Sanja Mijatović, Danijelа Maksimović-Ivanić, J. Radovic, Djordje Miljković, Lj. Harhaji, O. Vuckovic, Stanislava Stošić‐Grujičić, Maja Stojković, Vladimir Trajkovič,
Tópico(s): Lipid metabolism and disorders
2005 - Springer Nature | Cellular and Molecular Life Sciences
Djordje Miljković, Tatjana Samardžić, Ivana Cvetković, Marija Mostarica Stojković, Vladimir Trajkovič,
Free radical nitric oxide (NO), generated by inducible nitric oxide synthase (iNOS) in astrocytes and macrophages, has been implicated in CNS inflammatory disorders such as multiple sclerosis and its animal model experimental autoimmune encephalomyelitis (EAE). Mycophenolic acid (MPA), a selective inhibitor of inosine monophosphate dehydrogenase (IMPDH), inhibited interferon-gamma (IFN-gamma) + lipopolysaccharide (LPS)-induced NO production dose-dependently in astrocytes, but not in macrophages. The effect ...
Tópico(s): Neutrophil, Myeloperoxidase and Oxidative Mechanisms
2002 - Wiley | Glia
Djordje Miljković, Ivana Cvetković, O. Vuckovic, Stanislava Stošić‐Grujičić, Mirjana Stojković, Vladimir Trajkovič,
Tópico(s): Bioactive Compounds and Antitumor Agents
2003 - Springer Nature | Cellular and Molecular Life Sciences
Svetlana Popadić, Zorica Ramić, Ljiljana Medenica, Maja Stojković, Vladimir Trajkovič, Dušan Popadić,
<i>Background:</i> Vitamin A and D analogues play an important role in epidermal homeostasis and are used in the treatment of various skin diseases. The failure of retinoid and vitamin D treatments is sometimes difficult to explain. <i>Methods:</i> We analyzed the effect of all-<i>trans</i> retinoic acid (all-<i>trans</i> RA), 13-<i>cis</i> retinoic acid (13-<i>cis</i> RA), ergocalciferol and cholecalciferol in keratinocyte cultures ...
Tópico(s): Phytochemical compounds biological activities
2008 - Karger Publishers | Skin Pharmacology and Physiology
Lj Ziropadja, Elka Stefanova, M. Petrovic, Tanja Stojković, Vladimir Kostić,
Apathy and depression are among the most common psychiatric and behavioral disorders associated with Parkinson's disease (PD). The objective of this study was to examine the prevalence and demographic and clinical correlates of apathy and depression in a clinical population-based sample of patients with PD and to assess whether apathy may present as a primary behavioral disturbance independent from depression and cognitive impairment. A series of 360 PD patients underwent psychiatric investigation ...
Tópico(s): Autism Spectrum Disorder Research
2011 - Elsevier BV | Parkinsonism & Related Disorders
Svetlana Popadić, Dušan Popadić, Zorica Ramić, Mirjana Stojković, Vladimir Trajkovič, Marija Milinković, Ljiljana Medenica,
Tópico(s): Photodynamic Therapy Research Studies
2006 - Springer Science+Business Media | Cell Biology and Toxicology
Elka Stefanova, Ljubomir Žiropadja, M. Petrovic, Tanja Stojković, Vladimir Kostić,
A limited number of studies examined anxiety in Parkinson disease (PD). Questionable validity of the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) defined anxiety disorders in PD population as well as a lack of validated rating scales hampered the investigation in this field.To screen for prevalence of anxiety symptoms and their associated demographic and clinical features in an outpatient-based cohort with PD.A consecutive series of 360 patients with PD underwent investigation ...
Tópico(s): Attention Deficit Hyperactivity Disorder
2013 - SAGE Publishing | Journal of Geriatric Psychiatry and Neurology
Vladana Marković, Federica Agosta, Elisa Canu, Alberto Inuggi, Igor Petrović, Iva Stanković, Francesca Imperiale, Tanja Stojković, Vladimir Kostić, Massimo Filippi,
To assess whether a functional dysregulation of the habenula and amygdala, as modulators of the reward brain circuit, contributes to Parkinson disease (PD) punding.Structural and resting-state functional MRI were obtained from 22 patients with PD punding, 30 patients with PD without any impulsive-compulsive behavior (ICB) matched for disease stage and duration, motor impairment, and cognitive status, and 30 healthy controls. Resting-state functional connectivity of the habenula and amygdala bilaterally ...
