... der Tachycarden Arrhythmien und der Arteriellen Hyiertonie mit Verapamil. Arzneimittel-Forsch, 1970, 20, 1310. PubMedWeb of Science® ... Persson & S. E. Svensson: Double-blind Comparison of Verapamil and Practolol in the Treatment of Angina Pectoris. ... M.: Hemmung der drohenden Frühgeburt mit Nylidrin und Verapamil. Z. Geburtsh. Perinat. 1975, 179, 261. CASPubMedGoogle Scholar ... Prevention of Hereditary Cardiomyopathy in the Hamster by Verapamil and Other Agents. Proc. Soc. Exp. Biol. Med. ... p. 268, Amsterdam 1976. Google Scholar Krikler, D.: Verapamil in Cardiology, Europ. J. Cardiol. 1974, 2, 3. ...
Tópico(s): Heart Failure Treatment and Management
1978 - Wiley | Acta Pharmacologica et Toxicologica
Ichiro Yamaguchi, Kanji Obayashi, William J. Mandel,
Previous studies have demonstrated that verapamil possess potent anti-arrhythmic effects. The present study has been designed to define the cardiovascular effects of this drug. Isolated tissue ... change maximum diastolic potential. At this dose of verapamil, sinoatrial conduction time prolonged significantly (control: 40.0± 4.8 ms; 1 × 10−7mollitre−1 verapamil: 50.0± 6.4 ms). Purkinje fibre studies ... exposure to >1 × 10−5 mol·litre−1 verapamil. Electrophysiological studies in conscious dogs demonstrated, after bolus ...
Tópico(s): Cardiac pacing and defibrillation studies
1978 - Oxford University Press | Cardiovascular Research
Joseph Shanfeld, Marilyn E. Hess, N R Levine,
The effects of verapamil on myocardial isometric force on contraction, cardiac adenosine 3,'5'-monophosphate (cyclic AMP) and heart phosphorylase alpha activity were ... perfused rat heart. When hearts were perfused with verapamil (5.98 times 10- minus 8 M), force ... In hearts perfused continuously for 60 minutes with verapamil, force of contraction and cyclic AMP levels returned to normal within 20 minutes after administration of verapamil was begun. Isoproterenol (0.355 nmol/min) reversed the depressant effect of verapamil on cardiac contractility and restored heart cyclic AMP ...
Tópico(s): Cardiac Ischemia and Reperfusion
1975 - American Society for Pharmacology and Experimental Therapeutics | Journal of Pharmacology and Experimental Therapeutics
Koki Shigenobu, Joel A. Schneider, N. Sperelakis,
Verapamil was used to characterize further the slow cation responses found in myocardial cells either normally or ... Na + current must be the main inward current. Verapamil (2 µg/ml) rapidly blocked all excitability and ... V max ) to about 10 V/sec, and verapamil, but not 1 mM Mn ++ , blocked the electrical ... tetrodotoxin. Since Mn ++ should block any Ca ++ influx, verapamil must block slow Na + responses. 3) In 15-day hearts, verapamil partially depressed the action potential plateau (without affecting + V max ) concomitant with electromechanical uncoupling. Verapamil also slowly produced a small depolarization, particularly in ...
Tópico(s): Neuroscience and Neuropharmacology Research
1974 - American Society for Pharmacology and Experimental Therapeutics | Journal of Pharmacology and Experimental Therapeutics
Michael R. Rosen, Joseph P. Ilvento, Henry Gelband, Charles Merker,
... techniques were used to determine the effects of verapamil, 2 x 10 -7 to 1 x 10 - ... electrophysiologic properties of isolated canine cardiac Purkinje fibers. Verapamil, -6 M, had no effect on the Purkinje fiber action potential (AP). Verapamil, 2 x 10 -6 M, altered repolarization primarily ... 1 and increasing the slope of phase 2. Verapamil, ≥6 x 10 -6 M, had more pronounced ... duration to effective refractory period was unchanged by verapamil. Conduction velocity was slowed only by verapamil, ≥6 x 10 -6 M. The effects of ...
