Lana Saleh, J. Martin Bollinger,
A tryptophan 48 cation radical (W48+•) forms concomitantly with the Fe2(III/IV) cluster, X, during activation of oxygen for tyrosyl radical (Y122·) production in the R2 ... class I ribonucleotide reductase (RNR) from Escherichia coli. W48+• is also likely to be an intermediate in ... the RNR holoenzyme. The kinetics of decay of W48+• and formation of tyrosyl radicals during O2 activation ( ... the residue thought to propagate the radical from W48+• into R1 during turnover), or both replaced by ... mM) mediates a rapid radical-transfer equilibrium between W48 and Y356. Cation-mediated propagation of the radical ...
Tópico(s): Metalloenzymes and iron-sulfur proteins
2006 - American Chemical Society | Biochemistry
... Near-infrared and CO observations of W40 and W48. Zeilik, M., II ; Lada, C. J. Abstract Results ... II regions W40 (G28.8+3.5) and W48 (G35.2-1.7). The millimeter observations involved ... in W40, two close compact IR components in W48, a strong peak of CO emission in W40, and two CO emission peaks in W48. It is found that: (1) the measured velocities ... difference is negative in W40 and positive in W48; (3) the velocities of carbon recombination lines fall ... results are shown to indicate that W40 and W48 lie at the edges of molecular clouds and ...
Tópico(s): Atmospheric Ozone and Climate
1978 - IOP Publishing | The Astrophysical Journal
Suzanne M. Jan de Beur, Paul D. Miller, Thomas J. Weber, Munro Peacock, Karl Insogna, Rajiv Kumar, Diana Luca, Christina Theodore‐Oklota, Kathy Lampl, Javier San Martín, Thomas O. Carpenter,
... group had paired bone biopsies at baseline and W48. Mean ± SE histomorphometric values for the 8/10 ... time (MLT) was 1672 (1102, 2929) days. At W48, histomorphometric indices improved as shown by mean percentage ... at baseline to 3.6 (2.9) at W48 (p=0.020) and to 3.3 (2. ... 34 (11) at baseline to 39 (10) at W48 (p=0.059) and to 42 (10) at ... increased from 41 (14) to 47 (12) at W48 (p=0.075) and to 49 (12) at ... at baseline to 8.6 (4.2) at W48 (n=10; p=0.004). By W72, all ... to enrollment. One subject discontinued treatment prior to W48 to treat tumor progression with chemotherapy. There was ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2019 - Endocrine Society | Journal of the Endocrine Society
Joseph S. Onello, J. A. Phillips, P. Benaglia, W. M. Goss, Yervant Terzian,
... Aperture Synthesis Imaging of Partially Ionized Gas in W48 Onello, Joseph S. ; Phillips, J. A. ; Benaglia, P. ; ... of cool gas surrounding the H II region W48 at the H168 alpha and C168 alpha transition frequencies. Previous single-dish observations of W48 showed that the 168 alpha recombination spectrum was ... the Stromgren sphere. High spatial resolution imaging of W48 reveals that the strong C(+) and S(+) lines ... Astronomy; ISM: H II REGIONS; ISM: INDIVIDUAL ALPHANUMERIC: W48; RADIO LINES: ISM full text sources ADS | data ...
Tópico(s): Ionosphere and magnetosphere dynamics
1994 - IOP Publishing | The Astrophysical Journal
Produção Nacional
Revisado por pares
David Isenberg, Richard Furie, Nicholas S. Jones, Pascal Guibord, Joshua Galanter, C. Lee, Anna G McGregor, Balázs I. Tóth, Julie Rae, Olivia Hwang, Armend Lokku, Pedro C. Miranda, Viviane de Oliveira Nogueira Souza, Juan José Jaller-Raad, A. Fernandes, Rodrigo García Salinas, Leslie W. Chinn, Michael J. Townsend, Alyssa Morimoto, Katie Tuckwell,
... W36. The primary endpoint was SRI-4 at W48. Post hoc subgroup analyses were conducted based on ... in Latin America, USA, and Western Europe. At W48, the SRI-4 response rates for FEN 150 ... dependent RNA signature highly expressed in plasmablasts by W48 compared to PBO; C4 levels modestly improved with ... Table 2). Table 1. SRI-4 Response (%) at W48 in Primary Analysis and in Post-hoc Patient ... FEN 200 mg BID SRI-4 Response (%) at W48 44 n =84 51 n =87 52 n = ... 200 mg BID Median (%) Change from Baseline at W48 Plasmablast signature -19.7% n =52 -54.3% * ...
