Adriana S. Veleiro, Lautaro D. Álvarez, Silvina L. Eduardo, Gerardo Burton,
... That Can Adapt to Different Ligands Adriana S. Veleiro Prof., Adriana S. Veleiro Prof. Departamento de Química Orgánica and UMYMFOR (CONICET- ... for more papers by this author Adriana S. Veleiro Prof., Adriana S. Veleiro Prof. Departamento de Química Orgánica and UMYMFOR (CONICET- ...
Tópico(s): Inflammatory mediators and NSAID effects
2010 - Wiley | ChemMedChem
Adriana S. Veleiro, Gerardo Burton, Gloria M. Bonetto, Roberto R. Gil, Juan C. Oberti,
... RETURN TO ISSUEPREVArticleNEXTNew Withanolides from Salpichroa origanifoliaAdriana S. Veleiro, Gerardo Burton, Gloria M. Bonetto, Roberto R. Gil, ...
Tópico(s): Pharmacological Effects of Medicinal Plants
1994 - American Chemical Society | Journal of Natural Products
Gloria M. Bonetto, Roberto R. Gil, Juan C. Oberti, Adriana S. Veleiro, Gerardo Burton,
... Roberto R. Gil, Juan C. Oberti, Adriana S. Veleiro, and Gerardo BurtonCite this: J. Nat. Prod. 1995, ...
Tópico(s): Phytochemicals and Medicinal Plants
1995 - American Chemical Society | Journal of Natural Products
A. Rosado, Gabriela Cantó, Beatriz Veleiro, Julia Rodríguez,
... Repeated Injections of IohexolAna Rosado, Gabriela Canto, Beatriz Veleiro and Julia RodríguezAudio Available | Share
Tópico(s): Herpesvirus Infections and Treatments
2001 - American Roentgen Ray Society | American Journal of Roentgenology
Adriana S. Veleiro, Gerardo Burton, Eduardo G. Gros,
From Acnistus breviflorus the new 27-hydroxy-5β,6β-epoxy-1-oxo-(22R)-witha-24-enolide (2,3-dihydrojaborosalactone A) as well as seven known withanolides, withaferin A, 2,3-dihydrowithaferin A, 6α-chloro-5β-hydroxywithaferin A, 5,6-deoxywithaferin A, jaborosalactone A, jaborosalactone D and jaborosalactone E were isolated and characterized by means of spectroscopic (1H NMR, 13 C NMR and mass spectral) methods. Depending on the extraction solvent (methanol or ethanol), a known artifact (3β-methoxy-2,3- ...
Tópico(s): Phytochemicals and Medicinal Plants
1985 - Elsevier BV | Phytochemistry
Adriana S. Veleiro, Gerardo Burton,
The term “neuroactive steroid” (NAS) refers to steroids which, independent of their origin, are capable of modifying neural activities. These steroids positively or negatively modulate the function of members of the ligand-gated ion channel superfamily. Those with positive allosteric actions on the γ-amino butyric acid type A receptor (GABAA receptor) have been shown to be potent anticonvulsants, anxiolytics, and antistress agents and to possess sedative, hypnotic, and anesthetic activities. New types ...
Tópico(s): Synthesis of heterocyclic compounds
2009 - Bentham Science Publishers | Current Medicinal Chemistry
Adalı́ Pecci, Lautaro D. Álvarez, Adriana S. Veleiro, Nora R. Ceballos, Carlos P. Lantos, Gerardo Burton,
Antiglucocorticoids that act as antagonists at the glucocorticoid receptor (GR) level may be used to block or modulate the undesirable effects of glucocorticoid excess (from endogenous or exogenous origin). RU486 developed in the early 80s, is an antiglucocorticoid but also a potent antiprogestin and abortifacient, nevertheless it still remains as the only GR antagonist drug in the market. Further on, in view of the variety of physiological processes in which glucocorticoids are involved, selective ...
Tópico(s): Cytokine Signaling Pathways and Interactions
2009 - Elsevier BV | The Journal of Steroid Biochemistry and Molecular Biology
Adriana S. Veleiro, Juan C. Oberti, Gerardo Burton,
From Salpichroa origanifolia plants, a new withanolide (20S,22R,24S,25S,26R)-5,6α: 22,26: 24,25-triepoxy-26-hydroxy-17(13 → 18)abeo-5α-ergosta-2,13,15,17-tetraen-1-one was isolated and characterized by spectroscopic and chemical methods.
