Anna Laura Iamiceli, Alessandro Ubaldi, Dario Lucchetti, Gianfranco Brambilla, Vittorio Abate, Elena De Felip, Stefania Paola De Filippis, Elena Dellatte, Silvia De Luca, Fabiola Ferri, Igor Fochi, Anna Rita Fulgenzi, Nicola Iacovella, Ivo Moret, Rossano Piazza, Alessandra Roncarati, Paolo Melotti, Roberto Fanelli, Elena Fattore, Alessandro Di Domenico, Roberto Miniero,
Metals such as arsenic (As), cadmium (Cd), copper (Cu), chromium (Cr), nickel (Ni), lead (Pb), vanadium (V), have been determined in species of Mediterranean marine organisms collected from areas supposed to be at background contamination levels. The Inductively Coupled Plasma Mass Spectrometry (ICP-MS) approach was adopted for the determination of all the metals. Arsenic, Cd and Pb determined in the 42 samples, do not exceed the pertinent maximum level except a sample of hake. In wild fish, the concentration ...
Tópico(s): Mercury impact and mitigation studies
2015 - Elsevier BV | Marine Pollution Bulletin
Gianfranco Brambilla, Vittorio Abate, G. Battacone, Stefania Paola De Filippis, Mauro Esposito, Vittorio Esposito, Roberto Miniero,
The organic carbon of biosolids from civil wastewater treatment plants binds persistent organic pollutants (POPs), such as polychlorodibenzo -dioxins and -furans (PCDD/Fs), dioxin and non-dioxin -like polychlorobiphenyls (DL and NDL-PCBs), polybrominated diphenyl ethers (PBDEs), and perfluorooctane sulfonic acid (PFOS). The use of such biosolids, derived digestates and composts as top soil improvers (TSIs) may transfer POPs into the food chain. We evaluated the potential carry-over of main bioavailable congeners ...
Tópico(s): Effects and risks of endocrine disrupting chemicals
2015 - Elsevier BV | The Science of The Total Environment
Giovanni Mauri, Luca Maria Sconfienza, B. Fiore, G. Brambilla, Vittorio Pedicini, Dario Poretti, Romano Fabio Lutman, Marco Montorsi, Francesco Sardanelli,
Enteric fistulae represent a serious complication of abdominal surgery, associated with increased hospital stay and high postoperative morbidity and mortality. 1 Falconi M. Pederzoli P. The relevance of gastrointestinal fistulae in clinical practice: a review. Gut. 2001; 49: 2-10 PubMed Google Scholar , 2 Schecter W.P. Hirshberg A. Chang D.S. et al. Enteric fistulas: principles of management. J Am Coll Surg. 2009; 209: 484-491 Abstract Full Text Full Text PDF PubMed Scopus (143) Google Scholar Moreover, ...
Tópico(s): Diverticular Disease and Complications
2012 - Elsevier BV | Clinical Radiology
Gianfranco Brambilla, Vittorio Abate, Stefania Paola De Filippis, Anna Rita Fulgenzi, Anna Laura Iamiceli, A. Mazzette, Roberto Miniero, Giuseppe Pulina,
An observational study was set up to evaluate how the quality of the environment may influence the levels of of PCDDs, PCDFs, and DL-PCBs in sheep's milk. Seven farms under natural and anthropogenic pressures were considered, along with an inventory of the surrounding regular and natural sources of emissions. Analysis by HRGC-HRMS revealed the highest cumulative levels (2.1 pg of WHO(1998)-TE/g fat) in one organic and one conventional farm, each close to a relevant bushfire. Their pattern was characterized ...
Tópico(s): Air Quality and Health Impacts
2011 - American Chemical Society | Journal of Agricultural and Food Chemistry
Gianfranco Brambilla, Vittorio Abate, Alessandro Di Domenico, Mauro Esposito, Anna Rita Fulgenzi, Nicola Iacovella, Francesco Paolo Serpe, Marco Tassinari,
Maize (Zea mays L.) can intercept airborne pollutants before their deposition on soil. Selected non-dioxin-like polychlorinated biphenyls (Σ6NDL-PCBs) and polybrominated diphenyl ethers (Σ8PBDEs) with feed and food safety relevance were measured on maize leaves harvested for silage in dairy animals from 28 fields in Italy. Analyses were carried out by gas chromatography coupled to high- and low-resolution mass spectrometry. Contamination ranged from 0.65 to 5.3 ng g(-1) with 12% moisture for Σ6NDL- ...
