Lobo de Barbosa Ferreira Teixera Girão, Antonio, visconde de Villarinho de São Romão,
Book.
0000 - Gale Group | The Making of Modern World
Produção Nacional
Revisado por pares
Fúlvio Pileggi, José Bocanegra, João Tranchesi, R Macrúz, Silvio Borges, O Portugal, Manuel G. Villarinho, Ennio Barbato, Luiz V. Décourt,
One hundred and forty-two cases of tetralogy of Fallot were studied from both the scalar and the vectorial electrocardiographic points of view. We have concluded that in the majority of the cases of this congenital heart disease the ECG shows a uniform behavior which relates to the hemodynamic picture. We have established the criteria for the diagnosis of the left ventricular enlargement which may eventually co-exist, indicating a predominant left-to-right shunt through the interventricular septal ...
Tópico(s): Cardiac Arrhythmias and Treatments
1960 - Elsevier BV | American Heart Journal
Produção Nacional
Revisado por pares
Luciana Villarinho, Ivanilda Cavalcanti Bezerra, Regina Lacerda, Maria do Rosário Dias de Oliveira Latorre, Vera Paiva, Ron Stall, Norman Hearst,
OBJETIVO: Descrever a vulnerabilidade, de caminhoneiros de rota curta, à transmissão sexual do HIV e da Aids. MÉTODOS: Foram entrevistados 279 caminhoneiros com vínculo de trabalho na cidade de Santos, SP, em locais de concentração na área portuária e suas proximidades, sindicatos e associações, recrutados pela amostragem do tipo "bola-de-neve". Foram realizadas entrevistas utilizando perguntas abertas e fechadas sobre questões sociodemográficas, práticas sexuais, uso de drogas, conhecimento sobre ...
Tópico(s): HIV/AIDS Research and Interventions
2002 - UNIVERSIDADE DE SÃO PAULO | Revista de Saúde Pública
Produção Nacional
Revisado por pares
Cristiane Lenz Dalla Corte, Roselei Fachinetto, Dirleise Colle, Romaiana Picada Pereira, Daiana Silva Ávila, Jardel Gomes Villarinho, Caroline Wagner, Maria Estér Pereira, Cristina W. Nogueira, Félix Alexandre Antunes Soares, João Batista Teixeira da Rocha,
This study was designed to determine whether the treatment with haloperidol (HP), valerian or both in association impairs the liver or kidney functions. Valerian alone did not affect oxidative stress parameters in the liver or kidney of rats. HP alone only increased glutathione (GSH) depletion in liver, but not in kidney. However, when HP was associated with valerian, an increase in lipid peroxidation levels and dichlorofluorescein (DCFH) reactive species production was observed in the hepatic tissue. ...
Tópico(s): Tryptophan and brain disorders
2008 - Elsevier BV | Food and Chemical Toxicology
Produção Nacional
Revisado por pares
Yolanda Karla Cupertino da Silva, Cristina Villarinho Augusto, Maria Letícia de Castro Barbosa, Gabriela Muniz de Albuquerque Melo, Aline Cavalcanti de Queiroz, Thays de Lima Matos Freire Dias, Walfrido Bispo Júnior, Eliezer J. Barreiro, Lı́dia Moreira Lima, Magna Suzana Alexandre‐Moreira,
In this paper, we report the synthesis and pharmacological evaluation of pyrazine N-acylhydrazone (NAH) derivatives (2a–s) designed as novel analgesic and anti-inflammatory drug candidates. This series was planned by molecular simplification of prototype 1 (LASSBio-1018), previously described as a non-selective cyclooxygenase inhibitor. Derivatives 2a–s were evaluated in several animal models of pain and inflammation, standing-out compound 2o (2-N′-[(E)-(3,4,5-trimethoxyphenyl) methylidene]-2-pyrazinecarbohydrazide; ...