Tópico(s): Lymphoma Diagnosis and Treatment
2020 - BMJ | Annals of the Rheumatic Diseases
Laurent Peyrin‐Biroulet, Remo Panaccione, C Gasink, Timothy Hoops, James Izanec, Tony Ma, M Nazar, Ivana Bravatà, Marjolein Lahaye, Peter M. Irving, Edward V. Loftus, Silvio Danese, B E Sands,
... and the end of maintenance (SEAVUE W52, STARDUST W48). Fistula resolution was defined as closure of all fistulas. Pts with missing data at W52/W48 were considered to not have been in fistula ... fistulas at baseline had complete fistula resolution at W48. Of the 9 pts in fistula resolution, 2 were receiving q12w at W48, 6 were receiving q8w, and 1 was receiving ... without fistula resolution, 2 were receiving q12w at W48, 3 were receiving q8w, 1 was receiving q4w and 4 discontinued before W48. In both studies, among pts with evaluable samples ...
Tópico(s): Microscopic Colitis
2022 - Oxford University Press | Journal of Crohn s and Colitis
Claudine Duvivier, Myrto Astriti, Anne‐Geneviève Marcelin, Jade Ghosn, Hocine Aït-Mohand, Luminita Schneider, Rachid Agher, François Bricaire, Dominique Costagliola, Vincent Cálvez, Gilles Peytavin, Christine Katlama,
... 4, 12, 24 and every 3 months until W48. The primary end-point was the percentage (%) of patients with viral load < 400 copies/ml at W48. Intent-to-treat (ITT) (missing values or change ... median CD4 count was 84 cells/mm3. At W48 by ITT analysis, the % patients with viral load < ... analysis. The median decrease in viral load at W48 was -3.83 log10 copies/ml (-0.1; - ... ml. Ten patients discontinued the study treatment before W48: adverse events (eight), patient's will (one) and ...
Tópico(s): HIV/AIDS Research and Interventions
2003 - SAGE Publishing | Antiviral Therapy
Lana Saleh, Carsten Krebs, Brenda A. Ley, Sunail Naik, Boi Hanh Huynh, J. Martin Bollinger,
... ET) from the near-surface residue, tryptophan 48 (W48), to a (Fe(2)O(2))(4+) complex ... Fe(IV)Fe(III) cluster, X, and a W48 cation radical (W48(+)(*)). The latter may be reduced from solution to ... that is probably the precursor to the X-W48(+)(*) diradical state in the reaction of the wild- ... of the observation that in R2 variants with W48 replaced with alanine (A), the otherwise disabled ET ...
Tópico(s): Metal complexes synthesis and properties
2004 - American Chemical Society | Biochemistry
Carsten Krebs, Shuxian Chen, Jeffrey Baldwin, Brenda A. Ley, U R Patel, Dale E. Edmondson, Boi Hanh Huynh, J. Martin Bollinger,
... earlier work and in the preceding paper that W48 mediates, by a shuttling mechanism in which it ... type R2 protein and is ascribed to the W48 cation radical, is not observed in the reaction ... diiron cluster. These results suggest that substitution of W48 with phenylalanine impairs the pathway through which the ... 4+, which in wild-type R2 would oxidize W48 to form X and the W48+•, instead oxidizes Y122 to form the X-Y•. ...
Tópico(s): Porphyrin and Phthalocyanine Chemistry
2000 - American Chemical Society | Journal of the American Chemical Society
Sophie Vieujean, Jean‐Philippe Loly, Layla Boutaffala, Paul Meunier, Cathérine Reenaers, Alexandra Briquet, Chantal Lechanteur, Étienne Baudoux, Yves Béguin, Édouard Louis,
... were performed at baseline, Week [W]12 and W48. The main judgement criterion for efficacy was the ... efficacy criteria included assessment of the stricture at W48 and evolution of clinical scores at W12 and W48. Results We performed 11 MSC injections in 10 ... three partial]. Seven patients were re-evaluated at W48 [one dilated, one operated, and one lost to ... evolution of clinical scores between W0, W12, and W48 was not statistically significant. Conclusions MSCs injection in ...
