Laura Filograna, Guglielmo Manenti, Vincenzo Arena, Marco Dell’Aquila, Vincenzo L. Pascali, Luigi Natale, Cesare Colosimo, Simone Grassi, Roberto Floris, Antonio Oliva,
We present the case of an elderly woman who died from COVID-19 during the first wave of the pandemic. The physicians in charge of the patient were later accused of medical malpractice resulting in the death of the patient. The article reviews the comprehensive medico-legal investigations into this case that included an analysis of the medical history, clinical imaging, post-mortem imaging, autopsy, histopathology, and microbiology as well as an assessment of the medical knowledge regarding transmission ...
Tópico(s): Medical Malpractice and Liability Issues
2021 - Elsevier BV | Forensic Imaging
Alessandro Villa, Mariangela Garofalo, Daniela Crescenti, Nicoletta Rizzi, Electra Brunialti, Andrea Vingiani, Paolo Belotti, Carlo Sposito, Silvia Franzé, Francesco Cilurzo, Giancarlo Pruneri, Camilla Recordati, C. Giúdice, Alessia Giordano, Monica Tortoreto, Giangiacomo Beretta, D. Stefanello, Giacomo Manenti, Nadia Zaffaroni, Vincenzo Mazzaferro, Paolo Ciana,
Nano-and microsized extracellular vesicles (EVs) are naturally occurring cargo-bearing packages of regulatory macromolecules, and recent studies are increasingly showing that EVs are responsible for physiological intercellular communication.Nanoparticles encapsulating anti-tumor theranostics represent an attractive "exosome-interfering" strategy for cancer therapy.Methods: Herein, by labeling plasma-derived EVs with indocyanine green (ICG) and following their biodistribution by in vivo and ex vivo ...
Tópico(s): Circular RNAs in diseases
2020 - Ivyspring International Publisher | Theranostics
Anna Bonardi, Raoul Manenti, Andrea Corbetta, Vincenzo Ferri, David Fiacchini, Giovanni Giovine, Silvia Macchi, Enrico Romanazzi, Christiana Soccini, L. Bottoni, Emilio Padoa‐Schioppa, Gentile Francesco Ficetola,
Measuring a species decline is pivotal to evaluate their conservation status, but an accurate assessment of demographic trends requires observations collected across broad spatial and temporal scales. Volunteers can help to collect information over large scales, but their data may be affected by heterogeneity for sampling efforts and protocols, which may influence detection probability. Ignoring this issue may conduct to misleading conclusions. Here we show that data collected by different volunteer ...
Tópico(s): Species Distribution and Climate Change
2011 - Elsevier BV | Biological Conservation
S Cabibbo, Carmelo Fidone, Giovanni Garozzo, Agostino Antolino, Giovanna Oriella Manenti, Francesco Bennardello, Vincenzo Licitra, Salvatore Calabrese, Francesco Costantino, Simone Travali, Roberto Distefano, Pietro Bonomo,
We tracked the results of 394 manual or automatic red blood cell exchanges done with a cell separator in 20 sickle cell patients at high risk for recurrent complications. Over an average of 6 years, none of the patients developed complications related to the procedure or to the increased blood use. It was safe and effective in preventing complications of sickle cell disease, and if done automatically, reduced iron overload. Ferritin levels also decreased in patients treated with automatic red blood ...
Tópico(s): Erythrocyte Function and Pathophysiology
2005 - Elsevier BV | Transfusion and Apheresis Science
Claudio Bandi, Jairo Alfonso Mendoza‐Roldan, Domenico Otranto, Alessandro Alvaro, Viviane Noll Louzada-Flores, Massimo Pajoro, Ilaria Varotto-Boccazzi, Matteo Brilli, Alessandro Manenti, Emanuele Montomoli, Gian Vincenzo Zuccotti, Sara Epis,
Abstract Parasites of the genus Leishmania are unusual unicellular microorganisms in that they are characterized by the capability to subvert in their favor the immune response of mammalian phagocytes, including dendritic cells. Thus, in overt leishmaniasis, dendritic cells and macrophages are converted into a niche for Leishmania spp. in which the parasite, rather than being inactivated and disassembled, survives and replicates. In addition, Leishmania parasites hitchhike onto phagocytic cells, ...