Tópico(s): Cardiac Arrhythmias and Treatments
1974 - American Society for Pharmacology and Experimental Therapeutics | Journal of Pharmacology and Experimental Therapeutics
Keisuke Satoh, Teruyuki Yanagisawa, Norio Taira,
Summary Coronary vasodilator and cardiac effects of (-) and (+) verapamil were investigated in two kinds of canine heart ... When administered intravenously to anesthetized open-chest dogs, (-) verapamil was only 1.5–2 times as potent as (+) verapamil in increasing coronary sinus outflow and in decreasing mean arterial pressure and coronary resistance. However, (-) verapamil was about 5 times as potent in producing ... as potent in decreasing myocardial oxygen consumption as (+) verapamil. When injected into the anterior septal artery in ...
Tópico(s): Cardiac Ischemia and Reperfusion
1980 - Lippincott Williams & Wilkins | Journal of Cardiovascular Pharmacology
... metabolic cost of administering an experimental calcium antagonist, verapamil, to patients with coronary artery disease, 12 such ... atrial pacing before and after intravenous treatment with verapamil (bolus dose of 0.1 mg/kg body ... min (p < 0.01), respectively, after administration of verapamil. With atrial pacing, these values were 105 +/- 25 ... 4 ml O2/min, respectively, before infusion of verapamil, and then decreased to 87 +/- 14 mm Hg ( ... occurred in all patients with atrial pacing before verapamil (threshold to pain: 93 +/- 67 seconds). After verapamil, ...
Tópico(s): Muscle activation and electromyography studies
1980 - Elsevier BV | The American Journal of Cardiology
Douglas R. Rosing, Kenneth M. Kent, Barry J. Moron, John R. Condit, Stephen E. Epstein,
The hemodynamic and clinical effects of verapamil administration were examined in patients with hypertrophic cardiomyopathy. Infusion of 0.021 mg/kg/min of verapamil decreased the basal left ventricular outflow tract gradient ... patients considered their symptomatic status "best" while receiving verapamil, seven while receiving placebo, and only three while ... have been discharged from the hospital receiving longterm verapamil therapy, and 49 have reported continuing symptomatic benefit ... exercise capacity up to two years later. Thus, verapamil can improve exercise capacity and symptomatic status in ...
Tópico(s): Advanced battery technologies research
1980 - Elsevier BV | CHEST Journal
The effect of verapamil on Ca2+ and Mg2+ accumulation was investigated in isolated rat kidney cortex mitochondria. For the 50% inhibition of Ca2+ accumulation, 2 x 10(-4) M verapamil concentration was required in the presence of ATP ( ... from the medium increased the inhibitory effect of verapamil on Ca2+ accumulation. Verapamil had no effect on Ca2+ accumulation in the ... in a significant inhibition of Ca2+ accumulation by verapamil. Mg2+ accumulation of mitochondria was similarly depressed by verapamil. The same tendency was found as for the ...
Tópico(s): Drug Transport and Resistance Mechanisms
1979 - Japanese Pharmacological Society | The Japanese Journal of Pharmacology
Douglas R. Rosing, K.M. Kent, B J Maron, Stephen E. Epstein,
... non-Asian patient: Favorable response to treatment with verapamil, American Heart Journal, 10.1016/0002-8703(94) ... Salvadori P and Camici P (1994) Effect of verapamil on absolute myocardial blood flow in hypertrophic cardiomyopathy, ... on left ventricular function of pindolol added to verapamil in hypertrophic cardiomyopathy, The American Journal of Cardiology, ... blind, placebo-controlled crossover trial of nadolol and verapamil in mild and moderately symptomatic hypertrophic cardiomyopathy, Journal ... of the Calcium Channel-Blocking Agents Diltiazem and Verapamil for Treatment of Feline Hypertrophic Cardiomyopathy, Journal of ...