Tópico(s): Botulinum Toxin and Related Neurological Disorders
2017 - Lippincott Williams & Wilkins | Neurology
Dani Varghese, Mirjana Radulović, S.M. Stojković, Vladimir Crnojević,
This paper systematically reviews the potential of the Sentinel-2 (A and B) in assessing drought. Research findings, including the IPCC reports, highlighted the increasing trend in drought over the decades and the need for a better understanding and assessment of this phenomenon. Continuous monitoring of the Earth’s surface is an efficient method for predicting and identifying the early warnings of drought, which enables us to prepare and plan the mitigation procedures. Considering the spatial, temporal, ...
Tópico(s): Climate variability and models
2021 - Multidisciplinary Digital Publishing Institute | Remote Sensing
M. Petrovic, Elka Stefanova, Ljubomir Žiropadja, Tanja Stojković, Vladimir Kostić,
Background Parkinson's disease [PD] is associated with wide variety of neuropsychiatric symptoms, although it is primarily considered as a movement disorder. Objective To examine whether PD patients can be meaningfully classified into subgroups according to their neuropsychiatric symptoms, reported by their caregivers. Methods Three hundred and sixty PD patients [mean age = 63.5, SD = 10.3] from the academic clinical setting were assessed with the 12-subscale Neuropsychiatric Inventory Questionnaire [NPI]. ...
Tópico(s): Neurological disorders and treatments
2016 - Elsevier BV | Journal of the Neurological Sciences
Silvia Basaia, Federica Agosta, Ibai Díez, Elisenda Bueichekú, Federico d’Oleire Uquillas, Manuel Delgado‐Alvarado, César Caballero‐Gaudes, María Rodríguez‐Oroz, Tanja Stojković, Vladimir Kostić, Massimo Filippi, Jorge Sepulcre,
The genetic traits that underlie vulnerability to neuronal damage across specific brain circuits in Parkinson's disease (PD) remain to be elucidated. In this study, we characterized the brain topological intersection between propagating connectivity networks in controls and PD participants and gene expression patterns across the human cortex - such as the SNCA gene. We observed that brain connectivity originated from PD-related pathology epicenters in the brainstem recapitulated the anatomical distribution ...
Tópico(s): Genetic Neurodegenerative Diseases
2022 - Elsevier BV | NeuroImage Clinical
Djordje Miljković, Miloš Marković, Natalija Bogdanovic, Marija Mostarica Stojković, Vladimir Trajkovič,
Nitric oxide (NO) is a highly reactive free radical with profound tumoricidal activity, produced by both macrophages and tumor cells. While it has been postulated that necrotic tumor cells can augment macrophage anti-tumor action, we investigated the effect of tumor cell necrosis on NO synthesis and viability of L929 fibrosarcoma and C6 astrocytoma cell lines. The presence of necrotic tumor cells dose-dependently reduced NO production in IFN-gamma stimulated L929 cells, and rescued them from NO-dependent ...
Tópico(s): Eicosanoids and Hypertension Pharmacology
2002 - Elsevier BV | Cellular Immunology
Tamara Alempijević, Igor Dumic, Jelena Veličković, Milica Stojković Lalošević, Vladimir Nikolić, Ivan Palibrk,
Cirrhosis-associated immune dysfunction syndrome (CAIDS) has been identified in patients with liver cirrhosis (LC), predisposing them to a wide variety of infections. In patients with LC, healthcare-associated infections involving multi-drug resistant (MDR) bacteria have increased significantly over the last decades. Among them, hospital-acquired urinary tract infections (HA-UTI) are the most common. This study aimed to investigate the rates of antimicrobial resistance among patients with LC and HA- ...
