Andrew Robson, John Welford, Phil Yates, Ann Sieghart, Jon Ashworth, Raymond Snoddy Media Editor, Helen Studd, Jonathan Radgick, Robert Cole, Andrew Pierce, DJM, Ed Maria, Chris Ward, James Moore, Adam Sherwin Media Reporter, Roger Maynard and Frances Gibb, Frances Gibb Legal Editor, Diana Wildman, David Wilson, Tessa Jowell, James Moore and Christine Buckley, Philip Howard, Hilary Finch, Marcus Gheeraerts II, David Chater, Rachel Campbell-Johnston, Penny Wark, Nic Hopkins, Patricia Hewitt, Carl Mortished, Joseph Roth, Sam Marlowe, Thos: Whipham, James Eve, Joanne Harris, Raymond Snoddy, Sam Lister, Joe Joseph, Ben Webster Transport Correspondent, John Mortimer, David McVay, Patrick Caulfield, Stewart Tendler Crime Correspondent, Jennai Cox Fitness Editor, Steve Bird, James W. Thirsk, Elizabeth Bishop, Cedric Morris and Lett Haines, Michael Hofmann, Daniel Finkelstein, Ruth Gledhill Religion Correspondent, Dalya Alberge Arts Correspondent, Dan Sabbagh, Richard Ford Home Correspondent, Stephen Aries, Alan Hamilton, Nicolas Potter, Amanda Loose, Eve-Ann Prentice, Gerald Mortimer, Jeremy Harris, Sue Corbett, Roland Watson, Richard Lloyd Parry, David Hands, Malika Browne, Mark Souster and David Hands, Anthea Lawson, Mark Court, Barbara Dorf, Hugo Rifkind, Bob Woodward, Angela Jameson, Roger Scruton, Russell Kempson, Hugh Lupton, David Rowan, Vanora Bennett, Tony Halpin Education Editor, Tony Steele, Oliver Kay, David Bage, David Adams Latin America Correspondent, Lisa Armstrong, Rick Broadbent, Tom Baldwin, John Hopkins, Karen Homer, Simon de Bruxelles, Alison Roberts, Lisa Clifford and Paula Hawkins, Geoffrey Dean, Rob Wright, Abigail Rayner and Caroline Merrell, David Charter and Peter Riddell, Roland Watson and Rory Watson, Neil Harman Tennis Correspondent, Dan Sabbagh Telecoms Correspondent, Kate Pettifer, Raymond Keene, John Russell Taylor, Malcolm Rees (Lecturer), Rosemary Bennett Deputy Political Editor, Xan Rice, Russell Hotten, Christopher Martin-Jenkins Chief Cricket Correspondent, Roger Boyes, Simon Sellick, Nick Hasell, Peter Dixon, Nigel Holmes, Sandy Skinner, David Hands Rugby Correspondent, John Allison, Anne Ashworth, John Goodbody, Dominic Kennedy, Nick Szczepanik, W. W. Norton, Philip Webster Political Editor, Melissa Kite Political Correspondent, Tim Hames, Ian Johns, Gerald Grainge, George Caulkin, Russell Jenkins, Alan Lee, Denis Jackson, Peter Riddell, Lea Paterson Economics Editor, Jeremy Hart, Michael Gove, Jerrold Maycock, Ben Webster, James Bone and Michael Evans, David Charter Chief Political Correspondent, Richard Beeston Diplomatic Editor, Cecil Duckworth, Jack Malvern Arts Reporter, Ian Whittell, Simon Jenkins, Annabelle Thorpe, Gary Duncan Economics Correspondent, Catherine Philp, Chris Ayres, James Jackson, Alan Coren, Emma Hartley, Ashling O'Connor, Benedict Nightingale, Stephen Dalton, Elizabeth Blackadder, James Christopher, Abigail Rayner, Ben MacIntyre Political Sketch, Michael Evans, Frank Field, Alan Lee Racing Correspondent, Richard Lethbridge, Anthony Browne and Melissa Kite, Edward Gorman Sailing Correspondent, Colin McQuillan, Sabrina Wolfe, Gillian Harris Scotland Correspondent and Patrick Barkham, Janine di Giovanni, Christopher Irvine, David Ponte,
... agent accuses troubled Venables while Bergkamp reconsiders retirement Mancini makes Lazio almost loveable Letter from Rome Arsenal ...
2002 - Gale Group | TDA
Diala Kantar, Emilie Bousquet Mur, Maicol Mancini, Věra Slaninová, Yezza Ben Salah, Luca Costa, Elodie Forest, Patrice Lassus, Charles Géminard, Florence Boissière‐Michot, Béatrice Orsetti, Charles Theillet, Jacques Colinge, Christine Bénistant, Antonio Maraver, Lisa Héron‐Milhavet, Alexandre Djiane,
Abstract Alterations to cell polarization or to intercellular junctions are often associated with epithelial cancer progression, including breast cancers (BCa). We show here that the loss of the junctional scaffold protein MAGI1 is associated with bad prognosis in luminal BCa, and promotes tumorigenesis. E-cadherin and the actin binding scaffold AMOTL2 accumulate in MAGI1 deficient cells which are subjected to increased stiffness. These alterations are associated with low YAP activity, the terminal ...