Tópico(s): Innovation Policy and R&D
1979 - Lippincott Williams & Wilkins | Circulation
T. Lin, Eisuke P. Murono, J. Osterman, Philip Troen, Howard R. Nankin,
The effect of verapamil on interstitial cell steroidogenesis was studied. Collagenase‐dispersed interstitial cells were incubated with varying amounts of LH, 8‐bromo‐cyclic AMP, or verapamil. Cyclic AMP and testosterone were determined in media after 4‐hour incubations. Verapamil in the doses of 10 ‐4 and 10 ‐ ... LH‐induced testosterone biosynthesis, while 10 ‐6 M verapamil had no effect. The inhibition persisted even though LH was increased 100 fold. Verapamil (10 ‐5 M) also significantly reduced 8‐bromo‐ ...
Tópico(s): Sperm and Testicular Function
1979 - Wiley | Andrology
... matrix and have an important role in inflammation. Verapamil is a calcium channel blocker extensively used in ... The anti-tumor and anti-inflammatory effects of verapamil have also been shown. In this study, the effect of verapamil on gelatinase activity in human peripheral blood mononuclear ... and after that incubated with different concentrations of verapamil (0-200 μM) in the presence or absence ... groups were made by analysis of variance (ANOVA).Verapamil significantly decreased the MMP-2/MMP-9 activity ...
Tópico(s): Peptidase Inhibition and Analysis
1979 - Cell Press | Cell
... myectomy.Several studies, however, have shown that administering verapamil, the prototype calcium-channel blocking agent, to patients ... 1964;29:84-98. CrossrefMedlineGoogle Scholar4. ROSINGKENTBORERSEIDESMARONEPSTEIN DKJSBS. Verapamil therapy: a new approach to the pharmacologic treatment ... KALTENBACHHOPFKOBERBUSSMANKELLERPETERSEN MRGWMY. Treatment of hypertrophic obstructive cardiomyopathy with verapamil. Br Heart J. 1979;42:35-42. CrossrefMedlineGoogle Scholar6. ROSINGKENTMARONEPSTEIN DKBS. Verapamil therapy: a new approach to the pharmacologic treatment ...
Tópico(s): Cardiac Imaging and Diagnostics
1982 - American College of Physicians | Annals of Internal Medicine
Vance J. Plumb, Robert B. Karp, Nicholas T. Kouchoukos, George L. Zorn, Thomas N. James, Albert L. Waldo,
... assessed the efficacy and safety of using intravenous verapamil to treat these arrhythmias. Following cardiac operation, 28 ... fibrillation or atrial flutter received either low-dose verapamil (0.075 mg/kg) or placebo, using a randomized double-blind crossover protocol. When low-dose verapamil was given to 21 patients with atrial fibrillation, ... fibrillation, in whom the response to low-dose verapamil was either brief or incomplete, later received standard-dose verapamil (0.15 mg/kg), following which the ventricular ...
Tópico(s): Cardiac Arrhythmias and Treatments
1982 - Elsevier BV | Journal of Thoracic and Cardiovascular Surgery
Robert O. Bonow, M.B. Leon, Douglas R. Rosing, K.M. Kent, Lewis C. Lipson, Stephen L. Bacharach, Maurice Green, Stephen E. Epstein,
To determine the effects of verapamil on left ventricular (LV) systolic function and diastolic filling in patients with coronary artery disease (CAD), we performed gated radionuclide angiography ... in 16 symptomatic patients before and during oral verapamil therapy (480 mg/day). Twelve patients were also ... than 180 msec, was present in 15. During verapamil, resting ejection fraction decreased (control 50 +/- 10% [+/- SD), verapamil 45 +/- 12%, p less than 0.005), but ... increased (control 1.9 +/- 0.6 EDV/sec, verapamil 2.3 +/- 0.9 ECV/sec, p less ...