Tópico(s): Effects and risks of endocrine disrupting chemicals
2015 - Taylor & Francis | Food Additives & Contaminants Part A
Seong Cheng Dong, Manuele Bicego, Umberto Castellani, Stefania Cerutti, Marcella Bellani, Gianluca Rambaldelli, Manfredo Atzori, Paolo Brambilla, Vittorio Murino,
Is it possible to identify human schizophrenic patients just by analyzing their brain images? This is the fundamental question of magnetic resonance imaging (MRI) based studies of human brains for people affected by schizophrenia and other mental illnesses traditionally diagnosed by self-reports and behavioral observations. The appeal of this approach is at least two-fold: to provide a non-invasive diagnostic tool for mass analyses and early diagnoses, and to characterize mental illnesses with specific ...
Tópico(s): Schizophrenia research and treatment
2009 - IOS Press | Intelligent Data Analysis
Paolo Mocarelli, Pier Mario Gerthoux, Donald G. Patterson, Silvano Milani, Giuseppe Limonta, Maria Bertona, Stefano Signorini, Pierluigi Tramacére, Laura Colombo, Carla Crespi, Paolo Brambilla, Cecilia Sarto, Vittorio Carreri, Eric J. Sampson, Wayman E. Turner, Larry L. Needham,
BackgroundEnvironmental toxicants are allegedly involved in decreasing semen quality in recent decades; however, definitive proof is not yet available. In 1976 an accident exposed residents in Seveso, Italy, to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).ObjectiveThe purpose of this study was to investigate reproductive hormones and sperm quality in exposed males.MethodsWe studied 135 males exposed to TCDD at three age groups, infancy/prepuberty (1–9 years), puberty (10–17 years), and adulthood (18–26 ...
Tópico(s): Reproductive Biology and Fertility
2008 - National Institute of Environmental Health Sciences | Environmental Health Perspectives
Luigi Brambilla, Luciano Colombo, Vittorio Rosato, Fabrizio Cleri,
We studied the microscopic kinetics of the amorphous-liquid interface in supercooled laser-melt silicon by means of molecular dynamics computer simulations. The interface velocity was obtained as a function of temperature by direct simulation of the interface motion in an amorphous-liquid model system. The temperature dependence of the kinetic prefactor was extracted from the interface velocity function and compared to the values of self-diffusivity obtained from independent molecular dynamics simulations ...
Tópico(s): Metallic Glasses and Amorphous Alloys
2000 - American Institute of Physics | Applied Physics Letters
Andrea Giordano, Alessandra Lugaresi, Paolo Confalonieri, Franco Granella, D. Radice, Maria Trojano, Vittorio Martinelli, Alessandra Solari, Andrea Giordano, Vittorio Martinelli, Alessandra Lugaresi, Eugenio Pucci, Franco Granella, Maria Trojano, Alessandra Solari, Vittorio Martinelli, Eugenio Pucci, Michele Messmer Uccelli, Alessandra Lugaresi, Andrea Giordano, Franco Granella, Alessandra Solari, Andrea Giordano, Giulia Ferrari, Fernanda Martini, Alessandra Solari, D. Radice, Giuseppe d’Annunzio, Alessandra Lugaresi, D. Farina, D. Travaglini, Erika Pietrolongo, Marco Onofrj, Valentina Torri Clerici, Silvia Bonanno, Laura Brambilla, Paolo Confalonieri, Vittorio Martinelli, Marta Radaelli, John Messina, Gıancarlo Comı, Carla Tortorella, Elena Luciannatelli, Maria Trojano, Caterina Senesi, Elena Tsantes, Franco Granella, MZ Conti, MR Rottoli, P. Bellantonio, Mariano Fischetti, Roberta Fantozzi, A Pala, S. Traccis, Giancarlo Di Battista, Maria Bianchi, Maria Donata Benedetti, Lorenzo Gaetani, Massimiliano Di Filippo, A Carolei, Rocco Totaro, Roberta Lanzillo, Vincenzo Brescia Morra, Rosa Coppola, Salvatore Cottone, Carlotta Chiavazza, Paola Cavalla, C. Leonardi, Umberto Aguglia, C Ziuliani, P Valla, Francesco Sasanelli, Paola Valentino, Aldo Quattrone, Policlinico G. Martino, Margherita Russo, Giuseppe Vita, Paolo Immovilli,
The SIMS-Trial showed that the 'Sapere Migliora' information aid (IA) for newly diagnosed people with multiple sclerosis (PwMS) effectively improved patient knowledge and satisfaction with care.The objectives of this paper are to assess the effectiveness of the IA in clinical practice and to compare the whole IA with the take-home booklet/website component alone.After updating the IA and replacing the CD with a website, a prospective, open-label non-randomised controlled trial compared the whole IA ( ...