Tópico(s): Ubiquitin and proteasome pathways
2021 - Nature Portfolio | Scientific Reports
Jeremy Andrews, Edward Gorman Irish Affairs Correspondent, Frances Gibb, Legal Affairs Correspondent, Juan Carlos Gumucio, Michael Knipe Diplomatic Correspondent, Nicholas Wood, Political Correspondent, Patricia Davies, Simon Barnes, D. E. G. Plowman, Andrew Longmore, Christopher Derrick, Neil Bennett, Gordon Allan, Joe Joseph and Derek Harris, David Rhys Jones, Sheridan Morley, Douglas Broom, Education Reporter, Angela MacKay, Michael Stevenson, Michael Seely, Racing Correspondent, David Gower, Philip Howard, John Bell, City Editor, Hilary Finch, Denis Young, G. Christopher Anderson, George Schöpflin, Mandarin (Michael Phillips), Carol Leonard, Richard Streeton, Melinda Wittstock and Neil Bennett, Mario Modiano, Gerald Davies, George Clinton, Lindsay Cook, Family Money Editor, David Sapsted, David Cross and Pearce Wright, Mitchell Platts, Golf Correspondent, Nicholas Wood Political Correspondent, Alan Lorimer, Pearce Wright Science Editor, Peter Waymark, Stewart Tendler, Philip Webster and Richard Ford, Robin Young, Barry Sheen, Michael Clark, Thomson Prentice, Science Correspondent, Kevin Eason Motoring Correspondent, David Hands, Ray Robinson, Mark Souster and Michael Dynes, Stanley Matthews, Conor Cruise O'Brien, Frank Perryman, Ian Dunlop, Nigel Williamson, K. R. Wing (Director), Andrew Gibbon Williams, Gavin Bell, G. R. Harrison, John Woodcock, David Cross, Robert Kirley, Sydney Friskin, Nigel Williamson and Michael Knipe, Tim Jones Employment Affairs Correspondent, Robin Oakley Political Editor, Anthony Dykes, Philip Webster, Chief Political Correspondent, Alan Orme, Gillian Bowditch, Sam Parkhouse, Josephine Fairley, Rodney Bewes, Robin Oakley, Political Editor, David Powell Athletics Correspondent, Peter Davalle, Simon Tait Arts Correspondent, John Russell Taylor, Barbara Amiel, Raymond Keene, Chess Correspondent, Wendy Cooper, Paul Griffiths, Peter Bryan, Barrie Gill, Richard Evans, Mark Herbert, Ernest Beck-Budapest, Peter Dear and Gillian Maxey, Michael J. Banks, Mike Nicholls, Michael Knipe, Diplomatic Correspondent and Jonathan Braude, Ian Ross, Gordon Robson, David Sapsted, Jamie Dettmer, John Goodbody, Peter Thompson, Philip Webster Chief Political Correspondent, Christopher Walker, Mandarin, George Hill, Srikumar Sen Boxing Correspondent, Matthew Parris, Harvey Elliott and John Young, Paul Newman, Sarah Jane Checkland Art Market Correspondent, R. B. H. Lane, Gerard Noel, Graham Searjeant, David Sinclair, Melinda Wittstock, Stephen Pettitt, Martin Waller, George Chesterton, Michael Horsnell, Alan Coren, Alex Segal (Chairman), Stewart Tendler and Alan Hamilton, John Grant, Derek Harris, David Tytler, Education Editor, Frances Gibb, Chris Moore, Derek Harris Industrial Editor, Raymond Wood, Anne McElvoy, Susan MacDonald, Veronica Heath, David Cross and David Sapsted, Michael Evans, Richard Ford, Political Correspondent, Matthew Bond, Colin Campbell, Susan Ellicott, David Hands, Rugby Correspondent, Andrew Longmore, Tennis Correspondent, Mary Dejevsky, Robert Kilroy-Silk,
... first gold Judges are called to account by Mancini Boxing By a Special Correspondent: Protest at turbos ...
1990 - Gale Group | TDA
Produção Nacional
Revisado por pares
Michael E. Farkouh, Lucas C. Godoy, Maria M. Brooks, G.B. John Mancini, Helen Vlachos, Vera Bittner, Bernard R. Chaitman, Flora S. Siami, Pamela Hartigan, Robert L. Frye, William E. Boden, Valentı́n Fuster,
Elevated low-density lipoprotein cholesterol (LDL-C) is associated with increased cardiovascular events, especially in high-risk populations. This study sought to evaluate the influence of LDL-C on the incidence of cardiovascular events either following a coronary revascularization procedure (percutaneous coronary intervention [PCI] or coronary artery bypass grafting [CABG]) or optimal medical therapy alone in patients with established coronary heart disease and type 2 diabetes (T2DM). Patient-level ...
