Summary Viremia with JE virus and its relationship to pathogenicity were studied in mice. The degree of viremia and susceptibility to peripheral infection decreased with age. ... between 1 and 2 weeks of age. A viremia-positive (V+) variant was isolated by rapid blood- ... week-old mice. This strain causes the highest viremia with JE virus ever reported in 3-week- ... when 30 PFU were inoculated subcutaneously. In general, viremia with JE virus was not detected so easily ... was a proportional relationship between the occurrence of viremia and pathogenicity. The V+ variant showed 100-fold ...
Tópico(s): Plant Virus Research Studies
1969 - American Association of Immunologists | The Journal of Immunology
H. G. duBuy, M. Worthington, M. L. Johnson,
... the degree of chronic lactic dehydrogenase virus (LDV) viremia in mice. Weekly injections of cyclophosphamide caused an increase of LDV viremia of ca. 2.5 log 10 50% infectious doses per ml as compared to the viremia in the nontreated mice. This increase occurred at ... administration and was accompanied by a decrease in viremia. The normal decrease of early viremia during the first 2 weeks of infection in ... the cause of this initial decrease in LDV viremia but that interferon and perhaps other nonimmune factors ...
Tópico(s): Herpesvirus Infections and Treatments
1971 - American Society for Microbiology | Infection and Immunity
Turkey herpesvirus (HVT) viremia was studied at 3-week intervals through 21 weeks of age in individual chickens of experimental (WSU-VS) and ... Leghorns vaccinated with graded doses of HVT. HVT viremia was consistently detectable in all WSU-VS birds ... PV) regardless of vaccine dose employed, whereas the viremia could not be detected in some of the ... and thereafter. C-WL birds that lost detectable viremia remained so up to 21 weeks PV, or returned to low levels of viremia which was followed in some birds again by ...
Tópico(s): Animal Disease Management and Epidemiology
1977 - American Association of Avian Pathologists | Avian Diseases
The development and persistence of viremia were followed in two lines of Single-Comb White Leghorns: one experimental line (WSU-VS) highly susceptible, and one commercial line ( ... disease(MD). In the resistant C-WL chicken, viremia with a mild strain of MD herpesvirus (MDHV) ... viremic birds through 8 weeks postinoculation (PI), while viremia with an acute strain of MDHV did not, ... weeks PI. In the susceptible WSU-VS chicken, viremia with acute MDHV persisted in all viremic birds whereas viremia with mild MDHV was detected in a decreasing ...
Tópico(s): Yersinia bacterium, plague, ectoparasites research
1975 - American Association of Avian Pathologists | Avian Diseases
Frederick Cox, Walter T. Hughes,
... saliva in order to determine the relationship of viremia to clinical cytomegalic inclusion disease. Eleven of 36 (30.5%) patients had viremia. Viremia was related to clinical disease in only three ... a CMV mononucleosis syndrome. However, the presence of viremia did not serve as a useful means to ... serum levels of IgM and multiple episodes of viremia. Viremia was not related to the duration, type or ... titer, and viruria had no consistent relationship to viremia or clinical CID. Leukocyte and urine cultures were ...
Tópico(s): Parvovirus B19 Infection Studies
1975 - Elsevier BV | The Journal of Pediatrics
Brigitte P. Griffith, M Chen, Harriet C. Isom,
... intrauterine guinea pig cytomegalovirus (GPCMV) infection by maternal viremia was investigated in the guinea pig model. Virus ... was most efficient in mothers inoculated subcutaneously. Primary viremia was followed by virus clearance from blood and by an episode of secondary viremia in the three groups of mothers examined. Placental ... were first detected at the time of primary viremia, persisted throughout gestation, and increased during secondary viremia. In contrast, placental and fetal infections in animals ...