Tópico(s): Family Support in Illness
2014 - SAGE Publishing | Multiple Sclerosis Journal
M. Brambilla, L. A. Lugiato, Vittorio Penna, F. Prati, Chr. Tamm, C. O. Weiß,
We show that the stationary transverse patterns, formed by the interaction of the modes of a frequency-degenerate family, are selected by the laser according to a specific variational principle. We discuss the phenomenon of spatial multistability, which consists in the coexistence of two or more different configurations for the same values of the control parameters. We establish a general connection between laser physics and hydrodynamics, by reformulating the dynamical equations of the laser in ...
Tópico(s): Nonlinear Dynamics and Pattern Formation
1991 - American Physical Society | Physical Review A
L. Harms, Arlie B. Bock, W Jänisch, José M. Valdueza, Jeffrey C. Weber, I. Link, Jacques De Keyser, A. Goossens, N. Wilczak, Christian Vedeler, Line Bjørge, E. Uvestad, Gabriele Conti, Kirsten M. Williams, Lionel Ginsberg, Saima Rafique, С. И. Рапопорт, Norman L. Gershfeld, G De La Meilleure, Luc Crevits, Jürgen Faiss, N. Heye, J. Blanke, Anna Sackmann, Oliver Kastrup, R. Doornbos, H. Bart van der Worp, L. Jaap Kappelle, Přemysl Bar, C. A. Davie, Gerry J. Barker, D. Brenton, D. H. Miller, Alan J. Thompson, FRANK B. BLOCK, Markus Schwarz, L. Delodovici, Fabio Baruzzi, G. Bonaldi, Amabile Borges Dario, Angela Marra, A. Mercuri, F. Dworzak, Paolo Cavallari, Paolo Confalonieri, Marco A. L. Zuffi, Carlo Antozzi, F. Cornelio, F. Baldissera, B. Chassande, Abdol A. Ameri, B. Eymard, M Poisson, A Vérier, P Brunet, Stefano Congia, P. L. Murgia, Antonino Cannas, Giuseppe Borghero, S. Uselli, Gisa Mellino, R. Ferrai, R. Lampis, Roberto Massa, B. Muzzetto, F. Giannini, S. Rossi, R. Cioni, Carlo D’Aniello, Alessia Guarneri, N. Battistini, Federico Ceriani, Antonio Santo, M. Poloni, John F. de Campo, F. Iglesias, M. V. Guitera, Castro Farinas, Julio Pascual, C Leno, José Berciano, I. W. Thorpe, B. E. Kendall, W. I. McDonald, Antoine Moulignier, Françoise Dromer, M. Baudrimont, Benoît Dupont, Joël Gozlan, Mohamed Amrani, Joan Petit, E Roullet, Roberto Sterzi, R. Causaran, Alessandro Protti, Marco Riva, F. Erminio, O. Arena, Fernando Villa, Elio Maccagnano, Maria Consolata Miletta, Francesco Spinelli, Tamir Ben‐Hur, J. Weidenfeldl, N.S.V.M. Prabhakara Rao, C. C. Chari, P. Laforet, Sophie Matheron, Don Adams, Ph. Chemouilli, M Desi, G. Said, P Davous, Françoise Lionnet, M. Pulik, Philippe Genet, Flore Rozenberg, L Cartier, Joaquim Castilló, J. G., Roque Villagra, L. de Saint Martin, Florence Mahieux, M. J. Manifacier, Kélli Renata Corrêa de Mattos, Catarina Queirós, L. Publio, V. Vinhas, A. C. PeÇanha-Martins, Antonieta Melo, U. Liska, U. Zifko, Herbert Budka, M. Drlicek, W. Grisold, Roland Kaufmann, R. Kaiser, Martin Czygan, Inês Afonso Gomes, Nicholas Jones, Sérgio Pereira da Cunha, E. Katiane EmbiruÇu, Verónica