Tópico(s): Drug-Induced Hepatotoxicity and Protection
2019 - BioMed Central | BMC Infectious Diseases
Dušan Keckarević, Biljana Čuljković, Dušanka Savić‐Pavićević, Oliver Stojković, Vladimir Kostić, Slobodanka Vukosavić, Stanka Romac,
A number of human hereditary neuromuscular and neurodegenerative disorders are caused by the expansion of trinucleotide repeats within certain genes. Here we report the results of the analysis of five trinucleotide repeats containing genes (SCA1, MJD/SCA3, DRPLA, FRDA and MD) in HD patients and in a group of healthy controls. Allelic frequency distributions for SCA1 and FRDA genes were shifted toward larger alleles in the group of unrelated HD patients, compared to healthy controls. This linkage ...
Tópico(s): Neurological disorders and treatments
2000 - Taylor & Francis | Journal of Neurogenetics
Elka Stefanova, Aleksandra Pavlović, Zagorka Jovanović, Nikola Veselinović, Ida Despotovic, Tanja Stojković, Nadežda Šternić, Vladimir Kostić,
The vascular risk factors are associated with an increased risk for vascular cognitive decline (VCD), but also with Alzheimer disease (AD).To investigate vascular risk factors in relation to AD and VCD, with a non-invasive neurosonological methods in a clinical settings.A total of 296 patients with AD and 237 patients with VCD were included in the study. Hypertension, hyperlipidemia, diabetes mellitus, stroke, and white matter changes (p 50%" (p=0.007) and present plaques (p<0.001) more frequently compared ...
Tópico(s): Dementia and Cognitive Impairment Research
2012 - Elsevier BV | Journal of the Neurological Sciences
Nebojša Atanacković, Veselin Dragišić, J. Stojković, Petar Papić, Vladimir Živanović,
Tópico(s): Water Quality and Pollution Assessment
2013 - Springer Science+Business Media | Environmental Science and Pollution Research
G. Jevtić, Tatjana Nikolić, Aleksandar Mirčić, T. Stojković, Milica Velimirović, Vladimir Trajkovič, Ivanka Marković, Alexander M. Trbovich, Nevena V. Radonjić, Nataša Petronijević,
Phencyclidine (PCP) acts as a non-competitive antagonist of glutamatergic N-methyl-d-aspartate receptor. Its perinatal administration to rats causes pathophysiological changes that mimick some pathological features of schizophrenia (SCH). Numerous data indicate that abnormalities in mitochondrial structure and function could be associated with the development of SCH. Mitochondrial dysfunction could result in the activation of apoptosis and/or autophagy. The aim of this study was to assess immediate ...
Tópico(s): Autophagy in Disease and Therapy
2015 - Elsevier BV | Progress in Neuro-Psychopharmacology and Biological Psychiatry
Elisa Canu, Federica Agosta, Vladana Marković, Igor Petrović, Iva Stanković, Francesca Imperiale, Tanja Stojković, Massimiliano Copetti, Vladimir Kostić, Massimo Filippi,
To assess brain white matter tract alterations in patients with Parkinson's disease and punding (PD-punding) compared with controls and PD cases without any impulsive-compulsive behaviour.Forty-nine PD patients (21 PD-punding and 28 PD with no impulsive-compulsive behaviours) and 28 controls were consecutively recruited. Clinical, cognitive and psychopathological evaluations were performed. Diffusion tensor MRI metrics of the main white matter tracts were assessed using a tractography approach.Compared ...
Tópico(s): Botulinum Toxin and Related Neurological Disorders
2017 - Elsevier BV | Parkinsonism & Related Disorders
Dušica Stamenković, Mihailo Bezmarević, Suzana Bojić, Dragana Unić-Stojanović, Dejan Stojković, Damjan Slavković, Vladimir Bančević, Nebojša Marić, Μενέλαος Καρανικόλας,
Local anesthetic wound infiltration (WI) provides anesthesia for minor surgical procedures and improves postoperative analgesia as part of multimodal analgesia after general or regional anesthesia. Although pre-incisional block is preferable, in practice WI is usually done at the end of surgery. WI performed as a continuous modality reduces analgesics, prolongs the duration of analgesia, and enhances the patient’s mobilization in some cases. WI benefits are documented in open abdominal surgeries ( ...
