Andrew Robson, Gabriele Marcotti, Phil Yates, Alexi Mostrous, Matthew Elliott Chief Executive, Azmi Keshawi, Andrew Billen, Yepoka Yeebo, Catherine Riley, Paulene Stevenson, Leo Lewis Asia Business Correspondent, Sarah Potter, Gary Duncan, Simon Barnes, Cormac Murphy-O'Connor, Peter Lansley, Mark Souster, Baroness Professor Susan, Professor Peter Braude, David Rose, David Rhys Jones, Tessa Jowell, Philip Howard, Christine Seib, David Chater, Peter lansley, Ben Hoyle Arts Reporter, Bill Cash MP Chairman, John Curtis, James Ducker, Moritz Volz, Roger Helmer MEP Hon Chairman, Sir Gregory Winter, Elizabeth Judge, Sir Martin Evans, Professor David Whittinghan, Carl Mortished, David Charter Europe Correspondent, James Hider, Geoff Brown, Joe Joseph, Robin Pagnamenta, Nick Ross, Ben Webster Transport Correspondent, Professor Anthony J. Pinching, Mark Barrowcliffe, Valerie Elliott Countryside Editor, Frieda Hughes, Donald Hutera, Alison Murdoch, Steve Bird, Robert Halfon Political Director, Gary Jacob, Melanie Reid, Tim Reid, Ruth Gledhill Religion Correspondent, Jeff Stelling Sky Sports presenter, David Sharrock Ireland Correspondent, Hilary Loughran, David Hands, Stephanie Condron, Damon De Laszlo Chairman, Ron Lewis, Adam Sherwin Media Correspondent, Greg Hurst, David Charter, Derwent May, Sir Richard Sykes, Angela Jameson, Suzy Jagger, Oliver Kay, Mark Henderson Science Editor, Neil Harman, John Westerby, Tom Baldwin, Olga Ladushkina, Sam Coates, Eve Thomas, John Hopkins Golf Correspondent, Rob Wright, Edward Gorman Motor Racing Correspondent, Benjani Mwaruwari, Neil Harman Tennis Correspondent, Martin Samuel, Raymond Keene, Christine Buckley, Matthew Pryor, Matt Hughes, Rebecca O'Connor, Robert Oulds Director, Gert Prandstatter, Joseph Stiglitz, Sean O'Neill, Dr Tanya Byron, Nigel Hawkes, Jeremy Page, Chris Campling, Professor Marcus Pembrey, Helen Nugent, Richard Owen, Dr Lyle Armstrong, Peter Dixon, Ron Williams, Carolyn Asome, David Hands Rugby Correspondent, Sir Paul Nurse, Rosemary Bennett Social Affairs Correspondent, Julian Muscat, Paul Simons, Tony Cascarino, Michael Herman, Owen Slot Chief Sports Reporter, B. A. Forbes, Tom Dart, Gerard Baker US Editor, William Rees-Mogg, Nick Szczepanik, Piers Corbyn, Philip Webster Political Editor, Tim Hames, Nile Gardiner Director, Zac Frackelton, Alice Fordham, Donal Blaney Cheif Executive, Anjana Ahuja, George Caulkin, Sonia Verma, Dr Stephen Minger, Caitlin Moran, Walter Gammie, Anthony Loyd, Sarah Jane Checkland, Tony Dawe, H. Rigg, D. N. Stacey, Tim Harford, David Sanderson, Ian Whittell, David Sinclair, Mark Henderson, Sir John Sulston, Lewis Smith Environment Reporter, James Jackson, Patrick Foster, Mark Baldwin, Carl Mortished World Business Editor, Benedict Nightingale, Rick Broadbent Athletics Correspondent, Stephen Dalton, Bill Edgar, Alyson Rudd, J. H. Emlyn Jones, Jim Soar, Owen Slot, Olav Bjortomt, Fiona Hamilton, Richard Beeston Foreign Editor,
... McClaren' O'Neil says US owner is with Vila for long haul Hodgson online Praise for Lerner ...
2008 - Gale Group | TDA
Fábio Luiz Teixeira Gonçalves,
... processo de elaboração e gestão. A Operação Urbana Vila Sônia foi anunciada e apresentada em 2004 e segue ...