M. Vieira, ISABELLY BARROS DE ARAÚJO, Mónica Alexandra, A. C. Silva Ferreira, João Goês, P. Chemouilli, Israel‐Biet, Henri Masson, Carol Lacroix, J. Gasnault, B. Hildebrandt-Müller, Patrick Oschmann, Paul Krack, Wulf R. Willems, W. Dorndorf, Valéria Leite de Freitas, Aline Gomes Bittencourt, Daniel Fernandes, Matheus Hipólito do Nascimento, Mateus Dornelles Severo, D. Moraes, Maximilian Müller, K. Hasert, S. Merkelbach, К. Schimrigk, Bob W. van Oosten, Matthew Lai, C. H. Polman, Frits W. Bertelsmann, Suzanne Hodgkinson, Philippe Cabre, Laura Volpe, Didier Smadja, Jean Paul Vernant, H. Villaroya, K. Violleau, Amena Ben Younes‐Chennoufi, Natascha Baumann, P. Villanueva-Hemandez, J. Ballabriga, E. Basart, T. Arbizu, J. Perez-Serra, F. Vinuels, J.M. Girón, J Castilla, L. M. Redondo, G Izquierdo, Klaus Lauer, A.E. Henneberg, N. Bittmann, Daniel C. Link, Kurt H. Wollinsky, R. Möbner, Klaus Faßbender, J. Kuhnen, A. Schwartz, Michael G. Hennerici, Aaron Miller, O. Lider, Oded Abramsky, H. Weiner, Herman Leroy Offner, A. A. Vanderbark, E. Paoino, Enrico Fainardi, M. C. Addonizio, P Ruppi, Maria Rosalia Tola, Enrico Granieri, M Carreras, V. Sazdovitch, Anne Joutel, M H Verdier-Taillefer, O. Heinzlef, Celine M. Radder, Elisabeth Tournier‐Lasserve, R. E. Brenner, P. M. G. Munro, Steven Williams, Julie Bell, Clive Hawkins, Massimo Filippi, A. Campi, Vincent Dousset, N. Canal, Giacomo P. Comi, Jiahong Zhu, Frank Weber, R. Retska, Jane List, Linlin Zhang, M. Brock, Martin Klein, J. J. Heimans, E. A. van der Veen, A. B. M. F. Karim, M. Sarazin, N. Argentino, J. Y. Delattre, P. Derkinderen, Brigitte Buchwald, Gabriella Torres Schröter, G. Serve, Christina Franke, B. Conrad, Neil Kitchen, D.G.T. Thomas, Amanda Forman, Kie Kian Ang, Raymond R. Price, C. Stephens, Andrea Salmaggi, R. Nermni, Antonio Silvani, M. G. Forno, Roberto Luksch, A. Boiardi, H. Grzelec, C Fryze, P. E. Nowacki, B. Zdziarska, Marc Sanson, Patrick Mérel, Stephen Richard, Guy A. Rouleau, Gwenda Thomas, N. K. Olsen, P. Pfeiffer, Niels Egund, Søren M. Bentzen, Lars Johannesen, K. Mondrup, Carl H. Rose, Beata Zyluk, E. Wondrusch, Oscar Berger, N. Fast, K. A. Jellinger, Karlsruhe Lindner, A. Urman, Jean-Luc Thibault, C Duyckaerts, Helmer Strik, Bettina Müller, Elisa Richter, P. Krauseneck, Astrid Steinbrecher, M. Schabet, Christopher P. Hess, M. Bamberg, J. Dichgans, Carl Counsell, Chandler McLeod,
Cytomegalovirus (CMV) causes several neurological diseases in the late stages of AIDS, but their ante-mortem diagnosis is problematic.Clinical criteria (defining a presumptive diagnosis) and polymerase chain reaction $4 (PCR) assay from cerebrospinal fluid (CSF) were blindly used to predict the involvement of CMV in neurological disorders of 164 consecutive AIDS patients undergoing a lumbar puncture.During the follow-up, a definite diagnosis based on viral culture of CSF, clinical outcome and/or CNS ...