Tópico(s): Atrial Fibrillation Management and Outcomes
1982 - Lippincott Williams & Wilkins | Circulation
Ronald W. Millard, David A. Lathrop, Günter Grupp, Muhammad Ashraf, Ingrid L. Grupp, Arnold Schwartz,
... major calcium channel blocking agents, diltiazem, nifedipine and verapamil, inhibit calcium entry into excitable cells. Despite this ... flow in a dose-dependent fashion (nifedipine > diltiazem = verapamil), and produce a negative inotropic effect in vitro ... and ventricles, also in a dose-dependent manner (verapamil > nifedipine > diltiazem). However, in conscious dogs nifedipine increases, verapamil decreases and diltiazem has little effect on the ... A-V conduction is slowed by diltiazem and verapamil but not by nifedipine in anesthetized dogs and ...
Tópico(s): Pharmacological Receptor Mechanisms and Effects
1982 - Elsevier BV | The American Journal of Cardiology
Michael D. Winniford, Roy V. Markham, Brian G. Firth, Pascal Nicod, L.David Hillis,
... we assessed the hemodynamic and electrophysiologic effects of verapamil or nifedipine in patients receiving oral propranolol. In ... saline solution, 10 ml (n = 6); (2) intravenous verapamil, 0.15 mg/kg body weight to a ... by thermodilution) was unchanged after saline solution and verapamil but increased with nifedipine (4.3 ± 1.1 ... with saline solution or nifedipine but decreased with verapamil. Peak-positive dP/dt was reduced only by verapamil (from 1,086 ± 175 to 926 ± 167 mm ... was not altered by saline solution, nifedipine, or verapamil. Verapamil reduced the heart rate (from 63 ± 8 ...
Tópico(s): Cardiac pacing and defibrillation studies
1982 - Elsevier BV | The American Journal of Cardiology
Lair G.T. Ribeiro, Tedd A. Brandon, Janet K. Horak, J. Anthony Ware, Richard R. Miller, R. Thomas Solis,
... to play a prominent role in myocardial ischemia. Verapamil, a slow-channel blocking agent with important antiarrhythmic ... particle size analyzer to evaluate the effects of verapamil on platelet aggregation in vitro and in vivo in 88 rats. The intravenous injection of verapamil (0.4 mg/kg) did not change the ... animals receiving an equal volume of normal saline (verapamil, 1.1 ± 0.04 × 106/mm3, vs. control, ... adenosine diphosphate (0.2 μM), was reduced by verapamil (verapamil, 15.3 ± 1.2 × 103 μm3 vs. control ... into the peritoneal cavity, were also smaller following verapamil infusion (verapamil, 12.6 ± 1.1 × 103 μm3, ...
Tópico(s): Acute Myocardial Infarction Research
1982 - Lippincott Williams & Wilkins | Journal of Cardiovascular Pharmacology
Joshua Kieval, E Kirsten, Kenneth M. Kessler, Stephen Mallon, Robert J. Myerburg,
HomeCirculationVol. 65, No. 4The effects of intravenous verapamil on hemodynamic status of patients with coronary artery disease receiving propranolol. Free AccessAbstractPDF/EPUBAboutView PDFSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessAbstractPDF/EPUBThe effects of intravenous verapamil on hemodynamic status of patients with coronary artery ... Calcium Salts in the Prevention and Management of Verapamil-Induced Hypotension, Annals of Pharmacotherapy, 10.1345/aph. ...
Tópico(s): Analytical Methods in Pharmaceuticals
1982 - Lippincott Williams & Wilkins | Circulation
Intravenous (IV) verapamil has recently become available in the United States for treatment of supraventricular tachycardia. It will probably be available for oral administration in the near future. Verapamil, a coronary vasodilator, was originally introduced in Germany ... and the United States have demonstrated that IV verapamil is an extremely effective agent for interruption of ... flutter.1Sung RJ Elser B McAllister RG. Intravenous verapamil for termination of re-entrant supraventricular tachycardias: intracardiac ...