Tópico(s): Research on Leishmaniasis Studies
2023 - BioMed Central | Parasites & Vectors
Alberto Bruno Ferrari, G Pulcini, Federico Gheza, A Vinco, Stefania Manenti, Edoardo Cervi, Vincenzo Villanacci, Giancarlo Cervi,
Breast cancer is the most frequent type of tumor and the second leading cause of death in women. Metastases are present in nearly 60% of cases at the time of diagnosis with the lymph nodes, skeleton, lungs, brain and liver as the most frequent sites of metastases. Gastrointestinal involvement is rare, present in only 10% of all the cases. There is a very low risk of developing breast cancer in men.A 68-year-old man, with a past history of ductal breast cancer, presented with duodenal obstruction. ...
Tópico(s): Urinary and Genital Oncology Studies
2009 - BioMed Central | Journal of Medical Case Reports
Antonio Oliva, Simone Grassi, Vincenzo M. Grassi, Vilma Pinchi, Roberto Floris, Guglielmo Manenti, Cesare Colosimo, Laura Filograna, Vincenzo L. Pascali,
Tópico(s): Disaster Response and Management
2021 - Springer Science+Business Media | International Journal of Legal Medicine
Letizia Zeni, Chiara Manenti, Simona Fisogni, Vincenzo Terlizzi, Federica Verzeletti, Mario Gaggiotti, Giovanni Cancarini,
The relationship between kidneys and anticoagulation is complex, especially after introduction of the direct oral anticoagulants (DOAC). It is recently growing evidence of an anticoagulant-related nephropathy (ARN), a form of acute kidney injury caused by excessive anticoagulation. The pathogenesis of kidney damage in this setting is multifactorial, and nowadays, there is no established treatment. We describe a case of ARN, admitted to our Nephrology Unit with a strong suspicion of ANCA-associated ...
Tópico(s): Sarcoidosis and Beryllium Toxicity Research
2020 - Hindawi Publishing Corporation | Case Reports in Nephrology
Marzia Lazzerini, Stefano Martelossi, Giuseppe Magazzù, Salvatore Pellegrino, Maria Cristina Lucanto, A. Barabino, Angela Calvi, Serena Arrigo, Paolo Lionetti, Monica Lorusso, F. Mangiantini, M. Fontana, Giovanna Zuin, Gabriella Palla, Giuseppe Maggiore, Matteo Bramuzzo, Maria Chiara Pellegrin, Massimo Maschio, Vincenzo Villanacci, Stefania Manenti, Giuliana Decorti, Sara De Iudicibus, Rossella Paparazzo, Marcella Montico, Alessandro Ventura,
In a randomized controlled trial, thalidomide has shown to be effective in refractory Crohn's disease in children. This pilot study aimed at evaluating thalidomide in refractory pediatric ulcerative colitis (UC).Double-blind, placebo-controlled randomized clinical trial on thalidomide 1.5 to 2.5 mg/kg/day in children with active UC despite multiple immunosuppressive treatments. In an open-label extension, nonresponders to placebo received thalidomide for an additional 8 weeks; all responders were ...
Tópico(s): Diagnosis and treatment of tuberculosis
2015 - Oxford University Press | Inflammatory Bowel Diseases
Luca Roncati, Giulia Ligabue, Luca Fabbiani, Claudia Malagoli, Graziana Gallo, Beatrice Lusenti, Vincenzo Nasillo, Antonio Manenti, Antonino Maiorana,
Coronavirus Disease 2019 (COVID-19) is an ongoing public health emergency and new knowledge about its immunopathogenic mechanisms is deemed necessary in the attempt to reduce the death burden, globally. For the first time in worldwide literature, we provide scientific evidence that in COVID-19 vasculitis a life-threatening escalation from type 2 T-helper immune response (humoral immunity) to type 3 hypersensitivity (immune complex disease) takes place. The subsequent deposition of immune complexes ...