Tópico(s): Cardiac Imaging and Diagnostics
2020 - Elsevier BV | Journal of the American College of Cardiology
Produção Nacional
Revisado por pares
Renato Mancini Astray, Daniella C. Ventini, Vera Lucia Lopes Boldorini, Fernanda Gonçalves Silva, Mayra Pereira Rocca, Carlos Alberto de Bragança Pereira,
Tópico(s): Viral Infections and Outbreaks Research
2014 - Elsevier BV | Vaccine
Produção Nacional
Revisado por pares
Thaissa Consoni Bernardino, Renato Mancini Astray, Carlos Augusto Pereira, Vera Lucia Lopes Boldorini, Marta Maria Antoniazzi, Simone Gonçalves Silva Jared, Eutímio Gustavo Fernández Núñez, Soraia Attie Calil Jorge,
Tópico(s): Transgenic Plants and Applications
2021 - Springer Science+Business Media | Molecular Biotechnology
Lorenzo Tavelli, Jad Majzoub, Frederic Kauffmann, María Vera Rodríguez, Leonardo Mancini, Hsun‐Liang Chan, Oliver D. Kripfgans, William V. Giannobile, Hom‐Lay Wang, Shayan Barootchi,
To evaluate the efficacy of coronally advanced flap (CAF) versus tunnel technique (TUN) in covering isolated mid-facial peri-implant soft tissue dehiscences (PSTDs).Twenty-eight participants presenting with isolated non-molar implants exhibiting PSTDs were enrolled and randomized to receive either CAF or TUN, both with a connective tissue graft (CTG). The primary outcome of the study was the percentage of mean PSTD coverage at 12 months. Secondary endpoints included the frequency of complete PSTD coverage, ...
Tópico(s): Facial Rejuvenation and Surgery Techniques
2023 - Wiley | Journal Of Clinical Periodontology
Produção Nacional
Revisado por pares
Rob Marchant, Lúcia Massutti de Almeida, Hermann Behling, Juan Carlos Berrío, Mark B. Bush, A.M. Cleef, Joost F. Duivenvoorden, M. Kappelle, Paulo Víctor de Oliveira, Ary Teixeira de Oliveira‐Filho, Socorro Lozano‐García, H. Hooghiemstra, Marie‐Pierre Ledru, Beatríz Ludlow-Wiechers, Vera Markgraf, Virginia Mancini, Marta M. Paez, Aldo R. Prieto, Olando Rangel, Maria Léa Salgado‐Labouriau,
The cornerstone of palaeoecological research, concerned with vegetation dynamics over the recent geological past, is a good understanding of the present-day ecology and distribution of the taxa. This is particularly necessary in areas of high floral diversity such as Latin America. Vegetation reconstructions, based on numerous pollen records, now exist with respect to all major vegetation associations from Latin America. With this ever-increasing number of sedimentary records becoming available, ...
Tópico(s): Plant Diversity and Evolution
2002 - Elsevier BV | Review of Palaeobotany and Palynology
Lorenzo Tavelli, Shayan Barootchi, María Vera Rodríguez, Leonardo Mancini, Jad Majzoub, Sunčica Travan, Jim Sugai, Hsun‐Liang Chan, Oliver D. Kripfgans, Hom‐Lay Wang, William V. Giannobile,
To evaluate the efficacy of recombinant human platelet-derived growth factor (rhPDGF)-BB combined with a cross-linked collagen matrix (CCM) for the treatment of multiple adjacent gingival recession type 1 defects (MAGRs) in combination with the coronally advanced flap (CAF).Thirty patients were enrolled in this triple-blind, randomized, placebo-controlled trial and treated with either CAF + CCM + rhPDGF, or CAF + CCM + saline. The primary outcome was mean root coverage (mRC) at 6 months. Complete root coverage, ...
Tópico(s): Reconstructive Surgery and Microvascular Techniques
2022 - Wiley | Journal Of Clinical Periodontology
Stefano Mancini, Peter M. Keller, Michael Greiner, Vera Bruderer, Frank Imkamp,
A novel New Delhi metallo-β-lactamase (NDM) variant, NDM-19, was identified in a carbapenem-resistant E. coli strain isolated from a subcutaneous infection of a laparotomy scar from an Egyptian patient in a Swiss hospital. NDM-19 is a derivative of NDM-7, from which it differs by a single amino acid substitution (Ala233Val). Under zinc-limiting growth conditions, E. coli DH5α transformants producing NDM-19 displayed reduced susceptibility towards expanded-spectrum cephalosporins and carbapenems as ...
Tópico(s): Pharmaceutical and Antibiotic Environmental Impacts
2019 - Elsevier BV | Diagnostic Microbiology and Infectious Disease
Produção Nacional
Revisado por pares
Lorenzo Tavelli, Shayan Barootchi, María Vera Rodríguez, Leonardo Mancini, Priscila Ceolin Meneghetti, Gustavo Mendonça, Hom‐Lay Wang,
Soft tissue augmentation (STA) at implant sites has the potential of improving peri-implant health, esthetics, and marginal bone level stability. The present study aimed at evaluating the volumetric changes occurring following implant placement in sites that received STA compared to non-augmented sites.A total of 26 subjects received a dental implant in a posterior edentulous site. Simultaneous STA with a xenogeneic cross-linked collagen scaffold was performed for the first 13 patients, while the ...
Tópico(s): Bone Tissue Engineering Materials
2021 - Wiley | Journal of Esthetic and Restorative Dentistry
Lucy Withington, David Díaz Pardo de Vera, Claire Guest, Clara Mancini, Paul Piwek,
The aim of this research was to discover if artificial neural networks can be used to classify pressure sensor data generated by medical detection dogs as they sniff biological samples. A detection dog can be trained to recognise the odour emitted by one of a wide range of diseases such as prostate cancer, malaria or, potentially, COVID-19. The dog searches a row of sample pots and indicates a positive sample by sitting in front of it. This offers a non-invasive means of diagnosing the specific ...