Tópico(s): Phytochemistry and Bioactive Compounds
1992 - Elsevier BV | Phytochemistry
Rosana I. Misico, Lynda L. Song, Adriana S. Veleiro, Adriana M. Cirigliano, M. Cristina Tettamanzi, Gerardo Burton, Gloria M. Bonetto, Viviana E. Nicotra, Gloria L. Silva, Roberto R. Gil, Juan C. Oberti, A. Douglas Kinghorn, John M. Pezzuto,
Thirty-seven naturally occurring withanolides (1−37), previously isolated in our laboratories, were evaluated for their potential to induce quinone reductase with cultured murine hepatoma cells (Hepa 1c1c7). Spiranoid (29, 32) and 18-functionalized withanolides (2−5, 7−9, 24) were found to be potent inducers of the enzyme, while 5α-substituted derivatives exhibited weak activity. Preliminary studies were performed with compound 29 to evaluate enzyme-inducing capacity in multiple organ sites of BALB/ ...
Tópico(s): Ethnobotanical and Medicinal Plants Studies
2002 - American Chemical Society | Journal of Natural Products
Adriana M. Cirigliano, Adriana S. Veleiro, Juan C. Oberti, Gerardo Burton,
Six new spiranoid withanolides, (20R,22R,23S)-5α-chloro-6β,12β,17β,22-tetrahydroxy-1-oxo-12,23-cycloergosta-2,24-dien-26,23-olide (2), (20R,22R,23S)-5β,6β-epoxy-12β,17β,22-trihydroxy-1-oxo-12,23-cycloergosta-2,24-dien-26,23-olide (3), (20R,22R,23S)-5β,6β-epoxy-4β,12β,17β,22-tetrahydroxy-1-oxo-12,23-cycloergosta-2,24-dien-26,23-olide (4), (20R,22R,23S)-5α,6β,12β,17β,22-pentahydroxy-1-oxo-12,23-cycloergosta-2,24-dien-26,23-olide (5), (20R,22R,23S)-6β,12β,17β,22-tetrahydroxy-5α-methoxy-1-oxo-12,23-cycloergosta- ...
Tópico(s): Pharmacological Effects of Medicinal Plants
2002 - American Chemical Society | Journal of Natural Products
Adriana S. Veleiro, Ruth E. Rosenstein, Carolina O. Jaliffa, Marı́a L Grilli, Florencia Speroni, Gerardo Burton,
3α-Hydroxy-6,19-oxidopregn-4-ene-20-one (4) was prepared in seven steps from pregnanolone acetate. At 0.1 μM concentration 4 significantly increased GABA induced 36Cl− influx in hamster cerebral cortex synaptoneurosomes while at 20 mg/kg it decreased the percentage of hamsters showing seizures induced by 3-mercaptopropionic acid.
Tópico(s): Oxidative Organic Chemistry Reactions
2003 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
Lautaro D. Álvarez, Marcelo A. Martí, Adriana S. Veleiro, Diego M. Presman, Darío A. Estrı́n, Adalı́ Pecci, Gerardo Burton,
21-Hydroxy-6,19-epoxyprogesterone (21OH-6,19OP) is a selective antiglucocorticoid that lacks the bulky substituent at C-11 found in active antagonists of the glucocorticoid receptor (GR). Ligand-free GR ligand-binding domain (LBD) and GR LBD complexed with 21OH-6,19OP or the agonist dexamethasone were simulated during 6 ns using molecular dynamics. Results suggest that the time fluctuation and average position adopted by the H1−H3 loop affect the ability of GR LBD-21OH-6,19OP complex to homodimerize, ...
Tópico(s): Inflammatory mediators and NSAID effects
2008 - American Chemical Society | Journal of Medicinal Chemistry
Lautaro D. Álvarez, Marcelo A. Martí, Adriana S. Veleiro, Rosana I. Misico, Darío A. Estrı́n, Adalı́ Pecci, Gerardo Burton,
The introduction of a hemisuccinate group at the 21-position of the passive antiglucocorticoid 21OH-6,19OP leads to a compound (21HS-6,19OP) with a notable activity profile toward the glucocorticoid receptor (GR). In contrast to the parent steroid, 21HS-6,19OP behaves as a pure agonist of GR activity in direct transactivation assays. However, the apoptotic effects of 21HS-6,19OP show that the effect depends on cell type: while 21HS-6,19OP is a pure agonist in L929 mouse fibroblasts, in thymocytes ...
Tópico(s): Steroid Chemistry and Biochemistry
2008 - Wiley | ChemMedChem
Diego M. Presman, Lautaro D. Álvarez, Valeria Levi, Silvina L. Eduardo, Michelle A. Digman, Marcelo A. Martí, Adriana S. Veleiro, Gerardo Burton, Adalı́ Pecci,
Background The glucocorticoid receptor (GR) is a transcription factor that regulates gene expression in a ligand-dependent fashion. This modular protein is one of the major pharmacological targets due to its involvement in both cause and treatment of many human diseases. Intense efforts have been made to get information about the molecular basis of GR activity. Methodology/Principal Findings Here, the behavior of four GR-ligand complexes with different glucocorticoid and antiglucocorticoid properties ...