Tópico(s): Autoimmune and Inflammatory Disorders
2021 - Oxford University Press | Journal of Crohn s and Colitis
Yogesh Punekar, Daniel Parks, Mihir Joshi, SIMARJIT KAUR, Lee Evitt, Vasiliki Chounta, M. Radford, D. Jha, Shannon Ferrante, Sophia Sharma, Jean van Wyk, Annemiek de Ruiter,
... mL in a single measurement) at week 48 (W48) and week 96 (W96). Other outcomes included virological suppression (VS; < 50 copies/mL) and discontinuations (W48 and W96). Estimates were calculated for VF, VS ... 95% CI: 0.0–1.6), respectively, at W48. VSS rate at W48 was 85.0% (95% CI: 82.3–87. ... 2.1–14.4) of patients, respectively, at W48. Similar results were observed at W96. Conclusions Treatment ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2021 - Wiley | HIV Medicine
Tran Ngoc Huu, Tran Thi Ngoc Giau, Phan Ngoc Ngan, Tran Thi Bich Van, Nguyễn Quốc Khương,
... P solubilizing PNSB (no inoculated PNSB, Rhodobacter sphaeroides W48, R. sphaeroides W42, and a mixture of R. sphaeroides W48 and W42). The results indicated that the supplementation ... P, Al-P, and Ca-P) and strain W48 in biofertilizers for Fe-P and Al-P. Furthermore, the supplementation of biofertilizers from R. sphaeroides W48 and W42 individually and their mixture raised plant ... yield rose over 12.1%. Both R. sphaeroides W48 and W42 are potent for use as crop ...
Tópico(s): Phytase and its Applications
2022 - Hindawi Publishing Corporation | Applied and Environmental Soil Science
Éric Manchon, David Laplaud, Sandra Vukusic, Pierre Labauge, Thibault Moreau, Gisela Kobelt, Jean‐Marie Grouin, Marie Lotz, David Pau, Lebrun Christine,
... and treatment satisfaction were described at W24 and W48. Adverse events were described until W72.Among the ... 67.9%]) were free of disease activity at W48 (RRMS: 62.2% [57.1%; 67.2%], SPMS: ... SPMS: 87.0%) were relapse-free up to W48, and the overall adjusted annualized relapse rate was ... confirmed disability progression, and no MRI activity) at W48. All PRO scores were stable between the first dose of ocrelizumab and W48 and better outcomes were seen for patients having ...
Tópico(s): Rheumatoid Arthritis Research and Therapies
2022 - Elsevier BV | Multiple Sclerosis and Related Disorders
... Export Citation NASA/ADS CO Spectroscopy of the W48 Molecular Cloud near 1.3 Millimeters Vallee, J. P. ; MacLeod, J. M. Abstract The W48 molecular cloud has been observed in the J = ... SPECTRA; NEBULAE: H II REGIONS; NEBULAE: INDIVIDUAL ALPHANUMERIC: W48 full text sources ADS | data products SIMBAD (3)
Tópico(s): Spectroscopy and Laser Applications
1990 - IOP Publishing | The Astrophysical Journal
Lana Saleh, Brian A. Kelch, Betsy A. Pathickal, Jeffrey Baldwin, Brenda A. Ley, J. Martin Bollinger,
... electron from a near-surface residue, tryptophan 48 (W48), to an adduct between O2 and diiron(II) cluster to generate a readily reducible cation radical (W48+•) and the formally Fe(IV)Fe(III) intermediate ... step is blocked in the R2 variant with W48 replaced by phenylalanine [Krebs, C., Chen, S., Baldwin, ... In this study, we show that substitution of W48 with alanine similarly disables the electron transfer (ET) ...