Tópico(s): Food Supply Chain Traceability
2021 - Elsevier BV | Expert Systems with Applications
Lorenzo Tavelli, Oliver D. Kripfgans, Hsun‐Liang Chan, María Vera Rodríguez, Hamoun Sabri, Leonardo Mancini, Hom‐Lay Wang, William V. Giannobile, Shayan Barootchi,
Abstract Aim To assess the Doppler ultrasonographic tissue perfusion at dental implant sites augmented with connective tissue graft (CTG) using coronally advanced flap (CAF) or tunnel technique (TUN). Materials and Methods Twenty‐eight patients presenting with isolated healthy peri‐implant soft‐tissue dehiscence (PSTD) were included in this randomized clinical trial. PSTDs were treated with either CAF + CTG or TUN + CTG. Ultrasound scans were taken at baseline, 1 week, 1 month, 6 months and 12 months. Tissue ...
Tópico(s): Electrospun Nanofibers in Biomedical Applications
2023 - Wiley | Journal Of Clinical Periodontology
Michael E. Farkouh, Mandeep S. Sidhu, Maria M. Brooks, Helen Vlachos, William E. Boden, Robert L. Frye, Pamela Hartigan, Flora S. Siami, Vera Bittner, Bernard R. Chaitman, G.B. John Mancini, Valentı́n Fuster,
The optimal coronary revascularization strategy in patients with stable ischemic heart disease (SIHD) who have type 2 diabetes (T2DM) and chronic kidney disease (CKD) remains unclear. This patient-level pooled analysis sought to compare outcomes of 3 large, federally-funded randomized trials in SIHD patients with T2DM and CKD (COURAGE [Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation], BARI 2D [Bypass Angioplasty Revascularization Investigation 2 Diabetes], and FREEDOM [Future ...
Tópico(s): Cardiovascular Function and Risk Factors
2019 - Elsevier BV | Journal of the American College of Cardiology
G.B. John Mancini, William E. Boden, Maria M. Brooks, Helen Vlachos, Bernard R. Chaitman, Robert L. Frye, Vera Bittner, Pamela Hartigan, Gilles R. Dagenais,
The impact of treatment strategies on outcomes in patients with stable coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM) according to presenting angina has not been rigorously assessed.We performed a patient-level pooled-analysis (n = 5027) of patients with stable CAD and T2DM randomized to optimal medical therapy [OMT], percutaneous coronary intervention [PCI] + OMT, or coronary artery bypass grafting [CABG] + OMT. Endpoints were death/myocardial infarction (MI)/stroke, post-randomization revascularization ( ...
Tópico(s): Antiplatelet Therapy and Cardiovascular Diseases
2018 - Elsevier BV | Atherosclerosis
Produção Nacional
Revisado por pares
Eutímio Gustavo Fernández Núñez, Jaci Leme, Letícia de Almeida Parizotto, Wagner Antonio Chagas, Alexandre Gonçalves de Rezende, Bruno Labate Vale da Costa, Daniela Cristina Ventini Monteiro, Vera Lucia Lopes Boldorini, Soraia Attie Calil Jorge, Renato Mancini Astray, Carlos Augusto Pereira, Celso Pereira Caricati, Aldo Tonso,
This work focused on determining the effect of dissolved oxygen concentration (DO) on growth and metabolism of BHK-21 cell line (host cell for recombinant proteins manufacturing and viral vaccines) cultured in two stirred tank bioreactors with different aeration-homogenization systems, as well as pH control mode. BHK-21 cell line adapted to single-cell suspension was cultured in Celligen without aeration cage (rotating gas-sparger) and Bioflo 110, at 10, 30 and 50 % air saturation (impeller for gas dispersion ...
Tópico(s): thermodynamics and calorimetric analyses
2013 - Springer Science+Business Media | Cytotechnology
Produção Nacional
Revisado por pares
Jaci Leme, Eutímio Gustavo Fernández Núñez, Letícia de Almeida Parizotto, Wagner Antonio Chagas, Erica Salla dos Santos, Aline Tojeira Prestia Caricati, Alexandre Gonçalves de Rezende, Bruno Labate Vale da Costa, Daniela Cristina Ventini Monteiro, Vera Lucia Lopes Boldorini, Soraia Attie Calil Jorge, Renato Mancini Astray, Carlos Augusto Pereira, Celso Pereira Caricati, Aldo Tonso,
Monitoring mammalian cell culture with UV–vis spectroscopy has not been widely explored. The aim of this work was to calibrate Partial Least Squares (PLS) models from off-line UV–vis spectral data in order to predict some nutrients and metabolites, as well as viable cell concentrations for mammalian cell bioprocess using phenol red in culture medium. The BHK-21 cell line was used as a mammalian cell model. Spectra of samples taken from batches performed at different dissolved oxygen concentrations ( ...