Tópico(s): Diabetes and associated disorders
1990 - American Society for Microbiology | Journal of Virology
Yeon Seok Seo, Eun Suk Jung, Jeong Han Kim, Young Kul Jung, Ji Hoon Kim, Hyonggin An, Hyung Joon Yim, Jong Eun Yeon, Kwan Soo Byun, Chang Duck Kim, Ho Sang Ryu, Soon Ho Um,
... enzyme immunoassay were enrolled. Patients were divided into viremia and no-viremia groups according to HCV RNA results. Receiver-operating ... anti-HCV S/CO for a diagnosis of viremia. Results In total, 487 patients were enrolled. HCV ... S/CO ratio were significantly different between the viremia and no-viremia groups. By ROC curve analysis, anti-HCV S/ ... to 0.998) accurately predicted the presence of viremia, with a cutoff value of 10.9 (sensitivity, ... found to be highly accurate at predicting HCV viremia. The anti-HCV S/CO ratio can be ...
Tópico(s): Hepatitis B Virus Studies
2009 - Korean Association of Internal Medicine | The Korean Journal of Internal Medicine
Hans H. Hirsch, Parmjeet Randhawa,
... patients with high-level viruria progress to BKV viremia and histologically and clinically manifest PyVAN (3, 50- ... BKV loads >7 log geq/mL and BKV viremia (3, 53). Other markers associated with PyVAN are ... suspicion, for example in cases with sustained BKV viremia and a negative initial biopsy ('presumptive PyVAN'). The ... with PyVAN, who was nonetheless able to clear viremia in due course of time (96). Approximately 5– ... frequent scenario is the recurrence of viruria or viremia with interstitial inflammation, and tubulitis, but no viral ...
Tópico(s): Full-Duplex Wireless Communications
2009 - Elsevier BV | American Journal of Transplantation
Claire Dunn, Dimitra Peppa, Pooja Khanna, Gaia Nebbia, Meleri Jones, Nathan J. Brendish, R. Monica Lascar, David J. Brown, Richard Gilson, Richard S. Tedder, Geoffrey Dusheiko, Michael Jacobs, Paul Klenerman, Mala K. Maini,
... study; by the time most patients present, massive viremia and the majority of viral clearance have already ... 8 of them from before the peak of viremia. Circulating innate cytokines were quantitated by enzyme-linked ... and IFN-λ1 were not induced during peak viremia. NK cell activation and capacity for IFN-γ production were reduced at peak viremia. Early functional HBV-specific CD4 and CD8 T- ... in the immunosuppressive cytokine interleukin-10 accompanying HBV viremia.ConclusionsThe early stages of acute HBV are characterized ...
Tópico(s): Liver Disease Diagnosis and Treatment
2009 - Elsevier BV | Gastroenterology
Jason Grebely, David L. Thomas, Gregory J. Dore,
... will have a persistent infection marked by ongoing viremia. This outcome is determined by a partially understood ... rechallenge, reductions in the duration and magnitude of viremia when compared to the initial infection have also ... CD8+ T cell depletion led to prolonged HCV viremia, which was only controlled once CD8+ T cells ... has been observed in chimpanzees, levels of HCV viremia following reinfection are lower, generally transient, and shorter ... ve HCV infection is associated with diminished secondary viremia and generation of new cellular immune responses during ...
Tópico(s): Hepatitis B Virus Studies
2009 - Elsevier BV | Journal of Hepatology
Leonardo Potenza, Patrizia Barozzi, Michele Masetti, Monica Pecorari, Pablo Diego Bresciani, Agnès Gautheret‐Dejean, Giovanni Riva, Daniela Vallerini, Sara Tagliazucchi, Mauro Codeluppi, Fabrizio Di Benedetto, Giorgio Enrico Gerunda, Franco Narni, Giuseppe Torelli, Mario Luppi,
... be excluded in transplant patients with HHV-6 viremia by the comparison of HHV-6 loads on ... be excluded in transplant patients with HHV-6 viremia by the comparison of HHV-6 loads on ... follow-up period, 292 episodes of HHV-6 viremia (218 in SOT and 74 in SCT setting, ... out of 16 SCT patients with HHV-6 viremia presented CMV coinfection. Patients with concomitant HHV-6 and CMV viremia presented neither higher values of CMV antigenemia nor ... either in SOT or SCT patients with CMV viremia and their clinical outcome are consistent with those ...