Tópico(s): Pain Management and Opioid Use
2021 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Radomir Naumović, Svetlana Pavlović, D Stojković, Gordana Basta-Jovanović, Vladimir Nešić,
There is not enough epidemiologic data of biopsy proven renal diseases. This is the first report of clinicopathologic correlations over a period of 20 years from central Balkan country-Serbia.A retrospective review of reports of 2 362 native renal biopsies performed on patients at the leading nephrology unit in Serbia from 1987 to 2006 was undertaken. Patients were divided in two groups according to age: younger ( or=60 years old).The annual incidence of renal biopsies increased from 3.9 p.m.p./year ...
Tópico(s): Vasculitis and related conditions
2008 - Oxford University Press | Nephrology Dialysis Transplantation
Goran Kaludjerovic, Djordje Miljković, Miljana Momčilović, V.M. Djinović, Marija Mostarica Stojković, Tibor J. Sabo, Vladimir Trajkovič,
The anticancer activity of platinum complexes has been known since the discovery of classical Pt(II)-based drug cisplatin. However, Pt(IV) complexes have greater inertness than corresponding Pt(II) complexes, thus allowing the oral administration and reducing the toxicity associated with platinum-based chemotherapy. Here, we describe the in vitro antitumor activity of some novel Pt(IV)-based agents against mouse fibrosarcoma L929 cells and human astrocytoma U251 cells. The cytotoxicity of 2 Pt(IV) ...
Tópico(s): Synthesis of Tetrazole Derivatives
2005 - Wiley | International Journal of Cancer
Lazar Rakočević, Ivana Stojković Simatović, Aleksandar D. Maksić, Vladimir Rajić, Svetlana Štrbac, Irina Srejić,
PtAu nanoparticles spontaneously deposited on graphene support, PtAu/rGO, have shown remarkably high catalytic activity for hydrogen evolution reaction (HER) in sulfuric acid solution. SEM images of the PtAu/rGO electrode surface showed that Pt nanoparticles that are non-uniform in size occupy both the edges of previously deposited uniform Au nanoparticles and the edges of graphene support. XPS analysis showed that the atomic percentages of Au and Pt in PtAu/rGO were 0.6% and 0.3%, respectively. ...
Tópico(s): Electrochemical Analysis and Applications
2021 - Multidisciplinary Digital Publishing Institute | Catalysts
Miodrag Ostojić, Dragan Sagić, Branko Beleslin, Robert Jung, Zoran Perišić, Nikola Jagić, Milan Nedeljković, Ljupco Mangovski, Bratislav Milosavljevic, Siniša Stojković, Dejan Orlić, Želimir Antonić, Vladimir Miloradović, Dragan Topic, Dragica Paunovic,
To compare clinical efficacy and safety of stents eluting limus drugs from biodegradable polymer - Nobori, or durable polymer - Cypher.From May to August 2006, 107 patients with 142 coronary artery lesions were treated with either Nobori, Biolimus A9 eluting stent (54) or Cypher, Sirolimus eluting stent (53) in five centres. The two groups were well matched for baseline clinical and angiographic characteristics. The in-stent late loss at nine months, the primary endpoint of the study, was 0.10+/-0.26 ...
Tópico(s): Cardiac Valve Diseases and Treatments
2008 - European Association of Percutaneous Cardiovascular Interventions | EuroIntervention
Elka Stefanova, Milica Ječmenica‐Lukić, Ljubomir Žiropadja, Vladana Marković, Tanja Stojković, Aleksandra Tomić, Nataša Mišković, Vladimir Kostić,
Abstract Cognitive loading aggravates the freezing of gait (FoG), which is observed in approximately 50% of patients with Parkinson’s disease (PD) in the advanced stages. To investigate whether a specific pattern of executive deficits, that is, attentional set-shifting and/or inhibitory control, are associated with FoG in PD, 30 PD patients with FoG (PD-FoG+) and 36 PD patients without FoG (PD-FoG−) and 22 control healthy subjects were examined with a comprehensive neuropsychological battery. Intra- ...