Tópico(s): thermodynamics and calorimetric analyses
2013 - American Chemical Society | Biotechnology Progress
Alexios Batrakoulis, Óscar L. Veiga, Susana Franco, Ewan Thomas, Antonios Alexopoulos, Manel Valcarce Torrente, Rita Santos‐Rocha, Fátima Ramalho, Andrea Di Credico, Daniela Vitucci, Liliana Ramos, Vera Simões, Alejandro Romero-Caballero, Isabel Vieira, Annamaria Mancini, Antonino Bianco,
<abstract> <p>The physical activity, exercise and wellness sector is rapidly growing and seems to be an exciting field for business and professional development with great potential globally. The purpose of this observational and cross-sectional study was to determine the most popular health and fitness trends in Southern Europe for the first time, including data from Italy, Spain, Portugal, Greece and Cyprus, and to investigate any potential differences in this area compared to the Pan- ...
Tópico(s): Body Composition Measurement Techniques
2023 - AIMS Press | AIMS Public Health
Produção Nacional
Revisado por pares
Micaela Mancini, Hugo R. Permingeat, Carolina Colono, Lorena Siena, Fulvio Pupilli, Celeste Azzaro, Diva Maria de Alencar Dusi, Vera Tavares de Campos Carneiro, Maricel Podio, Guillermo Seijo, Ana María González, Silvina A. Felitti, Juan Pablo A. Ortiz, Olivier Leblanc, Silvina C. Pessino,
Apomixis is a clonal mode of reproduction via seeds, which results from the failure of meiosis and fertilization in the sexual female reproductive pathway. In previous transcriptomic surveys, we identified a mitogen-activated protein kinase kinase kinase (N46) displaying differential representation in florets of sexual and apomictic Paspalum notatum genotypes. Here we retrieved and characterized the N46 full cDNA sequence from sexual and apomictic floral transcriptomes. Phylogenetic analyses showed ...
Tópico(s): Seedling growth and survival studies
2018 - Frontiers Media | Frontiers in Plant Science
Julian Koenig, Birgit Abler, Ingrid Agartz, Torbjörn Åkerstedt, Ole A. Andreassen, Mia Anthony, Karl‐Jürgen Bär, Katja Bertsch, Rebecca C. Brown, Romuald Brunner, Luca Carnevali, Hugo Critchley, Kathryn R. Cullen, Eco J. C. de Geus, Feliberto de la Cruz, Isabel Dziobek, Marc D. Ferger, Håkan Fischer, Herta Flor, Michael Gaebler, Peter J. Gianaros, Melita J. Giummarra, Steven G. Greening, Simón Guendelman, James Heathers, Sabine C. Herpertz, Mandy X. Hu, Sebastian Jentschke, Michael Kaess, Tobias Kaufmann, Bonnie Klimes‐Dougan, Stefan Koelsch, Marlene Krauch, Deniz Kumral, Femke Lamers, Tae‐Ho Lee, Mats Lekander, Feng Lin, Martín Lotze, Elena Makovac, Matteo Mancini, Falk Mancke, Kristoffer Månsson, Stephen B. Manuck, Mara Mather, Frances Meeten, Jungwon Min, Bryon A. Mueller, Vera Muench, Frauke Nees, Lin Nga, Gustav Nilsonne, Daniela Ordonez Acuna, Berge Osnes, Cristina Ottaviani, Brenda W.J.H. Penninx, Allison Ponzio, Govinda Poudel, Janis Reinelt, Ping Ren, Michiko Sakaki, Andy Schumann, Lin Sørensen, Karsten Specht, Joana Straub, Sandra Tamm, Michelle Thai, Julian F. Thayer, Benjamin Ubani, Denise J. van der Mee, Laura S. van Velzen, Carlos Ventura‐Bort, Arno Villringer, David R. Watson, Luqing Wei, Julia Wendt, Melinda Westlund Schreiner, Lars T. Westlye, Mathias Weymar, Tobias Winkelmann, Guo‐Rong Wu, Hyun Joo Yoo, Daniel Quintana,
Understanding the association between autonomic nervous system [ANS] function and brain morphology across the lifespan provides important insights into neurovisceral mechanisms underlying health and disease. Resting-state ANS activity, indexed by measures of heart rate [HR] and its variability [HRV] has been associated with brain morphology, particularly cortical thickness [CT]. While findings have been mixed regarding the anatomical distribution and direction of the associations, these inconsistencies ...
Tópico(s): Cardiovascular Health and Disease Prevention
2020 - Wiley | Psychophysiology
G.B. John Mancini, Michael E. Farkouh, Maria M. Brooks, Bernard R. Chaitman, William E. Boden, Helen Vlachos, Pamela Hartigan, Flora S. Siami, Mandeep S. Sidhu, Vera Bittner, Robert L. Frye, Valentı́n Fuster,
There are scant outcomes data in patients with type 2 diabetes and stable coronary artery disease (CAD) stratified by detailed angiographic burden of CAD or left ventricular ejection fraction (LVEF). This study determined the effect of optimal medical therapy (OMT), with or without percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG), on long-term outcomes with respect to LVEF and number of diseased vessels, including proximal left anterior descending artery involvement. ...