Tópico(s): Social and Economic Solidarity
2011 - UNIVERSIDADE DE SÃO PAULO | Estudos Avançados
Jonathan Northcroft, John Dugdale, Philip Marsden, Robert Tchenquiz, Matthew Wall, Barbara Hall, Nigel Botherway, Margie McGregor, Jeff Dawson, Kim Howells, Anthony Everitt, Ian Fraser, Tracey Cox, John Fusco, John White, David Brown, David Canter, Matthew Sturgis, Henry Cooper's, Helen Davies, Rob Hughes, Sir David Attenborough, John Peter, Pam Barrett, Martin James, Mark Hodgkinson, V S, Professor Gideon Garter, Belinda Jones, Amanda Ursell, Jim Munro football editor, Andrew Longmore, Sharon Walker, C H J, J D, Susan d'Arcy, Nick Rufford, Gareth Walsh, Frank Whitford, Chris Kline, Ivo Tennant, Nicolette Jones, Ferdinand Mount, David Gower, Kathryn Cooper, Sam Gilpin, David Smith, John Nutton, Tim Richards, Dave Sones, Peter Sharkey, Steven Poole, Alastair McCall, Neil Wormald, Richard Green, E P, Andrew Sullivan, Clive Davis, Stephen Grey, K R, Tom Evans, C D, Tony Allen-Mills, Simon Wilde, Nick Metcalf, David Sharp, Philip Bellamy, Tom Walker, Anthony Sattin, Alex Clarke, Robert Winnett, Kitty Aldridge, Irwin Stelzer, Adrian Furnham, Robert Hewison, Peter Wilson, John Aiziewood, Sonia Follows, Rosie Millard, Lawrence Dallaglio, David Dougill, Rachel Dobson, Bill Dunn, Philip Kerr, John Page, David Hewson, Alistair Weaver, Cally Law, David Bond, Jonathon Carr-Brown, Hugh Canning, Joe Swift, Nils Pratley, Kathy Harvey, Jeremy Clarkson, Stewart Lee, Edward Porter, Victoria Segal, Louise Taylor, S L, Patricia Nicol, Hilary Clarke, John O'Donnell, Liz Edwards, George Perry, Philip O'Connor, James Delingpole, Adam Nathan, Shelley von Strunckel, Richard Johnson, David S Ware Quartet, Peter Parker, Roger Eglin, Tom Conran, Dominique Coughlin, Steve Waugh, Frances Spalding, Zoe Thomas, Chris Woodhead, Sarah Smith, Lucinda Kemeny, Jasper Gerard, Paul Driver, Boris Schapiro, John Humphrys, Nicholas Hellen, Ian Hawkey, George Melly, Alex Clark, Christopher Morgan, David Leppard, B C, Mark Ludlow, Lisa Grainger, Michael Lynagh, Mark Edwards, Susan Clark, Matthew Sheahan, Eben Black Chief Political Correspondent, Lucy Wakefield, Mary Land, Anthony Perrottet, Lois Rogers, Sean Newsom, David Budworh, Pat O'Connor, Raymond Keene, Robert Winnett Affairs Correspondent, Lisa Ratliffe, Gareth Huw Davies, Douglas Alexander, Stanley Stewart, Cosmo Landesman, Zoe Brennan, Marie Colvin, Gavin Conway, Rachel Holloway, S B, Stephen Jones, Dominic O'Connell, Richard Evans, Uzi Mahnaimi, Nick Cain, Gavin Trewartha, Louise Armitstead, Frankel, Melinda Stevens, Benjys, H Stanley, Caroline Donald, M J, Rob Ryan, Fiona Terry, David Walsh, Peter Coad Director, John Stern, Colin McDowell, Chris Salewicz, Stephen Armstrong, John Elliott, Clare Nolan, Christopher Goodwin, Richard Woods, Roland White, Jack Whittaker, Dina Catchpole, Maurice Chittenden, Jue Lovejoy, Alex Fortune, Charles Lloyd, Richard Rae, Mark Franchetti, Julie Burchill, Craig Lord, Ray Hutton, David Hoppit, Tony Brook, Jonathan Leake, Martin Brayne, Michael Sheridan, D J Taylor, John Harlow, Philip Beresford, Godfrey Smith, Jane Lush, Barry Collins, Dipesh Gadher, John Waples, Marc Zakian, A A Gill, Martin Wright Vice-Chair, Joe Docherty, Matthew Campbell, Brian Glanville, Louise Johncox, Enda Leahy, Iain Milligan, Natalle Graham, Kirsty Lang, Tom Robbins, John Carey, Stella Rimington, Claudia Croft, Jason Mellor, Jonathan Calvert, Patricia Williamson, John Spurling, Rw Johnson, R H, Lindsay Duguild, Sally Kinnes, Naomi Caine, Liam Clarke, David Wickers, Nigel Powell, Caroline Turriff, Brian Doogan, Minette Marrin, Mark Hodson, Graham Norwood, Joe Lovejoy, Jonathan Futrell, Rupert Steiner, David Budworth, Hugh Pearman, D Marsh, Dan Cairns, Paul Stephen Lubicz, Pete Oliver, Simon Sebag Montefiore, David Grylls, Rob Hunter, David Smith Economics Editor, Conal Gregory, Sarah Baxter, Peter Roebuck, Joanna Simon, Matthew Goodman, India Knight, Steve Grant, Kingston Smith, Barry Newcombe, Richard Pym chief executive of Alliance & Leicester, Dominic Rushe, Richard Lewis, Sian Griffiths, Mansieur Mangetout,
... World Class Homes Mallorca Simply Irresistable Living in Vila Sol The Western Algarve Multiple Classified Advertising Items ...