Springer Science+Business Media
Danilo Porro, Michele M. Bianchi, Luca Brambilla, Rossella Menghini, Davide Bolzani, Vittorio Carrera, Jefferson C. Lievense, Chi-Li Liu, Bianca Maria Ranzi, Laura Frontali, Lilia Alberghina,
ABSTRACT Interest in the production of l -(+)-lactic acid is presently growing in relation to its applications in the synthesis of biodegradable polymer materials. With the aim of obtaining efficient production and high productivity, we introduced the bovine l -lactate dehydrogenase gene ( LDH ) into a wild-type Kluyveromyces lactis yeast strain. The observed lactic acid production was not satisfactory due to the continued coproduction of ethanol. A further restructuring of the cellular metabolism was obtained ...
Tópico(s): Biofuel production and bioconversion
1999 - American Society for Microbiology | Applied and Environmental Microbiology
Francesco Ria, Loredana D’Ercole, Daniela Origgi, N. Paruccini, Luisa Pierotti, Osvaldo Rampado, V. Rossetti, S. Strocchi, A. Torresin, A. Torresin, Luisa Pierotti, Giacomo Belli, P. Bregant, Paola Isoardi, Alberto Mari, Andrea Nitrosi, Luca Nocetti, N. Paruccini, M. Quattrocchi, Anna Radice, Osvaldo Rampado, N. Scrittori, C. Sottocornola, S. Strocchi, M. Sutto, G. Zatelli, Domenico Acchiappati, Rosa Antonella Aoja, Marco Brambilla, M. Branchini, Vittorio Cannatà, T. Costi, C. Cutaia, Loredana D.’Ercole, Antonella Del Vecchio, S. Delle Canne, Maria Di Pasquale, Silvia Elisabetta, Cinzia Fabbri, Maria Daniela Faico, Daniele Fantinato, C. Ghetti, Marco Giannelli, Carlo Giordano, S. Grisotto, G. Guidi, Francesco Lisciandro, Luigi Manco, Pier Giorgio Marini, Paola Moresco, Nadia Oberhofer, Daniela Origgi, F. Palleri, C. Pasquali, Massimo Pasquino, Andrea Peruzzo, Giuseppe Petrillo, S. Pini, D. Rembado, Francesco Ria, L. Riccardi, R. Rosasco, Giulio Serelli, R. Soavi, M. Stasi, A. Taddeucci, E. Tonini, Annalisa Trianni, P. Turano, Giovanna Venturi, Daniele Zefiro, Felicia Zito,
Abstract The evaluation of radiation burden in vivo is crucial in modern radiology as stated also in the European Directive 2013/59/Euratom—Basic Safety Standard. Although radiation dose monitoring can impact the justification and optimization of radiological procedure, as well as effective patient communication, standardization of radiation monitoring software is far to be achieved. Toward this goal, the Italian Association of Medical Physics (AIFM) published a report describing the state of the ...