Tópico(s): Polyomavirus and related diseases
2009 - Elsevier BV | American Journal of Transplantation
Peter H. O’Donnell, Kate Swanson, Michelle A. Josephson, Andrew Artz, Sandeep Parsad, Charulata Ramaprasad, Kenneth Pursell, Elizabeth Rich, Wendy Stock, Koen van Besien,
... 64.8% of the patients; 16.9% developed viremia. In the prospective cohort, the median time from transplantation to BK viremia development (128 days) was longer than for viruria ( ... sex, disease, transplant type, alemtuzumab use, cytomegalovirus [CMV] viremia, graft-versus-host disease [GVHD], donor HLA C7 allele), only CMV viremia was more common in patients with BKV infection ( ... HSCT renal impairment. On multivariate analysis, only BK viremia (P=.000002) and alternative-donor transplantation (P=.002) ... development of post-HSCT renal impairment, with BK viremia associated with a median 1.62 mg/dL ...
Tópico(s): Polyomavirus and related diseases
2009 - Elsevier BV | Biology of Blood and Marrow Transplantation
Michelle A. Barron, Dexiang Gao, Kathryn L. Springer, Julie A. Patterson, Mark W. Brunvand, Peter A. McSweeney, Zeng Chang, Anna E. Barón, Adriana Weinberg,
... Twenty-one subjects developed ⩾1 episode of CMV viremia and 4 developed disease during 360 days of ... before transplantation correlated with higher risk of developing viremia after transplantation (P=.02). In contrast, after transplantation, ... LPA was significantly associated with absence of CMV viremia over 360 days of follow-up (P=.04) and with faster clearance of viremia during individual episodes of CMV reactivation (P=.03). ... cells was also associated with absence of CMV viremia over 360 days of study (P=.04) but ...
Tópico(s): Toxoplasma gondii Research Studies
2009 - Oxford University Press | Clinical Infectious Diseases
Anders Widell, Michael P. Busch,
... and incident infections with high levels of acute viremia, thereby interdicting donations given during the late ramp- ... clearance of HCV infection with true eradication of viremia, which occurs in 30% to 50% of infections, ... Both spontaneous and treatment-induced clearance of HCV viremia is followed by a waning of humoral immune ... signs of conventional antibody responses to HCV or viremia. Several recent studies support this finding. In a ... active IDUs with anti-HCV but without HCV viremia have the highest rates (94%) and broadest T- ...
Tópico(s): Liver Disease Diagnosis and Treatment
2009 - Wiley | Transfusion
Steven G. Deeks, Bernard Hirschel,
... to continue combination therapy indefinitely as long as viremia remains undetectable [1–3]. Most treatment naïve patients ... regimens achieve and maintain undetectable levels of plasma viremia. As a result, CD4+ T cell counts increase ... load ‘set-point’) [13,14]. This reduction of viremia is temporally associated with the emergence of an ... found in untreated patients who maintain low-level viremia for years (‘long-term non-progressors’) but not ... T cells are depleted in SIV infected monkeys, viremia increases. As CD8+ T cells reaccumulate, viremia decreases [ ...
Tópico(s): HIV/AIDS drug development and treatment
2002 - Lippincott Williams & Wilkins | AIDS
Peter Sklar, Douglas Ward, Rose Baker, Kathleen C. Wood, Zarina Gafoor, Carlos Alzola, Anne C. Moorman, Scott D. Holmberg,
... the prevalence and clinical correlates of subsequently measurable viremia in HIV-infected patients who have achieved viral ... viremic patients were defined having a subsequently measurable viremia but again achieved suppression < 50 copies/ml. Results: ... the 448 patients, 122 (27.2%) had transient viremia, 19 (4.2%) had lasting low-level viremia and 33 (7.4%) had lasting high-level viremia (defined as 50–400 and > 400 copies/ml, ... 16 (13.1%) of those who had transient viremia later had persistent viremia > 50 copies/ml. The ...