2002 - Gale Group | Sunday Times HA GDA
Federico Mayor, Elisa Lucas, María Jurado-Pueyo, Lucía García‐Guerra, Iria Nieto-Vázquez, Rocío Vila‐Bedmar, Sonia Fernández‐Veledo, Cristina Murga,
... Pueyo, Lucia Garcia-Guerrac, Iria Nieto-Vazquez, Rocio Vila-Bedmar, Sonia Fernández-Veledo & Cristina Murgaa Departamento de Biología Molecular ...
Tópico(s): Neuropeptides and Animal Physiology
2011 - Taylor & Francis | Archives of Physiology and Biochemistry
Produção Nacional
Revisado por pares
... e a execução da Operação Urbana Consorciada Butantã Vila – Sônia (OUCBVS), na região oeste da metrópole de São ... a segregação espacial nos bairros do Butantã e Vila Sônia, analisamos três lugares, caracterizados, predominantemente, por população de ...
Tópico(s): Urban Development and Societal Issues
2014 - Couffy-sur-Sarsonne | Confins
Javier Gómez‐Ambrosi, Victoria Catalán, Amaia Rodrı́guez, Patricia Andrada, Beatriz Ramírez, Patricia Ibáñez Ibáñez, Neus Vila, Sonia Romero, María A. Margall, Marı́a J. Gil, Rafael Moncada, Victor Valentí, Camilo Silva, Javier Salvador, Gema Frühbeck,
It has been suggested that individuals with the condition known as metabolically healthy obesity (MHO) may not have the same increased risk for the development of metabolic abnormalities as their non-metabolically healthy counterparts. However, the validity of this concept has recently been challenged, since it may not translate into lower morbidity and mortality. The aim of the current study was to compare the cardiometabolic/inflammatory profile and the prevalence of impaired glucose tolerance ( ...
Tópico(s): Diabetes, Cardiovascular Risks, and Lipoproteins
2014 - American Diabetes Association | Diabetes Care
Produção Nacional
Revisado por pares
Taissa Vila, Sônia Rozental, Claudia Maria Duarte de Sá Guimarães,
Tópico(s): Fungal Infections and Studies
2014 - Springer Science+Business Media | Lasers in Medical Science
Produção Nacional
Revisado por pares
Gabriela Guerra Leal Souza, Ludmila Naves Magalhães, Thiago Cruz, Ana Carolina Ferraz Mendonça-de-Souza, Antônio Fernando Araújo Duarte, Nastassja Lopes Fischer, Wanderson Fernandes de Souza, Evandro Silva Freire Coutinho, Jaime Vila, Sônia Gleiser, Ivan Figueira, Eliane Volchan,
The body's adaptive reaction to a stressful event, an allostatic response, involves vigorous physiological engagement with and efficient recovery from stress. Our aim was to investigate the influence of individual predispositions on cardiac responses to and recovery from a standardized psychosocial stress task (Trier Social Stress Task) in peacekeepers. We hypothesized that those individuals with higher trait resilience and those with higher resting vagal control would be more likely to present an ...
Tópico(s): Cardiac Health and Mental Health
2013 - Informa | Stress
José Á. García-Sáenz, Begoña Bermejo, Laura García‐Estévez, Andrés García Palomo, Xavier González, Mireia Margelí Vila, Sònia Pernas, Sònia Servitja, César A. Rodríguez, Eva Ciruelos,
Breast cancer is a major public health problem. Despite remarkable advances in early diagnosis and treatment, one in three women may have metastases since diagnosis. Better understanding of prognostic and predictive factors allows us to select the most appropriate adjuvant therapy in each patient. In these guidelines, we summarize current evidence for the medical management of early-stage breast cancer.
Tópico(s): Advanced Breast Cancer Therapies
2015 - Springer Science+Business Media | Clinical & Translational Oncology
Produção Nacional
Revisado por pares
Cristina de Castro Spadari, Taissa Vila, Sônia Rozental, Kelly Ishida,
Cryptococcus spp. are common opportunistic fungal pathogens, particularly in HIV patients.