Tópico(s): Digital Radiography and Breast Imaging
2022 - Springer Nature | Insights into Imaging
Paolo Mocarelli, Larry L. Needham, Alessandro Marocchi, Donald G. Patterson, Paolo Brambilla, Pier Mario Gerthoux, L. Meazza, Vittorio Carreri,
2,3,7,8-Tetrachlorodibenzo-p-dioxin levels (TCDD) were measured in serum specimens from Seveso, Italy, residents, who were potentially highly exposed to the 1976 explosion, and in controls. The residents were chosen so as to represent those who did and did not develop chloracne. Levels of TCDD as high as 56,000 parts per trillion (ppt) were found in these serum specimens that were collected in 1976. These TCDD levels are the highest ever reported, and yet almost all clinical laboratory tests on these ...
Tópico(s): Carcinogens and Genotoxicity Assessment
1991 - Taylor & Francis | Journal of Toxicology and Environmental Health
M. Brambilla, F. Battipede, L. A. Lugiato, Vittorio Penna, F. Prati, Chr. Tamm, C. O. Weiß,
We analyze the interaction and the competition of a set of transverse cavity modes, which belong to a frequency-degenerate family. The laser turns out to be able to realize several different stationary spatial patterns, which differ in the transverse configuration of the intensity or of the field and are met by varying the values of the control parameters. A striking feature that emerges in almost all steady-state patterns is the presence of dark points, in which both the real and the imaginary ...
Tópico(s): Laser-Matter Interactions and Applications
1991 - American Physical Society | Physical Review A
Alessandro Talia, Sarah I. F. Daniel, Madeleine Miller‐Bottome, Daniela Brambilla, Denise Miccoli, Jeremy D. Safran, Vittorio Lingiardi,
There is currently little empirical evidence regarding how patients' attachment patterns manifest in individual psychotherapy. This study compared the in-session discourse of patients classified secure, dismissing, and preoccupied on the Adult Attachment Interview (AAI). Rather than focusing on content or form alone, this study analyzed how patients' discourse elicits and maintains emotional proximity with the therapist. The AAI was administered to 56 patients prior to treatment and one session for ...
Tópico(s): Personality Disorders and Psychopathology
2013 - Taylor & Francis | Attachment & Human Development
Roberto Miniero, Vittorio Abate, Gianfranco Brambilla, Enrico Davoli, Elena De Felip, Stefania Paola De Filippis, Elena Dellatte, Silvia De Luca, Roberto Fanelli, Elena Fattore, Fabiola Ferri, Igor Fochi, Anna Rita Fulgenzi, Nicola Iacovella, Anna Laura Iamiceli, Dario Lucchetti, Paolo Melotti, Ivo Moret, Rossano Piazza, Alessandra Roncarati, Alessandro Ubaldi, Stefano Zambon, Alessandro Di Domenico,
Fish and fishery products may represent one of the main sources of dietary exposure to persistent toxic substances (PTSs) such as polychlorinated dibenzodioxins, dibenzofurans, and biphenyls; polybromodiphenyl ethers; organochlorine pesticides; perfluorooctanoic acid and perfluorooctane sulfonate; and inorganic mercury and methyl mercury. In this study, PTS contamination of Mediterranean fish and crustaceans caught in Italian coastal waters was investigated in order to increase the representativeness ...
Tópico(s): Mercury impact and mitigation studies
2014 - Elsevier BV | The Science of The Total Environment
Nic Pacini, Vittorio Abate, Gianfranco Brambilla, Elena De Felip, Stefania Paola De Filippis, Silvia De Luca, Alessandro Di Domenico, Amilcare D'Orsi, Tiziana Forte, Anna Rita Fulgenzi, Nicola Iacovella, Luca Luiselli, Roberto Miniero, Anna Laura Iamiceli,
Twenty-eight fish muscle specimens from the main water bodies of the Campania Region were analyzed in our laboratory. On average, results showed a low contamination by PCDDs+PCDFs and a relatively more important presence of DL-PCBs. All specimens were compliant with EU regulatory maximum levels. Cumulative PCDD+PCDF+DL-PCB concentrations (TEQ(TOT)) were comprised in the range 0.223-11.4 pgWHO(97)-TEQ g(-1) fresh weight (fw). DL-PCB contribution to TEQ(TOT) was on average greater than 86% (range, 50. ...