Tópico(s): Cerebrovascular and Carotid Artery Diseases
2016 - Elsevier BV | Journal of the American College of Cardiology
Produção Nacional
Revisado por pares
Lydiane Hirschler, Nico Sollmann, Bárbara Schmitz‐Abecassis, Joana Pinto, Fatemehsadat Arzanforoosh, Frederik Barkhof, Thomas C. Booth, Marta Calvo‐Imirizaldu, Guilherme de Souza e Cassia, Marek Chmelík, Patricia Clement, Ece Ercan, María A. Fernández‐Seara, Julia Furtner, Elies Fuster‐García, Matthew Grech‐Sollars, Nazmiye Tugay Guven, Gökçe Hale Hatay, Golestan Karami, Vera C. Keil, Mina Kim, Johan A F Koekkoek, Simran Kukran, Laura Mancini, Ruben Emanuel Nechifor, Alpay Özcan, Esin Öztürk-Işık, Şenol Pişkin, Kathleen M. Schmainda, Siri Fløgstad Svensson, Chih‐Hsien Tseng, Saritha Unnikrishnan, Frans M. Vos, Esther A. H. Warnert, Moss Zhao, Radim Jančálek, Teresa Nunes, Kyrre E. Emblem, Marion Smits, Jan Petr, Gilbert Hangel,
Preoperative clinical magnetic resonance imaging (MRI) protocols for gliomas, brain tumors with dismal outcomes due to their infiltrative properties, still rely on conventional structural MRI, which does not deliver information on tumor genotype and is limited in the delineation of diffuse gliomas. The GliMR COST action wants to raise awareness about the state of the art of advanced MRI techniques in gliomas and their possible clinical translation or lack thereof. This review describes current methods, ...
Tópico(s): Glioma Diagnosis and Treatment
2023 - Wiley | Journal of Magnetic Resonance Imaging
Produção Nacional
Revisado por pares
Gilbert Hangel, Bárbara Schmitz‐Abecassis, Nico Sollmann, Joana Pinto, Fatemehsadat Arzanforoosh, Frederik Barkhof, Thomas C. Booth, Marta Calvo‐Imirizaldu, Guilherme de Souza e Cassia, Marek Chmelík, Patricia Clement, Ece Ercan, María A. Fernández‐Seara, Julia Furtner, Elies Fuster‐García, Matthew Grech‐Sollars, Nazmiye Tugay Guven, Gökçe Hale Hatay, Golestan Karami, Vera C. Keil, Mina Kim, Johan A F Koekkoek, Simran Kukran, Laura Mancini, Ruben Emanuel Nechifor, Alpay Özcan, Esin Öztürk-Işık, Şenol Pişkin, Kathleen M. Schmainda, Siri Fløgstad Svensson, Chih‐Hsien Tseng, Saritha Unnikrishnan, Frans M. Vos, Esther A. H. Warnert, Moss Zhao, Radim Jančálek, Teresa Nunes, Lydiane Hirschler, Marion Smits, Jan Petr, Kyrre E. Emblem,
Preoperative clinical MRI protocols for gliomas, brain tumors with dismal outcomes due to their infiltrative properties, still rely on conventional structural MRI, which does not deliver information on tumor genotype and is limited in the delineation of diffuse gliomas. The GliMR COST action wants to raise awareness about the state of the art of advanced MRI techniques in gliomas and their possible clinical translation. This review describes current methods, limits, and applications of advanced ...
Tópico(s): Advanced MRI Techniques and Applications
2023 - Wiley | Journal of Magnetic Resonance Imaging
Produção Nacional
Revisado por pares
Renato Mancini Astray, Soraia Attie Calil Jorge, Marcos Alexandre Nobre Lemos, Adriana Y. Yokomizo, Vera Lucia Lopes Boldorini, Ana L.P. Puglia, Orlando Ribeiro, Carlos Alberto de Bragança Pereira,
Recombinant rabies virus glycoprotein (RVGP) was expressed in cell membranes of stably transfected Drosophila S2 cells using constitutive and inducible promoters. Although with quantitative differences of RVGP expression in both systems, the cDNA transcription, as evaluated by relative RVGP mRNA levels measured by qRT-PCR, sustained the amount of RVGP producing cells and the RVGP volumetric (ΠRVGP) productivity. At the transition to the stationary cell growth phase, once the cell culture slowed down ...
Tópico(s): Toxin Mechanisms and Immunotoxins
2013 - Springer Science+Business Media | Cytotechnology
Elizabeth Phillips, Bridget A. Bergquist, Michelle M. G. Chartrand, Weibin Chen, Elizabeth A. Edwards, Martin Elsner, Tetyana Gilevska, Sarah Hirschorn, Axel Horst, Georges Lacrampe‐Couloume, Silvia Mancini, Jennifer McKelvie, Penny L. Morrill, Ann Ojeda, Gregory F. Slater, Brent E. Sleep, Joan De Vera, Oliver Warr, Elodie Passeport,
Here, we review the contributions of Professor Barbara Sherwood Lollar to Compound Specific Isotope Analysis (CSIA) in contaminant hydrogeology and environmental chemistry. We first discuss the seminal work by Professor Sherwood Lollar's lab on establishing CSIA as a quantitative tool for contaminant (bio)transformation at contaminated groundwater sites. We describe the critical research by her lab in the development and validation of sample collection techniques, single- and multi-element CSIA, and ...