Tópico(s): CO2 Reduction Techniques and Catalysts
2004 - American Chemical Society | Biochemistry
Charlotte Charpentier, M. Choquet, Véronique Joly, P. Yéni, Benoît Visseaux, Marion Caséris, Françoise Brun‐Vézinet, Yazdan Yazdanpanah, Gilles Peytavin, Diane Descamps, R. Landman,
... at Week (W) 4, W12, W24, W36 and W48. Sixty patients initiated efavirenz, 81 darunavir/ritonavir and ... mL received darunavir/ritonavir (P = 0.022). At W48, 89%, 85% and 88% of the patients had ... respectively. Patients with a detectable VL signal at W48 had a higher baseline VL than those with ... of patients reaching VL <1 copy/mL at W48 was similar in the three regimens and was ...
Tópico(s): HIV/AIDS Research and Interventions
2014 - Oxford University Press | Journal of Antimicrobial Chemotherapy
Barbara Rossetti, Genny Meini, Cláudia Bianco, Silvia Lamonica, Annalisa Mondi, Simone Belmonti, Iuri Fanti, Nicoletta Ciccarelli, Simona Di Giambenedetto, Maurizio Zazzi, Andrea De Luca,
... 1DNA was detected in all patients while at W48 it was detectable in 82.4% of the ... was a significant decline of HIV-1DNA at W48 in the RASTA group (mean change from baseline - ... RASTA group vs 67% of controls and at W48 in 32.4% vs 42%, respectively. No differences ... found between HIV-1RNA levels at baseline and W48 within and between groups.Switching successful therapy to ...
Tópico(s): HIV/AIDS Research and Interventions
2017 - Elsevier BV | Journal of Clinical Virology
José Luis Revuelta-Herrero, Esther Chamorro‐de‐Vega, C Rodríguez-González, Roberto Alonso, Ana Herranz‐Alonso, María Sanjurjo‐Sáez,
... load [VL] <50 copies/mL) at week 48 (W48). Safety (incidence of adverse events leading to discontinuation ... of 14 years (interquartile range = 7-20). At W48, 91.4% of patients were virologically suppressed (95% ... not suppressed at baseline achieved undetectable VL at W48, and 2 patients discontinued DTG plus RPV (intolerance ... suppressed patients at baseline showed virological rebound through W48. There were no significant changes in lipid, liver, ...
Tópico(s): HIV Research and Treatment
2017 - SAGE Publishing | Annals of Pharmacotherapy
Charlotte Charpentier, Gilles Peytavin, François Raffi, Charles Burdet, Roland Landman, Minh Patrick Lê, Christine Katlama, Gilles Collin, Aı̈da Benalychérif, André Cabie, France Mentré, Yazdan Yazdanpanah, D. Descamps, Véronique Joly,
... at Day 0 (D0), Week 24 (W24) and W48 of dolutegravir + lamivudine, and HIV-DNA was measured at W-8 and W48. Semen samples were collected at D0 and W24 ... IQR = 2.1-2.9, n = 100) at W48 (P = 0.17). The proportion of patients with ... and 49% (n = 97) at D0, W24 and W48, respectively (P = 0.08). Total and unbound plasma ...
Tópico(s): HIV/AIDS Research and Interventions
2020 - Oxford University Press | Journal of Antimicrobial Chemotherapy
Antoine Bachelard, Valentina Isernia, Charlotte Charpentier, Aı̈da Benalychérif, Marion Mora, Cécile Donadille, Claudine Duvivier, Karine Lacombe, Mayssam El Mouhebb, Bruno Spire, Roland Landman, Diane Descamps, Gilles Peytavin, Lambert Assoumou, Jade Ghosn, Roland Landman, Jade Ghosn, Marion Mora, Lambert Assoumou, Gilles Peytavin, Diane Descamps, Charlotte Charpentier, Antoine Bachelard, Marie Préau, Sabrinel Sahali, Aı̈da Benalychérif, O. Godin, Cathia Soulié, Marc‐Antoine Valantin, David Zucman, Amina Fadli, Erwan Fourn, Éric Farfour, Sylvie Abel, André Cabie, Ornella Cabras, Lise Cuzin, Laurence Fagour, Sandrine Pierre-François, G. Pialoux, Anne Adda, Julie Chas, Martin Siguier, Christia Palacios, Nouara Agher, Amélie Chabrol, Thomas Gabas, Elisabete Gomes Pires, Fatima Touam, Claudine Duvivier, Pauline Cornavin, Faïza Ajana, Olivier Robineau, Louis Bernard, Guillaume Gras, Guillaume Brouillet, Olivier Bourgault, Isabelle Touitou, Alissa Naqvi, Pascale Goubin, Anne Ricci, Renaud Verdon, Christine Tramoni, Jacques Reynes, Séverine Lepuils, D. Neau, Carole Charles, Lionel Piroth, Christian Tran, Nadia Valin, Karine Lacombe, Zélie Julia, Sylvie LeGac, Antoine Bachelard, Jade Ghosn,
... According to FDA Snapshot analysis, at W24 and W48, 90/112, (80.4%; 95% CI: 71.8– ... at W24 and 14/112 (12.5%) at W48. No emergent resistance-associated mutation was detected in those with PDVF at W24 and W48. BIC/FTC/TAF was well tolerated through to W48, with a low incidence of grade 3–4 ...