Tópico(s): Hormonal Regulation and Hypertension
2010 - Public Library of Science | PLoS ONE
Rubén P. Machín, Adriana S. Veleiro, Viviana E. Nicotra, Juan C. Oberti, José M. Padrón,
The in vitro antiproliferative activity of a series of 22 naturally occurring withanolides was examined against the T-47D, MCF7, MCF7/BUS, MDA-MB-231, and SK-Br-3 human solid tumor breast cancer cell lines. The most active compound showed GI(50) values in the range 0.16-0.71 muM. The aromatic withanolide 19 exhibited specific activity for the estrogen-receptor-positive cell lines (T-47D, MCF7, and MCF7/BUS). Overall, the results demonstrated the relevance of the substitution pattern on the A and ...
Tópico(s): Computational Drug Discovery Methods
2010 - American Chemical Society | Journal of Natural Products
Lisa B. Thorell, Alberto Veleiro, Angela F. Y. Siu, Hiwa Mohammadi,
The present study investigated the relation between academic performance and ratings of executive functioning in children aged 6–11 from four countries: Sweden, Spain, Iran, and China. Ratings of executive functioning were made by both parents and teachers using the Childhood Executive Functioning Inventory (CHEXI). The results showed that the Chinese sample was generally rated as having more executive deficits compared to the other samples. The finding that executive functioning deficits are exacerbated ...
Tópico(s): Cognitive Abilities and Testing
2012 - Taylor & Francis | Child Neuropsychology
Adriana S. Veleiro, Adalı́ Pecci, María Monteserín, Ricardo Baggio, M.T. Garland, Carlos P. Lantos, Gerardo Burton,
Sulfur-bridged pregnanes 6,19-epithioprogesterone, 21-hydroxy-6,19-epithioprogesterone, and the corresponding sulfoxides and sulfones were synthesized and tested as blockers of the immunosuppresive activity of dexamethasone in rat thymocytes. A new one-pot procedure is described for the preparation of 6,19-epithioprogesterone and related compounds by iodocyclization of a 19-sulfanylpregn-5-ene. Antiimmunosuppresive activity was evaluated by the ability of the different steroids to block dexamethasone- ...
Tópico(s): Genomics, phytochemicals, and oxidative stress
2005 - American Chemical Society | Journal of Medicinal Chemistry
Adriana S. Veleiro, Juan C. Oberti, Gerardo Burton,
Since the isolation of withaferin A in 1965 over 300 withanolides have been described, largely from genera belonging to the Solanaceae. Although until the mid eighties most of the withanolides appeared to adhere to the basic structure of withaferin A, nowadays a considerable number of withanolides and withanolide related compounds are known, which present modified skeletons, aromatic rings, additional rings, etc., posing challenging problems of structure elucidation. Many of these structures coexist ...
Tópico(s): Phytochemicals and Medicinal Plants
2005 - Elsevier BV | Studies in natural products chemistry
Adriana M. Cirigliano, Adriana S. Veleiro, Gloria M. Bonetto, Juan C. Oberti, Gerardo Burton,
From the aerial parts of Jaborosa runcinata six new withanolides were isolated and named jaborosalactones 1−6 (1−6). All contain a side chain with a carbon−carbon bond between C-12 of the intact steroid nucleus and C-23 and a spiranoid γ-lactone at the latter position. The additional ring thus formed has a 17(20)-ene-22-keto system. Jaborosalactones 4−6 (4−6) also contain a hydroxyl group at C-21. From the aerial parts of Jaborosa araucana were isolated the known withanolides trechonolide A (8), its ...
Tópico(s): Pharmacological Effects of Medicinal Plants
1996 - American Chemical Society | Journal of Natural Products
Silvina Graciela Bado, Graciela Mareggiani, Nicolás Oscar Amiano, Gerardo Burton, Adriana S. Veleiro,
Biological effects on Ceratitis capitata were evaluated for several withanolides isolated from Salpichroa origanifolia (Solanaceae), (20S,22R,24S,25S,26R)-5α,6α:22,26:24,25-triepoxy-26-hydroxy-17(13→18)-abeo-ergosta-2,13,15,17-tetraen-1-one (salpichrolide A, 1), (20S,22R,24S,25S,26R)-22,26:24,25-diepoxy-5α,6β,26-trihydroxy-17(13→18)-abeo-ergosta-2,13,15,17-tetraen-1-one (salpichrolide C, 2), (20S,22R,24S,25S,26R)-5α,6α;22,26:24,25-triepoxy-15,26-dihydroxy-17(13→18)abeo-ergosta-2,13,15,17-tetraen-1-one ( ...