Tópico(s): Cardiac electrophysiology and arrhythmias
1982 - Elsevier BV | CHEST Journal
Joel S. Karliner, Harvey Motulsky, Janet Dunlap, Joan Heller Brown, Paul A. Insel,
... be the only mechanism whereby drugs such as verapamil alter myocardial function. We have examined the effect of verapamil on the binding of [3H]prazosin (α1-adrenergic), [ ... β-adrenergic) to membranes prepared from rat heart. Verapamil competed for the binding of these radioligands in ... 3H]prazosin > [3H]QNB > [3H]DHA (K, for verapamil = 0.6 μM, 7 μM, and 72 μM, respectively). Verapamil (10 μM) competitively inhibited [3H]prazosin binding to ... in maximal binding capacity (Bmax). The effect of verapamil on the affinity of [3H]prazosin was completely ...
Tópico(s): Ion channel regulation and function
1982 - Lippincott Williams & Wilkins | Journal of Cardiovascular Pharmacology
David A. Lathrop, J. Roberto Valle-Aguilera, Ronald W. Millard, Winston E. Gaum, David W. Hannon, Paul Francis, Haruaki Nakaya, Arnold Schwartz,
... effects of diltiazem, nisoldipine (a nifedipine derivative) and verapamil on electrical and mechanical activity were studied in ... development were observed. Administration of diltiazem, nisoldipine and verapamil produced complete excitation/contraction uncoupling. The 50 percent ... 10−7M; nisoldipine, 1.4 × 10−8M; and verapamil, 4.2 × 10−8M. The ease with which ... 75 percent for nisoldipine and 90 percent for verapamil. The reductions in tension development were accompanied by ... diltiazem, unchanged by nisoldipine and significantly increased by verapamil. In potassium-depolarized, isoproterenol-restored canine Purkinje fibers ...
Tópico(s): Cardiac Arrhythmias and Treatments
1982 - Elsevier BV | The American Journal of Cardiology
Michael J. Reiter, David G. Shand, Edward L.C. Pritchett,
To compare the effects of intravenous and oral verapamil we examined the prolongation of the PR interval ... interval prolongation was delayed relative to peak plasma verapamil concentration in all patients after the bolus and ... after oral dosing. In all 11 patients oral verapamil was less potent than a single intravenous bolus of verapamil; the plasma verapamil concentration corresponding to a 10% prolongation of the ... However, there was no such difference between oral verapamil and an infusion in six patients. The plasma ...
Tópico(s): Pharmacological Effects and Toxicity Studies
1982 - Wiley | Clinical Pharmacology & Therapeutics
P. Anderson, Ulf Bondesson, Christer Sylvén, Hans Åström,
... to evaluate the plasma concentration—response relationship for verapamil and one of its metabolites, nor-verapamil. The usual antianginal therapy was discontinued at least ... start of the investigation. During 4 consecutive days verapamil was administered orally in increasing doses, i.e., no verapamil, 40 mg, 80 mg, or 120 mg t. ... In the individual patient the plasma concentration of verapamil increased linearly with the dose given. However, there ... 30-fold interindividual variation in plasma concentrations of verapamil. The ratio norverapamil/verapamil in plasma decreased with ...
Tópico(s): Cardiac pacing and defibrillation studies
1982 - Lippincott Williams & Wilkins | Journal of Cardiovascular Pharmacology
Yuichi Matsushima, Munekazu Gemba,
Effect of verapamil on the organic acid transport was examined with rat kidney cortical slices. Verapamil increased the initial rate of p-aminohippurate (PAH) ... The accumulation of urate was also stimulated by verapamil. D600, a derivative of verapamil, showed the same effect as verapamil with regard to the stimulation of PAH accumulation. Kinetic studies revealed that verapamil resulted in an increase in the Vmax of ... enhanced by aerobic preincubation of the slices with verapamil at 37 degrees C. On the other hand, ...
Tópico(s): Metabolism and Genetic Disorders
1982 - American Society for Pharmacology and Experimental Therapeutics | Journal of Pharmacology and Experimental Therapeutics
Victor S. Wayne, Richard W. Harper, E. Laufer, Jacob Federman, S. T. Anderson, A. Pitt,
... Adverse Interaction Between Beta-adrenergic Blocking Drugs and Verapamil–Report of Three Cases V. S. Wayne, V. ... Adverse interaction between beta-adrenergic blocking drugs and verapamil–report of three cases. V. S. Wayne, R. ... failure, hypotension and bradycardia during combined therapy with verapamil and beta-adrenergic blocking drugs. This clinical picture ... Simultaneous administration of beta-adrenergic blocking drugs and verapamil may result in profound adverse interactions and should ... and Co. 1980: 283–309. 2 Krikler D. Verapamil in cardiology. Eur J Cardiol 1974; 2(1): ...