Tópico(s): Microbial Community Ecology and Physiology
2022 - Elsevier BV | Journal of Hydrology
Domenico Russo, Nicola Polverelli, Simona Bernardi, Stella Santarone, Mirko Farina, Erika Borlenghi, Francesco Onida, Luca Castagna, Stéfania Bramanti, Angelo Michele Carella, Roberto Sorasio, Massimo Martino, Caterina Alati, Attilio Olivieri, Germana Beltrami, Antonio Curti, Calogero Vetro, Salvatore Leotta, Valentina Mancini, Elisabetta Terruzzi, Massimo Bernardi, Piero Galieni, Pellegrino Musto, Raffaella Cerretti, Luisa Giaccone, Cristina Skert, Vera Radici, Marika Vezzoli, Stefano Calza, Alessandro Leoni, Luca Garuffo, Cristian Bonvicini, Simone Pellizzeri, Michele Malagola, Fabio Ciceri,
Access to allogeneic haematopoietic stem-cell transplantation (HSCT) remains challenging for older patients (aged >60 years) with acute myeloid leukaemia. We aimed to evaluate the efficacy of venetoclax plus decitabine as first-line therapy and bridge to transplantation in this patient population.
Tópico(s): Acute Lymphoblastic Leukemia research
2024 - Elsevier BV | The Lancet Haematology
Produção Nacional
Revisado por pares
Alain Verloès, Nataliya Di Donato, Julien Masliah‐Planchon, Marjolijn C.J. Jongmans, Omar A Abdul-Raman, Beate Albrecht, Judith Allanson, Han G. Brunner, Débora Romeo Bertola, Nicolas Chassaing, Albert David, Koenraad Devriendt, Pirayeh Eftekhari, Valérie Drouin‐Garraud, Francesca Faravelli, Laurence Faivre, Fabienne Giuliano, Leina Guion Almeida, Jorge L. Juncos, Marlies Kempers, Hatice Koçak Eker, Didier Lacombe, Angela E. Lin, Grazia M.S. Mancini, Daniela Melis, Charles Marques Lourenço, Victoria Mok Siu, G Morin, Marjan M. Nezarati, Małgorzata J.M. Nowaczyk, Jeanette C. Ramer, Sara Osimani, Nicole Philip, Mary Ella Pierpont, Vincent Procaccio, Zeichi-Seide Roseli, Massimiliano Rossi, Cristina Rusu, Yves Sznajer, Ludivine Templin, Vera Uliana, Mirjam Klaus, Bregje W.M. van Bon, Conny van Ravenswaaij, Bruce H. Wainer, Andrew E. Fry, Andreas Rump, Alexander Hoischen, Séverine Drunat, Jean‐Baptiste Rivière, William B. Dobyns, Daniela T. Pilz,
Baraitser–Winter, Fryns–Aftimos and cerebrofrontofacial syndrome types 1 and 3 have recently been associated with heterozygous gain-of-function mutations in one of the two ubiquitous cytoplasmic actin-encoding genes ACTB and ACTG1 that encode β- and γ-actins. We present detailed phenotypic descriptions and neuroimaging on 36 patients analyzed by our group and six cases from the literature with a molecularly proven actinopathy (9 ACTG1 and 33 ACTB). The major clinical anomalies are striking dysmorphic ...
Tópico(s): Amino Acid Enzymes and Metabolism
2014 - Springer Nature | European Journal of Human Genetics
Pleuntje J. van der Sluijs, Sandra Jansen, Samantha A. Schrier Vergano, Miho Adachi-Fukuda, Yasemin Alanay, Adila Al‐Kindy, Anwar Baban, Allan Bayat, Stefanie Beck‐Wödl, Katherine Berry, Emilia K. Bijlsma, Levinus A. Bok, Alwin F.J. Brouwer, Ineke van der Burgt, Philippe M. Campeau, Natalie Canham, Krystyńa Chrzańowska, Yoyo W. Y. Chu, Brain H.Y. Chung, Karin Dahan, Marjan De Rademaeker, Anne Destrėe, Tracy Dudding‐Byth, Rachel K. Earl, Nursel Elçioğlu, Ellen Roy Elias, Christina Fagerberg, Alice Gardham, Blanca Gener, Erica H. Gerkes, Ute Grasshoff, Arie van Haeringen, Karin R. Heitink, Johanna C. Herkert, Nicolette S. den Hollander, Denise Horn, David Hunt, Sarina G. Kant, Mitsuhiro Kato, Hülya Kayserili, Rogier Kersseboom, Esra KAYA KILIÇ, Małgorzata Krajewska‐Walasek, Kylin Lammers, Lone Walentin Laulund, Damien Lederer, Melissa Lees, Vanesa López‐González, Saskia M. Maas, Grazia M.S. Mancini, Carlo Marcelis, Francisco Martı́nez, Isabelle Maystadt, Marianne McGuire, Shane McKee, Sarju Mehta, Kay Metcalfe, Jeff M. Milunsky, Seiji Mizuno, John B. Moeschler, Christian Netzer, Charlotte W. Ockeloen, Barbara Oehl‐Jaschkowitz, Nobuhiko Okamoto, Sharon N.M. Olminkhof, Carmen Orellana, Laurent Pasquier, Caroline Pottinger, Vera Riehmer, Stephen P. Robertson, Maian Roifman, Caroline Rooryck, Fabienne G. Ropers, Mónica Roselló, Claudia Ruivenkamp, Mahmut Şamil Sağıroğlu, Suzanne C.E.H. Sallevelt, A. Sanchís Calvo, Pelin Özlem Şimşek‐Kiper, Gabriela Soares, Lucia Solaeche, Fatma Müjgan Sönmez, Miranda Splitt, Duco Steenbeek, Alexander P.A. Stegmann, Constance T. R. M. Stumpel, Saori Tanabe, Eyyüp Üçtepe, Gülen Eda Ütine, Hermine E. Veenstra‐Knol, Sunita Venkateswaran, Catheline Vilain, Catherine Vincent‐Delorme, Anneke T. Vulto‐van Silfhout, Patricia G. Wheeler, Golder N. Wilson, Louise C. Wilson, Bernd Wollnik, Tomoki Kosho, Dagmar Wieczorek, Evan E. Eichler, Rolph Pfundt, Bert B.A. de Vries, Jill Clayton‐Smith, Gijs W.E. Santen,
ABSTRACT Purpose Pathogenic variants in ARID1B are one of the most frequent causes of intellectual disability (ID) as determined by large-scale exome sequencing studies. Most studies published thus far describe clinically diagnosed Coffin–Siris patients (ARID1B-CSS) and it is unclear whether these data are representative for patients identified through sequencing of unbiased ID cohorts (ARID1B-ID). We therefore sought to determine genotypic and phenotypic differences between ARID1B-ID and ARID1B-CSS. In parallel, ...