Tópico(s): HIV Research and Treatment
2023 - Oxford University Press | Journal of Antimicrobial Chemotherapy
Constance Delaugerre, Philippe Flandre, Marie‐Laure Chaix, Jade Ghosn, François Raffi, P. Dellamonica, H. Jaeger, D. Shürmann, Isabelle Cohen-Codar, Philippe Ngo Van, Michael Norton, Anne‐Marie Taburet, Jean‐François Delfraissy, Christine Rouzioux,
... resistance-associated mutations (M46I at W40, L76V at W48, M46I and L76V at W48, L10F and V82A at W72, and L76V at ... among the three patients with protease changes by W48. No association between the baseline CD4 cell count ...
Tópico(s): HIV/AIDS Research and Interventions
2009 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Constance Delaugerre, Isabelle Charreau, Joséphine Braun, Marie‐Laure Nere, Nathalie De Castro, Patrick Yéni, Jade Ghosn, J Aboulker, Jean‐Michel Molina, François Simon,
... 30 patients enrolled in each arm, and at W48 in the raltegravir arm. Results: At W0 the ... circles were detected in three new patients. At W48 the total HIV DNA level in the raltegravir ... change was observed in the raltegravir arm at W48. Discussion: In most patients on effective HAART, including ...
Tópico(s): HIV/AIDS Research and Interventions
2010 - Lippincott Williams & Wilkins | AIDS
Sidonie Lambert-Niclot, Philippe Flandre, Marc‐Antoine Valantin, Gilles Peytavin, Claudine Duvivier, Stéphanie Haïm‐Boukobza, Michèle Algarté-Génin, Yazdan Yazdanpanah, Pierre‐Marie Girard, Christine Katlama, Vincent Cálvez, Anne‐Geneviève Marcelin,
... predictive of a virologic rebound at weeks 48 (W48) and 96 (W96).Receiving DRV/r monotherapy was associated with virologic rebound at W48 (P = .016) and W96 (P = .002), comparable to ... therapy. In the DRV/r monotherapy group, at W48, having a VL >50 copies/mL at day ...
Tópico(s): HIV Research and Treatment
2011 - Oxford University Press | The Journal of Infectious Diseases
Q. Nguyên Luong, F. Motte, M. Hennemann, T. Hill, K. L. J. Rygl, N. Schneider, S. Bontemps, A. Men’shchikov, Ph. André, N. Peretto, L. D. Anderson, D. Arzoumanian, L. Deharveng, P. Didelon, James Di Francesco, M. J. Griffin, J. M. Kirk, V. Könyves, P. G. Martin, A. Maury, V. Minier, S. Molinari, M. Pestalozzi, S. Pezzuto, Michael A. Reid, H. Roussel, M. Sauvage, F. Schüller, L. Testi, D. Ward‐Thompson, G. J. White, A. Zavagno,
... filament IRDC G035.39--00.33 in the W48 molecular complex is one of the darkest infrared ... textit{Herschel} Space Observatory as part of the W48 molecular cloud complex in the framework of the ...
