.G. Secchi, Vavara Grigoriou, Irving M. Shapiro, Elisabetta Ada Cavalcanti‐Adam, Russell J. Composto, Paul Ducheyne, Christopher S. Adams,
Abstract A major cause of implant failure in skeletal tissues is failure of osseointegration, often due to lack of adhesion of cells to the titanium (Ti) alloy interface. Since arginine‐glycine‐aspartic acid (RGD)‐containing peptides have been shown to regulate osteoblast adhesion, we tested the hypothesis that, bound to a Ti surface, these peptides would promote osteoblasts differentiation, while at the same time inhibit apoptosis. RGDS and RGES (control) peptides were covalently linked to Ti discs ...
Tópico(s): Titanium Alloys Microstructure and Properties
2007 - Wiley | Journal of Biomedical Materials Research Part A
Vavara Grigoriou, Irving M. Shapiro, Elisabetta Ada Cavalcanti‐Adam, Russell J. Composto, Paul Ducheyne, Christopher S. Adams,
We tested the hypothesis that RGDS peptides regulate osteoblast survival in culture. Osteoblast-like MC3T3-E1 cells were allowed to attach to RGDS peptides that had been tethered to a silicone surface utilizing a previously described grafting technique. The RGDS-modified surface caused up-regulation of αvβ3 integrin. We noted that there was an increase in expression of activated focal adhesion kinase and activated Akt. There was no change in the expression level of the anti-apoptotic protein Bcl- ...
Tópico(s): Bone Metabolism and Diseases
2004 - Elsevier BV | Journal of Biological Chemistry
Tatjana F. Bivol, Vavara F. Ignat, Elena A. Kukurusak, H. Kegler,
Tópico(s): Powdery Mildew Fungal Diseases
1987 - Taylor & Francis | Archives of Phytopathology and Plant Protection