Tópico(s): Plant-Microbe Interactions and Immunity
2018 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Produção Nacional
Revisado por pares
Luana Pereira Borba-Santos, Taissa Vila, Sônia Rozental,
Sporotrichosis is a neglected endemic mycosis with a high incidence in Latin America, mainly in Brazil. Sporothrix schenckii is the most frequent species in Latin America, whereas Sporothrix brasiliensis is the predominant species observed in Brazil and is associated with both human and animal sporotrichosis. Sporotrichosis treatment remains restricted to a few options, itraconazole being the first choice for human and animal therapy. In this work, we screened the molecular library Pathogen Box ( ...
Tópico(s): Plant Pathogens and Fungal Diseases
2020 - Public Library of Science | PLoS ONE
Natàlia Pérez de la Ossa, Sònia Abilleira, Tudor Jovin, Álvaro García‐Tornel, Xavier Jiménez, Xabier Urra, Pere Cardona, Dolores Cocho, Francisco Purroy, Joaquı́n Serena, Luís San Román, Rosa Maria Vivanco‐Hidalgo, Mercè Salvat‐Plana, Ángel Chamorro, Miquel Gallofré, Carlos A. Molina, Erik Cobo, Antoni Dávalos, Marc Ribó, Jane Abella, Sheila Abrio, Teresa Acera, A Fierro Aguilar, Sonia Aguirre, Laura Alastrue, Consuelo Almodovar, Marne Cristina Alonso, A. Aloy, Mı́riam Álvarez, Miguel Álvarez, Jeannette Alvarez, Celia Alvarin, Maria Vanessa Ameller, Estefania Remedios Andujar, Anna Arambudo, Villagrasa Vilella Ares, Lorena Arrufat, Silvia Auladell, Izaskun Azcárate, Vanessa Aznar, Andrés Baena, Marc Bagaria, J.L. Viejo Bañuelos, Andreu Barnés, Nuria Basany, Cristina Beltrán, Sergio Benavent, Silvia Biesot, Roser Blanch, A. J. Cepillo Boluda, Victor Bonet, Isabel Bonilla, Gemma Borch, Raquel Boullon, N Alejo Bru, Stella Brugues, Estel Buhils, Antonio Burgos, Laia Burnat, S. Fénix Caballero, Jordi Calafell, Miriam Calvet, Arnau Calvo, F. Rodríguez Campo, Olga Campos, Iren Camps, Maria Del Mar Campuzano, Bresme Nuria Cano, Montserrat Capdevila, Antonio Carballo, Daniel Carcelen, Jaume Cardus, Francisco Jose Carmona, M. Caro, Clara Isabel Carre, Alexander Carretero, Gemma Casajuana, Teresa Casasas, C. Castanedo, Maria Gloria Castello, Paramio Castillo, G. Diéguez Castrillo, Rosa Maria Castro, M Elena Castro, Xavier Català, Monica Catells, Dolors Catena, Sergio Cazorla, Sandra Cerdeña, Alexandre Chacon, Sunyer Claustre, Enric Clave, Alejandro Closa, E Seder Colomina, Montserrat Comes, L.E. Cora, E Saez De Buruaga Corrales, Lidia Cortes, Rita Cortit, Pere Lluis Cregut, Nuria Daroca, Carles Delhomme, Anna Delofeu, Carlos Descalzo, Anna Deulofeu, Maneiro Andrea Lucia Diaz, Carmen E. Díaz, Herrero Navarro Diego, Cucurell Navarro Diego-Javier, Dolores Vilas, Espinosa Vivas Dolores, Palau M Carme Domenech, Pablo Durán, Marquez Laura Duran, Martin Pau Escoda, Juan Antonio Escorcia, Maria del Mar Escudero, Jaime Español, Agusti Español, Rodriguez Roger Espases, Resa F Xavier Espert, Tio Vilamala Ester, Casanovas David Esteve, Sanjuan Joan Pere Fabregat, Perez Patricia Fernandez, Perez Daniel Fernandez, Gomez Carlos Fernandez, Alvarez Joaquin Fernandez, Silvia Elena Huatangari Fernández, Quintero Sergi Ferre, Yolanda Ferreres, Casanova Sylvia Figueras, Escobar Sergio Flores, Anna Fontcuberta, Ana Fontquerni, Joan Antoni Forés, Maria Luisa Fortes, Africa Fortes, Espinosa Laura Franch, Romero Maria Teresa Franco, Quesada Sara Maria Franco, Graells Cristina Freixes, Francisco Rut Gallego, Vilches Agusti Galobardes, De Lacanal Carles Galup, Gala Alicia Gamiz, Tortajada Georgina Garcia, Rodriguez Marina Garcia, Plaza Marta Garcia, Lopez Pascual Luis Garcia, Castañeda Laura Garcia, Gallego Ainhoa Garcia-Marron, Faure