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Artigo Acesso aberto Revisado por pares

Sally N. Adebamowo, Adebowale Adeyemo, Amos Adebayo, Peter Achara, Bunmi Alabi, Rasheed Bakare, Ayo Famooto, Kayode Obende, Richard Offiong, Olayinka Olaniyan, Sanni Ologun, Charles N. Rotimi, Saurayya S. Abdullahi, Maryam Abdulsalam, Ruxton Adebiyi, Victor Adekanmbi, Bukunmi Adelekun, Segun Adeyemo, Gerald Akabueze, Bernice Akpobome, Stella Akpomiemie, Gabriel O. Alabi, Chinyere Anichebe, Claire Anyanwu, Miriam C. Ayogu, Dorcas J. Bako, Patience Bamisaiye, Nkechi U. Blessing, Osa A. Chinye, Patrick Dakum, Eileen Dareng, Grace Dwana, Juliet I. Erhunmwonsere, Emelda O. Eze, Tolani A. Fagbohun, Temitope Filade, Toluwalope Gbolahan, Gloria C. Anaedobe, Stella Ibezim, Racheal Iwaloye, Jesse James, Dayo Kehinde, Fiyinfoluwa Makinde, Jessica Mase, Charles Mensah, Florence A. Nwoko, Kayode Obende, George Odonye, Folake O. Odubore, Funmi Odunyemi, Michael K. Odutola, Uzoamaka Oguama, Tochukwu Oguoma, Temitayo E Oladimeji, Toyosi Olawande, Temitope Olukomogbon, Sefunmi Oluwole, Gladys Omenuko, Nkiruka Onwuka, Yinka Owoade, Thelma C. Ugorji, Syntyche Yohanna, İbrahim Yusuf, Clement Adebamowo,

Abstract Genetic variants that underlie susceptibility to cervical high-risk human papillomavirus (hrHPV) infections are largely unknown. We conducted discovery genome-wide association studies (GWAS), replication, meta-analysis and colocalization, generated polygenic risk scores (PRS) and examined the association of classical HLA alleles and cervical hrHPV infections in a cohort of over 10,000 women. We identified genome-wide significant variants for prevalent hrHPV around LDB2 and for persistent hrHPV ...

Tópico(s): Cancer-related molecular mechanisms research

2024 - Springer Nature | European Journal of Human Genetics