Tópico(s): Galaxies: Formation, Evolution, Phenomena
2011 - EDP Sciences | Astronomy and Astrophysics
Silvia Nozza, Laura Galli, Sonja Chiappetta, Andrea Antinori, Chiara Tommasi, Massimo Di Pietro, Mauro Malnati, Davide De Battista, Giuseppe Tambussi, Adriano Lazzarin,
... 9–4.8) log 10 copies/mL. At W48, all patients in MVC group and 22/24 ( ... a higher expression of CCR5+CD4+ T cells [W48 change: +7.5% (−4.5/11) vs −5. ... and a higher increase of CD4+ effector memory [W48 change: +1.6% (0.7/4.8) vs ‐ ...
Tópico(s): HIV/AIDS Research and Interventions
2012 - International AIDS Society | Journal of the International AIDS Society
Mattias Mandorfer, Sebastian Steiner, Philipp Schwabl, B.A. Payer, Maximilian C. Aichelburg, Gerold Felician Lang, Katharina Grabmeier‐Pfistershammer, Michael Trauner, Markus Peck‐Radosavljevic, Thomas Reiberger,
... weeks of BOC/PEGIFN/RBV (total: 48 weeks [W48]).Fourteen patients (67%) had LI4W-W8UTND and were ... while 7 (33%) patients were allocated to the W48 arm. No breakthrough or relapse occurred in the ... SVR12TND) rate of 100% (12/12). In the W48 arm, the SVR12TND was 50% (3/6), with ...
Tópico(s): Hepatitis B Virus Studies
2014 - Oxford University Press | The Journal of Infectious Diseases
Stefano Rusconi, Paola Vitiello, Fulvio Adorni, Elisa Colella, Emanuele Focà, Amedeo Capetti, Paola Meraviglia, C Abeli, Stefano Bonora, Marco D’Annunzio, Antonio Di Biagio, Massimo Di Pietro, Luca Butini, Giancarlo Orofino, Manuela Colafigli, Gabriella d’Ettorre, Daniela Francisci, Giustino Parruti, Alessandro Soria, Anna Rita Buonomini, Chiara Tommasi, Silvia Mosti, Francesca Bai, Silvia Di Nardo Stuppino, Manuela Morosi, Marco Aurélio Echart Montano, Pamela Tau, Esther Merlini, Giulia Marchetti,
... W12 (p=.24 and p=.619) nor at W48 (p=.076 and p=.236). Patients continuing HAART ... a significant rise in circulating IL-7 by W48 (p=.01), and a trend in temporary reduction ... W12 (p=.06) that was not maintained at W48.Maraviroc intensification in INRs did not have a ...
Tópico(s): Mosquito-borne diseases and control
2013 - Public Library of Science | PLoS ONE
Bethany C. Larson, Jennifer R. Pomponio, Hannah S. Shafaat, Rachel H. Kim, Brian S. Leigh, Michael J. Tauber, Judy E. Kim,
... contains native tyrosine (Y108 and Y72) and tryptophan (W48) residues. A long-lived neutral tryptophan radical W48• is formed upon UV-photoexcitation of a zinc( ... an external electron acceptor. The quantum yield of W48• formation (Φ) depends upon the tyrosine residues in ...
Tópico(s): Porphyrin Metabolism and Disorders
2015 - American Chemical Society | The Journal of Physical Chemistry B
... maintained HIV-1 RNA < 50 c/mL at W48 (snapshot algorithm, 12% noninferiority margin); W96 was the ... 2, and RI+RTV, +0.9, similar to W48.One STB subject discontinued due to a renal AE after W48 (blood Cr increased).No case of proximal renal ...
Tópico(s): Mobile Health and mHealth Applications
2015 - Wiley | HIV Medicine
Marine Perrier, Charlotte Charpentier, Gilles Peytavin, Minh Patrick Lê, Louis Blondel, Benoît Visseaux, Véronique Joly, A. Pinto, Sophie Matheron, Yazdan Yazdanpanah, Diane Descamps, Roland Landman,
... 93% and 97% at W12, W24, W36 and W48, respectively. Five patients (3.3%) experienced a virological ... N155H mutations. At baseline, W12, W24, W36 and W48, 70%, 57%, 72%, 61% and 74% of the ... maintaining virological suppression with no residual viraemia until W48.
Tópico(s): Biochemical and Molecular Research
2017 - Oxford University Press | Journal of Antimicrobial Chemotherapy