Tópico(s): Peptidase Inhibition and Analysis
2018 - Elsevier BV | Genetics in Medicine
Produção Nacional
Revisado por pares
Eutímio Gustavo Fernández Núñez, Jaci Leme, Letícia de Almeida Parizotto, Alexandre Gonçalves de Rezende, Bruno Labate Vale da Costa, Vera Lucia Lopes Boldorini, Soraia Attie Calil Jorge, Renato Mancini Astray, Carlos Augusto Pereira, Celso Pereira Caricati, Aldo Tonso,
Mammalian cells are the most frequently used hosts for biopharmaceutical proteins manufacturing. Inoculum quality is a key element for establishing an efficient bioconversion process. The main objective in inoculation expansion process is to generate large volume of viable cells in the shortest time. The aim of this paper was to optimize the inoculum preparation stage of baby hamster kidney (BHK)-21 cells for suspension cultures in benchtop bioreactors, by means of a combination of static and agitated ...
Tópico(s): Transgenic Plants and Applications
2014 - Springer Science+Business Media | Cytotechnology
Produção Nacional
Revisado por pares
Natasza Kosakowska‐Berezecka, Tomasz Besta, Jennifer K. Bosson, Paweł Jurek, Joesph A. Vandello, Deborah L. Best, Anna Włodarczyk, Saba Safdar, Magdalena Zawisza, Magdalena Żadkowska, Jurand Sobiecki, Collins Badu Agyemang, Gülçin Akbaş, Soline Ammirati, Joel Anderson, Gulnaz Anjum, John Jamir Benzon R. Aruta, Mujeeba Ashraf, Aistė Bakaitytė, Chongzeng Bi, Maja Becker, Michael Bender, Dashamir Bërxulli, Janine Bosak, Serena Daalmans, Justine Dandy, Soledad de Lemus, Н В Дворянчиков, Edgardo Etchezahar, Laura Froehlich, Alin Gavreliuc, Dana Gavreliuc, Ángel Gómez, Hedy Greijdanus, A. K. Grigoryan, Miriam‐Linnea Hale, Hannah Hämer, Vera Hoorens, Paul B. Hutchings, Dorthe Høj Jensen, Kaltrina Kelmendi, Narine Khachatryan, Mary Kinahan, Desirée Kozlowski, Mary Anne Lauri, Junyi Li, Angela T. Maitner, Ana Makashvili, Tiziana Mancini, Sarah E. Martiny, Jasna Milošević Đorđević, Eva Moreno‐Bella, Silvia Moscatelli, Andrew B. Moynihan, Dominique Müller, Danielle P. Ochoa, Sulaiman Olanrewaju Adebayo, Maria Giuseppina Pacilli, Jorge Palacio, Snigdha Patnaik, Vassilis Pavlopoulos, Ivana Piterová, Angelica Puzio, Joanna Pyrkosz‐Pacyna, Érico Rentería Pérez, Tiphaine Rousseaux, Mario Sainz, Marco Salvati, Adil Samekin, Efraín García‐Sánchez, Simon Schindler, Sara Sherbaji, Rosita Sobhie, Dijana Sulejmanović, Katie Sullivan, Beatriz A. Torre, Cláudio Torres, Joaquín Ungaretti, Timothy Jacob Valshtein, Colette van Laar, Jolanda van der Noll, Vadym Vasiutynskyi, Neharika Vohra, Antonella Ludmila Zapata‐Calvente, Rita Žukauskienė,
Abstract Men sometimes withdraw support for gender equality movements when their higher gender status is threatened. Here, we expand the focus of this phenomenon by examining it cross‐culturally, to test if both individual‐ and country‐level variables predict men's collective action intentions to support gender equality. We tested a model in which men's zero‐sum beliefs about gender predict reduced collective action intentions via an increase in hostile sexism. Because country‐level gender equality ...
Tópico(s): Gender Diversity and Inequality
2020 - Wiley | European Journal of Social Psychology