Tópico(s): Synthesis and Characterization of Heterocyclic Compounds
2010 - Elsevier BV | Bioorganic & Medicinal Chemistry
Produção Nacional
Revisado por pares
A. Teixeira, Liz Girardi Müller, Patrícia Reckziegel, N. Boufleur, Camila Simonetti Pase, Jardel Gomes Villarinho, Roselei Fachinetto, Juliano Ferreira, João Batista Teixeira da Rocha, Marilise Escobar Bürger,
Here we evaluate the influence of a new exercise protocol on movement disorders induced by neuroleptic drugs. In this animal model, involuntary movements are closely related to neuronal degeneration and oxidative stress (OS) that can be caused by pre-synaptic D2 receptor blockade increasing dopamine (DA) metabolism. The increase in vacuous chewing movements (VCM) and the reduced locomotor activity induced by haloperidol treatment (12 mg/kg-im, once a week for 4 weeks) was prevented by exercise, 5 times ...
Tópico(s): Neuroscience and Neuropharmacology Research
2010 - Elsevier BV | Neuropharmacology
Produção Nacional
Revisado por pares
Mateus Rossato, Gabriela Trevisan, Cristiani Isabel Banderó Walker, Jonatas Zeni Klafke, Ana Paula de Oliveira, Jardel Gomes Villarinho, Ricardo Basso Zanon, Luiz Fernando Freire Royes, Margareth Linde Athayde, Marcus V. Gomez, Juliano Ferreira,
The transient potential vanilloid 1 receptor (TRPV1) is a calcium-permeable channel responsible for the transduction and modulation of acute and chronic pain signaling. As such, this receptor is a potential target for the treatment of a number of pain disorders. However, AMG517, a TRPV1 antagonist, presents several clinical limitations that include the induction of severe hyperthermia. The aim of this study was to investigate the possible interaction of the flavonoid eriodictyol with the TRPV1 receptor ...
Tópico(s): Herbal Medicine Research Studies
2010 - Elsevier BV | Biochemical Pharmacology
Produção Nacional
Eduardo Luiz Gasnhar Moreira, Daniel Rial, Aderbal S. Aguiar, Cláudia P. Figueiredo, Jarbas Mota Siqueira, Silvia DalBó, Heros Horst, Jade de Oliveira, Gianni Mancini, Tiago Souza dos Santos, Jardel Gomes Villarinho, F.V. Pinheiro, José Marino–Neto, Juliano Ferreira, Andreza Fabro de, Alexandra Latini, Moacir Geraldo Pizzolatti, Rosa Maria Ribeiro‐do‐Valle, Rui Daniel Prediger,
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2010 - Springer Science+Business Media | Journal of Neural Transmission
Produção Nacional
Revisado por pares
Roselei Fachinetto, Jardel Gomes Villarinho, Caroline Wagner, Romaiana Picada Pereira, Robson Luiz Puntel, Márcio W. Paixão, Antônio L. Braga, João Β. Calixto, João Batista Teixeira da Rocha, Juliano Ferreira,
Tópico(s): Tryptophan and brain disorders
2007 - Springer Science+Business Media | Psychopharmacology
Produção Nacional
Revisado por pares
Roselei Fachinetto, Jardel Gomes Villarinho, Caroline Wagner, Romaiana Picada Pereira, Daiana Silva Ávila, Marilise Escobar Bürger, João Β. Calixto, João Batista Teixeira da Rocha, Juliano Ferreira,
Chronic treatment with classical neuroleptics in humans can produce a serious side effect, known as tardive dyskinesia (TD). Here, we examined the effects of V. officinalis, a medicinal herb widely used as calming and sleep-promoting, in an animal model of orofacial dyskinesia (OD) induced by long-term treatment with haloperidol. Adult male rats were treated during 12 weeks with haloperidol decanoate (38 mg/kg, i.m., each 28 days) and with V. officinalis (in the drinking water). Vacuous chewing movements ( ...