Tópico(s): Urticaria and Related Conditions
2020 - Elsevier BV | Clinical Immunology
Luca Roncati, Beatrice Lusenti, Vincenzo Nasillo, Antonio Manenti,
Tópico(s): Polyomavirus and related diseases
2020 - Springer Science+Business Media | Annals of Hematology
Marzia Lazzerini, Stefano Martelossi, Giuseppe Magazzù, Salvatore Pellegrino, Maria Cristina Lucanto, A. Barabino, Angela Calvi, Serena Arrigo, Paolo Lionetti, Monica Lorusso, F. Mangiantini, M. Fontana, Giovanna Zuin, Gabriella Palla, Giuseppe Maggiore, Matteo Bramuzzo, Maria Chiara Pellegrin, Massimo Maschio, Vincenzo Villanacci, Stefania Manenti, Giuliana Decorti, Sara De Iudicibus, Rossella Paparazzo, Marcella Montico, Alessandro Ventura,
IMPORTANCE Pediatric-onset Crohn disease is more aggressive than adult-onset disease, has high rates of resistance to existing drugs, and can lead to permanent impairments.Few trials have evaluated new drugs for refractory Crohn disease in children.OBJECTIVE To determine whether thalidomide is effective in inducing remission in refractory pediatric Crohn disease.DESIGN, SETTING, AND PATIENTS Multicenter, double-blind, placebo-controlled, randomized clinical trial of 56 children with active Crohn ...
Tópico(s): Acute Lymphoblastic Leukemia research
2013 - American Medical Association | JAMA
Vincenzo Villanacci, Stefania Manenti, Elisabetta Antonelli, Mariella Chiudinelli, Vittorio Giuliano, Gabrio Bassotti,
Apart from inflammatory bowel diseases (IBD), there are several other form of colitis that may resemble macroscopically IBD, entering the differential diagnosis.These forms are represented by infectious colitis, ischemic colitis, pseudomembranous colitis, colitis related to diverticular disease, colitis related to mucosal prolapse, drug colitis, allergic colitis, and microscopic colitis.However, to distinguish between these forms is not always easy, and it frequently requires a strict interrelationship ...
Tópico(s): Inflammatory Bowel Disease
2011 - Arán Ediciones | Revista Española de Enfermedades Digestivas
Bernard Peissel, Daniela Zaffaroni, Nicola Zanesi, Ignazio Zedda, Giacomo Manenti, Simonetta Rebessi, Simonetta Pazzaglia, Gino Doria, Vincenzo Covelli, Tommaso A. Dragani, Anna Saran,
Tópico(s): Genomics and Chromatin Dynamics
2000 - Springer Science+Business Media | Mammalian Genome
Luca Roncati, Antonio Manenti, Luca Fabbiani, Claudia Malagoli, Vincenzo Nasillo, Beatrice Lusenti, Massimo Lupi, Giuliana Zanelli, Tiziana Salviato, Matteo Costantini, Tommaso Trenti, Antonino Maiorana,
Dear Editor,Coronavirus disease 2019 (COVID-19) is a global public health emergency and new knowledge about it and its etiological agent, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is deemed necessary in order to reduce the death burden around the world [1].In this regard, a 67-yearold Italian male patient, dyslipidemic, hypertensive, active smoker, and a 49-year-old Italian male patient, affected by hypertrophic cardiomyopathy, were admitted to the intensive care unit (ICU) in ...