Tópico(s): HIV/AIDS drug development and treatment
2002 - Lippincott Williams & Wilkins | AIDS
Nina Singh, Shahid Husain, Donald R. Carrigan, Konstance Knox, Karen E. Weck, Marilyn M. Wagener, Timothy Gayowski,
... including TNF‐α. The impact of HHV‐6 viremia on the progression of recurrent HCV hepatitis was ... hepatitis did not differ between patients with HCV viremia (47.6%, 10/21) as compared with those without HCV viremia (46.7%, 14/30, p=0.9). However, the patients with HHV‐6 viremia had a significantly higher fibrosis score upon HCV recurrence than those without HHV‐6 viremia (mean 1.5 vs. 0.3, p=0.01). An association between cytomegalovirus (CMV) viremia and HCV recurrence was not documented; 50% (15/30) of the patients with CMV viremia and 42.8% (9/21) of those without ...
Tópico(s): Herpesvirus Infections and Treatments
2002 - Wiley | Clinical Transplantation
S. Magrin, Antonio Craxı̀, Carmelo Fabiano, Rosa G Simonetti, G Fiorentino, L Marino, Orazia Diquattro, V. Di Marco, Oreste Loiacono, Riccardo Volpes, Piero Luigi Almasio, Mickey S. Urdea, Paul Neuwald, Ray Sánchez-Pescador, Jill Detmer, Judith C. Wilber, Luigi Pagliaro,
We assessed the pattern of hepatitis C viremia in chronic liver disease by studying 100 hepatitis C virus antibody-positive patients: 48 with chronic hepatitis, 21 with cirrhosis and 31 with ... based on branched DNA that can also quantify viremia. Hepatitis C virus RNA was found in 94 ... patients with branched-DNA (p < 0.001). Mean viremia level (× 10 3 genome equivalents/ml ± S.D.), ... 02). We also analyzed retrospectively the relationship between viremia and treatment. Fifty-five patients (41 chronic hepatitis, ...
Tópico(s): Hepatitis B Virus Studies
1994 - Lippincott Williams & Wilkins | Hepatology
We assessed the pattern of hepatitis C viremia in chronic liver disease by studying 100 hepatitis C virus antibody–positive patients: 48 with chronic hepatitis, 21 with cirrhosis and 31 with ... based on branched DNA that can also quantify viremia. Hepatitis C virus RNA was found in 94 ... patients with branched-DNA (p < 0.001). Mean viremia level (× 103 genome equivalents/ml ± S.D.), as ... 02). We also analyzed retrospectively the relationship between viremia and treatment. Fifty-five patients (41 chronic hepatitis, ...
Tópico(s): Systemic Lupus Erythematosus Research
1994 - Lippincott Williams & Wilkins | Hepatology
Frank Mattes, Anita Vargas, J Kopycinski, Emma Hainsworth, P. Sweny, Gaia Nebbia, A. Bazeos, Mark W. Lowdell, Paul Klenerman, Rodney E. Phillips, P. D. Griffiths, Vincent C. Emery,
... study, high-level replication (henceforth referred to as viremia) was defined as viral loads above 200 genomes/ ... according to whether patients experienced high level replication (viremia >200 genomes/ mL blood) with a sub-stratification ... Samples from patients who did not experience HCMV viremia ( 200 genomes/mL blood) and were given pre- ... to determine factors associated with appearance of HCMV viremia. A more comprehensive summary of patient demographics is ... the donor/recipient HCMV serostatus and incidence of viremia in the 10 patients excluded from the study ( ...