Tópico(s): Essential Oils and Antimicrobial Activity
2004 - American Chemical Society | Journal of Agricultural and Food Chemistry
Graciela Mareggiani, María Inés Picollo, Eduardo Zerba, Gerardo Burton, M. Cristina Tettamanzi, Miriam O. V. Benedetti-Doctorovich, Adriana S. Veleiro,
The antifeedant effect of several salpichrolides on larvae of Musca domestica was investigated. Three naturally occurring compounds, salpichrolide A (1), salpichrolide C (2), and salpichrolide G (3), previously isolated from Salpichroa origanifolia, and two known (4, 6) and three new (5, 7, 8) synthetic analogues were tested. The maximal effect on development was observed for salpichrolide A (1), while salpichrolide G (3) was the most toxic. The content of the salpichrolides in S. origanifolia was monitored ...
Tópico(s): Complementary and Alternative Medicine Studies
2000 - American Chemical Society | Journal of Natural Products
Rosana I. Misico, Roberto R. Gil, Juan C. Oberti, Adriana S. Veleiro, Gerardo Burton,
Eight new withanolides were isolated from the aerial parts of Vassobia lorentzii and characterized by spectroscopic methods and with the aid of molecular modeling. The compounds were identified as (17S,20R,22R)-5β,6β:18,20-diepoxy-18-hydroxy-1-oxowitha-2,5,24-trienolide (1); (17S,20R,22R)-18,20-epoxy-4β,18-dihydroxy-1-oxowitha-2,5,24-trienolide (2); (17S,18R,20R,22R)-4β-hydroxy-18,20-epoxy-18-methoxy-1-oxowitha-2,5,24-trienolide (3); (17S,18S,20R,22R)-4β-hydroxy-18,20-epoxy-18-methoxy-1-oxowitha-2,5,24- ...
Tópico(s): Heavy metals in environment
2000 - American Chemical Society | Journal of Natural Products
Lucía Alvela-Suárez, Virgínia Velasco-Tirado, Moncef Belhassen‐García, Ignacio Novo‐Veleiro, Javier Pardo‐Lledías, Ángela Romero‐Alegría, Luis Villar, María Paz Valverde-Merino, Miguel Cordero-Sánchez,
There is still no well-established consensus about the clinical management of hydatidosis. Currently, surgery continues to be the first therapeutic option, although treatment with anti-parasitic drugs is indicated as an adjuvant to surgery to decrease the number of relapses and hydatid cyst size. When surgery is not possible, medical treatment is indicated. Traditionally, albendazole was used in monotherapy as the standard treatment. However, combined therapy with albendazole plus praziquantel appears ...
Tópico(s): Parasites and Host Interactions
2014 - American Society of Tropical Medicine and Hygiene | American Journal of Tropical Medicine and Hygiene
María Pedrosa, A. Prieto, Anna Sala, Teresa Caballero, M. L. Baeza, Rosario Cabañas, Angélica Cristine de Almeida Campos, Stefan Cimbollek, Carmen Gómez‐Traseira, Teresa González-Quevedo, Mar Guilarte, Jesús Jurado‐Palomo, T Lobera, M C López-Serrano, Concepción de Frutos-de Marcos, Macarena Piñero-Saavedra, Nieves Prior, B. Sáenz de San Pedro, Marta Ferrer, J. M. Barceló, Álvaro Daschner, M. Echechipía, Moisès Garcés, P. Iriarte, I Jáuregui, M. Lázaro, Miguel A. Quiñones, Beatriz Veleiro, O Villareal,
Angioedema refers to a localized, transient swelling of the deep skin layers or the upper respiratory or gastrointestinal mucosa. It develops as a result of mainly two different vasoactive peptides, histamine or bradykinin. Pathophysiology, as well as treatment, is different in each case; nevertheless, the resulting signs and symptoms may be similar and difficult to distinguish. Angioedema may occur at any location. When the affected area involves the upper respiratory tract, both forms of angioedema ...