Tópico(s): Epilepsy research and treatment
1982 - Wiley | Australian and New Zealand Journal of Medicine
V. Bala Subramanian, Michael J. Bowles, Anthony B. Davies, Edward B. Raftery,
... blocking agent propranolol and the calcium channel antagonist verapamil were compared in 22 patients with chronic stable ... randomization to either either 4 weeks' therapy with verapamil, 360 mg/day, or propranolol, 240 nig/day, followed by crossover to the other drug. Both verapamil and propranolol increased exercise tolerance (5.5 ± 0. ... 001], and 9.1 ± 0.5 minutes with verapamil [p <0.001]), but the increase with verapamil was significantly greater (p <0.01). Both drugs ... 001] and 5.5 ±0.6 minutes with verapamil [p <0.001]); the degree of improvement was ...
Tópico(s): Heart Failure Treatment and Management
1982 - Elsevier BV | The American Journal of Cardiology
Janice B. Schwartz, Deborah Keefe, Robert E. Kates, E Kirsten, D C Harrison,
... 65, No. 6Acute and chronic pharmacodynamic interaction of verapamil and digoxin in atrial fibrillation. Free AccessAbstractPDF/EPUBAboutView ... toFree AccessAbstractPDF/EPUBAcute and chronic pharmacodynamic interaction of verapamil and digoxin in atrial fibrillation. J B Schwartz, ... Probe Cocktail Using the Prototypical Inhibitors Rifampin, Probenecid, Verapamil, and Cimetidine, Clinical Pharmacokinetics, 10.1007/s40262-020- ... DETERMINANT OF DRUG INTERACTIONS: THE CASE OF DIGOXIN–VERAPAMIL, Pharmacological Research, 10.1006/phrs.1999.0535, 40: ...
Tópico(s): Plant-based Medicinal Research
1982 - Lippincott Williams & Wilkins | Circulation
Herman O. Klein, Roberto M. Lang, E. Weiß, Elio Di Segni, Carlos D. Libhaber, Julio Guerrero, Elieser Kaplinsky,
The effect of verapamil on the pharmacokinetics of digoxin was studied in 49 patients with chronic atrial fibrillation. A dose of 240 mg/day of verapamil was given to the patients who were receiving ... to 1.31 +/- 0.54 ng/ml during verapamil treatment (p less than 0.0005). This effect ... received 160 mg and then, 240 mg of verapamil: There was a stepwise rise in serum digoxin ... 0.01 for both steps). The effect of verapamil developed gradually within the first few days in ... the increase observed 14 days after onset of verapamil. Renal digoxin clearance decreased significantly (26.1 +/- 0. ...
Tópico(s): Potassium and Related Disorders
1982 - Lippincott Williams & Wilkins | Circulation
Martin B. Leon, Douglas R. Rosing, Robert O. Bonow, Lewis C. Lipson, Stephen E. Epstein,
To determine the effectiveness of oral verapamil alone and combined with propranolol in patients with chronic angina pectoris, upright bicycle exercise testing was performed in 11 patients in an ... 7 minutes (mean ± standard error of the mean), verapamil (480 mg/day) improved exercise time in all ... 1.3 ± 0.6 minutes, p <0.005). Verapamil plus propranolol further increased exercise time (mean increment ... 7 ± 0.7 minutes, p <0.001 versus verapamil alone) and 9 (82 percent) of 11 patients ... 11 with propranolol and 1 of 11 with verapamil). Time to 1 mm S-T segment depression ...
Tópico(s): Muscle activation and electromyography studies
1981 - Elsevier BV | The American Journal of Cardiology