Tópico(s): Olfactory and Sensory Function Studies
2007 - Elsevier BV | Progress in Neuro-Psychopharmacology and Biological Psychiatry
Produção Nacional
Revisado por pares
Ana Elisa da Silva, Pantelis Varvaki Rados, Isabel da Silva Lauxen, Luhana Gedoz, Eduardo Aydos Villarinho, Vânia Regina Camargo Fontanella,
This study aimed to investigate the effect of radiation from panoramic radiographs on the cells of the lateral border of the tongue by evaluating nuclear changes. Forty-two patients were included: 22 had one radiograph (Group I), and 20 required a repeat radiograph due to error in the first exposure (Group II). Material for the cytopathologic evaluation was collected before radiographs and 10 days later. Smears were stained with the Feulgen reaction and micronuclei, buds, broken eggs, karyorrhexis ...
Tópico(s): Radioactive contamination and transfer
2007 - Elsevier BV | Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Produção Nacional
Revisado por pares
Raquel Tonello, Jardel Gomes Villarinho, Gabriela da Silva Sant’Anna, Lidia La Rocca Tamiozzo, Pablo Machado, Gabriela Trevisan, Marcos A. P. Martins, Juliano Ferreira, Maribel Antonello Rubin,
The compound 2-(2-benzofuranyl)-2-imidazoline (2-BFI) is a 2-imidazoline derivative that selectively inhibits the in vitro activity of monoamine oxidase-A and it is also an imidazoline I(2) agonist. However, the antidepressant potential of this compound and its mechanism of action have not been well defined. Therefore, in this study we investigated the antidepressant-like effect of 2-BFI in mice. 2-BFI (100 and 300μmol/kg, s.c.) significantly reduced the immobility time on the tail suspension test ( ...
Tópico(s): Tryptophan and brain disorders
2011 - Elsevier BV | Progress in Neuro-Psychopharmacology and Biological Psychiatry
Produção Nacional
Revisado por pares
Rodrigo Bernardo Serafim, Maximiliano F Dutra, Felipe Saddy, Bernardo Rangel Tura, Jose Eduardo Couto de Castro, Luciana C Villarinho, Maria da Gloria Santos, Fernando A. Bozza, José Rodolfo Rocco,
Delirium features can vary greatly depending on the postoperative population studied; however, most studies focus only on high-risk patients. Describing the impact of delirium and risk factors in mixed populations can help in the development of preventive actions.The occurrence of delirium was evaluated prospectively in 465 consecutive nonventilated postoperative patients admitted to a surgical intensive care unit (SICU) using the confusion assessment method (CAM). Patients with and without delirium ...
Tópico(s): Anesthesia and Neurotoxicity Research
2012 - Springer Nature | Annals of Intensive Care
Produção Nacional
Revisado por pares
Jardel Gomes Villarinho, Roselei Fachinetto, Francielle de Vargas Pinheiro, Gabriela da Silva Sant’Anna, Pablo Machado, Patrícia A. Dombrowski, Cláudio Da Cunha, Daniela Almeida Cabrini, Marcos A. P. Martins, Hélio G. Bonacorso, Nilo Zanatta, Maribel Antonello Rubin, Juliano Ferreira,
Monoamine oxidase (MAO) inhibitors were the first antidepressant drugs to be prescribed and are still used today with great success, especially in patients resistant to other antidepressants. In this study, we evaluated the MAO inhibitory properties and the potential antidepressant action of 2-(3,4-dimethoxy-phenyl)-4,5-dihydro-1H-imidazole (2-DMPI) in mice. We found that 2-DMPI inhibited both MAO isoforms (K(i) values were 1.53 (1.3-1.8) μM and 46.67 (31.8-68.4) μM for MAO-A and MAO-B, respectively) ...