Helena Gil, Herrera Juan Carlos Gomez, Girbau Xavier Gomez, Arroyo Manuela Gomez, Muñoz Carlos Gonzalez, Lugo Jordi Gonzalez, Lopez Flor Gonzalez, Ricardo Mata González, Marta González-Hernández, Gomez Albert Gonzalez, Fernandez Beatriz Gonzalez, Llesera Daniel Gracia, Gallego Azahara del Mar Grajera, Obeso Maria Gual, B Guerrero, Roca Susana Guillemas, Gimenez Cristina Havernia, Ventura Elena Hernaez, Simancas Rafael Hernandez, Sebastia Gemma Hernandez, Luque Sar Hernandez, Lendinez Jorge Herrada, Perez Luis Herrero, Prades Sergio Hijazo, Covas Dolça Homar, Pérez Honey, Alvarez Lluis Hostench, Royo Marta Huerta, B. Ibañez, A Inio, Cruz Marta Izquiero, Armas Sonia Jaraba, Ramos Pedro Jimenez, Delgado Sonia Jimenez, L Jodar, Gimenez Jordi Juárez, Gil Vázquez, Fuster Pedro Lanau, Gasco Gustavo Laparra, Moreales Anna Lara, Arroyo Dulcenombre de Jesus Las, Medina Maria Lourdes Lasaosa, Sanz Pilar Laserreta, Cava Aida Lazaro, Vidal Monica Llambrich, Yuste Samuel Lopez, Ramirez Cristian Lopez, Ortega Joel Lopez, Oganissian Aleix Lopez, Lopez Anabel Lopez, Lopez Alejandro Lopez, Gomariz Alfonso Lopez, Diaz Enric Lopez, Canela M Angeles Lopez, Romero Pedro López, Maturana Laura López, Villanueva Marta Lozano, Nicola Alexia Lujan, D. Madrid, Romero M Rosa Madrona, Gay M Angel Mallafre, Cortes Jose Marimon, Orive Felix Marrodan, Rovira Rafael Marti, Clemente Albert Marti, R Martin, Bosch Maria Jose Martin, Quesada Martinez, Millan Daniel Martinez, Gonzalez Paula Martinez, Gamez David Martinez, Castaño David Natanael Martinez, Morón Marta Martínez, Medina Marta Martínez, Lopez Manuel Martorell, Fusté Mireia Conillera M Marzà, Barrera Sergi Mayol, Cano Daniel Jesus Megias, Lasheras Marta Melendo, Pi Xavier Mercader, Dalmau Isabel Merino, Mestre Jordi Miralles, Guri Carles Miralles, Balasa Mircea, Corral Jordi Monllao, Ponce Arich Montasell, Sospedra Susana Montesinos, del Carpio Montgomery, Vives M Angela Mora, Ponce Christian Morales, de la Cruz Raquel Morales, Alvarez Jorge Arnulfo Morales, Fornieles Olga Morell, Sanchez Francisco Javier Moreno, Jimenez Sandra Moreno, Blanco Arantxa Moreno, Vivet Mireia Morera, C Morera, Martinez Raul Moya, Hernandez Ricardo Muliterno, Souza Guillem Mundi, Rico Matilde Muñoz, Quiles Aldara Muñoz, Oliva Eva Muñoz, Herrera M Isabel Muñoz, A. Cabello Muriel, Jessica Navarro Rodriguez, Rosa Natalia Navea, Iglesias M Asuncion Neira, Blanco Nerea, Ibañez Rita Maria Nogales, Viera Raquel Novillo, Manrique Maria Pilar Nuñez, Martinez Judith Obiols, Gonzalez Albert Obiols, F. Ocaña, Maisterra Olga, S. P. Olivares, C Olive, Orgaz Marcos Orejuela, B. Oriol, A. Oriol, Bernal Bàrbara Palau, Reig Roger Pallares, Reyes Juan Manuel Palmero, Lozano Ricardo Pardo, Torrabadella Mari Alba Parella, Torres Xenia Partegas, Berengueras Ivana Pascual, Barrameda Feliciano Penela, Villar Carla Montserrat Pera, Sole Pedro Perez, Restrepo Maria Alejandra Perez, Oset Mireia Perez, Gamez Anna Perez, Suazo Núria Piñana, Yeste Raquel Planas, Mangado Anna Planells, Palome Planels, Pujol Ramon Pons, M. Pons, Conde Camilo Postius, Arruñada Jose Antonio Prieto, Ajenjo Monica Prieto,
Importance In nonurban areas with limited access to thrombectomy-capable centers, optimal prehospital transport strategies in patients with suspected large-vessel occlusion stroke are unknown. Objective To determine whether, in nonurban areas, direct transport to a thrombectomy-capable center is beneficial compared with transport to the closest local stroke center. Design, Setting, and Participants Multicenter, population-based, cluster-randomized trial including 1401 patients with suspected acute ...