Tópico(s): Viral gastroenteritis research and epidemiology
2021 - Springer Science+Business Media | Annals of Hematology
Sabina Saccomanno, Stefano Mummolo, Silvia Giancaspro, Rebecca Jewel Manenti, Rodolfo Francesco Mastrapasqua, Giuseppe Marzo, Vincenzo Quinzi,
The present observational prospective study analyzes the eating habits in association with the medico-oral health of catering workers, since they seem the category at higher risk of developing dental problems. Objective: To evaluate oral and medical health through a questionnaire in a total sample of 603 participants. Additionally, this article aims to provide information regarding the medico-oral implications of an unbalanced diet linked to this particular profession. Material and methods: A questionnaire ...
Tópico(s): Oral microbiology and periodontitis research
2021 - Multidisciplinary Digital Publishing Institute | Healthcare
Nicola Bossini, Federico Alberici, Elisa Delbarba, Francesca Valerio, Chiara Manenti, Stefano Possenti, Laura Econimo, Camilla Maffei, Alessandra Pola, Vincenzo Terlizzi, Chiara Salviani, Marianna Moscato, Stefano Pasquali, Nicole Zambetti, Michela Tonoli, Stefania Affatato, Paola Pecchini, F. Viola, Fabio Malberti, G.C. Depetri, Mario Gaggiotti, Francesco Scolari,
The outcome of kidney transplant patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is still unclear. Here we describe the clinical characteristics, disease outcome, and risk factors for acute respiratory distress syndrome (ARDS) and death of a cohort of 53 kidney transplant patients with coronavirus disease 2019 (COVID-19). Eight of 53 have been handled as outpatients because of mild disease, on average with immunosuppression reduction and the addition of hydroxychloroquine ...
Tópico(s): Acute Kidney Injury Research
2020 - Elsevier BV | American Journal of Transplantation
Sandro Accorsi, Nejmudin Kedir, Pasquale Farese, Shallo Dhaba, Vincenzo Racalbuto, Abera Seifu, Fabio Manenti,
This study was aimed at describing disease patterns in a rural zone of Oromiya region, Ethiopia through a retrospective analysis of discharge records for 22,377 inpatients of St. Luke Hospital, Wolisso, Ethiopia in the period 2005-2007. The leading cause of admission was childbirth, followed by injuries, malaria and pneumonia. Injuries were the leading cause of in-hospital deaths, followed by pneumonia, malaria, cardiovascular disease and AIDS. Vulnerable groups (infants, children and women) accounted ...
Tópico(s): Child Nutrition and Water Access
2009 - Oxford University Press | Transactions of the Royal Society of Tropical Medicine and Hygiene
Bernard Peissel, Daniela Zaffaroni, Simonetta Pazzaglia, Giacomo Manenti, Nicola Zanesi, Ignazio Zedda, Simonetta Rebessi, Vincenzo Covelli, Tommaso A. Dragani, Anna Saran,
Tópico(s): Wheat and Barley Genetics and Pathology
2001 - Springer Science+Business Media | Mammalian Genome
Daniele Lecis, Eloise Mastrangelo, Laura Belvisi, Martino Bolognesi, Monica Civera, Federica Cossu, Michelandrea De Cesare, Domenico Delia, Carmelo Drago, Giacomo Manenti, Leonardo Manzoni, Mario Milani, Elisabetta Moroni, Paola Perego, Donatella Potenza, Vincenzo Rizzo, Cinzia Scavullo, Carlo Scolastico, Federica Servida, Francesca Vasile, Pierfausto Seneci,
Novel pro-apoptotic, homodimeric and heterodimeric Smac mimetics/IAPs inhibitors connected through head–head (8), tail–tail (9) or head–tail linkers (10), were biologically and structurally characterized. In vitro characterization (binding to BIR3 and linker-BIR2–BIR3 domains from XIAP and cIAP1, cytotoxicity assays) identified early leads from each dimer family. Computational models and structural studies (crystallography, NMR, gel filtration) partially rationalized the observed properties for each ...