Tópico(s): Effects and risks of endocrine disrupting chemicals
2012 - Elsevier BV | Chemosphere
M. Gironi, Vittorio Martinelli, Elena Brambilla, Roberto Furlan, Alberto E. Panerai, Gıancarlo Comı, Paola Sacerdote,
It has been reported that the opioid peptide beta-endorphin (BE) has immunosuppressive effects. Interferon beta (IFN-beta) is a well-established therapy for multiple sclerosis (MS), but immunological mechanisms underlying its beneficial effects in MS are partially undefined.To determine BE levels in peripheral blood mononuclear cells (PBMCs) of patients with relapsing-remitting MS during different phases of disease activity and the possible modulating effects of IFN-beta treatment on PBMC BE synthesis ...
Tópico(s): Immune Response and Inflammation
2000 - American Medical Association | Archives of Neurology
Gianvito Martino, Massimo Filippi, Vittorio Martinelli, Elena Brambilla, Gıancarlo Comı, L.M.E. Grimaldi,
T lymphocytes are the main cellular mediators in MS pathogenesis, and their activity is modulated by a complex cytokine network in which gamma-interferon (gamma-IFN) is considered essential. We have recently identified a new transplasmalemma Ca2+ influx activated by gamma-IFN in T lymphocytes (mainly CD4+) from patients with MS that makes T cells more susceptible to proliferation. To define the possible role of this Ca2+ influx as a marker of disease activity, we correlated its appearance with clinical ...
Tópico(s): Multiple Sclerosis Research Studies
1996 - Lippincott Williams & Wilkins | Neurology
Melissa Sorosina, Federica Esposito, Clara Guaschino, Ferdinando Clarelli, Nadia Barizzone, Ana Maria Osiceanu, Paola Brambilla, Elisabetta Mascia, Paola Cavalla, Paolo Gallo, Vittorio Martinelli, Maurizio Leone, Giacomo P. Comi, Sandra D’Alfonso, Filippo Martinelli Boneschi,
We correlated the weighted genetic risk score measured using 107 established susceptibility variants for multiple sclerosis (MS) with the age at onset in bout-onset (BOMS, n=906) and progressive-onset MS Italian patients (PrMS) ( n=544). We observed an opposite relationship in the two disease courses: a higher weighted genetic risk score was associated with an earlier age at onset in BOMS (rho= −0.1; p=5 × 10 −3 ) and a later age at onset in PrMS cases (rho=0.07; p=0.15) ( p of difference of regression=1.4 × 10 − ...
Tópico(s): Peripheral Neuropathies and Disorders
2014 - SAGE Publishing | Multiple Sclerosis Journal
Paolo Mocarelli, Pier Mario Gerthoux, Enrica Ferrari, Donald G. Patterson, Stephanie Kieszak, Paolo Brambilla, Nicoletta Vincoli, Stefano Signorini, Pierluigi Tramacére, Vittorio Carreri, Eric J. Sampson, Wayman E. Turner, Larry L. Needham,
Background 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD or dioxin), is commonly considered the most toxic man-made substance. We have previously shown that high serum concentrations of TCDD in parents from Seveso, Italy, were linked to their having a relative increase in the number of female births after the parents exposure to a release of dioxin in 1976. We have continued the study to determine whether the parents' sex and/or age at exposure affected the sex ratio of their children. Methods We measured ...
Tópico(s): Global Maternal and Child Health
2000 - Elsevier BV | The Lancet
Antonio Torsello, Frăncesca Brambilla, Laura Tamiazzo, Ilaria Bulgarelli, D. Rapetti, Elena Bresciani, Vittorio Locatelli,
Tópico(s): Diet and metabolism studies
2007 - Springer Science+Business Media | Journal of Endocrinological Investigation
Muhammad Abubakar Yamin, Michael Dayan, Letizia Squarcina, Paolo Brambilla, Vittorio Murino, Vaibhav A. Diwadkar, Diego Sona,
Analysis of dynamic functional connectivity allows for studying the time variant behavior of brain connectivity during specific tasks or at rest. There is, however, a debate around the significance of studies analyzing the dynamic connectivity, as it is usually estimated using short subsequences of the entire time-series. Therefore, a question that naturally arises is whether the dynamic connectivity information is robust enough to compare connectivity matrices. In this paper we investigate the ...