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2012 - Elsevier BV | Progress in Neuro-Psychopharmacology and Biological Psychiatry
Produção Nacional
Revisado por pares
Jonatas Zeni Klafke, Marcelo Aparecido da Silva, Gabriela Trevisan, Mateus Rossato, C.R. da Silva, Gustavo Petri Guerra, Jardel Gomes Villarinho, Flávia Karine Rigo, Gerusa Duarte Dalmolin, Marcus V. Gomez, Maribel Antonello Rubin, Juliano Ferreira,
The transient receptor potential ankyrin 1 (TRPA1) is expressed in peripheral and spinal terminals of sensory neurons, jointly to the vanilloid receptor (TRPV1). A relevant peripheral role of TRPA1 receptor has been implicated in a variety of processes, including the detection of noxious cold, and diverse painful stimulus, but the functional role of TRPA1 receptor in nociceptive transmission at spinal cord in vivo is poorly known. Therefore, the aim of this study was to evaluate whether the glutamatergic ...
Tópico(s): Pain Mechanisms and Treatments
2012 - Elsevier BV | Neuroscience
Produção Nacional
Revisado por pares
Fabrício A. Pamplona, Juliano Ferreira, Octávio Menezes de Lima, Filipe Silveira Duarte, Allisson Freire Bento, Stefânia Forner, Jardel Gomes Villarinho, Luigi Bellocchio, Carsten T. Wotjak, Raissa Lerner, Krisztina Monory, Beat Lutz, Cláudio Canetti, Isabel Matias, João Β. Calixto, Giovanni Marsicano, Marília Zaluar P. Guimarães, Reinaldo Ν. Takahashi,
Allosteric modulation of G-protein–coupled receptors represents a key goal of current pharmacology. In particular, endogenous allosteric modulators might represent important targets of interventions aimed at maximizing therapeutic efficacy and reducing side effects of drugs. Here we show that the anti-inflammatory lipid lipoxin A 4 is an endogenous allosteric enhancer of the CB 1 cannabinoid receptor. Lipoxin A 4 was detected in brain tissues, did not compete for the orthosteric binding site of ...
Tópico(s): Diet, Metabolism, and Disease
2012 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Produção Nacional
Revisado por pares
Filipe C. Matheus, Aderbal S. Aguiar, Adalberto A. Castro, Jardel Gomes Villarinho, Juliano Ferreira, Cláudia P. Figueiredo, Roger Walz, Adair R.S. Santos, Carla I. Tasca, Rui Daniel Prediger,
We have recently demonstrated that rodents treated intranasally with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) suffered impairments in olfactory, cognitive, emotional and motor functions associated with time-dependent disruption of dopaminergic neurotransmission in different brain structures conceivably analogous to those observed during different stages of Parkinson's disease (PD). Agmatine, an endogenous arginine metabolite, has been proposed as a novel neuromodulator that plays protective ...
Tópico(s): Olfactory and Sensory Function Studies
2012 - Elsevier BV | Behavioural Brain Research
Produção Nacional
Revisado por pares
Jardel Gomes Villarinho, Sara Marchesan Oliveira, Cássia Regina Silva, Thaíssa Nunes Cabreira, Juliano Ferreira,
In this study we assessed the involvement of monoamine oxidase B (MAO-B), a key enzyme implicated in monoamine metabolism, on postoperative (plantar incision) and neuropathic (partial sciatic nerve ligation) pain models in mice. Paw incision submitted mice showed a significant decrease in mechanical threshold compared with the sham-operated mice, characterizing the development of mechanical allodynia. The selective and irreversible MAO-B inhibitor selegiline, at a dose sufficient to selectively inhibit ...
Tópico(s): Botulinum Toxin and Related Neurological Disorders
2012 - Elsevier BV | European Journal of Pharmacology
Produção Nacional
Revisado por pares
Francielle de Vargas Pinheiro, Jardel Gomes Villarinho, Cássia Regina Silva, Sara Marchesan Oliveira, Kelly de Vargas Pinheiro, Delia Petri, Mateus Rossato, Gustavo Petri Guerra, Gabriela Trevisan, Maribel Antonello Rubin, Pierangelo Geppetti, Juliano Ferreira, Eunice Andrè,
Sympathetic fibres maintain some forms of neuropathic pain, but the underlying mechanisms are poorly understood. Therefore, this study investigated the possible involvement of transient receptor potential ankyrin 1 (TRPA1) and the role of the sympathetic nervous system (involved in sympathetically maintained neuropathic pain) in a model of neuropathic pain induced by sciatic nerve chronic constriction injury (CCI) in mice. Systemic injection of the selective TRPA1 antagonist HC-030031 reversed the ...