Tópico(s): Functional Brain Connectivity Studies
2014 - Cambridge University Press | Journal of the International Neuropsychological Society
Мilena Stojkovic, Branimir Radmanović, Mirjana Jovanović, Vladimir Janjić, Nemanja Murić, Dragana Ignjatović Ristić,
Risperidone is one of the most commonly used antipsychotics (AP), due to its safety and efficacy in reducing psychotic symptoms. Despite the favorable side effect profile, the therapy is accompanied by side effects due to the non-selectivity of this medicine. This review will briefly highlight the most important basic and clinical findings in this area, consider the clinical effects of AP-induced hyperprolactinemia (HPL), and suggest different approaches to the treatment.The route of application of ...
Tópico(s): Treatment of Major Depression
2022 - Frontiers Media | Frontiers in Psychiatry
C. Tulić, Miodrag Lazić, Emina Savić, Dušan Popadić, Jelena Djukic, D Spasić, Miloš Marković, Zorica Ramić, Marija Mostarica‐Stojković, Vladimir Trajkovič,
The aim of the study was to correlate the preoperative activity of Th1 and Th17 cytokine axes with the development of sepsis after radical cystectomy. The study involved twenty patients with the infiltrative transitional cell carcinoma of the urinary bladder without previous radiotherapy/chemotherapy, who underwent open radical cystectomy with urinary diversion. Preoperative plasma concentrations of Th1 cytokines interleukin 12 (IL-12) and interferon gamma (IFN-γ), and Th17 cytokines IL-23 and IL- ...
Tópico(s): Immune cells in cancer
2011 - John Libbey Eurotext | European Cytokine Network
Djordje Miljković, O. Vuckovic, Ljubica Harhaji-Trajković, Zoran Nikolić, Vladimir Trajkovič, Maja Stojković, Ivana Cvetković,
Tópico(s): Fibroblast Growth Factor Research
2004 - Springer Nature | Cellular and Molecular Life Sciences
Djordje Miljković, Tatjana Samardžić, Mirjana Stojković, Stanislava Stošić‐Grujičić, Dušan Popadić, Vladimir Trajkovič,
Highly reactive gaseous free radical nitric oxide (NO), generated by astrocytes and infiltrating macrophages is implicated in inflammatory destruction of brain tissue, including that occurring in multiple sclerosis. Therefore, the influence of immunosuppressive drug leflunomide on inducible nitric oxide synthase (iNOS)-dependent NO production in rat astrocytes and macrophages was investigated. Under the same cultivating conditions, leflunomide's active metabolite A77 1726 caused a dose-dependent decrease ...
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2001 - Elsevier BV | Brain Research
Iva Stanković, Igor Petrović, Tatjana Pekmezović, Vladana Marković, Tanja Stojković, Nataša Dragaševič-Mišković, Marina Svetel, Vladimir Kostić,
Clinical correlates of autonomic nervous system (ANS) dysfunction in early Parkinson's disease (PD) have been addressed mainly in a cross-sectional way.This is a combined cross-sectional and longitudinal prospective study of ANS dysfunction using the SCOPA-AUT in PD patients at the Hoehn and Yahr stage 1 with disease duration <2 years. PD patients (n = 107) were compared to healthy controls (HC, n = 79), and then followed-up for over 3 years. The severity of PD, depression, anxiety, apathy and cognitive ...
Tópico(s): Botulinum Toxin and Related Neurological Disorders
2019 - Elsevier BV | Parkinsonism & Related Disorders
Giulia Longoni, Federica Agosta, Vladimir Kostić, Tanja Stojković, Elisabetta Pagani, Tatjana Stošić-Opinćal, Massimo Filippi,
We investigated the diagnostic accuracy of brainstem MRI measurements in patients with different progressive supranuclear palsy (PSP) syndromes and Parkinson's disease (PD). Using 3D T1-weighted images, midbrain, and pons areas, as well as superior (SCP) and middle cerebellar peduncle (MCP) widths were measured in 10 patients with Richardson's syndrome (PSP-RS), 10 patients with PSP-parkinsonism (PSP-P), 25 patients with PD, and 24 healthy controls. The ratio between pons and midbrain areas (pons/midbrain), ...
Tópico(s): Advanced Neuroimaging Techniques and Applications
2010 - Wiley | Movement Disorders