Tópico(s): Renal Transplantation Outcomes and Treatments
2008 - Elsevier BV | American Journal of Transplantation
... reducing the rate of infection or reducing chronic viremia after infection – should the CTL-based approach be ... primary infection because the ensuing ‘set-point’ of viremia is highly predictive of disease progression rate; thus, ... and at least temporarily boost immune control of viremia [46,47]. Assessing the impact of CTL escape ... substantially between early (pre-establishment of set-point viremia) and chronic infection (quasi-steady state viremia during the asymptomatic phase) [48–50]. This finding ... stability during chronic infection, reflected by set-point viremia [18,35]. Accordingly, escape mutations occur in many ...
Tópico(s): Cytomegalovirus and herpesvirus research
2008 - Lippincott Williams & Wilkins | AIDS
E. Renoult, François Coutlée, M Pâquet, GILLE ST. LOUIS, Catherine Girardin, Marie‐Chantal Fortin, Héloïse Cardinal, Renée Lévesque, Walter Schürch, Mathieu Latour, Azemi Barama, Marie‐Josée Hébert,
... 1 year, seven (7%) patients displayed sustained BK viremia at a median of 92 days after transplantation. ... stable renal function. BKPVAN was preceded by asymptomatic viremia except for two cases in whom BK viremia occurred at 6 or 11 months, after the ... At 12 months, six patients had cleared their viremia. Serum creatinine levels had stabilized in six recipients ... 7 ± 16.3 mL/min in patients with viremia and/or BKPVAN versus 61.3 ± 20.1 ... viremic (P = .03). None of the patients with viremia and/or BKPVAN lost the allograft. BKPVAN may ...
Tópico(s): Antenna Design and Analysis
2010 - Elsevier BV | Transplantation Proceedings
Stefan Schaub, Hans H. Hirsch, Michael Dickenmann, Jürg Steiger, Michael J. Mihatsch, Helmut Hopfer, Michael Mayr,
Early detection of polyomavirus BK (BKV) viremia and reduction of immunosuppression is recommended for preventing polyomavirus-associated nephropathy (Py-VAN), but systematic histological evaluations were not performed in previous ... from 2005–2008, 38 patients (19%) developed BKV-viremia and were treated with reduction of immunosuppression. Based on subsequent allograft biopsy results and peak BKV-viremia, patients were assigned to three groups: (i) definitive ... copies/ml (n = 17) and (iii) low BKV-viremia (n = 8). Clearance of BKV-viremia was achieved ...
Tópico(s): Energy Harvesting in Wireless Networks
2010 - Elsevier BV | American Journal of Transplantation
A. Thompson, Stephen Locarnini, Kumar Visvanathan,
... intrahepatic hepatitis B virus productivity contributes to low viremia in most HBeAg-negative patients” by Volz T, ... intrahepatic hepatitis B virus productivity contributes to low viremia in most HBeAg-negative patients.Gastroenterology. 2007; 133: ... intrahepatic hepatitis B virus productivity contributes to low viremia in most HBeAg-negative patients.Gastroenterology. 2007; 133: ... intrahepatic hepatitis B virus productivity contributes to low viremia in most HBeAg-negative patients.Gastroenterology. 2007; 133: ...
Tópico(s): Hepatitis Viruses Studies and Epidemiology
2007 - Elsevier BV | Gastroenterology
... resistant to heat inactivation, and caused a transient viremia. Concerns about this viremic stage were abrogated by ... spread and is highest at the time of viremia, before the onset of rash or arthralgia. It ... healthy individuals at the height of the transient viremia viral titers as high as 1014 IU per ... normally performed. The frequent occurrence of low-level viremia of B19V and the lack of blood component ... transmissions resulting from the observed frequency of B19V viremia of approximately 1 percent in donors might be ...