Tópico(s): Neurobiology and Insect Physiology Research
2014 - Elsevier BV | European Journal of Pharmacology
Produção Nacional
Revisado por pares
Luiz Villarinho Pereira Mendes, Mônica Rodrigues Campos, Gabriela Costa Chaves, Rondinelli Mendes da Silva, Paula da Silva Freitas, Karen Sarmento Costa, Vera Lúcia Luiza,
da assistência farmacêutica em particular.
Tópico(s): Healthcare Systems and Reforms
2014 - Centro Brasileiro de Estudos de Saúde | Saúde em Debate
Produção Nacional
Revisado por pares
Tatiana Sobottka SPINI, Fabrício Pinelli Valarelli, Rodrigo Hermont Cançado, Karina Maria Salvatore de Freitas, Denis Jardim Villarinho,
Objectives: The shape memory resulting from the superelasticity and thermoelastic effect is the main characteristic of thermally activated NiTi archwires and is closely related to the transition temperature range (TTR). The aim of this study was to evaluate the TTR of thermally activated NiTi archwires commercially available. Material and Methods: Seven different brands of 0.019"x0.025" thermally activated nickel-titanium archwires were tested as received by differential scanning calorimetry (DSC) ...
Tópico(s): Musicians’ Health and Performance
2014 - UNIVERSIDADE DE SÃO PAULO | Journal of Applied Oral Science
Produção Nacional
Revisado por pares
Jardel Gomes Villarinho, Kelly de Vargas Pinheiro, Francielle de Vargas Pinheiro, Sara Marchesan Oliveira, Pablo Machado, Marcos A. P. Martins, Hélio G. Bonacorso, Nilo Zanatta, Roselei Fachinetto, Juliano Ferreira,
Neuropathic pain is a debilitating condition that is often resistant to common analgesics, such as opioids, but is sensitive to some antidepressants, an effect that seems to be mediated by spinal cord 5-HT3 receptors. Because the analgesic potential of monoamine oxidase-A (MAO-A) inhibitors is understudied, we evaluated the potential antinociceptive effect of the reversible MAO-A inhibitors moclobemide and 2-(3,4-dimethoxy-phenyl)-4,5-dihydro-1H-imidazole (2-DMPI) in a mouse neuropathic pain model ...
Tópico(s): Nerve injury and regeneration
2013 - Elsevier BV | Progress in Neuro-Psychopharmacology and Biological Psychiatry
Produção Nacional
Revisado por pares
Eduardo Aydos Villarinho, André Cervieri, Rosemary Sadami Arai Shinkai, Márcio Lima Grossi, Eduardo Rolim Teixeira,
The biomechanical stability of the implant-abutment connection is critical for the success of implant-supported restorations. This study investigated the effect of a positioning index on the abutment screw preload values of tapered connection implants. Twenty Morse taper implants presenting an internal locking hex received 10 solid and 10 straight screw retained abutments for cemented single-crown restorations. Ten abutments had a positioning index to fit the internal locking hex of the implant ( ...
Tópico(s): Bone Tissue Engineering Materials
2013 - Allen Press | Journal of Oral Implantology
Produção Nacional
Revisado por pares
Mariana Vieira Villarinho, María Itayra Padilha, Lina Márcia Miguéis Berardinelli, Míriam Süsskind Borenstein, Betina Hörner Schlindwein Meirelles, Selma Regina de Andrade,
Objetivou-se identificar as principais políticas públicas sobre HIV/AIDS no cenário brasileiro, a partir de 1980 e refletir sobre seu impacto na assistência às pessoas que convivem com HIV/AIDS. A partir dos descritores políticas públicas de saúde, Síndrome da Imunodeficiência Adquirida e assistência integral à saúde, obtive-se uma amostra de 23 artigos, nas bases de dados Medline e Lilacs. Após análise, verificaram-se dois momentos: o primeiro, do surgimento das políticas públicas em resposta à ...