Tópico(s): Advanced Neuroimaging Techniques and Applications
2019 - Springer Science+Business Media | Lecture notes in computer science
Gianfranco Brambilla, Stefania Paola De Filippis, Anna Laura Iamiceli, Nicola Iacovella, Vittorio Abate, Vincenzo Aronica, Vincenzo Di Marco Lo Presti, Alessandro Di Domenico,
An observational study was designed to assess the bioaccumulation of polychlorodibenzodioxins (PCDD) and polychlorodibenzofurans (PCDF), dioxin-like polychlorobiphenyls (DL-PCB), and 13 selected polybromodiphenylethers (PBDE) in autochthonous pigs reared in the Nebrodi Park of Sicily (Italy). Perirenal fat and liver samples were drawn from animals representative of three different outdoor farming systems and from wild pigs and then analyzed for the chemicals mentioned previously. The highest concentrations ...
Tópico(s): Carcinogens and Genotoxicity Assessment
2011 - Elsevier BV | Journal of Food Protection
A. Pau, S. Turtas, E. Sehrbundt Viale, M. Brambilla, Gian Vittorio Campus, G Zirattu, Giuseppe Viale,
Tópico(s): Botulinum Toxin and Related Neurological Disorders
1985 - Springer Science+Business Media | Acta Neurochirurgica
Denis Peruzzo, Umberto Castellani, Cinzia Perlini, Marcella Bellani, Veronica Marinelli, Gianluca Rambaldelli, Antonio Lasalvia, Sarah Tosato, Katia De Santi, Vittorio Murino, Mirella Ruggeri, Paolo Brambilla,
Tópico(s): Schizophrenia research and treatment
2014 - Springer Science+Business Media | Journal of Neural Transmission
Luca Cozzaglio, Matteo Cimino, Giovanni Mauri, Antonella Ardito, Vittorio Pedicini, Dario Poretti, Giorgio Brambilla, Matteo Sacchi, Alessandra Melis, Roberto Doci,
Tópico(s): Biliary and Gastrointestinal Fistulas
2011 - Springer Science+Business Media | Journal of Gastrointestinal Surgery
Francesca Lavatelli, Francesca Brambilla, Veronica Valentini, Paola Rognoni, Simona Casarini, Dario Di Silvestre, Vittorio Perfetti, Giovanni Palladini, Gabriele Sarais, Pierluigi Mauri, Giampaolo Merlini,
An excess of circulating monoclonal free immunoglobulin light chains (FLC) is common in plasma cell disorders. A subset of FLC, as amyloidogenic ones, possess intrinsic pathogenicity. Because of their complex purification, little is known on the biochemical features of serum FLC, possibly related to their pathogenic spectrum. We developed an immunopurification approach to isolate serum FLC from patients with monoclonal gammopathies, followed by proteomic characterization. Serum monoclonal FLC were ...
Tópico(s): Drug Transport and Resistance Mechanisms
2011 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
Gianvito Martino, Massimo Filippi, Vittorio Martinelli, Elena Brambilla, Carla Gobbi, Gıancarlo Comı, Luigi Grimaldi,
BACKGROUND Interferon (IFN)-γ exerts a multiplicity of actions potentially relevant for the pathogenesis of multiple sclerosis, including the expression of a transplasmalemma calcium (Ca 2+ ) influx leading to an intracellular Ca 2+ ([Ca 2+ ] i ) increase able to lower T lymphocyte threshold of excitability. It has been previously shown in a cross sectional cumulative study that this influx is associated with clinical and MRI evidence of disease activity. METHODS To evaluate the temporal relation between disease activity ...
Tópico(s): Viral Infections and Immunology Research
1997 - BMJ | Journal of Neurology Neurosurgery & Psychiatry