Tópico(s): RNA Interference and Gene Delivery
2012 - Elsevier BV | Bioorganic & Medicinal Chemistry
Vincenzo Quinzi, Sabina Saccomanno, Rebecca Jewel Manenti, Silvia Giancaspro, Licia Coceani Paskay, Giuseppe Marzo,
Aim: To systematically review international literature related to rapid maxillary expansion (RME) as the treatment for obstructive sleep apnea syndrome (OSAS) in children less than 18 years-old, followed by a meta-analysis of the apnea-hypopnea index (AHI) before and after RME, with or without a previous adenotonsillectomy (AT). Methods: Literature on databases from PubMed, Wiley online library, Cochrane Clinical Trials Register, Springer link, and Science Direct were analyzed up to March 2020. Two ...
Tópico(s): Cardiovascular and Diving-Related Complications
2020 - Multidisciplinary Digital Publishing Institute | Applied Sciences
Vincenzo Quinzi, Licia Coceani Paskay, Rebecca Jewel Manenti, Silvia Giancaspro, Giuseppe Marzo, Sabina Saccomanno,
Background: Orofacial pain has a broad range of origins and a multidisciplinary approach occupies a relevant role. Objective: The aim of this study was to review the literature regarding the evolution of telemedicine and orofacial pain related to a case report of a patient affected by Eagle's syndrome. Materials and Methods: Two authors (RJM and SG) independently reviewed the literature up to March 2020. A case report was developed by including the interdisciplinary assessment and initial treatment ...
Tópico(s): Oropharyngeal Anatomy and Pathologies
2021 - Bentham Science Publishers | The Open Dentistry Journal
Luca Reggiani Bonetti, Giuseppe Leoncini, Marco Daperno, Mariabeatrice Principi, Carla Baronchelli, Stefania Manenti, Flavio Caprioli, Alessandro Armuzzi, Alessandro Caputo, Paola Parente, Moris Cadei, Vincenzo Villanacci,
Pathologists are often called upon to diagnose colitides that differ from the two main forms of inflammatory bowel disease (IBD). These non-IBD colitides include infectious colitis, microscopic colitis, ischemic colitis, eosinophilic colitis, autoimmune enterocolitis, segmental colitis associated with diverticulosis, drug-induced colitis, radiation colitis and diversion colitis. The diagnosis of these different disease entities relies on the histopathological examination of endoscopic biopsies of ...
Tópico(s): Inflammatory Bowel Disease
2021 - Elsevier BV | Digestive and Liver Disease
Vincenzo Trotta, Cino Pertoldi, Andrey Rudoy, Tommaso Manenti, Sandro Cavicchi, Davide Guerra,
CR Climate Research Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout the JournalEditorsSpecials CR 43:71-79 (2010) - DOI: https://doi.org/10.3354/cr00880 Thermal plasticity of wing size and shape in Drosophila melanogaster, D. simulans and their hybrids V. Trotta1,*, C. Pertoldi2,3, A. Rudoy1, T. Manenti1, S. Cavicchi1, D. Guerra1 1Alma Mater Studiorum, Università di Bologna, Dipartimento di Biologia Evoluzionistica Sperimentale, ...
Tópico(s): Animal Behavior and Reproduction
2010 - Inter-Research Science Center | Climate Research
Alberto Ravelli, Vincenzo Villanacci, S Chiappa, S. Bolognini, Stefania Manenti, Maurizio Fuoti,
Cow's milk protein-induced proctocolitis presents with overt rectal bleeding in otherwise healthy infants and is characterized by an eosinophilic infiltrate of the left colonic mucosa. Although it is the most common cause of proctocolitis in infancy, dietary protein-induced proctocolitis had hardly ever been reported in childhood so far. We hereby report 16 otherwise healthy children aged 2-14 yr, who presented over a 6-yr period with persistent or recurrent rectal bleeding related to a mild form ...