Tópico(s): Science and Education Research
2013 - Associação Brasileira de Enfermagem | Revista Brasileira de Enfermagem
Produção Nacional
Relative concepts of sustainability are more and more influenced by societies around the world. The construction industry, especially for building construction development, is being accused of promoting environmental impacts that range from excess use of resources to pollution generation. This paper present an application of the sustainability concept applied to buildings, as well as, a contribution to the development of practices, methodology and tools for evaluation of already existing buildings. ...
Tópico(s): Facilities and Workplace Management
2013 - Science Publishing Group | American Journal of Civil Engineering
Produção Nacional
Revisado por pares
Andréia Martini Pazini, Guilherme M. Gomes, Jardel Gomes Villarinho, Cláudio Da Cunha, F.V. Pinheiro, Ana Paula Oliveira Ferreira, Carlos Fernando Mello, Juliano Ferreira, Maribel Antonello Rubin,
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2013 - Springer Science+Business Media | Neurochemical Research
Produção Nacional
Revisado por pares
Mônica Rodrigues Campos, Vanessa dos Reis von Doellinger, Luiz Villarinho Pereira Mendes, Maria de Fátima dos Santos Costa, Thiago Góes Pimentel, Joyce Mendes de Andrade Schramm,
The aim of this study was to estimate the global burden of disease from external causes in 2008 in Brazil, based on DALYs (disability-adjusted life years). YLLs (years of life lost) were estimated according to the method proposed by Murray & Lopez (1996). Meanwhile, the method for estimating YLDs (years lived with disability) included methodological adjustments taking the Brazilian reality into account. The study showed a total of 195 DALYs per 100 thousand inhabitants, of which 19 DALYs were related ...
Tópico(s): Traffic and Road Safety
2015 - Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz | Cadernos de Saúde Pública
Produção Nacional
Revisado por pares
Lucio Villarinho Rosa, Assed Haddad, Paulo Victor Rodrigues de Carvalho,
Tópico(s): Construction Project Management and Performance
2015 - Springer Science+Business Media | Cognition Technology & Work
Produção Nacional
Revisado por pares
Alana Witt Hansen, Lílian Vanessa Rossa Beltrami, Leonardo Marasca Antonini, Denis Jardim Villarinho, Julio Cesar Klein das Neves, Cláudia Eliana Bruno Marino, Célia de Fraga Malfatti,
Several studies regarding superficial treatments of Nitinol (NiTi) shape-memory have been developed aiming to the improve corrosion resistance and to block the Ni release to adjacent tissues. The necessary heat treatment to achieve the shape memory effect normally occurs at temperatures between 500 and 600 °C. However, titanium oxide (TiO2) is formed on the NiTi surface during the shape memory process heat treatment. In this work the effects of the heat treatment time on the surface characteristics ...
Tópico(s): Transition Metal Oxide Nanomaterials
2015 - Associação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímer | Materials Research
Produção Nacional
Revisado por pares
Alana Witt Hansen, Luciane Taís Führ, Leonardo Marasca Antonini, Denis Jardim Villarinho, Cláudia Eliana Bruno Marino, Célia de Fraga Malfatti,
In order to improve the NiTi alloy biocompatibility, surface treatments become very important. Nevertheless, researchers use different solutions to simulate the body fluids in electrochemical assays, and the correlation between the obtained results is difficult and might not even be possible. The present paper evaluated the electrochemical behavior of polished NiTi surfaces exposed to different simulated body fluid solutions: Hanks solution, Hanks’ balanced salt (HBSS) solution, saline body fluid ( ...
Tópico(s): Titanium Alloys Microstructure and Properties
2015 - Associação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímer | Materials Research