American Medical Association
Mireia Margelí Vila, Sonia del Barco Berrón, Miguel Gil‐Gil, Cristian Ochoa, Rafael Villanueva-Vázquez,
Metastatic breast cancer (MBC) diagnosis in young women negatively impacts on quality of life (QoL) and daily activities, disrupting their life project and forcing them to face new psychosocial challenges. The recently published results on the improvement of the overall survival of pre- or perimenopausal women with hormone-receptor-positive, HER2-negative MBC treated with CDK4/6 inhibitors plus endocrine therapy, while preserving, and in some items improving their QoL, will change the landscape of ...
Tópico(s): Cancer Treatment and Pharmacology
2020 - Elsevier BV | The Breast
Guillem Pascual‐Pasto, Nagore G. Olaciregui, Mònica Vilà-Ubach, Sonia Paco, Carles Monterrubio, Eva Rodríguez, Ursula Winter, Mireia Batalla-Vilacis, Jaume Catalá, Héctor Salvador, Andreu Parareda, Paula Schaiquevich, Mariona Suñol, Jaume Mora, Cinzia Lavarino, Carmen de Torres, Guillermo Chantada, Ángel M. Carcaboso,
Translational research in retinoblastoma – a pediatric tumor that originates during the development of the retina – would be improved by the creation of new patient-derived models. Using tumor samples from enucleated eyes we established a new battery of preclinical models that grow in vitro in serum-free medium and in vivo in immunodeficient mice. To examine whether the new xenografts recapitulate human disease and disseminate from the retina to the central nervous system, we evaluated their histology ...
Tópico(s): Glioma Diagnosis and Treatment
2016 - Elsevier BV | Cancer Letters
Tiffany S. Pinho, Diogo Vila Verde, Sónia C. Correia, Susana Cardoso, Paula I. Moreira,
Since the first clinical case reported more than 100 years ago, it has been a long and winding road to demystify the initial pathological events underling the onset of Alzheimer’s disease (AD). Fortunately, advanced imaging techniques extended the knowledge regarding AD origin, being well accepted that a decline in brain glucose metabolism occurs during the prodromal phases of AD and is aggravated with the progression of the disease. In this sense, in the last decades, the post-translational modification ...
Tópico(s): Lysosomal Storage Disorders Research
2018 - Elsevier BV | Ageing Research Reviews
Pilar Vila‐Donat, Sonia Marı́n, Vicente Sanchís, Antonio J. Ramos,
Contamination of animal feed with mycotoxins still occurs very often, despite great efforts in preventing it. Animal feeds are contaminated, at low levels, with several mycotoxins, particularly with those produced by Aspergillus and Fusarium genera (Aflatoxin B1, Ochratoxin A, Zearalenone, Deoxynivalenol and Fumonisina B1). In animal feed, to date, only Aflatoxin B1 is limited through EU regulation. Consequently, mycotoxins cause serious disorders and diseases in farm animals. In 2009, the European ...
Tópico(s): Plant Disease Resistance and Genetics
2018 - Elsevier BV | Food and Chemical Toxicology
Pilar Vila‐Donat, Sonia Marı́n, Vicente Sanchís, Antonio J. Ramos,
In the present work different clays have been characterized according to their mycotoxins adsorbent ability. Firstly, 27 bentonite clays from different geographical origins were evaluated, at 0.02% w/v, using an in vitro screening method versus five mycotoxins (aflatoxin B1, AFB1; deoxynivalenol, DON; ochratoxin A, OTA; fumonisin B1, FB1; and, zearalenone, ZEN) by Enzyme-Linked Immunosorbent Assay (ELISA). Subsequently, 7 bentonite clays (6 of which were tri-octahedral bentonites) selected from the ...
Tópico(s): Immunotoxicology and immune responses
2019 - Elsevier BV | Animal Feed Science and Technology
Javier Gómez‐Ambrosi, Victoria Catalán, Amaia Rodrı́guez, Patricia Andrada, Beatriz Ramírez, Patricia Ibáñez Ibáñez, Neus Vila, Sonia Romero, María A. Margall, Marı́a J. Gil, Rafael Moncada, Víctor Valentí, Camilo Silva, Javier Salvador, Gema Frühbeck,
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2014 - American Diabetes Association | Diabetes Care
Pilar Vila‐Donat, Sonia Marı́n, Vicente Sanchís, Antonio J. Ramos,
In 2009 the EU Regulation 386/2009 established a new functional group of feed additives called "substances for reduction of the contamination of feed by mycotoxin". Later, di-octahedral bentonite (1 m558) was authorised, as an anti-aflatoxin additive, being the only additive of this group authorised to date. This work aims to demonstrate the effectiveness of other bentonites, such as tri-octahedral bentonites, versus Fusarium-mycotoxins, since very few adsorbents have proved their effectiveness in ...