Tópico(s): Gastrointestinal disorders and treatments
2008 - Lippincott Williams & Wilkins | The American Journal of Gastroenterology
Gabrio Bassotti, Vincenzo Villanacci, Riccardo Nascimbeni, Moris Cadei, Stefania Manenti, Elisabetta Antonelli, Lucia Fanini, Bruno Salerni,
Tópico(s): Pelvic floor disorders treatments
2011 - Springer Science+Business Media | Digestive Diseases and Sciences
Gabrio Bassotti, Vincenzo Villanacci, Riccardo Nascimbeni, Moris Cadei, S. Manenti, Giuseppe Sabatino, Christoph A. Maurer, Gieri Cathomas, Bruno Salerni,
Abstract Aliment Pharmacol Ther 2011; 34: 92–99 Summary Background There is recent evidence that mast cells may play important roles in the gut, especially concerning visceral hypersensitivity and motor activity. However, most data are only available for clinical conditions characterised by diarrhoea, where MC have chiefly investigated in the mucosal layer of the colon and there is almost no information concerning constipation. Aim To investigate mast cells distribution in all colonic layers in ...
Tópico(s): Mast cells and histamine
2011 - Wiley | Alimentary Pharmacology & Therapeutics
Ilaria Varotto-Boccazzi, Micaela Garziano, Giulia Maria Cattaneo, Beatrice Bisaglia, Paolo Gabrieli, Mara Biasin, Alessandro Manenti, Diego Rubolini, Mario Clerici, Emanuele Montomoli, Gian Vincenzo Zuccotti, Daria Trabattoni, Sara Epis, Claudio Bandi,
Protozoa of the genus Leishmania are characterized by their capacity to target macrophages and Dendritic Cells (DCs). These microorganisms could thus be exploited for the delivery of antigens to immune cells. Leishmania tarentolae is regarded as a non-pathogenic species; it was previously used as a biofactory for protein production and has been considered as a candidate vaccine or as an antigen delivery platform. However, results on the type of immune polarization determined by L. tarentolae are ...
Tópico(s): Viral Infections and Outbreaks Research
2022 - Multidisciplinary Digital Publishing Institute | Vaccines
Vincenzo Quinzi, Alessandro Polizzi, Vincenzo Ronsivalle, Simona Santonocito, Cristina Conforte, Rebecca Jewel Manenti, Gaetano Isola, Antonino Lo Giudice,
The aim of the study was to systematically review and compare the accuracy of smartphone scanners versus stereophotogrammetry technology for facial digitization in children. A systematic literature search strategy of articles published from 1 January 2010 to 30 August 2022 was adopted through a combination of Mesh terms and free text words pooled through boolean operators on the following databases: PubMed, Scopus, Web of Science, Cochrane Library, LILACS, and OpenGrey. Twenty-three articles met ...
Tópico(s): Facial Rejuvenation and Surgery Techniques
2022 - Multidisciplinary Digital Publishing Institute | Children
Federico Alberici, Elisa Delbarba, Chiara Manenti, Laura Econimo, Francesca Valerio, Alessandra Pola, Camilla Maffei, Stefano Possenti, Bernardo Lucca, R Cortinovis, Vincenzo Terlizzi, Mattia Zappa, Chiara Saccà, Elena Pezzini, Eleonora Calcaterra, Paola Piarulli, Alice Guerini, Francesca Boni, Agnese Gallico, Alberto Mucchetti, Stefania Affatato, Sergio Bove, Martina Bracchi, Ester Maria Costantino, Roberto Zubani, Corrado Camerini, Paola Gaggia, Ezio Movilli, Nicola Bossini, Mario Gaggiotti, Francesco Scolari,
The SARS-CoV-2 epidemic is pressuring healthcare systems worldwide. Disease outcomes in certain subgroups of patients are still scarce, and data are needed. Therefore, we describe here the experience of four dialysis centers of the Brescia Renal COVID Task Force. During March 2020, within an overall population of 643 hemodialysis patients, SARS-CoV-2 RNA positivity was detected in 94 (15%). At disease diagnosis, 37 of the 94 (39%) patients (group 1) were managed on an outpatient basis, whereas the ...
Tópico(s): Sepsis Diagnosis and Treatment
2020 - Elsevier BV | Kidney International