Tópico(s): Dermatological and COVID-19 studies
2007 - Wiley | Transfusion
Yen–Hsuan Ni, Mei‐Hwei Chang, Pei‐Jer Chen, Keh–Sung Tsai, Hong‐Yuan Hsu, Huey‐Ling Chen, Daw‐Jen Tsuei, Ding‐Shinn Chen,
Background & Aims: This study investigated the viremia profiles in children with chronic hepatitis B virus (HBV) infection and spontaneous hepatitis B e antigen (HBeAg) seroconversion. Methods: Fifty-eight children ... post-HBeAg seroconversion HBV-DNA levels: (1) low viremia: transient or never 104 copies/mL or greater (n = 35) (2) fluctuating high viremia: 104 copies/mL or greater at least twice ... mutant appeared more often in the fluctuating-high-viremia group than in the low-viremia group (60.9% vs 22.9%, P = .004). ...
Tópico(s): Hepatitis Viruses Studies and Epidemiology
2007 - Elsevier BV | Gastroenterology
Jason T. Blackard, Mohamed Tarek M. Shata, Norah J. Shire, Kenneth E. Sherman,
... acute infection will develop chronic disease,8 persistent viremia occurring at least 6 months after initial exposure, ... viral diversity in 5 individuals who spontaneously cleared viremia and 10 individuals with persistent viremia. Persistent viremia was associated with a higher hypervariable region 1 ( ... Spontaneous clearers also differed from individuals with persistent viremia at 8 amino acid positions, although no residues ... of neutralizing anti-HCV antibodies and clearance of viremia has been reported.56 In fact, there exists ...
Tópico(s): Hepatitis B Virus Studies
2007 - Lippincott Williams & Wilkins | Hepatology
Wang‐Huei Sheng, Chien‐Ching Hung, R.-J. Wu, Jann‐Tay Wang, Pei‐Jer Chen, Shan‐Chwen Chang, Jia‐Horng Kao,
The influence of GB virus C (GBV-C) viremia on clinical outcomes of patients with human immunodeficiency ... conducted to describe the epidemiology of GBV-C viremia and assess its clinical impact on treatment responses ... patients (15.3%) had detectable GBV-C RNA viremia during a median observation of 3.6 years ( ... years); 47 patients (12.2%) had GBV-C viremia at enrollment, and 12 (3.1%) acquired GBV- ... of the 47 patients with baseline GBV-C viremia had persistent GBV-C viremia. Compared with patients with clearance of GBV-C ...
Tópico(s): HIV Research and Treatment
2007 - Oxford University Press | Clinical Infectious Diseases
Dechu Puliyanda, Mieko Toyoda, Avram Z. Traum, Francisco X. Flores, Stanley C. Jordan, Asha Moudgil, Michaël Somers,
... groups; Group 1: Viruria only (6), Group 2: Viremia with stable GFR (4), Group 3: Viremia with >25% decline in GFR and BKVAN on ... patients; GFR remained stable. Group 2 showed reduced viremia with no GFR change. Group 3 showed reduced viremia in 8/8 patients. Patients with >50% decline ... with viruria alone no treatment is necessary; with viremia and stable GFR, reduced immunosuppression decreases viremia and maintains GFR. With viremia and reduced GFR, immunosuppression reduction with or without cidofovir decreases viremia and stabilizes GFR in most patients. Greater than ...
Tópico(s): Parvovirus B19 Infection Studies
2007 - Wiley | Pediatric Transplantation
Robert M. Cannon, Guy Brock, Michael R. Marvin, M Eng, Joseph F. Buell,
... at a single center. The incidence of BK viremia was determined, and univariate analysis was performed to determine factors associated with the development of BK viremia. Further analysis was undertaken, using standard statistical methods, ... for AR in patients with and without BK viremia.There were 456 patients in the current study, ... 5% were Caucasian. The overall incidence of BK viremia identified on routine screening was 6.6%. Univariate ... failed to identify any significant predictors of BK viremia. One-, 3-, and 5-year graft survival for ...
Tópico(s): Organ and Tissue Transplantation Research
2011 - Wiley | Transplant Infectious Disease