Tópico(s): Plant Disease Management Techniques
2020 - Taylor & Francis | Food Additives & Contaminants Part A
Francisco Ayala de la Peña, Raquel Andrés, José Á. García-Sáenz, Luís Manso, Mireia Margelí Vila, E. Dalmau, Sònia Pernas, Aleix Prat, Sònia Servitja, Eva Ciruelos,
Breast cancer is the most common cancer in women in our country and it is usually diagnosed in the early and potentially curable stages. Nevertheless, around 20–30% of patients will relapse despite appropriate locoregional and systemic therapies. A better knowledge of this disease is improving our ability to select the most appropriate therapy for each patient with a recent diagnosis of an early stage breast cancer, minimizing unnecessary toxicities and improving long-term efficacy.
Tópico(s): Advanced Breast Cancer Therapies
2018 - Springer Science+Business Media | Clinical & Translational Oncology
María Agustina Vila, Viktoria Steck, Sonia Rodrı́guez, Ignacio Carrera, Rudi Fasan,
Expanding the reaction scope of natural metalloenzymes can provide new opportunities for biocatalysis. Mononuclear non-heme iron-dependent enzymes represent a large class of biological catalysts involved in the biosynthesis of natural products and catabolism of xenobiotics, among other processes. Here, we report that several members of this enzyme family, including Rieske dioxygenases as well as α-ketoglutarate-dependent dioxygenases and halogenases, are able to catalyze the intramolecular C-H amination ...
Tópico(s): Pharmacogenetics and Drug Metabolism
2020 - Wiley | ChemBioChem
José Á. García-Sáenz, Isabel Blancas, Isabel Echavarría, Carmen Hinojo, Mireia Margelí Vila, Fernando Moreno, Sònia Pernas, Teresa Ramón y Cajal, Nuria Ribelles, Meritxell Bellet,
Abstract Advanced breast cancer represents a challenge for patients and for physicians due its dynamic genomic changes yielding to a resistance to treatments. The main goal is to improve quality of live and survival of the patients through the most appropriate subsequent therapies based on the knowledge of the natural history of the disease. In these guidelines, we summarize current evidence and available therapies for the medical management of advanced breast cancer.
Tópico(s): Breast Cancer Treatment Studies
2023 - Springer Science+Business Media | Clinical & Translational Oncology
Manuel Helbig, Tobias Gerken, Eric Beamesderfer, Dennis Baldocchi, Tirtha Banerjee, Sébastien Biraud, William O. Brown, N. A. Brunsell, Elizabeth A. Burakowski, Sean P. Burns, Brian Butterworth, Stephen Chan, K. J. Davis, Ankur R. Desai, José D. Fuentes, David Y. Hollinger, Natascha Kljun, Matthias Mauder, Kimberly A. Novick, John M. Perkins, David A. Rahn, Camilo Rey‐Sánchez, Joseph A. Santanello, Russell L. Scott, Bijan Seyednasrollah, Paul C. Stoy, Ryan C. Sullivan, Jordi Vilà-Guerau De Arellano, Sonia Wharton, Chuixiang Yi, Andrew D. Richardson,
The atmospheric boundary layer mediates the exchange of energy, matter, and momentum between the land surface and the free troposphere, integrating a range of physical, chemical, and biological processes and is defined as the lowest layer of the atmosphere (ranging from a few meters to 3 km). In this review, we investigate how continuous, automated observations of the atmospheric boundary layer can enhance the scientific value of co-located eddy covariance measurements of land-atmosphere fluxes of ...
Tópico(s): Meteorological Phenomena and Simulations
2021 - Elsevier BV | Agricultural and Forest Meteorology
Produção Nacional
Revisado por pares
Eduardo Donizeti Girotto, Larissa de Campos,
... escolar na área que abrange a Operação Urbana Vila Sônia, na Zona Oeste da cidade de São Paulo. ...