Tópico(s): Mast cells and histamine
2014 - Informa | Annals of Medicine
Ignacio Novo‐Veleiro, Rogelio González‐Sarmiento, Clara Cieza-Borrella, I. Pastor, F.J. Laso, Miguel Marcos,
Polymorphisms in the microRNA (miRNA) regulatory pathways are novel functional genetic variants whose association with alcoholism susceptibility has not been previously studied. Given the potential relationship between certain miRNAs and alcohol use disorders (AUDs), this study was designed to explore the association between two polymorphisms within hsa-miR-146a and hsa-miR-196a2 genes and susceptibility to these diseases.Three hundred and one male patients with AUDs and 156 sex-matched healthy volunteers ...
Tópico(s): Circular RNAs in diseases
2014 - Cambridge University Press | European Psychiatry
Ignacio Novo‐Veleiro, Cristina de la Calle, Susana Domínguez-Quibén, Isabel Pastor, Miguel Marcos, F.J. Laso,
Aims: Prevalence of chronic hepatitis C virus (HCV) infection among alcoholics is thought to be higher than in the general population, although prevalence rates reported are quite variable. Our study is aimed to analyze HCV prevalence in a cohort of alcoholics and to perform a systematic review on this topic. Patients and methods: A total of 396 alcoholic patients consecutively referred to our Alcoholism Unit were included. HCV infection status and other clinical variables were recorded for each ...
Tópico(s): Hepatitis B Virus Studies
2013 - Oxford University Press | Alcohol and Alcoholism
M. Cristina Tettamanzi, Adriana S. Veleiro, Juana R. de la Fuente, Gerardo Burton,
Five new withanolides, 5 alpha,6 alpha:22,26:24,25-triepoxy-16 alpha,26-dihydroxy-18(13-->17)-abeo-ergosta-2,13-dien-1-one (salpichrolide N, 1), 5 alpha,6 alpha:22,26:24,25-triepoxi-15 alpha,26-dihydroxyergosta-2,16-dien-1-one (salpichrolide L, 2), 5 alpha,6 alpha:22,26-diepoxi-24,25,26-trihydroxy-17(13-->18)-abeo-ergosta-2,13,15,17-tetraen-1-one (salpichrolide M, 3a), 5 alpha,6 alpha:22,25:22,26-triepoxy-24-hydroxy-17(13-->18)-abeo-ergosta-2,13,15,17-tetraen-1-one (salpichrolide J, 4), and 5 alpha, ...
Tópico(s): Phytochemicals and Medicinal Plants
2001 - American Chemical Society | Journal of Natural Products
Graciela Mareggiani, María Inés Picollo, Adriana S. Veleiro, M. Cristina Tettamanzi, Miriam O. V. Benedetti-Doctorovich, Gerardo Burton, Eduardo Zerba,
Biological effects on Tribolium castaneum larvae were evaluated for three withanolides isolated from Salpichroa origanifolia (Solanaceae), (20S,22R,24S,25S,26R)-5α,6α:22,26:24,25-triepoxy-26-hydroxy-17(13→18)-abeo-ergosta-2,13,15,17-tetraen-1-one (salpichrolide A, 1), (20S,22R,24S,25S,26R)-22,26:24,25-diepoxy-5α,6β,26-trihydroxy-17(13→18)-abeo-ergosta-2,13,15,17-tetraen-1-one (salpichrolide C, 2), and (20S,22R,24S,25S,26R)-5α,6α:22,26:24,25-triepoxy-15,26-dihydroxy-17(13→18)-abeo-ergosta-2,13,15,17-tetraen- ...
Tópico(s): Pharmacological Effects of Medicinal Plants
2001 - American Chemical Society | Journal of Agricultural and Food Chemistry
Juan González‐Fernández, Beatriz Veleiro, Álvaro Daschner, Carmen Cuéllar,
Vertebrate tropomyosins are generally not allergenic, with the only exception being tilapia tropomyosin. [1] Liu R. Holck A.L. Yang E. Liu C. Xue W. Tropomyosin from tilapia (Oreochromis mossambicus) as an allergen. Clin Exp Allergy. 2013; 43: 365-377 Crossref PubMed Scopus (70) Google Scholar With a special workup of a patient with fish-induced symptoms, we found that several vertebrate tropomyosins can be allergenic.
Tópico(s): Allergic Rhinitis and Sensitization
2015 - Elsevier BV | Annals of Allergy Asthma & Immunology
Alcohol consumption and hepatitis C virus (HCV) infection have a synergic hepatotoxic effect, and the coexistence of these factors increases the risk of advanced liver disease.The main mechanisms of this effect are increased viral replication and altered immune response, although genetic predisposition may also play an important role.Traditionally, HCV prevalence has been considered to be higher (up to 50%) in alcoholic patients than in the general population.However, the presence of advanced alcoholic ...
Tópico(s): Alcohol Consumption and Health Effects
2016 - Baishideng Publishing Group | World Journal of Gastroenterology