Tópico(s): Urban Development and Societal Issues
2020 - UNIVERSIDADE FEDERAL DE SANTA MARIA | Geografia Ensino & Pesquisa
Produção Nacional
Revisado por pares
Miguel Martín, Amparo Ruiz Simón, Manuel Ruíz Borrego, Nuria Ribelles, Álvaro Rodríguez-Lescure, Montserrat Muñoz, Sonia González, Mireia Margelí Vila, Agustí Barnadas, Manuel Ramos, Sonia del Barco Berrón, Carlos Jara, Lourdes Calvo, Noelia Martínez-Jáñez, César Mendiola Fernández, César A. Rodríguez, Eduardo Martínez de Dueñas, R. Andrés, Arrate Plazaola, Juan de la Haba-Rodríguez, José Manuel López-Vega, Encarna Adrover, Ana Isabel Ballesteros, Ana Santaballa, Pedro Sánchez‐Rovira, José Manuel Baena-Cañada, Maribel Casas, María del Carmen Cámara, Eva Carrasco, Aña Lluch,
Capecitabine is an active drug in metastatic breast cancer (BC). GEICAM/2003-10 is an adjuvant trial to investigate the integration of capecitabine into a regimen of epirubicin and docetaxel for node-positive early BC.Patients with operable node-positive BC (T1-3/N1-3) were eligible. After surgery, 1,384 patients were randomly assigned to receive epirubicin plus cyclophosphamide (EC; 90 and 600 mg/m(2), respectively, × four cycles), followed by docetaxel (100 mg/m(2) × four cycles; EC-T) or epirubicin plus ...
Tópico(s): Colorectal Cancer Treatments and Studies
2015 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Produção Nacional
Revisado por pares
Taissa Vila, Rashid Nazir, Sônia Rozental, Giulia Maria Pires dos Santos, Renata Calixto, Eliana Barreto‐Bergter, Lukas Y. Wick, Jan Dirk van Elsas,
The soil bacterium Burkholderia terrae strain BS001 can interact with varying soil fungi, using mechanisms that range from the utilization of carbon/energy sources such as glycerol to the ability to reach novel territories in soil via co-migration with growing fungal mycelia. Here, we investigate the intrinsic properties of the B. terrae BS001 interaction with the basidiomycetous soil fungus Lyophyllum sp. strain Karsten. In some experiments, the ascomycetous Trichoderma asperellum 302 was also ...
Tópico(s): Protist diversity and phylogeny
2016 - Frontiers Media | Frontiers in Microbiology
Laura López-Fuertes, Eva Perez‐Jimenez, Antonio J. Vila‐Coro, Florian Sack, Sonia Carreño-Moreno, Sabine König, Claas Junghans, B. Wittig, Marcos Timón, Mariano Estéban,
Immunization protocols based on priming with plasmid DNA and boosting with recombinants of vaccinia virus (rVV) encoding the same antigen offer great promise for the prevention and treatment of many parasitic and viral infections for which conventional vaccination has little or no effect. To overcome some of the potential problems associated to the use of plasmids, we have developed minimalistic, immunogenically defined, gene expression (MIDGE®) vectors. These linear vectors contain only the minimum ...
Tópico(s): Virus-based gene therapy research
2002 - Elsevier BV | Vaccine
Rocío Vila‐Bedmar, Margarita Lorenzo, Sonia Fernández‐Veledo,
Brown adipose tissue (BAT) is considered of metabolic significance in mammalian physiology, because it plays an important role in regulating energy balance. Alterations in this tissue have been associated with obesity and type 2 diabetes. The molecular mechanisms modulating brown adipocyte differentiation are not fully understood. Using a murine brown preadipocyte cell line, primary cultures, and 3T3-L1 cells, we analyzed the contribution of various intracellular signaling pathways to adipogenic ...
Tópico(s): Mitochondrial Function and Pathology
2010 - Oxford University Press | Endocrinology
Produção Nacional
Revisado por pares
Taissa Vila, Ashok K. Chaturvedi, Sônia Rozental, José L. López-Ribot,
ABSTRACT The generation of a new antifungal against Candida albicans biofilms has become a major priority, since biofilm formation by this opportunistic pathogenic fungus is usually associated with an increased resistance to azole antifungal drugs and treatment failures. Miltefosine is an alkyl phospholipid with promising antifungal activity. Here, we report that, when tested under planktonic conditions, miltefosine displays potent in vitro activity against multiple fluconazole-susceptible and -resistant ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2015 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Produção Nacional
Revisado por pares
Taissa Vila, Natália Sousa Quintanilha, Sônia Rozental,
Onychomycosis is a fungal nail infection that represents ∼50 % of all nail disease cases worldwide. Clinical treatment with standard antifungals frequently requires long-term systemic therapy to avoid chronic disease. Onychomycosis caused by non-dermatophyte moulds, such as Fusarium spp., and yeasts, such as Candida spp., is particularly difficult to treat, possibly due to the formation of drug-resistant fungal biofilms on affected areas. Here, we show that the alkylphospholipid miltefosine, used clinically ...
Tópico(s): Antifungal resistance and susceptibility
2015 - Microbiology Society | Journal of Medical Microbiology